Cun-Yu Wang DDS, Ph.D. Professor Nanjing Medical University BS ...

Principal Investigator/Program Director (Last, first, middle): Wang, Cun-Yu
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel in the order listed for Form Page 2.
Follow the sample format for each person. DO NOT EXCEED FOUR PAGES.
NAME
Cun-Yu Wang D.D.S., Ph.D.
POSITION TITLE
Professor
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
DEGREE
(if applicable)
YEAR(s)
FIELD OF STUDY
Nanjing Medical University B.S. 1980-1985 Stomatology
Perking University D.D.S. 1985-1989 Oral Medicine
Forsyth Institute/Harvard University Post. Doc. 1990-1995 Immunology
UNC at Chapel Hill Ph.D 1995-1998 Genet. Mol. Biol.
Selected peer-reviewed publications
• Wang, C.-Y., Stashenko, P.1991. Kinetics of bone resorbing activity in developing periapical lesions. J
Dent Res. 70: 1362-6
• Stashenko, P., Yu, S.W., Wang C.-Y. 1992. Kinetics of immune cell and bone resorption responses to
endodontics. J Endod.18: 422-426.
• Wang, C.-Y, Stashenko, P. 1993. Characterization of bone resorbing activity in human peirapical lesions.
J.Endod.19:107-11.
• Wang, C.-Y., Stashenko, P. 1993. The role of interleukin-1α in the pathogenesis of periapical bone
destruction in a rat model system. Oral Microbiol Immunol. 8: 50-56.
• Rahimi, P., Wang, C.-Y., Stashenko, P., and Graves, D.T. 1995. MCP-1 may account for monocyte
recruitment in bone. Endocrin.136: 2752-9.
• Teles, R., Wang, C.-Y., and Stashenko, P. 1997.Increased susceptibility of RAG-2 SCID mice to
dissemination of endodontic infection. Infect. Immun. 65:3781-3787.
• Wang, C.-Y., Mayo, M..W., and Baldwin, A.S. 1996. TNF- and cancer therapy-induced apoptosis:
potentiation by inhibition of NF-κB. Science. 274: 784-787.
• Wang, C.-Y., and Stashenko, P. 1997. Bone resorptive cytokine gene expression in developing periapical
lesions. Oral Microbiol. Immunol. 12:65-71.
• Goulet, J.L., Wang, C.-Y., and Koller, B.H. 1997. Modification of the MRL mouse genome using
embryonic stem cell lines derived from this murine model of autoimmune disease. J Immunol. 159:
4376-4381.
• Mayo, M.M., Wang, C.-Y., Cogswell, P.C., Rogers-Graham, K.S., Lowe, S.W., Der, C.J., and Baldwin,
A.S. 1997. Requirement of NF-κB activation to suppress p53-independent apoptosis induced by
oncogenic Ras. Science, 278: 1812-1815.
• Wang, C.Y.,* Mayo, M.M., and Baldwin, A.S*. 1998. Mechanism for cell resistance to TNFα: NF-κB
activates TRAF1 and 2 and c-IAP1 and 2 to suppress caspase-8-initiated apoptosis. Science 281:
1680-1683. *corresponding authors
• Wang, C.-Y., Cusack, J. Liu, R., and Baldwin, A.S. 1999. Control of inducible chemoresistance:
enhanced anti-tumor therapy via increased apoptosis through inhibition of NF-κB. Nature Medicine. 5:
412-417.
• Mayo, M.W., Wang, C.-Y., Drouin, S.S., Madrid, L.V., Marshall, A.F., Reed, J.C., Weissman, B.E., and
Baldwin, A.S. WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene.
EMBO J. 18: 3920-3935.
• Wang, C.-Y.*, Guttridge, D.C., Mayo, M.W., and Baldwin, A.S. 1999. NF-κB induces expression of the
Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol. Cell. Biol.
19: 5923-5929. Corresponding author
PHS 398/2590 (Rev. 05/01) Page __5____ Biographical Sketch Format Page

Principal Investigator/Program Director (Last, first, middle): Wang, Cun-Yu
• Madrid, L.V., Wang, C.-Y., Guttridge, D.C., Schottelius, A.J., Baldwin, A.S., and Mayo, M.W. 2000.
Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-κB.
Mol. Cell. Biol. 20:1626-1638.
• Guttridge, D.C., Mayo, M. W. Madrid, L.V., Wang, C.-Y., and Baldwin, A.S. 2000. NF-κB activation
induces the loss of MyoD mRNA: implications for cytokine-induced skeletal muscle dysfunction and
cachexia. Science. 289: 2363-2366.
• Sasaki, H., Hou, L., Belani, A., Wang, C.-Y., Uchiyama, T., Muller, R., Stashenko, P. IL-10 but not IL-4
suppresses infection-stimulated bone resorption in vivo. J. Immunol. 165:3626-3630.
• Chen, S. Guttridge, D.C., You, Z., Zhang, Z., Fribley, A., Kitajewski, J. Wang, C.-Y. 2001. Wnt-1
signaling inhibits apoptosis by activating β-catenin/Tcf-mediated transcription. J. Cell. Biol. 152: 87-96
• You, Z., Ouyang, H. Saims, D., and Wang, C.-Y. 2001. Nuclear factor-kappa B-inducible death effector
domain-containing protein suppresses TNF-mediated apoptosis by inhibiting caspase-8 activity. J. Biol.
Chem. 276: 26398-26404.
• Chen, S., Guttridge, D.C., Tang, E., Shi, S., Guan, K., and Wang, C.-Y. 2001. Suppression of tumor
necrosis factor-mediated apoptosis by nuclear factor κB-independent bone morphogenetic protein/Smad
signaling. J. Biol. Chem. 276: 39259-39263.
• Chen, S. Fribley, A., and Wang, C.-Y. 2002. Potentiation of Tumor Necrosis Factor-mediated Apoptosis
by adenovirus-mediated gene transfer of NF-κB inhibitor. J. Dent. Res.. 81:98-102.
• Reuther, J.Y., Kashatus, D., Davis, R., Westwick, J., Wang, C.-Y., and Baldwin, A.S. 2002. The
p65/RelA subunit of NF-κB suppresses sustained and anti-apoptotic JNK activity induced by TNF. Mol.
Cell. Biol. 22:8175-8183.
• Chen, H.L., Demiralp, B., Schneider, A., Koh, A.J., Silve, C., Wang, C.-Y., and McCauley, L.K.
Parathyroid hormone and parathyroid hormone related protein exert both pro- and anti-apoptotic effects
in
mesenchymal cells. J. Biol. Chem. 277:19374-19381.
• Zeng, Q., Chen, S. Carey, T., and Wang, C.-Y. 2002. Hepatocyte growth factor inhibits anoikis in human
head and neck squamous cell carcinoma by activation of ERK and Akt signaling independent of NF-κB.
J. Biol. Chem. 277:25203-25208.
• Shi, S., Gronthos, S., Chen, S., Counter, C., Robley, P.G., and Wang, C.-Y. 2002. Potentiation of bone
forming capacity of human post-natal bone marrow stromal stem cells in vivo by telomerase expression.
Nature Biotech. 20:587-591.
• You, Z., S. Chen, D. Saims, Z. Zhang, K. Guan, O, Macdougall, G. Evan, M. Brown, J. Kitajewiski, and
Wang C.-Y.. Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis.
J. Cell Biol. 157:429-440, 2002
• Zeng, Q., McCauley, L.K., and Wang, C.-Y. 2002. Hepatocyte growth factor inhibits anoikis by
induction of AP-1-dependent cyclooxygenase-2: implication in head and neck squamous cell carcinoma
progression. J. Biol. Chem. 277: 50137-50142
• You, Z., Madrid, L.V., Saims, D., Sedivy, J., and Wang, C.-Y. 2002. c-Myc sensitizes cells to
TNF-mediated apoptosis by inhibiting NF-κB transactivation. J. Biol. Chem. 277:36671-36677.
• Tang, E.D., Wang, C.-Y., and Guan, K. 2003. NEMO Ubiquitination is a critical event in the activation
of the IκB kinase complex by TNFα. J. Biol. Chem. 278: 37297-37305.
• Tang, E.D., Inohara, N., Wang, C.-Y., Nunez, G., and Guan, K. 2003. Roles for homotypic interactions
and transautophosphorylation in IKKβ activation. J. Bio. Chem. 278: 38566-38570.
• Yang, F., Tang, E., Guan, K., and Wang, C.-Y. 2003. IKKβ plays an essential role in the
phosphorylation of p65/RelA on serine 536 induced by LPS. J. Immunol. 170: 5630-5635.
• Simmons, C.A., Matlis, S., Thornton, A.J., Chen, S., Wang, C.Y., Mooney, D.J. 2003. Cyclic strain
enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular
signal-regulated kinase (ERK1/2) signaling pathway. J. Biomech. 36(8):1087-1096.
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Principal Investigator/Program Director (Last, first, middle): Wang, Cun-Yu
• Yang, Yamashita, J., Tang, E., Wang, H., Guan, K., and Wang, C.-Y. 2004. The zinc finger mutation
C417R of IκB kinaseγ impairs lipopolysaccharide- and TNF-mediated NF-κB activation through
inhibiting phosphorylation of the IκB kinase activation loop. J. Immunol. 172: 2446-2452.
• Seo, B. Miura, M., Gronthos, S., Bartold, P.M., Batoli, S., Brahim, J., Young, M., Robey, P.G., Wang,
C.-Y., and Shi, S. 2004. Multipotent postnatal stem cells from human periodontal ligament. Lancet. 364:
149-155.
• Kniazeva, M., Crawford, Q.T., Seiber, M., Wang, C.-Y., and Han, M. Mono methyl branched fatty
acids play essential role in C. elegans development. Plos. Biol. In press.
• Zhang, Z., and Wang, C.-Y. Wnt-induced clusterin inhibits apoptosis and promotes oncogenesis.
Nature. in revision.
PHS 398 (Rev. 05/01) Page _28_ Resources Format Page