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Liability in Obstetrical and Gynecologic Ultrasound - Cmebyplaza.com

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MTX <strong>and</strong> Anomalies<br />

Am<strong>in</strong>opter<strong>in</strong>/MTX Syndrome<br />

• Dose effect (threshold)<br />

• Tim<strong>in</strong>g<br />

– > 10 mg/week<br />

–2-2.52.5 weeks<br />

• Undifferentiated cells<br />

• All or none effect (SAB)<br />

–4-10 weeks (6-8 weeks)<br />

• Effect on differentiat<strong>in</strong>g cells<br />

Clayton et al. Obstet Gynecol 2006;107:598-604.<br />

604.

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