Anne Goriely - Illumina
Anne Goriely - Illumina
Anne Goriely - Illumina
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Proportion on -112G<br />
Unequal distribution of FGFR2 alleles<br />
provides evidence for selection<br />
1.00<br />
755 C>G Apert<br />
Mutation<br />
Selection<br />
0.75<br />
0.50<br />
0.25<br />
0.00<br />
0.1 1 10 100 1000<br />
755G mutant DNA (per million)<br />
Mutational events are infrequent<br />
but confer a selective advantage<br />
to the mutant spermatogonial<br />
stem cells<br />
<strong>Goriely</strong> et al Science (2003), PNAS (2005)
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