viding more specific cutting scores and likelihood ratios is warranted. References: Ben-Porath YS & Tellegen A. (2008) Minnesota Multiphasic Personality Inventory-2 Restructed Form. Manual for Administration, Scoring, and Interpretation. Minneapolis, MN: University <strong>of</strong> Minnesota Press Cragar, DE, Schmitt, FA, Berry, DTR, Cibula, JE, Dearth, CMS, & Fakhoury, TA.(2003). Comparison <strong>of</strong> MMPI-2 decision rules in the diagnosis <strong>of</strong> non-epileptic seizures. Journal <strong>of</strong> Clinical and Experimental Neuropsychology, 25, 793-804. 18. Serotonin Transporter Gene X Child Abuse History Interaction Associated with Physiological and Metabolic Characteristics <strong>of</strong> Caucasian Female Depressed Psychiatric Inpatients Presenting Author: Gen Shinozaki, MD Co-Authors: Magdalena Romanowicz, MD, Simon Kung, MD, James Rundell, MD, FAPM, David Mrazek, MD Purpose: Child abuse history and serotonin transporter gene promoter polymorphism (5HTTLPR) are known to interact with the probability <strong>of</strong> depression (1). Previously we reported that the psychiatric characteristics <strong>of</strong> depressed inpatients are also influenced by this interaction, although those with the homozygous long allele (l/l) showed higher rate <strong>of</strong> suicide attempt, contrary to our prediction (2). Also, psychosocial factors have been associated with a synergistic relationship between depression and metabolic syndrome (3). We extended our investigation about the impact <strong>of</strong> gene x environment interaction upon other characteristics <strong>of</strong> depressed psychiatric inpatients including their medical comorbidities as well as physiological and metabolic pr<strong>of</strong>iles. Methods: Retrospective chart review was conducted <strong>of</strong> 185 Caucasian female patients hospitalized for depression on the Mayo Clinic Mood Disorders Unit from 2005-2007 and genotyped for 5HTTLPR. We focused on this population in order to avoid the ethnic stratification and to avoid gender differences in physiological and metabolic pr<strong>of</strong>iles. Patients’ medical characteristics were recorded including resting heart rate on admission, body mass index (BMI), fasting glucose test result, past medical history and current medications. The subjects were divided into 2 groups (the l/l genotype group and others: the s/s and s/l genotype). Each genotype group was further divided into two sub-groups based on the history <strong>of</strong> child abuse for statistical analysis, and for each characteristic, Fisher’s Exact Tests were used to analyze categorical data. T-tests were used for continuous data. Results: 87 patients (47.0%) had no history <strong>of</strong> child abuse, and 98 (53.0%) had abuse history (sexual, physical, or emotional). We found that, among patients with the l/l genotype, patients with abuse history had a higher average heart rate on admission (83.2 bpm versus 73.6 bpm, p=0.013), higher prevalence <strong>of</strong> diabetes (14.3% versus 0%, p=0.06), and higher BMI (32.3kg/m2 versus 27.3kg/m2, p=0.03) than patients without abuse history. Patients with the short allele (s/s 8 or s/l) did not have significant differences based on abuse history. Conclusions. Among Caucasian female depressed psychiatric inpatients, if abused, l/l/ genotype patients showed (a) significant association with 10 bpm faster resting heart rate, (b) trend toward higher prevalence <strong>of</strong> diabetes, and (c) significant increase <strong>of</strong> BMI into obesity range compared to non abused group. Contrary to the widely recognized “reactivity” associated with the short allele <strong>of</strong> 5HTTLPR, our Caucasian female depressed psychiatric inpatients with the l/l genotype showed distinct clinical pathology when compared with other 5HTTLPR genotype groups with history <strong>of</strong> child abuse. References. 1. Caspi A, Sugden K, M<strong>of</strong>fitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R. Influence <strong>of</strong> life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301:386- 389. 2. Shinozaki G, Passov V, Romanowicz M, Kung S, Alarcon R, Mrazek D: “Gene x Environment Interaction: the serotonin transporter gene polymorphism and abuse history influencing the characteristics <strong>of</strong> depressed inpatients”, American Psychiatric Association, Annual Meeting, May 16-21, 2009, San Francisco CA 3. Räikkönen K, Matthews KA, Kuller LH. Depressive symptoms and stressful life events predict metabolic syndrome among middle-aged women: a comparison <strong>of</strong> World Health Organization, Adult Treatment Panel III, and International Diabetes Foundation definitions. Diabetes Care. 2007 Apr;30(4):872-7. 19. Anxious, Introverted Personality Traits in Chronic Subjective Dizziness Presenting Author: Jeffrey Staab, MD Co-Authors: Daniel Rohe, PhD, Scott Eggers, MD, Neil Shepard, PhD Purpose: Chronic subjective dizziness (CSD) is a common psychosomatic syndrome <strong>of</strong> persistent dizziness or subjective imbalance accompanied by hypersensitivity to motion stimuli in the absence <strong>of</strong> active vestibular illness. CSD is triggered by medical or psychiatric events that cause transient dizziness and may be sustained by fear-conditioned hypersensitivity to motion cues. This study tested the hypothesis that patients with CSD have more anxious or introverted personality traits than those with other types <strong>of</strong> chronic dizziness. Methods: Forty patients referred to a tertiary neurotology clinic for persistent dizziness were included because they screened positive for anxiety or depression on the Hospital Anxiety and Depression Scale (HADS) or because their symptoms could not be explained fully by an active neurotologic condition. Twenty-four were diagnosed with CSD. Sixteen had other, comorbid medical-psychiatric illnesses, such as Ménière’s disease plus generalized anxiety disorder. Temperament was measured with the NEO-PI-R. Between group analyses tested differences in age, sex, HADS scores,
and DSM-IV diagnoses, as well as mean scores and percentages <strong>of</strong> high/low scores on NEO-PI-R factors and facets. Logistical regression identified predictors <strong>of</strong> CSD. From these results, a composite temperament <strong>of</strong> CSD was identified and compared between groups. Results: CSD and comparison groups did not differ in age, sex, HADS scores, or DSM-IV diagnoses. The CSD group was more introverted and affectively restricted with significantly lower mean scores on the extraversion (E) factor and openness to feelings (O3) facet (p
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