Andrea Imperatori, MD - The University of Insubria

Andrea Imperatori, MD
Contact data
Biography
Assistant Professor
Department of Surgical Sciences
Thoracic Surgery, Ospedale di Circolo, Viale Borri, 57 – 21100 Varese
(Italy)
Tel:: +39-0332-278868
Fax: +39-0332-264169
E-mail: andrea.imperatori@uninsubria.it
Dr. Imperatori qualified as Medical Doctor at the University of Pavia
School of Medicine in 1994. After spending part of his professional
training at the European Institute of Oncology, Milano (September
1995-May 1996), in the year 2000 he completed his graduate work in
General Surgery at the University of Insubria, Varese.
Dr. Imperatori's specific clinical interests include surgical infections,
detection and treatment of early lung cancer, general thoracic surgery,
pleural mesothelioma and minimally invasive surgery such as videoassisted
thoracic surgery (VATS).
Dr. Imperatori has been actively involved in the development of several
research projects. These include: treatment with high-dose
immunoglobulins in severely septic patients; early postoperative
internal nutrition in gastrointestinal cancer patients; a lung cancer
screening program in the Province of Varese, Italy, named Progetto
PRE.DI.CA.; translational research for the identification of target
therapy for lung cancer and pleural mesothelioma.
He cumulatively spent one year at the University Hospitals of Stocktonon-Tees
and Hartlepool, Great Britain, in an Honorary Research Post,
during 2000-2001 carrying out comparative research on lung cancer
epidemiology and treatment in Teesside (UK) and the Province of
Varese (Italy).
He is currently a research fellow in General Surgery at the School of
Medicine at the University of Insubria in Varese, where he teaches
academic courses in three graduate schools (General Surgery,
Thoracic Surgery and Respiratory Diseases), and three specific
Courses for physiotherapists, radiologic technicians, and clinical
laboratorists.
Qualifications and awards
General certificate of education obtained at Liceo Classico "S.M.
Legnani" in Saronno, Italy, 1987
Medical Doctor qualification degree obtained at the University of Pavia,
1994. Thesis: "Therapy of severe surgical infections with high-dose

immunoglobulins.”
Medical licensure: University of Pavia, 1995
Specialized in General Surgery, 2000
Research interests
Surgical Infections:
identification of the high risk surgical patient;
antibiotic prophylaxis and treatment;
high-dose immunoglobulins in severely septic patients.
Surgical Nutrition:
nutrition and infection in surgical patients;
Immediate postoperative enteral nutrition.
Surgical Oncology:
high risk cancer patients;
detection and treatment of early lung cancer;
lung cancer screening;
malignant pleural mesothelioma.
Mininvasive surgery:
advances in video-assisted thoracoscopic surgery;
localization and treatment of small lung nodules.
Translational Research:
applied to lung cancer and to pleural mesothelioma.
Teaching experience and
appointments
Research Fellow, Assistant Professor in Surgery, 2001-present
Member of the Scientific Committee of the Center of Thoracic Surgery,
University of Insubria (2003-2005 and 2005-2008)
Member of the Postgraduate Course of Doctorate in Surgery and
Biotechnologies, University of Insubria (2003-present)
Member of the Council of the Postgraduate School in General Surgery
Member of the Council of the Postgraduate School in Thoracic Surgery
Member of the Council of the Postgraduate School in Respiratory
Diseases
Official Course of General Surgery (for radiologic technician; for clinical
laboratorist)
Official Course of Thoracic Surgery (for physiotherapist)
Representative
publications
1. Gennari R, Dominioni L, Imperatori A, Bianchi V, Maroni P, Dionigi
R. Alterations in lymphocyte subsets as prognosticators of
postoperative infections. Eur J Surg, 161: 493-499, 1994.
2. Dominioni L, Berizzi F, Besozzi MC, Dozio E, Imperatori A, Bianchi
V, Dionigi R. Early postoperative enteral nutrition (IT). Chir Ital, 46: 36-
41, 1994.

3. Dionigi R, Dominioni L, Benevento A, Carcano G, Imperatori A,
Bianchi V. Use of staplers and early postoperative enteral feeding for
pancreatic resections. Atti del IX Congresso dell'Italian Chapter
American College of Surgeons, 93-100, Roma, 1995.
4. Dominioni L, Imperatori A, Gennari R, Dionigi R. High dose
immunoglobulins for prophylaxis in severe sepsis. In "Immunology and
its impact on infections in surgery", R. Engemann ed., Springer-Verlag,
Berlin, 203-207, 1995.
5. Dominioni L, Bianchi V, Imperatori A, Minoia G, Dionigi R. High-dose
intra-venous IgG for treatment of severe surgical infections. Dig Surg
13, 430-434, 1996.
6. Aftab F, Stoldt S, Testori A, Imperatori A, Chinol M, Paganelli G,
Geraghty J. Radioimmunoguided surgery and colorectal cancer. Eur J
Surg Oncol, 22:381-388, 1996.
7. Testori A, Grana C, Zoboli S, De Cicco T, Fiorenza M, Prisco G,
Chinol M, Imperatori A, Trevisan C, Ukpabi E, Geraghty J, Paganelli G.
Immunolymphoscintigraphy and sentinel node biopsy in high risk stage
I melanoma patients. Eur J Surg Oncol, 22:417-418, 1996.
8. Ochetti A, Alberio MG, Frattini V, Imperatori A, Giovanella L,
Dominioni L, Dionigi R. Early postoperative variations of markers
CYFRA 21-1 and CEA in stage I-II non-small cell lung cancer (NSCLC)
undergoing radical resection. J Jpn Surg Soc, 99:401, 1998.
9. Imperatori A, Rovera F, Dominioni L, Berizzi F, Frattini V, Interdonato
PF, Benevento A, Dionigi R. Infections after oesophagectomy: the role
of blood transfusion and other risk factors. Br J Surg, 86:837, 1999.
10. Dominioni L, Imperatori A, Rovera F, Dionigi G. Minimizing risk in
gastrointestinal surgery. Shock 2000;13:176.
11. Dominioni L, Strauss GM, Imperatori A, Rovera F, Dionigi G.
Screening for lung cancer. Chest Surgery Clinics of North America
2000;10:729-36.
12. Dominioni L, Imperatori A, Rovera F, Ochetti A, Torrigiotti G,
Paolucci M. Stage I non-small cell lung cancer (NSCLC): analysis of
survival and implication for screening. Cancer 2000;89(S):2334-44.
13. Dominioni L, Imperatori A, Rovera F, Ochetti A, Paolucci M, Dionigi
G. Lung cancer screening in cigarette smokers in the province of
Varese, Italy. Cancer 2000;89(S):2345-8.
14. Imperatori A, Leitch DN, Lepore G, Rovera F, Dionigi G, Harrison
RN. Lung cancer in Northern Italy and Northern England: a comparison
of two district general hospitals. Am J Resp Crit Care Med,
2001:163:A73.

15. Dionigi R, Rovera F, Dionigi G, Imperatori A, Ferrari A, Dionigi P,
Dominioni L. Risk factors in surgery. J Chemother 2001;13(1):6-11.
16. Imperatori A, Rovera F, Dionigi G, Carcano G, Dominioni L. Finger
palpation for identification of small pulmonary nodules undergoing
video-assisted thoracoscopic (VATS) resection. Cardiovascular
Engineering 2002;7(1):30.
17. Dominioni L, Imperatori A, Rovera F, Dionigi G, Vassallo F. The
role of videothoracoscopy in the early diagnosis of lung cancer. Osp Ital
Chir 2002;8:248-53.
18. Dominioni L, Imperatori A. Trachea (IT). In: R. Dionigi: Chirurgia,
Masson III Ediz., 2002, pp. 892-8.
19. Dominioni L, Dionigi G, Imperatori A, Ochetti A. Lung (IT). In: R.
Dionigi: Chirurgia, Masson III Ediz., 2002, pp. 899-929.
20. Carcano G, Imperatori A, Uccella L, Pelosi L, Dominioni L.
Trasversal thoraco-mediastinal impalament: case report of a survival
patient (IT). Ann Ital Chir 2002, 73(1):271-4.
21. Rovera F, Imperatori A, Militello P, Morri A, Antonini C, Dionigi G,
Dominioni L. Infections in346 consecutive video-assisted thoracoscopic
procedures. Surgical Infections 2003, 4(1):45-51.
22. Rovera F, Imperatori A, Antonini C, Cardani M, Dominioni L.
Pneumonia after lung resection: analysis of risk factors and of surgical
access in 640 cases. Surgical Infections 2003;4.
23. Imperatori A, Paddeu A, Rovera F, Bascialla L, Dominioni L.
Epidemiology of pleural mesothelioma in the Province of Como in the
years 1996-2000. Proceedings of the International Conference Pleural
Mesothelioma, Como 7-8 November 2003, pp 41-48.
24. Dominioni L, Imperatori A, Rovera F, Paolucci M, Paddeu A. The
fairy-tale of overdiagnosis of lung cancer. Proceedings of the
International Conference Lung Cancer Screening and Early Diagnosis,
Como 8 November 2003, pp 20-34.
25. Dominioni L., Rovera F., Pericelli A., Imperatori A. The rationale of
early enteral nutrition. Acta Bio Medica, 2003,74(S2):41-4.
26. Rovera F, Militello P, Antonini C, Imperatori A, Dominioni L.
Postoperative Candida pneumonia after 500 lung resections (IT).
Minerva Chirurgica, 2003, 59(1):45-51.
27. Cesario A, Trombino S, Galetta D, Margaritora S, Murolo C,
Dominioni L, Imperatori A, Festi L, Granone P, Russo P. Non-small cell
lung cancer: from cytotoxic systemic chemotherapy to molecularly
targeted therapy. Curr Med Chem Anti-Cancer Agents, 2004, 4:231-
245.

28. Cesario A, Russo P, Viaggi S, Trombino S, Imperatori A,
Margaritora S, Dominioni L, Festi L, Porziella V, Granone P. Malignant
pleural mesothelioma: time for translational research. The Lancet
Oncology 2004;5: 591.
29. Russo PA, Catassi A, Cesario A, Imperatori A, Rotolo N, Fini M,
Granone P, Dominioni L. Molecular Mechanisms of Hexavalent
Chromium-induced Apoptosis in Human Bronchoalveolar Cells. Am J
Respir Cell Mol Biol. 2005 Sep 15; [Epub ahead of print]
30. Imperatori A, Harrison RN, Leitch DN, Rovera F, Lepore G, Dionigi
G, Sutton P, Dominioni L. Lung cancer in Teesside (UK) and in Varese
(Italy): a comparison of management and survival. Thorax 2005,
accepted, in press online first.
Clinical interests
Surgical infections
identification of high-risk patient; high-dose immunoglobulins treatment
in severely septic patients
Artificial nutrition
parenteral and enteral nutrition of surgical and severely septic patients
Lung cancer:
epidemiology, screening, bronchoscopy, treatment
Mininvasive surgery:
advances in video-assisted thoracoscopic surgery; treatment of small
lung nodules
Malignant pleural mesothelioma
Surgical treatment and multimodal therapy