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An Introduction to Recursive Partitioning Using the RPART Routines ...

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grade11.845<br />

g262.5<br />

Prog<br />

Prog<br />

Figure 6: Classication tree for <strong>the</strong> Stage C data<br />

6 Examples with explanation of output<br />

6.1 Stage C prostate cancer (class method)<br />

This rst example is based on a data set of 146 stage C prostate cancer patients<br />

[4]. The main clinical endpoint ofinterest is whe<strong>the</strong>r <strong>the</strong> disease recurs after initial<br />

surgical removal of <strong>the</strong> prostate, and <strong>the</strong> time interval <strong>to</strong> that progression (if any).<br />

The endpoint in this example is status, which takes on <strong>the</strong> value 1 if <strong>the</strong> disease<br />

has progressed and 0 if not. Later we'll analyze <strong>the</strong> data using <strong>the</strong> exp method,<br />

which will take in<strong>to</strong> account time <strong>to</strong> progression. A short description of each of <strong>the</strong><br />

variables is listed below. The main predic<strong>to</strong>r variable of interest in this study was<br />

DNA ploidy, as determined by ow cy<strong>to</strong>metry. For diploid and tetraploid tumors,<br />

<strong>the</strong> ow cy<strong>to</strong>metric method was also able <strong>to</strong> estimate <strong>the</strong> percent of tumor cells<br />

in a G 2 (growth) stage of <strong>the</strong>ir cell cycle G 2 % is systematically missing for most<br />

aneuploid tumors.<br />

The variables in <strong>the</strong> data set are<br />

13

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