Prof. Dr. Andrea Hartwig Stand - KIT - Abteilung für ...

Prof. Dr. Andrea Hartwig Stand: Februar 2011
Karlsruher Institut für Technologie (KIT)
Abteilung Lebensmittelchemie und Toxikologie
Wissenschaftliche Veröffentlichungen
2011
147. Hartwig, A., (2011) Genotoxicity of fibres in subcellular and cellular test systems:
general aspects, in: Mechanisms of Fibre Carcinogenesis, PART I, IARC
Scientific publications, in press
146. Parlar, H., Hartwig, A. (2011) The MAK-Collection for Occupational Health and
Safety. Air Monitoring Methods Part III, Vol. 11, Wiley-VCH, Weinheim.
145. Hamann, I., T. Schwerdtle and A. Hartwig (2011) Einfluss von Cadmium und
Kupfer auf Proteine der Basenexzisionsreparatur, in Mikronährstoffe:
Nahrungsergänzingsmittel, Analytik, Essentialität und Toxizität. T. Schwerdtle, F.
Ebert and A. Hartwig (Eds), Utz Verlag, München, 77-82.
144. Ebert, F., I. Hamann, M. Bültemeyer, A. Hartwig, and T. Schwerdtle (2011)
Inhibition of base excision repair by the ultra-trace element arsenite and ist
methylated metabolites in cellular and subcellular systems, in Mikronährstoffe:
Nahrungsergänzingsmittel, Analytik, Essentialität und Toxizität. T. Schwerdtle, F.
Ebert and A. Hartwig (Eds), Utz Verlag, München, 73-76.
143. Großkopf, C., T. Schwerdtle, L.H.F. Mullenders and A. Hartwig (2011)
Toxikologische Aspekte des Ultraspurenelements Antimon, in Mikronährstoffe:
Nahrungsergänzingsmittel, Analytik, Essentialität und Toxizität. T. Schwerdtle, F.
Ebert and A. Hartwig (Eds), Utz Verlag, München, 68-72.
142. Klaus, V., C. Hall, J.Schneider and A. Hartwig (2011) Einfluss von Selen auf die
Integrität des Genoms, in Mikronährstoffe: Nahrungsergänzingsmittel, Analytik,
Essentialität und Toxizität. T. Schwerdtle, F. Ebert and A. Hartwig (Eds), Utz
Verlag, München, 47-50.
141. Jahnke, G. and A. Hartwig (2011) Lebensmittelrelevante Metalle und
Metallverbindungen, in: Steinberg, P und Hamscher, G. (Ed.) Toxikologie in der
praktischen Qualitätssicherung, Sicherheitsrelevante Stoffe in Lebensmitteln,
Behr‘s Verlag, Hamburg, 39-57
140. Hartwig, A. (2011) Polychlorierte Biphenyle (PCB), weltweit verboten – überall
präsent! Gefahrstoffe – Reinhaltung der Luft, 71, 1-2.

2010
139. DFG (2010) MAK- und BAT-Werte-Liste 2010, Mitteilung 46, in deutscher und
englischer Version, Wiley-VCH, Weinheim.
138. Hartwig, A. (2010) Gesundheitsschädliche Arbeitsstoffe - Toxikologischarbeitsmedizinische
Begründungen von MAK-Werten, 48. und 49. Lieferung,
Wiley-VCH, Weinheim.
137. Angerer, J., K -H. Schaller, A. Hartwig (2010) Analytische Methoden zur Prüfung
gesundheitsschädlicher Arbeitsstoffe, Analysen in biologischem Material, 19.
Lieferung, Wiley-VCH, Weinheim.
136. Hartwig, A. (2010) The MAK-Collection for Occupational Health and Safety. MAK
Value Documentations, Part I, Volume 26, Wiley-VCH, Weinheim.
135. Drexler, H., A. Hartwig (2010) The MAK-Collection for Occupational Health and
Safety. BAT Value Documentations, Part II, Volume 5, Wiley-VCH, Weinheim.
134. Angerer, J., A. Hartwig (2010) The MAK-Collection for Occupational Health and
Safety. Biomonitoring Methods, Part IV, Volume 12, Wiley-VCH, Weinheim.
133. Hofmann, A., S. Thierbach, A. Semisch, A. Hartwig, M. Taupitz, E. Rühl and C. Graf
(2010) Highly monodisperse water-dispersable iron oxide nanoparticles for
biomedical applications. J.Mater.Chem. , 20, 7842 – 7853.
132. Schwerdtle T., F. Ebert, C.Thuy, C. Richter, L. H. F. Mullenders and A. Hartwig
(2010) Genotoxicity of soluble and particulate cadmium compounds: Impact
on oxidative DNA damage and nucleotide excision repair. Chem. Res.
Toxicol., 23, 432 – 442.
131. Bornhorst J., F. Ebert, A. Hartwig, B. Michalke and T. Schwerdtle (2010)
Manganese inhibits poly(ADP-ribosyl)ation in human cells: a possible
mechanism behind manganese-induced toxicity. J. Environ. Monit., 12, 2062 –
2069.
130. Klaus, V. , T. Hartmann, J. Gambini, P. Graf, W. Stahl, A. Hartwig and L.-O. Klotz
(2010) 1,4-Naphthoquinones as inducers of oxidative damage and stress
signalling in HaCaT human keratinocytes. Archives of Biochemistry and
Biophysics, 496, 93 – 100.
129. Hartwig. A., T. Schwerdtle and W. Bal (2010) Biophysical analysis of the interaction
of toxic metal ions and oxidants with the zinc finger domain of XPA. Methods
in Molecular Biology, 649, 399 – 408
128. Hartwig A. (2010) Mechanisms in cadmium-induced carcinogenicity: recent
insights. Biometals, 23, 951 – 960.

127. Grosskopf C., T. Schwerdtle, L. H. F. Mullenders and A. Hartwig (2010) Antimony
impairs nucleotide excision repair: XPA and XPE as potential molecular targets.
Chem. Res. Toxicol., 23, 1175 – 1183.
126. Hartwig A. (2010) The role of DNA repair in benzene-induced carcinogenesis.
Chemico-Biological Interactions, 184, 269 – 272.
125. Hartwig, A., T. Schwerdtle and W. Bal (2010) Assessment on the interaction of
toxic metal ions and oxidants with zinc finger proteins involved in maintaining
genomic stability, in: Methods in Molecular Biology, Zinc Finger Proteins:
Methods and Protocols, J. Mackay and D. J. Segal (Eds.), Humana Press Inc.,
399-410.
124. Hartwig, A. (2010) Metalle, in Vohr (Ed.) Toxikologie, Grundlagen der Toxikologie,
Band 1, Wiley VCH, Weinheim,
2009
123. DFG (2009) MAK- und BAT-Werte-Liste 2009, Mitteilung 45 (2009) in deutscher und
englischer Version, Wiley-VCH, Weinheim.
122. Drexler, H., A. Hartwig (2009) Biologische Arbeitsstoff-Toleranzwerte (BAT-Werte)
und Expositionsäquivalente für krebserzeugende Arbeitsstoffe (EKA) –
Arbeitsmedizinisch-toxikologische Begründungen 1-16. Lieferung, Wiley-VCH,
Weinheim.
121. Parlar, H., Angerer, J., Hartwig, A. (2009) Analytische Methoden zur Prüfung
gesundheitsschädlicher Arbeitsstoffe, Luftanalysen 1- 16. Lieferung, Wiley-VCH,
Weinheim.
120. Hartwig, A. (2009) Gesundheitsschädliche Arbeitsstoffe - Toxikologischarbeitsmedizinische
Begründungen von MAK-Werten (2009) 46. und 47.
Lieferung, Wiley-VCH, Weinheim.
119. Hartwig, A. (2009) The MAK-Collection for Occupational Health and Safety. MAK-
Value Documentations Part I, Volume 25, Wiley-VCH, Weinheim.
118. Hartwig, A. (2009) The MAK-Collection for Occupational Health and Safety. Air
Monitoring Methods, Part III, Volume 11, Wiley-VCH, Weinheim.
117. Nollen, M., Ebert F., Moser, J., Mullenders, L.H.F., Hartwig, A., Schwerdtle, T. (2009)
Impact of arsenic on nucleotide excision repair: XPC function, protein level
and gene expression, Molecular Nutrition and Food Research, 53, 572 - 582.
116. Schwerdtle, T. and A. Hartwig (2009) Trendbericht: Aktuelle Beispiele für die
Wirkung von Halbmetallen in Lebensmitteln: Arsen und Selen. Nachrichten aus
der Chemie, 57, 312 – 316.

115. Hamann, I., Schwerdtle, T, and A. Hartwig (2009) Establishment of a
nonradioactive cleavage assay to assess the DNA repair capacity towards
oxidatively damaged DNA in subcellular and cellular systems and the impact
of copper, Mutation Research, 669, 120 – 130.
114. Eastmond, D. A., Hartwig, A., Anderson, D., Anwar, W. A., Cimino, M.C., Dobrev,
I., Douglas, G. R., Nohmi, T., Phillips, D. H. and C. Vickers (2009) Mutagenicity
testing for chemical risk assessment: update of the WHO/IPCS Harmonized
Scheme, Mutagenesis, 24, 341 – 349.
113. WHO International Agency for Research on Cancer Monograph Working Group.
Straif K, Benbrahim-Tallaa L, Baan R, Grosse Y, Secretan B, El Ghissassi F,
Bouvard V, Guha N, Freeman C, Galichet L, Cogliano V; Collaborators: Larsen
PB, Huici-Montagud A, Bateson T, Sams R, Rice F, Schubauer-Berigan M,
Addison J, Bernstein D, Hoskins J, Bird MG, Bochmann F, Bromfield G,
Crosignani P, Deubner D, Eldan M, Gamble J, Goodman J, Grimsrud TK,
Kovalevskiy E, Lemen RA, Morfeld P, Oberdörster G, Neumeister L, Oller A,
Heinrich U, Samet J, Demers PA, Gérin M, Siemiatycki J, Grandjean P, Aitio A,
Kauppinen T, Goldberg M, A Hartwig, Muhle H, Fubini B, Merletti F, Ikeda M,
Attfield MD, Cantor KP, Fowler BA, Henderson R, Infante PF, Kane AB, Landrigan
PJ, Lunn R, Rossman TG, Stayner L, Waalkes MP, Ward EM, Ward JM (2009)
Special Report: Policy. A review of human carcinogens—Part C: metals,
arsenic, dusts, and fibres, The Lancet Oncology, 10, 453 – 454.
112. Piatek, K., A. Hartwig and W. Bal (2009) Physiological levels of glutathione
enhance Zn(II) binding by a Cys4 zinc finger, Biochemical and Biophysical
Research Communications, 389, 265–268.
111. Greim H, A Hartwig, Reuter U, Richter-Reichhelm H-B, Thielmann HW (2009)
Chemically induced pheochromocytomas in rats: Mechanisms and relevance
for human risk assessment. Critical Reviews in Toxicology, 39, 695 – 718.
110. Hartwig, A. Grenzen setzen für den Schutz am Arbeitsplatz. BGFA Info 02/09, 18 –
21
109. Hartwig, A. and T. Schwerdtle (2009) Arsenic-induced carcinogenicity: New
insights in molecular mechanisms, in: Metal Complex-DNA Interactions, N.
Hadjiliadis, E. Sletten (Eds.), Wiley, West Sussex, United Kingdom, 491 – 510.
108. Klaus, V., H. Blessing and A. Hartwig (2009) Einfluss von Selenverbindungen auf
die Zellzykluskontrolle, in: Anwendung und Beudeutung ausgewählter
Spurelemente und Mineralstoffe in der Medizin, T. Stiefel (Editor), UTZ-Verlag,
München, 58 - 62.
107. Hall, C., L-O. Klotz, T. Schwerdtle, A. Hartwig (2009) Interaktion von
Selenverbindungen mit Umweltmutagenen: Untersuchungen zur Beeinflussung
des Fremdstoffmetabolismus und der DNA-Reparatur, in Anwendung und
Bedeutung ausgewählter Spurenelemente und Mineralstoffe in der Medizin, T.
Stiefel (Editor), UTZ-Verlag, München, 53-57.

106. Großkopf, C., T. Schwerdtle and A. Hartwig (2009) Antimon - Interferenz mit der
zellulären Antwort auf DNA-Schädigung, in: Anwendung und Beudeutung
ausgewählter Spurelemente und Mineralstoffe in der Medizin, T. Stiefel (Editor),
UTZ-Verlag, München,110 - 115.
2008
105. DFG (2008) MAK- und BAT-Werte-Liste 2008, Mitteilung 44 in deutscher und
englischer Version, Wiley-VCH, Weinheim.
104. Angerer, J., K -H. Schaller, A. Hartwig (2008) Analytische Methoden zur Prüfung
gesundheitsschädlicher Arbeitsstoffe. Analysen in biologischem Material 1-18.
Lieferung, Wiley-VCH, Weinheim.
103. Briviba, K., Bub, A., Möseneder, J., Schwerdtle, T., Hartwig, A., Kulling, S.,
Watzl, B. (2008) No differences in DNA damage and antioxidant capacity
between intervention groups of healthy, non-smoking men receiving 2, 5 or 8
servings/day of vegetables and fruit, Nutrition and Cancer, 60, 164-70.
102. Smirnova, J., Zhukova, L., Witkiewicz-Kucharczyk, A., Kopera, E., Oledzki, J.,
Wyslouch-Cieszynska, A., Palumaa, P., Hartwig, A., Bal W. (2008) Reaction of
the XPA zinc finger with S-nitrosoglutathione. Chem. Res. Tox., 21, 386-392.
101. Piatek, K., Schwerdtle, T., Hartwig, A., Bal, W. (2008) Monomethylarsonous acid
destroys a tetrathiolate zinc finger much more efficiently than inorganic
arsenite: Mechanistic considerations and consequences for DNA repair
inhibition, Chem. Res. Tox., 21, 600–606.
100. Hockley, S. L., Arlt, V. M., Jahnke, G., Hartwig, A., Giddings, I., Phillips, D. H. (2008)
Identification through microarray gene expression analysis of cellular
responses to benzo[a]pyrene and its diol-epoxide that are dependent or
independent of p53., Carcinogenesis, 29, 202–210.
99. Bochmann, F., Gabriel, S., Hahn, J. U., Hartwig, A., Mittenzwei, V., Rocker, M. (2008)
Hartmetallarbeitsplätze: Exposition und Bewertung. Gefahrstoffe Reinhaltung
der Luft, 68, 7 – 14.
98. Beyersmann, D., Hartwig, A., (2008), Carcinogenic metal compounds: recent
insight into molecular and cellular mechanisms, Arch Toxicol., 82, 493 – 512.
97. Nollen, M., L.H.F. Mullenders, A. Hartwig and T. Schwerdtle (2008) Inhibition of
nucleotide excision repair by arsenicals: molecular targets, Proceedings of the
European Conference on Metallobiolomics Analysis, Function, Clinic Trials, A.
Kyriakopoulos, B., Michalke, A. Graebert, G. Beschnidt (Editors), Herbert Utz
Verlag, München, 151 - 156.

96. Ebert, F., C. Großkopf, A. Hartwig and T. Schwerdtle (2008) Biomethylation of
inorganic arsenic increases arsenic cytotoxicity and genotoxicity in human
lung cells, Proceedings of the European Conference on Metallobiolomics
Analysis, Function, Clinic Trials, A. Kyriakopoulos, B., Michalke, A. Graebert, G.
Beschnidt (Editors), Herbert Utz Verlag, München, 122 - 127.
95. Hamann, I., T. Schwerdtle and A. Hartwig (2008), Application of a non-radioactive
cleavage assay to assess the effect of metal compounds on the repair
capacity towards oxidative DNA damage in human cultured cells,
Proceedings of the European Conference on Metallobiolomics Analysis,
Function, Clinic Trials, A. Kyriakopoulos, B., Michalke, A. Graebert, G. Beschnidt
(Editors), Herbert Utz Verlag, München, 105 - 110.
94. Großkopf, C, T. Schwerdtle, C. Corso and A. Hartwig (2008), Antimony –
Interference with the UVC induced DNA damage response, Proceedings of
the European Conference on Metallobiolomics Analysis, Function, Clinic Trials,
A. Kyriakopoulos, B., Michalke, A. Graebert, G. Beschnidt (Editors), Herbert Utz
Verlag, München, 133 - 138.
93. Hall, C. and A. Hartwig (2008) Interaction of selenium compounds with
environmental mutagens, Proceedings of the European Conference on
Metallobiolomics Analysis, Function, Clinic Trials, A. Kyriakopoulos, B., Michalke,
A. Graebert, G. Beschnidt (Editors), Herbert Utz Verlag, München, 93 - 97.
92. Klaus, Viola, H. Blessing and A. Hartwig (2008), Impact of selenium compounds on
the cell cycle control, Proceedings of the European Conference on
Metallobiolomics Analysis, Function, Clinic Trials, A. Kyriakopoulos, B., Michalke,
A. Graebert, G. Beschnidt (Editors), Herbert Utz Verlag, München, 139 - 143.
2007
91. Smirnova, J., Zhukova, L., Witkiewicz-Kucharczyk, A., Kopera, E., Oledzki, J.,
Wyslouch-Cieszyñska, A., Palumaa, P., Hartwig, A., Bal, W. (2007) Quantitative
electrospray ionization mass spectrometry of zinc finger oxidation: The
reaction of XPA zinc finger with H2O2. Anal Biochem., 369(2), 226-231.
90. Hartwig, A.(2007) Kanzerogene Metallverbindungen: Aktuelle Aspekte zu
Wirkungsmechanismen und Risikobewertung. Schriftenreihe des
Österreichischen Forums Arbeitsmedizin, Facultas Verlags- und Buchhandels
AG, 5-10.
89. Hartwig, A., Pelzer, A., Burnoff, D., Titeca, H., Delincee, H., Bribiba, K., Soika, C.,
Hodapp, C., Raul, F., Miesch, M., Werner, D., Horvatovich, P., Marchioni, E.
(2007) Toxicological potential of 2-alkylcyclobutanones – specific radiolytic

products in irradiated fat-containing food – in bacteria and human cell lines.
Food Chem. Tox, 45, 2581-2591.
88. Schwerdtle, T., Hamann, I., Jahnke, G., Walter, I., Richter, C., Parsons, J.L., Dianov,
G.L., Hartwig, A. (2007) Impact of copper on the induction and repair of
oxidative DNA damage, poly(ADP-ribosyl)ation and PARP-1 activity. Molecular
Nutrition and Food Research, 51, 201-210.
Walter, I., Schwerdtle, T., Thuy, C., Parsons, J.L., Dianov, G.L., Hartwig, A. (2007) Impact
of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene
expression and poly(ADP-ribosyl)ation in cultured human cells. DNA Repair, 87.
6, 61-70.
86. Hartwig, A. (2007) Toxikologisch relevante Stoffe in Lebensmitteln – eine Übersicht,
Handbuch der Lebensmitteltoxikologie, H. Dunkelberg, T. Gebel und. A.
Hartwig (Ed.), Wiley-VCH, Weinheim, Germany, 453 - 458.
85. Hartwig, A. (2007) Zink, Handbuch der Lebensmitteltoxikologie, H. Dunkelberg, T.
Gebel und A. Hartwig (Ed.), Wiley-VCH, Weinheim, Germany, pp. 2247 - 2466.
84. Schwerdtle, T. and A. Hartwig (2007) Arsen, Handbuch der
Lebensmitteltoxikologie, H. Dunkelberg, T. Gebel und. A. Hartwig (Ed.), Wiley-
VCH, Weinheim, Germany, 729 - 756.
83. Schwerdtle, T., I. Hamann, G. Jahnke, C. Richter and A. Hartwig (2007) Oxidative
DNA damage and DNA repair inhibition after copper overload in human cells,
Proceedings of the 5th Fall Conference on Metalloproteins and
Metalloidproteins, A. Kyriakopoulos, B. Michalke, A. Graebert, D. Behne
(Editors), 1-7.
82. Hartwig, A., I. Walter, C. Thuy und T. Schwerdtle (2007) Wirkungsmechanismen von
Arsenverbindungen bei der Krebsentstehung, Mineralstoffe - Molekularbiologie
- Medizin, J. Köhrle und C. Schmutzler (Editors), Herbert Utz Verlag, München,
36-41.
2006
81. Schwerdtle, T. and Hartwig, A. (2006) Bioavailability and genotoxicity of soluble
and particulate nickel compounds in cultured human lung cells. Materials
Science and Engineering Technology, 37, 521-525.
80. Hamann, I., T. Schwerdtle, G. Jahnke and A. Hartwig (2006) Copper overload
decreases genomic stability by distinct mechanisms, Proceedings of the 4th Fall Conference on Metalloproteins and Metalloidproteins, A. Kyriakopoulos, B.
Michalke, A. Graebert, D. Behne (Ed.), Herbert Utz Verlag München, 75-79.

79. Hartwig, A., T. Schwerdtle, H. Blessing, I. Hamann, G. Jahnke, C. Thuy and I. Walter
(2006) Zinkfinger-Proteine als empfindliche Angriffspunkte für toxische
Metallionen und essentielle Spurenelemente, Experimentelle Modelle der
Spurenelementforschung, Schriftenreihe der Gesellschaft für Mineralstoffe und
Spurenelemente e.V., W. Windsch, C. Plitzner (Editors), Herbert Utz Verlag
München, 1-3.
2005
78. ESCODD (2005) Establishing the background level of base oxidation in human
lymphocyte DNA: results of an interlaboratory validation study. The FASEB
Journal, 19(1), 82-84.
77. Berner, Z., Menzel, C., Zeller, A., Eckhardt, J.-D., Stüben, D., Hartwig, A. (2005)
Analytical procedure for the quantification of in vitro Induced Pt- and Pd-DNA
adducts in human lung cells. In: Zereini, F., Alt, F. (Editors) Palladium Emissions in
the Environment. Analytical Methods, Environmental Assessment and Health
Effects. Springer Verlag, pp. 325-341.
76. Hamann, I., T. Schwerdtle, G. Jahnke, H. Blessing, C. Hall, A. Hartwig (2005)
Copper and selenium: essential trace elements with toxicological impact,
Proceedings Vol 2 Euro Food Chem XIII: Macromolecules and their
degradation products in food – physiological, analytical and technological
aspects, 644-647.
75. Schwerdtle, T., I. Walter, A. Hartwig (2005) Arsenic in drinking water: Exposure data,
metabolism in humans and toxicological consequences. Proceedings Vol 2
Euro Food Chem XIII: Macromolecules and their degradation products in food
– physiological, analytical and technological aspects, 640-643.
2004
74. Kopera, E., Schwerdtle, T., Hartwig, A., Bal, W. (2004) Co(II) and Cd(II) substitute for
Zn(II) in the zinc finger derived from the DNA repair protein XPA, demonstrating
a variety of potential mechanisms of toxicity, Chem. Res. Toxicol., 17, 1452 -
1458.
73. Blessing, H., Kraus, S., Heindl, P., Bal, W. and Hartwig, A. (2004) Interaction of
selenium compounds with zinc finger proteins involved in DNA repair,
European Journal of Biochemistry, 271, 3190 - 3199.

72. Burmeister, B., Schwerdtle, T., Poser, I., Müller, W.-U., Rettenmeier, A.W., Hartwig,
A., Seemayer, N.H., Dopp, E. (2004) Effects of asbestos on initiation of DNAdamage,
induction of DNA strand breaks, P53-expression and apoptosis in
primary, SV40-transformed and malignant human mesothelial cells in vitro.
Mutation Research, 558, 81 - 92.
71. Hartwig, A., H. Blessing, T. Schwerdtle and I. Walter (2004) Zinkfingerstrukturen in
DNA-Reparaturproteinen als potentielle Angriffspunkte für toxische
metallionen und essentielle Spurenelemente. Schriftenreihe der Gesellschaft
für mineralstoffe und Spurenelemente e.V., Wissenschaftliche
Verlagsgesellschaft mbH, Stuttgart, 1 – 6.
2003
70. Hartwig, A., A. Pelzer, M. Asmuß and A. Bürkle (2003) Very low concentrations of
arsenite suppress poly(ADP-ribosyl)ation in mammalian cells. Int. J. Cancer,
104, 1 – 6.
69. Bal, W, Schwerdtle, T. and Hartwig, A. (2003) Mechanisms of nickel assault on the
zinc finger of DNA repair protein XPA. Chem. Res. Tox, 16, 242 - 248.
68. ESCODD (2003) Measurement of DNA oxidation in human cells by
chromatographic and enzymic methods. Free Radical Biology and Medicine,
34, 1089 – 1099.
67. Schwerdtle, T., I. Walter, I. Mackiw and A. Hartwig (2003) Induction of oxidative
DNA damage by arsenite and its trivalent and pentavalent methylated
metabolites in cultured human cells and isolated DNA. Carcinogenesis, 24, 967
– 974.
66. Roul, F., F. Gosse, H. Delincee, A. Hartwig, E. Marchioni, M. Miesch, D. Werner and
D. Burnouf (2003) Food-borne radiolytic compounds promote experimental
colon carcinogenesis. Nutrition and Cancer, 44, 189 - 191.
65. Schwerdtle, T., Walter, I. and Hartwig, A. (2003) Arsenite and its biomethylated
metabolites interfere with the formation and repair of stable BPDE-induced
DNA adducts in human cells and impair XPAzf and Fpg. DNA Repair, 2, 1449 -
1463.
64. Hartwig, A., Blessing, H., Schwerdtle, T., Walter, I. (2003) Modulation of DNA repair
processes by arsenic and selenium compounds. Toxicology, 193, 161 - 169.
63. Hartwig, A., T. Schwerdtle and I. Walter (2003), Current aspects on the
genotoxicity of arsenite and its methylated metabolites: Oxidative stress and
interactions with the cellular response to DNA damage. Organic Metal and

2002
Metalloid Species in the Environment. A.V. Hirner, H. Emons (Editors), Springer
Verlag 2003, Berlin / Heidelberg, 221-234.
62. Hartwig, A. (2002) Role of DNA repair in particle- and fiber-induced lung injury.
Inhalation Toxicology, 14, 91 - 100.
61. Schwerdtle, T., A. Seidel and A. Hartwig (2002) Effect of soluble and particulate
nickel compounds on the formation and repair of stable benzo[a]pyrene DNA
adducts in human lung cells. Carcinogenesis, 23, 47 – 53.
60. Hartwig, A. and T. Schwerdtle (2002) Interactions by carcinogenic metal
compounds with DNA repair processes: toxicological implications. Toxicology
Letters, 127, 47 – 54.
59. Hartwig, A., M. Asmuss, H. Blessing, S. Hoffmann, S. Khandelwal, A. Pelzer and A.
Bürkle (2002) Interference by toxic metal ions with zinc-dependent proteins
involved in maintaining genomic stability. Food and Chemical Toxicology, 40,
1179 – 1184.
58. Jensen, B.R. and ESCODD (2002) Comparison of results from different laboratories
in measuring 8-oxo.2'-deoxyguanosine in synthetic oligonucleotides. Free
Radical Research, 36, 239 – 245.
57. ESCODD (2002) Inter-laboratory validation of procedures for measuring 8-oxo-7,8dihydroguanine/8-oxo-7,8-dihydro-2'-deoxyguanosine
in DNA, Free Radical
Research, 36, 239 – 245.
56. Hartwig, A., M. Asmuss, I. Ehleben, U. Herzer, D. Kostelac, A. Pelzer, T. Schwerdtle
and A. Bürkle (2002) Interference by toxic metal ions with DNA repair
processes and cell cycle control: molecular mechanisms. Environmental
Health Perspectives, 110, 797 - 799.
55. Miesch, M., P. Horvatovich, D. Burnouf, H. Delincee, A. Hartwig, F. Raul, D. Werner
and E. Marchioni (2002) Efficient reaction pathway for the synthesis of
saturated and mono-unsaturated 2-alkylcyclobutanones. Radiation Physics
and Chemistry, 65, 233 - 239.
54. Horvatovich, P., F. Raul, M. Miesch, D. Burnouf, H. Delincee, A. Hartwig, D. Werner
and E. Marchioni (2002) Detection of 2-alkylcyclobutanones, markers for
irradiated foods, in adipose tissues of animals fed with these substances, J.
Food Protect., 65, 1610 – 1613.
53. ESCODD (2002) Comparative analysis of baseline 8-oxoguanine in mammalian
cell DNA, by different methods in different laboratories; an approach to
consensus, Carcinogenesis, 23, 2129 – 2133.

52. Raul, F., F. Gossé, H. Delincée, A. Hartwig, E. Marchioni, M. Miesch, D. Werner, and
D. Burnouf (2002) Food-borne radiolytic compounds (2-Alkylcyclobutanones)
may promote experimental colon carcinogenesis. Nutr Cancer, 44, 188–191.
2001
51. Hartwig, A. (2001) Role of magnesium in genomic stability. Mutation Research,
475, 113 - 121.
50. Hartwig, A., P. Kasper, S. Madle, G. Speit, F. Staedtler and C. Sengstag. (2001) The
potential use of mutation spectra in cancer releated genes in genetic
toxicology: a statement of a GUM working group. Mutation Research, 473, 263
– 267.
49. Hartwig, A. (2001) Zinc finger proteins as potential targets for toxic metal ions:
Differential effects on structure and function. Antioxidants and Redox
Signaling, 3, 625 – 634.
48. Merzenich, M., A. Hartwig, W. Ahrens, D. Beyersmann, M. Scholze, J. Timm and K.-
H. Jöckel (2001) Biomonitoring on carcinogenic metals and oxidative DNA
damage in a cross-sectional study. Cancer Epidemiology, Biomarker and
Prevention, 10, 515 – 522.
47. Greim, H., P. Borm, R. Schins, K. Donaldson, K. Driscoll, A. Hartwig, E. Kuempel, G.
Oberdörster and G. Speit (2001) Toxicity of fibers and particles – Report of the
workshop held in Munich, Germany, October 26 – 27, 2000, Inhalation
Toxicology, 13, 737 – 754.
2000 and older
46. Asmuß, M., L.H.F. Mullenders and A. Hartwig (2000) Interference by toxic metal
compounds with isolated zinc finger DNA repair proteins. Toxicology Letters,
112 – 113, 227 - 231.
45. Hartwig, A. (2000) Metallionen zwischen Essentialität und Toxizität. Chemie in
unserer Zeit, 34, 224 - 231.
44. Hartwig, A. (2000) Recent advances in metal carcinogenicity. Pure Appl. Chem.,
72, 1007 – 1014.
43. Asmuss, M, L.H:F. Mullenders, A. Eker and A. Hartwig (2000) Differential effects of
toxic metal compounds on the activities of Fpg and XPA, two zinc finger
proteins involved in DNA repair. Carcinogenesis, 21, 2097 - 2104.

42. Hartwig, A., U.D. Gröblinghoff, Y. Hiemstra, L.H.F. Mullenders (2000) Inhibition of
DNA repair processes by inorganic arsenic. In: Eisenbrand, G., Dayan, A. D.
Elias, P. S., Grunow, W., and J. Schlatter (Eds.) Carcinogenic and
Anticarcinogenic Factors in Food, Wiley- VCH, pp 478 - 481.
41. Krüger, I., L.H.F. Mullenders and A. Hartwig (1999) Nickel(II) increases the sensitivity
of V79 Chinese hamster cells towards cisplatin and transplatin by interference
with distinct steps of DNA repair. Carcinogenesis, 20, 1177 – 1184.
40. Beyersmann, D. and A. Hartwig (1999) Kombinationswirkungen bei
krebserzeugenden Metallverbindungen. ErgoMed, 23, 170 – 175.
39. Hartwig, A., L.H.F. Mullenders, M. Asmuß, M. Benters and I. Krüger (1999) Effect of
metal compounds on the function oft zinc finger proteins involved in DNA
repair. In: B. Sarkar (Ed.) Metals and Genetics, Kluwer Academic, New York,
pp. 159 - 169.
38. Nilsson, R., A.T. Natarajan, A. Hartwig, F. Dulout, M.E. De la Rosa, M. Vahter (1999)
Clastogenic effects and influence of inorganic arsenic on DNA repair in
mammalian systems. In: B. Sarkar (Ed.) Metals and Genetics, Kluwer
Academic, New York, pp. 21 – 40.
37. Jöckel, K.-H., W. Ahrens, H. Merzenich, I. Jahn, S. Wolf, A. Hartwig, D. Beyersmann,
M. Scholze and J. Timm (1999) Integrierter Ansatz zum Risikomonitoring. In:
Deutsche Gesellschaft für Public Health e.V. (Hrsg.) Public-Health-Forschung in
Deutschland. Verlag Hans Huber, Bern, pp. 124 – 126.
36. Hartmann, M. and A. Hartwig (1998) Disturbance of DNA damage recognition
after UV-irradiation by nickel(II) and cadmium(II) in mammalian cells,
Carcinogenesis, 19, 617 - 621.
35. Calevro, F., D. Beyersmann and A. Hartwig (1998) Effect of cadmium(II) on the
extent of oxidative DNA damage in primary brain cell cultures from
Pleurodeles larvae. Toxicology Letters, 94, 217 - 225.
34. Hartwig, A., L.H.F. Mullenders, M. Asmuß, H. Dally, M. Hartmann (1998) Disruption of
DNA repair processes by carcinogenic metal compounds. Fresenius J. Anal.
Chem., 361, 377 - 380.
33. Iwitzki, F., R. Schlepegrell, U. Eichhorn, B. Kaina, D. Beyersmann and A. Hartwig
(1998) Nickel(II) inhibits the repair of O6-methylguanine in mammalian cells.
Achives of Toxicology, 72, 681 - 689.
32. Hartwig, A., L.H.F. Mullenders, M. Asmuß, H. Dally, M. Hartmann (1998) Disruption of
DNA repair processes by carcinogenic metal compounds. Fresenius J. Anal.
Chem., 361, 377 - 380.
31. Hartwig, A. (1998) Carcinogenicity of metal compounds: possible role of DNA
repair inhibition. Toxicology Letters, 102 - 103, 235 - 239.
30. Hartwig, A. (1998) Assessment of oxidative DNA damage by the frequency of
formamidopyrimidine DNA glycosylase (FPG) sensitive DNA lesions, in: B.

Halliwell and O.I. Aruoma (eds), DNA and free radicals, OICA International,
Saint Lucia, London, pp. 215 - 223.
29. Hartwig, A., U. D. Gröblinghoff, D. Beyersmann, A.T. Natarajan, R. Filon and L.H.F.
Mullenders (1997) Interaction of arsenic(III) with nucleotide excision repair in
UV-irradiated human fibroblasts. Carcinogenesis, 18, 399 - 405.
28. Kasten, U., L.H.F. Mullenders and A. Hartwig (1997) Cobalt(II) inhibits the incision
and the polymerization step of nucleotide excision repair in human fibroblasts,
Mutation Research, 383, 81 -89.
27. Dally, H. and A. Hartwig (1997) Induction and repair inhibition of oxidative DNA
damage by nickel(II) and cadmium(II) in mammalian cells, Carcinogenesis, 18,
1021 - 1026.
26. Beyersmann, D. and A. Hartwig (1997) Cellular effects of cadmium: Interference
with DNA repair and gene regulation, in: U. Mohr, D.L. Dungworth, K.B. Adler,
C.C. Harris, and C.G. Plopper (Eds.) Correlations between In Vitro and In Vivo
Investigations in Inhalation Toxicology, ILSI Press, Washington D.C, pp. 380 - 392.
25. Hartwig, A., R. Schlepegrell and D. Beyersmann (1996) Analysis of metal-induced
oxidative DNA damage in cultured mammalian cells, Fresenius J. Anal. Chem.,
354, 606 - 608.
24. Hartwig, A., R. Schlepegrell, H. Dally and M. Hartmann (1996) Interaction of
carcinogenic metal compounds with DNA repair processes. Annals of Clinical
and Laboratory Science, 26, 31-38.
23. Hartwig, A., H. Dally and R. Schlepegrell (1996) Sensitive analysis of oxidative DNA
damage in mammalian cells: Use of the bacterial Fpg protein in combination
with alkaline unwinding. Toxicology Letters, 88, 85 - 90.
22. Kasten, U., D. Beyersmann, J. Dahm-Daphi and A. Hartwig (1995) Sensitive
nonradioactive detection of UV-induced pyrimidine dimers in intact
mammalian cells, Mutation Research, 336, 143 - 152.
21. Hartwig, A. (1995) Current aspects in metal genotoxicity, BioMetals, 8, 3 - 11.
20. Hartwig, A. and R. Schlepegrell (1995) Induction of oxidative DNA damage by
ferric iron in mammalian cells, Carcinogenesis, 16, 3009 - 3013.
19. Hartwig, A. (1994) Role of DNA repair inhibition in lead- and cadmium-induced
genotoxicity: A review, Environmental Health Perspectives, 102, Suppl. 3, 45 -
50.
18. Hartwig, A., I. Krüger and D. Beyersmann (1994) Mechanisms in nickel
genotoxicity: The significance of interactions with DNA repair, Toxicology
Letters, 72, 353 - 358.
17. Hartwig, A., L.H.F. Mullenders, R. Schlepegrell, U. Kasten and D. Beyersmann (1994)
Nickel(II) interferes with the incision step in nucleotide excision repair, Cancer
Res., 54, 4045 - 4051.

16. Beyersmann, D. and A. Hartwig (1994) Genotoxic effects of metal compounds,
Archives of Toxicology, Suppl. 16, Use of mechanistic information in risk
assessment, Proceedings of the 1993 Eurotox Congress, Uppsala, 30.6.-3.7.1993,
Springer Verlag, Berlin, pp. 192 - 198.
15. Hartwig, A., L.H.F. Mullenders, R. Schlepegrell, I. Krueger and D. Beyersmann
(1994) Interaction of Nickel(II) with DNA repair processes: Inhibition of the
Incision step in nucleotide excision repair, in: P. Collery, L.A. Poirier, N.A.
Littlefield, J.-C. Etienne (Eds.) Metal Ions in Biology and Medicine, Vol. 3,
Proceedings of the Third International Symposium on Metal Ions in Biology held
in Montreal, Canada, May 17 - 21, 1994, John Libbey Eurotext, Paris, pp. 235 -
240.
14. Hartwig, A., H. Klyszcz-Nasko, R. Schlepegrell and D. Beyersmann (1993) Cellular
damage by ferric nitrilotriacetate and ferric citrate in V79 cells:
interrelationship between lipid peroxidation, DNA strand breaks and sisterchromatid
exchanges, Carcinogenesis, 14, 107 - 112.
13. Beyersmann, D. and A. Hartwig (1992) The genetic toxicology of cobalt, Toxicol.
Applied Pharmacol., 115, 137 - 145.
12. Kasten, U., A. Hartwig and D. Beyersmann (1992) Mechanisms of Co(II) uptake into
V79 Chinese hamster cells, Arch. Toxicol., 66, 592 - 597.
11. Hartwig, A., R. Schlepegrell and D. Beyersmann (1992) Interactions in nickel
mutagenicity: Indirect mechanisms in genotoxicity and interactions with DNA
repair, in: E. Merian, W. Haerdi (Eds.) Metal Compounds in Environment and
Life 4, Science and Technology Letters, Northwood, pp. 475 - 480.
10. Hartwig, A., R. Schlepegrell, J. Kuhlmann, J. Benters and D. Beyersmann (1992)
Genotoxicity of Fe(III)-NTA and its interaction with other carcinogenic metal
compounds, in: N.H. Seemayer, W. Hadnagy (Eds.) Environmental Hygiene III,
Springer Verlag, Berlin - Heidelberg, pp. 79 - 82.
9. Hartwig, A., R.D. Snyder, R. Schlepegrell and D. Beyersmann, D. (1991) Modulation
by Co(II) of UV-induced DNA repair, mutagenesis and sister-chromatid
exchanges in mammalian cells, Mutation Res., 248, 177-185.
8. Hartwig, A., R. Schlepegrell and D. Beyersmann (1990) Indirect mechanism of leadinduced
genotoxicity in cultured mammalian cells, Mutation Res., 241, 75 - 82.
7. Hartwig, A., Kasten, U., Boakye-Dankwa, K., Schlepegrell, R. and D. Beyersmann
(1990) Uptake and genotoxicity of micromolar concentrations of cobalt
chloride in mammalian cells, Toxicol. Environ. Chem., 28, 205 - 215.
6. Hartwig, A., R. Schlepegrell and D. Beyersmann (1990) Lead(II) interferes with the
repair and processing of UV-induced DNA damage, in: N.H. Seemayer, W.
Hadnagy (Eds.) Environmental Hygiene II, Springer Verlag, Berlin - Heidelberg,
pp. 65 - 68.

5. Beyersmann, D., A. Hartwig and A. Kortenkamp (1990) Mutagenicity of
carcinogenic metal compounds: Molecular mechanisms, in: N.H. Seemayer,
W. Hadnagy (Eds.) Environmental Hygiene II, Springer Verlag, Berlin -
Heidelberg, pp. 57 - 60.
4. Hartwig, A. and D. Beyersmann (1989) Enhancement of UV-induced mutagenesis
and sister-chromatid exchanges by nickel ions in V79 cells: evidence for
inhibition of DNA repair, Mutation Res. 217, 65 - 73.
3. Hartwig, A. and D. Beyersmann (1989) Comutagenicity and inhibition of DNA repair
by metal ions in mammalian cells, Biol. Trace Element Res. 21, 359 - 365.
2. Zelikoff, J.T., J.H. Li, A. Hartwig, X.W. Wang, M. Costa and T.G. Rossman (1988)
Genetic toxicology of lead compounds, Carcinogenesis, 9, 1727 - 1732.
1. Hartwig, A. and D. Beyersmann (1987) Enhancement of UV and chromate
mutagenesis by nickel ions in the Chinese hamster HGPRT assay, Toxicol.
Environ. Chem., 14, 33 - 39.
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