Production of 18F-Labeled Radiopharmaceuticals
Production of 18F-Labeled Radiopharmaceuticals
Production of 18F-Labeled Radiopharmaceuticals
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[ 18 F]L-6-Fluoro-DOPA (FDOPA)<br />
- Neuronal uptake<br />
18 F<br />
Blood<br />
OH<br />
OH<br />
NH 2<br />
COOH<br />
BBB<br />
Dopaminergic neuron<br />
OH<br />
18 F<br />
OH<br />
NH 2<br />
COOH<br />
18 F<br />
DOPA<br />
decarboxylase NH 2<br />
OH<br />
OH<br />
Data for Some Important<br />
Reactions Producing 18 F<br />
Reaction Target ThresholdMaximal Energy at Calculated<br />
isotope energy cross maximal thick<br />
section cross target yield<br />
section at saturation<br />
(%) (MeV) (mb) (MeV) (GBq/μA)<br />
16<br />
O( 3 He,p) 18 F 99.76 0<br />
plus ~ 400 ~ 8 1.35 (E 3He<br />
= 35 MeV)<br />
16<br />
O( 3 He,n) 18 Ne a 99.76 3.8<br />
16<br />
O(α,pn) 18 F 99.76 23.2 ~ 136 36 1.00 (E α<br />
= 40 MeV)<br />
18<br />
O(p,n) 18 F 0.205 2.5 ~ 700 5 4.07 (E p<br />
= 8 MeV)<br />
8.88 (E p<br />
= 16 MeV)<br />
20<br />
Ne(d,α) 18 F 90.5 0 ~ 230 6 1.89 (E d<br />
= 8 MeV)<br />
2.81 (E d<br />
= 10 MeV)<br />
a 18<br />
Ne Decays to 18 F with a half-life <strong>of</strong> 1.67 s
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