Modern Trends in Human Leukemia VI - Blog Science Connections

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,. I .) . r Participants of the Meeting I . I ' , C I '\ I ! --;. . '- . ..:: '- (' i I \ VI \ ........ -' : '.- Anders, Fritz, Genetisches Institut, Heinrich-Buff-Ring 58-62, 6300 Giessen, FRG Aoki, Tadao, Shinrakuen Hospital, Nishiariakecho 1-27, Niigatashi, Japan Bauer, Heinz, Institut flir Virologie, Frankfurter Strasse 107,6300 Giessen, FRG Beato, Miguel, Institut flir Physiologische Chemie I, Emil-Mannkopff-Strasse 1-2, D-3550 Marburg, FRG Bertino, Joseph R., Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA Beug, Hartmut, European Molecular Biology Laboratory, Meyerhofstrasse 1, 6900 Heidelberg, FRG Bloomfield, Clara Derber, Coleman Leukemia Research and Treatment Center, Sect. Medical Oncology, 420 Delaware Street S.E., Minneapolis, Minnesota 55455, USA x: Blume, Karl G., Dept. Hematology and Bone Marrow Transplantation, City of Hope National Med. Center, 1500 East Duarte Road, Duarte, California 91010, USA Boguslawska-Jaworska, Janina, Institute of Pediatrics, Dept. Hematology, ul. Smoluchowskiego 32/4, 50-373 Wroc1aw, Poland Bosco, John, Dept. Medicine, University of Malaya, Kuala Lumpur, Malaysia ABrandeis, Werner, Kinderklinik, Sektion Onkologiellmmunologie, 1m Neuenheimer Feld 150,6900 Heidelberg, FRG Browne, Marcia T. *, Pediatric Branch, Clinical Oncology Program, Div. of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Burny, Arsene, Laboratoire de Chimie Biologique, 67 Rue des Chevaux, 1640 Rhode-St.-Genese, Belgium Castaigne, S., Service d'Hematologie du Pr Boiron, Hopital St. Louis, Paris, France Chieco-Bianchi, Luigi, Instituto di Anatomia Patologica, Cattedra di Oncologia, Via Gattamelata 64, 35128 Padova, Italy Clark, Edward A., Genetic Systems Corporation, 3005 First Avenue, Seattle, Washington 98121, USA Clarkson, Bayard, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, N.Y. 10021, USA Conez, Dominique, Departement de Biologie Moleculaire, Laboratoire de Chimie Biologique, 67 Rue des Chevaux, 1640 Rhode-St.-Genese, Belgium Cooper, Geoffrey M., Sidney Farber Cancer Institute, Lab. Molecular Carcinogenesis, 44 Binney Street, Boston, Massachusetts 02115, USA Coutinho, Antonio, Institut Pasteur, 28, Rue du Dr. Roux, 75724 Paris Cedex 15, France Cowling, Graham J., Searle Research & Development, Lane End Road, High Wycombe, Bucks HPl2 4HL, England Croce, Carlo M., The Wistar Institute, 36th Street at Spruce, Philadelphia, Pennsylvania, USA XVII
Dalgleish, Angus, Institute of Cancer Research, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, England Deinhard, Friedrich, Max v. Pettenkofer-Institut fUr Hygiene und Mikrobiologie, Pettenkoferstrasse 9 a, 8000 MUnchen 2, FRG Dexter, T. Michael, Christie Hospital & Holt Radium Institute, Dept. Experimental Haematology, Wilmslow Road, Manchester M20 9BX, England Dube, Shyam, Dept. Pharmacology, Sterling Hall of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA ,.xDuesberg, Peter H., Dept. Molecular Biology, Wendell M. Stanley Hall, Bergeley, California 94720, USA Eaves, Connie, Terry Fox Laboratories, B.C. Cancer Research Center, 601 West 10th Avenue, Vancouver, B.c. V52 IL3, Canada Elstner, Elena, Universitatsklinik f. Innere Med., Schumannstrasse 20122, 1040 Berlin, GDR Feldman, Michael, The Weizman Institute of Science, Dept. Cell Biology, 76100 Rehovot, Israel Francis, Gillian E., The Royal Free Hospital, Pond Street, Hamstead, London NW3 2QG, England Gaedicke, Gerhard, Universitatskinderklinik, Prittwitzstrasse 43, 7900 VIm, FRG Gaffin, Stephen L.*, Dept. of Physiology, University of Natal Med. School, P.O. Box 17039,4013 Congella, South Africa , Gallo, Robert c., National Cancer Institute, Bethesda, Maryland 20205, USA .:./ Ganser, Arnold, Zentrum flir Innere Medizin, Abteilung fUr Innere Medizin III, Hamatologie und Onkologie, Steinhovelstr. 9, 7900 Ulm, FRG Gissmann, Lutz, Deutsches Krebsforschungszentrum, 1m Neuenheimer Feld 280, 6900 Heidelberg, FRG Goldmann, Shraga Felix*, Abt. Transplantationsimmunologie der DRK-Blutspendezentrale, Oberer Eselsberg 10, 7900 Ulm, FRG Gough, Nicholas M., Ludwig Institute for Cancer Research, Melbourne, Victoria 3050, Australia Gramatzki, Martin, Institut und Poliklinik fUr Klinische Immunologie und Rheumatologie, Krankenhausstrasse 12, 8520 Erlangen, FRG Greaves, Melvyn F., Imperial Cancer Research Fund Laboratories, Membrane Immunology Laboratory, London WC2A 3PX, England Greene, Warner c., National Institutes of Health, Building 10, Room 4N117, Bethesda, Maryland 20205, USA Haas, R J., Dr. v. Haunersches Kinderspital, Abt. Hamatologie & Onkologie, Lindwurmstrasse 4, 8000 MUnchen 2, FRG Hahn, Beatrice, National Cancer Institute, Bethesda, Maryland 20205, USA Harel, Jacques, Institut Gustave-Roussy, 39-53, Rue Camille Desmoulins, 94805 Villejuif, France Hadozinska-Smyrka, Antonia, Akademia Medyczna, Katedra I Zaklad Anatomii Pathologicznej, 50-368 Wroclaw, Poland zur Hausen, Harald, Deutsches Krebsforschungszentrum, 1m Neuenheimer Feld 280, 6900 Heidelberg, FRG Hayman, Michael, Imperial Cancer Research Fund Laboratories, Dominion House, London ECIA 7BE, England )c Hehlmann, RUdiger, Medizinische Klinik, Pettenkoferstrasse 8 a, 8000 MUnchen 2, FRG von der Helm, Klaus, Max v. Pettenkofer-Institut fUr Hygiene und Mikrobiologie, Pettenkoferstrasse 9 a, 8000 MUnchen 2, FRG Henderson, Edward S., Roswell Park Memorial Institute, Medicine A, 666 Elm Street, Buffalo, N.Y. 14263, USA Higi, M.*, Klinik Dr. Schedel, 8391 Kellberg-Passau, FRG Hoelzer, Dieter, Zentrum der Inneren Medizin, Abteilung flir Hamatologie, Universitlit Frankfurt, Theodor-Stern-Kai 7, 6000 Frankfurt/Main 70, FRG Hofschneider, Peter-Hans, Max-Planck-Institut fUr Biochemie, 8033 Martinsried, FRG Hossfeld, Dieter, II. Medizinische Univ. Klinik, Abt. Onkologie und Hamatologie, Martinistrasse 52, 2000 Hamburg 20, FRG XVIII
Page 1 and 2: Modern Trends in Human Leukemia VI
Page 3 and 4: Contents Participants of the Meetin
Page 5 and 6: "J. R. Bertino, S. Srimatkandada, M
Page 7 and 8: I F. Anders, M. Schartl, A. Barneko
Page 9 and 10: G. R. Johnson, W. Ostertag, and N.
Page 11: L P. Witz, M. Efrati, R. Ehrlich, B
Page 15 and 16: Micheel, Burkhard, Forschungszentru
Page 17 and 18: Wilsede Scholarship Holders Bartram
Page 19 and 20: Nicht mude werden sondern dem Wunde
Page 21 and 22: to be underestimated; in an increas
Page 23 and 24: Personal and scientific discussion
Page 25 and 26: Haematology and Blood Transfusion V
Page 29 and 30: Table 1. Documentation of reactivit
Page 35 and 36: MC 29 proto-myc Genetic Structure X
Page 37 and 38: plasmid vectors do not transform no
Page 39 and 40: MH2 virus * OKlO virus normal chick
Page 41 and 42: proliferation of certain stem cells
Page 43 and 44: tumors survive, also suggests that
Page 45 and 46: ole in a multi gene carcinogenesis
Page 47 and 48: 26. Watson DK, Reddy EP, Duesberg P
Page 49 and 50: tion in MoMuLV-induced rat thymic l
Page 51 and 52: carcinomas in rats by nitroso-methy
Page 55 and 56: approaches to the prevention and tr
Page 57 and 58: Table 1. Monoclonal antibodies and
Page 59 and 60: marrow purging for removal of GVHDp
Page 63 and 64:
References 1. Blume KG, Beutler E,
Page 65 and 66:
adiation administered to these pati
Page 67 and 68:
order or who had previous chemother
Page 69 and 70:
[5-7). Our current results, coverin
Page 71 and 72:
Table 1. Prognostic factors for rem
Page 73 and 74:
Haematology and Blood Transfusion V
Page 75 and 76:
Page 77 and 78:
penia, and recovery of the peripher
Page 79 and 80:
Table 1. Results of therapy with lo
Page 81 and 82:
40% of the cases, CR was obtained w
Page 83 and 84:
Table 1. Clinical data of the nine
Page 85 and 86:
Page 87 and 88:
Total Fail 0,2] relapse - free surv
Page 89 and 90:
Page 91 and 92:
Table 4. Clinical features of adult
Page 93 and 94:
Table 1. Summary of 232 patients in
Page 95 and 96:
pared with an extended period, but
Page 97 and 98:
Page 99 and 100:
ciT -ALL n· 5 1UU-r""""t:::::==:::
Page 101 and 102:
Study X-H examines the efficacy of
Page 103 and 104:
clearance influences the probabilit
Page 105 and 106:
Table 1. AML-BFM-78 results by morp
Page 107 and 108:
SR r---ll.--' ma Standard risk pati
Page 109 and 110:
sisting of two phases, was identica
Page 111 and 112:
.. .•.................•.. t~._.
Page 113 and 114:
Table 1. Dihydrofolate reductase ac
Page 115 and 116:
sistance to this antifolate. In one
Page 117 and 118:
genes in cultured mouse fibroblasts
Page 119 and 120:
ferentiation, and fresh pro myelocy
Page 121 and 122:
ful in advising patients who have s
Page 123 and 124:
28. Dicke KA (1983) Purging of marr
Page 125 and 126:
Table 1. RBC-enriched blood units R
Page 127 and 128:
fusion reaction (2.5 X lOB leukocyt
Page 129 and 130:
Page 131 and 132:
c. Summary of Animal Studies Using
Page 133 and 134:
5. Davis D, Brown K, Douglas H, Tak
Page 135 and 136:
apy varies in different studies, wi
Page 137 and 138:
iotics and reevaluate the patient o
Page 139 and 140:
iopsy, of whom 8 improved and 4 (33
Page 141 and 142:
Page 143 and 144:
agents. Several agents of this clas
Page 145 and 146:
Page 147 and 148:
Table 2. Seven controlled therapeut
Page 149 and 150:
Table 5. Incidence ofimmediate, non
Page 151 and 152:
transfusion. Finally, transfusion-a
Page 153 and 154:
fects on donors of intermittent-flo
Page 155 and 156:
ceived leukocyte-poor red blood cel
Page 157 and 158:
until 3-5 weeks after initial antig
Page 159 and 160:
Page 161 and 162:
ecause of the almost immediate adve
Page 163 and 164:
2. Treatment Tolerance Benefits Tre
Page 165 and 166:
Page 167 and 168:
Page 169 and 170:
Table 1. Karyotype findings which d
Page 171 and 172:
Cl 1.0 c .9 I .s: .s: ... . 8 = en
Page 173 and 174:
ABC o E f G H J J" 'K kb .. 4 .8 Ii
Page 175 and 176:
p q 3 22 - bcr - c- sis c-obl Fig.
Page 177 and 178:
-285 Fig. 1. Absence of sis RNA in
Page 179 and 180:
also had this transcript, but it is
Page 181 and 182:
Page 183 and 184:
Table 2. Mutations affecting amino
Page 185 and 186:
Page 187 and 188:
C. Long-Term CML Marrow Cultures Fo
Page 189 and 190:
References 1. Fauser AA, Messner HA
Page 191 and 192:
:::: 2h sedimel rtation ':: leucocy
Page 193 and 194:
Senba M, Hamane M, Kanamaru A, Naga
Page 195 and 196:
60 ERYTHROILASTS IN lONE MAllOW % 1
Page 197 and 198:
Fig. 1. Normal bone marrow erythrob
Page 199 and 200:
Fig.4. 3C5-positive (gold labelled)
Page 201 and 202:
G, Caen J (1981) Monoclonal antibod
Page 203 and 204:
J ~ Calf intestinal & - alkali ne p
Page 205 and 206:
Page 207 and 208:
30 Fig. 3. Follow-up study of a pat
Page 209 and 210:
Page 211 and 212:
Fig. 1 a-c. Ion exchange chromatogr
Page 213 and 214:
Table 1. Reactivity of the patient'
Page 215 and 216:
11. Stashenko P, Nadler LM, Hardy R
Page 217 and 218:
Table 1. NCA content in peripheral
Page 219 and 220:
Page 221 and 222:
ogen activators secreted by human c
Page 223 and 224:
AML ALL NK cell activity (% cytolys
Page 225 and 226:
Table 2. Killer activity of periphe
Page 227 and 228:
Table 1. Summary of the antibody re
Page 229 and 230:
Page 231 and 232:
Table 1. Parameters for the discrim
Page 233 and 234:
Table 2. Parameters for the discrim
Page 235 and 236:
Fig. 3 A-C. Stepwise discriminant a
Page 237 and 238:
Mechanism of Malignant Transformati
Page 239 and 240:
1.Region: Va.£ t t~ t t Vo..e Su t
Page 241 and 242:
GENES -600 -500 -400 -300 -200 -100
Page 243 and 244:
oid hormones share some of the prop
Page 245 and 246:
Page 247 and 248:
most often result in premature chai
Page 249 and 250:
Page 251 and 252:
a) X ~// __ p_t~er ____ R_c~O ____
Page 253 and 254:
2 1 PP60 C - SRC KINASE ACTIVITY PR
Page 255 and 256:
platyfish-derived melanoma-mediatin
Page 257 and 258:
Table 1. SCE frequency in intestina
Page 259 and 260:
A B Fig. 11 A, B. Backcross hybrids
Page 261 and 262:
Table 3. Elevated pp60 c - src kina
Page 263 and 264:
expression, the transformed cells o
Page 265 and 266:
NORMAL MELANOPHORE PATTERN Homeosta
Page 267 and 268:
"0 IV III d IV :::J ~ "0 8.0 C iii
Page 269 and 270:
pmol Gua incorporated lA 260tRNA Sk
Page 271 and 272:
:!;!!j!~.!!~!~!!!!!Il:iiiiiiii!!!!!
Page 273 and 274:
Biochemical and clinical aspects of
Page 275 and 276:
the cells in the early indolent sta
Page 277 and 278:
II. Other Human Leukemias and Lymph
Page 279 and 280:
8 1 2 3, Ii 1 , 8 9 10 '13 1.4 15 1
Page 281 and 282:
38. Spurr NK, Solomon E, Jannson M,
Page 283 and 284:
6392 L '31 2 3 2 3 4 5 I 2 :; 4 5 .
Page 285 and 286:
PF BL 3 1 2- 3 4· 5 2 3 4 Fig. 3.
Page 287 and 288:
Page 289 and 290:
Fig.3. Indirect immunofluorescence
Page 291 and 292:
Table 1. Oncogenic properties of ac
Page 293 and 294:
transouceo by aVIan acute leukemia
Page 295 and 296:
ing mutations appear to induce conf
Page 297 and 298:
II. Finkel T, Der CJ, Cooper GM (19
Page 299 and 300:
quence; and pMHCI, and MHCI cross-r
Page 301 and 302:
Page 303 and 304:
fcoRl Sphl pMH2-E p3611 MSV-E [/01
Page 305 and 306:
Page 307 and 308:
Asn Fig. 2. Structures and the site
Page 309 and 310:
not surprising since the plasma mem
Page 311 and 312:
Page 313 and 314:
Table 1. Characterization of erythr
Page 315 and 316:
Immature cells ~$6cu l 01 euk:$mic
Page 317 and 318:
erbB + erbA erbB src fps ets S13 no
Page 319 and 320:
Page 321 and 322:
200 -- 92 1 .... 16 '9 ~ 46 .... 30
Page 323 and 324:
Page 325 and 326:
OUTSIDE INSIDE PROTEIN :3 PROTEIN~
Page 327 and 328:
Page 329 and 330:
Page 331 and 332:
Table 2. Endemic and sporadic BL ce
Page 333 and 334:
Page 335 and 336:
Page 337 and 338:
I fO--; ,. t ll6-' I Fig. 18, b. Co
Page 339 and 340:
HTLV-I Fig. 1. Electron microscopy
Page 341 and 342:
3: a: -_ -o_a: -I E-: CO ... co .c
Page 343 and 344:
66 51- 41- 31- 2,4- 1, A 2' :3 4, ,
Page 345 and 346:
32. Popovic M, Sarin PS, Robert-Gur
Page 347 and 348:
Page 349 and 350:
HTLV Fig. 1. Transcriptional activa
Page 351 and 352:
divergence in their envelope genes.
Page 353 and 354:
z I~ ~ ~ : -< 'Ie ~ r... z ~ 0 4III
Page 355 and 356:
served antigenic sites in the nativ
Page 357 and 358:
Table 1. Number of HTL V antibody-p
Page 359 and 360:
Page 361 and 362:
1 .2 3 4 5 6 Fig. 1. Immunoprecipit
Page 363 and 364:
Page 365 and 366:
Table 3. Complement-dependent cytot
Page 367 and 368:
Table 1. Serum samples from three s
Page 369 and 370:
products show conservation in their
Page 371 and 372:
Page 373 and 374:
Type .of myeloid cells Requirement
Page 375 and 376:
and differentiation in normal myelo
Page 377 and 378:
constitutive to the nonconstitutive
Page 379 and 380:
lasts: separately programmed pathwa
Page 381 and 382:
Page 383 and 384:
term haemopoietic cell growth facto
Page 385 and 386:
Serial Recloning of Cells from SRC
Page 387 and 388:
such cells clearly have an extended
Page 389 and 390:
48. Waterfield MD, Scrace OT, Whitt
Page 391 and 392:
oth cells proliferating with simila
Page 393 and 394:
oth growing exponentially, became t
Page 395 and 396:
Table 1. Colony types producing cel
Page 397 and 398:
4. Hankins WD, Kost TA, Koury MJ, K
Page 399 and 400:
S'UT 100bp L-..J Mature p protein 3
Page 401 and 402:
200 180 160 1140 ~ ~ 120 '5 Ii; 100
Page 403 and 404:
Page 405 and 406:
...J m CL ,..;0 ,(t) - I J: W ~ ' 5
Page 407 and 408:
with oligo( d1)-cellulose. Using ap
Page 409 and 410:
11 2 3 4 13 14 20 21 N N 23 28; 30
Page 411 and 412:
28s~ 7.5Kb- 5"BKb !5.6Kb - 18s- 4
Page 413 and 414:
IS. Maniatis T, Fritsch EF, Sam bro
Page 415 and 416:
ammonium chloride. After extensive
Page 417 and 418:
Table 1. Purification of human plur
Page 419 and 420:
The availability of purified human
Page 421 and 422:
therapy with varied results, in som
Page 423 and 424:
~ 3 • ..:a ~ 25 CI ~2I g a 15 a:
Page 425 and 426:
+:>. o -.l ~ 71 ...1 ~ al ~ 51 ~ ..
Page 427 and 428:
Page 429 and 430:
We measured the specific uptake of
Page 431 and 432:
Table 2. Effects of 1,25(OH)2D3 and
Page 433 and 434:
Table 3. Preleukemic patients: clin
Page 435 and 436:
We attempted to improve the periphe
Page 437 and 438:
and macrophages [II]. This was stud
Page 439 and 440:
The murine Interleukin-3-dependent
Page 441 and 442:
Page 443 and 444:
References 1. Burgess AW, Metcalf D
Page 445 and 446:
''B cell$ I I I' THYMU8 ( I I I I I
Page 447 and 448:
Because of the tissue culture envir
Page 449 and 450:
Fig. 1. Induction of differentiatio
Page 451 and 452:
Page 453 and 454:
(FRO), and Research Institute, Roya
Page 455 and 456:
Table 1. Monoclonal antibodies used
Page 457 and 458:
PDGF, X308-CM, and RA did not signi
Page 459 and 460:
Page 461 and 462:
Table 2. Antibody Ki-I reactivity i
Page 463 and 464:
Page 465 and 466:
Immunological Aspects in Malignancy
Page 467 and 468:
Immunohistochemical analysis of thy
Page 469 and 470:
vivo. To study this, we assayed the
Page 471 and 472:
on T lymphoma cells in lymphoma cel
Page 473 and 474:
II. Cell, Preparation, Staining, an
Page 475 and 476:
Table 1. Relative antigen expressio
Page 477 and 478:
12. Janeway CA Jr, Bottomly K, Babi
Page 479 and 480:
further markers, cannot be affiliat
Page 481 and 482:
Table 3. B cell subpopulations in t
Page 483 and 484:
I .. Fig.2a-c. B-CLL cells after 72
Page 485 and 486:
circul. + SPleeyn 9M + (\190+ ~ n
Page 487 and 488:
21. Ly CY, Yam LT, Lam KW (1970) Ac
Page 489 and 490:
Table 1. The BW.BR anti-K b C1L rep
Page 491 and 492:
10 Bl0.BR Fig.3. Comparison of recu
Page 493 and 494:
Fig. 5. The effect of recombination
Page 495 and 496:
Thus, germ-free mice maintained on
Page 497 and 498:
physiology from the pathology of au
Page 499 and 500:
SPLEEN CELLS OR LPS BLASTS lysing w
Page 501 and 502:
Table 1. Proliferative response of
Page 503 and 504:
Page 505 and 506:
Fig. 1A-C. A Kinetics of antigen pe
Page 507 and 508:
------~-/------.-CAPSULE II. I. / ~
Page 509 and 510:
Page 511 and 512:
Table 2. The NK activity of splenoc
Page 513 and 514:
Table 5. The binding pattern of nat
Page 515 and 516:
16. Snyder HW Jr, Fleissner E (1980
Page 517 and 518:
Table 1. Metastases and H-2 express
Page 519 and 520:
Cf) ...I ...I W U I.L.. 0 0: W CD :
Page 521 and 522:
100 80 60 40 Q) II> 20 0 .!!! e .5
Page 523 and 524:
2.85 - fo's _ 18S - A 2 3 B C 2 3 2
Page 525 and 526:
Page 527 and 528:
References 1. Ziegler HWL, Kay NE,
Page 529 and 530:
adioactivity of the SlCr released w
Page 531 and 532:
Page 533 and 534:
E ;:, ... Q) I/) -0 ~ ... Q) c. -'"
Page 535 and 536:
Subject Index Abl 155 Acute leukemi
Page 537:
PhI-chromosome 151, 154,257 Phorbol
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