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FACTS about<br />

Skin Cancer<br />

Skin cancer is the most common type of cancer in the United<br />

States, with more than two million new cases diagnosed each year.<br />

Up to 50 percent of Americans who reach age 65 will have some<br />

type of skin cancer. It’s also increasing in young people.<br />

The skin is made up of three main layers:<br />

the epidermis (outer layer); the dermis<br />

(middle layer); and the subcutis (the deepest<br />

layer). The epidermis has three different<br />

types of cells: squamous cells form the top<br />

level; basal cells form the next layer; and<br />

the deepest layer contains melanocytes,<br />

cells that give skin its color. Skin cancers<br />

are caused when DNA of cells are damaged<br />

and the cells grow uncontrollably to form<br />

a tumor.<br />

There are three major types of skin<br />

cancer. The names of the three types come<br />

from the type of skin cell in which they<br />

begin: basal cell carcinoma; squamous cell<br />

carcinoma; and melanoma. (Carcinoma is<br />

the name given to cancers that begin in<br />

cells that cover or line an organ.) Other<br />

skin cancers combined make up less than 1<br />

percent of cases. These include Merkel cell<br />

carcinoma, adnexal tumors, various types of<br />

sarcomas, and cutaneous lymphomas.<br />

Basal cell carcinoma<br />

(BCC)<br />

This is the most common cancer, accounting<br />

for about 80 percent of diagnosed<br />

cases. Most BCCs are on skin that has<br />

extensive exposure to the sun, such as face,<br />

ears, scalp, and upper chest and back. These<br />

are slow-growing cancers that rarely spread<br />

(metastasize). Early diagnosis and treatment<br />

can prevent damage to areas around the<br />

cancer and metastasis. Usually, BCCs look<br />

like small, smooth, pearly or waxy bumps.<br />

Squamous cell carcinoma<br />

(SCC)<br />

This is the second most common type,<br />

accounting for about 20 percent of cases.<br />

SCCs often come from spots that are dry,<br />

scaly, reddish-brown, yellowish-black, or<br />

normal skin color and are called actinic<br />

keratoses. Most SCCs are on areas of the<br />

skin that have had exposure to the sun, but<br />

they can be found on other areas, such as<br />

the mouth and genital area. The majority<br />

occur in fair-skinned and elderly people.<br />

SCCs can metastasize if not treated. Usually<br />

squamous cell cancers look like firm, red<br />

bumps, or rough, scaly flat areas that may<br />

itch, bleed, and form a crust.<br />

Basal cell and squamous<br />

cell carcinomas can cause<br />

considerable damage and<br />

disfigurement if untreated.<br />

If detected and treated early,<br />

however, these carcinomas<br />

have a cure rate of more<br />

than 95 percent.<br />

Melanoma<br />

This form of skin cancer<br />

is least common, causing<br />

less than 5 percent of skin<br />

cancer cases. It begins in the<br />

melanocytes, the cells in the<br />

skin that give skin its color.<br />

This type of cancer usually<br />

develops in a mole or a spot<br />

that looks like a mole.<br />

Malignant melanoma causes a large majority<br />

of all deaths from skin cancer. This<br />

disease can spread to the lymph system and<br />

other organs, most commonly the lungs,<br />

liver, and brain. Malignant melanoma diagnosed<br />

at an early stage usually can be cured,<br />

but melanoma diagnosed at a late stage is<br />

more likely to have spread and cause death.<br />

Causes<br />

Exposure to the sun’s ultraviolet (UV)<br />

rays appears to be the most important<br />

environmental factor in the development<br />

of all three types of skin cancer. The sun’s<br />

ultraviolet rays (UV) damage the DNA of<br />

skin cells.<br />

<strong>Summit</strong> Active 2

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