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Clinical Guidelines for the use of Palliative Care Drugs in Renal ...

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<strong>Cl<strong>in</strong>ical</strong> <strong>Guidel<strong>in</strong>es</strong> <strong>for</strong> In<strong>for</strong>mation is from <strong>in</strong>dividual data sheets, except, <strong>in</strong> blue = <strong>Renal</strong> Drug Handbook 2 nd<br />

PALLIATIVE CARE DRUGS IN RENAL FAILURE Edition, <strong>in</strong> p<strong>in</strong>k = <strong>Renal</strong> Drug Handbook – Draft 3 rd edition and <strong>in</strong> green = Micromedex.<br />

All o<strong>the</strong>r references are specified.<br />

DRUG<br />

Ibupr<strong>of</strong>en<br />

Ketam<strong>in</strong>e<br />

Ketorolac<br />

Lactulose<br />

METABOLITES<br />

(A=active,<br />

I=<strong>in</strong>active)<br />

Liver metabolism to<br />

<strong>in</strong>active conjugates (I)<br />

Nor-ketam<strong>in</strong>e (A)<br />

dehydronor-ketam<strong>in</strong>e<br />

(I)<br />

Hydroxylated <strong>in</strong>to<br />

<strong>in</strong>active metabolite (I)<br />

Lactic acid (A)<br />

Formic acid (A)<br />

Acetic acid (A)<br />

ELIMINATION<br />

(D=drug,<br />

M=metabolites)<br />

<strong>Renal</strong><br />

D

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