Nanogen - PharmXpert Academy

The skin cancer
cure (the treatment
of choice for nonmelanoma
skin
cancers)
By Bill Cham, Ph.D.
The laws of nature may be considered as; ‘the forces and
processes that produce and control all the phenomena of the
material world.’
The sun is a major force in nature and is essential for life on
earth; unfortunately the sun also produces some unwanted sideeffects
for humans.
It is fashionable to have a suntan and people feel that exposing
their skin to the sun is a healthy, pleasant thing to do. However,
the sun also has a ‘dark side’ in that, the ultraviolet part of
the electromagnetic spectrum produced by the sun as light, in
particular U.V.-B (290-320nm), is responsible for producing
long-term solar skin damage (keratosis) and skin cancers. In
fact, skin cancers are the most common malignancy in humans.
BEC5 Curaderm® is a topical cream
preparation of a mixture of the glycoalkaloids
solasodine glycosides (BEC). BECs are
present in some solanaceous plants, including
edible plants such as Solanum melongena,
(otherwise known as eggplant or aubergine).
Now, BEC is available to the public for the
treatment of cutaneous solar keratosis, basal
cell carcinoma (BCC) and squamous cell
carcinoma (SCC).
This communication gives us some insight how, on the one
hand, nature through one of its major forces- sun light, is
causing increasingly higher incidences of human skin cancers
but, on the other hand, nature, also with the involvement
of sunlight and plants has supplied the solution on how to
eradicate these skin cancers.
The etiologies of keratosis, BCC and SCC, their currently
available treatments, and the particular attributes of Curaderm-
BEC5 within these concepts of pathogenesis and therapeutics,
are presented in this article.
Keratosis
An overgrowth of the epidermis forms a scaly layer on the
skin. The start of this lesion is usually a small patch of dilated
capillaries several millimetres in diameter. Then a dry, rough,
adherent yellow or dirty brown scale forms, which may bleed
if picked off. It may eventually become thick and horny, with
a sharp, clear division between the keratosis and normal skin.
Solar keratoses occasionally regress if sun exposure is stopped
before they become too established. Although non-malignant,
they are potentially malignant and can develop into cancer.
Basal Cell Carcinoma (BCC)
A BCC is a malignant tumour that rarely spreads to distant
sites (metastasises). It starts in the basal layer of cells, between
the basement membrane and the subsequent layer of cells
and grows upwards from these. It consists of immature cells
and has an organized complex of supportive tissue around it.
The primary cause of BCC is sunlight exposed onto sensitive
skin. Contributory causes are radiation damage, exposure to
arsenic, burn scars and vaccination marks. BCCs are the most
common malignant skin tumours in humans; they do not spread
by metastases, but they erode tissue, and if not treated may
eventually kill. BCCs may appear in a variety of guises and
on first appearance; they are commonly small, rounded lumps
with a pearly edge, and a thin surface covering with a few
superficial transparent blood vessels. BCCs may also appear
as ulcers, or as bleeding or non-healing lesions. Occasionally
they appear as flat diffuse crusting or scaling red lesions. BCC
tumours usually grow slowly but in a relentless manner. They
then ulcerate and the ulcer will follow the spreading tumour,
causing further damage, (for this reason they are also known as
rodent ulcers).
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