Anne Goriely - Illumina
Anne Goriely - Illumina
Anne Goriely - Illumina
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TD mutations in benign skin tumours<br />
Seborrheic Keratoses<br />
Wide spectrum of FGFR3 mutations<br />
80-100% of people over 50y<br />
Average 70 moles in people >75y<br />
S249C<br />
Y373C<br />
K650E<br />
R248C<br />
R248C<br />
R248C<br />
K650E<br />
R248C S249C<br />
G370C S371C<br />
Y373C K650E<br />
K650M<br />
S252W<br />
K650E<br />
K650T<br />
K650E<br />
S252W<br />
K650M<br />
K650M<br />
K650E<br />
K650M<br />
R248C<br />
Hafner et al, 2007, J. Inv. Derm 127<br />
These „selfish mutations‟ produce „moles‟ in<br />
the testis that can develop into tumours
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