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aluminum and mercury in vaccines through 2007 Ayoub ... - SafeMinds

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Number of adm<strong>in</strong>istered vacc<strong>in</strong>es conta<strong>in</strong><strong>in</strong>g<br />

<strong>alum<strong>in</strong>um</strong> or ethyl<strong>mercury</strong> by 18 months age<br />

20<br />

<strong>alum<strong>in</strong>um</strong>-conta<strong>in</strong><strong>in</strong>g shots<br />

15<br />

10<br />

10<br />

10<br />

11<br />

11<br />

15 15 15<br />

17<br />

5 4 4 4 4<br />

5<br />

<strong>mercury</strong>-conta<strong>in</strong><strong>in</strong>g shots<br />

5<br />

3 3<br />

4 4 4 4<br />

0 0<br />

0<br />

1970 1974 1977 1982 1986 1994 2000 2001 2003 2004 <strong>2007</strong><br />

Alum<strong>in</strong>um-conta<strong>in</strong><strong>in</strong>g shots<br />

Mercury-conta<strong>in</strong><strong>in</strong>g shots


Cumulative <strong>alum<strong>in</strong>um</strong>(mg) by age 18 months<br />

6,000<br />

5,400<br />

4,900<br />

4,500<br />

3,925<br />

4,400<br />

3,000<br />

2,500<br />

2,725<br />

1,500<br />

0<br />

1970-85 1986-93 1994 1995-00 2001-06 <strong>2007</strong>


Maximum cumulative <strong>alum<strong>in</strong>um</strong>(mg) by age 18 months<br />

5,400<br />

5,400<br />

5,050<br />

4,900<br />

4,900<br />

4,900<br />

4,900<br />

4,900<br />

4,900<br />

4,700<br />

4,350<br />

4,400<br />

4,000<br />

2000 2001 2002 2003 2004 2005 2006 <strong>2007</strong><br />

DTP(4)<br />

HepB(3)<br />

HiB(4)<br />

+PCV(4)<br />

+HepA(2)


History of Exposure to Vacc<strong>in</strong>e Ethyl<strong>mercury</strong><br />

Cumulative <strong>mercury</strong>(mcg) by age 5 yr<br />

250<br />

200<br />

212.5<br />

237.5<br />

maximum=137.5mcg<br />

or 58% of the 1999<br />

peak<br />

150<br />

+ prenatal<br />

100<br />

100.0<br />

112.5<br />

112.5<br />

50<br />

0<br />

???<br />

+ prenatal<br />

50.0<br />

1970-85 1986-93 1994 1995-99 2000-03 2004-05 2006-07


Alum<strong>in</strong>um exposure (micrograms) first 2 years via CDC schedule: <strong>2007</strong><br />

Al-conta<strong>in</strong><strong>in</strong>g<br />

vacc<strong>in</strong>e<br />

HepB<br />

Energix<br />

0<br />

3.30 kg<br />

2mo<br />

4.86 kg<br />

4mo<br />

6.54 kg<br />

6mo<br />

7.80 kg<br />

12 mo<br />

10.1 kg<br />

15 mo<br />

10.9 kg<br />

250 250 - 250 250 -<br />

18 mo<br />

11.5 kg<br />

DTaP<br />

Infanrix<br />

HiB<br />

Pedvax<br />

PCV<br />

Prevnar<br />

HepA<br />

Havrix<br />

Max dose<br />

(μg)<br />

Max weight<br />

adjusted dose<br />

μg/kg/day<br />

- 625 625 625 625 625<br />

- 225 225 225 225 225<br />

- 125 125 125 125 125<br />

- - - - 250 250<br />

250 1225 975 1225 850 975 875<br />

75.8 252 149 157 84.1 89.4 76.1<br />

5.4 mg<br />

doses given <strong>in</strong> the specified range of ages

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