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16 Session 1: Acute Myelogenous Leukemia - CRI patients: Application to a clinical trial of AMSA for acute leukemia. J Clin Oncol 1987; 5: 710-721. 4. Preisler HD, Raza A, Early A, Kirshner J, Brecher M, Freeman A, et al. Intensive remission consolidation therapy in the treatment of acute nonlymphocytic leukemia. J Clin Oncol 1987; 5: 722-730. 5. Spinolo JA, Dicke KA, Horwitz Ii, Jagannath S, Zander AR, Auber ML and Spitzer G. Double intensification with amsacrine/high dose ara-C and high dose chemotherapy with autologous bone marrow transplantation produces durable remissions in acute myelogenous leukemia. Bone Marrow Transplantation 1990; 5: 111-118. TABLE 1 CR DURATION RELAPSE FREE PATIENTS NUMBER: 10/18 (56%) MEDIAN DURATION: 64+ MONTHS 76+, 67+, 56+, 68+, 68+, 68+, 62+, 59+, 58+, 55+ TABLE 2 CR DURATION RELAPSED PATIENTS NUMBER: 8/18 (44%) MEDIAN DURATION: 19 MONTHS 24, 22, 29, 29 18, 13, 9, 7
17 Double Intensification and ABMT TABLE 3 PROGNOSTIC FACTORS AND OUTCOME ATTER CBV Median No. of CR Prognosis Pts £££ Duration Cnos\ Good 12 8 (67%) 64+ 0.069 Bad 6 2 (33%) 19 Prognostic Model: P.CRl, Keating, et al. (Ref .2) TABLE 4 FRONT-LINE THERAPY FOR ADULT AML RISK GROUPS • Good prognosis: Karyotypes: inv 16 diploid + (15;17) 45 X-Y. + (3/21) and Achievement of CR in one cycle • Poor prognosis: CD 34 (+) blasts > 70% Any karyotype other than above Above karyotypes if > 1 cycle to CR
Page 3: UBiv»rstt5ts-Krauk8Biiaas Eppendor
Page 6 and 7: Publication of these proceedings is
Page 8 and 9: B. Relapse JE Sanders, RHill, F App
Page 10 and 11: SESSION 3: CHRONIC MYELOGENOUS LEUK
Page 12 and 13: JP Eder and BA Teicher New Agents i
Page 14 and 15: AMCarella, P Codier, A Congiu, E Ga
Page 16 and 17: G Rosti, M Leoni, L Atbertazd, R Sa
Page 18 and 19: B Bostrom Can Maximal Dose Chemothe
Page 21: ACKNOWLEDGEMENTS The organizers tha
Page 24 and 25: 4 Session 1: Acute Myelogenous Leuk
Page 26 and 27: 6 Session 1: Acute Myelogenous Leuk
Page 29 and 30: 9 ABMT vs. Chemotherapy in Adults:
Page 31: 11 ABMT vs. Chemotherapy in Adults:
Page 34 and 35: 14 Session 1: Acute Myelogenous Leu
Page 43 and 44: 23 Role of Marrow Purging AUTOLOGOU
Page 45 and 46: Role of Marrow Purging 25 the leuke
Page 47 and 48: 27 Role of Marrow Purging The distr
Page 49 and 50: Role of Marrow Purging 29 REFERENCE
Page 51 and 52: 31 Role of Marrow Purging TABLE 2 A
Page 53 and 54: 33 Role of Marrow Purging FIGURE 3
Page 55 and 56: 35 Role of Marrow Purging FIGURE 7
Page 57 and 58: 37 ABMT: An Eastern Cooperative Onc
Page 59 and 60: 39 ABMT: An Eastern Cooperative Onc
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66 Session 1: Acute Myelogenous Leu
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77 BAVC Followed by Unpurged Marrow
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79 BAVCFollowedby Unpurged Marrow I
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81 ABMT with Unpurged Marrow AUTOLO
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ABMT with Unpurged Marrow 83 Kaplan
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85 ABMT with Unpurged Marrow 4. Gol
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87 ABMT with Unpurged Marrow TABLE
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89 ABMT with Unpurged Marrow FIGURE
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100 Session 1: Acute Myelogenous Le
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102 Session 1: Acute Myelogenous Le
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105 ABMT with 4-HC Purged Marrow AU
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107 ABMT with 4-HC Purged Marrow RE
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109 ABMT with 4-HC Purged Marrow de
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ABMT wüh 4-HC Purged Marrow TABLE
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113 MonoclonalAntibody-PurgedABMT N
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115 Monoclonal Antibody-PurgedABMT
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117 MonoclonalAntibody-PurgedABMT (
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119 MonoclonalAntibody-PurgedABMT R
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121 MonoclonalAntïbody-PurgedABMT
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123 Prognostic Factors for Hematolo
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135 Cell Proliferation Studies with
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Cell Proliferation Studies with AST
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145 Detection of Minimal Residual D
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152 Session 2: Acute Lymphocytic Le
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167 ABMT: Report from Dana Farber C
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177 Bone Marrow Purging BONE MARROW
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179 Bone Marrow Purging intermediat
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181 Bone Marrow Purging Clinical Ou
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183 Bone Marrow Purging 12. Ramsay
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185 Bone Marrow Purging TABLE 4 Sum
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187 Bone Marrow Purging FIGURE 3 Di
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202 Session 2: Acute Lymphocytic le
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205 Chemotherapy Regimens and BMT I
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207 Chemotherapy Regimens and BMT F
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209 Chemotherapy Regimens and BMT F
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211 Detection of Minimal Residual L
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220 Session 3: Chronic Myelogenous
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255 Approaches to Prevent Relapse A
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257 Approaches to Prevent Relapse F
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260 Session 4: Supportive Care in g
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262 Session 4: Supportive Care REFE
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264 Session 4: Supportive Care TABL
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267 Gram-Positive Septicemia CHARAC
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269 Cram-Positive Septicemia treatm
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271 Gram-Positive Septicemia Guiot
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273 Ann' Fungal Therapy FLUCONAZOLE
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275 Anti Fungal Therapy > different
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277 Ana Fungal Therapy 19. Kroger H
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279 Ana Fungal Therapy TABLE 2 INTE
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282 Session 4: Supportive Care port
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284 Session 4: Supportive Care infe
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286 Session 4: Supportive Care REFE
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289 COBE Spectra BONE MARROW CONCEN
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291 COBE Spectra precursor assay (C
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293 COBE Spectra TABLE 2 DEPLETION
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295 COBE Spectra FIGURE 2 PROCEDURE
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298 Session 4: Supportive Care The
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300 Session 4: Supportive Care DISC
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302 Session 4: Supportive Care 14.
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304 Session 4: Supportive Care FIGU
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306 Session 5: Breast Cancer - Meta
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308 Session S: Breast Cancer - Meta
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313 High Dose Therapy wäh ABMT HIG
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315 High Dose Therapy with ABMT Thi
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317 High Dose Therapy with ABMT for
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319 High Dose Therapy with ABMT aut
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321 High Dose Therapy with ABMT TAB
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338 Session S: Breast Cancer - Meta
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343 High Dose Therapy and ASC Rescu
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353 High Dose Chemotherapy andBM HI
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355 High Dose Chemotherapy and BMT
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357 High Dose Chemotherapy and BMT
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359 High Dose Cliemotherapy and BMT
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361 High Dose Qiemotherapy and BM T
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364 Session 5: Breast Cancer - Pre-
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368 Session S: Breast Cancer - Pre-
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373 New Agents in Chemotherap NEW A
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375 New Agents in Chemotherapy of a
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377 New Agents in Chemotherap 17. M
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380 Session 6: Breast Cancer- Pre-M
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393 ABMT: Cooperative Pilot Study R
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397 ABMT: Cooperative PUot Study Re
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401 ÄBMT' Cooperative Pilot Study
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405 Factors Affecting ABMT Results
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411 Parma Pilot Study RELAPSE OF MA
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413 Parma Pilot Study ABMT in the p
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415 Parma Pilot Study Netherlands;
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417 Parma Pilot Study FIGURE 1 PARM
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420 Session 6: Lymphoma - Non-Hodgk
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427 High Dose Etoposide and Melphal
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436 Session 6: Lymphoma • Non-Hod
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444 Session 6: Lymphoma • Non-Hod
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454 Session 6: Lymphoma - Low Grade
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465 Ablative Therapy with ABMT ABLA
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467 Ablative Therapy with ABMT RESU
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469 Ablative Therapy with ABMT REFE
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471 Ablative Therapy with ABMT TABL
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474 Session 6: Non-Hodgkin's Lympho
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487 Studies with Sequential Transpl
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502 Session 6: Lymphoma - Hodgkin's
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518 Session 6: Lymphoma - Hodgkin*s
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520 Session 6: Lymphoma - Hodgldn's
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529 ABMT and Cooperative Group Tria
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531 ABMT and Cooperative Group Tria
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533 ABUT and Cooperative Group Tria
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535 ABMTand Cooperative Group Trial
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537 ABMTandCooperative Group Trials
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540 Session 6: Lymphoma PATIENTS AN
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542 Session 6: Lymphoma RESULTS Lym
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544 Session 6: Lymphoma with TBI; t
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546 Session 6: Lymphoma TABLE 1 CON
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548 Session 6: Lymphoma TABLE 5 PAT
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551 Prospects for the Future AUTOGR
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553 Prospects for the Future relaps
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555 Prospects for the Future amelio
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557 Prospects for the Future which
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559 Prospects for the Future OVERVI
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561 Prospects for the Future FIGURE
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564 Session 6: Lymphoma - Myeloma M
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566 Session 6: Lymphoma - Myeloma R
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568 Session 6: Lymphoma - Myeloma 9
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570 Session 6: Lymphoma - Myeloma F
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572 Session 6: Lymphoma - Myeloma I
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574 Session 6: Lymphoma - Myeloma w
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576 Session 6: Lymphoma - Myeloma T
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578 Session 6: Lymphoma - Myeloma T
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580 Session 6: Lymphoma - Myeloma F
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582 Session 6: Lymphoma - Myeloma A
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584 Session 6: Lymphoma - Myeloma R
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587 Neuroblastoma in Children OUTCO
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589 Neuroblastoma in Children the 3
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591 Neuroblastoma in Children Remis
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593 Neuroblastoma in Children TABLE
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595 Neuroblastoma in Children FIGUR
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597 Neuroblastoma in Children FIGUR
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600 Session 7: Solid Tumors and Eto
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602 Session 7: Solid Tumors patient
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604 Session 7: Solid Tumors state a
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606 Session 7: Solid Tumors TABLE l
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608 Session 7: Solid Tumors TABLE 2
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612 Session 7: Solid Tumors was ass
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614 Session 7: Solid Tumors microme
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616 Session 7: Solid Tumors 13. Dim
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620 Session 7: Solid Tumors Protoco
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622 Session 7: Solid Tumors at diag
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624 Session 7: Solid Tumors immunol
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626 Session 7: Solid Tumors 3. Favr
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628 Session 7: Solid Tumors TABLE I
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630 Session 7: Solid Tumors TABLE m
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632 Session 7: Solid Tumors childre
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634 Session 7: Solid Tumors 6. Doug
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636 Session 7: Solid Tumors FIGURE
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638 Session 7: Solid Tumors BCNU wa
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640 Session 7: Solid Tumors enhance
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642 Session 7: Solid Tumors constan
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647 Germ Cell Neoplasms DOSE INTENS
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649 Germ &tt Neoplasms Indiana Univ
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651 Germ CeUNeophsms Non-hematologi
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653 Germ Cell Neoplasms Cancer. A S
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656 Session 7: Solid Tumors Twelve
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658 Session 7: Solid Tumors 5. Rich
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661 Dose Intensive Therapy DOSE INT
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663 Dose Intensive Therapy compared
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665 Dose Intensive Therapy of thera
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6 6 7 Dose Intensive Therapy TABLE
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670 Session 7: Solid Tumors drugs c
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672 Session 7: Solid Tumors cisplat
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677 Conditioning Regimen for BMT BU
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679 Conditioning Regimen for BMT To
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681 Conditioning Regimen for BMT TA
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683 Conditioning Regimen for BMT TA
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685 Conditioning Regimen for BMT FI
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688 Session 7: Solid Tumors consist
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693 ABMT for Arthritis in Rats REMI
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695 ABMT for Arthritis in Rats It i
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697 ABMT for Arthritis in Rats FIGU
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700 Session 8: New Avenues MATERIAL
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702 Session 8: New Avenues positive
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704 Session 8: New Avenues Previous
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706 Session 8: New Avenues FIGURE 1
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712 Session 8: New Avenues to thiou
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714 Session 8: New Avenues analysis
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716 Session 8: New Avenues Liver vo
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718 Session 8: New Avenues TABLE 1
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724 Session 8: New Avenues 1, dose-
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726 Session 8: New Avenues Bone mar
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728 Session 8: New Avenues ACKNOWLE
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730 Session 8: New Avenues TABLE 1
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734 Session 8: New Avenues transfer
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736 Session 8: New Avenues a concen
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738 Session 8: New Avenues Beta 5'U
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740 Session 8: New Avenues 5. Stoec
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751 Immunocytochemical Detection of
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763 Immunotherapy: Post-ABMT Implic
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771 Immunostimulation Post-ABMT IMM
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773 Immunostimulation Post-ABMT are
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775 Immunostimulation Post-ABMT cul
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Ill Immunostimulation Post-ABMT 4.
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779 Immunostimulation Post-ABMT FIG
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781 ImmuMstimuIation Post-ABMT FIGU
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783 Myelosuppressive Chemotherapy P
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785 Myelosuppressive Chemotherapy P
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787 Myelosuppressive Chemotherapy m
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789 Myelosuppressive Chemotherapy T
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791 Mobilization Techniques THE ROL
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793 Mobilization Techniques Cell an
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795 Mobilization Techniques 8. Bran
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797 Mobilization Techniques FIGURE
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799 Mobilization Techniques FIGURE
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802 Session 9: Peripheral Stem Ceil
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804 Session 9: Peripheral Stem Cell
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806 Session 9: Peripheral Stern Cel
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823 Acute Myeloid Leukemia PERIPHER
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825 Acute Myeloid Leukemia leukemic
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827 Acute Myeloid Leukemia after hi
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837 Relapsed Lymphomas and Marrow M
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839 Relapsed Lymphomas and Marrow M
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841 High Risk Myeloma AUTOLOGOUS BL
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843 High Risk Myeloma analysis for
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845 High Risk Myeloma encountered,
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847 High Risk Myeloma 10. Debecker
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849 High Risk Myeloma TABLE 2 ABSCT
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852 Session 10: Hematopoietic Growt
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881 Role of Monocytes THE ROLE OF M
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883 Role of Monocytes cells, always
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885 Role of Monocytes CONCLUSION Th
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887 Role of Monocytes TABLE 2 Proge
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889 Role of Monocytes FIGURE 1 cont
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891 Role of Monocytes FIGURE 3 Kine
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893 InterleuIdn-2 Post-ABMT USE OF
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895 Iníerkukin-2 Posí-ABMT Specif
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897 Interleukin-2 Post-ABMT years;
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899 Interieukin-2 Post-ABMT 19. Lau
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901 Interleukin-2 Post-ABMT TABLE 2
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903 Interleuldn-2 Post-ABMT FIGURE
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905 Autotransplants: Present and Fu
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912 Session 11: Concluding Remarks
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CONTRIBUTORS Tauseef Ahmed, M.D., N
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Anthony Elias, M.D., Dana Färber C
Page 939 and 940:
Per Ljungman, M.D., Ph.D., Departme
Page 941:
Yoichi Takaue, M.D., Department of
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