Toxicological Review of n-Hexane (CAS No. 110-54-3) (PDF)

Table 4-9. Relative organ weights of male Sprague-Dawley rats exposed to n-hexane 22
hours/day, 7 days/week for 6 months .......................................54
Table 4-10. Incidence of nasal turbinate and neuropathological lesions in B6C3F1 mice exposed
to n-hexane for 13 weeks .................................................56
Table 4-11. Skeletal variations in live fetuses of pregnant Sprague-Dawley rats exposed to n-
hexane via inhalation ....................................................60
Table 4-12. Total red blood cells and nucleated cells in bronchial lavage from n-hexane-
challenged New Zealand white rabbits ......................................63
Table 4-13. Enzyme activities in lung homogenates of rabbits exposed to n-hexane ........ 64
Table 4-14. Concentration of biochemicals and enzyme activities in bronchial lavage fluid from
male Sprague-Dawley rats exposed to n-hexane ...............................64
Table 4-15. Changes in sciatic and sural nerve action potentials induced by n-hexane and 2,5­
hexanedione ...........................................................67
Table 4-16. Incidence of liver and pituitary tumors in male and female B6C3F1 mice exposed to
commercial hexane for 2 years ............................................70
Table 4-17. Time-to-onset for the appearance of axonal swelling in explanted cultures of fetal
mouse spinal cord incubated with mixtures of n-hexane and methyl ethyl ketone ..... 76
Table 4-18. Effect of 2,5-hexanedione, acetone, ethanol, and mixtures of 2,5-hexanedione with
acetone or ethanol in drinking water on average MCV . .........................79
Table 4-19. Pyrrole adduct formation in proteins from (-diketone-treated rats ............. 87
Table 4-20. Summary of in vitro assays on the mutagenicity/genotoxicity of n-hexane ...... 90
Table 4-21. Summary of in vivo assays on the mutagenicity/genotoxicity of n-hexane ...... 91
Table 4-22. Summary of in vivo and in vitro assays on the mutagenicity/ genotoxicity of
commercial hexane mixtures ..............................................92
Table 4-23. Toxicity findings in inhalation studies for n-hexane . ...................... 101
Table 5-1. BMD results of n-hexane inhalation toxicity studies for selection of the principal
study ................................................................118
Table B-1. Mean nerve conduction velocity in rats exposed to n-hexane ................ B-3
vi