Sulfamic acid - Santa Cruz Biotechnology

Sulfamic acid 

Material Safety Data Sheet 

sc-203409 

Hazard Alert Code Key: EXTREME HIGH MODERATE LOW 

PRODUCT NAME 


Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION 

STATEMENT OF HAZARDOUS NATURE 

CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. 

NFPA 

0 

FLAMMABILITY 

HEALTH HAZARD INSTABILITY 

2 0 

SUPPLIER 

Company: Santa Cruz Biotechnology, Inc. 

Address: 

2145 Delaware Ave 

Santa Cruz, CA 95060 

Telephone: 800.457.3801 or 831.457.3800 

Emergency Tel: CHEMWATCH: From within the US and Canada: 

877-715-9305 

Emergency Tel: From outside the US and Canada: +800 2436 2255 

(1-800-CHEMCALL) or call +613 9573 3112 

PRODUCT USE 

Used for cleaning metals and ceramics; standard in alkalimetry; nitrite removal in dyeing; stabilisation of chlorine and hypochlorite for 

swimming pools; sulfonating agent; organic synthesis; pH control; hard water scale removal; electroplating. Laboratory reagent. 

SYNONYMS 

H3-N-O3-S, H3-N-O3-S, NH2-SO3-H, NH2-SO2-OH, "Hach Sulfamic Acid Reagent", "amidosulphonic acid", "amidosulphuric acid", 

"aminosulphonic acid", "aminosulphuric acid", "sulphamidic acid", "sulphamic acid, solid", "amidosulfonic acid", "amidosulfuric acid", 

"aminosulfonic acid", "aminosulfuric acid", "sulfamidic acid", "sulfamidic acid, solid", RIA-40, TECH00005955, AR00000531, UL00000532, 

SUACID20, 03102003, Spectrum, S1698, S1700, S1701, "Ikon sulphamic acid", "Jasol Sulphamic Acid" 

CANADIAN WHMIS SYMBOLS 

Section 2 - HAZARDS IDENTIFICATION 

EMERGENCY OVERVIEW 

RISK 

Irritating to eyes and skin. 

Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. 

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POTENTIAL HEALTH EFFECTS 

ACUTE HEALTH EFFECTS 

SWALLOWED 

! The material can produce chemical burns within the oral cavity and gastrointestinal tract following ingestion. 

! The material has NOT been classified as "harmful by ingestion". This is because of the lack of corroborating animal or human evidence. 

The material may still be damaging to the health of the individual, following ingestion, especially where pre-existing organ (e.g. liver, kidney) 

damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than 

those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting 

however, unintentional ingestion is not thought to be cause for concern. 

! Ingestion of acidic corrosives may produce burns around and in the mouth. the throat and esophagus. Immediate pain and difficulties in 

swallowing and speaking may also be evident. Swelling of the epiglottis may make it difficult to breathe which may result in suffocation. More 

severe exposure may result in vomiting blood and thick mucus, shock, abnormally low blood pressure, fluctuating pulse, shallow respiration 

and clammy skin, inflammation of stomach wall, and rupture of esophageal tissue. Untreated shock may eventually result in kidney failure. 

Severe cases may result in perforation of the stomach and abdominal cavity with consequent infection, rigidity and fever. There may be 

severe narrowing of the esophageal or pyloric sphincters; this may occur immediately or after a delay of weeks to years. There may be coma 

and convulsions, followed by death due to infection of the abdominal cavity, kidneys or lungs. 

! Ingestion of sulfamic acid may cause vomiting, diarrhoea and a drop in blood pressure. Asphyxia may occur from oedema of the glottis. 

After initial recovery, onset of fever indicates mediastinitis or peritonitis from perforation of the esophagus or stomach. Ingestion of greater 

than 10% solutions will cause lesions of the stomach. 

EYE 

! This material can cause eye irritation and damage in some persons. 

! The material can produce chemical burns to the eye following direct contact. Vapors or mists may be extremely irritating. 

! Direct eye contact with acid corrosives may produce pain, tears, sensitivity to light and burns. Mild burns of the epithelia generally recover 

rapidly and completely. Severe burns produce long-lasting and possibly irreversible damage. The appearance of the burn may not be 

apparent for several weeks after the initial contact. The cornea may ultimately become deeply opaque resulting in blindness. 

! If applied to the eyes, this material causes severe eye damage. 

SKIN 

! This material can cause inflammation of the skin oncontact in some persons. 

! The material can produce chemical burns following direct contactwith the skin. 

! Skin contact is not thought to have harmful health effects, however the material may still produce health damage following entry through 

wounds, lesions or abrasions. 

! Concentrated solutions may cause chemical burns. The effects of sulfamic acid on the skin appear to be limited to the effects of low pH. 

Concentrations of greater than 20% of sulfamic acid may injure the skin. 

Repeated application of a 4% solution of sulfamic acid several times a day for 5 days on the skin produced mild irritation. 

! Open cuts, abraded or irritated skin should not be exposed to this material. 

! Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine 

the skin prior to the use of the material and ensure that any external damage is suitably protected. 

! Skin contact with acidic corrosives may result in pain and burns; these may be deep with distinct edges and may heal slowly with the 

formation of scar tissue. 

! Solution of material in moisture on the skin, or perspiration, may markedly increase skin corrosion and accelerate tissue destruction. 

INHALED 

! Inhalation of sulfamic acid may cause bloody spit, difficulty breathing, low blood pressure, headache, dizziness, bluish skin colour and lung 

congestion. 

! Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further 

disability if excessive concentrations of particulate are inhaled. 

! Corrosive acids can cause irritation of the respiratory tract, with coughing, choking and mucous membrane damage. There may be 

dizziness, headache, nausea and weakness. Swelling of the lungs can occur, either immediately or after a delay; symptoms of this include 

chest tightness, shortness of breath, frothy phlegm and cyanosis. Lack of oxygen can cause death hours after onset. 

! The material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage. 

CHRONIC HEALTH EFFECTS 

! Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or 

biochemical systems. 

Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 

micron penetrating and remaining in the lung. Prime symptom is breathlessness; lung shadows show on X-ray. 

Repeated or prolonged exposure to acids may result in the erosion of teeth, swelling and or ulceration of mouth lining. Irritation of airways to 

lung, with cough, and inflammation of lung tissue often occurs. Chronic exposure may inflame the skin or conjunctiva. 

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Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS 

HAZARD RATINGS 

Flammability: 0 

Toxicity: 0 

Min 

Max 

Body Contact: 3 

Reactivity: 0 

Chronic: 2 

Min/Nil=0 

Low=1 

Moderate=2 

High=3 

Extreme=4 

NAME CAS RN % 

sulfamic acid 5329-14-6 >98 

Section 4 - FIRST AID MEASURES 

SWALLOWED 

! 

For advice, contact a Poisons Information Center or a doctor at once. 

Urgent hospital treatment is likely to be needed. 

If swallowed do NOT induce vomiting. 

If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain open airway and prevent 

aspiration. 

Observe the patient carefully. 

Never give liquid to a person showing signs of being sleepy or with reduced awareness; i.e. becoming unconscious. 

Give water to rinse out mouth, then provide liquid slowly and as much as casualty can comfortably drink. 

Transport to hospital or doctor without delay. 

EYE 

! If this product comes in contact with the eyes: 

Immediately hold eyelids apart and flush the eye continuously with running water. 

Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and moving the eyelids by occasionally lifting the upper 

and lower lids. 

Continue flushing until advised to stop by the Poisons Information Center or a doctor, or for at least 15 minutes. 

Transport to hospital or doctor without delay. 

Removal of contact lenses after an eye injury should only be undertaken by skilled personnel. 

SKIN 

! If skin or hair contact occurs: 

Immediately flush body and clothes with large amounts of water, using safety shower if available. 

Quickly remove all contaminated clothing, including footwear. 

Wash skin and hair with running water. Continue flushing with water until advised to stop by the Poisons Information Center. 

Transport to hospital, or doctor. 

INHALED 

! 

If fumes or combustion products are inhaled remove from contaminated area. 

Lay patient down. Keep warm and rested. 

Prostheses such as false teeth, which may block airway, should be removed, where possible, prior to initiating first aid procedures. 

Apply artificial respiration if not breathing, preferably with a demand valve resuscitator, bag-valve mask device, or pocket mask as trained. 

Perform CPR if necessary. 

Transport to hospital, or doctor. 

Inhalation of vapors or aerosols (mists, fumes) may cause lung edema. Corrosive substances may cause lung damage (e.g. lung edema, 

fluid in the lungs). As this reaction may be delayed up to 24 hours after exposure, affected individuals need complete rest (preferably in 

semi-recumbent posture) and must be kept under medical observation even if no symptoms are (yet) manifested. Before any such 

manifestation, the administration of a spray containing a dexamethasone derivative or beclomethasone derivative may be considered. This 

must definitely be left to a doctor or person authorized by him/her. (ICSC13719). 

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NOTES TO PHYSICIAN 

! Treat symptomatically. 

For acute or short term repeated exposures to strong acids: 

Airway problems may arise from laryngeal edema and inhalation exposure. Treat with 100% oxygen initially. 

Respiratory distress may require cricothyroidotomy if endotracheal intubation is contraindicated by excessive swelling 

Intravenous lines should be established immediately in all cases where there is evidence of circulatory compromise. 

Strong acids produce a coagulation necrosis characterized by formation of a coagulum (eschar) as a result of the dessicating action of 

the acid on proteins in specific tissues. 

INGESTION: 

Immediate dilution (milk or water) within 30 minutes post ingestion is recommended. 

DO NOT attempt to neutralize the acid since exothermic reaction may extend the corrosive injury. 

Be careful to avoid further vomit since re-exposure of the mucosa to the acid is harmful. Limit fluids to one or two glasses in an adult. 

Charcoal has no place in acid management. 

Some authors suggest the use of lavage within 1 hour of ingestion. 

SKIN: 

Skin lesions require copious saline irrigation. Treat chemical burns as thermal burns with non-adherent gauze and wrapping. 

Deep second-degree burns may benefit from topical silver sulfadiazine. 

EYE: 

Eye injuries require retraction of the eyelids to ensure thorough irrigation of the conjuctival cul-de-sacs. Irrigation should last at least 

20-30 minutes. DO NOT use neutralizing agents or any other additives. Several liters of saline are required. 

Cycloplegic drops, (1% cyclopentolate for short-term use or 5% homatropine for longer term use) antibiotic drops, vasoconstrictive agents 

or artificial tears may be indicated dependent on the severity of the injury. 

Steroid eye drops should only be administered with the approval of a consulting ophthalmologist). 

[Ellenhorn and Barceloux: Medical Toxicology]. 

Vapour Pressure (mmHG): 

Upper Explosive Limit (%): 

Specific Gravity (water=1): 2.15 

Lower Explosive Limit (%): 

Section 5 - FIRE FIGHTING MEASURES 

Not applicable 



EXTINGUISHING MEDIA 

! 

Water spray or fog. 

Foam. 

Dry chemical powder. 

BCF (where regulations permit). 

Carbon dioxide. 

FIRE FIGHTING 

! 

Alert Emergency Responders and tell them location and nature of hazard. 

Wear breathing apparatus plus protective gloves. 

Prevent, by any means available, spillage from entering drains or water course. 

Use fire fighting procedures suitable for surrounding area. 

DO NOT approach containers suspected to be hot. 

Cool fire exposed containers with water spray from a protected location. 

If safe to do so, remove containers from path of fire. 

Equipment should be thoroughly decontaminated after use. 

GENERAL FIRE HAZARDS/HAZARDOUS COMBUSTIBLE PRODUCTS 

! 

Non combustible. 

Not considered to be a significant fire risk. 

Acids may react with metals to produce hydrogen, a highly flammable and explosive gas. 

Heating may cause expansion or decomposition leading to violent rupture of rigid containers. 

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May emit corrosive, poisonous fumes. May emit acrid smoke. 

Decomposition may produce toxic fumes of: nitrogen oxides (NOx), sulfur oxides (SOx), hydrogen chloride. 

FIRE INCOMPATIBILITY 

! None known. 

PERSONAL PROTECTION 

Glasses: 

Chemical goggles. 

Full face- shield. 

Gloves: 

Respirator: 

Particulate 

Section 6 - ACCIDENTAL RELEASE MEASURES 

MINOR SPILLS 

! 

Drains for storage or use areas should have retention basins for pH adjustments and dilution of spills before discharge or disposal of 

material. 

Check regularly for spills and leaks. 

Clean up all spills immediately. 

Avoid contact with skin and eyes. 

Wear protective clothing, gloves, safety glasses and dust respirator. 

Use dry clean up procedures and avoid generating dust. 

Sweep up or vacuum up (consider explosion-proof machines designed to be grounded during storage and use). 

Place in clean drum then flush area with water. 

MAJOR SPILLS 

! 

Clear area of personnel and move upwind. 

Alert Emergency Responders and tell them location and nature of hazard. 

Wear breathing apparatus plus protective gloves. 

Prevent, by any means available, spillage from entering drains or water course. 

Stop leak if safe to do so. 

Contain spill with sand, earth or vermiculite. 

Collect recoverable product into labeled containers for recycling. 

Neutralize/decontaminate residue. 

Collect solid residues and seal in labeled drums for disposal. 

Wash area and prevent runoff into drains. 

After clean up operations, decontaminate and launder all protective clothing and equipment before storing and re-using. 

If contamination of drains or waterways occurs, advise emergency services. 

PROTECTIVE ACTIONS FOR SPILL 

From IERG (Canada/Australia) 

Isolation Distance 

25 meters 

Downwind Protection Distance 250 meters 

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FOOTNOTES 

1 PROTECTIVE ACTION ZONE is defined as the area in which people are at risk of harmful exposure. This zone assumes that random changes in wind direction confines the 

vapour plume to an area within 30 degrees on either side of the predominant wind direction, resulting in a crosswind protective action distance equal to the downwind protective 

action distance. 

2 PROTECTIVE ACTIONS should be initiated to the extent possible, beginning with those closest to the spill and working away from the site in the downwind direction. Within 

the protective action zone a level of vapour concentration may exist resulting in nearly all unprotected persons becoming incapacitated and unable to take protective action 

and/or incurring serious or irreversible health effects. 

3 INITIAL ISOLATION ZONE is determined as an area, including upwind of the incident, within which a high probability of localised wind reversal may expose nearly all persons 

without appropriate protection to life-threatening concentrations of the material. 

4 SMALL SPILLS involve a leaking package of 200 litres (55 US gallons) or less, such as a drum (jerrican or box with inner containers). Larger packages leaking less than 200 

litres and compressed gas leaking from a small cylinder are also considered "small spills". LARGE SPILLS involve many small leaking packages or a leaking package of greater 

than 200 litres, such as a cargo tank, portable tank or a "one-tonne" compressed gas cylinder. 

5 Guide 154 is taken from the US DOT emergency response guide book. 

6 IERG information is derived from CANUTEC - Transport Canada. 

ACUTE EXPOSURE GUIDELINE LEVELS (AEGL) (in ppm) 

AEGL 1: The airborne concentration of a substance above which it is predicted 

that the general population, including susceptible individuals, could 

experience notable discomfort, irritation, or certain asymptomatic nonsensory 

effects. However, the effects are not disabling and are transient and 

reversible upon cessation of exposure. 



experience irreversible or other serious, long-lasting adverse health effects 

or an impaired ability to escape. 



experience life-threatening health effects or death. 

Section 7 - HANDLING AND STORAGE 

PROCEDURE FOR HANDLING 

! 

Avoid all personal contact, including inhalation. 

Wear protective clothing when risk of exposure occurs. 

Use in a well-ventilated area. 

Avoid contact with moisture. 

Avoid contact with incompatible materials. 

When handling, DO NOT eat, drink or smoke. 

Keep containers securely sealed when not in use. 

Avoid physical damage to containers. 

Always wash hands with soap and water after handling. 

Work clothes should be laundered separately. Launder contaminated clothing before re-use. 

Use good occupational work practice. 

Observe manufacturer's storing and handling recommendations. 

Atmosphere should be regularly checked against established exposure standards to ensure safe working conditions are maintained. 

RECOMMENDED STORAGE METHODS 

! DO NOT use aluminum or galvanized containers. 

Check regularly for spills and leaks. 

Glass container. 

Lined metal can, Lined metal pail/drum 

Plastic pail 

Polyliner drum 

Packing as recommended by manufacturer. 

Check all containers are clearly labeled and free from leaks. 

For low viscosity materials 

Drums and jerricans must be of the non-removable head type. 

Where a can is to be used as an inner package, the can must have a screwed enclosure. 

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For materials with a viscosity of at least 2680 cSt. (23 deg. C) and solids (between 15 C deg. and 40 deg C.): 

Removable head packaging; 

Cans with friction closures and 

low pressure tubes and cartridges may be used. 

- Where combination packages are used, and the inner packages are of glass, porcelain or stoneware, there must be sufficient inert 

cushioning material in contact with inner and outer packages unless the outer packaging is a close fitting molded plastic box and the 

substances are not incompatible with the plastic. 

STORAGE REQUIREMENTS 

! 

Store in original containers. 

Keep containers securely sealed. 

Store in a cool, dry, well-ventilated area. 

Store away from incompatible materials and foodstuff containers. 

Protect containers against physical damage and check regularly for leaks. 

Observe manufacturer's storing and handling recommendations. 

SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS 

+ X + X X + 

X: Must not be stored together 

O: May be stored together with specific preventions 

+: May be stored together 

EXPOSURE CONTROLS 

Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION 

The following materials had no OELs on our records 

• sulfamic acid: CAS:5329-14-6 

MATERIAL DATA 

SULFAMIC ACID: 

! Sensory irritants are chemicals that produce temporary and undesirable side-effects on the eyes, nose or throat. Historically occupational 

exposure standards for these irritants have been based on observation of workers' responses to various airborne concentrations. Present 

day expectations require that nearly every individual should be protected against even minor sensory irritation and exposure standards are 

established using uncertainty factors or safety factors of 5 to 10 or more. On occasion animal no-observable-effect-levels (NOEL) are used to 

determine these limits where human results are unavailable. An additional approach, typically used by the TLV committee (USA) in 

determining respiratory standards for this group of chemicals, has been to assign ceiling values (TLV C) to rapidly acting irritants and to 

assign short-term exposure limits (TLV STELs) when the weight of evidence from irritation, bioaccumulation and other endpoints combine to 

warrant such a limit. In contrast the MAK Commission (Germany) uses a five-category system based on intensive odour, local irritation, and 

elimination half-life. However this system is being replaced to be consistent with the European Union (EU) Scientific Committee for 

Occupational Exposure Limits (SCOEL); this is more closely allied to that of the USA. 

OSHA (USA) concluded that exposure to sensory irritants can: 

cause inflammation 

cause increased susceptibility to other irritants and infectious agents 

lead to permanent injury or dysfunction 

permit greater absorption of hazardous substances and 

acclimate the worker to the irritant warning properties of these substances thus increasing the risk of overexposure. 

It is the goal of the ACGIH (and other Agencies) to recommend TLVs (or their equivalent) for all substances for which there is evidence of 

health effects at airborne concentrations encountered in the workplace. 

At this time no TLV has been established, even though this material may produce adverse health effects (as evidenced in animal experiments 

or clinical experience). Airborne concentrations must be maintained as low as is practically possible and occupational exposure must be kept 

to a minimum. 

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NOTE: The ACGIH occupational exposure standard for Particles Not Otherwise Specified (P.N.O.S) does NOT apply. 

PERSONAL PROTECTION 

Consult your EHS staff for recommendations 

EYE 

! 

Chemical goggles. 

Full face shield. 

Contact lenses pose a special hazard; soft lenses may absorb irritants and all lenses concentrate them. 

HANDS/FEET 

! Wear chemical protective gloves, eg. PVC. 

Wear safety footwear or safety gumboots, eg. Rubber. 

Suitability and durability of glove type is dependent on usage. Important factors in the selection of gloves include: such as: 

frequency and duration of contact, 

chemical resistance of glove material, 

glove thickness and 

dexterity 

Select gloves tested to a relevant standard (e.g. Europe EN 374, US F739). 

When prolonged or frequently repeated contact may occur, a glove with a protection class of 5 or higher (breakthrough time greater than 

240 minutes according to EN 374) is recommended. 

When only brief contact is expected, a glove with a protection class of 3 or higher (breakthrough time greater than 60 minutes according 

to EN 374) is recommended. 

Contaminated gloves should be replaced. 

Gloves must only be worn on clean hands. After using gloves, hands should be washed and dried thoroughly. Application of a non-perfumed 

moisturiser is recommended. 

OTHER 

! 

Overalls. 

PVC Apron. 

PVC protective suit may be required if exposure severe. 

Eyewash unit. 

Ensure there is ready access to a safety shower. 

! 

Respirators may be necessary when engineering and administrative controls do not adequately prevent exposures. 

The decision to use respiratory protection should be based on professional judgment that takes into account toxicity information, 

exposure measurement data, and frequency and likelihood of the worker's exposure - ensure users are not subject to high thermal loads 

which may result in heat stress or distress due to personal protective equipment (powered, positive flow, full face apparatus may be an 

option). 

Published occupational exposure limits, where they exist, will assist in determining the adequacy of the selected respiratory . These may 

be government mandated or vendor recommended. 

Certified respirators will be useful for protecting workers from inhalation of particulates when properly selected and fit tested as part of a 

complete respiratory protection program. 

Use approved positive flow mask if significant quantities of dust becomes airborne. 

Try to avoid creating dust conditions. 

RESPIRATOR 

! 

Protection Factor Half-Face Respirator Full-Face Respirator Powered Air Respirator 

10 x PEL P1 - PAPR-P1 

Air-line* - - 

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50 x PEL Air-line** P2 PAPR-P2 

100 x PEL - P3 - 

Air-line* - 

100+ x PEL - Air-line** PAPR-P3 

* - Negative pressure demand ** - Continuous flow 

Explanation of Respirator Codes: 

Class 1 low to medium absorption capacity filters. 

Class 2 medium absorption capacity filters. 

Class 3 high absorption capacity filters. 

PAPR Powered Air Purifying Respirator (positive pressure) cartridge. 

Type A for use against certain organic gases and vapors. 

Type AX for use against low boiling point organic compounds (less than 65ºC). 

Type B for use against certain inorganic gases and other acid gases and vapors. 

Type E for use against sulfur dioxide and other acid gases and vapors. 

Type K for use against ammonia and organic ammonia derivatives 

Class P1 intended for use against mechanically generated particulates of sizes most commonly encountered in industry, e.g. asbestos, silica. 

Class P2 intended for use against both mechanically and thermally generated particulates, e.g. metal fume. 

Class P3 intended for use against all particulates containing highly toxic materials, e.g. beryllium. 

The local concentration of material, quantity and conditions of use determine the type of personal protective equipment required. 

Use appropriate NIOSH-certified respirator based on informed professional judgement. In conditions where no reasonable estimate of 

exposure can be made, assume the exposure is in a concentration IDLH and use NIOSH-certified full face pressure demand SCBA with a 

minimum service life of 30 minutes, or a combination full facepiece pressure demand SAR with auxiliary self-contained air supply. Respirators 

provided only for escape from IDLH atmospheres shall be NIOSH-certified for escape from the atmosphere in which they will be used. 

ENGINEERING CONTROLS 

! 

Local exhaust ventilation is required where solids are handled as powders or crystals; even when particulates are relatively large, a 

certain proportion will be powdered by mutual friction. 

If in spite of local exhaust an adverse concentration of the substance in air could occur, respiratory protection should be considered. 

Such protection might consist of: 

(a): particle dust respirators, if necessary, combined with an absorption cartridge; 

(b): filter respirators with absorption cartridge or canister of the right type; 

(c): fresh-air hoods or masks 

Air contaminants generated in the workplace possess varying "escape" velocities which, in turn, determine the "capture velocities" of fresh 

circulating air required to effectively remove the contaminant. 

Type of Contaminant: 

direct spray, spray painting in shallow booths, drum filling, conveyer 

loading, crusher dusts, gas discharge (active generation into zone of 

rapid air motion) 

grinding, abrasive blasting, tumbling, high speed wheel generated 

dusts (released at high initial velocity into zone of very high rapid air 

motion). 

Within each range the appropriate value depends on: 

Lower end of the range 

Air Speed: 

1-2.5 m/s (200-500 f/min.) 

2.5-10 m/s (500-2000 f/min.) 

Upper end of the range 

1: Room air currents minimal or favorable to capture 1: Disturbing room air currents 

2: Contaminants of low toxicity or of nuisance value only. 2: Contaminants of high toxicity 

3: Intermittent, low production. 3: High production, heavy use 

4: Large hood or large air mass in motion 4: Small hood-local control only 

Simple theory shows that air velocity falls rapidly with distance away from the opening of a simple extraction pipe. Velocity generally 

decreases with the square of distance from the extraction point (in simple cases). Therefore the air speed at the extraction point should be 

adjusted, accordingly, after reference to distance from the contaminating source. The air velocity at the extraction fan, for example, should be 

a minimum of 4-10 m/s (800-2000 f/min) for extraction of crusher dusts generated 2 meters distant from the extraction point. Other 

mechanical considerations, producing performance deficits within the extraction apparatus, make it essential that theoretical air velocities are 

multiplied by factors of 10 or more when extraction systems are installed or used. 

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES 

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PHYSICAL PROPERTIES 

Solid. 

Mixes with water. 

Corrosive. 

Acid. 

State Divided solid Molecular Weight 97.10 

Melting Range (°F) 392- 401 Viscosity Not Applicable 

Boiling Range (°F) Decomposes @401 Solubility in water (g/L) Miscible 

Flash Point (°F) Not applicable pH (1% solution) 1.2 

Decomposition Temp (°F) Not Available pH (as supplied) Not applicable 

Autoignition Temp (°F) Not available. Vapour Pressure (mmHG) Not applicable 

Upper Explosive Limit (%) Not applicable Specific Gravity (water=1) 2.15 

Lower Explosive Limit (%) Not applicable Relative Vapor Density (air=1) Not applicable 

Volatile Component (%vol) Nil Evaporation Rate Not applicable 

APPEARANCE 

White crystalline (or brownish grey for technical grades), odourless solid. Non-hygroscopic. Soluble in water giving highly acid solutions. 

CONDITIONS CONTRIBUTING TO INSTABILITY 

! 

Contact with alkaline material liberates heat 

Presence of incompatible materials. 

Product is considered stable. 

Hazardous polymerization will not occur. 

Section 10 - CHEMICAL STABILITY 

STORAGE INCOMPATIBILITY 

! Sulfamic acid: 

reacts violently with chlorine, nitric acid, fuming nitric acid, strong bases, chlorine, hypochlorous acid, strong oxidising agents, sulfides, 

cyanides or when heated with nitrates, nitrites 

is strongly acidic in aqueous solution 

hydrolyses to ammonium bisulfate at elevated temperatures 

is incompatible with alkylene oxides, aliphatic amines, alkanolamines, amides, ammonia, epichlorohydrin, organic anhydrides, 

isocyanates, metal nitrates/ nitrites, oxidisers, vinyl acetate, common metals and their alloys, water 

Contact with metals may result in the evolution of hydrogen (H2) which can form explosive mixtures in air. 

Inorganic acids are generally soluble in water with the release of hydrogen ions. The resulting solutions have pH's of less than 7.0. 

Inorganic acids neutralize chemical bases (for example: amines and inorganic hydroxides) to form salts. 

Neutralization can generate dangerously large amounts of heat in small spaces. 

The dissolution of inorganic acids in water or the dilution of their concentrated solutions with additional water may generate significant 

heat. 

The addition of water to inorganic acids often generates sufficient heat in the small region of mixing to cause some of the water to boil 

explosively. The resulting "bumping" can spatter the acid. 

Inorganic acids react with active metals, including such structural metals as aluminum and iron, to release hydrogen, a flammable gas. 

Inorganic acids can initiate the polymerization of certain classes of organic compounds. 

Inorganic acids react with cyanide compounds to release gaseous hydrogen cyanide. 

Inorganic acids generate flammable and/or toxic gases in contact with dithiocarbamates, isocyanates, mercaptans, nitrides, nitriles, 

sulfides, and strong reducing agents. Additional gas-generating reactions occur with sulfites, nitrites, thiosulfates (to give H2S and SO3), 

dithionites (SO2), and even carbonates. 

Acids often catalyze (increase the rate of) chemical reactions. 

Avoid strong acids, bases. 

For incompatible materials - refer to Section 7 - Handling and Storage. 

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sulfamic acid 

Section 11 - TOXICOLOGICAL INFORMATION 

TOXICITY AND IRRITATION 

! unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances. 

TOXICITY 

Oral (rat) LD50: 3160 mg/kg 

IRRITATION 

Skin (human): 4 %/5 days (I)- Mild 

Skin (rabbit): 500 mg/24 h-SEVERE 

Eye (rabbit): 250 ug/24 h - SEVERE 

Eye (rabbit): 20 mg - Moderate 

! The material may produce severe irritation to the eye causing pronounced inflammation. Repeated or prolonged exposure to irritants may 

produce conjunctivitis. 

The material may cause severe skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the 

production of vesicles, scaling and thickening of the skin. Repeated exposures may produce severe ulceration. 

Asthma-like symptoms may continue for months or even years after exposure to the material ceases. This may be due to a non-allergenic 

condition known as reactive airways dysfunction syndrome (RADS) which can occur following exposure to high levels of highly irritating 

compound. Key criteria for the diagnosis of RADS include the absence of preceding respiratory disease, in a non-atopic individual, with 

abrupt onset of persistent asthma-like symptoms within minutes to hours of a documented exposure to the irritant. A reversible airflow 

pattern, on spirometry, with the presence of moderate to severe bronchial hyperreactivity on methacholine challenge testing and the lack of 

minimal lymphocytic inflammation, without eosinophilia, have also been included in the criteria for diagnosis of RADS. RADS (or asthma) 

following an irritating inhalation is an infrequent disorder with rates related to the concentration of and duration of exposure to the irritating 

substance. Industrial bronchitis, on the other hand, is a disorder that occurs as result of exposure due to high concentrations of irritating 

substance (often particulate in nature) and is completely reversible after exposure ceases. The disorder is characterised by dyspnea, cough 

and mucus production. 

Section 12 - ECOLOGICAL INFORMATION 

Refer to data for ingredients, which follows: 

SULFAMIC ACID: 

! Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. 

! Do NOT allow product to come in contact with surface waters or to intertidal areas below the mean high water mark. Do not contaminate 

water when cleaning equipment or disposing of equipment wash-waters. 

Wastes resulting from use of the product must be disposed of on site or at approved waste sites. 

! Although inorganic chloride ions are not normally considered toxic they can exist in effluents at acutely toxic levels (chloride >3000 mg/l). 

the resulting salinity can exceed the tolerances of most freshwater organisms. 

Inorganic chlorine eventually finds its way into the aqueous compartment and as such is bioavailable. Incidental exposure to inorganic 

chloride may occur in occupational settings where chemicals management policies are improperly applied. The toxicity of chloride salts 

depends on the counter-ion (cation) present; that of chloride itself is unknown. Chloride toxicity has not been observed in humans except in 

the special case of impaired sodium chloride metabolism, e.g. in congestive heart failure . Healthy individuals can tolerate the intake of large 

quantities of chloride provided that there is a concomitant intake of fresh water. 

Although excessive intake of drinking-water containing sodium chloride at concentrations 

above 2.5 g/litre has been reported to produce hypertension, this effect is believed to be related to the sodium ion concentration. 

Chloride concentrations in excess of about 250 mg/litre can give rise to detectable taste in water, but the threshold depends upon the 

associated cations. Consumers can, however, become accustomed to concentrations in excess of 250 mg/litre. No health-based guideline 

value is proposed for chloride in drinking-water. 

In humans, 88% of chloride is extracellular and contributes to the osmotic activity of body fluids. The electrolyte balance in the body is 

maintained by adjusting total dietary intake and by excretion via the kidneys and gastrointestinal tract. Chloride is almost completely 

absorbed in normal individuals, mostly from the proximal half of the small intestine. Normal fluid loss amounts to about 1.5?2 liters/day, 

together with about 4 g of chloride per day. Most (90 - 95%) is excreted in the urine, with minor amounts in faeces (4- %) and sweat (2%) 

Chloride increases the electrical conductivity of water and thus increases its corrosivity. In metal pipes, chloride reacts with metal ions to form 

soluble salts thus increasing levels of metals in drinking-water. In lead pipes, a protective oxide layer is built up, but chloride enhances 

galvanic corrosion. It can also increase the rate of pitting corrosion of metal pipes. 

! Prevent, by any means available, spillage from entering drains or watercourses. 

! DO NOT discharge into sewer or waterways. 

Ecotoxicity 

Ingredient Persistence: Water/Soil Persistence: Air Bioaccumulation Mobility 

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sulfamic acid HIGH LOW HIGH 

Section 13 - DISPOSAL CONSIDERATIONS 

US EPA Waste Number & Descriptions 

A. General Product Information 

Corrosivity characteristic: use EPA hazardous waste number D002 (waste code C) 

Disposal Instructions 

All waste must be handled in accordance with local, state and federal regulations. 

" Legislation addressing waste disposal requirements may differ by country, state and/ or territory. Each user must refer to laws operating in 

their area. In some areas, certain wastes must be tracked. 

A Hierarchy of Controls seems to be common - the user should investigate: 

Reduction 

Reuse 

Recycling 

Disposal (if all else fails) 

This material may be recycled if unused, or if it has not been contaminated so as to make it unsuitable for its intended use. Shelf life 

considerations should also be applied in making decisions of this type. Note that properties of a material may change in use, and recycling or 

reuse may not always be appropriate. 

DO NOT allow wash water from cleaning equipment to enter drains. Collect all wash water for treatment before disposal. 

Recycle wherever possible. 

Consult manufacturer for recycling options or consult Waste Management Authority for disposal if no suitable treatment or disposal facility 

can be identified. 

Treat and neutralize at an approved treatment plant. 

Treatment should involve: Mixing or slurrying in water Neutralization with soda-lime or soda-ash followed by: Burial in a licensed land-fill 

or Incineration in a licensed apparatus (after admixture with suitable combustible material) 

Decontaminate empty containers with 5% aqueous sodium hydroxide or soda ash, followed by water. Observe all label safeguards until 

containers are cleaned and destroyed. 

Section 14 - TRANSPORTATION INFORMATION 

DOT: 

Symbols: None Hazard class or Division: 8 

Identification Numbers: UN2967 PG: III 

Label Codes: 8 Special provisions: IB8, IP3, T1, TP33 

Packaging: Exceptions: 154 Packaging: Non-bulk: 213 

Packaging: Exceptions: 154 

Quantity Limitations: Cargo 

aircraft only: 

Vessel stowage: Other: 

Quantity limitations: Passenger 

aircraft/rail: 

100 kg Vessel stowage: Location: A 

None 

Hazardous materials descriptions and proper shipping names: 


Air Transport IATA: 

ICAO/IATA Class: 8 ICAO/IATA Subrisk: None 

UN/ID Number: 2967 Packing Group: III 

25 kg 

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sc-203409 


Special provisions: 

None 

Shipping Name: SULPHAMIC ACID 

Maritime Transport IMDG: 

IMDG Class: 8 IMDG Subrisk: None 

UN Number: 2967 Packing Group: III 

EMS Number: F-A,S-B Special provisions: None 

Limited Quantities: 

Shipping Name: SULPHAMIC ACID 

5 kg 

Section 15 - REGULATORY INFORMATION 

sulfamic acid (CAS: 5329-14-6) is found on the following regulatory lists; 

"Canada Domestic Substances List (DSL)","Canada Ingredient Disclosure List (SOR/88-64)","Canada Toxicological Index Service - 

Workplace Hazardous Materials Information System - WHMIS (English)","Canada Toxicological Index Service - Workplace Hazardous 

Materials Information System - WHMIS (French)","International Council of Chemical Associations (ICCA) - High Production Volume 

List","OECD Representative List of High Production Volume (HPV) Chemicals","US - New Jersey Right to Know Hazardous Substances","US 

DOE Temporary Emergency Exposure Limits (TEELs)","US Food Additive Database","US Toxic Substances Control Act (TSCA) - Inventory" 

LIMITED EVIDENCE 

! Cumulative effects may result following exposure*. 

! May produce discomfort of the respiratory system*. 

! Eye contact may produce serious damage*. 

* (limited evidence). 

Section 16 - OTHER INFORMATION 

Reasonable care has been taken in the preparation of this information, but the author makes no warranty of 

merchantability or any other warranty, expressed or implied, with respect to this information. The author makes no 

representations and assumes no liability for any direct, incidental or consequential damages resulting from its use. 

For additional technical information please call our toxicology department on +800 CHEMCALL. 

! Classification of the mixture and its individual components has drawn on official and authoritative sources as well as independent review by 

the Chemwatch Classification committee using available literature references. 

A list of reference resources used to assist the committee may be found at: 

www.chemwatch.net/references. 

! The (M)SDS is a Hazard Communication tool and should be used to assist in the Risk Assessment. Many factors determine whether the 

reported Hazards are Risks in the workplace or other settings. Risks may be determined by reference to Exposures Scenarios. Scale of use, 

frequency of use and current or available engineering controls must be considered. 

This document is copyright. Apart from any fair dealing for the purposes of private study, research, review or 

criticism, as permitted under the Copyright Act, no part may be reproduced by any process without written 

permission from CHEMWATCH. TEL (+61 3) 9572 4700. 

Issue Date: Jul-30-2009 

Print Date:May-6-2010 

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Sulfamic acid - Santa Cruz Biotechnology

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