Mode of action of etoxazole - ResearchGate

R Nauen, G Smagghe
Table 1. Effect of etoxazole and triflumuron on the net amount of
KOH-resistant 14 C-GluNAc incorporated into the integument of
Spodoptera frugiperda. DataaregivenaspIC 50 (±standard error) and
the 95% fiducial limits after sigmoidal curve fitting of the
dose–response curves from Fig. 1. The goodness of fit is given as R 2
Compound pIC 50 (±SE) 95% fiducial limits R 2
Etoxazole 5.53 (±0.17) 5.15–5.90 0.90
Triflumuron 7.15 (±0.10) 6.93–7.36 0.98
is similar to that described for diflubenzuron on Chilo
suppressalis Walker (20 nM), thus indicating the validity
of the chosen assay format with S. frugiperda integuments.
Thus from our experimental results we conclude
that etoxazole is an acaricidal (and insecticidal) chitin
biosynthesis inhibitor with a mode of action similar
to that of benzoylphenylureas, i.e. inhibiting the
incorporation of the radiolabelled chitin precursor
[ 14 C]GluNAc into the integuments of pest invertebrates
affected by this compound.
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DOI: 10.1002/ps