Annual Meeting Program - Society of Toxicology

Society of Toxicology 2012
Program Description (Continued)
Abstract #
#1497 Poster Board Number......................................403
NI IN AMBIENT PM CAUSES
MICROVASCULAR DYSFUNCTION VIA NO
AND NADPH PATHWAYS. ​A. K. Cuevas, E.
Liberda, C. Chiu, Q. Qu, and L. Chen. Environmental
Medicine, New York University School of Medicine,
Tuxedo, NY.
#1498 Poster Board Number......................................404
TREADMILL STRESS TEST AFTER DIESEL
EXHAUST PARTICULATE EXPOSURE
REVEALS A TIME-DEPENDENT SHIFT FROM
PARASYMPATHETIC TO SYMPATHETIC
DOMINANCE. ​A. P. Carll 1 , C. M. Perez 2 , A. K.
Farraj 3 , and D. L. Costa 4 . 1 School of Public Health,
University of North Carolina at Chapel Hill, Chapel
Hill, NC, 2 CURTOX, University of North Carolina at
Chapel Hill, Chapel Hill, NC, 3 Environmental Public
Health Division, US EPA, Research Triangle Park,
NC, and 4 ORD, US EPA, Research Triangle Park, NC.
#1499 Poster Board Number......................................405
CHRONIC EXPOSURE TO DIESEL EXHAUST
PARTICULATE INDUCES VENTRICULAR
REMODELING AND DYSFUNCTION. ​J.
Bradley, and J. D. Gardner. Louisiana State University
Health Science Center, New Orleans, LA. Sponsor:
T. Dugass.
#1500 Poster Board Number......................................406
DOSE-DEPENDENT INCREASES FOR
THORACIC AORTA PLAQUE DEVELOPMENT
IN APOE-/- MICE WITH CIGARETTE SMOKE
INHALATION EXPOSURE. ​G. M. Curtin 1 , J. E.
Swauger 1 , and K. J. Nikula 2 . 1 Regulatory Oversight,
R.J. Reynolds Tobacco Company, Winston Salem,
NC, and 2 Seventh Wave Laboratories, Chesterfield,
MO.
#1501 Poster Board Number......................................407
AMBIENT MOUNTAIN TOP MINING
PARTICULATE MATTER ALTERS SYSTEMIC
MICROVASCULAR FUNCTION. ​T. L. Knuckles 1 ,
P. Stapleton 1 , V. Minarchick 1 , M. McCawley 2 , L.
Esch 2 , M. Hendryx 2 , and T. Nurkiewicz 1 . 1 Center
for Cardiovascular and Respiratory Sciences,
West Virginia University, Morgantown, WV, and
2
Department of Community Medicine, West Virginia
University, Morgantown, WV.
#1502 Poster Board Number......................................408
SUBCHRONIC EFFECTS OF
CONCENTRATED AMBIENT PARTICLES ON
HEMODYNAMIC CHANGE AND ORGAN
DAMAGE IN ISOPROTERENOL-INDUCED
MYOCARDIAL INJURY RATS. ​T. Cheng 1 , Y.
Yan 1,2 , C. Huang 3 , J. Wang 4 , C. Tung 5 , P. Chen 1 , and
L. Chen 6 . 1 Institute of Occupational Medicine and
Industrial Hygiene, National Taiwan University,
Taipei, Taiwan, 2 Department of Medical Research,
Chia-Yi Christian Hospital, Chiayi, Taiwan,
3
Department of Emergency Medicine, National
Taiwan University Medical College and Hospital,
Taipei, Taiwan, 4 Department of Pathology, Kaohsiung
Veterans General Hospital, Kaohsiung, Taiwan,
5
Department of Pathology, Chia-Yi Christian
Hospital, Chiayi, Taiwan, and 6 Department of
Environmental Medicine, New York University
School of Medicine, New York, NY.
Abstract #
#1503 Poster Board Number......................................409
PULMONARY EXPOSURE TO PARTICULATE
MATTER LEADS TO OXIDANT STRESS
IN EXTRAPULMONARY ARTERIOLES OF
FEMALE RATS. ​M. Boegehold, and T. Nurkiewicz.
Center for Cardiovascular and Respiratory Sciences,
West Virginia University, Morgantown, WV.
#1504 Poster Board Number......................................410
CARDIOMYOCYTE AUTOPHAGY IN
SPRAGUE DAWLEY RATS TREATED WITH
IMATINIB, A TYROSINE KINASE INHIBITOR,
ASSESSED BY IMMUNOHISTOCHEMISTRY. ​
J. Zhang, A. Knapton, K. Shea, and E. H. Herman.
Division of Drug Safety Research, US FDA, Silver
Spring, MD.
#1505 Poster Board Number......................................411
CARDIOTOXICITY IN MALE SPRAGUE
DAWLEY RATS TREATED DAILY FOR UP
TO 4 WEEKS WITH IMATINIB. ​E. Herman 1 ,
A. Knapton 1 , E. Rosen 1 , J. Todd 2 , A. Lu 2 , J. Estis 2 , S.
Lipshultz 3 , and J. Zhang 1 . 1 US FDA, Silver Spring,
MD, 2 Singulex, Inc., Alameda, CA, and 3 University of
Miami, Miller School of Medicine, Miami, FL.
#1506 Poster Board Number......................................412
MECHANISTIC INVESTIGATION OF
IMATINIB-INDUCED CARDIAC TOXICITY
AND THE INVOLVEMENT OF C-ABL KINASE. ​
W. Hu 1 , S. Lu 1 , I. McAlpine 2 , D. Lee 1 , J. Jamieson 1 , L.
Marroquin 1 , J. Heyen 1 , D. Ramirez 1 , S. Jenkinson 1 ,
and B. Jessen 1 . 1 Drug Safety R&D, Pfizer, San Diego,
CA, and 2 Medicinal Chemistry, Pfizer, San Diego, CA.
#1507 Poster Board Number......................................413
CHRONIC DOXORUBICIN
CARDIOTOXICITY MODULATES
EXPRESSION OF CYTOCHROME P450
AND SOLUBLE EPOXIDE HYDROXYLASE
ACTIVITY IN RATS. ​A. M. Alsaad, B. N. Zordoky,
and A. O. El-Kadi. Pharmacy and Pharmaceutical
Sciences, University of Alberta, Edmonton, AB,
Canada.
#1508 Poster Board Number......................................414
COMPARISONS OF CARDIAC TROPONIN
BIOMARKER ASSAYS AFTER A SINGLE
ISOPROTERENOL DOSE IN MALE HAN
WISTAR RATS. ​P. I. Bentley 1 , C. Betts 2 , G.
Budd 2 , J. Fikes 1 , and D. Brott 3 . 1 Safety Assessment,
AstraZeneca, Waltham, MA, 2 Safety Assessment,
AstraZeneca, Alderly Park, United Kingdom, and
3
Clinical Patient Safety Sciences, AstraZeneca,
Wilmington, DE.
#1509 Poster Board Number......................................415
CHRONIC PROBUCOL TREATMENT
DECREASES THE SLOW COMPONENT OF
THE DELAYED-RECTIFIER POTASSIUM
CURRENT IN CHO CELLS TRANSFECTED
WITH KCNQ1 AND KCNE1: A NOVEL
MECHANISM OF QT PROLONGATION. ​T.
Taniguchi, M. Uesugi, T. Arai, T. Yoshinaga, N.
Miyamoto, and K. Sawada. Eisai Co., Ltd., Tsukubashi,
Japan. Sponsor: A. Suganuma.
Tuesday
Poster Sessions
Regional Interest Session
Roundtable Sessions
Symposium Sessions
Thematic Sessions
Workshop Sessions
259