Curriculum Vitae Univ.-Prof. Dr. Kai-Uwe Froehlich - LIPOTOX

Curriculum Vitae
Univ.-Prof. Dr. Kai-Uwe Froehlich
Institute of Molecular Biosciences, University of Graz, Humboldtstrasse 50, A-8010 Graz; phone: +43-316-380
5686, fax: +43-316-380 9898, email: kai-uwe.froehlich@uni-graz.at
Personal data
Date of Birth November 19, 1956
Place of Birth Hannover, Germany
University education
1976-1982 Studies of Biochemistry (Diploma) at the University of Tuebingen, Germany
1981-1982 Diploma thesis “Enzymatic and genetic regulation of carbon catabolite
repression and gluconeogenesis in Saccharomyces cerevisiae”
1982-1984
Career history
Ph.D. thesis “Function of hexokinase PII in glucose regulation in the yeast
Saccharomyces cerevisiae”, Ph. D. in Biochemistry, University of Tuebingen,
funded by “Studienstiftung des deutschen Volkes”
1984-1989 Staff scientist at the Institute of Biochemistry, University of Tuebingen
1984-1984 Visiting scientist at the Institute of Biochemistry, University of Oxford (Dr. Alan
Kingsman and Prof. Sanders Williams, mentors)
1985-1985 Visiting scientist at the John-Innes-Institute in Norwich/Great Britain (Prof. David
Hopwood, mentor)
1985-1986 Postdoctoral fellow at the MIT in Cambridge/USA (Prof. David Botstein, mentor)
1989-1995 Scientific assistant at the Institute of Biochemistry, University of Tuebingen
1990-1996 President of the Alumni organisation of Biochemists of Tuebingen (MoBBEL
e.V.)
1994 Habilitation for Biochemistry and Physiological Chemistry, appointed
1995-1901
“Privatdozent”
University lecturer at the Institute of Biochemistry, University of Tuebingen
2000 appointed “außerplanmaeßiger Professor”
since 2001 University professor at the IMBM/IMB at the University of Graz, Austria
since 2004 Head of the Institute of Molecular Biology (IMB) at the University of Graz,
Austria
Research interests
Aging and apoptosis in unicellular eukaryotes. Basic components and evolution of programmed cell
death. Evolution and functions of the AAA protein family. Role of Cdc48p/VCP in lower and higher
eukaryotes.
Peer reviewed publications (present - 2005)
1. Carmona-Gutiérrez D, Reisenbichler A, Heimbucher P, Bauer MA, Braun RJ, Ruckenstuhl C,
Büttner S, Eisenberg T, Rockenfeller P, Fröhlich KU, Kroemer G, Madeo F. 2011. Ceramide triggers
metacaspase-independent mitochondrial cell death in yeast. Cell Cycle 10(22), Epub ahead of print.
2. Carmona-Gutiérrez D, Bauer MA, Ring J, Knauer H, Eisenberg T, Büttner S, Ruckenstuhl C,
Reisenbichler A, Magnes C, Rechberger GN, Birner-Gruenberger R, Jungwirth H, Fröhlich KU, Sinner
F, Kroemer G and Madeo F. 2011. The propeptide of yeast cathepsin D inhibits programmed necrosis.
Cell Death Dis 2:e161.
3. Büttner S, Ruli D, Vögtle FN, Galluzzi L, Moitzi B, Eisenberg T, Kepp O, Habernig L, Carmona-
Gutierrez D, Rockenfeller P, Laun P, Breitenbach M, Khoury C, Fröhlich KU, Rechberger G, Meisinger
C, Kroemer G and Madeo F. 2011. A yeast BH3-only protein mediates the mitochondrial pathway of
apoptosis. EMBO J 30(14):2779-2792.
4. Lang S, Gruber K, Mihajlovic S, Arnold R, Gruber CJ, Steinlechner S, Jehl MA, Rattei T, Fröhlich
KU and Zechner EL. 2010. Molecular recognition determinants for type IV secretion of diverse families
of conjugative relaxases. Mol Microbiol 78(6):1539-1555.
5. Laschober GT, Ruli D, Hofer E, Muck C, Carmona-Gutierrez D, Ring J, Hutter E, Ruckenstuhl C,
Micutkova L, Brunauer R, Jamnig A, Trimmel D, Herndler-Brandstetter D, Brunner S, Zenzmaier C,

Sampson N, Breitenbach M, Fröhlich KU, Grubeck-Loebenstein B, Berger P, Wieser M, Grillari-
Voglauer R, Thallinger GG, Grillari J, Trajanoski Z, Madeo F, Lepperdinger G and Jansen-Dürr P.
2010. Identification of evolutionarily conserved genetic regulators of cellular aging. Aging Cell
9(6):1084-1097.
6. Carmona-Gutierrez D, Fröhlich KU, Kroemer G and Madeo F. 2010. Metacaspases are caspases.
Doubt no more. Cell Death Differ 17(3):377-378.
7. Sollner S, Durchschlag M, Fröhlich KU and Macheroux P. 2009. The redox-sensing quinone
reductase Lot6p acts as an inducer of yeast apoptosis. FEMS Yeast Res 9(6):885-891.
8. Ruckenstuhl C, Buttner S, Carmona-Gutierrez D, Eisenberg T, Kroemer G, Sigrist SJ, Frohlich KU
and Madeo F. 2009. The warburg effect suppresses oxidative stress induced apoptosis in a yeast
model for cancer. PLoS One 4(2):e4592.
9. Eisenberg T, Knauer H, Schauer A, Buttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J,
Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E,
Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B,
Frohlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G and Madeo F. 2009. Induction of
autophagy by spermidine promotes longevity. Nat Cell Biol 11(11):1305-1314.
10. Madeo F, Durchschlag M, Kepp O, Panaretakis T, Zitvogel L, Frohlich KU and Kroemer G. 2009.
Phylogenetic conservation of the preapoptotic calreticulin exposure pathway from yeast to mammals.
Cell Cycle 8(4):639-642.
11. Schauer A, Knauer H, Ruckenstuhl C, Fussi H, Durchschlag M, Potocnik U and Fröhlich KU. 2009.
Vacuolar functions determine the mode of cell death. Biochim Biophys Acta 1793(3):540-545.
12. Ande SR, Fussi H, Knauer H, Murkovic M, Ghisla S, Fröhlich KU and Macheroux P. 2008.
Induction of apoptosis in yeast by L-amino acid oxidase from the Malayan pit viper Calloselasma
rhodostoma. Yeast 25(5):349-357.
13. Kern A, Hartner FS, Freigassner M, Spielhofer J, Rumpf C, Leitner L, Fröhlich KU and Glieder A.
2007. Pichia pastoris "just in time" alternative respiration. Microbiology 153(Pt 4):1250-1260.
14. Fröhlich KU, Fussi H and Ruckenstuhl C. 2007. Yeast apoptosis--from genes to pathways. Semin
Cancer Biol 17(2):112-121.
15. Madeo F and Frohlich KU. 2008. Apoptosis in yeast. Preface. Biochim Biophys Acta 1783:1271.
16. Lepperdinger G, Berger P, Breitenbach M, Frohlich KU, Grillari J, Grubeck-Loebenstein B, Madeo
F, Minois N, Zwerschke W and Jansen-Durr P. 2008. The use of genetically engineered model
systems for research on human aging. Front Biosci 13:7022-7031.
17. Panaretakis T, Joza N, Modjtahedi N, Tesniere A, Vitale I, Durchschlag M, Fimia GM, Kepp O,
Piacentini M, Froehlich KU, van Endert P, Zitvogel L, Madeo F and Kroemer G. 2008. The cotranslocation
of erp57 and calreticulin determines the immunogenicity of cell death. Cell Death Differ
15(9):1499-1509.
18. Buttner S, Eisenberg T, Carmona-Gutierrez D, Ruli D, Knauer H, Ruckenstuhl C, Sigrist C,
Wissing S, Kollroser M, Frohlich KU, Sigrist S and Madeo F. 2007. Endonuclease g regulates budding
yeast life and death. Mol Cell 25(2):233-246.
19. Hauptmann P, Riel C, Schughart L, Froehlich KU, Madeo F and Lehle L. 2005. Defects in Nglycosylation
induce apoptosis in yeast. Mol Microbiol 59(3):765-778.