Annual Meeting Program - Society of Toxicology

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SETTING THE PACE FOR SCIENCE Program Description (Continued) Abstract numbers are followed by the bolded abstract presentation time or the poster board number. #1547 422 PHYSICOCHEMICAL AND CELL- BASED APPROACH FOR PREDICTING OF PHOSPHOLIPIDOSIS-INDUCING POTENTIAL IN EARLY DRUG DISCOVERY. K. Tomizawa 1 , K. Sugano 2 , H. Yamada 1 and I. Horii 1 . 1 Drug Safety Research & Development, PGRD Nagoya Laboratories, Pfizer Inc., Aichi, Japan and 2 Pharmaceutical R&D, PGRD Nagoya Laboratories, Pfizer Inc., Aichi, Japan. Sponsor: M. Kurata. #1548 423 ACETALDEHYDE INHALATION TOXICITY APPERARS SEVER IN ALDEHYDE DEHYDROGENASE 2 KNOCKOUT MICE; : 0, 125 AND 500 PPM 24HR 2WEEKS STUDY. T. Isse 1 , T. Oyama 1 , K. Matsuno 2 , M. Muto 3 , I. Uchiyama 4 and T. Kawamoto 1 . 1 Environmental Health, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan, 2 Bio-information Research Center, University of Occupational and Environmental Health, Kitakyushu, Japan, 3 Endoscopy and Gastrointestinal Oncology Division, National Cancer Center Hospital East, Kashiwa, Japan and 4 Department of Environmental Hygiene, School of Technology, Kyoto University, Kyoto, Japan. #1549 424 DEVELOPMENT OF TEFS FOR PCB CONGENERS BY USING AN ALTERNATE ENDPOINT—THYROID HORMONE. J. Yang, A. G. Salmon and M. A. Marty. OEHHA, Cal/EPA, Oakland, CA. #1550 425 MECHANISM-BASED CANCER RISK ASSESSMENT FOR 1, 4- DICHLOROBENZENE. B. E. Butterworth 1 , L. Aylward 2 and S. M. Hays 3 . 1 Butterworth Consulting, Raleigh, NC, 2 Summit Toxicology, LLP, Falls Church, VA and 3 Summit Toxicology, LLP, Lyons, CO. #1551 426 RISK ASSESSMENT FOR SITES WITH VOLATILE CONTAMINANTS IN SHALLOW GROUNDWATER. P. Wong-Yim, T. L. Taras, B. K. Davis and M. J. Wade. Toxic Substances Control, California Environmental Protection Agency, Sacramento, CA. #1552 427 DERIVATION OF A DRINKING WATER ACTION LEVEL FOR TRIS(MONOCHLOROPROPYL) PHOSPHATE ISOMERS. J. Shoenfelt 1 , M. H. Whittaker 1 , A. Gebhart 2 and F. Hammer 2 . 1 ToxServices LLC, Washington, DC and 2 Underwriters Laboratories, Inc., Northbrook, IL. #1553 428 TESTING FOR ADDITIVITY IN THE LOW DOSE REGION OF AN ENVIRONMENTALLY RELEVANT MIXTURE OF 18 POLYHALOGENATED AROMATIC HYDROCARBONS. C. Gennings 1, 2 , L. Stork 3 , M. DeVito 4 , B. Reeves 5 and K. Crofton 4 . 1 Biostatistics, VCU, Richmond, VA, 2 Solveritas, LLC, Richmond, VA, 3 Monsanto Co., St. Louis, MO, 4 NHEERL, U.S. EPA, Research Triangle Park, NC and 5 Tetra Tech, Inc., Collinsville, IL. #1554 429 HEALTH RISK ASSESSMENT OF METHYL ISOBUTYL KETONE IN DRINKING WATER. J. De France, V. S. Bhat, G. L. Ball and C. J. McLellan. NSF International, Ann Arbor, MI. #1555 430 SUPPORT FOR SELECTION OF A METHAMPHETAMINE CLEANUP STANDARD IN COLORADO. T. L. Hammon 1 and S. Griffin 2 . 1 Colorado Department of Public Health & Environment, Denver, CO and 2 U.S. EPA Region 8, Denver, CO. #1556 431 HEALTH RISK ASSESSMENT OF 4- CHLOROBENZOTRIFLOURIDE IN DRINKING WATER. C. J. Lee, V. S. Bhat, G. L. Ball and C. J. McLellan. NSF International, Ann Arbor, MI. #1557 432 AN EVALUATION OF THE MODE OF ACTION INFORMATION FOR HEXACHLOROETHANE USING U.S. EPA’S 2005 GUIDELINES FOR CARCINOGEN RISK ASSESSMENT. S. Jones 1 and J. Kim 2 . 1 U.S. EPA, Washington, DC and 2 Sciences International, Inc., Alexandria, VA. #1558 433 MUCOSAL IRRITATION OF VAPORS OF HEXANAL, ACETIC ACID AND DIOXANE IN HUMANS. L. Ernstgård 1 , A. Iregren 2 , B. Sjögren 1 and G. Johanson 1 . 1 Work Environment Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden and 2 National Institute for Working Life, Stockholm, Sweden. #1559 434 NASAL IRRITATION AND TUMORS IN RATS EXPOSED TO CHEMICALS IN DRINKING WATER MAY RESULT FROM DIRECT CONTACT WITH NASAL TISSUES. J. K. Thomas 1 , T. J. Weber 1 , D. L. Stenoien 1 , A. D. Woodstock 1 , K. R. Minard 1 , B. J. Locey 2 , R. Clarkson 2 , S. Sager 2 and R. A. Corley 1 . 1 Pacific Northwest National Laboratory, Richland, WA and 2 Arcadis G&M of Michigan, Southfield, MI. #1560 435 DEVELOPMENT OF WEIGHTED DISTRIBUTIONS OF REPS FOR DIOXIN- LIKE COMPOUNDS (DLCS). L. Haws 1 , N. Walker 2 , M. DeVito 3 , L. Birnbaum 3 , K. Unice 4 , P. Scott 4 , M. Harris 5 , W. Farland 3 , B. Finley 6 and D. Staskal 1 . 1 ChemRisk, Austin, TX, 2 NIEHS, Research Triangle Park, NC, 3 U.S. EPA, Research Triangle Park, NC, 4 ChemRisk, Pittsburgh, PA, 5 ChemRisk, Houston, TX and 6 ChemRisk, San Francisco, CA. #1561 436 CANCER POTENCY ESTIMATE FOR 2, 3, 4, 7, 8-PENTACHLORODIOBENZO(P)DIOXIN (4-PECDF). C. Kirman 1 , E. Crouch 2 , L. Aylward 3 , T. Simon 4 , R. Budinsky 5 , B. Landenberger 5 and T. Long 1 . 1 The Sapphire Group, Beachwood, OH, 2 Cambridge Environmental Inc., Cambridge, MA, 3 Summit Toxicology, Falls Church, VA, 4 Simon Creative, Atlanta, GA and 5 The Dow Chemical Co., Midland, MI. WEDNESDAY up-to-date information at www.toxicology.org 207
46 th Annual Meeting & ToxExpo TM Program Description (Continued) Abstract numbers are followed by the bolded abstract presentation time or the poster board number. WEDNESDAY #1562 437 DIVERGENT TRANSCRIPTIONAL PROFILES INDUCED BY THE AHR AGONISTS 2, 3, 7, 8-TCDD, 2, 3, 7, 8-TCDF AND 2, 3, 4, 7, 8-PECDF IN PRIMARY RAT HEPATOCYTES. B. Gollapudi 1 , R. Budinsky 1 , A. Dombkowski 2 , R. Novak 2 , M. Abdelmegeed 2 , T. Zacharewski 3 , L. Burgoon 3 and C. Rowlands 1 . 1 The Dow Chemical Company, Midland, MI, 2 Wayne State University, Detroit, MI and 3 Toxicogenomic Informatics and Solutions, LLC, East Lansing, MI. #1563 438 TOWARDS AN INTEGRATED PHOTO SAFETY ASSESSMENT DURING DRUG DEVELOPMENT: EVALUATION OF MECHANISM-RELATED TEST APPROACHES BROADENING THE REGULATORY TEST BATTERY. D. M. Bauer, M. Struwe, M. Trunzer, A. Mueller, U. Plappert-Helbig, P. Ulrich, H. Martus and W. Suter. Exploratory Development, Novartis Pharma AG, Basel, Switzerland. #1564 439 PERFLUORO-N-BUTYL IODIDE (PFBI): OCCUPATIONAL HEALTH HAZARD EVALUATION. D. E. Dodd 1 , G. M. Hoffman 2 and D. R. Mattie 3 . 1 CIIT Centers for Health Research, Research Triangle Park, NC, 2 Huntingdon Life Sciences, East Millstone, NJ and 3 AFRL/HEPB, Wright-Patterson AFB, OH. #1565 440 A RETROSPECTIVE ANALYSIS OF 12 HUMAN STUDIES WITH PESTICIDES (1992 TO 2001) TO ASSESS RBC ACHE ACTIVITY AND CLINICAL SIGNS. J. Doherty, E. Reaves, L. Taylor and L. Scarano. U.S. EPA, Washington, DC. #1566 441 ACUTE EXPOSURE GUIDELINE LEVELS (AEGLS) FOR CROTONALDEHYDE. S. Milanez. Oak Ridge National Laboratory, Oak Ridge, TN. #1567 442 RISK ASSESSMENT FOR EXPOSURES TO PCBs FROM INTERIOR BUILDING SURFACES. T. A. Lewandowski. Gradient Corporation, Seattle, WA. #1568 443 CANDIDATE BENCHMARK BLOOD-LEAD AND BONE-LEAD CONCENTRATIONS. N. Healey 1 and A. Knafla 2 . 1 Health Canada, Sidney, BC, Canada and 2 Equilibrium Environmental Inc., Calgary, AB, Canada. Sponsor: S. Safe. #1569 444 CARCINOGENICITY EVALUATION OF METHYL TERT-BUTYL ETHER (MTBE). L. A. Beyer, J. Goodman, M. Seeley, T. Slayton and B. Beck. Gradient Corp., Cambridge, MA. Wednesday Morning, March 28 9:00 AM to 12:30 PM Exhibit Hall POSTER SESSION: SIGNALLING AND GENE REGULATION Chairperson(s): Serrine Lau, University of Arizona, Tucson, AZ and Martin Ronis, University of Arkansas Medical Sciences, Little Rock, AR. Displayed: 9:00 AM–12:30 PM Attended: 10:45 AM–12:30 PM #1570 447 NOVEL PROTEOMIC APPROACH TO MAPPING SIGNALING PATHWAYS INDUCED BY SPECIFIC ISOMERS OF METHYLATED ANTHRACENES. B. L. Upham 1, 2 , D. A. Whitten 3 , C. G. Wilkerson 3 , J. E. Trosko 1, 2 and L. Blaha 1, 2 . 1 Pediatrics and Human Development, Michigan State University, East Lansing, MI, 2 National Food Safety & Toxicology Center, Michigan State University, East Lansing, MI and 3 RTSF Proteomic Core, Michigan State University, East Lansing, MI. #1571 448 INVOLVEMENT OF I-KAPPA B KINASE IN ANILINE-INDUCED ACTIVATION OF TRANSCRIPTION FACTOR NF-KAPPA B IN RAT SPLEEN. J. Wang, G. Wang and M. Khan. Pathology, University of Texas Medical Branch, Galveston, TX. #1572 449 THIOREDOXIN REDUCTASE IS REQUIRED FOR MAXIMAL NF-κB-MEDIATED GENE EXPRESSION. J. Heilman and W. H. Watson. Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. #1573 450 SUPPRESSION OF TNF-α-INDUCED EXPRESSION OF CELL ADHESION MOLECULES BY THE COFFEE DITERPENE KAHWEOL VIA INHIBITION OF JAK2-PI3K/ AKT-NF-κB ACTIVATION PATHWAY. H. Kim 1, 2 , Y. Hwang 1, 2 , D. Kim 3 and H. Jeong 1, 2 . 1 Pharmacy, Chosun University, Kwangju, South Korea, 2 Research Center for Proteineous Materials, Chosun University, Kwangju, South Korea and 3 Pathology, College of Oriental Medicine, Daejeon University, Daejeon, South Korea. #1574 451 PPARγ-INDEPENDENT MECHANISMS REGULATING THE ACTIVATION OF SRC KINASE BY THIAZOLIDINEDIONES. B. J. Dewar 1 , J. Samet 1 and L. M. Graves 1, 2 . 1 Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC and 2 Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC. #1575 452 EARLY GROWTH RESPONSE GENE 1 (EGR- 1) MEDIATES DEOXYNIVALENOL-INDUCED INTERLEUKIN-8 PRODUCTION IN HUMAN INTESTINAL EPITHELIAL CELLS. H. Yang 1 , M. Lee 1 and Y. Moon 1, 2 . 1 Microbiology and Immunology, Pusan National University School of Medicine, Pusan, South Korea and 2 Medical Research Institute, PNUSM, Pusan, South Korea. Sponsor: T. Jeong. 208 SOT’s 46 th Annual Meeting
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PROGRAM 46 th Annual 46 Annual Meet
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Scientific Program Overview 7:00 AM
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Society of Toxicology Awards 46 th
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SPONSORSHIP OPPORTUNITIES SPONSORSH
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