David R. Busch Jr. - School of Arts & Sciences - University of ...

David Richard Busch Jr.
Dept. Physics, 209 S. 33rd St., Philadelphia PA 19104. 215-821-7175
david.r.busch@physics.upenn.edu
http://www.sas.upenn.edu/∼drbusch
Education and Training
University of Pennsylvania
Philadelphia, PA
Doctor of Philosophy and Masters of Science, Physics Ph.D. degree expected Dec. 2011
Thesis: Computer-Aided, Multi-Modal, and Compression Diffuse Optical Studies of Breast Tissue.
(Development and application of a novel computer-aided diagnostic algorithm, combined diffuse optical and magnetic
resonance imaging, and measurements of micro-vascular blood flow in healthy and cancerous human breast tissue.)
St. John’s University
Collegeville, MN
Bachelor of Arts with Distinction in Physics and All College Honors, cum laude 2001
Minors: Mathematics and Philosophy Dean’s List, 1997-2001 Regent’s and Siehl Memorial Scholarships, 1997-2001
Experience
Business Positions
Consultant Detroit, MI 2010-Present
Angott Medical Products
Diffuse Optical Spectroscopy component of ‘AMP Triple Test’
• Worked with CEO and executive team to introduce unfamiliar technology, evaluate commercial viability of product,
and explore potential technological challenges to clinical utility.
• Assisted in development and implementation of strategic plan for product research and development.
• Advised engineering team with detailed knowledge of the field, regulatory compliance, and creation of prototype.
• Project output: product development and prototype evaluation are currently ongoing.
Managing Partner Philadelphia, PA 2004-Present
5034Properties, LLC.
Real Estate Rental and Management
• Renovation of early 1900’s Victorian twin, management of rental units, and maintenance.
• Project output: Positive cash flow, increased equity, improved physical condition of property.
Academic Positions
Post Doctoral Researcher Philadelphia, PA Sept. 2011-Present
Prof. Arjun G. Yodh
Dept. of Physics, University of Pennsylvania
• Projects currently recruiting additional subjects prior to publication:
– Optical measurements of micro-vascular blood flow changes during mammographic compression.
– Simultaneous magnetic resonance and diffuse optical imaging of contrast agent uptake in breast cancer.
• Responsible for equipment budget (>$350k), multi-disciplinary research, ongoing mentorship of one undergraduate
and two graduate students, assisting in grant applications, and exploration of new research opportunities.
• Current project output: one new collaboration, expanded two existing collaborations, and clinical data collection.
Research Assistant Philadelphia, PA 2002-2011
Prof. Arjun G. Yodh
Dept. of Physics University of Pennsylvania
Primarily responsible for multi-disciplinary, multi-department project from components to clinical studies over seven years,
in collaboration with Prof. Britton Chance, Dept. of Biochemistry and Molecular Biophysics and Prof. Mitchel D. Schnall
and Mark A. Rosen, Dept. of Radiology University of Pennsylvania.
• Formally and informally mentored more than ten undergraduate and three graduate students; supervised three
technicians during instrument development, human subject data collection, and regulatory compliance.
• Assisted in preparation and writing of three R01 (two funded), three P41 (funded), and three R21 NIH grant
submissions. Prepared and submitted two DOD fellowship applications. Obtained multiple individual travel grants.
• Evaluated, purchased, and integrated >$300k worth of opto-electronic components.
• Project output: multi-modal imaging platform deployed to Radiology clinic for human tests, more than 30 subjects
imaged with multi-modality contrast enhanced system, more than two dozen conference presentations, and one each
first author and secondary author peer-reviewed papers (two additional first author papers are in preparation).
David R. Busch Resume pg. 1

Skills
Quantitative Data Reduction and Analysis
Statistical analysis and parametrization of large and complex data sets to extract metrics for clinical diagnosis. Analysis of
noisy and incomplete experimental data from small populations. Visual representation of multi-parameter data.
Scientific and High Technology Instrument Design, Construction, and Control
Opto-Electronics, high field magnets, medical imaging and monitoring, computers, data processing, health care databases.
Academic Background
Physics, Applied Mathematics, and Optics (graduate level); Chemistry and Biology (intermediate college level, advanced
knowledge in specific fields); Philosophy (undergraduate minor); Medical Imaging (esp. breast cancer and brain).
Computer Software and Administration
Data Analysis: Matlab, Mathematica, Office Productivity Suites, Server and Workstation Administration, Scripting.
Professional Activities and Recognition
Awards and Honors
John R. Cameron Young Investigator Award 2010
American Association of Physicists in Medicine
3rd place
Best Student Poster 2008
Optical Society of America
Biomedical Optics Topical Meeting
National Merit Scholarship 1997
Visiting Researcher
Physikalisch-Technische Bundesanstalt (Medical Physics and Metrological Information Technology, Berlin, Germany).
Presentations
Five invited and more than seventeen other scientific presentations at national and international conferences.
Publications
Peer-Reviewed Publications
Computer aided automatic detection of malignant lesions in diffuse optical mammography. Med-
Phys, 2010. D. R. Busch, W. Guo, R. Choe, T. Durduran, M. D. Feldman, C. Mies, M. A. Rosen, M. D. Schnall,
B. J. Czerniecki, J. Tchou, A. DeMichele, M. E. Putt, and A. G. Yodh.
Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate
diffuse optical tomography. JBO., 2009. R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch,
B. J. Czerniecki, J. Tchou, D. L. Fraker, A. DeMichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver,
M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh.
Determination of the optical properties of two-layer turbid media using a frequency domain hybrid
Monte Carlo-diffusion model. A.O., 2000. G. Alexandrakis, D. R. Busch, G.W. Faris, and M.S. Patterson.
First Author Manuscripts in Preparation
Simultaneous contrast enhanced diffuse optical and magnetic resonance imaging of breast cancer.
Hemodynamic changes during simulated mammography.
Contributing author on three additional manuscripts currently in preparation.
Other Activities
Volunteer Work Scouting: Assistant Scoutmaster, Merit Badge Counselor, Eagle Scout (gold palm). Emergency Medical
Technician: St. John’s EMT Squad, University of Minnesota EM Services Team. Clubs University of Pennsylvania and St.
John’s Taekwondo Clubs (black belt), Twin Cities Fencing Club (Junior Olympics, foil and epee), Order of the Arrow
(Brotherhood), JROTC (Cadet Captain). Hobbies Backpacking, Medium Format Photography (published, exhibited, and
sold; photographic accessory design- one commercialized), and Home Brewing.
David R. Busch Resume pg. 2