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Fore “We shall not cease from exploration and the end of all our exploring will be to arrive where we started and know the place for the first time.” T. S. Elliot The basic scientific questions addressed in IMB’s second Annual Report are still the same as they were a century ago: How does an organism develop and how is its physiological homeostasis regulated? Science sets out with ever new expeditions to return with a bounty of new answers to the old questions. In this respect, IMB is a research vessel navigating between the fields of epigenetics, development, DNA repair and their unexplored interfaces. The year 2012 was an eventful one for IMB and included the appointment of René Ketting (Hubrecht Laboratory, The Netherlands) and Helle Ulrich (Clare Hall Laboratories, United Kingdom) as Research Directors. René brings research into RNA biology during the gonadogenesis of zebrafish and C. elegans to IMB, while Helle is an internationally renowned expert on the regulation of DNA repair who has just been awarded a prestigious ERC senior investigator grant. They complete the list of IMB’s senior scientists and bring exciting research themes to the institute. Both also hold a joint appointment with the Johannes Gutenberg University, Faculty of Biology. In January 2012 Jean-Yves Roignant, Natalia Soshnikova and Vijay Tiwari started their new research groups and quickly picked up speed, while in July Stefan Legewie acquired a € 1.14M grant from the BMBF to model biological networks.
I M B a n n u a l R e p o r t 2 0 1 2 word Table of Contents Foreword Research Groups Core Facilities Facts and Figures 3 A call for IMB proteomics Group Leaders was also successful and we hired Falk Butter, who will join us in 2013 after a successful postdoc with Matthias Mann. Falk uses mass spectrometry to identify and analyse DNA binding proteins. A symposium celebrating the scientific inauguration of IMB took place in March and was graced by a cast of highly renowned speakers who discussed topics spanning from DNA repair to reprogramming. Among the speakers was Sir John Gurdon, who went on to win the Nobel Prize in Medicine later in the year. The symposium drew a large audience and saw the IMB auditorium packed. IMB also plans to run an annual scientific conference. The first of these took place in October and was the first ever meeting on the topic of DNA demethylation; a topic which constitutes one of the most recent frontiers of epigenetics. The lively conference featured pioneers of the field, was of a high calibre and set the standards for future IMB conferences. Besides the conference, IMB also ran regular research seminars with invited speakers, many of whom were curious to visit the institute. IMB Group Leaders recruit their PhD students via our newly established International PhD Programme (IPP) that focuses on research regarding the Dynamics of Gene Regulation, Epigenetics and DNA Damage Response. This IPP, which is generously funded by the Boehringer Ingelheim Foundation, aims to attract top students to the Mainz campus. Group Leaders of the IPP are those of IMB as well as 14 members from the Johannes Gutenberg University, the University Medical Center, and the Max Planck Institute for Polymer Research. The IPP is therefore an important instrument for integration across the research campus. In fact, after only one and half years of existence, it is fair to say that IMB is already fully rooted on campus and through a variety of research initiatives and collaborations has become an important partner in the local biomedical research community. In spring and autumn calls were made for applications to the IPP and more than half of the 18 students recruited were non-German, highlighting the international aspect of the programme. To support the IPP, we organized an International Summer School (ISS), during which university students spent six weeks at IMB. While here, they attended training courses and lectures, and undertook a small research project within the laboratory of one of the IPP Group Leaders. All of these scientific events where smoothly organized by Ralf Dahm and his team. During a two day Group Leader retreat IMB faculty met to share research plans and discuss the institute‘s development. The IMB Core Facilities, supervised by Bernd Korn, were further consolidated with additional personnel and equipment acquisitions. The Core Facilities play an important role in enabling IMB scientists to get access to the latest equipment, supervised by technology experts. Notably, the large aquaria to house zebrafish and Xenopus frogs as model organisms were installed and the first inhabitants moved in. IMB Core Facilities are also used by colleagues from the University campus and as such they further contribute to the integration of the institute into the local research landscape. Another notable event was the completion of the second phase of IMB‘s construction, and the resulting movement of researchers into the south wing. There were many hiccups which had to be dealt with in order to achieve this, but they were kept in check by the tireless efforts of Bernd Korn from the technical side and Stephanie Oehl from the legal side. The additional space will be required as the number of IMB employees hits the “100 mark” and continues to grow, mostly with scientific personnel and students. We have great expectations for 2013. Helle Ulrich and Falk Butter will move in with their groups, a call for Group Leader recruitment has been advertised for further research expansion, and with the University Faculty of Biology we are planning the joint appointment of a Bioinformatics Professorship. In October, we will hold the second in our series of IMB conferences entitled Chromatin Dynamics & Stem Cells. To continue with our quick start, we again relied on the effective team of administrators, managers, Core Facility experts, technicians, and not least a large number of colleagues from Johannes Gutenberg University Mainz. We are very grateful to all of them for their support. We are also indebted to Walter Kröll and Jörg Michaelis for their great engagement during the recruitment of IMB’s Research Directors. We gratefully acknowledge our main sponsor, the Boehringer Ingelheim Foundation, and their commitment and genuine interest in IMB. It has again been a very good year for IMB and the institute has set sail for an exciting research voyage on the ocean of molecular life sciences. Christof Niehrs Founding Director
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