Annual Report 2010 - University of Wisconsin Department of ...
Annual Report 2010 - University of Wisconsin Department of ...
Annual Report 2010 - University of Wisconsin Department of ...
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<strong>2010</strong><br />
ANNUAL<br />
REPORT<br />
<strong>2010</strong> ANNUAL REPORT<br />
1
TABLE OF CONTENTS<br />
Grants 21<br />
Year in Review<br />
Researcher Expands<br />
Retina Program<br />
Strong Connections<br />
Between Doctors & Patients<br />
A Day in the Life:<br />
Residency Prepares Doctors<br />
2<br />
6<br />
10<br />
14<br />
Clinical & Research Faculty<br />
& Staff 22<br />
Clinical Trials 24<br />
Publications 26<br />
Donor Honor Roll 30<br />
Volunteer & Affiliate<br />
Faculty Members 31<br />
Financial Highlights 31<br />
Donation Supports Care for<br />
Patients with AMD<br />
18
FROM THE CHAIR<br />
Each year in our annual<br />
report we share a few<br />
<strong>of</strong> the many wonderful<br />
stories from the <strong>University</strong><br />
<strong>of</strong> <strong>Wisconsin</strong> <strong>Department</strong> <strong>of</strong><br />
Ophthalmology and Visual<br />
Sciences. This year we<br />
illustrate examples <strong>of</strong> the<br />
interrelationship among the<br />
three facets <strong>of</strong> our mission:<br />
research, clinical care and<br />
education.<br />
Basic science researcher<br />
Aparna Lakkaraju, PhD, is<br />
making great strides as she<br />
seeks to understand macular degeneration<br />
at the cellular level. She has brought great<br />
enthusiasm and new ideas after having<br />
completed her doctorate at the <strong>University</strong><br />
<strong>of</strong> Minnesota and a post-doctoral fellowship<br />
at Cornell <strong>University</strong>. Dr. Lakkaraju is drawn<br />
to academic research because she enjoys<br />
working with collaborators who care for human<br />
patients. It is her goal to translate the research<br />
taking place in her laboratory to breakthroughs<br />
that improve patient care.<br />
Barbara Blodi, MD, is a clinical researcher<br />
who also sees patients with retina problems.<br />
Work like hers will one day translate the<br />
discoveries made in our laboratories directly<br />
to the patients in our clinics. Like many other<br />
physicians, Dr. Blodi is proud to work with the<br />
basic scientists and to teach residents and<br />
fellows who train at the UW.<br />
One <strong>of</strong> those residents is senior<br />
Timothy Daley, MD, who will<br />
continue in the <strong>Department</strong> as a<br />
fellow in pediatric ophthalmology<br />
and adult strabismus. Our<br />
most direct link to the future <strong>of</strong><br />
ophthalmology is educating the<br />
residents, fellows and medical<br />
students who pass through our<br />
doors. We are proud <strong>of</strong> their work.<br />
Equally important to us is the<br />
education <strong>of</strong> our patients,<br />
explaining the basics <strong>of</strong> disease<br />
or the translational research<br />
breakthroughs we are making.<br />
An example <strong>of</strong> this patient education is the<br />
biennial Age-related Macular Degeneration<br />
symposium, where more than 500 people<br />
come to learn about the disease. In addition<br />
to people with macular degeneration and their<br />
caregivers, we have connected with public<br />
<strong>of</strong>ficials who deepen their understanding<br />
<strong>of</strong> this disease. This helps them make and<br />
implement health policy more effectively.<br />
We are grateful, as always, to the donors who<br />
help further the work we do here. The new<br />
horizons and opportunities presented by the<br />
explosion <strong>of</strong> scientific knowledge stand in<br />
stark contrast to the difficulty <strong>of</strong> obtaining the<br />
decreasing federal funding to pursue them. We<br />
are fortunate to play a part in advancing vision<br />
science, and our basic science and clinical<br />
researchers continue to compete effectively<br />
for these grants. However, the generosity <strong>of</strong><br />
our donors has made the crucial difference in<br />
our department staying strong as we move to<br />
the future.<br />
Research, clinical care, and education all<br />
overlap to form a continuum <strong>of</strong> excellence. We<br />
are pleased to share this journey, and these<br />
stories, with you.<br />
Paul L. Kaufman, MD<br />
Peter A. Duehr Pr<strong>of</strong>essor<br />
and <strong>Department</strong> Chair<br />
UW <strong>Department</strong> <strong>of</strong> Ophthalmology<br />
and Visual Sciences<br />
<strong>University</strong> <strong>of</strong> <strong>Wisconsin</strong> School<br />
<strong>of</strong> Medicine and Public Health<br />
<strong>2010</strong> ANNUAL REPORT
YEAR IN REVIEW<br />
New faculty/staff join<br />
<strong>Department</strong><br />
Cameron Parsa, MD, an<br />
ophthalmologist who specializes<br />
in pediatric ophthalmology and<br />
adult strabismus as well as in<br />
neuro-ophthalmology, joined the<br />
<strong>Department</strong> <strong>of</strong> Ophthalmology<br />
and Visual Sciences as associate<br />
pr<strong>of</strong>essor in September <strong>2010</strong>.<br />
“Neuro-ophthalmology is a very<br />
broad subspecialty,” he said.<br />
“While the advent <strong>of</strong> neuroimaging<br />
reduced the scope <strong>of</strong> the<br />
Cameron Parsa, MD<br />
field from one previously essential<br />
in accurately localizing many brain<br />
tumors, it is more focused today on observational studies<br />
<strong>of</strong> the optic disc and nerve fiber layer, visible structures<br />
beyond the resolution <strong>of</strong> the MRI. It requires not only<br />
understanding the ocular manifestations <strong>of</strong> systemic and<br />
various neurological conditions, as is commonly perceived,<br />
but also quite frequently, how to detect the more subtle<br />
variants <strong>of</strong> common ocular conditions such as oil-droplet<br />
cataracts or even dry eye syndrome, which can masquerade<br />
as more ominous entities.”<br />
Often problems manifest as misalignment <strong>of</strong> the eyes,<br />
which ties in with Dr. Parsa’s other subspecialty, pediatric<br />
ophthalmology and adult strabismus.<br />
Cameron Parsa, MD, examines eye movements that would specifically pinpoint a brain anomaly in Ariana Cabrera, who<br />
traveled from Beloit, <strong>Wisconsin</strong>, to see a specialist at UW Health Eye Clinic. Dr. Parsa is both a pediatric ophthalmologist<br />
and a neuro-ophthalmologist.<br />
Dr. Parsa joined the <strong>Department</strong> after spending six<br />
years at The Krieger Children’s Eye Center <strong>of</strong> the Wilmer<br />
Ophthalmological Institute at The Johns Hopkins Hospital in<br />
Baltimore, Maryland, where he previously also worked in The<br />
Johns Hopkins Center for Hereditary Eye Diseases.<br />
2<br />
UW DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES
Selected Faculty<br />
Awards <strong>2010</strong><br />
In addition to his clinical practices, he<br />
conducts clinical and theoretic research<br />
designed to immediately impact the clinical<br />
practice <strong>of</strong> ophthalmology. His recent<br />
publications describe the demonstration <strong>of</strong><br />
an individual’s systemic inherited potential<br />
for angiogenesis via the analysis <strong>of</strong> optic<br />
nerve findings in various syndromes, the<br />
origin <strong>of</strong> port-wine stains, glaucoma and<br />
seizures in the Sturge-Weber syndrome and<br />
related diseases as simply due to venous<br />
dysplasia, and the nature <strong>of</strong> optic gliomas.<br />
His research has recently determined<br />
that this juvenile brain tumor represents<br />
a hamartoma rather than a neoplasm and<br />
that treatments now given for this tumor are<br />
actually ineffective and increase the risk <strong>of</strong><br />
malignant transformation later in life.<br />
Dr. Parsa sees patients at UW Health<br />
<strong>University</strong> Station Eye Clinic in Madison and<br />
Affinity Ophthalmology Offices in Menasha.<br />
Cameron Parsa, MD, looks over images for a patient<br />
with Darla Coullard, an ophthalmologic technician<br />
at UW Health <strong>University</strong> Station Eye Clinic. Having<br />
and keeping old images on file allows for helpful<br />
comparisons during the examination and to assess for<br />
any disease or progression.<br />
Richard Patterson, OD, joined the<br />
<strong>Department</strong> in March <strong>2010</strong>. He had<br />
previously worked in private optometry<br />
practice.<br />
Dr. Patterson brings<br />
experience with<br />
optics to the practice<br />
<strong>of</strong> optometry. “The<br />
science <strong>of</strong> optics<br />
is complex,” Dr.<br />
Patterson said,<br />
“and our patients<br />
consistently wanted<br />
to know more about<br />
their lens correction<br />
in a way they<br />
Richard Patterson, OD<br />
could understand.<br />
I discovered that I<br />
could relate their changes in eyesight in a<br />
non-technical way that helped them get a<br />
better handle on it. To me, that was the spark<br />
that led to my wanting to pursue my doctor<br />
<strong>of</strong> optometry training.<br />
“It was all about developing the relationship<br />
with a patient.”<br />
Dr. Patterson attended Indiana <strong>University</strong> –<br />
Bloomington to earn his doctor <strong>of</strong> optometry<br />
degree. He and his family moved to Madison<br />
in 2001 where he began to serve several<br />
Southern <strong>Wisconsin</strong> communities with his<br />
optical and optometric skills. In addition<br />
to providing clinical care to keep patients’<br />
eyes healthy, Dr. Patterson maintains<br />
his strong interest in optics, and enjoys<br />
being part <strong>of</strong> a full-service medical clinic<br />
delivering comprehensive eye care to the<br />
community and partnering with UW Health<br />
ophthalmologists and opticians.<br />
Best Doctors in America<br />
Gregg A. Heatley, MD<br />
Paul L. Kaufman, MD<br />
Burton J.Kushner, MD<br />
Leonard A. Levin, MD<br />
Castle Connolly Top Doctors<br />
Daniel M. Albert, MD, MS<br />
Paul L . Kaufman, MD<br />
Burton J. Kushner, MD<br />
Todd W. Perkins, MD<br />
Consumer’s Research Council <strong>of</strong><br />
America’s Top Ophthalmologists<br />
Mark J. Lucarelli, MD<br />
Fellow <strong>of</strong> the Association for Research<br />
in Vision and Ophthalmology<br />
Leonard A. Levin, MD (Gold)<br />
Robert W. Nickells, PhD (Silver)<br />
T. Michael Nork, MD, MS (Silver)<br />
<strong>2010</strong> ANNUAL REPORT<br />
3
YEAR IN REVIEW continued<br />
Labs moved for<br />
mentoring<br />
When a new researcher, such as Aparna<br />
Lakkaraju, PhD, joins the <strong>Department</strong> <strong>of</strong><br />
Ophthalmology and Visual Sciences, a formal<br />
mentoring committee is set up to provide<br />
support and advice.<br />
In Dr. Lakkaraju’s<br />
case, one <strong>of</strong> the<br />
researchers on<br />
her mentoring<br />
committee, Curtis<br />
Brandt, PhD, moved<br />
his laboratory<br />
space next to<br />
Dr. Lakkaraju’s<br />
laboratory in the<br />
Medical Sciences<br />
Center (the old<br />
Aparna Lakkaraju, PhD<br />
<strong>University</strong> Hospital)<br />
to facilitate collaboration and a supportive<br />
relationship. It also allows Dr. Brandt and<br />
his staff to have access to state-<strong>of</strong>-the art<br />
technology <strong>of</strong> new laboratory space.<br />
In the past, many new faculty created their<br />
own informal mentoring relationships.<br />
The mentoring committee is established<br />
to provide formal support to new faculty<br />
members. A formal system ensures that new<br />
faculty have a team dedicated to helping<br />
grow research opportunities.<br />
Curtis Brandt, PhD, and Aparna Lakkaraju, PhD, <strong>of</strong>ten discuss research projects during the course <strong>of</strong> their work days.<br />
Collaboration is facilitated by Dr. Brandt moving his labratory into space next to Dr. Lakkaraju’s new laboratory.<br />
4<br />
UW DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES
New Director leads<br />
residency program<br />
Stephen Sauer,<br />
MD, took over<br />
leadership <strong>of</strong> the<br />
<strong>Department</strong>’s<br />
Residency<br />
Program in July<br />
<strong>2010</strong>, when<br />
Yasmin Bradfield,<br />
MD, stepped<br />
down after leading<br />
us to successful<br />
reaccreditation<br />
Stephen Sauer, MD<br />
in 2009. Dr.<br />
Sauer served<br />
as director <strong>of</strong><br />
Core Competencies, a key aspect <strong>of</strong> the<br />
residency program, and brings a wealth <strong>of</strong><br />
education experience to the role. He will<br />
build on a program that is stronger than<br />
ever, expanding and adding rotations and<br />
preparing for international service for our<br />
residents.<br />
Dr. Sauer was awarded the <strong>University</strong> <strong>of</strong><br />
<strong>Wisconsin</strong> Hospitals and Clinics Program<br />
Director Administrative Fellowship<br />
in <strong>2010</strong>.<br />
Electronic<br />
Medical Record<br />
impleMented<br />
The <strong>Department</strong> took its first steps toward<br />
implementing an electronic medical<br />
record (EMR) system in <strong>2010</strong>. Although<br />
groundwork began several years earlier,<br />
in <strong>2010</strong> the first clinicians began using the<br />
Epic-designed system. UW Health has<br />
rolled out this EMR to all departments,<br />
allowing physicians and patients to have<br />
access to medical records throughout the<br />
organization.<br />
Optometrists and comprehensive<br />
ophthalmologists use the medical record<br />
system for documenting patient exams. The<br />
system will be rolled out to subspecialists<br />
in 2012.<br />
An ophthalmology technician enters patient<br />
information into UW Health’s electronic medical<br />
record system. This kind <strong>of</strong> system facilitates improved<br />
patient care and sharing information among all health<br />
care providers.<br />
Selected Faculty<br />
Awards <strong>2010</strong><br />
Madison Magazine Top Doctors<br />
Gregg A. Heatley, MD<br />
American Academy <strong>of</strong> Ophthalmology<br />
Life Achievement Honor Award<br />
Daniel M. Albert, MD, MS<br />
UW School <strong>of</strong> Medicine and Public<br />
Health Dean’s Award for Association<br />
<strong>of</strong> American Medical Colleges Early<br />
Career Women Faculty Seminar in<br />
Washington, D.C.<br />
Heather A.D. Potter, MD<br />
Yasmin S. Bradfield, MD<br />
Retina Research Foundation/Kathryn<br />
and Latimer Murfee Chair<br />
David M. Gamm, MD, PhD<br />
Foundation Fighting Blindness Board<br />
<strong>of</strong> Directors Award for Retinal<br />
Degenerative Disease Research<br />
David M. Gamm, MD, PhD<br />
<strong>2010</strong> ANNUAL REPORT<br />
5
RESEARCH<br />
RESEARCHER EXPANDS RETINA PROGRAM<br />
Collaboration is key<br />
Aparna Lakkaraju, PhD, and her Assistant Scientist, Jin Xu, MD, MS, view images <strong>of</strong> a cell using the<br />
spinning disk confocal microscope Dr. Lakkaraju is testing for her lab.<br />
Shelves are slowly filling<br />
in Aparna Lakkaraju’s<br />
laboratory in the Medical<br />
Sciences Building on the<br />
<strong>University</strong> <strong>of</strong> <strong>Wisconsin</strong> campus.<br />
As the newest researcher in the<br />
<strong>Department</strong> <strong>of</strong> Ophthalmology<br />
and Visual Sciences, Dr. Lakkaraju<br />
is just settling into her space, and<br />
work is already progressing.<br />
Dr. Lakkaraju joined the<br />
<strong>Department</strong> in June <strong>2010</strong> from<br />
Cornell <strong>University</strong> where she<br />
was a post-doctoral researcher.<br />
She earned her doctorate at the<br />
<strong>University</strong> <strong>of</strong> Minnesota.<br />
The <strong>Department</strong> at the <strong>University</strong><br />
<strong>of</strong> <strong>Wisconsin</strong> <strong>of</strong>fers the opportunity<br />
to build a lab, but more important<br />
to Dr. Lakkaraju, it <strong>of</strong>fers colleagues<br />
with whom to collaborate on<br />
research to understand and<br />
eliminate blinding diseases.<br />
“This is a top-ranked department,”<br />
she said. “There are a lot <strong>of</strong><br />
people to collaborate with in the<br />
<strong>Department</strong> and across campus.”<br />
This includes researchers within<br />
the <strong>Department</strong> <strong>of</strong> Ophthalmology<br />
and Visual Sciences, such as<br />
Nader Sheibani, PhD, who<br />
studies some <strong>of</strong> the same cells<br />
as Dr. Lakkaraju in the context<br />
<strong>of</strong> diseases such as diabetic<br />
retinopathy. She also collaborates<br />
with Robert Nickells, PhD,<br />
vice chair for Research in the<br />
<strong>Department</strong>, Curtis Brandt, PhD,<br />
a virologist who moved part <strong>of</strong><br />
his laboratory to be next to her<br />
laboratory space, and David<br />
Gamm, MD, PhD, a researcher<br />
who studies stem cells in<br />
retinal diseases.<br />
She received a career development<br />
award from Research to Prevent<br />
Blindness, which provides her<br />
with four years <strong>of</strong> funding as<br />
she builds her research program<br />
here. The <strong>Department</strong>, which has<br />
an unrestricted grant from RPB,<br />
nominated her for the award. Dr.<br />
Lakkaraju credits the reputation<br />
<strong>of</strong> the department and the strong<br />
support <strong>of</strong> the Chair, Paul Kaufman,<br />
MD, for her success in getting the<br />
award. Dr. Lakkaraju also received<br />
a vision research grant from the<br />
Karl Kirchgessner Foundation<br />
shortly after arriving at the<br />
<strong>University</strong> <strong>of</strong> <strong>Wisconsin</strong>.<br />
6<br />
UW DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES
Retina diseases focus <strong>of</strong> research<br />
Age-related macular degeneration (AMD)<br />
is the most common cause <strong>of</strong> vision loss in<br />
the elderly in developed countries. Because<br />
retinal degenerative disease, such as macular<br />
degeneration, is a growing area <strong>of</strong> research<br />
nationally, the <strong>Department</strong> <strong>of</strong> Ophthalmology<br />
and Visual Sciences recently remodeled the<br />
space Dr. Lakkaraju now occupies to attract<br />
such a researcher.<br />
“It has been part <strong>of</strong> our strategic plan to<br />
expand our basic science studies in retinal<br />
diseases,” said Dr. Nickells. “We are very<br />
excited to have Dr. Lakkaraju join us as part<br />
<strong>of</strong> our mission to expand in this area.”<br />
As a cell biologist, Dr. Lakkaraju seeks to<br />
understand what happens in AMD at the<br />
cellular level. She is particularly interested in<br />
the retinal pigment epithelium (RPE), a thin<br />
layer <strong>of</strong> cells making up the outermost layer<br />
<strong>of</strong> the retina. “These cells perform many<br />
functions that are necessary for vision,”<br />
she explained. “They are also the site <strong>of</strong> the<br />
initial insult in AMD and other inherited and<br />
acquired retinal degenerations. Each RPE cell<br />
is responsible for 30 to 40 photoreceptors,<br />
so when the RPE dies <strong>of</strong>f, it takes with it<br />
photoreceptors needed for vision. The RPE is<br />
truly indispensable for vision.“<br />
Understanding disease processes at the<br />
level <strong>of</strong> the cell is important to developing<br />
prevention strategies and cures for blinding<br />
disease, she continued. A major hurdle to<br />
developing effective therapies for AMD is<br />
that it is not a simple disease, but one that<br />
has many genetic and environmental causes.<br />
So teasing out exactly what happens in the<br />
disease has been an enormous challenge.<br />
Aparna Lakkaraju , PhD, prepares cells for imaging in her laboratory. Dr. Lakkaraju’s lab studies retinal pigment epithelial cells<br />
which they isolate from human and animal eyes.<br />
<strong>2010</strong> ANNUAL REPORT<br />
7
RESEARCH continued<br />
“People typically look at the whole<br />
organism,” she said. “But mice, for<br />
example, are nocturnal animals<br />
that do not have a macula, the part<br />
<strong>of</strong> the retina that is responsible for<br />
fine, high-resolution vision found<br />
in humans. In AMD, damage to the<br />
macula makes people lose central<br />
vision. Studying this disease solely<br />
in mice will only provide limited<br />
insight into what leads to blindness<br />
in humans.”<br />
“We are passionate<br />
about conducting<br />
translational research,<br />
and we look forward<br />
to the day when<br />
breakthrough discoveries<br />
made in the lab can be<br />
taken to the clinic to<br />
benefit patients.”<br />
Aparna Lakkaraju, PhD<br />
Dr. Lakkaraju is able to study this<br />
disease because she can use RPE<br />
cells from humans, both those with<br />
and without macular degeneration.<br />
“She can look at them and see how<br />
they are different in a person with<br />
the disease,” Dr. Nickells said.<br />
So far, her research has<br />
demonstrated that A2E, a byproduct<br />
<strong>of</strong> the visual cycle that<br />
accumulates with age in the RPE,<br />
traps cholesterol within these<br />
cells. Because cholesterol is an<br />
important risk factor in other agerelated<br />
diseases like Alzheimer’s<br />
disease, Parkinson’s disease and<br />
heart disease, she is seeking to<br />
understand how cholesterol is<br />
handled in the RPE and retina.<br />
Dr. Lakkaraju also is studying<br />
apolipoprotein E, a protein that<br />
transports cholesterol within<br />
cells and between different<br />
tissues. It occurs in three forms.<br />
One variation is thought to be a<br />
predictor for Alzheimer’s disease,<br />
but may <strong>of</strong>fer protection for<br />
AMD. Dr. Lakkaraju hopes that<br />
her work in RPE cells will help us<br />
understand how this protein can<br />
be a risk factor for one age-related<br />
disease, but protect from another.<br />
Apolipoprotein E also dictates how<br />
cells respond to statins, one <strong>of</strong> the<br />
most commonly used medicines in<br />
the world to treat atherosclerosis<br />
(hardening <strong>of</strong> the arteries). Statins<br />
may be beneficial in AMD, but<br />
studies on the link between statin<br />
use and AMD in humans have been<br />
inconclusive. Understanding how<br />
RPE cells respond to statins will go<br />
a long way toward resolving this.<br />
Apart from high-speed, high-resolution microscopy, the Lakkaraju lab also uses<br />
standard biochemical and molecular biology techniques to analyze proteins and lipids<br />
from healthy and diseased RPE cells.<br />
A second area <strong>of</strong> her research<br />
is aimed at understanding how<br />
lysosomes, which function as the<br />
cell’s garbage disposal system, are<br />
altered with age and cellular stress.<br />
This is especially important for the<br />
RPE because every morning, these<br />
cells are fed a huge breakfast <strong>of</strong><br />
“used up” parts <strong>of</strong> photoreceptors.<br />
This is like eating 100 bagels for<br />
breakfast every day. Because RPE<br />
cells do not regenerate like cells on<br />
our skin or cells that line the gut,<br />
the RPE garbage disposal system<br />
becomes less efficient as we grow<br />
older. One hallmark <strong>of</strong> AMD is the<br />
accumulation <strong>of</strong> undigested fats<br />
and proteins within these cells over<br />
time, leading to a virtual “garbage<br />
catastrophe.” Dr. Lakkaraju uses<br />
high-speed microscopy to see how<br />
the cell’s garbage disposal system<br />
works in health and disease.<br />
8<br />
UW DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES
Having the right tool<br />
Dr. Lakkaraju’s exacting research <strong>of</strong>ten<br />
requires special tools. She has used<br />
spinning disk confocal microscopy to peer<br />
into living RPE cells as they go about their<br />
functions. Although her laboratory does<br />
not yet own this specialized instrument,<br />
she has been able to test one while she<br />
decides among the appropriate machines<br />
and secures funding for it. Conventional<br />
confocal microscopes use high levels <strong>of</strong><br />
light to illuminate the entire sample from a<br />
single pinhole, causing phototoxicity during<br />
live imaging. A spinning disk microscope<br />
has a disk with an array <strong>of</strong> pinholes that<br />
spins very fast and illuminates the sample<br />
at very low levels <strong>of</strong> light. The multiple<br />
pinholes are critical for high-speed<br />
imaging, allowing Dr. Lakkaraju to visualize<br />
changes in living cells that occur on<br />
timescales <strong>of</strong> milliseconds.<br />
Seeing what is happening to a cell under<br />
stress and under normal conditions will<br />
help Dr. Lakkaraju understand what effect<br />
stress and inflammation have on cell<br />
health. This is a first step to translating her<br />
research to patient care.<br />
“We are passionate about conducting<br />
translational research,” she said. “And<br />
we look forward to the day when<br />
breakthrough discoveries made in the<br />
lab can be taken to the clinic to benefit<br />
patients.”<br />
Aparna Lakkaraju plans experiments with Jin Xu.<br />
<strong>2010</strong> ANNUAL REPORT<br />
9
PATIENT CARE<br />
Strong connections between doctors AND patients<br />
ties in with outstanding care<br />
Georgette Bathum and her daughter, Mary Elizabeth Bathum, enter the UW Health <strong>University</strong> Station Eye<br />
Clinic for an appointment.<br />
One reason many<br />
ophthalmologists are<br />
drawn to their specialty<br />
is the opportunity to form<br />
long-lasting relationships<br />
with their patients while also<br />
having a hands-on surgical<br />
practice. Many physicians like<br />
performing procedures, and<br />
ophthalmologists are<br />
no different.<br />
But it is seeing their patients<br />
come back, year after year,<br />
that keeps many doctors<br />
engaged in their practices.<br />
<strong>University</strong> <strong>of</strong> <strong>Wisconsin</strong><br />
<strong>Department</strong> <strong>of</strong> Ophthalmology<br />
and Visual Sciences<br />
ophthalmologist Barbara Blodi,<br />
MD, is no exception.<br />
Like other retina specialists,<br />
Dr. Blodi <strong>of</strong>ten needs to<br />
follow up with her patients<br />
frequently. Those who receive<br />
injections <strong>of</strong> Avastin or<br />
Lucentis for wet age-related<br />
macular degeneration (AMD)<br />
are in her <strong>of</strong>fice once a month<br />
or so. “I really get to know<br />
these people,” she said. “It’s<br />
almost like internal medicine<br />
or family medicine, where<br />
I learn so much about my<br />
patients and their families,<br />
and they know about mine.”<br />
There are seven retina<br />
specialists in the department<br />
who perform these injections<br />
and all have the same<br />
experience <strong>of</strong> forming close<br />
ties to their patients.<br />
“It’s almost like<br />
internal medicine<br />
or family medicine,<br />
where I learn so<br />
much about my<br />
patients and their<br />
families, and they<br />
know about mine.”<br />
Barbara Blodi, MD<br />
Georgette Bathum, <strong>of</strong><br />
Madison, has been seeing<br />
Dr. Blodi since 2007. “I<br />
was referred to her by an<br />
ophthalmologist in Dubuque,<br />
Iowa, Gretchen Fuerste,<br />
MD, because I had macular<br />
degeneration,” Bathum said.<br />
“From the beginning, I felt Dr.<br />
Blodi had the expertise to take<br />
care <strong>of</strong> my eyes.”<br />
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UW DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES
Bathum is a retired nurse and knows<br />
medical expertise. In addition to<br />
competence, Bathum likes Dr.<br />
Blodi’s caring. “She is kind,” Bathum<br />
said. “She’s gentle, but you know<br />
what’s happening. She’s direct. I<br />
feel very comfortable in her hands<br />
and I have from the beginning.<br />
What she recommends, I do.”<br />
It’s that trust in Dr. Blodi’s<br />
capabilities as well as her<br />
personality that led Bathum to<br />
agree to participate in a clinical<br />
trial, the Age-Related Eye<br />
Disease Study 2 (AREDS2) for<br />
macular degeneration. AREDS2<br />
is comparing the progression <strong>of</strong><br />
macular degeneration in patients<br />
who receive supplements <strong>of</strong><br />
lutein or fish oil (or both) with<br />
patients who do not receive any<br />
supplements, Dr. Blodi explained.<br />
All patients in the AREDS2 study<br />
are receiving the standard formula<br />
<strong>of</strong> eye vitamins developed as a<br />
result <strong>of</strong> the original AREDS trial.<br />
Although she has convinced herself<br />
that she was randomly assigned to<br />
the group that is receiving placebo<br />
and not receiving a supplement,<br />
Bathum still believes in clinical<br />
trials. “It is helping learn what care<br />
is best,” she said.<br />
Georgette Bathum checks in for her eye clinic appointment with medical receptionist Julie Grim.<br />
<strong>2010</strong> ANNUAL REPORT<br />
11
PATIENT CARE continued<br />
Dr. Blodi notes that a clinical trial<br />
comparing one treatment with another<br />
under careful monitoring is the best way<br />
to demonstrate which <strong>of</strong> the treatments<br />
is best. This careful monitoring includes<br />
photographs or optical coherence<br />
tomography <strong>of</strong> the affected eyes at each<br />
visit. This allows researchers to understand<br />
how the medications being studied are<br />
working at every point in time, not just at<br />
the beginning and end <strong>of</strong> the study. The<br />
technician prepares the patient for an<br />
injection, if one is needed. This includes<br />
numbing the eye, using a sterile prep and<br />
getting the medication. Medications are<br />
prepared by the UW Health pharmacist in<br />
the building. “This is a real team effort,”<br />
Dr. Blodi said.<br />
Bathum had been losing her vision rapidly<br />
soon after she began seeing Dr. Blodi.<br />
She developed the wet form <strong>of</strong> macular<br />
degeneration and began receiving<br />
injections <strong>of</strong> Lucentis into her eye. The<br />
injections were proven in earlier studies<br />
to improve vision and delay blindness in<br />
people with the onset <strong>of</strong> wet AMD.<br />
As a result <strong>of</strong> the injections, Georgette<br />
has been able to keep up with her active<br />
lifestyle. She and her daughter, Mary<br />
Elizabeth Bathum, own a condominium in a<br />
co-housing complex in Madison. Georgette<br />
is able to go to exercise class, take classes<br />
at the <strong>University</strong> <strong>of</strong> <strong>Wisconsin</strong> and attend<br />
courses in the UW Arboretum, as well as<br />
volunteer at a local nursing home.<br />
Barbara Blodi, MD, chats with her patient, Georgette Bathum, and Georgette’s daughter Mary Elizabeth Bathum. Mary Elizabeth<br />
accompanies her mother to most eye clinic appointments.<br />
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UW DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES
“This treatment has allowed me to<br />
continue doing the things I enjoy,”<br />
Georgette said.<br />
Mary Elizabeth, who is able to drive<br />
her mom to most appointments –<br />
driving immediately after an injection<br />
is not recommended – said that<br />
having the injections as an option for<br />
her mother was a great relief. “It felt<br />
good to have some hope,” she said.<br />
“This treatment has<br />
allowed me to continue<br />
doing the things I enjoy.”<br />
Georgette Bathum<br />
Georgette agreed. “Any hope was<br />
wonderful,” she said. “I still feel<br />
that way.”<br />
Although the AREDS2 study will be<br />
completed in about a year, Georgette<br />
will request to remain Dr. Blodi’s<br />
patient from now on. And Dr. Blodi is<br />
looking forward to knowing Georgette<br />
and Mary Elizabeth even better.<br />
Barbara Blodi, MD, examines Georgette Bathum’s eyes during a check-up visit. Georgette’s daughter, Mary Elizabeth Bathum,<br />
looks on.<br />
<strong>2010</strong> ANNUAL REPORT<br />
13
EDUCATION<br />
RESIDENCY PREPARES DOCTORS FOR FUTURE PRACTICE<br />
A Day in the Life<br />
Timothy Daley, MD, listens during a Grand Rounds lecture. The talks are held weekly and help keep<br />
residents, faculty and others abreast <strong>of</strong> the latest news in ophthalmology.<br />
When Timothy Daley, MD,<br />
stepped <strong>of</strong>f the elevator<br />
to greet his first patient<br />
<strong>of</strong> the day, he had already been<br />
working for more than two hours.<br />
As chief resident in the <strong>Department</strong><br />
<strong>of</strong> Ophthalmology and Visual<br />
Sciences, Dr. Daley not only attends<br />
the same lectures and education<br />
programs as his colleagues, he<br />
<strong>of</strong>ten is involved in planning and<br />
organizing them as well.<br />
On Fridays, the nine residents<br />
in the <strong>University</strong> <strong>of</strong> <strong>Wisconsin</strong><br />
School <strong>of</strong> Medicine and Public<br />
Health ophthalmology residency<br />
start their day at 7 a.m. with<br />
Retina Workout. Each week a UW<br />
<strong>Department</strong> <strong>of</strong> Ophthalmology and<br />
Visual Sciences retina specialist<br />
goes over cases <strong>of</strong> interest and the<br />
group discusses the issues and<br />
treatment options.<br />
Following Retina Workout, the<br />
entire group <strong>of</strong> residents moves<br />
across the hall to Grand Rounds.<br />
Organized by each year’s chief<br />
resident, Grand Rounds is a<br />
Continuing Medical Educationapproved<br />
lecture series that<br />
features physicians and researchers<br />
from within the <strong>Department</strong>, others<br />
within the UW System and outside<br />
visiting pr<strong>of</strong>essors. The topics<br />
range from basic science talks, to<br />
interesting patient cases, to issues<br />
that affect the practice <strong>of</strong> medicine<br />
in general (such as patient<br />
safety), and to new practices and<br />
procedures in ophthalmology.<br />
When Grand Rounds ended at<br />
8:30 a.m. on a recent Friday, Dr.<br />
Daley hurried to the William S.<br />
Middleton Memorial Veterans<br />
Affairs Hospital, connected to the<br />
UW Hospital and Clinics, to see his<br />
first patients <strong>of</strong> the day. Dr. Daley<br />
spotted Claire Clark immediately,<br />
and led him down the hall to an<br />
exam room.<br />
“Should we take this eye patch<br />
<strong>of</strong>f?” Dr. Daley asked, as he gently<br />
removed the patch that had<br />
protected Clark’s eye since the prior<br />
day’s cataract surgery.<br />
Clark answered yes, and was<br />
thrilled with his improved vision<br />
after the procedure. “This is<br />
heaven,” Clark said. “I was walking<br />
like I was drunk before.”<br />
Dr. Daley checked Clark’s eye<br />
and explained the eye drops he<br />
would need to use for the next<br />
several weeks.<br />
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UW DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES
“If you have any questions, call right away,”<br />
Dr. Daley reminded his patient. “In fact, I’m<br />
on call this weekend, so if you call, I’ll be the<br />
person you talk to.”<br />
“We really take pride in the<br />
fact that our patient outcomes<br />
for cataract surgery are better<br />
than the national standard<br />
whether residents are involved<br />
or not.”<br />
Andrew Thliveris, MD, PhD<br />
As the senior resident at the Veterans Affairs<br />
Hospital, Dr. Daley examines patients on<br />
his own. His work includes regular eye clinic<br />
exams, pre-surgery check-ups, surgery and<br />
post-surgery check-ups as well. An attending<br />
physician on staff at the UW <strong>Department</strong> <strong>of</strong><br />
Ophthalmology and Visual Sciences reviews<br />
every chart and sees patients if Dr. Daley<br />
requests. In addition, the attending physician<br />
sees every patient who is scheduled for a<br />
procedure such as laser or surgery.<br />
On this day the attending physician was<br />
Andrew Thliveris, MD, PhD, chief <strong>of</strong> the<br />
Ophthalmology Service at the Veterans<br />
Affairs Hospital. First and second year<br />
residents have their cases followed more<br />
closely. And because an attending physician<br />
looks over every chart, the department can<br />
be sure residents are asking for help when it<br />
is needed.<br />
Timothy Daley, MD, walks with his first patient <strong>of</strong> the day, Claire Clark, <strong>of</strong> Lyndon Station. Clark had surgery the day before to<br />
remove a cataract and replace it with an intraocular lens.<br />
<strong>2010</strong> ANNUAL REPORT<br />
15
EDUCATION continued<br />
For Dr. Thliveris and other faculty at the UW,<br />
teaching residents is only possible if high quality<br />
patient care is maintained. “We really take<br />
pride in the fact that our patient outcomes for<br />
cataract surgery are better than the national<br />
standard whether residents are involved or not,”<br />
Dr. Thliveris said. “A high standard <strong>of</strong> care is the<br />
expectation here.”<br />
Dr. Daley’s next patient is scheduled for surgery<br />
in the next few weeks. Dr. Daley explained all<br />
the risks and the benefits <strong>of</strong> a complicated<br />
operation, combining cataract and retinal<br />
surgery. Dr. Daley will perform cataract removal<br />
with implantation <strong>of</strong> a new lens and a faculty<br />
retina specialist will then do the retinal surgery.<br />
Making sure his patient understands exactly<br />
what is involved is an important part <strong>of</strong> Dr.<br />
Daley’s job. He took time to answer every<br />
question and explain steps in detail.<br />
After seeing several more patients, Dr. Daley<br />
prepared for that day’s surgery.<br />
As residents gain more experience, they are<br />
allowed to operate more independently, but<br />
attending staff is always scrubbed in in case<br />
their skills are needed. As a senior resident on<br />
this VA rotation, Dr. Daley also performs surgery<br />
on Friday afternoons, under the watchful eyes <strong>of</strong><br />
Assistant Pr<strong>of</strong>essor Daniel Knoch, MD.<br />
Surgical procedures are carefully orchestrated,<br />
with a nurse anesthetist, a nurse and an<br />
operating room technician, in addition to Dr.<br />
Daley, Dr. Knoch and the patient. The patient<br />
confessed on this Friday before the Green Bay<br />
Packers played their arch-rival Chicago Bears for<br />
the Division Championship that he was pulling<br />
for the Bears.<br />
Timothy Daley, MD, examines the eyes <strong>of</strong> Clarence Dahmen, Waunakee, who is preparing for surgery in the next few weeks.<br />
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UW DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES
“That’s OK,” Dr. Daley quipped.<br />
“We’ll take good care <strong>of</strong> you<br />
anyway.”<br />
Cataract surgery is very common<br />
and Dr. Daley is experienced.<br />
But even so, Dr. Knoch served as<br />
surgical assistant and continually<br />
<strong>of</strong>fered suggestions and used every<br />
teachable moment to increase Dr.<br />
Daley’s knowledge <strong>of</strong> ophthalmology<br />
and ophthalmic surgery.<br />
After the procedure, residents<br />
and attending physicians can<br />
review video from the operating<br />
room’s microscope. The video<br />
tracks everything from the view<br />
<strong>of</strong> the surgeon, so everyone can<br />
learn from the experience. “Even<br />
when things go well, you can<br />
learn something to refine your<br />
technique,” Dr. Daley said. “We<br />
want better outcomes and we want<br />
to be more efficient.”<br />
Surgery on Friday means patient<br />
visits on Saturday, even if he weren’t<br />
on call. “Surgery is an honor,” Dr.<br />
Daley said. “I will happily come in<br />
and see my patients on Saturdays.”<br />
Dr. Daley, who completed medical<br />
school, internship and now his<br />
residency at the UW, will also obtain<br />
his fellowship training at the UW<br />
<strong>Department</strong> <strong>of</strong> Ophthalmology and<br />
Visual Sciences. He is choosing<br />
to concentrate on pediatric<br />
ophthalmology and adult strabismus<br />
(eye muscle problems).<br />
Dr. Daley chats with Lyne Kuhn, an ophthalmology technician at the Veterans<br />
Affairs Hospital.<br />
But he likes his rotations at the<br />
VA Hospital. “You see a lot <strong>of</strong><br />
interesting patients. It’s very<br />
rewarding. My grandfather was a<br />
World War II veteran,” he said. “A<br />
lot <strong>of</strong> my patients here remind me<br />
<strong>of</strong> him.”<br />
Dr. Daley made his choice for<br />
ophthalmology when he was<br />
covering the emergency room<br />
during medical school. “A young<br />
man came in with a stick in his eye<br />
and I asked if I could follow along.”<br />
Dr. Knoch was the senior resident<br />
on that case and Gary Sterken,<br />
MD, a faculty member in the<br />
<strong>Department</strong>, was the attending<br />
physician. “Other medical staff<br />
members were turning away, but<br />
I was really interested in how they<br />
were going to help him,” Dr. Daley<br />
said. “Dr. Knoch performed a<br />
simple and elegant procedure, with<br />
just a couple <strong>of</strong> stitches. The patient<br />
ended up having a great outcome,<br />
and I was hooked from then on.”<br />
As his years as a resident near<br />
their end, Dr. Daley feels confident<br />
in treating a large variety <strong>of</strong> eye<br />
diseases. “During the interview<br />
process (for residency programs)<br />
you have the chance to see what it’s<br />
like in other places. I’m really glad I<br />
am able to be here at the UW.” UW<br />
faculty and patients like Mr. Clark<br />
are really glad that Dr. Daley is here<br />
at the UW too.<br />
<strong>2010</strong> ANNUAL REPORT<br />
17
DONORS<br />
MOM’S MEMORY LIVES ON<br />
Donation Supports Care for Patients with AMD<br />
Chloe Gomez (clockwise from bottom left) her mother, Melissa Gomez, Melissa’s mother,<br />
Barbara Hevrin and Barbara’s mother Donna Fair. Fair’s family made a donation to UW Health<br />
Rockford Eye Clinic in her memory after she passed away in <strong>2010</strong>.<br />
Donna Fair’s<br />
children gathered<br />
recently and<br />
reminisced about<br />
their mom. Fair, who<br />
passed away in June<br />
<strong>2010</strong>, was remembered<br />
for her battle with<br />
lung cancer and for<br />
her generous spirit.<br />
And they recalled her<br />
“Dr. Mom” treatment<br />
<strong>of</strong> her children and<br />
grandchildren, as well<br />
as her ability to be a sounding<br />
board who <strong>of</strong>fered advice<br />
as needed.<br />
Ronald Danis, MD<br />
But she was also remembered<br />
for advocating for herself. And<br />
it wasn’t just her children who<br />
remembered that part <strong>of</strong> Fair.<br />
Ronald Danis, MD, who was her<br />
ophthalmologist at UW Health Eye<br />
Clinic - Rockford, recalled that she<br />
wanted to try Avastin injections<br />
for her age-related macular<br />
degeneration (AMD).<br />
“She had been a patient for a<br />
while,” Dr. Danis recalled. “Her<br />
vision was 20-400 for about a<br />
year.” Fair had given up driving,<br />
had given up reading and had new<br />
challenges when taking care <strong>of</strong><br />
her home.<br />
Her youngest<br />
daughter, Carol<br />
Larson, <strong>of</strong> Loves Park,<br />
Ill., used tape and a<br />
black marker to put<br />
arrows on Fair’s stove<br />
and other appliances<br />
so that Fair could<br />
continue the chores <strong>of</strong><br />
daily life and continue<br />
to live at home. “It was<br />
really hard to watch<br />
her go through that,”<br />
Larson recalled.<br />
So one day Fair showed up for<br />
her appointment with Dr. Danis<br />
with an article about Avastin, a<br />
then-new drug that was helping<br />
people with AMD improve their<br />
vision. News about clinical trials<br />
<strong>of</strong> Avastin had recently been<br />
presented to ophthalmologists,<br />
but Dr. Danis had limited personal<br />
experience with the drug.<br />
“She gave me the newspaper<br />
article and told me she wanted<br />
me to try that,” Dr. Danis said. “I<br />
was hesitant. The drug works best<br />
when used early in this disease<br />
process and we had no indication<br />
that it would restore vision in<br />
someone who had been legally<br />
blind for more than a year. Without<br />
having clinical trial information,<br />
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UW DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES
I told her I was skeptical it would help her<br />
longstanding poor vision.”<br />
Fair insisted. After all, she believed in advocating<br />
for herself. Following careful consideration, Dr.<br />
Danis started a series <strong>of</strong> monthly injections in<br />
one eye.<br />
A month after the first injection, Fair returned<br />
to the clinic. “When we checked her vision, she<br />
could not see any better, but she felt like she<br />
was seeing more clearly,” Dr. Danis said. “Then<br />
she asked to have injections in both eyes.”<br />
Miraculously, Fair’s vision improved. Within<br />
a few months, her vision improved to 20-<br />
40 and she was able to drive herself to her<br />
appointments. She was able to read again,<br />
something she had always loved and had<br />
missed. She took down the telephone with<br />
oversize numbers and replaced it with a normal<br />
phone. She was able to pull the taped-on labels<br />
<strong>of</strong>f her appliances. She could see.<br />
It was Fair herself who said her restored vision<br />
was a miracle. She was grateful to be able to<br />
enjoy her freedom. So when she was diagnosed<br />
with lung cancer, and her children and friends<br />
prayed for a miracle cure to the cancer, Fair<br />
didn’t push it.<br />
“She said ‘God doesn’t give that many miracles,<br />
and I’ve had mine.’ I still prayed for a miracle,”<br />
Larson said.<br />
“We all did,” added her sister, Barbara Hevrin, <strong>of</strong><br />
Rockford, Ill.<br />
Even when she was fighting the cancer, and sick<br />
from chemotherapy treatments, she saw Dr.<br />
Danis for her Avastin injections.<br />
“She was such a neat lady,” Dr. Danis said. “She<br />
was one <strong>of</strong> the most perseverant folks I’ve met.<br />
Four <strong>of</strong> Donna Fair’s children, (back row) Carol Larson, David Barrie, Barbara Hevrin and Duane Barrie, gathered recently to<br />
remember their mom.<br />
<strong>2010</strong> ANNUAL REPORT<br />
19
DONORS continued<br />
Even when she was ill, she always<br />
came in for her eye visits. She was<br />
positive and always seemed grateful<br />
for her vision.”<br />
Indeed, she was grateful. Whether<br />
cooking her famous potato salad<br />
and pies or spending time with<br />
her family at the lake, Donna<br />
Fair loved being able to see.<br />
With grandchildren and great<br />
grandchildren to love, it was a<br />
pleasure to her to watch them<br />
grow up.<br />
“We were using<br />
technology and<br />
treatment that has been<br />
developed through the<br />
collaborative efforts <strong>of</strong><br />
thousands <strong>of</strong> people.”<br />
Ronald Danis, MD<br />
Being grateful for her support, it<br />
seemed natural that when Fair<br />
passed away, her family would use<br />
the memorial gifts to help other<br />
people. They selected three charities<br />
to share in the gifts given in their<br />
mother’s memory. In addition to her<br />
church and hospice, both <strong>of</strong> which<br />
provided comfort and support, the<br />
family chose the UW Health Eye<br />
Clinic-Rockford, which gave her<br />
a miracle.<br />
When the family made the donation<br />
to the Eye Clinic, they asked that it<br />
be used to improve care for other<br />
patients with macular degeneration.<br />
It will go to help fund advanced<br />
imaging machines that continue to<br />
help improve treatment <strong>of</strong> people<br />
with AMD.<br />
The family thinks Fair would like the<br />
choices they made. “She would like<br />
knowing this was going to help other<br />
people,” said her son, David Barrie <strong>of</strong><br />
Winnebago, Ill.<br />
David Barrie listens as his sister, Carol Larson, recalls her mother’s wish to instill<br />
self-reliance in her children, while helping others as well.<br />
When their father died, the family<br />
didn’t have the opportunity to use<br />
memorial donations for charity.<br />
But when their stepfather, George<br />
Fair, died, Donna decided to use the<br />
money to support community areas<br />
George believed in. She was an<br />
example to her children, yet again.<br />
When patients or families make<br />
donations, physicians are not always<br />
aware <strong>of</strong> why the gift was given.<br />
Dr. Danis said he was flattered and<br />
honored that Donna thought so<br />
highly <strong>of</strong> her care. “I can’t disagree<br />
with her that this was a miracle.<br />
But I was just the conduit,” he said.<br />
“We were using technology and<br />
treatment that has been developed<br />
through the collaborative efforts <strong>of</strong><br />
thousands <strong>of</strong> people.”<br />
Beyond regaining her sight, Donna<br />
liked going to the Eye Clinic, and<br />
staff there liked her, too. “They<br />
would come around the counter<br />
and hug her,” Hevrin said. “They<br />
were so friendly. We wanted to<br />
make this gift as a thank you for<br />
being so nice to her. Look at what<br />
this meant to her.”<br />
Donna will be remembered for<br />
touching the hearts <strong>of</strong> all who knew<br />
her, and by way <strong>of</strong> her gift, she will<br />
be helping improve vision in people<br />
who have never had the enjoyment<br />
<strong>of</strong> getting to meet her.<br />
20<br />
UW DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES
<strong>2010</strong> Selected Grants<br />
Albert, Daniel<br />
AMA Archives <strong>of</strong> Ophthalmology Journal Editorship<br />
NATIONAL CHILDHOOD CANCER FOUNDATION<br />
Children’s Oncology Group<br />
Brandt, Curtis<br />
RRH Gene Therapy for Retinal Degenerative Diseases<br />
DHHS, PHS, NIH<br />
Virion Sialic Acid and HSV Ocular Infection<br />
Colley, Nansi<br />
DHHS, PHS, NIH<br />
Molecular Studies <strong>of</strong> Retinal<br />
Degeneration in Drosophila<br />
Cruickshanks, Karen<br />
GEORGE WASHINGTON UNIVERSITY<br />
Epidemiology <strong>of</strong> Age-related Hearing Loss<br />
DHHS, PHS, NIH<br />
Familial and Birth Cohort<br />
Effects on the Aging Senses<br />
Danis, Ronald<br />
GEORGE WASHINGTON UNIVERSITY<br />
Diabetes Prevention Program Outcomes Study<br />
WAKE FOREST UNIVERSITY<br />
Action to Control Cardiovascular<br />
Risk in Diabetes: ACCORD Study<br />
GEORGE WASHINGTON UNIVERSITY<br />
Treatment Options for Type 2<br />
Diabetes in Adolescents and Youth<br />
DHHS, PHS, NIH<br />
Ocular Complications <strong>of</strong> AIDS:<br />
Photograph Reading Center<br />
DHHS, PHS, NIH<br />
Fundus Photograph Reading Center<br />
to Support a Multi-Center, Randomized<br />
Trial <strong>of</strong> Luetin, Zeaxanthin, and Omega-3<br />
LCPUFAS in Age-Related<br />
Macular Edema (AREDS II)<br />
Kalil, Ronald<br />
DOD, ARMY Does the Treatment <strong>of</strong> Breast Cancer with<br />
Adjuvant Chemotherapy Interfere with<br />
Hippocampal Neurogenesis and with<br />
Hippocampal-Dependent Cognitive Function?<br />
Kaufman, Paul<br />
PFIZER, INC Regulation <strong>of</strong> outflow facility by gene transfer<br />
UNIVERSITY OF NORTH CAROLINA<br />
Extra-Lenticular Aspects <strong>of</strong><br />
Accommodation and Presbyopia<br />
DHHS, PHS, NIH<br />
ARRA Aqueous humor<br />
dynamics studies in vivo and in vitro<br />
Klein, Barbara<br />
RRF Prevalence and Incident Changes<br />
in Retinal Vascular Caliber Associated<br />
with Medication and Supplement Use<br />
Klein, Ronald<br />
ADA American Diabetes Association<br />
- Mentor-Based Doctoral Fellowship<br />
ADA The epidemiology <strong>of</strong> diabetic complications<br />
UNIVERSITY OF SOUTHERN CALIFORNIA<br />
Los Angeles Latino Eye Study<br />
Klein, Ronald; Klein, Barbara<br />
UNIVERSITY OF WASHINGTON<br />
Multi-Ethnic Study <strong>of</strong> Atherosclerosis (MESA II)<br />
DHHS, PHS, NIH<br />
Epidemiology <strong>of</strong> Age-Related Macular<br />
Degeneration and Other Retinal Diseases<br />
Levin, Leonard<br />
RRH Pharmacological Protection Of<br />
Endothelial Cells For Retinal Vascular Disease<br />
Mares, Julie; Blodi, Barbara; Chappell, Richard;<br />
Engelman, Corinne; Sarto, Gloria<br />
DHHS, PHS, NIH<br />
Diet and Lifestyle Factors Reducing<br />
Risk for Age-Related Eye Disease<br />
McLellan, Gillian<br />
DHHS, PHS, NIH<br />
Structural and functional characterization<br />
<strong>of</strong> a novel model for glaucoma research<br />
Nickells, Robert<br />
DHHS, PHS, NIH<br />
Characterization <strong>of</strong> RGC<br />
death susceptibility alleles<br />
DHHS, PHS, NIH<br />
Molecular mechanism <strong>of</strong><br />
retinal ganglion cell death<br />
Sheibani, Nader<br />
ADA CYP1B1, NF-kB , and Regulation <strong>of</strong> Angiogenesis<br />
DHHS, PHS, NIH<br />
PEDF and Diabetic Retinopathy<br />
DHHS, PHS, NIH<br />
PECAM-1 and Retinopathy <strong>of</strong> Prematurity<br />
Sheibani, Nader; Assadi, Amir; Assadi-Porter, Fariba<br />
DHHS, PHS, NIH<br />
ARRA Integrated Multidisciplinary<br />
Strategies for Detection<br />
<strong>of</strong> Diabetic Retinopathies<br />
Sheibani, Nader; Jefcoate, Colin<br />
DHHS, PHS, NIH<br />
ARRA CYP1B1 and Retinopathy <strong>of</strong> Prematurity<br />
KEY<br />
Federal funding:<br />
NIH = National Institutes <strong>of</strong> Health<br />
Foundation:<br />
ADA = American Diabetes Association<br />
AMA = American Medical Association<br />
JDRF = Juvenile Diabetes Research Foundation<br />
RRF = Retina Research Foundation<br />
<strong>2010</strong> ANNUAL REPORT<br />
21
clinical & research<br />
faculty & staff <strong>2010</strong><br />
Julia B. Agapov, MD, DO<br />
Assistant Pr<strong>of</strong>essor<br />
Glaucoma, anterior<br />
segment & cataract<br />
surgery<br />
Daniel M. Albert, MD, MS<br />
Frederick Allison Davis and<br />
Lorenz E. Zimmerman<br />
Pr<strong>of</strong>essor & Chair Emeritus<br />
Ocular oncology,<br />
ophthalmic pathology,<br />
comprehensive<br />
ophthalmology<br />
Michael M. Altaweel, MD<br />
Associate Pr<strong>of</strong>essor<br />
Retina, vitreous, macula,<br />
ocular melanoma<br />
Richard E. Appen, MD<br />
Pr<strong>of</strong>essor Emeritus<br />
Neuro-ophthalmology<br />
Yonca O. Arat, MD<br />
Assistant Pr<strong>of</strong>essor<br />
Comprehensive<br />
ophthalmology,<br />
cataract surgery<br />
Neal P. Barney, MD<br />
Associate Pr<strong>of</strong>essor<br />
Cornea & external<br />
disease, cornea &<br />
cataract surgery, uveitis,<br />
ocular immunology<br />
Barbara A. Blodi, MD<br />
Pr<strong>of</strong>essor<br />
Retinal diseases including<br />
macular degeneration<br />
and diabetic retinopathy<br />
Yasmin S. Bradfield, MD<br />
Associate Pr<strong>of</strong>essor<br />
Pediatric ophthalmology<br />
& strabismus, retinopathy<br />
<strong>of</strong> prematurity, pediatric<br />
cataract surgery & intraocular<br />
lens implantation, pediatric<br />
eyelid surgery, pediatric<br />
glaucoma<br />
Curtis R. Brandt, PhD<br />
Pr<strong>of</strong>essor<br />
Virology, cell & molecular<br />
biology, genetic mapping<br />
& recombinant techniques,<br />
gene therapy<br />
Cat N. Burkat, MD<br />
Assistant Pr<strong>of</strong>essor<br />
Ophthalmic<br />
reconstructive<br />
& cosmetic surgery<br />
Suresh R. Chandra, MD<br />
Pr<strong>of</strong>essor<br />
Vitreoretinal disease,<br />
macular disease, ocular<br />
melanoma, trauma,<br />
international<br />
ophthalmology<br />
Nansi Jo Colley, PhD<br />
Pr<strong>of</strong>essor<br />
Molecular/genetic<br />
studies <strong>of</strong> retinal<br />
degeneration in<br />
Drosophila<br />
Eugene D. Cropp, OD<br />
Clinical Optometrist<br />
Optometry<br />
Karen J. Cruickshanks, PhD<br />
Pr<strong>of</strong>essor<br />
Epidemiology <strong>of</strong> agerelated<br />
ocular disorders,<br />
hearing loss, diabetes<br />
Janet Cushing, OD<br />
Clinical Optometrist<br />
Optometry<br />
Ronald P. Danis, MD<br />
Pr<strong>of</strong>essor, Director <strong>of</strong> the<br />
Fundus Photograph<br />
Reading Center<br />
Macular degeneration,<br />
diabetic retinopathy,<br />
retinal vascular diseases<br />
& posterior ocular<br />
inflammatory disorders<br />
Matthew D. Davis, MD<br />
Pr<strong>of</strong>essor Emeritus<br />
Vitreoretinal disease,<br />
diabetic retinopathy,<br />
clinical trials<br />
Richard K. Dortzbach, MD<br />
Pr<strong>of</strong>essor Emeritus<br />
Ophthalmic plastic &<br />
reconstructive surgery,<br />
surgical techniques<br />
Ivy J. Dreizin, MD<br />
Associate Pr<strong>of</strong>essor<br />
Neuro-ophthalmology<br />
Michael J. Feifarek, MD<br />
Instructor<br />
Comprehensive<br />
ophthalmology<br />
Thomas D. France, MD<br />
Pr<strong>of</strong>essor Emeritus<br />
Pediatric ophthalmology<br />
& strabismus, amblyopia,<br />
visual function testing<br />
David M. Gamm, MD, PhD Justin L. Gottlieb, MD<br />
Assistant Pr<strong>of</strong>essor<br />
Associate Pr<strong>of</strong>essor<br />
Pediatric ophthalmology Retina, vitreous, macula<br />
& strabismus, retinopathy<br />
<strong>of</strong> prematurity, pediatric<br />
cataract surgery &<br />
intraocular lens implantation,<br />
pediatric glaucoma<br />
Gregg A. Heatley, MD<br />
Associate Pr<strong>of</strong>essor<br />
Vice-Chair/Clinical<br />
Glaucoma, anterior<br />
segment & cataract<br />
surgery<br />
Michael S. Ip, MD<br />
Associate Pr<strong>of</strong>essor<br />
Vitreoretinal surgery<br />
for diabetic retinopathy<br />
and retinal detachment,<br />
treatment <strong>of</strong> age-related<br />
macular degeneration,<br />
clinical trials research<br />
Celeste K. Jend, OD<br />
Clinical Optometrist<br />
Optometry<br />
Ronald E. Kalil, PhD<br />
Pr<strong>of</strong>essor<br />
Neural cell death &<br />
repair after brain damage<br />
Paul L. Kaufman, MD<br />
Peter A. Duehr Pr<strong>of</strong>essor<br />
& Chair<br />
Glaucoma, aqueous<br />
humor dynamics, anterior<br />
segment physiology &<br />
pharmacology, presbyopia<br />
Barbara E.K. Klein, MD, MPH<br />
Pr<strong>of</strong>essor<br />
Glaucoma, comprehensive<br />
ophthalmology, cataracts,<br />
diabetic retinopathy,<br />
epidemiology, preventive<br />
medicine<br />
Ronald Klein, MD, MPH<br />
Pr<strong>of</strong>essor<br />
Vitreoretinal disease,<br />
diabetic retinopathy,<br />
age-related eye diseases,<br />
epidemiology<br />
22<br />
UW DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES
Daniel W. Knoch, MD<br />
Assistant Pr<strong>of</strong>essor<br />
Comprehensive<br />
ophthalmology,<br />
cataract surgery<br />
Burton J. Kushner, MD<br />
Pr<strong>of</strong>essor<br />
Pediatric ophthalmology<br />
& strabismus, amblyopia,<br />
surgical techniques<br />
Aparna Lakkaraju, PhD<br />
Assistant Pr<strong>of</strong>essor<br />
Retinal cell biology,<br />
pathogenesis <strong>of</strong> retinal<br />
degenerations,<br />
identification <strong>of</strong><br />
therapeutic targets<br />
Leonard A. Levin, MD, PhD<br />
Pr<strong>of</strong>essor<br />
Neuro-ophthalmology,<br />
ganglion cell death<br />
Mark J. Lucarelli, MD<br />
Pr<strong>of</strong>essor<br />
Oculoplastic, cosmetic<br />
facial and orbital surgery<br />
Julie A. Mares, PhD<br />
Pr<strong>of</strong>essor<br />
Epidemiology <strong>of</strong> eye<br />
disease, nutritional<br />
epidemiology<br />
Michele M. Martin, OD<br />
Clinical Optometrist<br />
Optometry<br />
Frank L. Myers, MD<br />
Pr<strong>of</strong>essor<br />
Retina<br />
Sarah M. Nehls, MD<br />
Assistant Pr<strong>of</strong>essor<br />
Vice-Chair/CME & Faculty<br />
Development<br />
Refractive surgery, cornea<br />
& external disease, cornea<br />
& cataract surgery, uveitis<br />
Robert W. Nickells, PhD<br />
Pr<strong>of</strong>essor<br />
Vice-Chair/Research<br />
Molecular biology <strong>of</strong> cell<br />
death in glaucoma &<br />
retinoblastoma<br />
T. Michael Nork, MD, MS<br />
Associate Pr<strong>of</strong>essor<br />
Diseases & surgery <strong>of</strong><br />
the retina & vitreous<br />
Cameron F. Parsa, MD<br />
Associate Pr<strong>of</strong>essor<br />
Pediatric<br />
ophthalmology and<br />
strabismus, neuroophthalmology<br />
Richard W. Patterson, OD<br />
Clinical Optometrist<br />
Optometry<br />
Todd W. Perkins, MD<br />
Pr<strong>of</strong>essor<br />
Glaucoma, normal<br />
tension glaucoma,<br />
implant devices,<br />
cataract surgery<br />
Arthur S. Polans, PhD<br />
Pr<strong>of</strong>essor<br />
Cancer-related<br />
ocular pathologies<br />
Heather A.D. Potter, MD<br />
Assistant Pr<strong>of</strong>essor<br />
Comprehensive<br />
ophthalmology,<br />
ophthalmic pathology,<br />
cataract surgery ,<br />
refractive surgery<br />
Patricia C. Sabb, MD<br />
Assistant Pr<strong>of</strong>essor<br />
Comprehensive<br />
ophthalmology,<br />
cataract surgery,<br />
refractive surgery<br />
Stephen K. Sauer, MD<br />
Assistant Pr<strong>of</strong>essor<br />
Residency Director<br />
Comprehensive<br />
ophthalmology,<br />
cataract surgery<br />
Nader Sheibani, PhD<br />
Associate Pr<strong>of</strong>essor<br />
Diabetic retinopathy,<br />
retinopathy <strong>of</strong><br />
prematurity, animal<br />
models and retinal<br />
vascular cell biology and<br />
signal transduction<br />
Gary W. Sterken, MD<br />
Assistant Pr<strong>of</strong>essor<br />
Comprehensive<br />
ophthalmology,<br />
cataract surgery,<br />
glaucoma<br />
Thomas S. Stevens, MD<br />
Pr<strong>of</strong>essor<br />
Vitreoretinal disease,<br />
macular disease, diabetic<br />
retinopathy, proliferative<br />
vitreoretinopathy<br />
Michael C. Struck, MD John E. Temprano, MD<br />
Associate Pr<strong>of</strong>essor Associate Pr<strong>of</strong>essor<br />
Pediatric ophthalmology Comprehensive<br />
& strabismus, retinopathy ophthalmology,<br />
<strong>of</strong> prematurity, pediatric cataract surgery<br />
cataract surgery &<br />
intraocular lens implantation,<br />
pediatric glaucoma<br />
Andrew T. Thliveris, MD, PhD<br />
Associate Pr<strong>of</strong>essor<br />
Assistant Residency Director<br />
Chief <strong>of</strong> Ophthalmology<br />
William S. Middleton<br />
Memorial Veterans Hospital<br />
Comprehensive ophthalmology,<br />
cataracts, ocular genetics<br />
Norbert F. Toussaint, Jr., MD<br />
Assistant Pr<strong>of</strong>essor<br />
Comprehensive<br />
ophthalmology<br />
James N. Ver Hoeve, PhD<br />
Senior Scientist<br />
Visual electrophysiology<br />
Amy L. Walker, OD<br />
Clinical Optometrist<br />
Optometry<br />
<strong>2010</strong> ANNUAL REPORT<br />
23
<strong>2010</strong> clinical trials<br />
A Natural History Study <strong>of</strong> Macular<br />
Telangiectasia: The Mactel Study – Mactel<br />
Principal Investigator: Barbara A. Blodi, MD<br />
Study Coordinator: Michelle R. (Shelly) Olson<br />
Synopsis:<br />
This study is a prospective, cross-sectional study <strong>of</strong><br />
participants with a diagnosis <strong>of</strong> macular telangiectasia.<br />
Age-Related Eye Disease Study 2 (AREDS 2)<br />
Principal Investigators: Suresh R. Chandra, MD,<br />
and Barbara A. Blodi, MD<br />
Study Coordinator: Michelle R. (Shelly) Olson<br />
Synopsis:<br />
A multi-center, randomized trial <strong>of</strong> lutein, zeaxanthin,<br />
and omega-3 long-chain polyunsaturated fatty acids<br />
[docosahexaenoic acid (DHA) and eicosapentaenoic acid<br />
(EPA)] in age-related macular degeneration (AMD).<br />
Comparison <strong>of</strong> AMD Treatment Trials<br />
(CATT) Lucentis – Avastin Trial<br />
Principal Investigators: Suresh R. Chandra,<br />
MD and Michael M. Altaweel, MD<br />
Study Coordinators: Kristine A. Dietzman,<br />
Angie M. Wealti, Jennie R. Perry-Raymond<br />
Synopsis:<br />
This study seeks to evaluate the relative efficacy<br />
and safety <strong>of</strong> treatment <strong>of</strong> subfoveal neovascular<br />
AMD with Lucentis on a fixed schedule, Avastin<br />
on a fixed schedule, Lucentis on a variable<br />
schedule, and Avastin on a variable schedule.<br />
CNV Secondary to AMD Treated with Beta<br />
RadiatioN Epiretinal Therapy – NeoVista Inc.<br />
(CABERNET): NV1-114 Randomized, Prospective,<br />
Controlled Study <strong>of</strong> the NeoVista System<br />
for the Treatment <strong>of</strong> Subfoveal Choroidal<br />
Neovascularization Associated with Wet AMD<br />
Principal Investigator: Michael S. Ip, MD<br />
Study Coordinators: Kristine A. Dietzman<br />
and Guy F. Somers, RN<br />
Synopsis:<br />
The objective <strong>of</strong> the CABERNET Trial is to<br />
evaluate the safety and efficacy <strong>of</strong> focal delivery <strong>of</strong><br />
radiation for the treatment <strong>of</strong> subfoveal choroidal<br />
neovascularization (CNV) associated with wet<br />
age-related macular degeneration (AMD).<br />
Diabetic Retinopathy Clinical Research Network (DRCR)<br />
Synopsis:<br />
STUDY I: Intravitreal Ranibizumab or<br />
Triamcinolone Acetonide in Combination with Laser<br />
Photocoagulation for Diabetic Macular Edema<br />
Principal Investigator: Justin L. Gottlieb, MD<br />
Study Coordinator: Kathryn F. Burke<br />
Synopsis:<br />
The purpose <strong>of</strong> the study is to compare: 1) sham<br />
injection plus laser treatment; 2) injection <strong>of</strong> intravitreal<br />
ranibizumab (Lucentis) plus laser treatment; 3)<br />
injection <strong>of</strong> intravitreal ranibizumab plus deferred<br />
(or delayed) laser treatment; or 4) injection <strong>of</strong><br />
intravitreal triamcinolone plus laser treatment. It is a<br />
three-year study with follow-up every four weeks.<br />
Molecular Prognostic Assay for Uveal Melanoma<br />
Principal Investigator: Michael M. Altaweel, MD<br />
Study Coordinator: Guy F. Somers, RN<br />
Synopsis:<br />
This study will investigate the accuracy <strong>of</strong> a molecular<br />
test for predicting metastasis in uveal melanoma<br />
patients. This may lead to better prognostic testing<br />
and prophylactic treatment for high-risk patients.<br />
OPHTEC – Model 311 Artificial Iris Lens for the<br />
Treatment <strong>of</strong> Visual Disturbances Resulting<br />
from Partial or Total Absence <strong>of</strong> the Human Iris:<br />
Continued Access Compassionate Use Study<br />
Principal Investigator: Michael M. Altaweel, MD<br />
Study Coordinators: Kristine A. Dietzman,<br />
Jennie R. Perry-Raymond<br />
Synopsis:<br />
OPHTEC’s Model 311 Artificial Iris Intraocular Lens is a<br />
unique, single-piece lens manufactured from colored,<br />
ultraviolet light absorbing polymethylmethacrylate<br />
(PMMA). The lens is designed for implantation<br />
into an aphakic human eye for the correction <strong>of</strong><br />
visual disturbances resulting from an incomplete<br />
or totally absent iris and the correction <strong>of</strong> the<br />
spherical refractive error as necessary.<br />
Regeneron: A Randomized, Double Masked, Active<br />
Controlled Phase III Study <strong>of</strong> the Efficacy, Safety,<br />
and Tolerability <strong>of</strong> Repeated Doses <strong>of</strong> Intravitreal<br />
VEGF Trap in Subjects with Neovascular Age-<br />
Related Macular Degeneration (VGFT-OD-0605)<br />
Principal Investigator: Michael M. Altaweel, MD<br />
Study Coordinators: Angie M. Wealti,<br />
Kristine A. Dietzman, Jennie R. Perry-Raymond<br />
Synopsis:<br />
The purpose <strong>of</strong> this study is to assess the efficacy<br />
24<br />
UW DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES
<strong>of</strong> intravitreal (ITV) administered VEGF Trap<br />
compared to ranibizumab in a non-inferiority<br />
paradigm in preventing moderate vision loss in<br />
subjects with all subtypes <strong>of</strong> neovascular AMD.<br />
SK MD7110852 EYE DROP STUDY (A Phase 2b<br />
Dose-Ranging Study <strong>of</strong> Pazopanib Eye Drops versus<br />
Ranibizumab Intravitreal Injections for the Treatment<br />
<strong>of</strong> Neovascular Age-Related Macular Degeneration)<br />
Principal Investigator: Michael M. Altaweel, MD<br />
Study Coordinator: Angie R. Wealti<br />
Synopsis:<br />
A multicenter, randomized, parallel-group, doublemasked<br />
eye drops, and active-controlled study. In<br />
addition to 5 investigational daily-dosed pazopanib eye<br />
drop arms, there will be two additional treatment arms.<br />
PEDIG ~ Intermittent Exotropia Study 1. A Randomized<br />
Trial <strong>of</strong> Bilateral Lateral Rectus Recession versus<br />
Unilateral Lateral Rectus Recession with Medial<br />
Rectus Resection for Intermittent Exotropia<br />
Principal Investigator: Yasmin S. Bradfield, MD<br />
Study Coordinator: Barbara H. Soderling,<br />
Guy F. Somers, RN<br />
Synopsis:<br />
To evaluate the effectiveness <strong>of</strong> bilateral lateral<br />
rectus muscle recession versus unilateral lateral<br />
rectus recession with medial rectus resection<br />
procedures for the treatment <strong>of</strong> basic type and pseudo<br />
divergence excess type intermittent exotropia.<br />
Randomization (1:1) to surgical correction <strong>of</strong><br />
IXT with a bilateral lateral rectus recession<br />
(BLRrec) or a unilateral lateral rectus recession<br />
with medial rectus resection (R&R).<br />
Home Vision Monitoring in AREDS2 for Progression<br />
to NeoVascular AMD Using the ForeseeHome Device<br />
Principal Investigator: Suresh R. Chandra, MD<br />
and Barbara A. Blodi, MD<br />
Study Coordinator: Kathryn F. Burke<br />
Synopsis:<br />
The overall objective <strong>of</strong> this two-arm randomized<br />
clinical trial is to determine if home monitoring using the<br />
comprehensive visual field and telemedicine solution based<br />
on the ForeseeHome device in AREDS2 for participants<br />
at high risk <strong>of</strong> progression to neovascular AMD improves<br />
detection <strong>of</strong> progression to choroidal neovascularization<br />
(CNV) when compared with standard care.<br />
ALCON C-10-004. A Phase 3B, Multicenter,<br />
Randomized, Double-Masked, Parallel-Group,<br />
Active-Controlled Study <strong>of</strong> the Safety and<br />
Efficacy <strong>of</strong> Difluprednate Ophthalmic Emulsion,<br />
0.05% 4 times daily and Prednisolone Acetate<br />
Ophthalmic Suspension, 1.0% 4 times daily<br />
for the Treatment <strong>of</strong> Inflammation Following<br />
Cataract Surgery in children 0 to 3 years <strong>of</strong> age<br />
Principal Investigator: Michael C. Struck, MD<br />
Sub-Investigator: Yasmin S. Bradfield, MD<br />
Study Coordinators: Guy F. Somers, RN,<br />
Barbara H. Soderling<br />
Synopsis:<br />
To compare, in a pediatric population 0 to 3 years <strong>of</strong> age,<br />
the safety and efficacy <strong>of</strong> Durezol and Pred Forte for the<br />
treatment <strong>of</strong> inflammation following cataract surgery.<br />
OPHTHOTECH CORP Protocol no: OPH1001. A Phase<br />
2, Randomized, Double-Masked, Controlled Trial to<br />
Establish the Safety and Efficacy <strong>of</strong> Intravitreous<br />
Injections <strong>of</strong> E10030 (Anti-PDGF Pegylated Aptamer)<br />
Given in Combination with Lucentis in Subjects with<br />
Neovascular Age-Related Macular Degeneration<br />
Principal Investigator: Michael S. Ip, MD<br />
Study Coordinator: Barbara H. Soderling<br />
Synopsis:<br />
The objectives <strong>of</strong> this study are to evaluate the<br />
safety and efficacy <strong>of</strong> E10030 intravitreous injection<br />
when administered in combination with Lucentis<br />
against a control <strong>of</strong> Lucentis alone in subjects with<br />
subfoveal choroidal neovascularization secondary<br />
to age-related macular degeneration (AMD).<br />
Evaluation <strong>of</strong> Possible Toxicity <strong>of</strong> Indocyanine<br />
Green Dye in Macular Hole Surgery Using<br />
Multifocal Electroretinogram<br />
Principal Investigator: Michael S. Ip, MD<br />
Student Researcher: Amol Kulkarni, MD<br />
Study Coordinator: Barbara H. Soderling<br />
Synopsis:<br />
The purpose <strong>of</strong> the research is to test the nerve cells<br />
in the retina by MERG to determine if there are any<br />
differences by using conventional (1 mg/ml) versus low<br />
dose (0.5 mg/ml) <strong>of</strong> ICG during macular hole surgery.<br />
Duration: This pilot study will last no longer than<br />
6-months for each subject. Recruitment will likely<br />
be complete within 8 months <strong>of</strong> study start date.<br />
The data analysis will be performed at the end<br />
<strong>of</strong> the study. It is expected that the study will be<br />
completed and the results will be available within<br />
18 months from the time <strong>of</strong> commencement.<br />
Outcome measures:<br />
Primary: Retinal response density as measured by mfERG at<br />
6-month post-operative visit to evaluate for retinal toxicity.<br />
Secondary: Best corrected snellen visual acuity<br />
(BCVA), and optical coherence tomography (OCT)<br />
evidence <strong>of</strong> hole closure in the operated eye.<br />
<strong>2010</strong> ANNUAL REPORT<br />
25
<strong>2010</strong> publications<br />
Aiello LP, Edwards AR, Beck RW, Bressler NM,<br />
Davis MD, Ferris F, Glassman AR, Ip MS, Miller<br />
KM. Factors associated with improvement and<br />
worsening <strong>of</strong> visual acuity 2 years after focal/<br />
grid photocoagulation for diabetic macular edema.<br />
Ophthalmology. <strong>2010</strong> May;117(5):946-53.<br />
Albert DM, Atzen SL, Morgan P. The practice <strong>of</strong><br />
ophthalmology in rural <strong>Wisconsin</strong> in the mid-19th<br />
century: from the casebooks <strong>of</strong> Francis Paddock,<br />
MD. Arch Ophthalmol. <strong>2010</strong> Jun;128(6):783-8.<br />
Albert DM, Neekhra A, Wang S, Darjatmoko SR,<br />
Sorenson CM, Dubielzig RR, Sheibani N. Development<br />
<strong>of</strong> choroidal neovascularization in rats with advanced<br />
intense cyclic light-induced retinal degeneration.<br />
Arch Ophthalmol. <strong>2010</strong> Feb;128(2):212-22.<br />
Altmann S, Emanuel A, Toomey M, McIntyre K,<br />
Covert J, Dubielzig RR, Leatherberry G, Murphy<br />
CJ, Kodihalli S, Brandt CR. A quantitative rabbit<br />
model <strong>of</strong> vaccinia keratitis. Invest Ophthalmol<br />
Vis Sci. <strong>2010</strong> Sep;51(9):4531-40.<br />
Altmann S, Toomey M, Nesbit B, McIntyre K,<br />
Covert J, Dubielzig RR, Leatherberry G, Adkins<br />
E, Murphy CJ, Brandt CR. Kinetics <strong>of</strong> immune<br />
cell infiltration in vaccinia virus keratitis. Invest<br />
Ophthalmol Vis Sci. <strong>2010</strong> Sep;51(9):4541-8.<br />
Ambrosius WT, Danis RP, G<strong>of</strong>f DC Jr, Greven CM,<br />
Gerstein HC, Cohen RM, Riddle MC, Miller ME, Buse JB,<br />
Bonds DE, Peterson KA, Rosenberg JD, Perdue LH, Esser<br />
BA, Seaquist LA, Felicetta JV, Chew EY; ACCORD Study<br />
Group. Lack <strong>of</strong> association between thiazolidinediones<br />
and macular edema in type 2 diabetes; the ACCORD eye<br />
substudy. Arch Ophthalmol. <strong>2010</strong> Mar;128(3):312-8.<br />
Blodi BA, Domalpally A, Scott IU, Ip MS, Oden NL,<br />
Elledge J, Warren K, Altaweel MM, Kim JE, Van<br />
Veldhuisen PC. Standard Care vs Corticosteroid for<br />
Retinal Vein Occlusion (SCORE) Study system for<br />
evaluation <strong>of</strong> stereoscopic color fundus photographs<br />
and fluorescein angiograms: SCORE Study <strong>Report</strong><br />
9. Arch Ophthalmol. <strong>2010</strong> Sep;128(9):1140-5.<br />
Boosani CS, Nalabothula N, Sheibani N, Sudhakar<br />
A. Inhibitory effects <strong>of</strong> arresten on bFGF-induced<br />
proliferation, migration, and matrix metalloproteinase-2<br />
activation in mouse retinal endothelial cells.<br />
Curr Eye Res. <strong>2010</strong> Jan;35(1):45-55.<br />
Bradfield Y. Vision screening to detect refractive<br />
error. JAMA. <strong>2010</strong> Sep 8; 304(10):1114-5.<br />
Buie LK, Rasmussen CA, Porterfield EC, Ramgolam<br />
VS, Choi VW, Markovic-Plese S, Samulski RJ,<br />
Kaufman PL, Borras T. Self-complementary AAV<br />
virus (scAAV) safe and long-term gene transfer in<br />
the trabecular meshwork <strong>of</strong> living rats and monkeys.<br />
Invest Ophthalmol Vis Sci. <strong>2010</strong> Jan;51(1):236-48.<br />
Bultmann H, Girdaukas G, Kwon GS, Brandt<br />
CR. The virucidal EB peptide protects host cells<br />
from herpes simplex virus type 1 infection in<br />
the presence <strong>of</strong> serum albumin and aggregates<br />
proteins in a detergent-like manner. Antimicrob<br />
Agents Chemother. <strong>2010</strong> Oct;54(10):4275-89.<br />
Candia OA, Kaufman PL. Remembering<br />
Steven M. Podos, MD, 1937-2009. Invest<br />
Ophthalmol Vis Sci. <strong>2010</strong> Mar;51(3):1261-2.<br />
Chen W, Stambolian D, Edwards AO, Branham KE, Othman<br />
M, Jakobsdottir J, Tosakulwong N, Pericak-Vance MA,<br />
Campochiaro PA, Klein ML, Tan PL, Conley YP, Kanda A,<br />
Kopplin L, Li Y, Augustaitis KJ, Karoukis AJ, Scott WK,<br />
Agarwal A, Kovach JL, Schwartz SG, Postel EA, Brooks M,<br />
Baratz KH, Brown WL, Brucker AJ, Orlin A, Brown G, Ho A,<br />
Regillo C, Donoso L, Tian L, Kaderli B, Hadley D, Hagstrom<br />
SA, Peachey NS, Klein R, Klein BE, Gotoh N, Yamashiro<br />
K, Ferris Iii F, Fagerness JA, Reynolds R, Farrer LA, Kim IK,<br />
Miller JW, Corton M, Carracedo A, Sanchez-Salorio M,<br />
Pugh EW, Doheny KF, Brion M, Deangelis MM, Weeks DE,<br />
Zack DJ, Chew EY, Heckenlively JR, Yoshimura N, Iyengar<br />
SK, Francis PJ, Katsanis N, Seddon JM, Haines JL, Gorin<br />
MB, Abecasis GR, Swaroop A. Genetic variants near TIMP3<br />
and high-density lipoprotein-associated loci influence<br />
susceptibility to age-related macular degeneration. Proc<br />
Natl Acad Sci U S A. <strong>2010</strong> Apr 20;107(16):7401-6.<br />
Cheng CY, Lee KE, Duggal P, Moore EL, Wilson AF, Klein<br />
R, Bailey-Wilson JE, Klein BE. Genome-wide linkage<br />
analysis <strong>of</strong> multiple metabolic factors: evidence <strong>of</strong> genetic<br />
heterogeneity. Obesity (Silver Spring) <strong>2010</strong> Jan;18(1):146-52.<br />
Cheng CY, Reich D, Wong TY, Klein R, Klein BE,<br />
Patterson N, Tandon A, Li M, Boerwinkle E, Sharrett<br />
AR, Kao WH. Admixture mapping scans identify a locus<br />
affecting retinal vascular caliber in hypertensive African<br />
Americans: the Atherosclerosis Risk in Communities<br />
(ARIC) study. PLoS Genet. <strong>2010</strong> Apr 15;6(4):e1000908.<br />
Chew EY, Ambrosius WT, Davis MD, Danis RP, Gangaputra<br />
S, Greven CM, Hubbard L, Esser BA, Lovato JF, Perdue<br />
LH, G<strong>of</strong>f DC, Jr., Cushman WC, Ginsberg HN, Elam MB,<br />
Genuth S, Gerstein HC, Schubart U, Fine LJ. Effects <strong>of</strong><br />
medical therapies on retinopathy progression in type 2<br />
diabetes. N Engl J Med. <strong>2010</strong> Jul 15;363(3):233-44.<br />
Chew EY, Kim J, Coleman HR, Aiello LP, Fish G, Ip M,<br />
Haller JA, Figueroa M, Martin D, Callanan D, Avery R,<br />
Hammel K, Thompson D, Ferris FL. Preliminary assessment<br />
<strong>of</strong> celecoxib and microdiode pulse laser treatment <strong>of</strong><br />
diabetic macular edema. Retina. <strong>2010</strong> Mar;30(3):459-67.<br />
Chew EY, Kim J, Sperduto RD, Datiles MB 3rd, Coleman<br />
HR, Thompson DJ, Milton RC, Clayton JA, Hubbard LD,<br />
Danis RP, Ferris FL 3rd. Evaluation <strong>of</strong> the age-related<br />
eye disease study clinical lens grading system AREDS<br />
report No. 31. Ophthalmology. <strong>2010</strong> Nov;117(11):2112-9.<br />
Danis RP, Scott IU, Qin H, Altaweel MM, Bressler<br />
NM, Bressler SB, Browning DJ, Kollman C. Association<br />
<strong>of</strong> fluorescein angiographic features with visual<br />
acuity and with optical coherence tomographic and<br />
stereoscopic color fundus photographic features<br />
<strong>of</strong> diabetic macular edema in a randomized clinical<br />
trial. Retina. <strong>2010</strong> Nov-Dec;30(10):1627-37.<br />
Diabetic Retinopathy Clinical Research Network<br />
Writing Committee, Haller JA, Qin H, Apte RS, Beck<br />
RR, Bressler NM, Browning DJ, Danis RP, Glassman<br />
AR, Googe JM, Kollman C, Lauer AK, Peters MA,<br />
Stockman ME. Vitrectomy outcomes in eyes with<br />
diabetic macular edema and vitreomacular traction.<br />
Ophthalmology. <strong>2010</strong> Jun;117(6):1087-1093.<br />
26<br />
UW DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES
Domalpally A, Danis RP, Myers D, Kruse CN.<br />
Quantitative analysis <strong>of</strong> the Stratus optical coherence<br />
tomography fast macular thickness map reports.<br />
Indian J Opthalmol. <strong>2010</strong> Mar-Apr;58(2):131-6.<br />
Domalpally A, Gangaputra S, Peng Q, Danis RP.<br />
Repeatability <strong>of</strong> retinal thickness measurements<br />
between spectral-domain and time-domain<br />
optical coherence tomography images in<br />
macular disease. Ophthalmic Surg Lasers<br />
Imaging. <strong>2010</strong> Nov-Dec;41 Suppl:S34-41.<br />
Dutta D, Ray S, Home P, Saha B, Wang S, Sheibani N,<br />
Tawfik O, Cheng N, Paul S. Regulation <strong>of</strong><br />
angiogenesis by histone chaperone HIRA-mediated<br />
incorporation <strong>of</strong> lysine 56-acetylated histone<br />
H3.3 at chromatin domains <strong>of</strong> endothelial genes.<br />
J Biol Chem. <strong>2010</strong> Dec 31;285(53):41567-77.<br />
France TD. Charlie Brown, amblyopia, and<br />
me: A (not so short) personal history <strong>of</strong> the<br />
past forty years <strong>of</strong> diagnosing and treating<br />
amblyopia. Am Orthopt J. <strong>2010</strong>;60:73-81.<br />
Fu YP, Hallman DM, Gonzalez VH, Klein BE, Klein R,<br />
Hayes MG, Cox NJ, Bell GI, Hanis CL. Identification<br />
<strong>of</strong> diabetic retinopathy genes through a genome-wide<br />
association study among Mexican-Americans from Starr<br />
County, Texas. J Ophthalmol. <strong>2010</strong>; <strong>2010</strong>. pii:86129<br />
Gamm DM, Meyer JS. Directed differentiation <strong>of</strong><br />
human induced pluripotent stem cells: a retina<br />
perspective. Regen Med. <strong>2010</strong> May; (3):315-7.<br />
Grutzmacher C, Park S, Elmergreen TL, Tang<br />
Y, Scheef EA, Sheibani N, Sorenson CM.<br />
Opposing effects <strong>of</strong> bim and bcl-2 on lung<br />
endothelial cell migration. Am J Physiol Lung<br />
Cell Mol Physiol. <strong>2010</strong> Nov;299(5):L607-20.<br />
Havas DA, Glenberg AM, Gutowski KA, Lucarelli<br />
MJ, Davidson RJ. (<strong>2010</strong>) Cosmetic use <strong>of</strong> botulinum<br />
toxin-a affects processing <strong>of</strong> emotional language.<br />
Psychol Sci. <strong>2010</strong> Jul; 21(7):895-900.<br />
Hwang FS, Neekhra A, Lucarelli MJ, Warner TF,<br />
Snow SN, Albert DM. Sebaceous cell carcinoma <strong>of</strong><br />
the eyelid: a rapidly enlarging lesion with massive<br />
xanthogranulomatous inflammation. Ophthal Plast<br />
Reconstr Surg. <strong>2010</strong> May-Jun;26(3):208-10.<br />
Ikram MK, Xueling S, Jensen RA, Cotch MF, Hewitt AW,<br />
Ikram MA, Wang JJ, Klein R, Klein BE, Breteler MM,<br />
Cheung N, Liew G, Mitchell P, Uitterlinden AG, Rivadeneira<br />
F, H<strong>of</strong>man A, de Jong PT, van Duijn CM, Kao L, Cheng<br />
CY, Smith AV, Glazer NL, Lumley T, McKnight B, Psaty<br />
BM, Jonasson F, Eiriksdottir G, Aspelund T, Harris TB,<br />
Launer LJ, Taylor KD, Li X, Iyengar SK, Xi Q, Sivakumaran<br />
TA, Mackey DA, Macgregor S, Martin NG, Young TL, Bis<br />
JC, Wiggins KL, Heckbert SR, Hammond CJ, Andrew T,<br />
Fahy S, Attia J, Holliday EG, Scott RJ, Islam FM, Rotter JI,<br />
McAuley AK, Boerwinkle E, Tai ES, Gudnason V, Siscovick<br />
DS, Vingerling JR, Wong TY. Four novel Loci (19q13,<br />
6q24, 12q24, and 5q14) influence the microcirculation<br />
in vivo. PLoS Genet. <strong>2010</strong> Oct 28;6(10):e1001184.<br />
Ip MS. What do I do when I see a patient with a branch<br />
retinal vein occlusion and what are the treatment<br />
options? In: Fekrat S, ed, Curbside Consultation in<br />
Retina. Slack Inc, Thor<strong>of</strong>are, NJ, pp.131-134, <strong>2010</strong>.<br />
Jensen K, Lee KE, Knudtson MD, Klein R, Klein<br />
BE. Stability <strong>of</strong> 35-mm scanners as used in<br />
ophthalmologic research. Ophthalmic Surg<br />
Lasers Imaging. <strong>2010</strong> Jan-Feb; 41(1):60-6.<br />
Jensen RA, Shea S, Ranjit N, Diez-Roux A, Wong<br />
TY, Klein R, Klein BE, Cotch MF, Siscovick DS.<br />
Psychosocial risk factors and retinal microvascular<br />
signs: the multi-ethnic study <strong>of</strong> atherosclerosis.<br />
Am J Epidemiol. <strong>2010</strong> Mar 1;171(5):522-31.<br />
Kaufman PL. Suppression and reduction <strong>of</strong> corticosteroidinduced<br />
ocular hypertension by anecortave in sheep.<br />
Arch Ophthalmol. <strong>2010</strong> Mar;128(3):365-6.<br />
Kempen JH, Altaweel MM, Holbrook JT, Jabs DA,<br />
Sugar EA. The multicenter uveitis steroid treatment<br />
trial: rationale, design, and baseline characteristics.<br />
Am J Ophthalmol. <strong>2010</strong> Apr;149(4):550-61 e10.<br />
Kern TS, Du Y, Miller CM, Hatala DA, Levin LA.<br />
Overexpression <strong>of</strong> Bcl-2 in vascular endothelium<br />
inhibits the microvascular lesions <strong>of</strong> diabetic<br />
retinopathy. Am J Pathol. <strong>2010</strong> May;176(5):2550-8.<br />
Klein BE, Lee KE, Danforth LG, Schaich TM,<br />
Cruickshanks KJ, Klein R. Selected sunsensitizing<br />
medications and incident cataract.<br />
Arch Ophthalmol. <strong>2010</strong> Aug;128(8):959-63.<br />
Klein BE, Lee KE, Moss SE, Trentham-Dietz A, Klein R.<br />
Self- and registry-reported cancer in a population-based<br />
longitudinal study. WMJ. <strong>2010</strong> Oct;109(5):261-6.<br />
Klein BE, Meuer SM, Lee KE, Klein R. Retrodots<br />
in the lens in the Beaver Dam Eye Study cohort.<br />
Ophthalmology. <strong>2010</strong> Oct;117(10):1889-93.<br />
Klein BE. Progression <strong>of</strong> retinopathy in persons<br />
with type 2 diabetes: new data, same conclusions?<br />
Pol Arch Med Wewn. <strong>2010</strong> Oct;120(10):413-6.<br />
Klein BE. Reduction in risk <strong>of</strong> progression <strong>of</strong> diabetic<br />
retinopathy. N Engl J Med. <strong>2010</strong> Jul 15;363(3):287-8.<br />
Klein R, Blodi BA, Meuer SM, Myers CE,<br />
Chew EY, Klein BE. The prevalence <strong>of</strong> macular<br />
telangiectasia type 2 in the Beaver Dam eye study.<br />
Am J Ophthalmol. <strong>2010</strong> Jul;150(1):55-62 e2.<br />
Klein R, Cruickshanks KJ, Nash SD, Krantz EM, Javier<br />
Nieto F, Huang GH, Pankow JS, Klein BE. The prevalence<br />
<strong>of</strong> age-related macular degeneration and associated risk<br />
factors. Arch Ophthalmol. <strong>2010</strong> Jun;128(6):750-8.<br />
Klein R, Klein BE. Are individuals with diabetes<br />
seeing better?: a long-term epidemiological<br />
perspective. Diabetes. <strong>2010</strong> Aug;59(8):1853-60.<br />
Klein R, Knudtson MD, Klein BE, Wong TY,<br />
Cotch MF, Barr G. Emphysema, airflow limitation,<br />
and early age-related macular degeneration.<br />
Arch Ophthalmol. <strong>2010</strong> Apr;128(4):472-7.<br />
<strong>2010</strong> ANNUAL REPORT<br />
27
<strong>2010</strong> publications<br />
Klein R, Knudtson MD, Klein BE, Zinman B,<br />
Gardiner R, Suissa S, Sinaiko AR, Donnelly SM,<br />
Goodyer P, Strand T, Mauer M. The relationship<br />
<strong>of</strong> retinal vessel diameter to changes in diabetic<br />
nephropathy structural variables in patients with type<br />
1 diabetes. Diabtologia. <strong>2010</strong> Aug;53(8):1638-46.<br />
Klein R, Lee KE, Gangnon RE, Klein BE. The 25-year<br />
incidence <strong>of</strong> visual impairment in type 1 diabetes<br />
mellitus: The <strong>Wisconsin</strong> epidemiologic study <strong>of</strong> diabetic<br />
retinopathy. Ophthalmology. <strong>2010</strong> Jan;117(1):63-70.<br />
Klein R, Myers CE, Klein BE, Zinman B, Gardiner<br />
R, Suissa S, Sinaiko AR, Donnelly SM, Goodyer P,<br />
Strand T, Mauer M. Relationship <strong>of</strong> blood pressure<br />
to retinal vessel diameter in type 1 diabetes mellitus.<br />
Arch Ophthalmol. <strong>2010</strong> Feb;128(2):198-205.<br />
Kopplin LJ, Igo RP, Jr., Wang Y, Sivakumaran TA,<br />
Hagstrom SA, Peachey NS, Francis PJ, Klein ML,<br />
Sangiovanni JP, Chew EY, Pauer GJ, Sturgill GM, Joshi<br />
T, Tian L, Xi Q, Henning AK, Lee KE, Klein R, Klein BE,<br />
Iyengar SK. Genome-wide association identifies SKIV2L<br />
and MYRIP as protective factors for age-related macular<br />
degeneration. Genes Immun. <strong>2010</strong> Dec; 11(8):609-21.<br />
Krantz EM, Cruickshanks KJ, Klein BE, Klein<br />
R, Huang GH, Nieto FJ. Measuring refraction<br />
in adults in epidemiological studies. Arch<br />
Ophthalmol. <strong>2010</strong> Jan;128(1):88-92.<br />
Kraus A, Groenendyk J, Bedard K, Baldwin<br />
TA, Krause KH, Dubois-Dauphin M, Dyck J,<br />
Rosenbaum EE, Korngut L, Colley NJ, Gosgnach<br />
S, Zochodne D, Todd K, Agellon LB, Michalak M.<br />
Calnexin deficiency leads to dysmyelination. J<br />
Biol Chem. <strong>2010</strong> Jun 11;285(24):18928-38.<br />
Kushner BJ. In memoriam: Arthur L. Rosenbaum, MD<br />
(1940-<strong>2010</strong>). Arch Ophthalmol. <strong>2010</strong> Oct;128(10):1383.<br />
Larsen IV, Brandt CR. A cationic TAT peptide<br />
Inhibits Herpes simplex virus type 1 Infection<br />
<strong>of</strong> human corneal epithelial cells. J Ocul<br />
Pharmacol Ther. <strong>2010</strong> Dec;26(6):541-7.<br />
Lee ES, Gabelt BT, Faralli JA, Peters DM, Brandt<br />
CR, Kaufman PL, Bhattacharya SK. COCH<br />
transgene expression in cultured human trabecular<br />
meshwork cells and its effect on outflow facility in<br />
monkey organ cultured anterior segments. Invest<br />
Ophthalmol Vis Sci. <strong>2010</strong> Apr;51(4):2060-6.<br />
Li HK, Florez-Arango JF, Hubbard LD, Esquivel<br />
A, Danis RP, Krupinski EA. Grading diabetic<br />
retinopathy severity from compressed digital retinal<br />
images compared with uncompressed images and<br />
film. Retina. <strong>2010</strong> Nov-Dec;30(10):1651-61.<br />
Li HK, Hubbard LD, Danis RP, Esquivel A, Florez-<br />
Arango JF, Ferrier NJ, Krupinski EA. Digital<br />
versus film Fundus photography for research<br />
grading <strong>of</strong> diabetic retinopathy severity. Invest.<br />
Ophthalmol Vis Sci. <strong>2010</strong> Nov;51(11):5846-52.<br />
Li HK, Hubbard LD, Danis RP, Esquivel A,<br />
Florez-Arango JF, Krupinski EA. Monoscopic<br />
versus stereoscopic retinal photography for<br />
grading diabetic retinopathy severity. Invest<br />
Ophthalmol Vis Sci. <strong>2010</strong> Jun;51(6):3184-92.<br />
Li HK, Hubbard LD, Danis RP, Florez-Arango JF,<br />
Esquivel A, Krupinski EA. Comparison <strong>of</strong> multiple<br />
stereoscopic and monoscopic digital image formats<br />
to film for diabetic macular edema evaluation. Invest<br />
Ophthalmol Vis Sci. <strong>2010</strong> Dec;51(12):6753-61.<br />
Lichtlen P, Lam TT, Nork TM, Streit T, Urech DM.<br />
Relative contribution <strong>of</strong> VEGF and TNF-alpha in the<br />
cynomolgus laser-induced CNV model: comparing the<br />
efficacy <strong>of</strong> bevacizumab, adalimumab, and ESBA105.<br />
Invest Ophthalmol Vis Sci. <strong>2010</strong> Sep;51(9):4738-45.<br />
Lu B, Wang S, Francis PJ, Li T, Gamm DM, Capowski<br />
EE, Lund RD. Cell transplantation to arrest<br />
early changes in an ush2a animal model. Invest<br />
Ophthalmol Vis Sci. <strong>2010</strong> Apr; 51(4):2269-76.<br />
Lutjen-Drecoll E, Kaufman PL, Wasielewski R, Ting-Li<br />
L, Cr<strong>of</strong>t MA. Morphology and accommodative function<br />
<strong>of</strong> the vitreous zonule in human and monkey eyes.<br />
Invest Ophthalmol Vis Sci. <strong>2010</strong> Mar;51(3):1554-64.<br />
Mares JA, Voland R, Adler R, Tinker L, Millen AE,<br />
Moeller SM, Blodi B, Gehrs KM, Wallace RB, Chappell<br />
RJ, Neuhouser ML, Sarto GE. Healthy diets and the<br />
subsequent prevalence <strong>of</strong> nuclear cataract in women.<br />
Arch Ophthalmol. <strong>2010</strong> Jun;128(6):738-49.<br />
Nema N, Ip MS. Intravitreal triamcinolone for<br />
management <strong>of</strong> idiopathic juxtafoveolar telangiectasis.<br />
Oman J Ophthalmol. <strong>2010</strong> Jan;3(1):38-40.<br />
Nguyen TT, Islam FM, Farouque HM, Klein R,<br />
Klein BE, Cotch MF, Herrington DM, Wong<br />
TY. Retinal vascular caliber and brachial flowmediated<br />
dilation: the Multi-Ethnic Study <strong>of</strong><br />
Atherosclerosis. Stroke. <strong>2010</strong> Jul;41(7):1343-8.<br />
Nickells RW. Variations in the rheostat model <strong>of</strong><br />
apoptosis: what studies <strong>of</strong> retinal ganglion cell<br />
death tell us about the functions <strong>of</strong> the Bcl2 family<br />
proteins. Exp Eye Res. <strong>2010</strong> Jul;91(1):2-8.<br />
Nondahl DM, Cruickshanks KJ, Wiley TL, Klein<br />
BE, Klein R, Chappell R, Tweed TS. The tenyear<br />
incidence <strong>of</strong> tinnitus among older adults.<br />
Int J Audiol. <strong>2010</strong> Aug;49(8):580-5.<br />
Nork TM, Kim CB, Heatley GA, Kaufman PL, Lucarelli<br />
MJ, Levin LA, Ver Hoeve JN. Serial multifocal<br />
electroretinograms during long-term elevation and<br />
reduction <strong>of</strong> intraocular pressure in non-human<br />
primates. Doc Ophthalmol. <strong>2010</strong> Jun;120(3):273-89.<br />
Oden NL, VanVeldhuisen PC, Scott IU, Ip MS; SCORE<br />
Study Investigator Group. SCORE Study <strong>Report</strong> 8:<br />
Closed tests for all pairwise comparisons <strong>of</strong> means.<br />
Drug Information Journal (DIA). <strong>2010</strong>;44:405-20.<br />
Pariseau B, Nehls S, Ogawa GS, Sutton DA, Wickes BL,<br />
Romanelli AM. Beauveria keratitis and biopesticides:<br />
case histories and a random amplification <strong>of</strong> polymorphic<br />
DNA comparison. Cornea <strong>2010</strong> Feb;29(2):152-8.<br />
Park S, Dimaio TA, Scheef EA, Sorenson CM,<br />
Sheibani N. PECAM-1 regulates the proangiogenic<br />
properties <strong>of</strong> endothelial cells through modulation<br />
<strong>of</strong> cell-cell and cell-matrix interactions. Am J Physiol<br />
Cell Physiol. <strong>2010</strong> Dec;299(6):C1468-84.<br />
28<br />
UW DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES
Pelzel HR, Schlamp CL, Nickells RW. Histone<br />
H4 deacetylation plays a critical role in early<br />
gene silencing during neuronal apoptosis.<br />
BMC neurosci. <strong>2010</strong> May 26;11:62.<br />
Puhan MA, Van Natta ML, Palella FJ, Addessi<br />
A, Meinert C. Excess mortality in patients with<br />
AIDS in the era <strong>of</strong> highly active antiretroviral<br />
therapy: temporal changes and risk factors.<br />
Clin Infect Dis. <strong>2010</strong> Oct 15;51(8):947-56.<br />
Recchia FM, Scott IU, Brown GC, Brown MM, Ho<br />
AC, Ip MS. Small-gauge pars plana vitrectomy: a<br />
report by the American Academy <strong>of</strong> Ophthalmology.<br />
Ophthalmology. <strong>2010</strong> Sep;117(9):1851-7.<br />
Sahakyan K, Klein BE, Lee KE, Tsai MY, Klein R.<br />
Inflammatory and endothelial dysfunction markers<br />
and proteinuria in persons with type 1 diabetes<br />
mellitus. Eur J Endocrinol. <strong>2010</strong> Jun;162(6):1101-5.<br />
Sahakyan K, Klein BE, Myers CE, Tsai MY, Klein R.<br />
Novel risk factors in long-term hypertension<br />
incidence in type 1 diabetes mellitus. Am.<br />
Heart J. <strong>2010</strong> Jun;159(6):1074-80.<br />
Schwinn MK, Gonzalez JM, Jr., Gabelt BT,<br />
Sheibani N, Kaufman PL, Peters DM. Heparin<br />
II domain <strong>of</strong> fibronectin mediates contractility<br />
through an alpha4beta1 co-signaling pathway.<br />
Exp Cell Res. <strong>2010</strong> May 15;316(9):1500-12.<br />
Scott CJ, Seidler EA, Levin LA. Cell-autonomous<br />
generation <strong>of</strong> mitochondrial superoxide is a signal<br />
for cell death in differentiated neuronal precursor<br />
cells. Brain Res. <strong>2010</strong> Jan 8;1306:142-8.<br />
Seidler EA, Lieven CJ, Thompson AF, Levin LA.<br />
Effectiveness <strong>of</strong> novel borane-phosphine<br />
complexes in inhibiting cell death depends on<br />
the source <strong>of</strong> superoxide production induced by<br />
blockade <strong>of</strong> mitochondrial electron transport.<br />
ACS Chem Neurosci. <strong>2010</strong> Feb 17;1(2):95-103.<br />
Semaan SJ, Li Y, Nickells RW. A single nucleotide<br />
polymorphism in the Bax gene promoter affects<br />
transcription and influences retinal ganglion cell<br />
death. ASN Neuro. <strong>2010</strong> Mar 31;2(2):e00032.<br />
Semaan SJ, Nickells RW. The apoptotic response in<br />
HCT116BAX-/- cancer cells becomes rapidly saturated<br />
with increasing expression <strong>of</strong> a GFP-BAX fusion<br />
protein. BMC Cancer. <strong>2010</strong> Oct 13;10(1):554.<br />
Shankar A, Lee KE, Klein BE, Muntner P, Brazy PC,<br />
Cruickshanks KJ, Nieto FJ, Danforth LG, Schubert<br />
CR, Tsai MY, Klein R. Estimating glomerular<br />
filtration rate in a population-based study. Vasc<br />
Health Risk Manag. <strong>2010</strong> Aug 9;6:619-27.<br />
Sharma A, Yu C, Leung C, Trane A, Lau M, Utokaparch<br />
S, Shaheen F, Sheibani N, Bernatchez P. A new role<br />
for the muscle repair protein dysferlin in endothelial<br />
cell adhesion and angiogenesis. Arterioscler<br />
Thromb Vasc Biol. <strong>2010</strong> Nov;30(11):2196-204.<br />
Sprague BL, Skinner HG, Trentham-Dietz A,<br />
Lee KE, Klein BE, Klein R. Serum calcium and<br />
breast cancer risk in a prospective cohort study.<br />
Ann Epidemiol. <strong>2010</strong> Jan;20(1):82-5.<br />
Struck MC, Hariharan L, Kushner BJ, Bradfield Y, Hetzel S.<br />
Surgical management <strong>of</strong> clinically significant hypertropia<br />
associated with exotropia. J AAPOS. Jun;14(3):216-20.<br />
Subramanian L, Youssef S, Bhattacharya S, Kenealey J,<br />
Polans AS, van Ginkel PR. Resveratrol: challenges<br />
in translation to the clinic - a critical discussion.<br />
Clin Cancer Res. <strong>2010</strong> Dec 15;16(24):5942-8.<br />
Talahalli R, Zarini S, Sheibani N, Murphy RC, Gubitosi-<br />
Klug RA. Increased synthesis <strong>of</strong> leukotrienes in<br />
the mouse model <strong>of</strong> diabetic retinopathy. Invest<br />
Ophthalmol Vis Sci. <strong>2010</strong> Mar;51(3):1699-708.<br />
Tan JC, Kiland JA, Gonzalez JM, Gabelt BT, Peters<br />
DM, Kaufman PL. Sodium orthovanadate effect<br />
on outflow facility and intraocular pressure in live<br />
monkeys. Exp Eye Res. <strong>2010</strong> Oct;91(4):486-90.<br />
Tang Y, Scheef EA, Gurel Z, Sorenson CM, Jefcoate<br />
CR, Sheibani N. CYP1B1 and endothelial nitric oxide<br />
synthase combine to sustain proangiogenic functions<br />
<strong>of</strong> endothelial cells under hyperoxic stress. Am J<br />
Physiol Cell Physiol. <strong>2010</strong> Mar;298(3):C665-78.<br />
Thompson AF, Levin LA. Neuronal differentiation<br />
by analogs <strong>of</strong> staurosporine. Neurochem<br />
Int. <strong>2010</strong> Mar; 56(4):554-60.<br />
Tian B, Heatley GA, Filla MS, Kaufman PL. Effect <strong>of</strong> h-7<br />
on secondary cataract after phacoemulsification in the live<br />
rabbit eye.J Ocul Pharmacol Ther. <strong>2010</strong> Dec;26(6):533-9.<br />
White NH, Sun W, Cleary PA, Tamborlane WV, Danis RP,<br />
Hainsworth DP, Davis MD. Effect <strong>of</strong> prior intensive<br />
therapy in type 1 diabetes on 10-year progression <strong>of</strong><br />
retinopathy in the DCCT/EDIC: comparison <strong>of</strong> adults<br />
and adolescents. Diabetes <strong>2010</strong> May;59(5):1244-53.<br />
Yan Y, Klein R, Heiss G, Girman CJ, Lange EM, Klein BE,<br />
Rose KM, Boerwinkle E, Pankow JS, Brancati FL,<br />
Ballantyne CM, Kottgen A, North KE. The transcription<br />
factor 7-like 2 (TCF7L2) polymorphism may be<br />
associated with focal arteriolar narrowing in Caucasians<br />
with hypertension or without diabetes: the ARIC<br />
Study. BMC Endocr Disord. <strong>2010</strong> May 17;10: 9.<br />
Yatsuya H, Folsom AR, Wong TY, Klein R, Klein BE,<br />
Sharrett AR. Retinal microvascular abnormalities<br />
and risk <strong>of</strong> lacunar stroke: Atherosclerosis Risk in<br />
Communities Study. Stroke. <strong>2010</strong> Jul;41(7):1349-55.<br />
Zhan W, Cruickshanks KJ, Klein BE, Klein R, Huang<br />
GH, Pankow JS, Gangnon RE, Tweed TS. Generational<br />
differences in the prevalence <strong>of</strong> hearing impairment in<br />
older adults. Am J Epidemiol. <strong>2010</strong> Jan 15;171(2):260-6.<br />
Zhang X, Saaddine JB, Chou CF, Cotch MF, Cheng YJ,<br />
Geiss LS, Gregg EW, Albright AL, Klein BE, Klein R.<br />
Prevalence <strong>of</strong> diabetic retinopathy in the United States,<br />
2005-2008. JAMA. <strong>2010</strong> Aug 11;304(6):649-56.<br />
Zhong W, Cruickshanks KJ, Schubert CR, Nieto FJ,<br />
Huang GH, Klein BE, Klein R. Obesity and depression<br />
symptoms in the Beaver Dam Offspring Study population.<br />
Depress Anxiety. <strong>2010</strong> Sep; 27(9):846-51.<br />
<strong>2010</strong> ANNUAL REPORT<br />
29
<strong>2010</strong> DONOR HONOR ROLL<br />
$100,000+<br />
Daniel M. and Eleanor Albert<br />
Retina Research Foundation<br />
<strong>University</strong> <strong>of</strong> WI Medical Fdtn<br />
$10,000-99,999<br />
Nancy Chow<br />
Sarah E. Slack Prevention<br />
<strong>of</strong> Blindness<br />
$5,000-9,999<br />
Covance Laboratories<br />
North America<br />
OSOD LLC<br />
$1,000-4,999<br />
James C. Allen<br />
Charles J. Chvala<br />
Matthew D. Davis<br />
David E. Grosz<br />
Wendell A. Harker<br />
Newell D. and Helen Jasperson<br />
Albert V. and Dolores H. Kanner<br />
Irving E. Levy<br />
Jeffrey C. Levy<br />
Ronald L. and Jean L. Lewis<br />
Mark F. Mergen<br />
T. Michael Nork<br />
Mary V. H. Pratt<br />
Wanda L. Rood<br />
Isolde Schwegler<br />
Bryan S. Sires<br />
Casmir Turnquist-Held<br />
Amy L. Walker<br />
Lucille M. Warren<br />
Robert G. and Carol A. Witt<br />
Audrey A. Yahr<br />
$500-999<br />
Robert V. Castrovinci<br />
and Kay E. Rutlin<br />
Michelle E. Chizek<br />
Gregg A. Heatley<br />
Michael J. Long<br />
David P. and Cathrine Mc Cann<br />
Merle L. and Barbara Perkins<br />
Harry and Karen M. Roth<br />
Gregory A. Stainer<br />
Robin S. Wilson<br />
Wittenberg Lions Club<br />
VOLUNTEER & AFFILIATE<br />
FACULTY MEmbers<br />
<strong>2010</strong> FINANCIAL<br />
HIGHLIGHTS<br />
Charles J. Anderson, MD<br />
Michele A. Basso, PhD - Affiliate<br />
Donald E. Beresky, MD<br />
Stephen M. Boorstein, MD<br />
Christopher R. Croasdale, MD<br />
George E. Davis, MD<br />
Thomas C. Dow, MD<br />
Richard R. Dubielzig, DVM - Affiliate<br />
Daniel R.B. Fary, MD<br />
Judith E. FitzGerald, MD<br />
Russell S. Gonnering, MD<br />
Anne E. Griep, PhD - Affiliate<br />
Kara H. Harbick, MD<br />
Rachael S. Horn, MD<br />
Jeffrey W. Kalenak, MD<br />
Bradley N. Lemke, MD<br />
Bruce M. Massaro, MD<br />
Peter J. McCanna, MD<br />
Kevin B. Miller, MD<br />
Mansoor M. Movaghar, MD<br />
Christopher J. Murphy, DVM, PhD<br />
- Affiliate<br />
Earl W. Nepple, MD<br />
Bikash Pattnaik, PhD - Affiliate<br />
Donna M. Peters, PhD - Affiliate<br />
John G. Rose, Jr., MD<br />
Harry Roth, MD<br />
Kurt A. Schwiesow, MD<br />
Michael H. Scott, MD<br />
Morton E. Smith, MD<br />
Robert G. Smith, MD<br />
Stephen J. Sramek, MD<br />
Rodney J. Sturm, MD<br />
Michael P. Vrabec, MD<br />
John A. Vukich, MD<br />
Mitchell D. Wolf, MD<br />
Tien Yin Wong, PhD<br />
Peter N. Youssef, MD<br />
1<br />
2<br />
3<br />
PRIVATE GIFTS<br />
& DONATIONS<br />
UWMF CLINICAL<br />
CONTRIBUTIONS<br />
FOR R&D<br />
RESEARCH GRANTS<br />
& AWARDS<br />
$ 281,235<br />
$ 1,218,307<br />
$ 14,563,883<br />
4 CLINICAL TRIALS $ 310,990<br />
5 HOSPITAL SUPPORT $ 493,034<br />
6 PRACTICE PLAN $ 23,698,867<br />
7<br />
8<br />
MEDICAL SCHOOL<br />
FACULTY SUPPORT $ 1,172,089<br />
RESEARCH FEE-<br />
FOR-SERVICE<br />
AGREEMENTS<br />
$ 7,316,736<br />
<strong>2010</strong> ANNUAL REPORT<br />
31
This <strong>2010</strong> <strong>Annual</strong> <strong>Report</strong> was produced by the <strong>University</strong> <strong>of</strong> <strong>Wisconsin</strong> <strong>Department</strong> <strong>of</strong> Ophthalmology and<br />
Visual Sciences for referring physicians, doctors, donors, alumni and friends <strong>of</strong> the department.<br />
To have your name removed from the <strong>Annual</strong> <strong>Report</strong> mailing list or to have your address changed, please call:<br />
Amy Zimmerman at (608) 263-1480.<br />
Or send your request to:<br />
UW <strong>Department</strong> <strong>of</strong> Ophthalmology<br />
and Visual Sciences<br />
Attn: Amy Zimmerman<br />
2828 Marshall Court, Suite 106<br />
Madison, WI 53705<br />
UNIVERSITY OF WISCONSIN<br />
DEPARTMENT OF<br />
OPHTHALMOLOGY<br />
AND VISUAL SCIENCES<br />
2828 Marshall Court, Suite 200<br />
Madison, WI 53705<br />
CHAIR<br />
Paul L. Kaufman, MD<br />
UW <strong>Department</strong> <strong>of</strong> Ophthalmology<br />
and Visual Sciences<br />
2828 Marshall Court, Suite 200<br />
Madison, WI 53705<br />
608-263-6070<br />
608-263-1466 fax<br />
EDITOR<br />
Sarah M. Fuelleman<br />
UW <strong>Department</strong> <strong>of</strong> Ophthalmology<br />
and Visual Sciences<br />
2828 Marshall Court, Suite 200<br />
Madison, WI 53705<br />
608-262-3953<br />
608-262-2212 fax<br />
sfuelleman@ophth.wisc.edu<br />
ANNUAL REPORT<br />
EDITORIAL COMMITTEE<br />
Barbara A. Blodi, MD<br />
Yasmin S. Bradfield, MD<br />
Michelle E. Chizek, MBA<br />
Paul L. Kaufman, MD<br />
Jill Cohen Kolb, MA<br />
Robert W. Nickells, PhD<br />
Christopher C. Temme<br />
DESIGN & PRODUCTION<br />
Greenleaf Media<br />
PHOTOGRAPHY<br />
Andy Manis Photo<br />
To contribute to the UW <strong>Department</strong><br />
<strong>of</strong> Ophthalmology and Visual<br />
Sciences, please contact:<br />
Steve Ramig, Jr.<br />
Director <strong>of</strong> Development<br />
<strong>University</strong> <strong>of</strong> <strong>Wisconsin</strong> Foundation<br />
1848 <strong>University</strong> Avenue<br />
P.O. Box 8860<br />
Madison WI 53708-8860<br />
608-265-3527<br />
steve.ramig@supportuw.org
MISSION<br />
STATEMENT<br />
To create, integrate, transmit and apply<br />
knowledge in ophthalmology and visual sciences.<br />
To provide high-quality comprehensive and tertiary<br />
eye care for the university health center, the<br />
Madison community, and the surrounding region<br />
in an efficient and cost-effective manner; and in<br />
select areas to serve as a resource for the nation.<br />
To facilitate multidisciplinary research and<br />
scientific development by fostering research<br />
collaboration and mutual learning, and to play a<br />
leading role in research, teaching and collaborative<br />
studies related to the visual sciences.<br />
To educate medical students, ophthalmologistsin-training<br />
(residents and fellows), practicing<br />
ophthalmologists, researchers in visual<br />
sciences and related disciplines, nonophthalmology<br />
physicians, non-ophthalmology<br />
health care providers and the public.