Hepatitis D (Delta) Virus
Hepatitis D (Delta) Virus
Hepatitis D (Delta) Virus
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d antigen<br />
<strong>Hepatitis</strong> D (<strong>Delta</strong>) <strong>Virus</strong><br />
HBsAg<br />
RNA
<strong>Hepatitis</strong> D - Clinical Features<br />
• Coinfection<br />
–severe acute disease<br />
–low risk of chronic infection<br />
• Superinfection<br />
–usually develop chronic HDV infection<br />
–high risk of severe chronic liver disease
<strong>Hepatitis</strong> D <strong>Virus</strong><br />
Modes of Transmission<br />
• Percutanous exposures<br />
–injecting drug use<br />
• Permucosal exposures<br />
–sex contact
HBV - HDV Coinfection<br />
Typical Serologic Course<br />
Symptoms<br />
ALT Elevated<br />
Titer<br />
IgM anti-HDV<br />
anti-HBs<br />
HDV RNA<br />
HBsAg<br />
Total anti-HDV<br />
Time after Exposure
HBV - HDV Superinfection<br />
Typical Serologic Course<br />
Jaundice<br />
Symptoms<br />
ALT<br />
Total anti-HDV<br />
Titer<br />
HBsAg<br />
HDV RNA<br />
IgM anti-HDV<br />
Time after Exposure
Geographic Distribution of HDV Infection<br />
Taiwan<br />
Pacific Islands<br />
HDV Prevalence<br />
High<br />
Intermediate<br />
Low<br />
Very Low<br />
No Data
<strong>Hepatitis</strong> D - Prevention<br />
• HBV-HDV Coinfection<br />
Pre or postexposure prophylaxis to prevent HBV<br />
infection<br />
• HBV-HDV Superinfection<br />
Education to reduce risk behaviors among<br />
persons with chronic HBV infection
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