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Single-molecule manipulation experiments of biological molecules 3

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Temperature and Chemical Denaturant Dependent<br />

<strong>of</strong> Unfolding Free Energy Barrier <strong>of</strong> Titin I27<br />

• Trends are consistent with bulk chemical denaturant<br />

<strong>experiments</strong>. ΔH ‡ =29 kcal/mol, ΔS ‡ =0.06 kcal/mol-T.<br />

Botello, Harris, Sargent, Chen, Lin, and Kiang, J. Phys. Chem. B (2009) in press.<br />

Ching-Hwa Kiang

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