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<strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong><br />

The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

‘Building futures,<br />

transforming lives’


2007<br />

2007<br />

2000<br />

2002<br />

1992<br />

1988<br />

2008<br />

1993<br />

1991<br />

1996<br />

1998<br />

1995<br />

2001<br />

1994<br />

1999<br />

2003<br />

2003<br />

1994<br />

2005<br />

2004<br />

1997<br />

2006<br />

As part of the 21st birthday celebrations, MFS commissioned a photograph which included<br />

at least one child from 19 of the 21 years since 1988, when Brett Rigby, the unit's first baby<br />

was born; a total of 26 children aged 10 weeks to 19 1 / 2 years old. The final image is 'comp'd'<br />

together from 12 individual images - even the shadows were added electronically afterwards!<br />

Some of the children met on the day, some met each other at the party, but some still haven't<br />

seen each other even though they're part of the final historic image.


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

Welcome to the <strong>Patients</strong>' Guide<br />

to <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong><br />

Dr Lockwood celebrates ‘21 Magical Years for MFS’<br />

Selecting a fertility clinic and starting treatment<br />

can initially appear to be a complicated<br />

process. This <strong>Patients</strong>' Guide to <strong>Services</strong><br />

explains all about how MFS cares for patients,<br />

and its range of investigation, treatment,<br />

preservation and other services. Details of<br />

costs and terms and conditions are in the<br />

separate Patient Finance Information leaflet.<br />

The guide is intended to demystify fertility<br />

treatment and enable new patients to feel<br />

positive about the available choices and<br />

moving ahead. We hope that current and<br />

former patients and health professionals will<br />

enjoy our latest news and reading about our<br />

success rates for 2007 and 2008. For more<br />

detailed information about MFS visit<br />

www.midlandfertility.com.<br />

Contents<br />

About MFS 2<br />

MFS in 2008-2009 5<br />

<strong>Services</strong> at MFS 8<br />

Getting Started 9<br />

Investigations 10<br />

<strong>Fertility</strong> Investigation Package 10<br />

Ovarian Reserve Testing 11<br />

Recurrent Miscarriage Service 12<br />

Sperm Analysis 13<br />

Treatments and Procedures 14<br />

Intrauterine Insemination (IUI) 14<br />

In Vitro Fertilisation (IVF) 16<br />

Intra Cytoplasmic Sperm<br />

Injection (ICSI) 18<br />

Surgical Sperm Retrieval 20<br />

Egg Sharing and Donation 22<br />

Embryo Freezing, Thawing<br />

and Transfer 24<br />

Surrogacy 26<br />

Embryo Transfer Policy 26<br />

Blastocyst Transfer 27<br />

Preservation <strong>Services</strong> 28<br />

Sperm Freezing 28<br />

Vasectomy Reversal Back-Up 29<br />

Egg Freezing 30<br />

Additional <strong>Services</strong> 32<br />

<strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> | 1


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

About MFS<br />

The MFS Board of Directors (l-r): Judith Baron, chair; Anna Kavanagh, quality and business director;<br />

Su Barlow, laboratory director; Heidi Birch director of nursing services; Dr Gillian Lockwood, medical director<br />

The leading provider<br />

MFS has been a leading provider of assisted<br />

conception services to both private and NHSfunded<br />

patients since 1987. The clinic is<br />

committed to providing the highest possible<br />

standard of care, and success rates and longstanding<br />

contracts with many health authorities<br />

demonstrate this commitment to excellence.<br />

The MFS team continually strives for<br />

improvements in fertility treatments. Skills,<br />

experience, innovation and the constant review<br />

of all aspects of treatment and service mean<br />

MFS can offer patients the best possible<br />

chance of both diagnosing the cause of their<br />

infertility and getting pregnant.<br />

MFS is independent of any larger organisation,<br />

allowing for the expansion and introduction of<br />

new treatments and services. MFS has an<br />

open access policy where selection criteria are<br />

not applied unless required by law or medical<br />

advice.<br />

MFS treats both private and NHS-funded<br />

patients. All patients receive the same high<br />

quality care and have access to all members of<br />

the clinical and scientific teams.<br />

2 | <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong>


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

Dedicated to patient care<br />

MFS has a dedicated team of professionals,<br />

including fertility nurse specialists, clinical<br />

midwives, obstetrician / gynaecologists,<br />

embryologists, laboratory technicians,<br />

independent counsellors and administrative,<br />

business support and housekeeping staff.<br />

Doctors, fertility nurse specialists or a clinical<br />

midwife are the main points of contact during<br />

the care of every patient, providing friendly<br />

faces throughout treatment. The clinic also<br />

provides 24 hour emergency cover.<br />

<strong>Fertility</strong> nurse specialist Vicki Robinson and clinical<br />

research fellow Dr Karolina Palinska-Rudzka<br />

Location, privacy and comfort<br />

MFS is located in a discreet modern building<br />

which offers easy access, privacy and comfort.<br />

All the patients at MFS have fertility<br />

investigations or treatment and all the clinic's<br />

services are provided at this site.<br />

Aldridge is a small town north east of<br />

Birmingham, near Sutton Coldfield and<br />

situated on the edge of the Staffordshire<br />

countryside. MFS is easily accessible from<br />

around the UK, close to major road and railway<br />

links and a 45 minute drive from Birmingham<br />

International Airport. Details of<br />

accommodation are available for patients who<br />

would like to stay in the area during key stages<br />

of treatment.<br />

Flexibility<br />

MFS offers a full range of fertility<br />

investigations, preservation services and<br />

treatments, combining excellent clinical care<br />

with clear information, counselling, emotional<br />

support, follow-up care and personal attention<br />

throughout.<br />

Treatment programmes are designed to be as<br />

accessible as possible, keeping the number of<br />

appointments to the minimum required for<br />

quality care. <strong>Patients</strong> are welcome to book<br />

appointments at any available time during the<br />

extended opening hours.<br />

Opening Times<br />

Monday to Friday<br />

Saturday and Sunday<br />

7.30am - 6.30pm<br />

8.00am - 1.00pm<br />

<strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> | 3


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

Making a first appointment<br />

To book a first appointment, please telephone<br />

01922 455911. An initial consultation can<br />

usually be booked within four weeks. New<br />

patients are asked to obtain a referral letter<br />

from their GP or hospital specialist, if possible.<br />

For more information before making a decision<br />

or to look around the clinic, please telephone<br />

MFS and the team will be more than happy to<br />

help. Prospective patients are also welcome to<br />

attend any of MFS's free, no-obligation open<br />

evenings from 6.00-8.00pm on:<br />

Thursday 29 October 2009<br />

Thursday 26 November 2009<br />

Thursday 10 December 2009<br />

Thursday 28 January 2010<br />

Thursday 25 February 2010<br />

Thursday 25 March 2010<br />

Thursday 29 April 2010<br />

Thursday 27 May 2010<br />

Thursday 24 June 2010<br />

Thursday 29 July 2010<br />

Thursday 26 August 2010<br />

Thursday 30 September 2010<br />

Patient Forum<br />

The MFS Patient Forum is an interactive 24/7,<br />

virtual patient support group for past, current<br />

and future MFS patients. Access it free, online<br />

at www.midlandfertility.com.<br />

Keeping patients informed<br />

<strong>Patients</strong> are involved in all decisions about<br />

treatment. MFS's experienced staff guide<br />

them through their fertility investigations or<br />

treatments and provide all the necessary<br />

information and advice to help them make<br />

decisions that optimise their chances of<br />

conceiving.<br />

Feedback<br />

To enable MFS to monitor the treatment<br />

experience at the unit patients may be asked to<br />

complete questionnaires. MFS welcomes all<br />

feedback - both positive and negative - which<br />

should be addressed to Anna Kavanagh,<br />

director of quality and business. <strong>Patients</strong>'<br />

experiences of MFS can help to improve the<br />

services offered.<br />

Complaints can be addressed to any member<br />

of the MFS team, who will pass on the<br />

comments to Anna Kavanagh in her role as<br />

complaints officer. Any issues can then be<br />

investigated thoroughly and a summary of the<br />

investigation made available to the patient. A<br />

copy of the complaints procedure is available<br />

to all new patients and can be found via<br />

www.midlandfertility.com.<br />

www.midlandfertility.com<br />

Full details of all MFS's services, costs and<br />

commitment to patient care are available at<br />

www.midlandfertility.com.<br />

4 | <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong>


MFS In 2008-2009<br />

The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

MFS 'babies', patients and staff celebrate 21 years of MFS<br />

In 2008 MFS celebrated 21 years of providing<br />

fertility treatment to people in the <strong>Midland</strong>s<br />

and throughout the UK. In the same year the<br />

clinic achieved a clinical pregnancy rate from<br />

IVF and ICSI, for women under the age of 38,<br />

of 29.4% per cycle started and 40.1% per<br />

embryo transfer. The livebirth rate for IVF and<br />

ICSI treatments in 2007 for women under the<br />

age of 38 was 26.4% per cycle started and<br />

33.6% per embryo transfer. 340 babies were<br />

born in 2008 including MFS's first baby from a<br />

frozen blastocyst and the 4,000th baby<br />

following treatment at MFS.<br />

As well as achieving a livebirth rate per cycle<br />

started in 2007 for IVF and ICSI frozen embryo<br />

transfers of 35.6% for women under the age of<br />

38 (which is almost double the national<br />

average of 19.9%), embryologists in the MFS<br />

laboratory also achieved high success rates for<br />

blastocyst transfers in 2007, with a livebirth<br />

rate per transfer of 43.4%. With the elective<br />

single embryo transfer (eSET) policy MFS<br />

implemented in early 2009, such results will<br />

help to achieve the government target for<br />

reducing the number of multiple births<br />

following fertility treatment, while maintaining<br />

the pregnancy rate for singleton babies.<br />

More than 1,000 current and former patients<br />

and their babies, toddlers, children and<br />

teenagers joined MFS for the clinic's 21st<br />

celebrations in June 2008. Some of them<br />

appear in the commemorative picture on the<br />

front cover of this <strong>Patients</strong>' Guide to <strong>Services</strong>.<br />

Later in 2008 MFS brought vitrification to the<br />

West <strong>Midland</strong>s and further enhanced the<br />

<strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> | 5


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

the same friendly welcome and the same high<br />

standard of care - just more shades of blue!<br />

Lynsey Bissell, Caroline Price and Kathy Gargett<br />

model the new administration staff uniforms<br />

reputation of the egg freezing service. MFS is<br />

now able to offer both the 'slow-freeze'<br />

method, from which all the UK 'ice babies' from<br />

their mothers' own eggs, have been born so<br />

far, as well as the 'flash-freezing' technique<br />

which can increase the survival rates of the<br />

eggs after thawing from 65% to 95%.<br />

Following the expansion of the unit to a second<br />

floor of Centre House in early 2007, the<br />

remodelling of MFS continued through 2008<br />

and 2009, with two new treatment rooms and<br />

a new nurses' station. It's part of a<br />

commitment to ensure that MFS has the<br />

facilities, staff, experience and skills capable of<br />

delivering more than 900 IVF cycles per year,<br />

while providing both highly-personalised<br />

treatment and a comfortable environment for<br />

every patient.<br />

Throughout the year MFS met the challenges<br />

of the 'fertility regulator', the hospitals'<br />

watchdog, and the quality management<br />

assessor, by satisfactorily completing internal<br />

or external audits from the HFEA, the<br />

Healthcare Commission, which has since been<br />

replaced by the Care Quality Commission and<br />

the BSI. By meeting these rigorous<br />

requirements and providing excellent patient<br />

care, MFS constantly strives to improve the<br />

service it provides to its patients.<br />

In January 2009 a very special MFS 'baby'<br />

popped into Centre House on a very special<br />

day. Michael Robinson is MFS's first baby<br />

born from a frozen embryo and he made a<br />

return visit to the unit on his 18th birthday. He<br />

met Heidi Birch, director of nursing services,<br />

who was involved in his parents' treatment in<br />

MFS staff also received a 'makeover' with the<br />

introduction of uniforms for the nursing and<br />

business support teams. The new look offers<br />

MFS's first frozen embryo transfer baby was 18 in<br />

January 2009. Michael Robinson pictured with (l-r):<br />

Heidi Birch, Dr Gillian Lockwood and Su Barlow<br />

6 | <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong>


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

1990 and he also observed laboratory<br />

manager Jo Johnson freezing newly-created<br />

embryos in liquid nitrogen tanks - just as ‘his’<br />

embryo had been preserved all those years<br />

ago!<br />

In March 2009 the first phase of the data<br />

management system (DMS) went 'live' with<br />

the conversion of more than 17,000 patient<br />

records to the new database. The launch of<br />

the electronic diary linked to the finance<br />

activity in September completed phase two of<br />

the DMS. Planning for the final phase of the<br />

DMS implementation continues when all<br />

current patient notes will be converted from<br />

hard-copies to computer data and all new<br />

patient notes will be held electronically rather<br />

than in paper format. The DMS ensures<br />

business security and continuity of care, even<br />

in the event of a serious incident, as the data<br />

is not stored exclusively at Centre House and<br />

could be accessed by MFS from any location.<br />

On-going investment in new technology<br />

included the introduction of an electronic<br />

witnessing system which generates a unique<br />

barcode for every patient that is applied to all<br />

dishes, tubes and sample pots which contain<br />

their gametes, embryos or blood. Whenever<br />

these samples are used, the barcode is<br />

scanned and matched against the patient's<br />

notes before the next stage of the procedure,<br />

providing reassurance to both patients and<br />

staff.<br />

In June 2009, MFS welcomed two very special<br />

MFS clinical midwife Beth Elton with her husband<br />

Thomas and their MFS ICSI twins Barney and Toby<br />

babies. Toby and Barney were born to Beth<br />

and Thomas Elton after ICSI treatment at MFS<br />

and following two failed cycles at another clinic<br />

- which Beth underwent while continuing her<br />

role as a clinical midwife at MFS and sharing<br />

the highs and lows of her patients' treatments<br />

while she was experiencing her own 'fertility<br />

journey'. It's a dream come true for Beth and<br />

Thomas and another wonderful 'Made in<br />

Aldridge' story.<br />

Finally, in June MFS relaunched<br />

www.midlandfertility.com, including<br />

comprehensive details of all investigations,<br />

treatments and preservation services, as well<br />

as advice on preparing for treatment, staff<br />

profiles, news, summarised and detailed<br />

success rates and the unique Cost Estimator©<br />

to give patients a clear idea of the true cost of<br />

any proposed treatment. For more information<br />

about any of the services included in the<br />

<strong>Patients</strong>' Guide to <strong>Services</strong>, visit<br />

www.midlandfertility.com.<br />

<strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> | 7


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

<strong>Services</strong> at MFS<br />

MFS offers a comprehensive range of<br />

investigations and treatments for male and<br />

female sub-fertility and fertility preservation<br />

services and also diagnostic tests for recurrent<br />

miscarriage.<br />

The clinical team includes consultant<br />

gynaecologists and doctors, as well as nurses<br />

and clinical midwives who have chosen to<br />

specialise in fertility medicine after graduating<br />

or after many years of general nursing or<br />

midwifery. Working closely with the doctors,<br />

they all have a variety of extended skills,<br />

including ultrasound scanning, IUI<br />

insemination, egg collection, embryo transfer<br />

and surgical sperm retrieval. This skills mix<br />

makes some of them the most highly trained<br />

and experienced fertility nurses and midwives<br />

in the world.<br />

The following pages provide a brief overview of<br />

the most frequently used services and<br />

treatments MFS offers, plus cumulative<br />

statistics for the period January 2005 to<br />

December 2007, including live birth rates, and<br />

for January to December 2008, showing<br />

recent pregnancy rates.<br />

For more detailed information on treatments,<br />

please request the appropriate MFS treatment<br />

information booklet available from reception,<br />

by asking a member of the team, or<br />

as a downloaded PDF file from<br />

www.midlandfertility.com.<br />

8 | <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong>


Getting Started<br />

The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

The first step in any fertility treatment is to identify<br />

and understand the reasons why pregnancy has not<br />

occurred naturally. MFS divides this diagnosis<br />

process into several stages:<br />

● initial consultation<br />

● treatment assessment<br />

● counselling<br />

● follow-up and treatment planning<br />

Initial consultation<br />

At their first appointment at MFS every<br />

patient meets the doctor, fertility nurse<br />

specialist or midwife who will be one of their<br />

contacts during treatment. They will:<br />

● take a full medical history and ask about<br />

lifestyle issues<br />

● explain the legislative framework that<br />

MFS works within<br />

● answer any questions<br />

Treatment assessment<br />

To plan treatment effectively, MFS will need to<br />

perform certain tests, which may duplicate others<br />

a patient may have had elsewhere, including:<br />

● baseline hormones (FSH and LH).<br />

Normally tested on day two to five or<br />

possibly up to day six if in conjunction with<br />

ORT (see page 11)<br />

● vaginal pelvic ultrasound scan<br />

● blood tests for routine infection screening<br />

(HIV, hepatitis B and hepatitis C) - a<br />

requirement for all patients having licensed<br />

fertility treatment<br />

● sperm analysis<br />

Counselling<br />

Counselling support is provided by members of<br />

the clinical team and also by fertility<br />

counsellors. This service is available before,<br />

during and after treatment and is included in<br />

the costs for as long as it relates to treatment<br />

at MFS.<br />

Occasionally MFS may be unable to proceed<br />

with treatment until a patient has seen an<br />

independent counsellor. This may be because<br />

of the type of required treatment or because<br />

there is an issue that needs discussing before<br />

treatment can be offered. The counsellor will<br />

only advise MFS that they have seen the<br />

patient and all issues remain confidential<br />

unless the patient agrees disclosure;<br />

counselling is not part of the assessment for<br />

treatment.<br />

The counselling advice line 01332 694622, is<br />

available everyday of the year between<br />

9.00am and 10.00pm.<br />

Follow-up and treatment planning<br />

Using the information gathered from the initial<br />

consultation, tests and investigations, MFS<br />

can recommend the appropriate treatment for<br />

each patient. These options will be discussed<br />

in full, including any risks and also the success<br />

rates. At this visit, treatment may be planned<br />

immediately, or the clinical team may advise<br />

that more advanced tests and investigations<br />

are needed.<br />

Whatever is decided, the patient will leave this<br />

appointment knowing what they need to do<br />

next to begin treatment.<br />

<strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> | 9


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

Investigations<br />

MFS offers a comprehensive range of<br />

diagnostic tests and investigations for male<br />

and female sub-fertility and recurrent<br />

pregnancy loss. For about 30% of couples<br />

trying to conceive, more than one problem<br />

contributes to their infertility. Even if a couple<br />

is aware of a factor such as tubal blockage or<br />

low sperm count, additional tests will reveal<br />

another problem for about 30% of couples<br />

whose infertility is investigated further - and<br />

pregnancy may not be possible until both<br />

problems are addressed.<br />

<strong>Fertility</strong> Investigation Package<br />

The <strong>Fertility</strong> Investigation Package (FIP) is a<br />

comprehensive investigation of both male and<br />

female partners for the most common causes<br />

of infertility. It offers more thorough testing<br />

than home-test kits and also includes<br />

ultrasound scans and counselling.<br />

●<br />

●<br />

●<br />

●<br />

measurement of male and female<br />

hormones<br />

ovarian reserve testing<br />

a sperm analysis<br />

a review of the test results and a<br />

discussion of future options<br />

Who can benefit from the FIP?<br />

● couples who have been trying to conceive<br />

for some time (typically after two years<br />

where the woman is under 35 years old, or<br />

after one year if the woman is 35+)<br />

What is included in the cost?<br />

● initial consultation<br />

● counselling (if appropriate)<br />

● an ultrasound scan<br />

How long do the tests take?<br />

The FIP may require two or more appointments<br />

at MFS in a month.<br />

Results<br />

Results may either identify treatable problems<br />

which may prevent pregnancy or reassure<br />

some couples that they have a good chance of<br />

conceiving naturally.<br />

10 | <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> : Investigations


Measuring a woman's ovarian reserve may<br />

provide vital information about whether she<br />

can 'safely' defer trying for a baby for a few<br />

years or whether her 'reproductive life span' is<br />

so low that she should not delay. The<br />

measurement of anti-Müllerian hormone<br />

(AMH) as a predictor of ovarian response to<br />

stimulation with hormones during fertility<br />

treatment gives an accurate indication of a<br />

woman's spontaneous fertility potential and<br />

her response to fertility stimulation drugs.<br />

The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

Ovarian Reserve Test (ORT)<br />

Over-the-counter fertility testing kits may<br />

provide similar results to the MFS ORT, but will<br />

not be as comprehensive and do not include an<br />

ultrasound scan, an explanation of the results<br />

by a fertility specialist, or offer any counselling.<br />

Who can benefit?<br />

● any woman who wants to assess her<br />

fertility potential who is planning to<br />

conceive either naturally or with fertility<br />

treatment<br />

● any woman interested in elective egg<br />

freezing (see pages 30-31) is required to<br />

undergo an ORT at MFS a maximum of 12<br />

months before progressing to the egg<br />

freezing preparation service<br />

What does the test involve?<br />

In addition to measuring AMH to help gauge a<br />

woman's fertility potential, the MFS ORT also<br />

includes: an assessment of LH and FSH<br />

hormones, a single consultation with a fertility<br />

specialist, an ovarian ultrasound scan which<br />

may indicate problems which can reduce the<br />

chance of spontaneous pregnancy and<br />

counselling, where appropriate.<br />

How long does the test take?<br />

The blood test should be taken on day two to<br />

five of the woman's cycle and the results may<br />

be known within two to four weeks of the blood<br />

test.<br />

Results<br />

The interpretation of the woman's ovarian<br />

reserve includes assessment of the hormone<br />

test results, the scan, her age and lifestyle and<br />

also of her fertility and medical histories.<br />

Results are given at a single consultation<br />

combined with an ultrasound scan on day two<br />

to six of the woman’s cycle.<br />

Investigations : <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> | 11


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

Recurrent Miscarriage Service<br />

Who can benefit?<br />

● any woman who has experienced two or<br />

more miscarriages, whether she conceived<br />

naturally or after fertility treatment<br />

● the woman does not have to be an existing<br />

patient of MFS<br />

● a woman may 'self-refer' - a doctor's<br />

referral is not necessary<br />

The recurrent miscarriage service at MFS<br />

seeks to identify any treatable causes of<br />

miscarriage and to offer early diagnosis and<br />

appropriate management by a dedicated team<br />

of the MFS clinical staff. To maximise the<br />

convenience to the patient, blood tests may be<br />

sent to her to be completed at her GP surgery.<br />

Miscarriage occurs in about 10-15% of all<br />

pregnancies and increases with the age of any<br />

woman trying to conceive. Recurrent<br />

miscarriage - or recurrent pregnancy loss<br />

(RPL) - is defined as the loss of three or more<br />

pregnancies and affects 1% of all women.<br />

However, even after a number of miscarriages,<br />

a successful pregnancy remains possible. The<br />

specialised tests at the MFS recurrent<br />

miscarriage service may help to identify<br />

specific problems and treatments may be able<br />

to prevent future pregnancy losses.<br />

What is included in the service?<br />

Initial investigations include:<br />

● medical history and examination, including<br />

a BMI assessment<br />

● karyotype blood test (both partners) for<br />

genetic abnormalities, the problem for<br />

about 3-5% of couples with RPL<br />

● anti-phospholipid antibodies blood test - a<br />

high level of anti-phospholipid antibodies is<br />

the cause of miscarriage in about 15% of<br />

women with RPL<br />

● FSH and LH hormone blood test<br />

● ultrasound scan to identify any<br />

abnormalities of the uterus or ovaries<br />

● follow-up consultation<br />

● counselling<br />

● following any positive pregnancy test, an<br />

early pregnancy ultrasound at six weeks<br />

gestation<br />

Additional investigations which may also be<br />

required are also available.<br />

Results<br />

Not all causes of RPL can be treated, but<br />

certain treatments, specifically for<br />

thrombophilias can be very effective.<br />

12 | <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> : Investigations


Private Sperm Analysis<br />

Male factor infertility accounts for about 35%<br />

of infertility and a seminal fluid analysis (SFA)<br />

is a comprehensive way to assess if any<br />

difficulty in conceiving is related to a problem<br />

with sperm. A private sperm analysis at MFS:<br />

● assesses the volume, concentration,<br />

motility (movement) and morphology<br />

(shape) of the sperm<br />

● measures the number of white blood cells,<br />

antisperm antibodies and the Ph balance<br />

of the sample<br />

The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

No doctor referral is required. A private sperm<br />

analysis at MFS requires only one two-hour<br />

appointment and the results are available the<br />

same day.<br />

Who may benefit?<br />

Any man who has been actively trying to<br />

conceive with his partner for up to 12 months<br />

and is not aware of any reasons which could<br />

prevent this from occurring.<br />

What does the test involve?<br />

Guidance about providing the sample will be<br />

given once the appointment is confirmed. After<br />

analysing the sample at MFS, an embryologist<br />

will give the man:<br />

● the results of the analysis<br />

● observations on a comparison with a<br />

'normal' semen analysis<br />

● advice on the probability of his sperm<br />

achieving either a natural pregnancy, or<br />

whether fertility treatment such as IVF or<br />

ICSI is recommended<br />

What is included in the cost?<br />

● the laboratory analysis of the sperm<br />

sample<br />

● a same-day follow-up appointment with a<br />

member of the laboratory staff to report<br />

the results<br />

● a copy of the report detailing the results<br />

Freezing or storage of any sperm sample, or<br />

any other investigations or treatments are not<br />

included in the cost.<br />

How long does the test take?<br />

Allow about two hours for the single<br />

appointment to provide the sample, the<br />

laboratory analysis of the sample and the<br />

follow-up appointment with a member of the<br />

laboratory team for the results.<br />

Investigations : <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> | 13


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

Treatments and Procedures<br />

Following an initial consultation and treatment<br />

assessment, the MFS clinical and scientific<br />

teams will have all the information needed to<br />

advise a patient on whether fertility treatment<br />

is necessary and if so, what type is<br />

recommended for a specific woman or couple.<br />

All fertility preservation and treatment plans at<br />

MFS are tailor-made to maximise the chance of<br />

success for each individual patient. The<br />

following information outlines the main<br />

treatments offered by MFS.<br />

Intrauterine Insemination (IUI)<br />

Intrauterine insemination (IUI) involves placing<br />

carefully prepared sperm directly into the<br />

uterus, close to the time an egg is released<br />

(ovulation). IUI is one of the simplest and least<br />

invasive fertility treatments.<br />

Who may benefit?<br />

● women who have at least one healthy<br />

Fallopian tube, to allow the sperm and egg<br />

to meet and for fertilisation to occur<br />

● women with cervical mucus problems<br />

which may prevent sperm from entering<br />

the uterus<br />

● couples with 'unexplained infertility'<br />

● women having treatment with donor sperm<br />

IUI is not suitable for women with damaged<br />

Fallopian tubes or for men with very poor<br />

quality sperm.<br />

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The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

What does treatment involve?<br />

●<br />

●<br />

●<br />

●<br />

most IUIs at MFS are carried out during a<br />

woman's natural cycle, where only one egg<br />

is usually produced, so reducing the risk of<br />

a multiple pregnancy<br />

women who do not ovulate regularly are<br />

given fertility drugs to stimulate their<br />

ovaries to produce more than one egg and<br />

ultrasound scans are used to predict the<br />

day on which the egg is released. A<br />

hormone injection may be given to initiate<br />

ovulation, or to boost the natural LH surge,<br />

allow to more accurate timing of ovulation<br />

and to increase the probability of<br />

pregnancy<br />

only highly motile (active) partner or donor<br />

sperm is placed into the uterus via a fine<br />

plastic catheter, passed through the cervix<br />

a pregnancy test may be done 14 days<br />

after IUI insemination<br />

What is included in the cost?<br />

● monitoring scans, preparation of the<br />

sperm, IUI procedure, pregnancy test and<br />

scan and/or follow-up to review the<br />

treatment cycle<br />

The fee for freezing sperm and/or for donor<br />

sperm (if required) and the HFEA levy for using<br />

donor sperm are not included in the cost.<br />

How long does treatment take?<br />

An average of four to five weeks from the<br />

beginning of the treatment cycle to pregnancy<br />

test.<br />

Donor treatments and the law<br />

For information on donor conceived children,<br />

donor identification and the law see page 23<br />

and also visit the donor treatments section of<br />

www.midlandfertility.com.<br />

Results<br />

IUI: January - December 2008<br />

Age All<br />

Partner Donor Total<br />

≤35 36-39 ≥40 All ≤35 36-39 ≥40<br />

Number of inseminations 66 29 33 4 48 26 14 8 114<br />

Pregnancy rate (%) 12.1 13.8 9.1 25.0 16.7 19.2 7.1 25.0 14.0<br />

IUI: January 2005 - December 2007<br />

Age All<br />

Partner Donor Total<br />

≤35 36-39 ≥40 All ≤35 36-39 ≥40<br />

Number of inseminations 306 181 68 57 430 221 128 81 736<br />

Livebirth rate (%) 10.8 14.4 8.8 1.8 12.8 15.4 13.3 4.9 12.0<br />

Treatments and Procedures : <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> | 15


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

In Vitro Fertilisation (IVF)<br />

In vitro fertilisation (IVF) literally means<br />

fertilisation 'in glass'. Instead of the sperm<br />

fertilising the egg within the body (in vivo),<br />

fertilisation takes place in a sterile dish (in<br />

vitro) in a laboratory.<br />

IVF has been available in the UK since 1978<br />

and since then, more than four million babies<br />

have been born worldwide following IVF<br />

treatment.<br />

Who may benefit?<br />

● women with blocked Fallopian tubes<br />

● men and women with 'unexplained infertility'<br />

● men with moderately poor sperm function<br />

IVF is not suitable for couples where the man<br />

has poor quality sperm or no sperm at all<br />

(azoospermia).<br />

Almost 2,000 babies have<br />

been born after IVF<br />

treatment at MFS<br />

What does treatment involve?<br />

● daily injections or a nasal spray 'down<br />

regulate' the woman's usually monthly<br />

cycle to a temporary menopausal state,<br />

before daily injections of gonadotrophin<br />

drugs stimulate the ovaries to produce<br />

more eggs than occur in a natural cycle.<br />

The dose of drugs is carefully calculated to<br />

optimise the chance of pregnancy for each<br />

patient<br />

● regular ultrasound scans monitor the<br />

number and size of the growing follicles.<br />

When these have grown sufficiently the<br />

patient is advised of the day of her egg<br />

collection (usually about two weeks after<br />

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The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

●<br />

●<br />

●<br />

●<br />

she first starts taking the stimulating<br />

drugs)<br />

egg collection is performed with ultrasound<br />

guidance under conscious sedation and<br />

with pain relief<br />

where partner sperm is to be used, the<br />

sample must be produced at the clinic<br />

immediately before egg collection<br />

IVF using the standard insemination<br />

technique needs approximately 150,000<br />

good quality sperm for each egg. The<br />

inseminated eggs are placed in an<br />

incubator and checked the following<br />

morning for signs of normal fertilisation<br />

the fertilised eggs (embryos) are cultured<br />

before the embryo transfer, two to six<br />

days after fertilisation, where one or two<br />

of the best quality embryos are placed into<br />

the uterus<br />

● any remaining good quality embryos can<br />

be frozen and stored for any future<br />

attempts to conceive<br />

● a pregnancy test may be done up to 14<br />

days after the IVF embryo transfer<br />

What is included in the cost?<br />

Treatment planning, monitoring scans,<br />

teaching how to give injections, egg collection,<br />

sperm preparation, fertilisation of eggs,<br />

embryo transfer, freezing of embryos and<br />

storage for first year, pregnancy test and six<br />

week dating scan and/or follow-up to review<br />

the treatment cycle.<br />

How long does treatment take?<br />

An average of five to eight, weeks from the<br />

beginning of the treatment cycle to pregnancy<br />

test, depending on the drug protocol.<br />

Results<br />

IVF: January - December 2008<br />

Age All ≤35 36-39 ≥40<br />

Total cycles 407 207 126 74<br />

Pregnancy rate per cycle started (%) 26.8 31.4 24.6 17.6<br />

Pregnancy rate per embryo transfer (%) 36.5 43.6 31.3 25.5<br />

IVF: January 2005 - December 2007<br />

Age All ≤35 36-39 ≥40<br />

Total cycles 1089 600 326 163<br />

Livebirth rate per cycle started (%) 22.0 25.5 23.0 7.4<br />

Livebirth rate per embryo transfer (%) 27.7 31.9 27.8 10.2<br />

Treatments and Procedures : <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> | 17


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

Intra Cytoplasmic Sperm<br />

Injection (ICSI)<br />

Intra cytoplasmic sperm injection (ICSI)<br />

involves the injection of a single healthy sperm<br />

into the cytoplasm - the jelly-type middle - of<br />

an egg. IVF using the standard insemination<br />

technique requires approximately 150,000<br />

sperm for each egg, but ICSI requires just one<br />

good quality sperm per egg.<br />

MFS introduced ICSI to the West <strong>Midland</strong>s in<br />

1994 and it has greatly improved the prospects<br />

of parenthood for many couples with specific<br />

fertility problems, particularly male factor<br />

infertility.<br />

Who may benefit?<br />

● men with poor quality sperm<br />

● men who have had surgical sperm retrieval<br />

because they are azoospermic<br />

●<br />

●<br />

couples with previous fertilisation failure<br />

from standard IVF insemination<br />

women using thawed/frozen eggs<br />

More than 2,000 babies have<br />

been born following ICSI<br />

treatment at MFS<br />

What does treatment involve?<br />

● the first part of the process is the same as<br />

for IVF, when fertility drugs are used to<br />

down regulate and then stimulate the<br />

ovaries to allow several eggs to be<br />

collected during the egg collection<br />

procedure (see IVF, pages 16 - 17)<br />

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The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

●<br />

●<br />

●<br />

around the time of the egg collection an<br />

embryologist prepares the sperm for ICSI.<br />

This may be taken from a sample produced<br />

earlier that day, or from a frozen sample,<br />

or from a small sample of tissue (a biopsy)<br />

taken from the testis (see Surgical Sperm<br />

Retrieval, pages 20-21). The best quality<br />

sperm are isolated and incubated until it is<br />

time for the ICSI procedure<br />

after egg collection, the eggs are<br />

examined by the embryologist to check<br />

they are mature and suitable for sperm<br />

injection. A single sperm with the best<br />

shape and swimming-ability is selected<br />

and, under a microscope, using a glass<br />

needle finer than a human hair, is injected<br />

into the centre of the egg<br />

the injected eggs are placed in an<br />

incubator and checked the next morning<br />

for signs of successful fertilisation - when<br />

they become embryos<br />

● embryos are transferred to the uterus two<br />

to six days after the ICSI sperm injection<br />

● good quality embryos which are not<br />

transferred may be frozen for later use<br />

● a pregnancy test may be done up to 14<br />

days after the embryo transfer to confirm<br />

if the treatment has been successful<br />

What is included in the cost?<br />

Treatment planning, monitoring scans,<br />

teaching how to give injections, egg collection,<br />

sperm preparation, ICSI injection of eggs,<br />

embryo transfer, freezing and storage of<br />

embryos for first year, pregnancy test and six<br />

week dating scan and/or follow-up to review<br />

the treatment cycle.<br />

How long does treatment take?<br />

An average of five to eight weeks from the<br />

beginning of the treatment cycle to pregnancy<br />

test, depending on the drug protocol.<br />

Results<br />

ICSI: January - December 2008<br />

Age All ≤35 36-39 ≥40<br />

Total cycles 391 221 122 48<br />

Pregnancy rate per cycle started (%) 26.1 30.8 23.0 12.5<br />

Pregnancy rate per embryo transfer (%) 35.8 41.0 31.8 19.4<br />

ICSI: January 2005 - December 2007<br />

Age All ≤35 36-39 ≥40<br />

Total cycles 1139 647 342 150<br />

Livebirth rate per cycle started (%) 22.5 25.5 23.7 6.7<br />

Livebirth rate per embryo transfer (%) 27.7 31 28.3 8.8<br />

Treatments and Procedures : <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> | 19


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

Surgical Sperm Retrieval (SSR)<br />

About one man in a hundred produces no<br />

sperm in his semen (azoospermia). This might<br />

be due to a vasectomy (the male sterilisation<br />

operation), illness, trauma or a genetic<br />

condition. For some men with these problems,<br />

it may be possible to surgically retrieve sperm<br />

directly from the testes for MFS scientific staff<br />

to achieve fertilisation of an egg with ICSI (see<br />

pages 18-19).<br />

Who may benefit?<br />

● men who have had a vasectomy or failed<br />

vasectomy reversal<br />

● men who are carriers of certain genetic<br />

conditions, for example Cystic Fibrosis<br />

● men who do not produce sperm in their<br />

semen, for example in cases of retrograde<br />

ejaculation<br />

In 2008, for women less than<br />

35, using surgically retrieved<br />

sperm with ICSI, MFS<br />

achieved a pregnancy rate<br />

per embryo transfer of 55.6%<br />

What does treatment involve?<br />

An SSR is usually planned in advance but in<br />

exceptional circumstances can also be carried out<br />

as an emergency procedure if the man is unable<br />

to produce a sperm sample on the day of his<br />

wife's or partner's egg collection. Under sedation<br />

and with pain relief, a clinical team led by an MFS<br />

doctor or nurse may use two different methods to<br />

surgically retrieve sperm:<br />

20 | <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> : Treatments and Procedures


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

●<br />

●<br />

PESA is the least invasive method and<br />

involves inserting a fine needle into the<br />

epididymis, the convoluted tube that<br />

leaves the testis to become the vas<br />

deferens. It is suitable for men who have<br />

had a vasectomy, or who were born<br />

without a vas deferens<br />

TESA involves passing the needle directly<br />

into the testis to remove a small core of<br />

tissue, which is then prepared by scientists<br />

to release the developing sperm<br />

the female patient may start her fertility<br />

treatment knowing that enough sperm is<br />

available to use with the ICSI procedure.<br />

What is included in the cost?<br />

● treatment planning<br />

● sperm analysis<br />

● surgical sperm retrieval procedure<br />

The costs of the initial consultation, treatment<br />

assessment, ICSI and freezing and storage are<br />

additional.<br />

Samples are passed immediately to the MFS<br />

laboratory where a scientist checks them for<br />

sperm suitable for use in ICSI. Once enough<br />

are identified, the procedure is stopped.<br />

Surgically retrieved sperm may be frozen, so<br />

How long does treatment take?<br />

SSR is a one hour procedure and the<br />

appointment may be confirmed after<br />

satisfactory routine infection screening.<br />

Results<br />

Surgical Sperm Recovery with ICSI: January - December 2008<br />

Age All ≤35 36-39 ≥40<br />

Total cycles 53 25 17 11<br />

Pregnancy rate per cycle started (%) 32.1 40.0 29.4 18.2<br />

Pregnancy rate per embryo transfer (%) 38.6 55.6 33.3 18.2<br />

Surgical Sperm Recovery with ICSI: January 2005 - December 2007<br />

Age All ≤35 36-39 ≥40<br />

Total cycles 174 97 51 26<br />

Livebirth rate per cycle started (%) 18.4 18.6 27.5 0<br />

Livebirth rate per embryo transfer (%) 22.4 23.1 33.3 0<br />

Treatments and Procedures : <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> | 21


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

Egg Sharing and Donation<br />

●<br />

●<br />

●<br />

●<br />

age<br />

premature menopause<br />

ovarian failure<br />

a risk of passing on hereditary diseases<br />

Egg sharing is not suitable for everyone and<br />

there are many issues to consider. Donor egg<br />

sharers are women who meet certain age,<br />

lifestyle and clinical criteria who may benefit<br />

from IVF or ICSI treatment. The MFS policy<br />

for selecting egg sharers ensures that the<br />

donor's chances of becoming pregnant are not<br />

lowered and that the recipient has the best<br />

possible chance of conceiving.<br />

MFS actively coordinates the donation and<br />

receipt of donor eggs via the egg share and<br />

egg donor service. Women who require donor<br />

eggs for their fertility treatment may receive<br />

them either from an altruistic egg donor or<br />

from another woman who is willing to donate<br />

some of the eggs produced during her fertility<br />

treatment. For women willing to share their<br />

eggs, the egg sharing scheme can help other<br />

people have fertility treatment, as well as help<br />

to fund their own IVF or ICSI treatment. For<br />

more extensive information for egg sharers,<br />

donors and recipients visit the egg sharing and<br />

donor treatments pages of<br />

www.midlandfertility.com.<br />

Who may benefit?<br />

Women may require donor eggs for reasons<br />

including:<br />

What does treatment involve?<br />

● egg donors and sharers have essentially<br />

the same procedure as IVF patients (see<br />

IVF, pages 16-17). Fertilisation for egg<br />

sharers follows with either IVF or ICSI, as<br />

required (see pages 16 -19)<br />

● egg recipients receive drugs to coincide<br />

with the donor's cycle, monitoring scans<br />

and the fertilisation of the allocated eggs,<br />

followed by an embryo transfer<br />

What is included in the cost?<br />

● there are no costs to altruistic egg donors<br />

and they may be compensated for their<br />

travel and some other expenses. Altruistic<br />

egg donors receive: monitoring scans,<br />

teaching of how to give injections, egg<br />

recovery and a follow-up consultation<br />

● egg sharers receive: monitoring scans,<br />

teaching of how to give injections, egg<br />

recovery, fertilisation of up to half the<br />

22 | <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> : Treatments and Procedures


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

●<br />

eggs collected, embryo transfer, storage of<br />

frozen embryos for first year, pregnancy<br />

test, scan and/or follow-up to review the<br />

treatment cycle<br />

egg recipients receive: monitoring scans,<br />

fertilisation of the allocated eggs, embryo<br />

transfer, storage of frozen embryos for<br />

first year, pregnancy test, scan and/or<br />

follow-up to review the treatment cycle<br />

How long does treatment take?<br />

Screening a donor and matching a recipient<br />

usually takes up to four weeks. For altruistic<br />

donors, treatment takes an average of five to<br />

six weeks from the beginning of the treatment<br />

cycle to egg collection. Treatment for egg<br />

sharers and egg recipients takes about eight to<br />

10 weeks from the beginning of the cycle to<br />

pregnancy test.<br />

The law and donor sperm, eggs and<br />

embryos<br />

In 2005 the law regarding donor anonymity<br />

changed so that any child conceived after 1<br />

April 2006 from donor sperm, eggs or embryos<br />

from donors registered after 1 April 2005 will be<br />

able, on reaching the age of 18 - or sooner if<br />

they are to marry - to access identifying<br />

information about the donor. This has reduced<br />

the number of available donors and had a<br />

severe impact on donor services throughout the<br />

UK. Any concerns about the implications of the<br />

removal of donor anonymity can be discussed<br />

with MFS staff or a counsellor. For more<br />

information about donor identification and the<br />

law visit the 'donor treatments' pages of<br />

www.midlandfertility.com.<br />

Results<br />

IVF & ICSI for Egg Share Donors & Recipients: January - December 2008<br />

Five cycles resulted in two clinical pregnancies for the donors and three clinical pregnancies for<br />

the recipients<br />

IVF & ICSI for Egg Share Donors: January 2005 - December 2007<br />

All IVF ICSI<br />

Total cycles 67 37 30<br />

Livebirth rate per cycle started (%) 14.9 18.9 10.0<br />

Livebirth rate per embryo transfer (%) 19.6 22.6 15.0<br />

IVF & ICSI for Egg Share Recipients: January 2005 - December 2007<br />

Total IVF ICSI<br />

Total cycles 67 38 29<br />

Livebirth rate per cycle started (%) 34.3 34.2 34.5<br />

Livebirth rate per embryo transfer (%) 39.0 38.2 40.0<br />

Treatments and Procedures : <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> | 23


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

Embryo Freezing, Thawing<br />

and Transfer<br />

extended from five to up to 10 years and may<br />

be increased further in exceptional<br />

circumstances. Some MFS patients have had<br />

babies more than 10 years after their embryos<br />

were originally created and frozen.<br />

Embryos can be stored at an extremely low<br />

temperature (-196˚C) to suspend their<br />

development. Once frozen, embryos can<br />

remain in liquid nitrogen for many years<br />

without deterioration before being thawed and<br />

used in treatment.<br />

Freezing good quality embryos offers a chance<br />

of conceiving either after an unsuccessful<br />

fresh embryo transfer, or following a<br />

successful transfer and pregnancy. Using<br />

thawed frozen embryos gives the possibility of<br />

a brother or sister for a patient's baby from a<br />

single cycle of IVF or ICSI treatment.<br />

Legislation determines the time that MFS,<br />

with patient consent, is allowed to store<br />

embryos. On 1 October 2009 this was<br />

Where other clinics may<br />

charge an additional fee for<br />

all embryo storage, the cost<br />

of embryo freezing and one<br />

year's storage at MFS is<br />

included in the fees for all<br />

treatments involving IVF<br />

and ICSI.<br />

MFS contacts patients every year to make<br />

sure they wish the clinic to continue storing<br />

their embryos and so it is vital that MFS is<br />

updated about any patient change of address<br />

while embryos remain in storage.<br />

Who may benefit?<br />

● following a fresh embryo transfer, good<br />

quality surplus embryos created during IVF<br />

or ICSI treatment may be frozen and<br />

stored for the patients' future use<br />

● following egg collection for IVF or ICSI<br />

treatment, patients who have been<br />

advised not to go ahead with a fresh<br />

embryo transfer will have their embryos<br />

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The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

●<br />

frozen for use in treatment at a later date<br />

as a fertility preservation option, a woman<br />

in a relationship who has a medical<br />

condition or who requires medical<br />

treatment that may make her prematurely<br />

infertile, can have embryos created and<br />

frozen to give her the chance of having<br />

children with her current partner at a later<br />

date<br />

What does treatment involve?<br />

● most thawed/frozen embryos are replaced<br />

in the uterus in a natural cycle, which<br />

eliminates the need to take fertility drugs<br />

● sometimes the patient may require<br />

hormone tablets to improve her<br />

endometrium, particularly if her menstrual<br />

cycle is irregular or an adequate uterine<br />

lining cannot be achieved naturally<br />

● before embryos can be frozen, both<br />

partners will be asked to complete a form<br />

consenting to the storage of the embryos.<br />

This is an important legal requirement, so<br />

it is essential that both partners advise<br />

MFS immediately of any change in their<br />

circumstances or their address while<br />

embryos remain in storage<br />

What is included in the cost?<br />

● monitoring scans before the embryo<br />

transfer, thawing and monitoring of<br />

embryos in the lab, embryo transfer and<br />

pregnancy test and scan and/or follow-up<br />

to review the treatment cycle<br />

● the initial cost of embryo freezing and one<br />

year's storage is included in the original<br />

IVF or ICSI treatment fee<br />

How long does treatment take?<br />

See pages 17 and 19 for details of the time<br />

required for IVF and ICSI treatments. The thaw<br />

and transfer of frozen embryos requires an<br />

average of four to five weeks from the start of<br />

the treatment cycle to pregnancy test.<br />

Results<br />

Frozen Embryo Transfers: January - December 2008<br />

Age All ≤35 36-39 ≥40<br />

Total cycles 211 136 53 22<br />

Pregnancy rate per cycle started (%) 28.9 34.6 26.4 0.0<br />

Pregnancy rate per embryo transfer (%) 31.0 36.7 29.2 0.0<br />

Frozen Embryo Transfers: January 2005 - December 2007<br />

Age All ≤35 36-39 ≥40<br />

Total cycles 590 370 138 82<br />

Livebirth rate per cycle started (%) 27.8 31.9 23.9 15.9<br />

Livebirth rate per embryo transfer (%) 30.3 33.6 27.5 18.3<br />

Treatments and Procedures : <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> | 25


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

Surrogacy<br />

●<br />

couples for whom pregnancy is clinically<br />

inadvisable<br />

MFS offers host surrogacy treatment, where<br />

the commissioning couple provide the embryos<br />

which have been created through IVF or ICSI<br />

and which are then placed in the uterus of the<br />

surrogate. Both the commissioning couple and<br />

the surrogate must be UK residents.<br />

Who may benefit?<br />

● couples for whom non-surrogate fertility<br />

treatments have failed<br />

Embryo Transfer Policy<br />

What does treatment involve?<br />

● both the commissioning couple and the<br />

surrogate receive extensive and separate<br />

consultations from different members of<br />

the clinical team to cover all the issues of<br />

surrogacy and the welfare interests of any<br />

current or future children<br />

● counselling is recommended<br />

What is included in the cost?<br />

Surrogacy may require IVF or ICSI, and<br />

possibly include the use of donor sperm, eggs<br />

or embryos and so a summary of the costs is<br />

not possible. Guidance on the cost for any<br />

individual couple is available at the initial<br />

consultation or at the follow-up appointment.<br />

To reduce the risk of multiple births, MFS<br />

adheres to the HFEA code on embryo transfers<br />

which was implemented in 2001 to achieve a<br />

balance between reducing multiple births and<br />

maximising a woman's chance of having a<br />

healthy baby. The Code makes a distinction<br />

based on age and states that in a single<br />

treatment cycle, a maximum of:<br />

● two embryos can be transferred to a<br />

woman of less than 40 years of age, with<br />

no exceptions<br />

●<br />

three embryos may be transferred to a<br />

woman aged 40 and over if she is using<br />

her own eggs<br />

In addition, MFS also adheres to the elective<br />

single embryo transfer (eSET) policy<br />

implemented by all fertility clinics in the West<br />

<strong>Midland</strong>s in January 2009 to reduce the<br />

number of IVF and ICSI multiple pregnancies in<br />

the UK to 10% by 2012. To achieve this, some<br />

patients will be offered only a single embryo<br />

transfer.<br />

26 | <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> : Treatments and Procedures


Blastocyst Transfer<br />

A blastocyst is an embryo which has<br />

developed into a multi-cellular mass five or six<br />

days after the sperm has fertilised the egg.<br />

Because a healthy blastocyst may have a<br />

greater chance of implanting, the pregnancy<br />

rate may be maintained even though fewer are<br />

replaced - so reducing the risk of a multiple<br />

pregnancy.<br />

The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

Who may benefit?<br />

Blastocyst transfer may be suitable for the<br />

following patients having IVF or ICSI:<br />

● those who are advised for medical reasons<br />

to avoid a twin pregnancy<br />

● those who would prefer to avoid a twin<br />

pregnancy for other reasons<br />

● those who meet the criteria for a single<br />

embryo transfer (eSET)<br />

● those who have had negative results after<br />

earlier embryo transfers<br />

What does treatment involve?<br />

● before IVF or ICSI egg collection, MFS<br />

staff will discuss the suitability of a<br />

blastocyst transfer with the patient<br />

●<br />

●<br />

a decision about blastocyst transfer is<br />

made three days after the egg collection<br />

fresh blastocysts are transferred five or six<br />

days after egg collection. Remaining<br />

blastocysts may be frozen and stored for<br />

possible future use<br />

What is included in the cost?<br />

There is no additional charge for blastocyst<br />

culture and transfer as part of IVF and ICSI<br />

treatment at MFS.<br />

How long does treatment take?<br />

Blastocyst transfer does not change the<br />

average length of treatment time for standard<br />

IVF or ICSI, or for frozen embryo transfer.<br />

Results<br />

Blastocyst Transfers: January - December 2008<br />

IVF FET ICSI Total<br />

Number of patients getting to blastocyst transfer 102 73 76 251<br />

Pregnancy rate per blastocyst transfer (%) 46.1 38.4 52.6 45.8<br />

Blastocyst Transfers: January 2006 - December 2007<br />

IVF FET ICSI Total<br />

Number of patients getting to blastocyst transfer 78 78 94 250<br />

Livebirth rate per embryo transfer (%) 38.5 50 45.7 44.8<br />

Treatments and Procedures : <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> | 27


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

Preservation <strong>Services</strong><br />

MFS offers a range of services for men and<br />

women who wish to 'preserve' their fertility by<br />

freezing and storing sperm, eggs or embryos<br />

for possible future use:<br />

● sperm collection and freezing (see below)<br />

● vasectomy reversal back-up plan (see page<br />

29)<br />

● egg freezing (see pages 30 - 31)<br />

● embryo freezing (see pages 24 - 25)<br />

Sperm Freezing<br />

elective reasons, including men who work<br />

in high-risk occupations, such as the<br />

military or any man whose sperm count is<br />

declining prematurely<br />

What does the procedure involve?<br />

●<br />

●<br />

●<br />

●<br />

a single consultation<br />

routine infection screening<br />

laboratory analysis of sperm<br />

freezing of viable sperm<br />

Sperm collection and freezing is a non-invasive<br />

and long-established procedure which has led<br />

to the birth of many thousands of babies,<br />

worldwide, following the thaw of the sperm and<br />

its use to achieve a pregnancy either through<br />

IUI, IVF or ICSI.<br />

Who may benefit?<br />

In addition to freezing sperm as part of a<br />

couple's fertility treatment, MFS is also able to<br />

freeze sperm to preserve a man's fertility. This<br />

may benefit:<br />

● men diagnosed with cancer or other<br />

medical conditions which require<br />

chemotherapy or radiotherapy treatment<br />

● men who wish to preserve their fertility for<br />

What is included in the cost?<br />

● routine infection screening, laboratory<br />

analysis and freezing of the sperm<br />

sample(s), storage of the sperm for the<br />

first year<br />

The costs of any surgical sperm retrieval, other<br />

investigations or treatments, or storage after<br />

the first year are not included.<br />

How long does treatment take?<br />

● for pre-medical treatment sperm freezing;<br />

this service is available at short notice and<br />

may be completed within 24 hours<br />

● for elective sperm freezing; from<br />

consultation to sperm freeze, about two to<br />

three weeks<br />

28 | <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> : Preservation <strong>Services</strong>


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

Vasectomy Reversal Back-Up<br />

The MFS Vasectomy Reversal Back-up Plan<br />

(VRBP) enables any man considering a<br />

vasectomy reversal to freeze sperm or<br />

testicular tissue removed during the surgical<br />

procedure, to:<br />

● avoid the need for a second surgical<br />

procedure should the reversal fail and<br />

reduce the cost of any future fertility<br />

treatment<br />

● reduce anxiety, because if the reversal is<br />

unsuccessful, or if the man has continuing<br />

fertility problems, sperm is stored ready<br />

for use with ICSI (see pages 18-19)<br />

Who may benefit?<br />

Any man planning a vasectomy reversal<br />

operation.<br />

What does the procedure involve?<br />

● an MFS scientist attends the vasectomy<br />

reversal operation and collects any<br />

extracted sperm or biopsied testicular<br />

tissue to freeze for use in future possible<br />

ICSI treatment (see pages 18-19)<br />

● after the operation, MFS undertakes a<br />

detailed analysis of the quality of the<br />

sperm being ejaculated following the<br />

reversal, to assess any need to freeze<br />

sperm in case the reversal is not<br />

permanent<br />

● if no sperm can be produced naturally<br />

following the reversal, the sample<br />

collected during the reversal procedure<br />

may be used in ICSI treatment<br />

What is included in the cost?<br />

● infection screen and pre-conception<br />

consultation<br />

● extraction and freezing of sperm<br />

● one year's storage of sperm<br />

● post-reversal semen analysis and freezing<br />

of ejaculated sperm (if appropriate)<br />

● the vasectomy reversal procedure and<br />

ICSI treatment are not included in the cost<br />

of the VRBP<br />

How long does treatment take?<br />

The VRBP is scheduled around the vasectomy<br />

reversal operation. MFS can do a sperm<br />

analysis two to four weeks after the reversal<br />

surgery and sperm can also be frozen at this<br />

time, in case any initial success is not<br />

permanent.<br />

Results<br />

MFS is confident that the VRBP should be<br />

successful for a previously fertile man. (See<br />

page 21 for the results of ICSI using surgically<br />

recovered sperm.)<br />

Preservation <strong>Services</strong> : <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> | 29


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

Egg Freezing<br />

Freezing eggs is a much newer technique than<br />

sperm or embryo freezing and has been<br />

available at MFS since 2000. To date (August<br />

2009), MFS continues to be the only UK clinic<br />

to have achieved livebirths following the<br />

freezing of the mothers' own eggs, after the<br />

birth of four babies since June 2002. These<br />

livebirths were achieved using a 'slow-freeze'<br />

method, but since late 2008 MFS has also<br />

been able to vitrify eggs, a process which may<br />

improve pregnancy rates by increasing the<br />

survival rates of the eggs after thawing from<br />

65% to 95%.<br />

Egg freezing offers no guarantee of successful<br />

future conception. The chance of a woman<br />

achieving a successful pregnancy is higher<br />

when she conceives before the age of 35.<br />

Who may benefit?<br />

'emergency' egg freezers:<br />

● young women with cancer who require<br />

chemotherapy or radiotherapy which may<br />

harm their ovaries and damage their<br />

fertility<br />

● other women who need to freeze eggs<br />

within one month because of an<br />

emergency medical condition<br />

'elective' egg freezers, including:<br />

● women who are not in a relationship and<br />

who want to 'preserve' their fertility<br />

● women with non-emergency medical<br />

conditions which are likely to result in<br />

premature ovarian failure or the loss of<br />

their ovaries<br />

● women who, possibly with their partner,<br />

have ethical concerns about freezing<br />

embryos as part of their fertility treatment<br />

MFS offers two egg freezing services:<br />

● a rapid-response service for 'medical<br />

emergency' patients, available seven days<br />

a week to maximise access to the service<br />

and minimise any delay to the start of<br />

required therapy or surgery<br />

● a comprehensive three-stage service for<br />

all other 'elective egg freezers' to address<br />

the emotional issues often involved in<br />

elective egg freezing which ensures the<br />

client is aware of both the potential and<br />

limitations of egg freezing<br />

What does treatment involve?<br />

For emergency egg freezing patients:<br />

● treatment can be arranged at short notice<br />

● the first part of the process, including egg<br />

collection, is the same as for IVF (see<br />

pages 16 - 17)<br />

For elective egg freezing clients:<br />

● stage one: an ORT (see page 11) to<br />

assess the woman's potential response to<br />

fertility drugs<br />

30 | <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> : Preservation <strong>Services</strong>


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

● stage two: the elective egg freezing<br />

preparation service. If the clinical team is<br />

satisfied that the woman meets the clinical<br />

and scientific criteria and she has met with<br />

the counsellor to consider her ability to<br />

deal with the emotional implications of<br />

elective egg freezing, she may progress to<br />

egg freezing treatment<br />

● stage three: egg freezing. The first part of<br />

the treatment, including egg collection, is<br />

the same as for IVF (see pages 16 - 17)<br />

For all egg freezing patients:<br />

● following egg collection, the eggs are<br />

prepared for freezing using either the<br />

slow-freeze or vitrification processes, or a<br />

combination of both<br />

● the eggs are stored at -196°C. When the<br />

woman is ready to conceive, MFS can<br />

thaw the eggs, fertilise them using ICSI<br />

with partner or donor sperm and transfer<br />

any resulting embryos<br />

What is included in the cost?<br />

For all egg freezers:<br />

● the egg freezing service includes<br />

treatment planning, monitoring scans,<br />

teaching how to give injections, egg<br />

collection and freezing for one year<br />

The subsequent thaw, ICSI fertilisation of the<br />

eggs and the storage fees after the first year<br />

are not included in the cost of the egg freezing<br />

procedure.<br />

For emergency egg freezing patients:<br />

● MFS may be able to secure funding from<br />

the patient's PCT to meet the cost of egg<br />

freezing for cancer patients. The patient is<br />

liable for the cost of the treatment and will<br />

be refunded if funding is secured<br />

For elective egg freezing clients:<br />

● the three stages of treatment are costed<br />

and invoiced separately<br />

● the stage two preparation service includes<br />

two consultations and at least one<br />

counselling appointment<br />

How long does treatment take?<br />

Depending on the drug protocol:<br />

● for emergency egg freezing patients: two<br />

to four weeks from the beginning of the<br />

treatment cycle to egg freezing<br />

● for elective egg freezing clients: around<br />

four months from the beginning of the<br />

elective egg freezing preparation service<br />

to completion of any possible egg freezing<br />

treatment cycle<br />

Results<br />

Worldwide, clinics which fertilise many thawed frozen eggs achieve the same pregnancy rate per<br />

embryo transfer as they achieve for frozen embryo transfers.<br />

Egg Thaws and Transfers: January 2000 - December 2007<br />

Age<br />

All<br />

Total cycles 19<br />

Livebirth rate per cycle started (%) 15.8<br />

Livebirth rate per embryo transfer (%) 18.8<br />

Preservation <strong>Services</strong> : <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> | 31


The <strong>Patients</strong>’ Guide to <strong>Services</strong> 2009-2010<br />

Additional <strong>Services</strong><br />

MFS always seeks to enhance its range of services and now offers both acupuncture therapy and<br />

ante-natal scanning at the unit for the benefit of MFS patients, before, during and after<br />

conception.<br />

Acupuncture<br />

Acupuncture is at the forefront of the rapid<br />

growth of complementary therapies in the UK.<br />

As practiced by members of the British<br />

Acupuncture Council (BAcC), it is an holistic<br />

approach to health based on more than 2,000<br />

years of development and refinement in the<br />

Far East. The tradition is as much about the<br />

maintenance of general health and well-being<br />

as the management of a particular condition<br />

and a number of studies have suggested that<br />

acupuncture around the time of embryo<br />

transfer may improve success rates in IVF<br />

cycles. In addition it may be useful in managing<br />

stress associated with sub-fertility and fertility<br />

treatment.<br />

The acupuncture service at MFS is provided by<br />

June Powell, a member of BAcC, and is<br />

available on Thursdays at MFS and by<br />

arrangement at another time or venue. To<br />

make an appointment contact her on 07860<br />

168254 or 01295 738644.<br />

MUMS@MFS Ante-natal <strong>Services</strong><br />

MFS now offers a range of ante-natal<br />

screening services via a satellite service from<br />

MUMS - <strong>Midland</strong>s Ultrasound Medical<br />

<strong>Services</strong> (visit www.mums.me.uk).<br />

MUMS offers the very latest in nuchal and<br />

marker scanning for Down's and other<br />

Still and moving 4D scans by MUMS provide clear<br />

images in the uterus of a baby's development and<br />

features<br />

chromosomal conditions, plus 20 week<br />

anomaly and 26 week fetal well-being scans.<br />

In addition, parents-to-be enjoy the<br />

reassurance of the latest-technology, noninvasive<br />

4D diagnostic and screening<br />

scans,which give much clearer still and DVD<br />

images of the baby at 26-28 weeks than<br />

regular ultrasound scanning. All these<br />

services are available at MUMS in Solihull, but<br />

MUMS@MFS brings them to MFS patients on<br />

Thursday afternoons in the familiar<br />

environment of the MFS unit.<br />

To make an appointment for ante-natal<br />

scanning with MUMS@MFS, contact MUMS<br />

on 0121 704 2669.<br />

32 | <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> : Additional <strong>Services</strong>


<strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> is an independent hospital,<br />

established in 1987 for the investigation and<br />

treatment of infertility. MFS specialises in<br />

assisted conception techniques and<br />

employs highly-qualified, full-time<br />

staff dedicated to their work at MFS.<br />

Statutory Compliance<br />

MFS is licensed by the Human Fertilisation and Embryology<br />

Authority, centre no 008, for the performance of IVF, ICSI,<br />

gamete and embryo donation and for gamete and<br />

embryo storage:<br />

Nominal licensee: Anna Kavanagh<br />

Person responsible: Gillian Lockwood<br />

Accredited consultant: Mike Bowen<br />

MFS is registered with the Care Quality Commission<br />

as an independent hospital providing in vitro<br />

fertilisation, certificate number P030002061.<br />

Registered provider: <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> Ltd<br />

Registered manager: Anna Kavanagh<br />

Responsible individual: Heidi Birch<br />

For a copy of the most recent MFS inspection report<br />

visit www.cqc.org.uk and search for <strong>Midland</strong> <strong>Fertility</strong><br />

<strong>Services</strong> in the section ‘Find Care <strong>Services</strong>’,<br />

or telephone 03000 616161.<br />

MFS:<br />

●<br />

●<br />

●<br />

●<br />

is certified by BSI Quality Assurance with<br />

BS EN 9001:2008 (formerly BS5750)<br />

is registered with the Office of Data Protection<br />

Registrar and adheres to its code of practice<br />

delivers counselling support within the ethical<br />

framework of the British Association for<br />

Counselling and Psychotherapy<br />

has Investor in People accreditation<br />

© 2009 <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> Ltd<br />

All rights reserved. No paragraph or other parts of this publication may be reproduced or transmitted in any form or by<br />

any means, including photocopying and recording, without the written permission of <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> Ltd.


<strong>Services</strong> at MFS<br />

●<br />

●<br />

●<br />

●<br />

●<br />

●<br />

●<br />

●<br />

●<br />

<strong>Fertility</strong> Investigation Package<br />

Ovarian Reserve Testing<br />

Recurrent Miscarriage Monitoring<br />

Sperm Analysis<br />

Intrauterine Insemination (IUI)<br />

In Vitro Fertilisation (IVF)<br />

Intra Cytoplasmic Sperm Injection (ICSI)<br />

Surgical Sperm Retrieval<br />

Egg Sharing<br />

●<br />

●<br />

●<br />

●<br />

●<br />

●<br />

●<br />

●<br />

●<br />

Egg/Embryo Donation<br />

Surrogacy<br />

Sperm Freezing<br />

Vasectomy Reversal Back-Up Plan<br />

Egg Freezing (including Vitrification)<br />

Embryo Freezing<br />

Blastocyst Culture and Transfer<br />

Assisted Hatching<br />

Genetic Screening<br />

How to get to <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong><br />

Third Floor, Centre House,<br />

Court Parade, Aldridge,<br />

West <strong>Midland</strong>s WS9 8LT<br />

t: 01922 455911<br />

f: 01922 459020<br />

e: mfs@midlandfertility.com<br />

w: www.midlandfertility.com<br />

Issue: 01-10/2009<br />

© 2009 <strong>Midland</strong> <strong>Fertility</strong> <strong>Services</strong> Ltd

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