Peripheral Blood CCR4+CCR6+ and CXCR3+CCR6+ CD4+ T-Cells ...
Peripheral Blood CCR4+CCR6+ and CXCR3+CCR6+ CD4+ T-Cells ...
Peripheral Blood CCR4+CCR6+ and CXCR3+CCR6+ CD4+ T-Cells ...
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Chemokine Receptors are Markers for <strong>CD4+</strong> T-<strong>Cells</strong> with<br />
Distinct Lineage Commitment <strong>and</strong> Antigenic Specificity<br />
CXCR3<br />
Th1<br />
T-bet<br />
IFNγ<br />
Th2<br />
GATA-3<br />
CCR4<br />
CCR4-CXCR3+CCR6-<br />
IL-4<br />
CMV-specific<br />
CCR4+CXCR3-CCR6-<br />
worm-specific<br />
CXCR3<br />
CCR6<br />
Th1Th17<br />
T-bet<br />
RORγ<br />
IFNγ, IL-17<br />
CCR4-<strong>CXCR3+CCR6+</strong><br />
M. tuberculosis-specific<br />
CCR6<br />
Th17<br />
RORγ<br />
IL-17<br />
CCR4<br />
CCR4+CXCR3-CCR6+<br />
C. albicans-specific<br />
Acosta-Rodriguez et al., Nat. Immunol., 2007<br />
• CXCR3 regulates cell<br />
migration into inflamed<br />
tissues including the gut<br />
• CCR4 regulates cell<br />
migration into skin tissues<br />
• CCR6 mediates cell<br />
homing into the GALT<br />
⇒ The permissiveness to<br />
HIV infection of these four<br />
memory <strong>CD4+</strong> T-cell<br />
subsets remains unknown
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