Annual Report 2010 - University of Wisconsin Department of ...

Annual Report 2010 - University of Wisconsin Department of ...

Annual Report 2010 - University of Wisconsin Department of ...


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<strong>2010</strong><br />

ANNUAL<br />

REPORT<br />

<strong>2010</strong> ANNUAL REPORT<br />



Grants 21<br />

Year in Review<br />

Researcher Expands<br />

Retina Program<br />

Strong Connections<br />

Between Doctors & Patients<br />

A Day in the Life:<br />

Residency Prepares Doctors<br />

2<br />

6<br />

10<br />

14<br />

Clinical & Research Faculty<br />

& Staff 22<br />

Clinical Trials 24<br />

Publications 26<br />

Donor Honor Roll 30<br />

Volunteer & Affiliate<br />

Faculty Members 31<br />

Financial Highlights 31<br />

Donation Supports Care for<br />

Patients with AMD<br />



Each year in our annual<br />

report we share a few<br />

<strong>of</strong> the many wonderful<br />

stories from the <strong>University</strong><br />

<strong>of</strong> <strong>Wisconsin</strong> <strong>Department</strong> <strong>of</strong><br />

Ophthalmology and Visual<br />

Sciences. This year we<br />

illustrate examples <strong>of</strong> the<br />

interrelationship among the<br />

three facets <strong>of</strong> our mission:<br />

research, clinical care and<br />

education.<br />

Basic science researcher<br />

Aparna Lakkaraju, PhD, is<br />

making great strides as she<br />

seeks to understand macular degeneration<br />

at the cellular level. She has brought great<br />

enthusiasm and new ideas after having<br />

completed her doctorate at the <strong>University</strong><br />

<strong>of</strong> Minnesota and a post-doctoral fellowship<br />

at Cornell <strong>University</strong>. Dr. Lakkaraju is drawn<br />

to academic research because she enjoys<br />

working with collaborators who care for human<br />

patients. It is her goal to translate the research<br />

taking place in her laboratory to breakthroughs<br />

that improve patient care.<br />

Barbara Blodi, MD, is a clinical researcher<br />

who also sees patients with retina problems.<br />

Work like hers will one day translate the<br />

discoveries made in our laboratories directly<br />

to the patients in our clinics. Like many other<br />

physicians, Dr. Blodi is proud to work with the<br />

basic scientists and to teach residents and<br />

fellows who train at the UW.<br />

One <strong>of</strong> those residents is senior<br />

Timothy Daley, MD, who will<br />

continue in the <strong>Department</strong> as a<br />

fellow in pediatric ophthalmology<br />

and adult strabismus. Our<br />

most direct link to the future <strong>of</strong><br />

ophthalmology is educating the<br />

residents, fellows and medical<br />

students who pass through our<br />

doors. We are proud <strong>of</strong> their work.<br />

Equally important to us is the<br />

education <strong>of</strong> our patients,<br />

explaining the basics <strong>of</strong> disease<br />

or the translational research<br />

breakthroughs we are making.<br />

An example <strong>of</strong> this patient education is the<br />

biennial Age-related Macular Degeneration<br />

symposium, where more than 500 people<br />

come to learn about the disease. In addition<br />

to people with macular degeneration and their<br />

caregivers, we have connected with public<br />

<strong>of</strong>ficials who deepen their understanding<br />

<strong>of</strong> this disease. This helps them make and<br />

implement health policy more effectively.<br />

We are grateful, as always, to the donors who<br />

help further the work we do here. The new<br />

horizons and opportunities presented by the<br />

explosion <strong>of</strong> scientific knowledge stand in<br />

stark contrast to the difficulty <strong>of</strong> obtaining the<br />

decreasing federal funding to pursue them. We<br />

are fortunate to play a part in advancing vision<br />

science, and our basic science and clinical<br />

researchers continue to compete effectively<br />

for these grants. However, the generosity <strong>of</strong><br />

our donors has made the crucial difference in<br />

our department staying strong as we move to<br />

the future.<br />

Research, clinical care, and education all<br />

overlap to form a continuum <strong>of</strong> excellence. We<br />

are pleased to share this journey, and these<br />

stories, with you.<br />

Paul L. Kaufman, MD<br />

Peter A. Duehr Pr<strong>of</strong>essor<br />

and <strong>Department</strong> Chair<br />

UW <strong>Department</strong> <strong>of</strong> Ophthalmology<br />

and Visual Sciences<br />

<strong>University</strong> <strong>of</strong> <strong>Wisconsin</strong> School<br />

<strong>of</strong> Medicine and Public Health<br />

<strong>2010</strong> ANNUAL REPORT


New faculty/staff join<br />

<strong>Department</strong><br />

Cameron Parsa, MD, an<br />

ophthalmologist who specializes<br />

in pediatric ophthalmology and<br />

adult strabismus as well as in<br />

neuro-ophthalmology, joined the<br />

<strong>Department</strong> <strong>of</strong> Ophthalmology<br />

and Visual Sciences as associate<br />

pr<strong>of</strong>essor in September <strong>2010</strong>.<br />

“Neuro-ophthalmology is a very<br />

broad subspecialty,” he said.<br />

“While the advent <strong>of</strong> neuroimaging<br />

reduced the scope <strong>of</strong> the<br />

Cameron Parsa, MD<br />

field from one previously essential<br />

in accurately localizing many brain<br />

tumors, it is more focused today on observational studies<br />

<strong>of</strong> the optic disc and nerve fiber layer, visible structures<br />

beyond the resolution <strong>of</strong> the MRI. It requires not only<br />

understanding the ocular manifestations <strong>of</strong> systemic and<br />

various neurological conditions, as is commonly perceived,<br />

but also quite frequently, how to detect the more subtle<br />

variants <strong>of</strong> common ocular conditions such as oil-droplet<br />

cataracts or even dry eye syndrome, which can masquerade<br />

as more ominous entities.”<br />

Often problems manifest as misalignment <strong>of</strong> the eyes,<br />

which ties in with Dr. Parsa’s other subspecialty, pediatric<br />

ophthalmology and adult strabismus.<br />

Cameron Parsa, MD, examines eye movements that would specifically pinpoint a brain anomaly in Ariana Cabrera, who<br />

traveled from Beloit, <strong>Wisconsin</strong>, to see a specialist at UW Health Eye Clinic. Dr. Parsa is both a pediatric ophthalmologist<br />

and a neuro-ophthalmologist.<br />

Dr. Parsa joined the <strong>Department</strong> after spending six<br />

years at The Krieger Children’s Eye Center <strong>of</strong> the Wilmer<br />

Ophthalmological Institute at The Johns Hopkins Hospital in<br />

Baltimore, Maryland, where he previously also worked in The<br />

Johns Hopkins Center for Hereditary Eye Diseases.<br />

2<br />


Selected Faculty<br />

Awards <strong>2010</strong><br />

In addition to his clinical practices, he<br />

conducts clinical and theoretic research<br />

designed to immediately impact the clinical<br />

practice <strong>of</strong> ophthalmology. His recent<br />

publications describe the demonstration <strong>of</strong><br />

an individual’s systemic inherited potential<br />

for angiogenesis via the analysis <strong>of</strong> optic<br />

nerve findings in various syndromes, the<br />

origin <strong>of</strong> port-wine stains, glaucoma and<br />

seizures in the Sturge-Weber syndrome and<br />

related diseases as simply due to venous<br />

dysplasia, and the nature <strong>of</strong> optic gliomas.<br />

His research has recently determined<br />

that this juvenile brain tumor represents<br />

a hamartoma rather than a neoplasm and<br />

that treatments now given for this tumor are<br />

actually ineffective and increase the risk <strong>of</strong><br />

malignant transformation later in life.<br />

Dr. Parsa sees patients at UW Health<br />

<strong>University</strong> Station Eye Clinic in Madison and<br />

Affinity Ophthalmology Offices in Menasha.<br />

Cameron Parsa, MD, looks over images for a patient<br />

with Darla Coullard, an ophthalmologic technician<br />

at UW Health <strong>University</strong> Station Eye Clinic. Having<br />

and keeping old images on file allows for helpful<br />

comparisons during the examination and to assess for<br />

any disease or progression.<br />

Richard Patterson, OD, joined the<br />

<strong>Department</strong> in March <strong>2010</strong>. He had<br />

previously worked in private optometry<br />

practice.<br />

Dr. Patterson brings<br />

experience with<br />

optics to the practice<br />

<strong>of</strong> optometry. “The<br />

science <strong>of</strong> optics<br />

is complex,” Dr.<br />

Patterson said,<br />

“and our patients<br />

consistently wanted<br />

to know more about<br />

their lens correction<br />

in a way they<br />

Richard Patterson, OD<br />

could understand.<br />

I discovered that I<br />

could relate their changes in eyesight in a<br />

non-technical way that helped them get a<br />

better handle on it. To me, that was the spark<br />

that led to my wanting to pursue my doctor<br />

<strong>of</strong> optometry training.<br />

“It was all about developing the relationship<br />

with a patient.”<br />

Dr. Patterson attended Indiana <strong>University</strong> –<br />

Bloomington to earn his doctor <strong>of</strong> optometry<br />

degree. He and his family moved to Madison<br />

in 2001 where he began to serve several<br />

Southern <strong>Wisconsin</strong> communities with his<br />

optical and optometric skills. In addition<br />

to providing clinical care to keep patients’<br />

eyes healthy, Dr. Patterson maintains<br />

his strong interest in optics, and enjoys<br />

being part <strong>of</strong> a full-service medical clinic<br />

delivering comprehensive eye care to the<br />

community and partnering with UW Health<br />

ophthalmologists and opticians.<br />

Best Doctors in America<br />

Gregg A. Heatley, MD<br />

Paul L. Kaufman, MD<br />

Burton J.Kushner, MD<br />

Leonard A. Levin, MD<br />

Castle Connolly Top Doctors<br />

Daniel M. Albert, MD, MS<br />

Paul L . Kaufman, MD<br />

Burton J. Kushner, MD<br />

Todd W. Perkins, MD<br />

Consumer’s Research Council <strong>of</strong><br />

America’s Top Ophthalmologists<br />

Mark J. Lucarelli, MD<br />

Fellow <strong>of</strong> the Association for Research<br />

in Vision and Ophthalmology<br />

Leonard A. Levin, MD (Gold)<br />

Robert W. Nickells, PhD (Silver)<br />

T. Michael Nork, MD, MS (Silver)<br />

<strong>2010</strong> ANNUAL REPORT<br />


YEAR IN REVIEW continued<br />

Labs moved for<br />

mentoring<br />

When a new researcher, such as Aparna<br />

Lakkaraju, PhD, joins the <strong>Department</strong> <strong>of</strong><br />

Ophthalmology and Visual Sciences, a formal<br />

mentoring committee is set up to provide<br />

support and advice.<br />

In Dr. Lakkaraju’s<br />

case, one <strong>of</strong> the<br />

researchers on<br />

her mentoring<br />

committee, Curtis<br />

Brandt, PhD, moved<br />

his laboratory<br />

space next to<br />

Dr. Lakkaraju’s<br />

laboratory in the<br />

Medical Sciences<br />

Center (the old<br />

Aparna Lakkaraju, PhD<br />

<strong>University</strong> Hospital)<br />

to facilitate collaboration and a supportive<br />

relationship. It also allows Dr. Brandt and<br />

his staff to have access to state-<strong>of</strong>-the art<br />

technology <strong>of</strong> new laboratory space.<br />

In the past, many new faculty created their<br />

own informal mentoring relationships.<br />

The mentoring committee is established<br />

to provide formal support to new faculty<br />

members. A formal system ensures that new<br />

faculty have a team dedicated to helping<br />

grow research opportunities.<br />

Curtis Brandt, PhD, and Aparna Lakkaraju, PhD, <strong>of</strong>ten discuss research projects during the course <strong>of</strong> their work days.<br />

Collaboration is facilitated by Dr. Brandt moving his labratory into space next to Dr. Lakkaraju’s new laboratory.<br />

4<br />


New Director leads<br />

residency program<br />

Stephen Sauer,<br />

MD, took over<br />

leadership <strong>of</strong> the<br />

<strong>Department</strong>’s<br />

Residency<br />

Program in July<br />

<strong>2010</strong>, when<br />

Yasmin Bradfield,<br />

MD, stepped<br />

down after leading<br />

us to successful<br />

reaccreditation<br />

Stephen Sauer, MD<br />

in 2009. Dr.<br />

Sauer served<br />

as director <strong>of</strong><br />

Core Competencies, a key aspect <strong>of</strong> the<br />

residency program, and brings a wealth <strong>of</strong><br />

education experience to the role. He will<br />

build on a program that is stronger than<br />

ever, expanding and adding rotations and<br />

preparing for international service for our<br />

residents.<br />

Dr. Sauer was awarded the <strong>University</strong> <strong>of</strong><br />

<strong>Wisconsin</strong> Hospitals and Clinics Program<br />

Director Administrative Fellowship<br />

in <strong>2010</strong>.<br />

Electronic<br />

Medical Record<br />

impleMented<br />

The <strong>Department</strong> took its first steps toward<br />

implementing an electronic medical<br />

record (EMR) system in <strong>2010</strong>. Although<br />

groundwork began several years earlier,<br />

in <strong>2010</strong> the first clinicians began using the<br />

Epic-designed system. UW Health has<br />

rolled out this EMR to all departments,<br />

allowing physicians and patients to have<br />

access to medical records throughout the<br />

organization.<br />

Optometrists and comprehensive<br />

ophthalmologists use the medical record<br />

system for documenting patient exams. The<br />

system will be rolled out to subspecialists<br />

in 2012.<br />

An ophthalmology technician enters patient<br />

information into UW Health’s electronic medical<br />

record system. This kind <strong>of</strong> system facilitates improved<br />

patient care and sharing information among all health<br />

care providers.<br />

Selected Faculty<br />

Awards <strong>2010</strong><br />

Madison Magazine Top Doctors<br />

Gregg A. Heatley, MD<br />

American Academy <strong>of</strong> Ophthalmology<br />

Life Achievement Honor Award<br />

Daniel M. Albert, MD, MS<br />

UW School <strong>of</strong> Medicine and Public<br />

Health Dean’s Award for Association<br />

<strong>of</strong> American Medical Colleges Early<br />

Career Women Faculty Seminar in<br />

Washington, D.C.<br />

Heather A.D. Potter, MD<br />

Yasmin S. Bradfield, MD<br />

Retina Research Foundation/Kathryn<br />

and Latimer Murfee Chair<br />

David M. Gamm, MD, PhD<br />

Foundation Fighting Blindness Board<br />

<strong>of</strong> Directors Award for Retinal<br />

Degenerative Disease Research<br />

David M. Gamm, MD, PhD<br />

<strong>2010</strong> ANNUAL REPORT<br />




Collaboration is key<br />

Aparna Lakkaraju, PhD, and her Assistant Scientist, Jin Xu, MD, MS, view images <strong>of</strong> a cell using the<br />

spinning disk confocal microscope Dr. Lakkaraju is testing for her lab.<br />

Shelves are slowly filling<br />

in Aparna Lakkaraju’s<br />

laboratory in the Medical<br />

Sciences Building on the<br />

<strong>University</strong> <strong>of</strong> <strong>Wisconsin</strong> campus.<br />

As the newest researcher in the<br />

<strong>Department</strong> <strong>of</strong> Ophthalmology<br />

and Visual Sciences, Dr. Lakkaraju<br />

is just settling into her space, and<br />

work is already progressing.<br />

Dr. Lakkaraju joined the<br />

<strong>Department</strong> in June <strong>2010</strong> from<br />

Cornell <strong>University</strong> where she<br />

was a post-doctoral researcher.<br />

She earned her doctorate at the<br />

<strong>University</strong> <strong>of</strong> Minnesota.<br />

The <strong>Department</strong> at the <strong>University</strong><br />

<strong>of</strong> <strong>Wisconsin</strong> <strong>of</strong>fers the opportunity<br />

to build a lab, but more important<br />

to Dr. Lakkaraju, it <strong>of</strong>fers colleagues<br />

with whom to collaborate on<br />

research to understand and<br />

eliminate blinding diseases.<br />

“This is a top-ranked department,”<br />

she said. “There are a lot <strong>of</strong><br />

people to collaborate with in the<br />

<strong>Department</strong> and across campus.”<br />

This includes researchers within<br />

the <strong>Department</strong> <strong>of</strong> Ophthalmology<br />

and Visual Sciences, such as<br />

Nader Sheibani, PhD, who<br />

studies some <strong>of</strong> the same cells<br />

as Dr. Lakkaraju in the context<br />

<strong>of</strong> diseases such as diabetic<br />

retinopathy. She also collaborates<br />

with Robert Nickells, PhD,<br />

vice chair for Research in the<br />

<strong>Department</strong>, Curtis Brandt, PhD,<br />

a virologist who moved part <strong>of</strong><br />

his laboratory to be next to her<br />

laboratory space, and David<br />

Gamm, MD, PhD, a researcher<br />

who studies stem cells in<br />

retinal diseases.<br />

She received a career development<br />

award from Research to Prevent<br />

Blindness, which provides her<br />

with four years <strong>of</strong> funding as<br />

she builds her research program<br />

here. The <strong>Department</strong>, which has<br />

an unrestricted grant from RPB,<br />

nominated her for the award. Dr.<br />

Lakkaraju credits the reputation<br />

<strong>of</strong> the department and the strong<br />

support <strong>of</strong> the Chair, Paul Kaufman,<br />

MD, for her success in getting the<br />

award. Dr. Lakkaraju also received<br />

a vision research grant from the<br />

Karl Kirchgessner Foundation<br />

shortly after arriving at the<br />

<strong>University</strong> <strong>of</strong> <strong>Wisconsin</strong>.<br />

6<br />


Retina diseases focus <strong>of</strong> research<br />

Age-related macular degeneration (AMD)<br />

is the most common cause <strong>of</strong> vision loss in<br />

the elderly in developed countries. Because<br />

retinal degenerative disease, such as macular<br />

degeneration, is a growing area <strong>of</strong> research<br />

nationally, the <strong>Department</strong> <strong>of</strong> Ophthalmology<br />

and Visual Sciences recently remodeled the<br />

space Dr. Lakkaraju now occupies to attract<br />

such a researcher.<br />

“It has been part <strong>of</strong> our strategic plan to<br />

expand our basic science studies in retinal<br />

diseases,” said Dr. Nickells. “We are very<br />

excited to have Dr. Lakkaraju join us as part<br />

<strong>of</strong> our mission to expand in this area.”<br />

As a cell biologist, Dr. Lakkaraju seeks to<br />

understand what happens in AMD at the<br />

cellular level. She is particularly interested in<br />

the retinal pigment epithelium (RPE), a thin<br />

layer <strong>of</strong> cells making up the outermost layer<br />

<strong>of</strong> the retina. “These cells perform many<br />

functions that are necessary for vision,”<br />

she explained. “They are also the site <strong>of</strong> the<br />

initial insult in AMD and other inherited and<br />

acquired retinal degenerations. Each RPE cell<br />

is responsible for 30 to 40 photoreceptors,<br />

so when the RPE dies <strong>of</strong>f, it takes with it<br />

photoreceptors needed for vision. The RPE is<br />

truly indispensable for vision.“<br />

Understanding disease processes at the<br />

level <strong>of</strong> the cell is important to developing<br />

prevention strategies and cures for blinding<br />

disease, she continued. A major hurdle to<br />

developing effective therapies for AMD is<br />

that it is not a simple disease, but one that<br />

has many genetic and environmental causes.<br />

So teasing out exactly what happens in the<br />

disease has been an enormous challenge.<br />

Aparna Lakkaraju , PhD, prepares cells for imaging in her laboratory. Dr. Lakkaraju’s lab studies retinal pigment epithelial cells<br />

which they isolate from human and animal eyes.<br />

<strong>2010</strong> ANNUAL REPORT<br />


RESEARCH continued<br />

“People typically look at the whole<br />

organism,” she said. “But mice, for<br />

example, are nocturnal animals<br />

that do not have a macula, the part<br />

<strong>of</strong> the retina that is responsible for<br />

fine, high-resolution vision found<br />

in humans. In AMD, damage to the<br />

macula makes people lose central<br />

vision. Studying this disease solely<br />

in mice will only provide limited<br />

insight into what leads to blindness<br />

in humans.”<br />

“We are passionate<br />

about conducting<br />

translational research,<br />

and we look forward<br />

to the day when<br />

breakthrough discoveries<br />

made in the lab can be<br />

taken to the clinic to<br />

benefit patients.”<br />

Aparna Lakkaraju, PhD<br />

Dr. Lakkaraju is able to study this<br />

disease because she can use RPE<br />

cells from humans, both those with<br />

and without macular degeneration.<br />

“She can look at them and see how<br />

they are different in a person with<br />

the disease,” Dr. Nickells said.<br />

So far, her research has<br />

demonstrated that A2E, a byproduct<br />

<strong>of</strong> the visual cycle that<br />

accumulates with age in the RPE,<br />

traps cholesterol within these<br />

cells. Because cholesterol is an<br />

important risk factor in other agerelated<br />

diseases like Alzheimer’s<br />

disease, Parkinson’s disease and<br />

heart disease, she is seeking to<br />

understand how cholesterol is<br />

handled in the RPE and retina.<br />

Dr. Lakkaraju also is studying<br />

apolipoprotein E, a protein that<br />

transports cholesterol within<br />

cells and between different<br />

tissues. It occurs in three forms.<br />

One variation is thought to be a<br />

predictor for Alzheimer’s disease,<br />

but may <strong>of</strong>fer protection for<br />

AMD. Dr. Lakkaraju hopes that<br />

her work in RPE cells will help us<br />

understand how this protein can<br />

be a risk factor for one age-related<br />

disease, but protect from another.<br />

Apolipoprotein E also dictates how<br />

cells respond to statins, one <strong>of</strong> the<br />

most commonly used medicines in<br />

the world to treat atherosclerosis<br />

(hardening <strong>of</strong> the arteries). Statins<br />

may be beneficial in AMD, but<br />

studies on the link between statin<br />

use and AMD in humans have been<br />

inconclusive. Understanding how<br />

RPE cells respond to statins will go<br />

a long way toward resolving this.<br />

Apart from high-speed, high-resolution microscopy, the Lakkaraju lab also uses<br />

standard biochemical and molecular biology techniques to analyze proteins and lipids<br />

from healthy and diseased RPE cells.<br />

A second area <strong>of</strong> her research<br />

is aimed at understanding how<br />

lysosomes, which function as the<br />

cell’s garbage disposal system, are<br />

altered with age and cellular stress.<br />

This is especially important for the<br />

RPE because every morning, these<br />

cells are fed a huge breakfast <strong>of</strong><br />

“used up” parts <strong>of</strong> photoreceptors.<br />

This is like eating 100 bagels for<br />

breakfast every day. Because RPE<br />

cells do not regenerate like cells on<br />

our skin or cells that line the gut,<br />

the RPE garbage disposal system<br />

becomes less efficient as we grow<br />

older. One hallmark <strong>of</strong> AMD is the<br />

accumulation <strong>of</strong> undigested fats<br />

and proteins within these cells over<br />

time, leading to a virtual “garbage<br />

catastrophe.” Dr. Lakkaraju uses<br />

high-speed microscopy to see how<br />

the cell’s garbage disposal system<br />

works in health and disease.<br />

8<br />


Having the right tool<br />

Dr. Lakkaraju’s exacting research <strong>of</strong>ten<br />

requires special tools. She has used<br />

spinning disk confocal microscopy to peer<br />

into living RPE cells as they go about their<br />

functions. Although her laboratory does<br />

not yet own this specialized instrument,<br />

she has been able to test one while she<br />

decides among the appropriate machines<br />

and secures funding for it. Conventional<br />

confocal microscopes use high levels <strong>of</strong><br />

light to illuminate the entire sample from a<br />

single pinhole, causing phototoxicity during<br />

live imaging. A spinning disk microscope<br />

has a disk with an array <strong>of</strong> pinholes that<br />

spins very fast and illuminates the sample<br />

at very low levels <strong>of</strong> light. The multiple<br />

pinholes are critical for high-speed<br />

imaging, allowing Dr. Lakkaraju to visualize<br />

changes in living cells that occur on<br />

timescales <strong>of</strong> milliseconds.<br />

Seeing what is happening to a cell under<br />

stress and under normal conditions will<br />

help Dr. Lakkaraju understand what effect<br />

stress and inflammation have on cell<br />

health. This is a first step to translating her<br />

research to patient care.<br />

“We are passionate about conducting<br />

translational research,” she said. “And<br />

we look forward to the day when<br />

breakthrough discoveries made in the<br />

lab can be taken to the clinic to benefit<br />

patients.”<br />

Aparna Lakkaraju plans experiments with Jin Xu.<br />

<strong>2010</strong> ANNUAL REPORT<br />



Strong connections between doctors AND patients<br />

ties in with outstanding care<br />

Georgette Bathum and her daughter, Mary Elizabeth Bathum, enter the UW Health <strong>University</strong> Station Eye<br />

Clinic for an appointment.<br />

One reason many<br />

ophthalmologists are<br />

drawn to their specialty<br />

is the opportunity to form<br />

long-lasting relationships<br />

with their patients while also<br />

having a hands-on surgical<br />

practice. Many physicians like<br />

performing procedures, and<br />

ophthalmologists are<br />

no different.<br />

But it is seeing their patients<br />

come back, year after year,<br />

that keeps many doctors<br />

engaged in their practices.<br />

<strong>University</strong> <strong>of</strong> <strong>Wisconsin</strong><br />

<strong>Department</strong> <strong>of</strong> Ophthalmology<br />

and Visual Sciences<br />

ophthalmologist Barbara Blodi,<br />

MD, is no exception.<br />

Like other retina specialists,<br />

Dr. Blodi <strong>of</strong>ten needs to<br />

follow up with her patients<br />

frequently. Those who receive<br />

injections <strong>of</strong> Avastin or<br />

Lucentis for wet age-related<br />

macular degeneration (AMD)<br />

are in her <strong>of</strong>fice once a month<br />

or so. “I really get to know<br />

these people,” she said. “It’s<br />

almost like internal medicine<br />

or family medicine, where<br />

I learn so much about my<br />

patients and their families,<br />

and they know about mine.”<br />

There are seven retina<br />

specialists in the department<br />

who perform these injections<br />

and all have the same<br />

experience <strong>of</strong> forming close<br />

ties to their patients.<br />

“It’s almost like<br />

internal medicine<br />

or family medicine,<br />

where I learn so<br />

much about my<br />

patients and their<br />

families, and they<br />

know about mine.”<br />

Barbara Blodi, MD<br />

Georgette Bathum, <strong>of</strong><br />

Madison, has been seeing<br />

Dr. Blodi since 2007. “I<br />

was referred to her by an<br />

ophthalmologist in Dubuque,<br />

Iowa, Gretchen Fuerste,<br />

MD, because I had macular<br />

degeneration,” Bathum said.<br />

“From the beginning, I felt Dr.<br />

Blodi had the expertise to take<br />

care <strong>of</strong> my eyes.”<br />

10<br />


Bathum is a retired nurse and knows<br />

medical expertise. In addition to<br />

competence, Bathum likes Dr.<br />

Blodi’s caring. “She is kind,” Bathum<br />

said. “She’s gentle, but you know<br />

what’s happening. She’s direct. I<br />

feel very comfortable in her hands<br />

and I have from the beginning.<br />

What she recommends, I do.”<br />

It’s that trust in Dr. Blodi’s<br />

capabilities as well as her<br />

personality that led Bathum to<br />

agree to participate in a clinical<br />

trial, the Age-Related Eye<br />

Disease Study 2 (AREDS2) for<br />

macular degeneration. AREDS2<br />

is comparing the progression <strong>of</strong><br />

macular degeneration in patients<br />

who receive supplements <strong>of</strong><br />

lutein or fish oil (or both) with<br />

patients who do not receive any<br />

supplements, Dr. Blodi explained.<br />

All patients in the AREDS2 study<br />

are receiving the standard formula<br />

<strong>of</strong> eye vitamins developed as a<br />

result <strong>of</strong> the original AREDS trial.<br />

Although she has convinced herself<br />

that she was randomly assigned to<br />

the group that is receiving placebo<br />

and not receiving a supplement,<br />

Bathum still believes in clinical<br />

trials. “It is helping learn what care<br />

is best,” she said.<br />

Georgette Bathum checks in for her eye clinic appointment with medical receptionist Julie Grim.<br />

<strong>2010</strong> ANNUAL REPORT<br />


PATIENT CARE continued<br />

Dr. Blodi notes that a clinical trial<br />

comparing one treatment with another<br />

under careful monitoring is the best way<br />

to demonstrate which <strong>of</strong> the treatments<br />

is best. This careful monitoring includes<br />

photographs or optical coherence<br />

tomography <strong>of</strong> the affected eyes at each<br />

visit. This allows researchers to understand<br />

how the medications being studied are<br />

working at every point in time, not just at<br />

the beginning and end <strong>of</strong> the study. The<br />

technician prepares the patient for an<br />

injection, if one is needed. This includes<br />

numbing the eye, using a sterile prep and<br />

getting the medication. Medications are<br />

prepared by the UW Health pharmacist in<br />

the building. “This is a real team effort,”<br />

Dr. Blodi said.<br />

Bathum had been losing her vision rapidly<br />

soon after she began seeing Dr. Blodi.<br />

She developed the wet form <strong>of</strong> macular<br />

degeneration and began receiving<br />

injections <strong>of</strong> Lucentis into her eye. The<br />

injections were proven in earlier studies<br />

to improve vision and delay blindness in<br />

people with the onset <strong>of</strong> wet AMD.<br />

As a result <strong>of</strong> the injections, Georgette<br />

has been able to keep up with her active<br />

lifestyle. She and her daughter, Mary<br />

Elizabeth Bathum, own a condominium in a<br />

co-housing complex in Madison. Georgette<br />

is able to go to exercise class, take classes<br />

at the <strong>University</strong> <strong>of</strong> <strong>Wisconsin</strong> and attend<br />

courses in the UW Arboretum, as well as<br />

volunteer at a local nursing home.<br />

Barbara Blodi, MD, chats with her patient, Georgette Bathum, and Georgette’s daughter Mary Elizabeth Bathum. Mary Elizabeth<br />

accompanies her mother to most eye clinic appointments.<br />

12<br />


“This treatment has allowed me to<br />

continue doing the things I enjoy,”<br />

Georgette said.<br />

Mary Elizabeth, who is able to drive<br />

her mom to most appointments –<br />

driving immediately after an injection<br />

is not recommended – said that<br />

having the injections as an option for<br />

her mother was a great relief. “It felt<br />

good to have some hope,” she said.<br />

“This treatment has<br />

allowed me to continue<br />

doing the things I enjoy.”<br />

Georgette Bathum<br />

Georgette agreed. “Any hope was<br />

wonderful,” she said. “I still feel<br />

that way.”<br />

Although the AREDS2 study will be<br />

completed in about a year, Georgette<br />

will request to remain Dr. Blodi’s<br />

patient from now on. And Dr. Blodi is<br />

looking forward to knowing Georgette<br />

and Mary Elizabeth even better.<br />

Barbara Blodi, MD, examines Georgette Bathum’s eyes during a check-up visit. Georgette’s daughter, Mary Elizabeth Bathum,<br />

looks on.<br />

<strong>2010</strong> ANNUAL REPORT<br />




A Day in the Life<br />

Timothy Daley, MD, listens during a Grand Rounds lecture. The talks are held weekly and help keep<br />

residents, faculty and others abreast <strong>of</strong> the latest news in ophthalmology.<br />

When Timothy Daley, MD,<br />

stepped <strong>of</strong>f the elevator<br />

to greet his first patient<br />

<strong>of</strong> the day, he had already been<br />

working for more than two hours.<br />

As chief resident in the <strong>Department</strong><br />

<strong>of</strong> Ophthalmology and Visual<br />

Sciences, Dr. Daley not only attends<br />

the same lectures and education<br />

programs as his colleagues, he<br />

<strong>of</strong>ten is involved in planning and<br />

organizing them as well.<br />

On Fridays, the nine residents<br />

in the <strong>University</strong> <strong>of</strong> <strong>Wisconsin</strong><br />

School <strong>of</strong> Medicine and Public<br />

Health ophthalmology residency<br />

start their day at 7 a.m. with<br />

Retina Workout. Each week a UW<br />

<strong>Department</strong> <strong>of</strong> Ophthalmology and<br />

Visual Sciences retina specialist<br />

goes over cases <strong>of</strong> interest and the<br />

group discusses the issues and<br />

treatment options.<br />

Following Retina Workout, the<br />

entire group <strong>of</strong> residents moves<br />

across the hall to Grand Rounds.<br />

Organized by each year’s chief<br />

resident, Grand Rounds is a<br />

Continuing Medical Educationapproved<br />

lecture series that<br />

features physicians and researchers<br />

from within the <strong>Department</strong>, others<br />

within the UW System and outside<br />

visiting pr<strong>of</strong>essors. The topics<br />

range from basic science talks, to<br />

interesting patient cases, to issues<br />

that affect the practice <strong>of</strong> medicine<br />

in general (such as patient<br />

safety), and to new practices and<br />

procedures in ophthalmology.<br />

When Grand Rounds ended at<br />

8:30 a.m. on a recent Friday, Dr.<br />

Daley hurried to the William S.<br />

Middleton Memorial Veterans<br />

Affairs Hospital, connected to the<br />

UW Hospital and Clinics, to see his<br />

first patients <strong>of</strong> the day. Dr. Daley<br />

spotted Claire Clark immediately,<br />

and led him down the hall to an<br />

exam room.<br />

“Should we take this eye patch<br />

<strong>of</strong>f?” Dr. Daley asked, as he gently<br />

removed the patch that had<br />

protected Clark’s eye since the prior<br />

day’s cataract surgery.<br />

Clark answered yes, and was<br />

thrilled with his improved vision<br />

after the procedure. “This is<br />

heaven,” Clark said. “I was walking<br />

like I was drunk before.”<br />

Dr. Daley checked Clark’s eye<br />

and explained the eye drops he<br />

would need to use for the next<br />

several weeks.<br />

14<br />


“If you have any questions, call right away,”<br />

Dr. Daley reminded his patient. “In fact, I’m<br />

on call this weekend, so if you call, I’ll be the<br />

person you talk to.”<br />

“We really take pride in the<br />

fact that our patient outcomes<br />

for cataract surgery are better<br />

than the national standard<br />

whether residents are involved<br />

or not.”<br />

Andrew Thliveris, MD, PhD<br />

As the senior resident at the Veterans Affairs<br />

Hospital, Dr. Daley examines patients on<br />

his own. His work includes regular eye clinic<br />

exams, pre-surgery check-ups, surgery and<br />

post-surgery check-ups as well. An attending<br />

physician on staff at the UW <strong>Department</strong> <strong>of</strong><br />

Ophthalmology and Visual Sciences reviews<br />

every chart and sees patients if Dr. Daley<br />

requests. In addition, the attending physician<br />

sees every patient who is scheduled for a<br />

procedure such as laser or surgery.<br />

On this day the attending physician was<br />

Andrew Thliveris, MD, PhD, chief <strong>of</strong> the<br />

Ophthalmology Service at the Veterans<br />

Affairs Hospital. First and second year<br />

residents have their cases followed more<br />

closely. And because an attending physician<br />

looks over every chart, the department can<br />

be sure residents are asking for help when it<br />

is needed.<br />

Timothy Daley, MD, walks with his first patient <strong>of</strong> the day, Claire Clark, <strong>of</strong> Lyndon Station. Clark had surgery the day before to<br />

remove a cataract and replace it with an intraocular lens.<br />

<strong>2010</strong> ANNUAL REPORT<br />


EDUCATION continued<br />

For Dr. Thliveris and other faculty at the UW,<br />

teaching residents is only possible if high quality<br />

patient care is maintained. “We really take<br />

pride in the fact that our patient outcomes for<br />

cataract surgery are better than the national<br />

standard whether residents are involved or not,”<br />

Dr. Thliveris said. “A high standard <strong>of</strong> care is the<br />

expectation here.”<br />

Dr. Daley’s next patient is scheduled for surgery<br />

in the next few weeks. Dr. Daley explained all<br />

the risks and the benefits <strong>of</strong> a complicated<br />

operation, combining cataract and retinal<br />

surgery. Dr. Daley will perform cataract removal<br />

with implantation <strong>of</strong> a new lens and a faculty<br />

retina specialist will then do the retinal surgery.<br />

Making sure his patient understands exactly<br />

what is involved is an important part <strong>of</strong> Dr.<br />

Daley’s job. He took time to answer every<br />

question and explain steps in detail.<br />

After seeing several more patients, Dr. Daley<br />

prepared for that day’s surgery.<br />

As residents gain more experience, they are<br />

allowed to operate more independently, but<br />

attending staff is always scrubbed in in case<br />

their skills are needed. As a senior resident on<br />

this VA rotation, Dr. Daley also performs surgery<br />

on Friday afternoons, under the watchful eyes <strong>of</strong><br />

Assistant Pr<strong>of</strong>essor Daniel Knoch, MD.<br />

Surgical procedures are carefully orchestrated,<br />

with a nurse anesthetist, a nurse and an<br />

operating room technician, in addition to Dr.<br />

Daley, Dr. Knoch and the patient. The patient<br />

confessed on this Friday before the Green Bay<br />

Packers played their arch-rival Chicago Bears for<br />

the Division Championship that he was pulling<br />

for the Bears.<br />

Timothy Daley, MD, examines the eyes <strong>of</strong> Clarence Dahmen, Waunakee, who is preparing for surgery in the next few weeks.<br />

16<br />


“That’s OK,” Dr. Daley quipped.<br />

“We’ll take good care <strong>of</strong> you<br />

anyway.”<br />

Cataract surgery is very common<br />

and Dr. Daley is experienced.<br />

But even so, Dr. Knoch served as<br />

surgical assistant and continually<br />

<strong>of</strong>fered suggestions and used every<br />

teachable moment to increase Dr.<br />

Daley’s knowledge <strong>of</strong> ophthalmology<br />

and ophthalmic surgery.<br />

After the procedure, residents<br />

and attending physicians can<br />

review video from the operating<br />

room’s microscope. The video<br />

tracks everything from the view<br />

<strong>of</strong> the surgeon, so everyone can<br />

learn from the experience. “Even<br />

when things go well, you can<br />

learn something to refine your<br />

technique,” Dr. Daley said. “We<br />

want better outcomes and we want<br />

to be more efficient.”<br />

Surgery on Friday means patient<br />

visits on Saturday, even if he weren’t<br />

on call. “Surgery is an honor,” Dr.<br />

Daley said. “I will happily come in<br />

and see my patients on Saturdays.”<br />

Dr. Daley, who completed medical<br />

school, internship and now his<br />

residency at the UW, will also obtain<br />

his fellowship training at the UW<br />

<strong>Department</strong> <strong>of</strong> Ophthalmology and<br />

Visual Sciences. He is choosing<br />

to concentrate on pediatric<br />

ophthalmology and adult strabismus<br />

(eye muscle problems).<br />

Dr. Daley chats with Lyne Kuhn, an ophthalmology technician at the Veterans<br />

Affairs Hospital.<br />

But he likes his rotations at the<br />

VA Hospital. “You see a lot <strong>of</strong><br />

interesting patients. It’s very<br />

rewarding. My grandfather was a<br />

World War II veteran,” he said. “A<br />

lot <strong>of</strong> my patients here remind me<br />

<strong>of</strong> him.”<br />

Dr. Daley made his choice for<br />

ophthalmology when he was<br />

covering the emergency room<br />

during medical school. “A young<br />

man came in with a stick in his eye<br />

and I asked if I could follow along.”<br />

Dr. Knoch was the senior resident<br />

on that case and Gary Sterken,<br />

MD, a faculty member in the<br />

<strong>Department</strong>, was the attending<br />

physician. “Other medical staff<br />

members were turning away, but<br />

I was really interested in how they<br />

were going to help him,” Dr. Daley<br />

said. “Dr. Knoch performed a<br />

simple and elegant procedure, with<br />

just a couple <strong>of</strong> stitches. The patient<br />

ended up having a great outcome,<br />

and I was hooked from then on.”<br />

As his years as a resident near<br />

their end, Dr. Daley feels confident<br />

in treating a large variety <strong>of</strong> eye<br />

diseases. “During the interview<br />

process (for residency programs)<br />

you have the chance to see what it’s<br />

like in other places. I’m really glad I<br />

am able to be here at the UW.” UW<br />

faculty and patients like Mr. Clark<br />

are really glad that Dr. Daley is here<br />

at the UW too.<br />

<strong>2010</strong> ANNUAL REPORT<br />


DONORS<br />


Donation Supports Care for Patients with AMD<br />

Chloe Gomez (clockwise from bottom left) her mother, Melissa Gomez, Melissa’s mother,<br />

Barbara Hevrin and Barbara’s mother Donna Fair. Fair’s family made a donation to UW Health<br />

Rockford Eye Clinic in her memory after she passed away in <strong>2010</strong>.<br />

Donna Fair’s<br />

children gathered<br />

recently and<br />

reminisced about<br />

their mom. Fair, who<br />

passed away in June<br />

<strong>2010</strong>, was remembered<br />

for her battle with<br />

lung cancer and for<br />

her generous spirit.<br />

And they recalled her<br />

“Dr. Mom” treatment<br />

<strong>of</strong> her children and<br />

grandchildren, as well<br />

as her ability to be a sounding<br />

board who <strong>of</strong>fered advice<br />

as needed.<br />

Ronald Danis, MD<br />

But she was also remembered<br />

for advocating for herself. And<br />

it wasn’t just her children who<br />

remembered that part <strong>of</strong> Fair.<br />

Ronald Danis, MD, who was her<br />

ophthalmologist at UW Health Eye<br />

Clinic - Rockford, recalled that she<br />

wanted to try Avastin injections<br />

for her age-related macular<br />

degeneration (AMD).<br />

“She had been a patient for a<br />

while,” Dr. Danis recalled. “Her<br />

vision was 20-400 for about a<br />

year.” Fair had given up driving,<br />

had given up reading and had new<br />

challenges when taking care <strong>of</strong><br />

her home.<br />

Her youngest<br />

daughter, Carol<br />

Larson, <strong>of</strong> Loves Park,<br />

Ill., used tape and a<br />

black marker to put<br />

arrows on Fair’s stove<br />

and other appliances<br />

so that Fair could<br />

continue the chores <strong>of</strong><br />

daily life and continue<br />

to live at home. “It was<br />

really hard to watch<br />

her go through that,”<br />

Larson recalled.<br />

So one day Fair showed up for<br />

her appointment with Dr. Danis<br />

with an article about Avastin, a<br />

then-new drug that was helping<br />

people with AMD improve their<br />

vision. News about clinical trials<br />

<strong>of</strong> Avastin had recently been<br />

presented to ophthalmologists,<br />

but Dr. Danis had limited personal<br />

experience with the drug.<br />

“She gave me the newspaper<br />

article and told me she wanted<br />

me to try that,” Dr. Danis said. “I<br />

was hesitant. The drug works best<br />

when used early in this disease<br />

process and we had no indication<br />

that it would restore vision in<br />

someone who had been legally<br />

blind for more than a year. Without<br />

having clinical trial information,<br />

18<br />


I told her I was skeptical it would help her<br />

longstanding poor vision.”<br />

Fair insisted. After all, she believed in advocating<br />

for herself. Following careful consideration, Dr.<br />

Danis started a series <strong>of</strong> monthly injections in<br />

one eye.<br />

A month after the first injection, Fair returned<br />

to the clinic. “When we checked her vision, she<br />

could not see any better, but she felt like she<br />

was seeing more clearly,” Dr. Danis said. “Then<br />

she asked to have injections in both eyes.”<br />

Miraculously, Fair’s vision improved. Within<br />

a few months, her vision improved to 20-<br />

40 and she was able to drive herself to her<br />

appointments. She was able to read again,<br />

something she had always loved and had<br />

missed. She took down the telephone with<br />

oversize numbers and replaced it with a normal<br />

phone. She was able to pull the taped-on labels<br />

<strong>of</strong>f her appliances. She could see.<br />

It was Fair herself who said her restored vision<br />

was a miracle. She was grateful to be able to<br />

enjoy her freedom. So when she was diagnosed<br />

with lung cancer, and her children and friends<br />

prayed for a miracle cure to the cancer, Fair<br />

didn’t push it.<br />

“She said ‘God doesn’t give that many miracles,<br />

and I’ve had mine.’ I still prayed for a miracle,”<br />

Larson said.<br />

“We all did,” added her sister, Barbara Hevrin, <strong>of</strong><br />

Rockford, Ill.<br />

Even when she was fighting the cancer, and sick<br />

from chemotherapy treatments, she saw Dr.<br />

Danis for her Avastin injections.<br />

“She was such a neat lady,” Dr. Danis said. “She<br />

was one <strong>of</strong> the most perseverant folks I’ve met.<br />

Four <strong>of</strong> Donna Fair’s children, (back row) Carol Larson, David Barrie, Barbara Hevrin and Duane Barrie, gathered recently to<br />

remember their mom.<br />

<strong>2010</strong> ANNUAL REPORT<br />


DONORS continued<br />

Even when she was ill, she always<br />

came in for her eye visits. She was<br />

positive and always seemed grateful<br />

for her vision.”<br />

Indeed, she was grateful. Whether<br />

cooking her famous potato salad<br />

and pies or spending time with<br />

her family at the lake, Donna<br />

Fair loved being able to see.<br />

With grandchildren and great<br />

grandchildren to love, it was a<br />

pleasure to her to watch them<br />

grow up.<br />

“We were using<br />

technology and<br />

treatment that has been<br />

developed through the<br />

collaborative efforts <strong>of</strong><br />

thousands <strong>of</strong> people.”<br />

Ronald Danis, MD<br />

Being grateful for her support, it<br />

seemed natural that when Fair<br />

passed away, her family would use<br />

the memorial gifts to help other<br />

people. They selected three charities<br />

to share in the gifts given in their<br />

mother’s memory. In addition to her<br />

church and hospice, both <strong>of</strong> which<br />

provided comfort and support, the<br />

family chose the UW Health Eye<br />

Clinic-Rockford, which gave her<br />

a miracle.<br />

When the family made the donation<br />

to the Eye Clinic, they asked that it<br />

be used to improve care for other<br />

patients with macular degeneration.<br />

It will go to help fund advanced<br />

imaging machines that continue to<br />

help improve treatment <strong>of</strong> people<br />

with AMD.<br />

The family thinks Fair would like the<br />

choices they made. “She would like<br />

knowing this was going to help other<br />

people,” said her son, David Barrie <strong>of</strong><br />

Winnebago, Ill.<br />

David Barrie listens as his sister, Carol Larson, recalls her mother’s wish to instill<br />

self-reliance in her children, while helping others as well.<br />

When their father died, the family<br />

didn’t have the opportunity to use<br />

memorial donations for charity.<br />

But when their stepfather, George<br />

Fair, died, Donna decided to use the<br />

money to support community areas<br />

George believed in. She was an<br />

example to her children, yet again.<br />

When patients or families make<br />

donations, physicians are not always<br />

aware <strong>of</strong> why the gift was given.<br />

Dr. Danis said he was flattered and<br />

honored that Donna thought so<br />

highly <strong>of</strong> her care. “I can’t disagree<br />

with her that this was a miracle.<br />

But I was just the conduit,” he said.<br />

“We were using technology and<br />

treatment that has been developed<br />

through the collaborative efforts <strong>of</strong><br />

thousands <strong>of</strong> people.”<br />

Beyond regaining her sight, Donna<br />

liked going to the Eye Clinic, and<br />

staff there liked her, too. “They<br />

would come around the counter<br />

and hug her,” Hevrin said. “They<br />

were so friendly. We wanted to<br />

make this gift as a thank you for<br />

being so nice to her. Look at what<br />

this meant to her.”<br />

Donna will be remembered for<br />

touching the hearts <strong>of</strong> all who knew<br />

her, and by way <strong>of</strong> her gift, she will<br />

be helping improve vision in people<br />

who have never had the enjoyment<br />

<strong>of</strong> getting to meet her.<br />

20<br />


<strong>2010</strong> Selected Grants<br />

Albert, Daniel<br />

AMA Archives <strong>of</strong> Ophthalmology Journal Editorship<br />


Children’s Oncology Group<br />

Brandt, Curtis<br />

RRH Gene Therapy for Retinal Degenerative Diseases<br />

DHHS, PHS, NIH<br />

Virion Sialic Acid and HSV Ocular Infection<br />

Colley, Nansi<br />

DHHS, PHS, NIH<br />

Molecular Studies <strong>of</strong> Retinal<br />

Degeneration in Drosophila<br />

Cruickshanks, Karen<br />


Epidemiology <strong>of</strong> Age-related Hearing Loss<br />

DHHS, PHS, NIH<br />

Familial and Birth Cohort<br />

Effects on the Aging Senses<br />

Danis, Ronald<br />


Diabetes Prevention Program Outcomes Study<br />


Action to Control Cardiovascular<br />

Risk in Diabetes: ACCORD Study<br />


Treatment Options for Type 2<br />

Diabetes in Adolescents and Youth<br />

DHHS, PHS, NIH<br />

Ocular Complications <strong>of</strong> AIDS:<br />

Photograph Reading Center<br />

DHHS, PHS, NIH<br />

Fundus Photograph Reading Center<br />

to Support a Multi-Center, Randomized<br />

Trial <strong>of</strong> Luetin, Zeaxanthin, and Omega-3<br />

LCPUFAS in Age-Related<br />

Macular Edema (AREDS II)<br />

Kalil, Ronald<br />

DOD, ARMY Does the Treatment <strong>of</strong> Breast Cancer with<br />

Adjuvant Chemotherapy Interfere with<br />

Hippocampal Neurogenesis and with<br />

Hippocampal-Dependent Cognitive Function?<br />

Kaufman, Paul<br />

PFIZER, INC Regulation <strong>of</strong> outflow facility by gene transfer<br />


Extra-Lenticular Aspects <strong>of</strong><br />

Accommodation and Presbyopia<br />

DHHS, PHS, NIH<br />

ARRA Aqueous humor<br />

dynamics studies in vivo and in vitro<br />

Klein, Barbara<br />

RRF Prevalence and Incident Changes<br />

in Retinal Vascular Caliber Associated<br />

with Medication and Supplement Use<br />

Klein, Ronald<br />

ADA American Diabetes Association<br />

- Mentor-Based Doctoral Fellowship<br />

ADA The epidemiology <strong>of</strong> diabetic complications<br />


Los Angeles Latino Eye Study<br />

Klein, Ronald; Klein, Barbara<br />


Multi-Ethnic Study <strong>of</strong> Atherosclerosis (MESA II)<br />

DHHS, PHS, NIH<br />

Epidemiology <strong>of</strong> Age-Related Macular<br />

Degeneration and Other Retinal Diseases<br />

Levin, Leonard<br />

RRH Pharmacological Protection Of<br />

Endothelial Cells For Retinal Vascular Disease<br />

Mares, Julie; Blodi, Barbara; Chappell, Richard;<br />

Engelman, Corinne; Sarto, Gloria<br />

DHHS, PHS, NIH<br />

Diet and Lifestyle Factors Reducing<br />

Risk for Age-Related Eye Disease<br />

McLellan, Gillian<br />

DHHS, PHS, NIH<br />

Structural and functional characterization<br />

<strong>of</strong> a novel model for glaucoma research<br />

Nickells, Robert<br />

DHHS, PHS, NIH<br />

Characterization <strong>of</strong> RGC<br />

death susceptibility alleles<br />

DHHS, PHS, NIH<br />

Molecular mechanism <strong>of</strong><br />

retinal ganglion cell death<br />

Sheibani, Nader<br />

ADA CYP1B1, NF-kB , and Regulation <strong>of</strong> Angiogenesis<br />

DHHS, PHS, NIH<br />

PEDF and Diabetic Retinopathy<br />

DHHS, PHS, NIH<br />

PECAM-1 and Retinopathy <strong>of</strong> Prematurity<br />

Sheibani, Nader; Assadi, Amir; Assadi-Porter, Fariba<br />

DHHS, PHS, NIH<br />

ARRA Integrated Multidisciplinary<br />

Strategies for Detection<br />

<strong>of</strong> Diabetic Retinopathies<br />

Sheibani, Nader; Jefcoate, Colin<br />

DHHS, PHS, NIH<br />

ARRA CYP1B1 and Retinopathy <strong>of</strong> Prematurity<br />

KEY<br />

Federal funding:<br />

NIH = National Institutes <strong>of</strong> Health<br />

Foundation:<br />

ADA = American Diabetes Association<br />

AMA = American Medical Association<br />

JDRF = Juvenile Diabetes Research Foundation<br />

RRF = Retina Research Foundation<br />

<strong>2010</strong> ANNUAL REPORT<br />


clinical & research<br />

faculty & staff <strong>2010</strong><br />

Julia B. Agapov, MD, DO<br />

Assistant Pr<strong>of</strong>essor<br />

Glaucoma, anterior<br />

segment & cataract<br />

surgery<br />

Daniel M. Albert, MD, MS<br />

Frederick Allison Davis and<br />

Lorenz E. Zimmerman<br />

Pr<strong>of</strong>essor & Chair Emeritus<br />

Ocular oncology,<br />

ophthalmic pathology,<br />

comprehensive<br />

ophthalmology<br />

Michael M. Altaweel, MD<br />

Associate Pr<strong>of</strong>essor<br />

Retina, vitreous, macula,<br />

ocular melanoma<br />

Richard E. Appen, MD<br />

Pr<strong>of</strong>essor Emeritus<br />

Neuro-ophthalmology<br />

Yonca O. Arat, MD<br />

Assistant Pr<strong>of</strong>essor<br />

Comprehensive<br />

ophthalmology,<br />

cataract surgery<br />

Neal P. Barney, MD<br />

Associate Pr<strong>of</strong>essor<br />

Cornea & external<br />

disease, cornea &<br />

cataract surgery, uveitis,<br />

ocular immunology<br />

Barbara A. Blodi, MD<br />

Pr<strong>of</strong>essor<br />

Retinal diseases including<br />

macular degeneration<br />

and diabetic retinopathy<br />

Yasmin S. Bradfield, MD<br />

Associate Pr<strong>of</strong>essor<br />

Pediatric ophthalmology<br />

& strabismus, retinopathy<br />

<strong>of</strong> prematurity, pediatric<br />

cataract surgery & intraocular<br />

lens implantation, pediatric<br />

eyelid surgery, pediatric<br />

glaucoma<br />

Curtis R. Brandt, PhD<br />

Pr<strong>of</strong>essor<br />

Virology, cell & molecular<br />

biology, genetic mapping<br />

& recombinant techniques,<br />

gene therapy<br />

Cat N. Burkat, MD<br />

Assistant Pr<strong>of</strong>essor<br />

Ophthalmic<br />

reconstructive<br />

& cosmetic surgery<br />

Suresh R. Chandra, MD<br />

Pr<strong>of</strong>essor<br />

Vitreoretinal disease,<br />

macular disease, ocular<br />

melanoma, trauma,<br />

international<br />

ophthalmology<br />

Nansi Jo Colley, PhD<br />

Pr<strong>of</strong>essor<br />

Molecular/genetic<br />

studies <strong>of</strong> retinal<br />

degeneration in<br />

Drosophila<br />

Eugene D. Cropp, OD<br />

Clinical Optometrist<br />

Optometry<br />

Karen J. Cruickshanks, PhD<br />

Pr<strong>of</strong>essor<br />

Epidemiology <strong>of</strong> agerelated<br />

ocular disorders,<br />

hearing loss, diabetes<br />

Janet Cushing, OD<br />

Clinical Optometrist<br />

Optometry<br />

Ronald P. Danis, MD<br />

Pr<strong>of</strong>essor, Director <strong>of</strong> the<br />

Fundus Photograph<br />

Reading Center<br />

Macular degeneration,<br />

diabetic retinopathy,<br />

retinal vascular diseases<br />

& posterior ocular<br />

inflammatory disorders<br />

Matthew D. Davis, MD<br />

Pr<strong>of</strong>essor Emeritus<br />

Vitreoretinal disease,<br />

diabetic retinopathy,<br />

clinical trials<br />

Richard K. Dortzbach, MD<br />

Pr<strong>of</strong>essor Emeritus<br />

Ophthalmic plastic &<br />

reconstructive surgery,<br />

surgical techniques<br />

Ivy J. Dreizin, MD<br />

Associate Pr<strong>of</strong>essor<br />

Neuro-ophthalmology<br />

Michael J. Feifarek, MD<br />

Instructor<br />

Comprehensive<br />

ophthalmology<br />

Thomas D. France, MD<br />

Pr<strong>of</strong>essor Emeritus<br />

Pediatric ophthalmology<br />

& strabismus, amblyopia,<br />

visual function testing<br />

David M. Gamm, MD, PhD Justin L. Gottlieb, MD<br />

Assistant Pr<strong>of</strong>essor<br />

Associate Pr<strong>of</strong>essor<br />

Pediatric ophthalmology Retina, vitreous, macula<br />

& strabismus, retinopathy<br />

<strong>of</strong> prematurity, pediatric<br />

cataract surgery &<br />

intraocular lens implantation,<br />

pediatric glaucoma<br />

Gregg A. Heatley, MD<br />

Associate Pr<strong>of</strong>essor<br />

Vice-Chair/Clinical<br />

Glaucoma, anterior<br />

segment & cataract<br />

surgery<br />

Michael S. Ip, MD<br />

Associate Pr<strong>of</strong>essor<br />

Vitreoretinal surgery<br />

for diabetic retinopathy<br />

and retinal detachment,<br />

treatment <strong>of</strong> age-related<br />

macular degeneration,<br />

clinical trials research<br />

Celeste K. Jend, OD<br />

Clinical Optometrist<br />

Optometry<br />

Ronald E. Kalil, PhD<br />

Pr<strong>of</strong>essor<br />

Neural cell death &<br />

repair after brain damage<br />

Paul L. Kaufman, MD<br />

Peter A. Duehr Pr<strong>of</strong>essor<br />

& Chair<br />

Glaucoma, aqueous<br />

humor dynamics, anterior<br />

segment physiology &<br />

pharmacology, presbyopia<br />

Barbara E.K. Klein, MD, MPH<br />

Pr<strong>of</strong>essor<br />

Glaucoma, comprehensive<br />

ophthalmology, cataracts,<br />

diabetic retinopathy,<br />

epidemiology, preventive<br />

medicine<br />

Ronald Klein, MD, MPH<br />

Pr<strong>of</strong>essor<br />

Vitreoretinal disease,<br />

diabetic retinopathy,<br />

age-related eye diseases,<br />

epidemiology<br />

22<br />


Daniel W. Knoch, MD<br />

Assistant Pr<strong>of</strong>essor<br />

Comprehensive<br />

ophthalmology,<br />

cataract surgery<br />

Burton J. Kushner, MD<br />

Pr<strong>of</strong>essor<br />

Pediatric ophthalmology<br />

& strabismus, amblyopia,<br />

surgical techniques<br />

Aparna Lakkaraju, PhD<br />

Assistant Pr<strong>of</strong>essor<br />

Retinal cell biology,<br />

pathogenesis <strong>of</strong> retinal<br />

degenerations,<br />

identification <strong>of</strong><br />

therapeutic targets<br />

Leonard A. Levin, MD, PhD<br />

Pr<strong>of</strong>essor<br />

Neuro-ophthalmology,<br />

ganglion cell death<br />

Mark J. Lucarelli, MD<br />

Pr<strong>of</strong>essor<br />

Oculoplastic, cosmetic<br />

facial and orbital surgery<br />

Julie A. Mares, PhD<br />

Pr<strong>of</strong>essor<br />

Epidemiology <strong>of</strong> eye<br />

disease, nutritional<br />

epidemiology<br />

Michele M. Martin, OD<br />

Clinical Optometrist<br />

Optometry<br />

Frank L. Myers, MD<br />

Pr<strong>of</strong>essor<br />

Retina<br />

Sarah M. Nehls, MD<br />

Assistant Pr<strong>of</strong>essor<br />

Vice-Chair/CME & Faculty<br />

Development<br />

Refractive surgery, cornea<br />

& external disease, cornea<br />

& cataract surgery, uveitis<br />

Robert W. Nickells, PhD<br />

Pr<strong>of</strong>essor<br />

Vice-Chair/Research<br />

Molecular biology <strong>of</strong> cell<br />

death in glaucoma &<br />

retinoblastoma<br />

T. Michael Nork, MD, MS<br />

Associate Pr<strong>of</strong>essor<br />

Diseases & surgery <strong>of</strong><br />

the retina & vitreous<br />

Cameron F. Parsa, MD<br />

Associate Pr<strong>of</strong>essor<br />

Pediatric<br />

ophthalmology and<br />

strabismus, neuroophthalmology<br />

Richard W. Patterson, OD<br />

Clinical Optometrist<br />

Optometry<br />

Todd W. Perkins, MD<br />

Pr<strong>of</strong>essor<br />

Glaucoma, normal<br />

tension glaucoma,<br />

implant devices,<br />

cataract surgery<br />

Arthur S. Polans, PhD<br />

Pr<strong>of</strong>essor<br />

Cancer-related<br />

ocular pathologies<br />

Heather A.D. Potter, MD<br />

Assistant Pr<strong>of</strong>essor<br />

Comprehensive<br />

ophthalmology,<br />

ophthalmic pathology,<br />

cataract surgery ,<br />

refractive surgery<br />

Patricia C. Sabb, MD<br />

Assistant Pr<strong>of</strong>essor<br />

Comprehensive<br />

ophthalmology,<br />

cataract surgery,<br />

refractive surgery<br />

Stephen K. Sauer, MD<br />

Assistant Pr<strong>of</strong>essor<br />

Residency Director<br />

Comprehensive<br />

ophthalmology,<br />

cataract surgery<br />

Nader Sheibani, PhD<br />

Associate Pr<strong>of</strong>essor<br />

Diabetic retinopathy,<br />

retinopathy <strong>of</strong><br />

prematurity, animal<br />

models and retinal<br />

vascular cell biology and<br />

signal transduction<br />

Gary W. Sterken, MD<br />

Assistant Pr<strong>of</strong>essor<br />

Comprehensive<br />

ophthalmology,<br />

cataract surgery,<br />

glaucoma<br />

Thomas S. Stevens, MD<br />

Pr<strong>of</strong>essor<br />

Vitreoretinal disease,<br />

macular disease, diabetic<br />

retinopathy, proliferative<br />

vitreoretinopathy<br />

Michael C. Struck, MD John E. Temprano, MD<br />

Associate Pr<strong>of</strong>essor Associate Pr<strong>of</strong>essor<br />

Pediatric ophthalmology Comprehensive<br />

& strabismus, retinopathy ophthalmology,<br />

<strong>of</strong> prematurity, pediatric cataract surgery<br />

cataract surgery &<br />

intraocular lens implantation,<br />

pediatric glaucoma<br />

Andrew T. Thliveris, MD, PhD<br />

Associate Pr<strong>of</strong>essor<br />

Assistant Residency Director<br />

Chief <strong>of</strong> Ophthalmology<br />

William S. Middleton<br />

Memorial Veterans Hospital<br />

Comprehensive ophthalmology,<br />

cataracts, ocular genetics<br />

Norbert F. Toussaint, Jr., MD<br />

Assistant Pr<strong>of</strong>essor<br />

Comprehensive<br />

ophthalmology<br />

James N. Ver Hoeve, PhD<br />

Senior Scientist<br />

Visual electrophysiology<br />

Amy L. Walker, OD<br />

Clinical Optometrist<br />

Optometry<br />

<strong>2010</strong> ANNUAL REPORT<br />


<strong>2010</strong> clinical trials<br />

A Natural History Study <strong>of</strong> Macular<br />

Telangiectasia: The Mactel Study – Mactel<br />

Principal Investigator: Barbara A. Blodi, MD<br />

Study Coordinator: Michelle R. (Shelly) Olson<br />

Synopsis:<br />

This study is a prospective, cross-sectional study <strong>of</strong><br />

participants with a diagnosis <strong>of</strong> macular telangiectasia.<br />

Age-Related Eye Disease Study 2 (AREDS 2)<br />

Principal Investigators: Suresh R. Chandra, MD,<br />

and Barbara A. Blodi, MD<br />

Study Coordinator: Michelle R. (Shelly) Olson<br />

Synopsis:<br />

A multi-center, randomized trial <strong>of</strong> lutein, zeaxanthin,<br />

and omega-3 long-chain polyunsaturated fatty acids<br />

[docosahexaenoic acid (DHA) and eicosapentaenoic acid<br />

(EPA)] in age-related macular degeneration (AMD).<br />

Comparison <strong>of</strong> AMD Treatment Trials<br />

(CATT) Lucentis – Avastin Trial<br />

Principal Investigators: Suresh R. Chandra,<br />

MD and Michael M. Altaweel, MD<br />

Study Coordinators: Kristine A. Dietzman,<br />

Angie M. Wealti, Jennie R. Perry-Raymond<br />

Synopsis:<br />

This study seeks to evaluate the relative efficacy<br />

and safety <strong>of</strong> treatment <strong>of</strong> subfoveal neovascular<br />

AMD with Lucentis on a fixed schedule, Avastin<br />

on a fixed schedule, Lucentis on a variable<br />

schedule, and Avastin on a variable schedule.<br />

CNV Secondary to AMD Treated with Beta<br />

RadiatioN Epiretinal Therapy – NeoVista Inc.<br />

(CABERNET): NV1-114 Randomized, Prospective,<br />

Controlled Study <strong>of</strong> the NeoVista System<br />

for the Treatment <strong>of</strong> Subfoveal Choroidal<br />

Neovascularization Associated with Wet AMD<br />

Principal Investigator: Michael S. Ip, MD<br />

Study Coordinators: Kristine A. Dietzman<br />

and Guy F. Somers, RN<br />

Synopsis:<br />

The objective <strong>of</strong> the CABERNET Trial is to<br />

evaluate the safety and efficacy <strong>of</strong> focal delivery <strong>of</strong><br />

radiation for the treatment <strong>of</strong> subfoveal choroidal<br />

neovascularization (CNV) associated with wet<br />

age-related macular degeneration (AMD).<br />

Diabetic Retinopathy Clinical Research Network (DRCR)<br />

Synopsis:<br />

STUDY I: Intravitreal Ranibizumab or<br />

Triamcinolone Acetonide in Combination with Laser<br />

Photocoagulation for Diabetic Macular Edema<br />

Principal Investigator: Justin L. Gottlieb, MD<br />

Study Coordinator: Kathryn F. Burke<br />

Synopsis:<br />

The purpose <strong>of</strong> the study is to compare: 1) sham<br />

injection plus laser treatment; 2) injection <strong>of</strong> intravitreal<br />

ranibizumab (Lucentis) plus laser treatment; 3)<br />

injection <strong>of</strong> intravitreal ranibizumab plus deferred<br />

(or delayed) laser treatment; or 4) injection <strong>of</strong><br />

intravitreal triamcinolone plus laser treatment. It is a<br />

three-year study with follow-up every four weeks.<br />

Molecular Prognostic Assay for Uveal Melanoma<br />

Principal Investigator: Michael M. Altaweel, MD<br />

Study Coordinator: Guy F. Somers, RN<br />

Synopsis:<br />

This study will investigate the accuracy <strong>of</strong> a molecular<br />

test for predicting metastasis in uveal melanoma<br />

patients. This may lead to better prognostic testing<br />

and prophylactic treatment for high-risk patients.<br />

OPHTEC – Model 311 Artificial Iris Lens for the<br />

Treatment <strong>of</strong> Visual Disturbances Resulting<br />

from Partial or Total Absence <strong>of</strong> the Human Iris:<br />

Continued Access Compassionate Use Study<br />

Principal Investigator: Michael M. Altaweel, MD<br />

Study Coordinators: Kristine A. Dietzman,<br />

Jennie R. Perry-Raymond<br />

Synopsis:<br />

OPHTEC’s Model 311 Artificial Iris Intraocular Lens is a<br />

unique, single-piece lens manufactured from colored,<br />

ultraviolet light absorbing polymethylmethacrylate<br />

(PMMA). The lens is designed for implantation<br />

into an aphakic human eye for the correction <strong>of</strong><br />

visual disturbances resulting from an incomplete<br />

or totally absent iris and the correction <strong>of</strong> the<br />

spherical refractive error as necessary.<br />

Regeneron: A Randomized, Double Masked, Active<br />

Controlled Phase III Study <strong>of</strong> the Efficacy, Safety,<br />

and Tolerability <strong>of</strong> Repeated Doses <strong>of</strong> Intravitreal<br />

VEGF Trap in Subjects with Neovascular Age-<br />

Related Macular Degeneration (VGFT-OD-0605)<br />

Principal Investigator: Michael M. Altaweel, MD<br />

Study Coordinators: Angie M. Wealti,<br />

Kristine A. Dietzman, Jennie R. Perry-Raymond<br />

Synopsis:<br />

The purpose <strong>of</strong> this study is to assess the efficacy<br />

24<br />


<strong>of</strong> intravitreal (ITV) administered VEGF Trap<br />

compared to ranibizumab in a non-inferiority<br />

paradigm in preventing moderate vision loss in<br />

subjects with all subtypes <strong>of</strong> neovascular AMD.<br />

SK MD7110852 EYE DROP STUDY (A Phase 2b<br />

Dose-Ranging Study <strong>of</strong> Pazopanib Eye Drops versus<br />

Ranibizumab Intravitreal Injections for the Treatment<br />

<strong>of</strong> Neovascular Age-Related Macular Degeneration)<br />

Principal Investigator: Michael M. Altaweel, MD<br />

Study Coordinator: Angie R. Wealti<br />

Synopsis:<br />

A multicenter, randomized, parallel-group, doublemasked<br />

eye drops, and active-controlled study. In<br />

addition to 5 investigational daily-dosed pazopanib eye<br />

drop arms, there will be two additional treatment arms.<br />

PEDIG ~ Intermittent Exotropia Study 1. A Randomized<br />

Trial <strong>of</strong> Bilateral Lateral Rectus Recession versus<br />

Unilateral Lateral Rectus Recession with Medial<br />

Rectus Resection for Intermittent Exotropia<br />

Principal Investigator: Yasmin S. Bradfield, MD<br />

Study Coordinator: Barbara H. Soderling,<br />

Guy F. Somers, RN<br />

Synopsis:<br />

To evaluate the effectiveness <strong>of</strong> bilateral lateral<br />

rectus muscle recession versus unilateral lateral<br />

rectus recession with medial rectus resection<br />

procedures for the treatment <strong>of</strong> basic type and pseudo<br />

divergence excess type intermittent exotropia.<br />

Randomization (1:1) to surgical correction <strong>of</strong><br />

IXT with a bilateral lateral rectus recession<br />

(BLRrec) or a unilateral lateral rectus recession<br />

with medial rectus resection (R&R).<br />

Home Vision Monitoring in AREDS2 for Progression<br />

to NeoVascular AMD Using the ForeseeHome Device<br />

Principal Investigator: Suresh R. Chandra, MD<br />

and Barbara A. Blodi, MD<br />

Study Coordinator: Kathryn F. Burke<br />

Synopsis:<br />

The overall objective <strong>of</strong> this two-arm randomized<br />

clinical trial is to determine if home monitoring using the<br />

comprehensive visual field and telemedicine solution based<br />

on the ForeseeHome device in AREDS2 for participants<br />

at high risk <strong>of</strong> progression to neovascular AMD improves<br />

detection <strong>of</strong> progression to choroidal neovascularization<br />

(CNV) when compared with standard care.<br />

ALCON C-10-004. A Phase 3B, Multicenter,<br />

Randomized, Double-Masked, Parallel-Group,<br />

Active-Controlled Study <strong>of</strong> the Safety and<br />

Efficacy <strong>of</strong> Difluprednate Ophthalmic Emulsion,<br />

0.05% 4 times daily and Prednisolone Acetate<br />

Ophthalmic Suspension, 1.0% 4 times daily<br />

for the Treatment <strong>of</strong> Inflammation Following<br />

Cataract Surgery in children 0 to 3 years <strong>of</strong> age<br />

Principal Investigator: Michael C. Struck, MD<br />

Sub-Investigator: Yasmin S. Bradfield, MD<br />

Study Coordinators: Guy F. Somers, RN,<br />

Barbara H. Soderling<br />

Synopsis:<br />

To compare, in a pediatric population 0 to 3 years <strong>of</strong> age,<br />

the safety and efficacy <strong>of</strong> Durezol and Pred Forte for the<br />

treatment <strong>of</strong> inflammation following cataract surgery.<br />

OPHTHOTECH CORP Protocol no: OPH1001. A Phase<br />

2, Randomized, Double-Masked, Controlled Trial to<br />

Establish the Safety and Efficacy <strong>of</strong> Intravitreous<br />

Injections <strong>of</strong> E10030 (Anti-PDGF Pegylated Aptamer)<br />

Given in Combination with Lucentis in Subjects with<br />

Neovascular Age-Related Macular Degeneration<br />

Principal Investigator: Michael S. Ip, MD<br />

Study Coordinator: Barbara H. Soderling<br />

Synopsis:<br />

The objectives <strong>of</strong> this study are to evaluate the<br />

safety and efficacy <strong>of</strong> E10030 intravitreous injection<br />

when administered in combination with Lucentis<br />

against a control <strong>of</strong> Lucentis alone in subjects with<br />

subfoveal choroidal neovascularization secondary<br />

to age-related macular degeneration (AMD).<br />

Evaluation <strong>of</strong> Possible Toxicity <strong>of</strong> Indocyanine<br />

Green Dye in Macular Hole Surgery Using<br />

Multifocal Electroretinogram<br />

Principal Investigator: Michael S. Ip, MD<br />

Student Researcher: Amol Kulkarni, MD<br />

Study Coordinator: Barbara H. Soderling<br />

Synopsis:<br />

The purpose <strong>of</strong> the research is to test the nerve cells<br />

in the retina by MERG to determine if there are any<br />

differences by using conventional (1 mg/ml) versus low<br />

dose (0.5 mg/ml) <strong>of</strong> ICG during macular hole surgery.<br />

Duration: This pilot study will last no longer than<br />

6-months for each subject. Recruitment will likely<br />

be complete within 8 months <strong>of</strong> study start date.<br />

The data analysis will be performed at the end<br />

<strong>of</strong> the study. It is expected that the study will be<br />

completed and the results will be available within<br />

18 months from the time <strong>of</strong> commencement.<br />

Outcome measures:<br />

Primary: Retinal response density as measured by mfERG at<br />

6-month post-operative visit to evaluate for retinal toxicity.<br />

Secondary: Best corrected snellen visual acuity<br />

(BCVA), and optical coherence tomography (OCT)<br />

evidence <strong>of</strong> hole closure in the operated eye.<br />

<strong>2010</strong> ANNUAL REPORT<br />


<strong>2010</strong> publications<br />

Aiello LP, Edwards AR, Beck RW, Bressler NM,<br />

Davis MD, Ferris F, Glassman AR, Ip MS, Miller<br />

KM. Factors associated with improvement and<br />

worsening <strong>of</strong> visual acuity 2 years after focal/<br />

grid photocoagulation for diabetic macular edema.<br />

Ophthalmology. <strong>2010</strong> May;117(5):946-53.<br />

Albert DM, Atzen SL, Morgan P. The practice <strong>of</strong><br />

ophthalmology in rural <strong>Wisconsin</strong> in the mid-19th<br />

century: from the casebooks <strong>of</strong> Francis Paddock,<br />

MD. Arch Ophthalmol. <strong>2010</strong> Jun;128(6):783-8.<br />

Albert DM, Neekhra A, Wang S, Darjatmoko SR,<br />

Sorenson CM, Dubielzig RR, Sheibani N. Development<br />

<strong>of</strong> choroidal neovascularization in rats with advanced<br />

intense cyclic light-induced retinal degeneration.<br />

Arch Ophthalmol. <strong>2010</strong> Feb;128(2):212-22.<br />

Altmann S, Emanuel A, Toomey M, McIntyre K,<br />

Covert J, Dubielzig RR, Leatherberry G, Murphy<br />

CJ, Kodihalli S, Brandt CR. A quantitative rabbit<br />

model <strong>of</strong> vaccinia keratitis. Invest Ophthalmol<br />

Vis Sci. <strong>2010</strong> Sep;51(9):4531-40.<br />

Altmann S, Toomey M, Nesbit B, McIntyre K,<br />

Covert J, Dubielzig RR, Leatherberry G, Adkins<br />

E, Murphy CJ, Brandt CR. Kinetics <strong>of</strong> immune<br />

cell infiltration in vaccinia virus keratitis. Invest<br />

Ophthalmol Vis Sci. <strong>2010</strong> Sep;51(9):4541-8.<br />

Ambrosius WT, Danis RP, G<strong>of</strong>f DC Jr, Greven CM,<br />

Gerstein HC, Cohen RM, Riddle MC, Miller ME, Buse JB,<br />

Bonds DE, Peterson KA, Rosenberg JD, Perdue LH, Esser<br />

BA, Seaquist LA, Felicetta JV, Chew EY; ACCORD Study<br />

Group. Lack <strong>of</strong> association between thiazolidinediones<br />

and macular edema in type 2 diabetes; the ACCORD eye<br />

substudy. Arch Ophthalmol. <strong>2010</strong> Mar;128(3):312-8.<br />

Blodi BA, Domalpally A, Scott IU, Ip MS, Oden NL,<br />

Elledge J, Warren K, Altaweel MM, Kim JE, Van<br />

Veldhuisen PC. Standard Care vs Corticosteroid for<br />

Retinal Vein Occlusion (SCORE) Study system for<br />

evaluation <strong>of</strong> stereoscopic color fundus photographs<br />

and fluorescein angiograms: SCORE Study <strong>Report</strong><br />

9. Arch Ophthalmol. <strong>2010</strong> Sep;128(9):1140-5.<br />

Boosani CS, Nalabothula N, Sheibani N, Sudhakar<br />

A. Inhibitory effects <strong>of</strong> arresten on bFGF-induced<br />

proliferation, migration, and matrix metalloproteinase-2<br />

activation in mouse retinal endothelial cells.<br />

Curr Eye Res. <strong>2010</strong> Jan;35(1):45-55.<br />

Bradfield Y. Vision screening to detect refractive<br />

error. JAMA. <strong>2010</strong> Sep 8; 304(10):1114-5.<br />

Buie LK, Rasmussen CA, Porterfield EC, Ramgolam<br />

VS, Choi VW, Markovic-Plese S, Samulski RJ,<br />

Kaufman PL, Borras T. Self-complementary AAV<br />

virus (scAAV) safe and long-term gene transfer in<br />

the trabecular meshwork <strong>of</strong> living rats and monkeys.<br />

Invest Ophthalmol Vis Sci. <strong>2010</strong> Jan;51(1):236-48.<br />

Bultmann H, Girdaukas G, Kwon GS, Brandt<br />

CR. The virucidal EB peptide protects host cells<br />

from herpes simplex virus type 1 infection in<br />

the presence <strong>of</strong> serum albumin and aggregates<br />

proteins in a detergent-like manner. Antimicrob<br />

Agents Chemother. <strong>2010</strong> Oct;54(10):4275-89.<br />

Candia OA, Kaufman PL. Remembering<br />

Steven M. Podos, MD, 1937-2009. Invest<br />

Ophthalmol Vis Sci. <strong>2010</strong> Mar;51(3):1261-2.<br />

Chen W, Stambolian D, Edwards AO, Branham KE, Othman<br />

M, Jakobsdottir J, Tosakulwong N, Pericak-Vance MA,<br />

Campochiaro PA, Klein ML, Tan PL, Conley YP, Kanda A,<br />

Kopplin L, Li Y, Augustaitis KJ, Karoukis AJ, Scott WK,<br />

Agarwal A, Kovach JL, Schwartz SG, Postel EA, Brooks M,<br />

Baratz KH, Brown WL, Brucker AJ, Orlin A, Brown G, Ho A,<br />

Regillo C, Donoso L, Tian L, Kaderli B, Hadley D, Hagstrom<br />

SA, Peachey NS, Klein R, Klein BE, Gotoh N, Yamashiro<br />

K, Ferris Iii F, Fagerness JA, Reynolds R, Farrer LA, Kim IK,<br />

Miller JW, Corton M, Carracedo A, Sanchez-Salorio M,<br />

Pugh EW, Doheny KF, Brion M, Deangelis MM, Weeks DE,<br />

Zack DJ, Chew EY, Heckenlively JR, Yoshimura N, Iyengar<br />

SK, Francis PJ, Katsanis N, Seddon JM, Haines JL, Gorin<br />

MB, Abecasis GR, Swaroop A. Genetic variants near TIMP3<br />

and high-density lipoprotein-associated loci influence<br />

susceptibility to age-related macular degeneration. Proc<br />

Natl Acad Sci U S A. <strong>2010</strong> Apr 20;107(16):7401-6.<br />

Cheng CY, Lee KE, Duggal P, Moore EL, Wilson AF, Klein<br />

R, Bailey-Wilson JE, Klein BE. Genome-wide linkage<br />

analysis <strong>of</strong> multiple metabolic factors: evidence <strong>of</strong> genetic<br />

heterogeneity. Obesity (Silver Spring) <strong>2010</strong> Jan;18(1):146-52.<br />

Cheng CY, Reich D, Wong TY, Klein R, Klein BE,<br />

Patterson N, Tandon A, Li M, Boerwinkle E, Sharrett<br />

AR, Kao WH. Admixture mapping scans identify a locus<br />

affecting retinal vascular caliber in hypertensive African<br />

Americans: the Atherosclerosis Risk in Communities<br />

(ARIC) study. PLoS Genet. <strong>2010</strong> Apr 15;6(4):e1000908.<br />

Chew EY, Ambrosius WT, Davis MD, Danis RP, Gangaputra<br />

S, Greven CM, Hubbard L, Esser BA, Lovato JF, Perdue<br />

LH, G<strong>of</strong>f DC, Jr., Cushman WC, Ginsberg HN, Elam MB,<br />

Genuth S, Gerstein HC, Schubart U, Fine LJ. Effects <strong>of</strong><br />

medical therapies on retinopathy progression in type 2<br />

diabetes. N Engl J Med. <strong>2010</strong> Jul 15;363(3):233-44.<br />

Chew EY, Kim J, Coleman HR, Aiello LP, Fish G, Ip M,<br />

Haller JA, Figueroa M, Martin D, Callanan D, Avery R,<br />

Hammel K, Thompson D, Ferris FL. Preliminary assessment<br />

<strong>of</strong> celecoxib and microdiode pulse laser treatment <strong>of</strong><br />

diabetic macular edema. Retina. <strong>2010</strong> Mar;30(3):459-67.<br />

Chew EY, Kim J, Sperduto RD, Datiles MB 3rd, Coleman<br />

HR, Thompson DJ, Milton RC, Clayton JA, Hubbard LD,<br />

Danis RP, Ferris FL 3rd. Evaluation <strong>of</strong> the age-related<br />

eye disease study clinical lens grading system AREDS<br />

report No. 31. Ophthalmology. <strong>2010</strong> Nov;117(11):2112-9.<br />

Danis RP, Scott IU, Qin H, Altaweel MM, Bressler<br />

NM, Bressler SB, Browning DJ, Kollman C. Association<br />

<strong>of</strong> fluorescein angiographic features with visual<br />

acuity and with optical coherence tomographic and<br />

stereoscopic color fundus photographic features<br />

<strong>of</strong> diabetic macular edema in a randomized clinical<br />

trial. Retina. <strong>2010</strong> Nov-Dec;30(10):1627-37.<br />

Diabetic Retinopathy Clinical Research Network<br />

Writing Committee, Haller JA, Qin H, Apte RS, Beck<br />

RR, Bressler NM, Browning DJ, Danis RP, Glassman<br />

AR, Googe JM, Kollman C, Lauer AK, Peters MA,<br />

Stockman ME. Vitrectomy outcomes in eyes with<br />

diabetic macular edema and vitreomacular traction.<br />

Ophthalmology. <strong>2010</strong> Jun;117(6):1087-1093.<br />

26<br />


Domalpally A, Danis RP, Myers D, Kruse CN.<br />

Quantitative analysis <strong>of</strong> the Stratus optical coherence<br />

tomography fast macular thickness map reports.<br />

Indian J Opthalmol. <strong>2010</strong> Mar-Apr;58(2):131-6.<br />

Domalpally A, Gangaputra S, Peng Q, Danis RP.<br />

Repeatability <strong>of</strong> retinal thickness measurements<br />

between spectral-domain and time-domain<br />

optical coherence tomography images in<br />

macular disease. Ophthalmic Surg Lasers<br />

Imaging. <strong>2010</strong> Nov-Dec;41 Suppl:S34-41.<br />

Dutta D, Ray S, Home P, Saha B, Wang S, Sheibani N,<br />

Tawfik O, Cheng N, Paul S. Regulation <strong>of</strong><br />

angiogenesis by histone chaperone HIRA-mediated<br />

incorporation <strong>of</strong> lysine 56-acetylated histone<br />

H3.3 at chromatin domains <strong>of</strong> endothelial genes.<br />

J Biol Chem. <strong>2010</strong> Dec 31;285(53):41567-77.<br />

France TD. Charlie Brown, amblyopia, and<br />

me: A (not so short) personal history <strong>of</strong> the<br />

past forty years <strong>of</strong> diagnosing and treating<br />

amblyopia. Am Orthopt J. <strong>2010</strong>;60:73-81.<br />

Fu YP, Hallman DM, Gonzalez VH, Klein BE, Klein R,<br />

Hayes MG, Cox NJ, Bell GI, Hanis CL. Identification<br />

<strong>of</strong> diabetic retinopathy genes through a genome-wide<br />

association study among Mexican-Americans from Starr<br />

County, Texas. J Ophthalmol. <strong>2010</strong>; <strong>2010</strong>. pii:86129<br />

Gamm DM, Meyer JS. Directed differentiation <strong>of</strong><br />

human induced pluripotent stem cells: a retina<br />

perspective. Regen Med. <strong>2010</strong> May; (3):315-7.<br />

Grutzmacher C, Park S, Elmergreen TL, Tang<br />

Y, Scheef EA, Sheibani N, Sorenson CM.<br />

Opposing effects <strong>of</strong> bim and bcl-2 on lung<br />

endothelial cell migration. Am J Physiol Lung<br />

Cell Mol Physiol. <strong>2010</strong> Nov;299(5):L607-20.<br />

Havas DA, Glenberg AM, Gutowski KA, Lucarelli<br />

MJ, Davidson RJ. (<strong>2010</strong>) Cosmetic use <strong>of</strong> botulinum<br />

toxin-a affects processing <strong>of</strong> emotional language.<br />

Psychol Sci. <strong>2010</strong> Jul; 21(7):895-900.<br />

Hwang FS, Neekhra A, Lucarelli MJ, Warner TF,<br />

Snow SN, Albert DM. Sebaceous cell carcinoma <strong>of</strong><br />

the eyelid: a rapidly enlarging lesion with massive<br />

xanthogranulomatous inflammation. Ophthal Plast<br />

Reconstr Surg. <strong>2010</strong> May-Jun;26(3):208-10.<br />

Ikram MK, Xueling S, Jensen RA, Cotch MF, Hewitt AW,<br />

Ikram MA, Wang JJ, Klein R, Klein BE, Breteler MM,<br />

Cheung N, Liew G, Mitchell P, Uitterlinden AG, Rivadeneira<br />

F, H<strong>of</strong>man A, de Jong PT, van Duijn CM, Kao L, Cheng<br />

CY, Smith AV, Glazer NL, Lumley T, McKnight B, Psaty<br />

BM, Jonasson F, Eiriksdottir G, Aspelund T, Harris TB,<br />

Launer LJ, Taylor KD, Li X, Iyengar SK, Xi Q, Sivakumaran<br />

TA, Mackey DA, Macgregor S, Martin NG, Young TL, Bis<br />

JC, Wiggins KL, Heckbert SR, Hammond CJ, Andrew T,<br />

Fahy S, Attia J, Holliday EG, Scott RJ, Islam FM, Rotter JI,<br />

McAuley AK, Boerwinkle E, Tai ES, Gudnason V, Siscovick<br />

DS, Vingerling JR, Wong TY. Four novel Loci (19q13,<br />

6q24, 12q24, and 5q14) influence the microcirculation<br />

in vivo. PLoS Genet. <strong>2010</strong> Oct 28;6(10):e1001184.<br />

Ip MS. What do I do when I see a patient with a branch<br />

retinal vein occlusion and what are the treatment<br />

options? In: Fekrat S, ed, Curbside Consultation in<br />

Retina. Slack Inc, Thor<strong>of</strong>are, NJ, pp.131-134, <strong>2010</strong>.<br />

Jensen K, Lee KE, Knudtson MD, Klein R, Klein<br />

BE. Stability <strong>of</strong> 35-mm scanners as used in<br />

ophthalmologic research. Ophthalmic Surg<br />

Lasers Imaging. <strong>2010</strong> Jan-Feb; 41(1):60-6.<br />

Jensen RA, Shea S, Ranjit N, Diez-Roux A, Wong<br />

TY, Klein R, Klein BE, Cotch MF, Siscovick DS.<br />

Psychosocial risk factors and retinal microvascular<br />

signs: the multi-ethnic study <strong>of</strong> atherosclerosis.<br />

Am J Epidemiol. <strong>2010</strong> Mar 1;171(5):522-31.<br />

Kaufman PL. Suppression and reduction <strong>of</strong> corticosteroidinduced<br />

ocular hypertension by anecortave in sheep.<br />

Arch Ophthalmol. <strong>2010</strong> Mar;128(3):365-6.<br />

Kempen JH, Altaweel MM, Holbrook JT, Jabs DA,<br />

Sugar EA. The multicenter uveitis steroid treatment<br />

trial: rationale, design, and baseline characteristics.<br />

Am J Ophthalmol. <strong>2010</strong> Apr;149(4):550-61 e10.<br />

Kern TS, Du Y, Miller CM, Hatala DA, Levin LA.<br />

Overexpression <strong>of</strong> Bcl-2 in vascular endothelium<br />

inhibits the microvascular lesions <strong>of</strong> diabetic<br />

retinopathy. Am J Pathol. <strong>2010</strong> May;176(5):2550-8.<br />

Klein BE, Lee KE, Danforth LG, Schaich TM,<br />

Cruickshanks KJ, Klein R. Selected sunsensitizing<br />

medications and incident cataract.<br />

Arch Ophthalmol. <strong>2010</strong> Aug;128(8):959-63.<br />

Klein BE, Lee KE, Moss SE, Trentham-Dietz A, Klein R.<br />

Self- and registry-reported cancer in a population-based<br />

longitudinal study. WMJ. <strong>2010</strong> Oct;109(5):261-6.<br />

Klein BE, Meuer SM, Lee KE, Klein R. Retrodots<br />

in the lens in the Beaver Dam Eye Study cohort.<br />

Ophthalmology. <strong>2010</strong> Oct;117(10):1889-93.<br />

Klein BE. Progression <strong>of</strong> retinopathy in persons<br />

with type 2 diabetes: new data, same conclusions?<br />

Pol Arch Med Wewn. <strong>2010</strong> Oct;120(10):413-6.<br />

Klein BE. Reduction in risk <strong>of</strong> progression <strong>of</strong> diabetic<br />

retinopathy. N Engl J Med. <strong>2010</strong> Jul 15;363(3):287-8.<br />

Klein R, Blodi BA, Meuer SM, Myers CE,<br />

Chew EY, Klein BE. The prevalence <strong>of</strong> macular<br />

telangiectasia type 2 in the Beaver Dam eye study.<br />

Am J Ophthalmol. <strong>2010</strong> Jul;150(1):55-62 e2.<br />

Klein R, Cruickshanks KJ, Nash SD, Krantz EM, Javier<br />

Nieto F, Huang GH, Pankow JS, Klein BE. The prevalence<br />

<strong>of</strong> age-related macular degeneration and associated risk<br />

factors. Arch Ophthalmol. <strong>2010</strong> Jun;128(6):750-8.<br />

Klein R, Klein BE. Are individuals with diabetes<br />

seeing better?: a long-term epidemiological<br />

perspective. Diabetes. <strong>2010</strong> Aug;59(8):1853-60.<br />

Klein R, Knudtson MD, Klein BE, Wong TY,<br />

Cotch MF, Barr G. Emphysema, airflow limitation,<br />

and early age-related macular degeneration.<br />

Arch Ophthalmol. <strong>2010</strong> Apr;128(4):472-7.<br />

<strong>2010</strong> ANNUAL REPORT<br />


<strong>2010</strong> publications<br />

Klein R, Knudtson MD, Klein BE, Zinman B,<br />

Gardiner R, Suissa S, Sinaiko AR, Donnelly SM,<br />

Goodyer P, Strand T, Mauer M. The relationship<br />

<strong>of</strong> retinal vessel diameter to changes in diabetic<br />

nephropathy structural variables in patients with type<br />

1 diabetes. Diabtologia. <strong>2010</strong> Aug;53(8):1638-46.<br />

Klein R, Lee KE, Gangnon RE, Klein BE. The 25-year<br />

incidence <strong>of</strong> visual impairment in type 1 diabetes<br />

mellitus: The <strong>Wisconsin</strong> epidemiologic study <strong>of</strong> diabetic<br />

retinopathy. Ophthalmology. <strong>2010</strong> Jan;117(1):63-70.<br />

Klein R, Myers CE, Klein BE, Zinman B, Gardiner<br />

R, Suissa S, Sinaiko AR, Donnelly SM, Goodyer P,<br />

Strand T, Mauer M. Relationship <strong>of</strong> blood pressure<br />

to retinal vessel diameter in type 1 diabetes mellitus.<br />

Arch Ophthalmol. <strong>2010</strong> Feb;128(2):198-205.<br />

Kopplin LJ, Igo RP, Jr., Wang Y, Sivakumaran TA,<br />

Hagstrom SA, Peachey NS, Francis PJ, Klein ML,<br />

Sangiovanni JP, Chew EY, Pauer GJ, Sturgill GM, Joshi<br />

T, Tian L, Xi Q, Henning AK, Lee KE, Klein R, Klein BE,<br />

Iyengar SK. Genome-wide association identifies SKIV2L<br />

and MYRIP as protective factors for age-related macular<br />

degeneration. Genes Immun. <strong>2010</strong> Dec; 11(8):609-21.<br />

Krantz EM, Cruickshanks KJ, Klein BE, Klein<br />

R, Huang GH, Nieto FJ. Measuring refraction<br />

in adults in epidemiological studies. Arch<br />

Ophthalmol. <strong>2010</strong> Jan;128(1):88-92.<br />

Kraus A, Groenendyk J, Bedard K, Baldwin<br />

TA, Krause KH, Dubois-Dauphin M, Dyck J,<br />

Rosenbaum EE, Korngut L, Colley NJ, Gosgnach<br />

S, Zochodne D, Todd K, Agellon LB, Michalak M.<br />

Calnexin deficiency leads to dysmyelination. J<br />

Biol Chem. <strong>2010</strong> Jun 11;285(24):18928-38.<br />

Kushner BJ. In memoriam: Arthur L. Rosenbaum, MD<br />

(1940-<strong>2010</strong>). Arch Ophthalmol. <strong>2010</strong> Oct;128(10):1383.<br />

Larsen IV, Brandt CR. A cationic TAT peptide<br />

Inhibits Herpes simplex virus type 1 Infection<br />

<strong>of</strong> human corneal epithelial cells. J Ocul<br />

Pharmacol Ther. <strong>2010</strong> Dec;26(6):541-7.<br />

Lee ES, Gabelt BT, Faralli JA, Peters DM, Brandt<br />

CR, Kaufman PL, Bhattacharya SK. COCH<br />

transgene expression in cultured human trabecular<br />

meshwork cells and its effect on outflow facility in<br />

monkey organ cultured anterior segments. Invest<br />

Ophthalmol Vis Sci. <strong>2010</strong> Apr;51(4):2060-6.<br />

Li HK, Florez-Arango JF, Hubbard LD, Esquivel<br />

A, Danis RP, Krupinski EA. Grading diabetic<br />

retinopathy severity from compressed digital retinal<br />

images compared with uncompressed images and<br />

film. Retina. <strong>2010</strong> Nov-Dec;30(10):1651-61.<br />

Li HK, Hubbard LD, Danis RP, Esquivel A, Florez-<br />

Arango JF, Ferrier NJ, Krupinski EA. Digital<br />

versus film Fundus photography for research<br />

grading <strong>of</strong> diabetic retinopathy severity. Invest.<br />

Ophthalmol Vis Sci. <strong>2010</strong> Nov;51(11):5846-52.<br />

Li HK, Hubbard LD, Danis RP, Esquivel A,<br />

Florez-Arango JF, Krupinski EA. Monoscopic<br />

versus stereoscopic retinal photography for<br />

grading diabetic retinopathy severity. Invest<br />

Ophthalmol Vis Sci. <strong>2010</strong> Jun;51(6):3184-92.<br />

Li HK, Hubbard LD, Danis RP, Florez-Arango JF,<br />

Esquivel A, Krupinski EA. Comparison <strong>of</strong> multiple<br />

stereoscopic and monoscopic digital image formats<br />

to film for diabetic macular edema evaluation. Invest<br />

Ophthalmol Vis Sci. <strong>2010</strong> Dec;51(12):6753-61.<br />

Lichtlen P, Lam TT, Nork TM, Streit T, Urech DM.<br />

Relative contribution <strong>of</strong> VEGF and TNF-alpha in the<br />

cynomolgus laser-induced CNV model: comparing the<br />

efficacy <strong>of</strong> bevacizumab, adalimumab, and ESBA105.<br />

Invest Ophthalmol Vis Sci. <strong>2010</strong> Sep;51(9):4738-45.<br />

Lu B, Wang S, Francis PJ, Li T, Gamm DM, Capowski<br />

EE, Lund RD. Cell transplantation to arrest<br />

early changes in an ush2a animal model. Invest<br />

Ophthalmol Vis Sci. <strong>2010</strong> Apr; 51(4):2269-76.<br />

Lutjen-Drecoll E, Kaufman PL, Wasielewski R, Ting-Li<br />

L, Cr<strong>of</strong>t MA. Morphology and accommodative function<br />

<strong>of</strong> the vitreous zonule in human and monkey eyes.<br />

Invest Ophthalmol Vis Sci. <strong>2010</strong> Mar;51(3):1554-64.<br />

Mares JA, Voland R, Adler R, Tinker L, Millen AE,<br />

Moeller SM, Blodi B, Gehrs KM, Wallace RB, Chappell<br />

RJ, Neuhouser ML, Sarto GE. Healthy diets and the<br />

subsequent prevalence <strong>of</strong> nuclear cataract in women.<br />

Arch Ophthalmol. <strong>2010</strong> Jun;128(6):738-49.<br />

Nema N, Ip MS. Intravitreal triamcinolone for<br />

management <strong>of</strong> idiopathic juxtafoveolar telangiectasis.<br />

Oman J Ophthalmol. <strong>2010</strong> Jan;3(1):38-40.<br />

Nguyen TT, Islam FM, Farouque HM, Klein R,<br />

Klein BE, Cotch MF, Herrington DM, Wong<br />

TY. Retinal vascular caliber and brachial flowmediated<br />

dilation: the Multi-Ethnic Study <strong>of</strong><br />

Atherosclerosis. Stroke. <strong>2010</strong> Jul;41(7):1343-8.<br />

Nickells RW. Variations in the rheostat model <strong>of</strong><br />

apoptosis: what studies <strong>of</strong> retinal ganglion cell<br />

death tell us about the functions <strong>of</strong> the Bcl2 family<br />

proteins. Exp Eye Res. <strong>2010</strong> Jul;91(1):2-8.<br />

Nondahl DM, Cruickshanks KJ, Wiley TL, Klein<br />

BE, Klein R, Chappell R, Tweed TS. The tenyear<br />

incidence <strong>of</strong> tinnitus among older adults.<br />

Int J Audiol. <strong>2010</strong> Aug;49(8):580-5.<br />

Nork TM, Kim CB, Heatley GA, Kaufman PL, Lucarelli<br />

MJ, Levin LA, Ver Hoeve JN. Serial multifocal<br />

electroretinograms during long-term elevation and<br />

reduction <strong>of</strong> intraocular pressure in non-human<br />

primates. Doc Ophthalmol. <strong>2010</strong> Jun;120(3):273-89.<br />

Oden NL, VanVeldhuisen PC, Scott IU, Ip MS; SCORE<br />

Study Investigator Group. SCORE Study <strong>Report</strong> 8:<br />

Closed tests for all pairwise comparisons <strong>of</strong> means.<br />

Drug Information Journal (DIA). <strong>2010</strong>;44:405-20.<br />

Pariseau B, Nehls S, Ogawa GS, Sutton DA, Wickes BL,<br />

Romanelli AM. Beauveria keratitis and biopesticides:<br />

case histories and a random amplification <strong>of</strong> polymorphic<br />

DNA comparison. Cornea <strong>2010</strong> Feb;29(2):152-8.<br />

Park S, Dimaio TA, Scheef EA, Sorenson CM,<br />

Sheibani N. PECAM-1 regulates the proangiogenic<br />

properties <strong>of</strong> endothelial cells through modulation<br />

<strong>of</strong> cell-cell and cell-matrix interactions. Am J Physiol<br />

Cell Physiol. <strong>2010</strong> Dec;299(6):C1468-84.<br />

28<br />


Pelzel HR, Schlamp CL, Nickells RW. Histone<br />

H4 deacetylation plays a critical role in early<br />

gene silencing during neuronal apoptosis.<br />

BMC neurosci. <strong>2010</strong> May 26;11:62.<br />

Puhan MA, Van Natta ML, Palella FJ, Addessi<br />

A, Meinert C. Excess mortality in patients with<br />

AIDS in the era <strong>of</strong> highly active antiretroviral<br />

therapy: temporal changes and risk factors.<br />

Clin Infect Dis. <strong>2010</strong> Oct 15;51(8):947-56.<br />

Recchia FM, Scott IU, Brown GC, Brown MM, Ho<br />

AC, Ip MS. Small-gauge pars plana vitrectomy: a<br />

report by the American Academy <strong>of</strong> Ophthalmology.<br />

Ophthalmology. <strong>2010</strong> Sep;117(9):1851-7.<br />

Sahakyan K, Klein BE, Lee KE, Tsai MY, Klein R.<br />

Inflammatory and endothelial dysfunction markers<br />

and proteinuria in persons with type 1 diabetes<br />

mellitus. Eur J Endocrinol. <strong>2010</strong> Jun;162(6):1101-5.<br />

Sahakyan K, Klein BE, Myers CE, Tsai MY, Klein R.<br />

Novel risk factors in long-term hypertension<br />

incidence in type 1 diabetes mellitus. Am.<br />

Heart J. <strong>2010</strong> Jun;159(6):1074-80.<br />

Schwinn MK, Gonzalez JM, Jr., Gabelt BT,<br />

Sheibani N, Kaufman PL, Peters DM. Heparin<br />

II domain <strong>of</strong> fibronectin mediates contractility<br />

through an alpha4beta1 co-signaling pathway.<br />

Exp Cell Res. <strong>2010</strong> May 15;316(9):1500-12.<br />

Scott CJ, Seidler EA, Levin LA. Cell-autonomous<br />

generation <strong>of</strong> mitochondrial superoxide is a signal<br />

for cell death in differentiated neuronal precursor<br />

cells. Brain Res. <strong>2010</strong> Jan 8;1306:142-8.<br />

Seidler EA, Lieven CJ, Thompson AF, Levin LA.<br />

Effectiveness <strong>of</strong> novel borane-phosphine<br />

complexes in inhibiting cell death depends on<br />

the source <strong>of</strong> superoxide production induced by<br />

blockade <strong>of</strong> mitochondrial electron transport.<br />

ACS Chem Neurosci. <strong>2010</strong> Feb 17;1(2):95-103.<br />

Semaan SJ, Li Y, Nickells RW. A single nucleotide<br />

polymorphism in the Bax gene promoter affects<br />

transcription and influences retinal ganglion cell<br />

death. ASN Neuro. <strong>2010</strong> Mar 31;2(2):e00032.<br />

Semaan SJ, Nickells RW. The apoptotic response in<br />

HCT116BAX-/- cancer cells becomes rapidly saturated<br />

with increasing expression <strong>of</strong> a GFP-BAX fusion<br />

protein. BMC Cancer. <strong>2010</strong> Oct 13;10(1):554.<br />

Shankar A, Lee KE, Klein BE, Muntner P, Brazy PC,<br />

Cruickshanks KJ, Nieto FJ, Danforth LG, Schubert<br />

CR, Tsai MY, Klein R. Estimating glomerular<br />

filtration rate in a population-based study. Vasc<br />

Health Risk Manag. <strong>2010</strong> Aug 9;6:619-27.<br />

Sharma A, Yu C, Leung C, Trane A, Lau M, Utokaparch<br />

S, Shaheen F, Sheibani N, Bernatchez P. A new role<br />

for the muscle repair protein dysferlin in endothelial<br />

cell adhesion and angiogenesis. Arterioscler<br />

Thromb Vasc Biol. <strong>2010</strong> Nov;30(11):2196-204.<br />

Sprague BL, Skinner HG, Trentham-Dietz A,<br />

Lee KE, Klein BE, Klein R. Serum calcium and<br />

breast cancer risk in a prospective cohort study.<br />

Ann Epidemiol. <strong>2010</strong> Jan;20(1):82-5.<br />

Struck MC, Hariharan L, Kushner BJ, Bradfield Y, Hetzel S.<br />

Surgical management <strong>of</strong> clinically significant hypertropia<br />

associated with exotropia. J AAPOS. Jun;14(3):216-20.<br />

Subramanian L, Youssef S, Bhattacharya S, Kenealey J,<br />

Polans AS, van Ginkel PR. Resveratrol: challenges<br />

in translation to the clinic - a critical discussion.<br />

Clin Cancer Res. <strong>2010</strong> Dec 15;16(24):5942-8.<br />

Talahalli R, Zarini S, Sheibani N, Murphy RC, Gubitosi-<br />

Klug RA. Increased synthesis <strong>of</strong> leukotrienes in<br />

the mouse model <strong>of</strong> diabetic retinopathy. Invest<br />

Ophthalmol Vis Sci. <strong>2010</strong> Mar;51(3):1699-708.<br />

Tan JC, Kiland JA, Gonzalez JM, Gabelt BT, Peters<br />

DM, Kaufman PL. Sodium orthovanadate effect<br />

on outflow facility and intraocular pressure in live<br />

monkeys. Exp Eye Res. <strong>2010</strong> Oct;91(4):486-90.<br />

Tang Y, Scheef EA, Gurel Z, Sorenson CM, Jefcoate<br />

CR, Sheibani N. CYP1B1 and endothelial nitric oxide<br />

synthase combine to sustain proangiogenic functions<br />

<strong>of</strong> endothelial cells under hyperoxic stress. Am J<br />

Physiol Cell Physiol. <strong>2010</strong> Mar;298(3):C665-78.<br />

Thompson AF, Levin LA. Neuronal differentiation<br />

by analogs <strong>of</strong> staurosporine. Neurochem<br />

Int. <strong>2010</strong> Mar; 56(4):554-60.<br />

Tian B, Heatley GA, Filla MS, Kaufman PL. Effect <strong>of</strong> h-7<br />

on secondary cataract after phacoemulsification in the live<br />

rabbit eye.J Ocul Pharmacol Ther. <strong>2010</strong> Dec;26(6):533-9.<br />

White NH, Sun W, Cleary PA, Tamborlane WV, Danis RP,<br />

Hainsworth DP, Davis MD. Effect <strong>of</strong> prior intensive<br />

therapy in type 1 diabetes on 10-year progression <strong>of</strong><br />

retinopathy in the DCCT/EDIC: comparison <strong>of</strong> adults<br />

and adolescents. Diabetes <strong>2010</strong> May;59(5):1244-53.<br />

Yan Y, Klein R, Heiss G, Girman CJ, Lange EM, Klein BE,<br />

Rose KM, Boerwinkle E, Pankow JS, Brancati FL,<br />

Ballantyne CM, Kottgen A, North KE. The transcription<br />

factor 7-like 2 (TCF7L2) polymorphism may be<br />

associated with focal arteriolar narrowing in Caucasians<br />

with hypertension or without diabetes: the ARIC<br />

Study. BMC Endocr Disord. <strong>2010</strong> May 17;10: 9.<br />

Yatsuya H, Folsom AR, Wong TY, Klein R, Klein BE,<br />

Sharrett AR. Retinal microvascular abnormalities<br />

and risk <strong>of</strong> lacunar stroke: Atherosclerosis Risk in<br />

Communities Study. Stroke. <strong>2010</strong> Jul;41(7):1349-55.<br />

Zhan W, Cruickshanks KJ, Klein BE, Klein R, Huang<br />

GH, Pankow JS, Gangnon RE, Tweed TS. Generational<br />

differences in the prevalence <strong>of</strong> hearing impairment in<br />

older adults. Am J Epidemiol. <strong>2010</strong> Jan 15;171(2):260-6.<br />

Zhang X, Saaddine JB, Chou CF, Cotch MF, Cheng YJ,<br />

Geiss LS, Gregg EW, Albright AL, Klein BE, Klein R.<br />

Prevalence <strong>of</strong> diabetic retinopathy in the United States,<br />

2005-2008. JAMA. <strong>2010</strong> Aug 11;304(6):649-56.<br />

Zhong W, Cruickshanks KJ, Schubert CR, Nieto FJ,<br />

Huang GH, Klein BE, Klein R. Obesity and depression<br />

symptoms in the Beaver Dam Offspring Study population.<br />

Depress Anxiety. <strong>2010</strong> Sep; 27(9):846-51.<br />

<strong>2010</strong> ANNUAL REPORT<br />


<strong>2010</strong> DONOR HONOR ROLL<br />

$100,000+<br />

Daniel M. and Eleanor Albert<br />

Retina Research Foundation<br />

<strong>University</strong> <strong>of</strong> WI Medical Fdtn<br />

$10,000-99,999<br />

Nancy Chow<br />

Sarah E. Slack Prevention<br />

<strong>of</strong> Blindness<br />

$5,000-9,999<br />

Covance Laboratories<br />

North America<br />

OSOD LLC<br />

$1,000-4,999<br />

James C. Allen<br />

Charles J. Chvala<br />

Matthew D. Davis<br />

David E. Grosz<br />

Wendell A. Harker<br />

Newell D. and Helen Jasperson<br />

Albert V. and Dolores H. Kanner<br />

Irving E. Levy<br />

Jeffrey C. Levy<br />

Ronald L. and Jean L. Lewis<br />

Mark F. Mergen<br />

T. Michael Nork<br />

Mary V. H. Pratt<br />

Wanda L. Rood<br />

Isolde Schwegler<br />

Bryan S. Sires<br />

Casmir Turnquist-Held<br />

Amy L. Walker<br />

Lucille M. Warren<br />

Robert G. and Carol A. Witt<br />

Audrey A. Yahr<br />

$500-999<br />

Robert V. Castrovinci<br />

and Kay E. Rutlin<br />

Michelle E. Chizek<br />

Gregg A. Heatley<br />

Michael J. Long<br />

David P. and Cathrine Mc Cann<br />

Merle L. and Barbara Perkins<br />

Harry and Karen M. Roth<br />

Gregory A. Stainer<br />

Robin S. Wilson<br />

Wittenberg Lions Club<br />


FACULTY MEmbers<br />

<strong>2010</strong> FINANCIAL<br />


Charles J. Anderson, MD<br />

Michele A. Basso, PhD - Affiliate<br />

Donald E. Beresky, MD<br />

Stephen M. Boorstein, MD<br />

Christopher R. Croasdale, MD<br />

George E. Davis, MD<br />

Thomas C. Dow, MD<br />

Richard R. Dubielzig, DVM - Affiliate<br />

Daniel R.B. Fary, MD<br />

Judith E. FitzGerald, MD<br />

Russell S. Gonnering, MD<br />

Anne E. Griep, PhD - Affiliate<br />

Kara H. Harbick, MD<br />

Rachael S. Horn, MD<br />

Jeffrey W. Kalenak, MD<br />

Bradley N. Lemke, MD<br />

Bruce M. Massaro, MD<br />

Peter J. McCanna, MD<br />

Kevin B. Miller, MD<br />

Mansoor M. Movaghar, MD<br />

Christopher J. Murphy, DVM, PhD<br />

- Affiliate<br />

Earl W. Nepple, MD<br />

Bikash Pattnaik, PhD - Affiliate<br />

Donna M. Peters, PhD - Affiliate<br />

John G. Rose, Jr., MD<br />

Harry Roth, MD<br />

Kurt A. Schwiesow, MD<br />

Michael H. Scott, MD<br />

Morton E. Smith, MD<br />

Robert G. Smith, MD<br />

Stephen J. Sramek, MD<br />

Rodney J. Sturm, MD<br />

Michael P. Vrabec, MD<br />

John A. Vukich, MD<br />

Mitchell D. Wolf, MD<br />

Tien Yin Wong, PhD<br />

Peter N. Youssef, MD<br />

1<br />

2<br />

3<br />





FOR R&D<br />


& AWARDS<br />

$ 281,235<br />

$ 1,218,307<br />

$ 14,563,883<br />

4 CLINICAL TRIALS $ 310,990<br />

5 HOSPITAL SUPPORT $ 493,034<br />

6 PRACTICE PLAN $ 23,698,867<br />

7<br />

8<br />


FACULTY SUPPORT $ 1,172,089<br />




$ 7,316,736<br />

<strong>2010</strong> ANNUAL REPORT<br />


This <strong>2010</strong> <strong>Annual</strong> <strong>Report</strong> was produced by the <strong>University</strong> <strong>of</strong> <strong>Wisconsin</strong> <strong>Department</strong> <strong>of</strong> Ophthalmology and<br />

Visual Sciences for referring physicians, doctors, donors, alumni and friends <strong>of</strong> the department.<br />

To have your name removed from the <strong>Annual</strong> <strong>Report</strong> mailing list or to have your address changed, please call:<br />

Amy Zimmerman at (608) 263-1480.<br />

Or send your request to:<br />

UW <strong>Department</strong> <strong>of</strong> Ophthalmology<br />

and Visual Sciences<br />

Attn: Amy Zimmerman<br />

2828 Marshall Court, Suite 106<br />

Madison, WI 53705<br />





2828 Marshall Court, Suite 200<br />

Madison, WI 53705<br />

CHAIR<br />

Paul L. Kaufman, MD<br />

UW <strong>Department</strong> <strong>of</strong> Ophthalmology<br />

and Visual Sciences<br />

2828 Marshall Court, Suite 200<br />

Madison, WI 53705<br />

608-263-6070<br />

608-263-1466 fax<br />

EDITOR<br />

Sarah M. Fuelleman<br />

UW <strong>Department</strong> <strong>of</strong> Ophthalmology<br />

and Visual Sciences<br />

2828 Marshall Court, Suite 200<br />

Madison, WI 53705<br />

608-262-3953<br />

608-262-2212 fax<br />

sfuelleman@ophth.wisc.edu<br />



Barbara A. Blodi, MD<br />

Yasmin S. Bradfield, MD<br />

Michelle E. Chizek, MBA<br />

Paul L. Kaufman, MD<br />

Jill Cohen Kolb, MA<br />

Robert W. Nickells, PhD<br />

Christopher C. Temme<br />


Greenleaf Media<br />


Andy Manis Photo<br />

To contribute to the UW <strong>Department</strong><br />

<strong>of</strong> Ophthalmology and Visual<br />

Sciences, please contact:<br />

Steve Ramig, Jr.<br />

Director <strong>of</strong> Development<br />

<strong>University</strong> <strong>of</strong> <strong>Wisconsin</strong> Foundation<br />

1848 <strong>University</strong> Avenue<br />

P.O. Box 8860<br />

Madison WI 53708-8860<br />

608-265-3527<br />




To create, integrate, transmit and apply<br />

knowledge in ophthalmology and visual sciences.<br />

To provide high-quality comprehensive and tertiary<br />

eye care for the university health center, the<br />

Madison community, and the surrounding region<br />

in an efficient and cost-effective manner; and in<br />

select areas to serve as a resource for the nation.<br />

To facilitate multidisciplinary research and<br />

scientific development by fostering research<br />

collaboration and mutual learning, and to play a<br />

leading role in research, teaching and collaborative<br />

studies related to the visual sciences.<br />

To educate medical students, ophthalmologistsin-training<br />

(residents and fellows), practicing<br />

ophthalmologists, researchers in visual<br />

sciences and related disciplines, nonophthalmology<br />

physicians, non-ophthalmology<br />

health care providers and the public.

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