SEE INSIDE - Pittsburgh Tissue Engineering Initiative

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Cardiovascular III Orthopedic III Neural I Facts and Theories of
Organ Regeneration
Robert Nerem, PhD
Georgia Institute of Technology
William Wagner, PhD
McGowan Institute for Regenerative Medicine
Aaron Goldstein, PhD
Virginia Polytechnic Institute and State University
Gilson Khang, PhD
Chonbuk National University
Shelly Sakiyama-Elbert, PhD
Washington University
Hideyuki Okano, MD, PhD
Keio University, School of Medicine
Ioannis Yannas, PhD
Massachusetts Institute of Technology
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DESCRIPTION
Cardiovascular sessions broadly focus on
regenerative medicine approaches to cardiovascular
disease, including tissue engineering,
cell therapies, and devices.
Regenerating or replacing connective
tissues that serve a significant biomechanical
function has proven exception -
ally challenging. These sessions provide
an update on the latest advances
towards restoring function to both hard
and soft musculoskeletal tissues damaged
due to injury or disease.
In these sessions, broad topics on the
regeneration of nervous system are cov -
ered including the basic biology of neural
stem cells in fetal and adult stages, axonal
regeneration, tissue engineering and cell
therapies for damaged brain and spinal
cord, PNS and CNS regeneration and neu -
ral crest cells. Half of the speakers are
invited and the remaining half of them are
from submitted abstracts.
The session on Facts and Theories of
Organ Regeneration focuses on the
emerging theoretical underpinnings of
regenerative medicine. Theories of the
transition from early fetal to late fetal
healing are contrasted with those culled
from the practice of organ regeneration
in adults. The material presented in this
session should be helpful in developing
sound strategies for inducing organ
regeneration in adult mammals.
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Cardiovascular IV Oral/Dental/Craniofacial Neural II Skin/Wound Healing
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Robert Nerem, PhD
Georgia Institute of Technology
William Wagner, PhD
McGowan Institute for Regenerative Medicine
Jeremy Mao, DDS, PhD
University of Illionois at Chicago
Pamela Yelick, PhD
The Forsyth Institute
Shelly Sakiyama-Elbert, PhD
Washington University
Hideyuki Okano, MD, PhD
Keio University, School of Medicine
Adam Katz, MD
University of Virginia Health System
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DESCRIPTION
Cardiovascular sessions broadly focus on
regenerative medicine approaches to car -
diovascular disease, including tissue engineering,
cell therapies, and devices.
The field of tissue engineering for dental
and craniofacial applications is rapidly
evolving. Success in this effort is
dependent on advances in biomaterials
fabrication and design, progenitor cell
characterization, and localized gene and
protein delivery techniques. This session
includes presentations of some state of
the art techniques currently being developed
for the repair and regeneration of
dental and orofacial tissues.
In these sessions, broad topics on the
regeneration of nervous system are cov -
ered including the basic biology of neural
stem cells in fetal and adult stages, axonal
regeneration, tissue engineering and cell
therapies for damaged brain and spinal
cord, PNS and CNS regeneration and neural
crest cells. Half of the speakers are
invited and the remaining half of them are
from submitted abstracts.
Complicated wounds and chronic skin
ulcers remain a significant clinical challenge
despite concerted efforts toward
their prevention and treatment. This
session highlights emerging ideas and
innovative strategies aimed to address
challenges of impaired healing, chronic
wounds and skin/soft tissue reconstruction/regeneration.
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WEDNESDAY - APRIL 26
8:30 a.m.
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Panel - Tissue Engineering Centers from around the World: An Overview
Organizer: Michael Lysaght, PhD and Robert Nerem, PhD
Cell Sourcing I Linking Pre-Clinical & Clinical Studies Cell Targeting
Nancy Dock, PhD
Cambrex Bio Science
David Williams, PhD
UK Centre for Tissue Engineering
Kevin Shakesheff, PhD
University of Nottingham
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DESCRIPTION
Presentations will include novel models for cell
manipulation including mechanical stimulation
and transfection. Chemical means to induce differentiation
and de-differentiation will be discussed.
Optimization of methods for isolation and induction
of cells for research and clinical application
will be presented.
After some 15 to 20 years of experimental work, and 10
years of very limited clinical experiences, the field of
regenerative medicine is just now gearing up to translate
the experiences so far gained into major clinical studies
and trials. However, the regulatory environment has not
been sufficiently well developed to allow for this to be
achieved with confidence. The nature of the essential
pre-clinical studies that should be required for approval
to start clinical trials has not been determined. This session
will address the interface between pre-clinical and
clinical studies.
A major barrier to successful clinical implementation of
regenerative medicine is the challenge of delivering cells
and other therapeutic agents to the precise site of tissue
repair. Accurate delivery of cells within the body requires
new approaches to the development of injectable biomaterials
that can protect cells, provide the initial regenerative
environment, promote angiogenesis and withstand
mechanical forces exerted by surrounding tissues. Matrixassisted
cell delivery is making a clinical impact in a number
of applications and the need for more complex delivery
systems for stem cells for use in the brain, nervous system,
liver, heart and many other tissues is driving the academic
and commercial development of this area.
SELL-OUT CROWD EXPECTED! Register today at www.regenerate-online.com or call 412-235-5116