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<strong>IRB</strong> BARCELONA 2011 ANNUAL REPORT<br />
Research Programmes<br />
Structural and Computational Biology<br />
Maria J. Macias: Protein NMR Spectroscopy<br />
Group Members<br />
Group Leader<br />
Maria J. Macias (ICREA)<br />
Postdoctoral Fellow<br />
James Gordon<br />
Highlights<br />
• SMAD binding proteins.<br />
• Inter- and intra-molecular interactions in E3 ubiquitin ligases.<br />
• Molecular and structural analysis of ribonucleoprotein complexes.<br />
PhD Students<br />
Eric Aragón<br />
Albert Escobedo<br />
Constanze Schelhorn<br />
Lab Technicians<br />
Tiago Lopes<br />
Lidia Ruiz<br />
Research Assistant<br />
Pau Martín<br />
Visiting Scientist<br />
Carlos Alberto Areche<br />
Publications<br />
• Aragón E, Goerner N, Zaromytidou AI, Xi Q, Escobedo A, Massagué J and Macias MJ.<br />
A Smad action turnover switch operated by WW domain readers of a phosphoserine code<br />
Genes Dev, 25, 1275-88 (2011)<br />
• Ramón R, Martín-Gago P, Verdaguer X, Macias MJ, Martin-Malpartida P, Fernández-Carneado J,<br />
Gomez-Caminals M, Ponsati B, López-Ruiz P, Cortés MA, Colás B and Riera A.<br />
SSTR1- and SSTR3-Selective Somatostatin Analogues<br />
Chembiochem, 12, 625-32 (2011)<br />
PhD Theses<br />
• Interactions of Smads and WW domains of proteins involved in TGF-signaling, Nina Goerner, Freie<br />
Universität Berlin. Thesis director: Maria J. Macias, honors: (Magna cum laude)
Research projects<br />
• Estudio estructural de los cambios conformacionales en las ubiquitin ligasas ITCH y RSP5 por RMN .<br />
Proyectos de investigación fundamental (BFU2008-02795). Spanish Ministry of Science and Innovation<br />
(MICINN). 2009-2011. Principal investigator: Maria J. Macias<br />
• Integrated approach to post-transcriptional regulation of gene expression and its role in human disease,<br />
RNAREG. Consolider-Ingenio-2010 (CSD2009-00080). Spanish Ministry of Science and Innovation<br />
(MICINN). 2010-2014. Principal investigator: Maria J. Macias<br />
• Unitat de recerca en síntesi asimètrica. Grups de Recerca reconeguts per la Generalitat de Catalunya<br />
2009-2013 (2009 SGR 901). Agency for Administration of University and Research Grants (AGAUR).<br />
2009-2013. Principal investigator: Antoni Riera<br />
• BCN PEPTIDES S.A. 2009-2014 Maria J. Macias<br />
Collaborations<br />
• NMR studies of somatostatin and derivatives, Antoni Riera, <strong>IRB</strong> <strong>Barcelona</strong> (<strong>Barcelona</strong>, Spain)<br />
• Protein and Peptide ligations, Miriam Royo, <strong>Barcelona</strong> Science Park (<strong>Barcelona</strong>, Spain)<br />
• Protein-protein and protein-RNA complexes, Juan Valcárcel, Center for Genomic Regulation (<strong>Barcelona</strong>,<br />
Spain); Raul Mendez, <strong>IRB</strong> <strong>Barcelona</strong> (<strong>Barcelona</strong>, Spain)<br />
• SMAD proteins, Joan Massagué, Memorial-Sloan Kettering Cancer Center (New York, United States)<br />
INSTITUTE<br />
FOR RESEARCH<br />
IN BIOMEDICINE<br />
© Institute for Research in Biomedicine (<strong>IRB</strong> <strong>Barcelona</strong>)<br />
Parc Científic de <strong>Barcelona</strong>. C/ Baldiri Reixac 10. 08028 <strong>Barcelona</strong> - Spain<br />
Tel: +34 93 402 02 50 | Fax: +34 93 403 71 14<br />
info@irbbarcelona.org
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