Q4_Test_Epic Cell based SS.qxd - Corning Incorporated

Corning ® Epic ® System
References
Research Publications/Book References
The C-Terminal Tail of CRTH2 is a Key Molecular Determinant
That Constrains Ga i
and Downstream Signaling Cascade Activation.
Schröder, R., Merten, N., Mosolff Mathiesen, J., Martini, L.,
Kruljac-Letunic, A., Krop, F., Blaukat, A., Fang, Y., Tran, E.,
Ulven, T., Drewke, C., Whistler, J., Pardo, L., Gomeza, J.,
Kostenis, E. University of Bonn, Zealand Pharma A/S,
University of California San Francisco, Merck Serono,
Corning Incorporated, University of Southern Denmark,
Universitat Autonoma de Barcelona. The Journal of Biological
Chemistry. 2009, 284(2): 1324-1336.
Dualistic GPCR Targeting: A Novel Route to Binding and Signaling
Pathway Selectivity. Antony, J., Kellershohn, K., Mohr-Andrä,
M., Kebig, A., Prilla, S., Muth, M., Heller, E., Disingrini, T.,
Dallanoce, C., Bertoni, S., Schrobang, J., Trankle, C., Kostenis,
E., Christopoulos, A., Höltje, H.-D., Barocelli, E., De Amici,
M., Holzgrabe, U., Mohr, K. University of Bonn, University
of Milan, University of Parma, Heinrich-Heine-University,
Monash University. FASEB Journal. 2009, 23(2): 442-450.
Discovery of Potent and Selective Agonists for the Free Fatty Acid
Receptor 1 (FFA 1
/GPR40), a Potential Target for the Treatment
of Type II Diabetes. Christiansen, E., Urban, C., Merten, N.,
Liebscher, K., Karlsen, K.K., Hamacher, A., Spinrath, A.,
Bond, A.D., Drewke, C., Ullrich, S., Kassack, M.U., Kostenis,
E., Ulven, T. University of Bonn, University of Southern
Denmark, University of Tuebingen, University of Düsseldorf.
Journal of Medicinal Chemistry. 2008, 51(22): 7061-7064.
Duplexed Label-Free G Protein Coupled Receptor Assays for High-
Throughput Screening. Tran, E., Fang, Y. Journal of Biomolecular
Screening. 2008, 13(10): 975-985.
Label-Free Biosensors. Cunningham, B., Karlsson, R., Rich, R.,
Myszka, D., Markey, F., Huber, W., Fang, Y., Fang, J., Tran,
E., Xie, X., Hallstrom, M., Frutos, A., Borwn, R., Brandts,
M., O’Brien, R, Peters, W., McGuinness, R., Verdonk, E.
(Cooper M, eds.), University of Cambridge Press. 2008.

Evaluation of Dynamic Mass Redistribution Technology for
Pharmacological Studies of Recombinant and Endogenously
Expressed G Protein-Coupled Receptors. Lee, P., Gao, A.,
van Staden, C., Ly, J., Salon, J., Xu, A., Fang, Y., Verkleeren,
R. Amgen and Corning Incorporated. Assay and Drug
Development Technologies. 2007, 6(1): 83-94.
Non-Invasive Optical Biosensor for Probing Cell Signaling.
Fang, Ye. Sensors. 2007, 7(10): 2316-2329.
Non-Invasive Optical Biosensor for Assaying Endogenous G
Protein-Coupled Receptors in Adherent Cells. Fang, Y., Li, G.,
Ferrie, A. Journal of Pharmacological and Toxicological Methods.
2007, 55(3): 314-322.
Label-Free High-Throughput Functional Lytic Assays. O’Malley,
S., Xie, Y., Frutos, A. Journal of Biomolecular Screening. 2007,
12(1): 117-125.
Optical Biosensor Differentiates Signaling of Endogenous PAR1
and PAR2 in A431 Cells. Fang, Y., Ferrie, A. BMC Cell Biology.
2007, 8(24).
Systems Biology and Systems Pharmacology of b2-Adrenergic
Receptors in Human Epidermoid Carcinoma Cells. Fang, Y.,
Ferrie, A., Lahiri, J. Trends in Signal Transduction Research.
2007: 145-171.
Label-Free Cell-Based Assays with Optical Biosensors in Drug
Discovery. Fang, Y. Assay and Drug Development Technologies.
2006, 4(5): 583-595.
Phospho-Specific Recognition by 14-3-3 Proteins and Antibodies
Monitored by a High Throughput Label-free Optical Biosensor.
Wu, M., Coblitz, B., Shikano, S., Long, S., Spieker, M.,
Frutos, A., Mukhopadhyay, S., Li, M. FEBS Letters. 2006,
580(24): 5681-2689.
Resonant Waveguide Grating Biosensors for Living Cell
Sensing. Fang, Y., Ferrie, A., and Fontaine, N., Mauro, J.,
Balakrishnan, J. Biophysical Journal. 2006, 91(5): 1925-1940.
Label-Free Profiling of Endogenous G Protein-Coupled Receptors
Using a Cell-based High Throughput Screening Technology Fang,
Y., Ferrie, A., Li, G. Journal of the Association for Laboratory
Automation. 2006, 11(4): 181-187.
Cellular Functions of Cholesterol Probed with Optical Biosensors.
Fang, Y., Ferrie, A., Li, G. Biochimica et Biophysica Acta-
Molecular Cell Research. 2006, 1763(2): 254-261.
Optical Biosensor Provides Insights for Brandykinin B2 Receptor
Signaling in A431 Cells. Fang, Y., Li, G., Peng, J. FEBS Letters.
2005, 579(28): 6365-6374.
Characteristics of Dynamic Mass Redistribution of EGF Receptor
Signaling in Living Cells Measured with Label-Free Optical
Biosensors. Fang, Y., Ferrie, A., Fontaine, N., Yuen, P.
Analytical Chemistry. 2005, 77(17): 5720-5725.
Optical Biosensors for Monitoring Dynamic Mass Redistribution
in Living Cells Mediated by Epidermal Growth Factor Receptor
Activation. Fang, Y., Ferrie, A., Fontaine, N., Yuen, P. Annual
International Conference of the IEEE Engineering in Medicine and
Biology-Proceedings 7 VOLS, art. No. 1616501: 666-669.
Probing Cytoskeleton Modulation by Optical Biosensors. Fang, Y.,
Ferrie, A., Li, G. FEBS Letters. 2005, 579(19): 4175-4180.
Self-Referencing a Single Waveguide Grating Sensor in a Micron
sized Deep Flow Chamber for Label-Free Biomolecular Binding
Assays. Yuen, P., Fontaine, N., Quesada, M., Mazumder, P.,
Bergman, R., Mozdy, E. Lab on a Chip-Miniaturization for
Chemistry and Biology. 2005, 5(9): 959-965.
Scientific Posters
Development of a Fragment Screen with the Corning ® Epic ®
System using both a Direct Binding and a Competition Approach.
Leavitt, S., Golde, J., Schultz, B.E., Pagratis, N. Cambridge
Healthtech Institute Fragment-Based Drug Discovery. April 2009.
A Bona Fide Label-Free HTS Campaign to Identify Agonist
Compounds Using the Corning Epic System. Scibek, J., Randle,
D., Romeo, L., Wang, C., Xu, A., Hamid, R., Truitt, T.,
Garippa, R. Roche and Corning Incorporated. American
Lab Automation Conference. January 2009.
Use of Label-Free Optical Biosensors to Detect Ion Channel Interactions
in Intact Cells. Fleming, M., Li, F., Gao, A., Marala, R.,
Kaczmarek, L. Yale University and Corning Incorporated.
Ion Channel Targets Conference. September 2008.
Development of an Antibody-Sandwich Assay for Hybridoma
Screening Using the Corning Epic System. Scibek, J., Xu, A.,
Kaluza, K., Frutos, A. Roche and Corning Incorporated.
Society for Biomolecular Sciences Label-Free Symposium. June
2008.
Small Molecule HTS Hit Validation with Biophysical /Label-Free
SPR Binding Assays in Lead Finding for an Orphan Nuclear
Receptor. Acker, V., Esser, O., Barlier, D., Bernet P., Tirat-
Boeuf, A., Leder, L., Bergsdorf, C., Ottl, J. Novartis. Society
for Biomolecular Sciences Label-Free Symposium. June 2008.
Microtiter-Plate Based Screening for Direct Binding of Small
Molecules on Target Proteins-A Comparison of EPIC and ProteOn
XPR36 for Fragment Based Screening and Hit Characterization.
Esser, O., Acker, V., Barlier, D., Eckelt, V., Vespermann, U.,
Frutos, A., Shedd, G., Bravman, T., Shafir, T., Ottl, J. Novartis
and Corning Incorporated. Society for Biomolecular Sciences
Label-Free Symposium. June 2008.
Epic Cell Assays for Probing Endogenous Ion Channels. Sun, H.,
Ferrie, A., Fang, Y. Corning Incorporated. Society for Biomolecular
Sciences Label-Free Symposium. June 2008.
A High Throughput Small Molecule Binding Assay for Human
Trypsin on the Corning Epic System. Rawlins, P., To Van, D.,
Coldwell, M. AstraZeneca and Corning Incorporated. Society
for Biomolecular Sciences Label-Free Symposium. June 2008.
2

Label-Free Optical Biosensor for Probing Receptor Biology: Theory,
Modeling and Applications. Fang, Y., Ferrie, A., Tran, E., Li, G.,
Verrier, F., Xi, J., Soni, M. Corning Incorporated. Society for
Biomolecular Sciences Conference. April 2008.
Detection of Ligand-Dependent Interaction of Nuclear Receptors
with their Cofactor Using the Corning ® Epic ® System. Kober, I.,
Fang, J., Gleitz, J., Frutos, A. Merck Serono and Corning
Incorporated. Society for Biomolecular Sciences Conference.
April 2008.
Label-Free Optical Biosensor for Probing the Roles of Adenylate
Cyclases in Signaling Integration of G Protein-Coupled Receptors.
Tran, E., Fang, Y. Corning Incorporated. Society for Biomolecular
Sciences Conference. April 2008.
Label-Free Optical Biosensor for Probing GPCR Ligand-Directed
Functional Selectivity. Ferrie, A., Fang, Y. Corning Incorporated.
Society for Biomolecular Sciences Conference. April 2008.
Antibody Screening Sandwich Assay by Label-Free Epic Technology.
Scibek, J., Xu, A., Kaluza, K., Frutos, A. Roche and Corning
Incorporated. Society for Biomolecular Sciences Conference.
April 2008.
Label-Free Optical Biosensor for Probing GPCR Ligand-Directed
Functional Selectivity. Fang, Y., Ferrie, A., Torvinen, M.
Corning Incorporated. Screening Europe. February 2008.
Label-Free Cell-Based Screening of an Endogenous GPCR Using
the Corning Epic System. Scibek, J., Frutos, A., Randle, D.
Association for Laboratory Automation Conference. January 2008.
Label-Free Detection for Compound Screening Using the Corning
Epic System. Vespermann, U., Xie, X., Bunch, T., Frutos, A.,
Randle, D., Scibek, J. Corning Incorporated. Enhancing
Primary and Secondary Screening Congress. November 2007.
Development of a 384-Well Small Molecule Binding Assay for
Trypsin on the Epic Label-Free Reader. Rawlins, P., Dodgson, K.,
To Van, D., Coldwell, M. AstraZeneca R&D Charnwood, and
Corning Incorporated. ELRIG Conference. October 2007.
Label-Free Cell-Based Screening for GPCR Agonists and
Antagonists of the b2 Adrenergic Receptor Using the Corning Epic
System. Scibek, J., Randle, D., Bunch, T., Frutos, A. Corning
Incorporated. Drug Discovery & Development of Innovative
Therapeutics (DDT) World Congress. August 2007.
Physiologically Relevant Label-Free Cell-Based Assays for High-
Throughput Screening. Scibek, J., Frutos, A., Randle, D.,
Bunch, T., Fang, Y. Merck Technology Symposium. May 2007.
Podium Presentations
Cellular Dynamic Mass Redistribution Reveals Biased Signaling
of A Novel Class of GPCR Activators. Kebig, A. University
of Bonn. German Association of Pharmacology and Toxicology
Conference. February 2009.
Application of Label-Free Cell-Based Assay in Lead Generation.
Xin, H. American Lab Automation. January 2009.
Application of Epic System in Cell-Based Assays. Xin, H. Johnson
& Johnson. World Pharmaceutical Congress. April 2008.
Application of the Corning Epic System to Label-Free Functional
GPCR Assays. Dodgson, K. AstraZeneca. ELRIG/SBS, 2008
The Epic System: A Label-Free Screening Platform. Dunne, A.
GlaxoSmithKline. American Lab Automation Conference.
January 2008.
Use of Label-Free Detection Technologies in the Hit-to-Lead
Process. Stuhmeier, F. Pfizer. High Content Analysis Conference.
January 2009.
Evolution of Label-Free Screening on the Corning Epic System.
Coldwell, M. Novartis. Society for Biomolecular Sciences Label-
Free Symposium. June 2008.
Productive and Promiscuous Hits Biophysic/Label-Free Assays
in Hit Discovery and Verification. Ottl, J. Novartis. Society for
Biomolecular Sciences Label-Free Symposium. June 2008.
Use of Label-Free Detection Technologies in the Hit-to-Lead
Process. Stuhmeier, F. Pfizer. Society for Biomolecular Sciences
Label-Free Symposium. June 2008.
Application of Label-Free Detection to HTS Using Live Cells
Expressing Endogenous GPCRs. Rocheville, M., GlaxoSmithKline.
Society for Biomolecular Sciences Conference. April 2008.
Label-Free Optical Biosensor for Probing GPCR Ligand-Directed
Functional Selectivity. Ferrie, A., Fang, Y. Corning Incorporated.
Society for Biomolecular Sciences Conference. April 2008.
Label-Free Optical Biosensor for Probing Receptor Biology: Theory,
Modeling and Applications. Fang, Y., Ferrie, A., Tran, E., Li, G.,
Verrier, F., Xi, J., Soni, M. Society for Biomolecular Sciences
Conference. April 2008.
Label-Free Optical Biosensor for Probing the Roles of Adenylate
Cyclases in Signaling Integration of G Protein-Coupled Receptors.
Tran, E., Fang, Y. Corning Incorporated. Society for Biomolecular
Sciences Conference. April 2008.
Detection of Ligand-Dependent Interaction of Nuclear Receptors
with their Cofactor Using the Corning Epic System. Kober, I.,
Fang, J., Gleitz, J., Frutos, A. Merck Serono and Corning
Incorporated. Society for Biomolecular Sciences Conference.
April 2008.
Antibody Screening Sandwich Assay by Label-Free Epic Technology.
Scibek, J., Xu, A., Kaluza, K., Frutos, A. Roche and Corning
Incorporated. Society for Biomolecular Sciences Label-Free
Symposium. June 2008.
Epic System Evaluation May/June 2007. Clark, L., Coma-Fort,
I., Daniels, D., Dunne, A., Green, P., Jerman, J., Martin, J.,
Rees, S., Rocheville, M., Wise, A. GlaxoSmithKline. 2007.
Application of the Corning Epic System to Label-Free Functional
GPCR Assays. Dodgson, K., Novartis. ELRIG/SBS. October
2007.
3

Study of Small-Molecule/Protein Interactions Using the Corning ®
Epic ® System. Ottl, J., Fang, J., Leder, L., Frutos, A. Novartis
and Corning Incorporated. MIPTEC. May 2007.
Analysis of Protein/Small Molecule Interactions Using the Corning
Epic System. Xie, X., Huang, W., Liu, X., Frutos, A. Gilead
and Corning Incorporated. Society for Biomolecular Sciences
Conference. April 2007.
Phosphorylation Profiling: High-Throughput Label-Free Detection
of Protein-Protein Interactions Using the Epic System. Wu, M.
Johns Hopkins University. Society for Biomolecular Sciences
Conference. September 2006.
Overview Articles
Cell-Based Assays Get Mechanized. Dove, A. Bioscience
Technology. 2009.
Corning Hopes to Expand Epic Label-Free Technology. LoBuono,
C. Cell-Based Assay News. November 2008.
Real-Time Cellular Response: Label-Free Optical Biosensors Can
Shed New Light on Cell Biology. Marala, R., Hallstrom, M.
Corning Incorporated. Drug Discovery & Development.
July 2008.
Overcoming the Limitations of Conventional GPCR Assays with
a Label-Free System. Hallstrom, M., Marala, R. Corning,
Incorporated. American Biotechnology Laboratory. June/July
2008.
Comparison of Cell-Based Label Free Detection Tools. Minor, L.
American Drug Discovery. 2007, 2(5): 14-18.
Biotech Revolution. Quain, John R. NYSE Magazine. 27
November 2007.
Naked Proteomics. Shaffer, C. Drug Discovery & Development.
1 October 2007.
Corning Targets Screening & Cell Growth. Potera, C. Genetic
Engineering News. 1 September 2007.
A High-Throughput Label-Free Screening Platform for Biochemical
and Cell-Based Assays. Verkleeren, R., Frutos, A., Fang, Y.,
Fang, J., Guangshan, L. American Biotechnology Laboratory.
October 2006: 16.
Physiologically Relevant HTS Technologies: Corning Epic System
Eliminates Chemical Labels and Permits Cell-Based Screening.
Verkleeren, R., Frutos, A., Fang, Y., Fang, J., Guangshan, L.
Genetic Engineering News. 1 September 2006: 32.
Going a Label-Free Route with Biosensors. Shaffer, C. Genetic
Engineering News. 15 June, 2006.
For additional product or technical information, please visit www.corning.com/ lifesciences/epic,
or call 800.492.1110, or e-mail at epic@corning.com. Customers outside the United States, please call
+1.978.442.2200 or contact your local Corning sales office listed below.
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