Using R For Flexible Modelling Of Pre-Clinical Combination Studies
Using R For Flexible Modelling Of Pre-Clinical Combination Studies
Using R For Flexible Modelling Of Pre-Clinical Combination Studies
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Interaction Index – Berenbaum<br />
<strong>Combination</strong> Index – Chou & Talalay<br />
IC70<br />
IC50<br />
IC30<br />
τ<br />
τ<br />
d +<br />
d<br />
τ =<br />
A B<br />
DA<br />
DB<br />
= fraction of expected dose,<br />
assuming additivity, required to have<br />
same effect<br />
IC30 IC50 IC70<br />
AstraZeneca Discovery Statistics<br />
8 Chris Harbron, <strong>Using</strong> R <strong>For</strong> <strong>Flexible</strong> <strong>Modelling</strong> <strong>Of</strong> <strong>Pre</strong>-<strong>Clinical</strong> <strong>Combination</strong> <strong>Studies</strong>, USE-R 2009
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