R.A. Seaton, Gartnavel General Hospital, Glasgow
R.A. Seaton, Gartnavel General Hospital, Glasgow
R.A. Seaton, Gartnavel General Hospital, Glasgow
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Clinical outcomes with OPAT:<br />
International OPAT registry<br />
International OPAT registry (n=11,427)<br />
Outcomes, n (%)<br />
Improved No change Failed Other<br />
US (N=9826) 9089 (92.5) 226 (2.3) 128 (1.3) 392 (3.9)<br />
UK (N=981) 950 (96.8) 9 (0.9) 13 (1.3) 9 (1.0)<br />
Italy (N=620) 590 (95.1) 8 (1.4) 15 (2.4) 7 (1.1)<br />
OPAT in complicated S. aureus<br />
bacteraemia<br />
• 200 US patients complicated S. aureus bacteraemia<br />
• (Vancomycin or semi-synthetic penicillin) +<br />
gentamicin vs daptomycin<br />
• 103 (51.5%) OPAT patients<br />
• Daptomycin: 50 (48.5%)<br />
• Vancomycin: 30 (29.1%)<br />
• SSP: 23 (22.3%)<br />
• Mean inpatient treatment: 10.5 days (1–49)<br />
• Mean outpatient treatment: 14.9 days (1–49)<br />
Esposito S et al. Int J Antimicrob Agents 2004;24:473–478<br />
Rehm S et al. J Antimicrob Chemother 2009;63:1034–1042<br />
OPAT in complicated S. aureus<br />
bacteraemia<br />
OPAT experience in CORE ®<br />
Proportion of patients, %<br />
OPAT vs IPAT patient characteristics and outcomes<br />
P
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