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Mediterranean Journal of Medical Sciences,aims to provide a platform for knowledge sharing among academicians, students, researchers, physicians, government entities and other non government entities.
Issues : 3 per year
ISSN 2385-2712 EISSN 2385-2453
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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> Volume 1, Issue 1, October 2014: 1-5<br />
Original Paper<br />
Screening Program for Proteinuria in Rural Adult<br />
Population: Kirsehir, Turkey<br />
Mehmet ÖZDEMIR*, Gülay AKGÜL*<br />
*Ahi Evran University Training and Research Hospital, Kirsehir, Turkey<br />
Background & objectives: The burden <strong>of</strong> kidney disease is disproportionately high in central<br />
Anatolia, and the conditions <strong>of</strong>ten remain undiagnosed until late-stage disease. In order to<br />
reduce this burden, strategies must be implemented to improve the detection <strong>of</strong> kidney disease,<br />
and preventative measures must be targeted at those at greatest risk <strong>of</strong> disease. Important<br />
risk factors among include hypertension, diabetes, and obesity. As the exact prevalence <strong>of</strong><br />
proteinuria is not known in the general population, we undertook this study to estimate the<br />
same in a rural adult population in Kirsehir district.<br />
Methods: A survey <strong>of</strong> health and health related issues was conducted on 2524 volunteers,<br />
average age 52.19 years, selected randomly from the Kirsehir District, Turkey. A dipstick<br />
urinalysis and test for Proteinuria was performed on a clean void, untimed urine sample as a<br />
part <strong>of</strong> a 4-hour interview/examination. Ultrasound <strong>of</strong> the abdomen was done in patients<br />
with renal failure and renal biopsy was performed in selected patients.<br />
Results: Of the total 2524 individuals screened, 61.3 per cent were females. Mean age <strong>of</strong> the<br />
study population was 51.19 ± 11.2 yr. First dipstick test identified 289 individuals positive for<br />
albuminuria. Repeat dipstick could be done in only 263, <strong>of</strong> whom 117 showed persistent<br />
albuminuria. Significant proteinuria was detected in 14 individuals <strong>of</strong> the 208 who had 24 h<br />
urine protein measured. Of these 14 patients, 3 were found to have chronic renal failure, 6<br />
were presumed to have diabetic nephropathy clinically, one each had focal segmental<br />
glomerulosclerosis and biopsy proven diabetic nephropathy, and 4 patients had proteinuria <strong>of</strong><br />
unknown aetiology.<br />
Interpretation & conclusion: The prevalence <strong>of</strong> proteinuria in this adult rural population was<br />
0.47 per cent (0.30-0.67%) and Males were more affected than females. The detection and<br />
treatment <strong>of</strong> chronic kidney disease in 14 individuals is bound to reduce the rate <strong>of</strong> decline <strong>of</strong><br />
renal functions.<br />
Key words Albuminuria - dipstick - endstage renal disease - proteinuria<br />
1. Introduction<br />
Proteinuria is defined as urinary<br />
protein excretion <strong>of</strong> greater than<br />
150 mg per day. Urinary protein<br />
excretion in healthy persons<br />
varies considerably and may reach<br />
proteinuric levels under several<br />
circumstances. Most dipstick tests<br />
(e.g., Albustin, Multistix) that are
<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 1-5 2<br />
positive for protein are a result <strong>of</strong><br />
benign proteinuria, which has no<br />
associated morbidity or<br />
mortality[5] . Among the various<br />
predictors <strong>of</strong> progression <strong>of</strong><br />
chronic kidney disease to end<br />
stage renal disease (ESRD),<br />
proteinuria is the most potent<br />
predictor[6]. Angiotensin<br />
converting enzyme (ACE)<br />
inhibitors (ACEi) and angiotensin<br />
II receptor blockers (ARB) have<br />
been given to persons with<br />
proteinuria and chronic kidney<br />
disease to decrease the progression<br />
to end stage renal disease[4,7-11],<br />
treatment <strong>of</strong> proteinuric patients<br />
with ACEi and ARB has been<br />
shown to decrease the rate <strong>of</strong><br />
progression <strong>of</strong> chronic kidney<br />
disease.<br />
Since the exact prevalence and<br />
cause <strong>of</strong> proteinuria as a marker <strong>of</strong><br />
kidney disease is not known in<br />
our population, we undertook this<br />
study to estimate the same in a<br />
rural population in Kirsehir.<br />
2. Material & Methods<br />
A convenient sample <strong>of</strong> 2524<br />
adults (aged 40 yr and above)<br />
from rural area <strong>of</strong> Kirsehir, Turkey<br />
was included in the study. The<br />
study was carried out for a period<br />
<strong>of</strong> 24 months between April 2011<br />
and April 2013. Individuals were<br />
selected under an ongoing<br />
community health programme by<br />
the Department <strong>of</strong> Urology, Ahi<br />
Evran University Training and<br />
Research Hospital, Kirsehir,<br />
Turkey.<br />
After explaining about the<br />
objective <strong>of</strong> the study, individuals<br />
were tested for albuminuria by<br />
dipstick examination (Multistix<br />
SG, Bayer Diagnostics) in an<br />
untimed urine sample. Individuals<br />
who had acute illness, non<br />
ambulatory persons and<br />
menstruating women were<br />
excluded. Individuals tested<br />
positive for albuminuria<br />
underwent a second dipstick<br />
examination after a gap <strong>of</strong> one<br />
week. Repeat dipstick was<br />
performed to rule out transient<br />
proteinuria.<br />
Individuals with persistent<br />
albuminuria on the second<br />
dipstick examination underwent<br />
further evaluation at the which<br />
included medical history, physical<br />
examination, 24 h urine protein<br />
estimation, total serum protein<br />
and albumin estimation. Those<br />
who had proteinuria (protein<br />
excretion >150 mg/day on 24 h<br />
urine protein estimation)<br />
underwent urine microscopic<br />
examination, blood urea and<br />
serum creatinine, fasting and<br />
postprandial blood sugar level<br />
estimations. Ultrasound <strong>of</strong> the<br />
abdomen was done in patients<br />
with renal failure (serum<br />
creatinine >1.4 mg/dl). Renal<br />
biopsy was performed in patients<br />
with proteinuria >1 g/day or<br />
©2014 <strong>Mediterranean</strong> Center <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong>
M. ÖZDEMIR, G. AKGÜL 3<br />
proteinuria with an active urinary<br />
sediment or with renal failure. To<br />
facilitate the participation,<br />
dipstick examination for<br />
albuminuria was performed at the<br />
individual’s residence.<br />
3. Results & Discussion<br />
Of a total <strong>of</strong> 2524 individuals<br />
screened, 1548 (61.3%) were<br />
women. The age ranged from 40<br />
to 90 yr with a mean age <strong>of</strong> 51.19 ±<br />
11.2 yr. First dipstick test<br />
identified 59 individuals with<br />
positive for albuminuria. Of these,<br />
repeat dipstick could be done in 57<br />
diabetic nephropathy clinically<br />
(diabetics with proteinuria,<br />
diabetic retinopathy and inactive<br />
urinary sediment). Seven patients<br />
who had proteinuria <strong>of</strong> unknown<br />
aetiology, were not subjected to<br />
renal biopsy as criteria for biopsy<br />
were not met (proteinuria <strong>of</strong> less<br />
than 1 g/day, normal renal<br />
function and bland urinary<br />
sediment). Two patients<br />
underwent renal biopsy and it<br />
showed focal segmental<br />
glomerulosclerosis in one and<br />
diabetic nephropathy in the other<br />
The following thresholds have<br />
been considered, as summarised<br />
here:<br />
Table 1<br />
ACR<br />
PCR Implication<br />
(mg/mmol) (mg/mmol)<br />
>2.5/3.5 >15 Abnormal (ACR values are for male, female):<br />
adequate to define CKD 1 or 2.<br />
Commence ACEI/ARB if diabetic(**).<br />
30 50 Favour ACE inhibitor/ ARB if hypertensive<br />
Suffix 'p' on CKD stage<br />
70 100<br />
Referral threshold in non-diabetics<br />
>250 >300 Approximately 'nephrotic range' proteinuria<br />
individuals <strong>of</strong> whom 21 showed<br />
persistent<br />
albuminuria.<br />
Significant proteinuria was<br />
detected in 14 (8 males, 6 females)<br />
<strong>of</strong> the 20 individuals with<br />
persistent albuminuria who had 24<br />
h urine protein measured. Further<br />
evaluation <strong>of</strong> these 20 subjects<br />
revealed chronic renal failure in<br />
three by biochemical and<br />
ultrasound examinations. Twelve<br />
patients were presumed to have<br />
The prevalence <strong>of</strong> proteinuria in<br />
the study population was 0.47 per<br />
cent (0.30-0.67%) using albumin<br />
dipstick as a screening test.<br />
Prevalence in males and females<br />
was 0.75 per cent (0.35-1.14%) and<br />
0.31 per cent (0.11-0.50%)<br />
respectively (Table 2).<br />
The female preponderance in the<br />
study sample was probably a<br />
reflection <strong>of</strong> the fact that the men<br />
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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 1-5 4<br />
were away from home at work<br />
during the time <strong>of</strong> sample<br />
collection. Among the various<br />
aetiological factors, diabetic<br />
nephropathy was found in 7 <strong>of</strong> 14<br />
patients (50%) with proteinuria.<br />
Seven patients with significant<br />
proteinuria not meeting the<br />
criteria for a renal biopsy are<br />
being followed up. Patients with<br />
diabetic nephropathy were<br />
advised euglycaemic measures and<br />
are on follow up with the health<br />
department. One individual with<br />
focal<br />
segmental<br />
glomerulosclerosis was treated<br />
parts <strong>of</strong> the country may prove to<br />
be an effective measure in<br />
reducing the burden <strong>of</strong> chronic<br />
kidney disease.<br />
Acknowledgment<br />
The authors thank trained health<br />
care workers at Ahi Evran<br />
University Training and Research<br />
Hospital, Kirsehir, Turkey for<br />
their assistance in performing<br />
urine dipstick examination.<br />
Table 2. Prevalence rate <strong>of</strong> proteinuria (%) according to age and gender<br />
Age Males Females<br />
(yr) (N) Prevalence (N) Prevalence<br />
40-59 621 0.60 (0.58 - 0.62) 1050 0.62 (0.61 - 0.64)<br />
60-79 319 0.32 (0.30 - 0.34) 441 0.35 (0.347 -0.349)<br />
>80 36 0.07 (0.06 - 0.09) 57 0.03 (0.027 -0.029)<br />
Total 976 1548<br />
Values in parentheses indicate range<br />
with ACEi and has stable renal<br />
function. The risk <strong>of</strong> renal failure<br />
is greater in younger patients.<br />
In conclusion, although the<br />
prevalence <strong>of</strong> proteinuria in this<br />
rural population was low,<br />
detection and treatment <strong>of</strong> chronic<br />
kidney disease in 14 individuals<br />
with proteinuria is likely to reduce<br />
the rate <strong>of</strong> decline <strong>of</strong> renal<br />
function. Similar screening<br />
programmes for proteinuria with<br />
proper study design in different<br />
References<br />
1. Nakopoulou L, Stefananki K, Papadakis<br />
J,Boletis J, Zeis PM, Kostakis A et<br />
al. Expression <strong>of</strong> bcl-2 oncoprotein<br />
in various types <strong>of</strong><br />
glomerulonephritis and renal<br />
allografts. Nephrol Dial Transplant<br />
1996; 11: 997–1002<br />
2. Gerstein HC, Mann JF, Yi Q, et al.<br />
Albuminuria and risk <strong>of</strong><br />
cardiovascular events, death, and<br />
heart failure in diabetic and<br />
nondiabetic individuals. JAMA 2001;<br />
286 : 421-6.<br />
©2014 <strong>Mediterranean</strong> Center <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong>
M. ÖZDEMIR, G. AKGÜL 5<br />
3. James PA, Oparil S, Carter BL, et al. 2014<br />
evidence-based guideline for the<br />
management <strong>of</strong> high blood pressure<br />
in adults—report from the panel<br />
members appointed to the Eighth<br />
Joint National Committee (JNC 8).<br />
The <strong>Journal</strong> <strong>of</strong> the American <strong>Medical</strong><br />
Association. Published online<br />
December 18, 2013.<br />
4. Anastasio, P, Spitali, L, Frangiosa, A,<br />
Molino, D, Stellato, D, Cirillo, E,<br />
Pollastro, RM, Capodicasa, L, Sepe,<br />
J, Federico, P, Gaspare De Santo, N<br />
(2000) Glomerular filtration rate in<br />
severely overweight normotensive<br />
humans. Am J Kidney Dis 35 (6)<br />
1144-1148.<br />
5. Lindholm LH, Ibsen H, Dahl<strong>of</strong> B, et al.<br />
Cardiovascular morbidity and<br />
mortality in patients with diabetes<br />
in the Losartan Intervention For<br />
Endpoint Reduction in<br />
Hypertension Study (LIFE): a<br />
randomised trial against atenolol.<br />
Lancet 2002; 359 : 1004-10.<br />
6. Jafar TH, Schmid CH, Landa M, et al.<br />
Angiotensin-converting enzyme<br />
inhibitors and progression <strong>of</strong><br />
nondiabetic renal disease: a metaanalysis<br />
<strong>of</strong> patient-level data. Ann<br />
Intern Med 2001; 135 : 73-87.<br />
7. Uluhan A, Paydaş S, Sağlıker Y, Demirtaş<br />
M, Bozdemir H, Sarıca Y: Low<br />
blood pressure and amyloidosis.<br />
Nephron 1995; 69: 118-119<br />
8. Agodoa LY, Appel L, Bakris GL, et al.<br />
Effect <strong>of</strong> ramipril vs amlodipine on<br />
renal outcomes in hypertensive<br />
nephrosclerosis: a randomized<br />
controlled trial. JAMA 2001; 285 :<br />
2719-28.<br />
9. Lewis EJ, Hunsicker LG, Clarke WR, et al.<br />
Renoprotective effect <strong>of</strong> the<br />
angiotensin-receptor antagonist<br />
irbesartan in patients with<br />
nephropathy due to type 2 diabetes.<br />
N Engl J Med 2001; 345 : 851-60.<br />
10. Brenner BM, Cooper ME, de Zeeuw D, et<br />
al. Effects <strong>of</strong> losartan on renal and<br />
cardiovascular outcomes in patients<br />
with type 2 diabetes and<br />
nephropathy. N Engl J Med 2001; 345<br />
: 861-9.<br />
11. Saatçi Ü, Özdemir S, Özen S, Bakkaloğlu<br />
A: Serum concentration and urinary<br />
excretion <strong>of</strong> beta 2 microglobulin<br />
and microalbuminuria infamilial<br />
<strong>Mediterranean</strong> fever. Arch Dis<br />
Child 1994; 70: 27-29<br />
12. Aktuğ H, Çetintaş VB, Kosova B, Oltulu<br />
F, Demiray ŞB, Çavuşoğlu T et al.<br />
Dysregulation <strong>of</strong> nitric oxide<br />
synthase activity and Bcl-2 and<br />
caspase-3 gene expressions in renal<br />
tissue <strong>of</strong> streptozotocin-induced<br />
diabetic rats. Turk J Med Sci 2012;<br />
42: 830–8<br />
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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> Volume 1, Issue 1, October 2014: 7-12<br />
Original Paper<br />
Urinary Tract Infections (UTI) Among Patients at the<br />
University Hospital Center "Mother Theresa", Tirana,<br />
Albania.<br />
Selam Shkurti*<br />
*Department <strong>of</strong> Emergency, University Hospital Center "Mother Theresa", Tirana, Albania.<br />
Abstract<br />
Background & objectives: The resistance <strong>of</strong> bacteria causing urinary tract infection (UTI) to<br />
commonly prescribed antibiotics is increasing both in developing as well as in developed<br />
countries. Resistance has emerged even to more potent antimicrobial agents. The primary<br />
objective <strong>of</strong> the study was 1) to detect the prevalence rate <strong>of</strong> bacterial infection among urinary<br />
isolates from patients having UTI and 2)to detect prevalence rate <strong>of</strong> drug resistance among<br />
pathogen isolate from patients having UTI.<br />
Methods: Early morning mid-stream urine samples were collected using sterile, wide<br />
mouthed container with screw cap tops. On the urine sample bottles were indicated name, age,<br />
sex, and time <strong>of</strong> collection along with requisition forms.<br />
Results:. Significant association (P
<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 7-12 8<br />
least 59% <strong>of</strong> cases. Other less<br />
common pathogens include<br />
Klebsiella, Proteus, Enterobacter<br />
spp, etc.<br />
To be mentioned that the<br />
distribution <strong>of</strong> pathogens that<br />
cause UTI is changing. There are<br />
several factors and abnormalities<br />
<strong>of</strong> UTI that interfere with its<br />
natural resistance to infections.<br />
These factors include sex and age<br />
disease, hospitalization and<br />
obstruction in urinary tract.<br />
The treatment <strong>of</strong> UTIs varies<br />
according to the age <strong>of</strong> the patient,<br />
sex, underlying disease, infecting<br />
agent and whether there is lower<br />
or upper urinary tract<br />
involvement. Diagnosis <strong>of</strong> UTI<br />
<strong>of</strong>ten requires laboratory<br />
examination <strong>of</strong> a urine sample in<br />
addition to clinical evaluation.<br />
Although many guidelines<br />
indicate that the culture <strong>of</strong> urine is<br />
not required in most cases <strong>of</strong><br />
uncomplicated cystitis[1], the<br />
laboratory in UHC Mother<br />
Teresa, accepts all such requests<br />
from patients to send samples on<br />
all suspected UTI.<br />
With the increasing trend <strong>of</strong><br />
antibiotic-resistance in E. coli, the<br />
management <strong>of</strong> urinary tract<br />
infections is likely to become<br />
complicated with limited<br />
therapeutic options.<br />
2. Material & Methods<br />
Study site: The study was carried<br />
out in the Department <strong>of</strong><br />
Emergency, University Hospital<br />
Center "Mother Theresa", Tirana,<br />
Albania from November 2006 to<br />
September 2007.<br />
This was an analysis <strong>of</strong> data<br />
generated from the records <strong>of</strong><br />
consecutive urine samples<br />
received in the laboratory during<br />
the study period.<br />
Analysis <strong>of</strong> the data was carried<br />
out focusing on the age, gender,<br />
whether admitted or not, whether<br />
received prior antibiotic therapy,<br />
any surgical or gynaecological<br />
intervention performed in the<br />
recent past, and any history <strong>of</strong><br />
urinary tract infection in the past.<br />
The antibiotic susceptibility data<br />
<strong>of</strong> all isolates were also reviewed<br />
and analyzed. Samples received<br />
included mid-stream clean catch<br />
urine, suprapubic aspirate, urine<br />
collected from Foley’s catheter<br />
and from the nephrostomy tube<br />
under sterile precautions, in<br />
patients who had undergone<br />
percutaneous nephrostomy.<br />
Samples were processed and<br />
isolates were identified as per<br />
standard methods 14. All urine<br />
samples were inoculated onto<br />
cysteine lactose electrolyte<br />
deficient (CLED) medium using a<br />
calibrated loop (volume-0.005 ml)<br />
and were incubated for 18-24 h at<br />
37˚C. Wet mount preparations<br />
©2014 <strong>Mediterranean</strong> Center <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong>
S. Shkurti 9<br />
were also made from all urine<br />
samples to look for pus cells and<br />
epithelial cells. Depending upon<br />
the number <strong>of</strong> the colonies grown<br />
on the CLED medium, the<br />
interpretations <strong>of</strong> urine culture<br />
were made as insignificant (50 -
<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 7-12 10<br />
males) had positive culture result<br />
and there was a statistically<br />
significant relation between<br />
gender and UTI (p=0.005).<br />
Wet mount microscopy for<br />
presence <strong>of</strong> bacteria or pus cells in<br />
significant amount per field had<br />
sensitivity, specificity, positive<br />
predictive value (PPV) and<br />
negative predictive value (NPV)<br />
<strong>of</strong> 83, 58, 44 and 89 per cent,<br />
respectively in detecting<br />
infections.<br />
Of the 2876 culture positives, E.<br />
coli was the most common (59%)<br />
isolate. (Table I).<br />
4. Discussion<br />
Cipr<strong>of</strong>loxacin and <strong>of</strong>loxacin are<br />
the most extensively used<br />
fluoroquinolones for the<br />
treatment <strong>of</strong> UTIs. This study<br />
showed that E. coli was the<br />
commonest pathogen causing<br />
complicated and uncomplicated<br />
UTI as described previously[1]<br />
[3]. There are several organisms<br />
known to cause UTIs, including<br />
P. aeruginosa, S. saprophyticus,<br />
S.epidermidis, Enterococcus spp,<br />
P. mirabilis, Klebsiella spp.,<br />
Citrobacter spp, etc. as reported by<br />
earlier workers[4]. This study also<br />
demonstrates the emergence <strong>of</strong> E.<br />
faecalis and the non-fermenters<br />
Acinetobacter spp and Pseudomonas<br />
spp as major uropathogens<br />
especially in the patients admitted<br />
in the hospitals, more so in the<br />
intensive care units. Such findings<br />
have been documented<br />
elsewhere[5-16]. The percentage <strong>of</strong><br />
isolates <strong>of</strong> E.coli resistant to<br />
ampicillin was found to be as<br />
much as 80 per cent in our set up.<br />
Such high levels <strong>of</strong> resistance to<br />
ampicillin have been quoted by<br />
many other studies from different<br />
parts <strong>of</strong> Albania[5]. Our MIC<br />
results showed that<br />
fluoroquinolone resistance<br />
increased significantly with<br />
patient’s age. An MIC <strong>of</strong> 256<br />
μg/ml was noted in the age group<br />
<strong>of</strong> >60 yr <strong>of</strong> age. There could be<br />
two explanations for this. Firstly,<br />
as a consequence <strong>of</strong> frequent<br />
exposure to fluoroquinolones<br />
resulting from the treatment <strong>of</strong><br />
repeated infections in elderly<br />
leads to increase in MIC <strong>of</strong><br />
fluoroquinolone19. Secondly,<br />
unlike urinary tract infections<br />
(UTIs) in females, UTIs in males<br />
are frequently complicated and are<br />
more likely to require prolonged<br />
antimicrobial therapy, especially<br />
in the elderly, potentially<br />
explaining the fluoroquinolone<br />
the higher MIC[25].<br />
©2014 <strong>Mediterranean</strong> Center <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong>
S. Shkurti 11<br />
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DP, Ritchie DJ, Blackner LK,<br />
Coyle EA, et al. Relationship<br />
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7. Arslan H, Azap OK, Ergönül<br />
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in Turkey. J Antimicrob<br />
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8. Karlowsky JA, Kelly LJ, Thornsberry<br />
C,Jones ME, Sahm DF. Trends<br />
in antimicrobial resistance<br />
among urinary tract<br />
9. Kahlmeter G. An international survey<br />
<strong>of</strong> 8. the antimicrobial<br />
susceptibility <strong>of</strong> pathogens from<br />
uncomplicated urinary tract<br />
infections: the ECO·SENS<br />
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2003; 51 : 69-76.<br />
10. Anjum F, Kadri SM, Ahmad I,<br />
Ahmad S. A study <strong>of</strong> recurrent<br />
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Srinagar, Kashmir, India. JK -<br />
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11. Kauser Y, Chunchanur SK, Nadagir<br />
SD, Halesh LH,<br />
Chandrashekhar MR. Virulence<br />
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urinary tract infections. AJMS<br />
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12. Pais P, Khurana R, George J. Urinary<br />
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13. Ena J, Amador C, Martinez C, Ortiz<br />
de la Tabla V. Risk factors for<br />
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cipr<strong>of</strong>loxacin-resistant<br />
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22. Arjunan M, Al-Salamah AA,<br />
Amuthan M. Prevalence and<br />
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23. Bhargavi PS, Gopala Rao TV,<br />
Mukkanti K, Dinesh Kumar B,<br />
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24. Gupta N, Kundra S, Sharma A,<br />
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V, Shetty K. Changing trends in<br />
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25. Hummers-Pradier E, Koc M, Ohse<br />
AM, Heizman WR, Kochen<br />
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Infect Dis 2005; 37 : 256-61.<br />
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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> Volume 1, Issue 1, October 2014: 13-20<br />
Original Paper<br />
Factors affecting the introduction <strong>of</strong> ICTs for<br />
‘healthcare decision-making’ in hospitals <strong>of</strong><br />
developing countries<br />
Najam Afaq Qureshi 1 ,Qamar Afaq Qureshi 2 , Dr. Muhammad Zubair<br />
Khan 2 , Dr. Bahadar Shah 3 , Irfan Marwart 2<br />
1 Sarhad University, Pakistan, 2 Gomal University, Pakistan, 3 Hazara University, Pakistan<br />
Abstract<br />
Background & objectives: Several studies have evaluated the impacts <strong>of</strong> ICTs on decisionmaking<br />
process in both public and private health organizations but there is a dearth <strong>of</strong> such<br />
studies that integrate ICTs and effective decision making in Pakistan. Since the Pakistani<br />
governments continue to provide huge IT investment for its designated e-government<br />
agencies, the need to comprehend the impacts <strong>of</strong> ICTs on effective decision making becomes<br />
more important.<br />
Methods: This study strives to ameliorate the comprehension <strong>of</strong> the impacts <strong>of</strong> ICTs for<br />
decision-making process at all management levels <strong>of</strong> both public and private health<br />
organizations in Pakistan. Research on the information and communication technologies for<br />
decision-making is tabling new tools and techniques in the marketplace.<br />
Results: This study attempts to unearth literature review-based definition <strong>of</strong> the local<br />
decision-situations to help private and public sector organizations in Pakistan.<br />
Interpretation & conclusion: In the emerging ICTs environment, IT elements such as e-mail<br />
and group support facilities improve the coordination among the members <strong>of</strong> an organization<br />
in decision making. The use <strong>of</strong> these ICTs improves the organizational communication, which<br />
ultimately leads to effective decision-making<br />
Key words: ICTs; adoption factors; decision-making; healthcare; developing countries.<br />
1. Introduction<br />
The concept <strong>of</strong> ‘global-village’<br />
indicates high levels <strong>of</strong> interaction<br />
between nations <strong>of</strong> the world. It<br />
also reflects impacts <strong>of</strong><br />
globalization with global culture<br />
on the organizational life <strong>of</strong> public<br />
and private organizations working<br />
in both developed and developing<br />
societies (Luthans, 2002: 47).<br />
Modern organizational life is<br />
characterized with complex<br />
environments demanding the<br />
processing <strong>of</strong> huge data to analyze<br />
and diagnose complex situations<br />
(Robbins, 1998:6). It is the “fastpaced,<br />
global, highly competitive<br />
and information-intensive<br />
environment, due to which<br />
managers are facing new decision-
<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 13-20 14<br />
making challenges (Boiney,<br />
2000:33).<br />
Despite these environmental<br />
pressures, the decision-making is<br />
unanimously considered as the<br />
most important and unique<br />
function <strong>of</strong> every manager<br />
(Drucker, 1974:465; Loomba,<br />
1978:3). In this modern age<br />
traditional decision-making<br />
approach has been replaced by a<br />
systematic decision making<br />
process (Weihrich and Koontz,<br />
1999:199), which is a key factor<br />
driving the quest for information<br />
and development <strong>of</strong> supporting<br />
technologies (Boiney, 2000:32;<br />
Turban et al., 2004:544). Digital<br />
technology has influenced all<br />
sectors like business, government<br />
utility services and personal life.<br />
1.1 ICTs in health sector<br />
One <strong>of</strong> the most significant<br />
impacts <strong>of</strong> the ongoing<br />
information revolution has been<br />
on the health sector. In the field <strong>of</strong><br />
health care, ICTs have emerged as<br />
key instruments in solving many<br />
<strong>of</strong> the most pressing problems.<br />
ICT has helped to bridge the gap<br />
between the provider and seeker<br />
through telemedicine and remote<br />
consultations, enabled health<br />
knowledge management by<br />
institutions and agencies, and<br />
facilitated in the creation <strong>of</strong><br />
networks between providers for<br />
exchange <strong>of</strong> information and<br />
experiences. In fact, globally, the<br />
e-Health or health telematics<br />
sector is fast emerging as the third<br />
industrial pillar <strong>of</strong> the health<br />
sector after the pharmaceutical<br />
and the medical (imaging) devices<br />
industries(Macleod,2007).From a<br />
development perspective, ICTs<br />
are key instruments towards<br />
meeting the Millennium<br />
Development Goals (MDGs)<br />
related to health. In this respect,<br />
the increasing adoption <strong>of</strong> ICT in<br />
health care services <strong>of</strong> developing<br />
countries, by both public and<br />
private sectors, has been a<br />
welcome trend. All across the<br />
world, governments are pledging<br />
and pooling more and more <strong>of</strong><br />
their resources towards<br />
developing ICT tools and systems<br />
with the ultimate aim <strong>of</strong><br />
facilitating management,<br />
streamlining surveillance and<br />
improving health care through<br />
better delivery <strong>of</strong> preventive and<br />
curative services (Turban et al.,<br />
2004). In line with this trend the<br />
government <strong>of</strong> Pakistan in August<br />
2000, announced an integrated<br />
policy <strong>of</strong> Information<br />
Technology, which has been<br />
welcomed as step towards<br />
modernization and globalization.<br />
2. Factors affecting adoption<br />
and use <strong>of</strong> ICTs in hospitals<br />
The increasing pressure <strong>of</strong><br />
business environment <strong>of</strong> the<br />
©2014 <strong>Mediterranean</strong> Center <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong>
N. A. Qureshi et al 15<br />
information age is forcing the<br />
organizations <strong>of</strong> the entire world<br />
to adopt and use Information and<br />
communication technologies<br />
(ICTs) in decision making. It is<br />
well reported that private sector<br />
organizations are using<br />
information system for achieving<br />
strategic advantages and gaining<br />
financial and business benefits<br />
more than its public counterpart.<br />
The influence <strong>of</strong> some factors on<br />
the information system (IS)<br />
success is well documented (see<br />
for example, Ahlan, 2005; Michel<br />
& Betty, 2003); Andrew Georgiou<br />
et al., 2002). Various studies have<br />
pointed out Users, executives,<br />
Proper Organization, and external<br />
environment as the key crucial<br />
factors that influence<br />
implementation <strong>of</strong> ICTs in any<br />
organization.<br />
2.1 Users<br />
Human relations movement<br />
(behavioral approach to<br />
management) stresses that human<br />
element in an organization must<br />
be given importance in order to<br />
increase the organizational<br />
efficiency (Certo, 2001:37-38). It<br />
also emphasizes that effective<br />
human relations generate<br />
commitment <strong>of</strong> workers and high<br />
productivity in organizations.<br />
Thus management must build<br />
appropriate relationships with its<br />
people, as ability to work with<br />
people enhance organizational<br />
success. A manager under<br />
interpersonal role motivates,<br />
directs people and performs duties<br />
<strong>of</strong> social nature i.e. generates<br />
respect for each other, trusts the<br />
workers. likewise the success <strong>of</strong><br />
ICTs is not possible in the<br />
organizations whereby the human<br />
element is not given importance<br />
and where exists a lack <strong>of</strong><br />
participation <strong>of</strong> end users in IS<br />
(Information<br />
system)<br />
development proceedings as<br />
asserted by Macleod (2007) that<br />
design and implementation <strong>of</strong> the<br />
hardware/s<strong>of</strong>tware have greater<br />
success rates in the organizations<br />
whereby end users and ITstaff/pr<strong>of</strong>essionals<br />
jointly develop<br />
an information system and as<br />
Bradly (2006) says that it is the<br />
human element which is related<br />
with the adoption and success <strong>of</strong><br />
new technologies.<br />
The literature reveals that private<br />
health organizations in Pakistan<br />
are more inclined to e-government<br />
initiatives and whereby the<br />
executives <strong>of</strong> these hospitals are<br />
more interested in the adoption<br />
and use <strong>of</strong> IT in their decision<br />
making process than the<br />
management <strong>of</strong> public sector<br />
hospitals. Furthermore, private<br />
health organizations are involving<br />
the doctors, physicians and other<br />
healthcare workers in information<br />
system (IS) development.<br />
Literature also highlights that to<br />
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date the private sector’s use <strong>of</strong><br />
information systems for achieving<br />
strategic advantages and gaining<br />
financial and business benefits is<br />
much greater than its public<br />
counterparts (Ahlan, 2005)”.<br />
According to Macleod et al. (2007)<br />
people have no participation in<br />
the IS development due to<br />
concept prevailing in public health<br />
organizations that their<br />
suggestions for IS development<br />
and implementations are neither<br />
welcomed nor entertained and<br />
also increases the time duration <strong>of</strong><br />
IS development. Similarly Certo<br />
(2001: 37-38) argues that<br />
organizational success can be<br />
enhanced by building appropriate<br />
relationships with the people.<br />
2.2 Executives<br />
Literature reveals that in private<br />
organizations management<br />
arranges and provides proper<br />
training to the people, the<br />
environment is friendlier,<br />
management has trust in their<br />
employees and people have<br />
respect for each other.<br />
Furthermore, results <strong>of</strong> the<br />
different studies validate the<br />
assertion that human force in<br />
private health organizations is<br />
highly qualified, pr<strong>of</strong>essional,<br />
trained and well experienced as<br />
well as more committed to the<br />
adoption and use <strong>of</strong> IT in decision<br />
making process than the<br />
managerial staff <strong>of</strong> public health<br />
organization ( see for example,<br />
Keri, 2007; Michel & Betty,2003);<br />
Avital, 2003).<br />
Executives are responsible for<br />
overall management <strong>of</strong> the<br />
organization. They establish<br />
operating policies and guide the<br />
organization’s interaction with its<br />
environment (Stoner and<br />
Wankle, 1986:15) and play<br />
different roles such as<br />
interpersonal, informational and<br />
decisional. Thus under<br />
information role they are<br />
responsible for transmitting the<br />
information received from outside<br />
or from other subordinates to the<br />
members <strong>of</strong> the organization and<br />
transmits information to outsiders<br />
on organization’s plans, policies,<br />
actions and results (Robins and<br />
Decenzo, 2006: 37). To play an<br />
informational role successfully,<br />
executives require and make the<br />
use <strong>of</strong> ICTs but our study reveals<br />
that executives <strong>of</strong> public<br />
organizations do not take interest<br />
in the adoption and use <strong>of</strong> ICTs as<br />
pinpointed by Ahlan (2005) that<br />
the executives in public health<br />
organizations do not take much<br />
interest in the adoption and use <strong>of</strong><br />
ICTs, they do not possess<br />
awareness about ICTs and have<br />
no experience <strong>of</strong> using the same<br />
for solving their unstructured<br />
problems.<br />
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N. A. Qureshi et al 17<br />
2.3 Proper Organization<br />
Proper organization helps the<br />
smooth running <strong>of</strong><br />
administration. It provides an<br />
opportunity to direct employees<br />
and coordinate their efforts. It<br />
facilitates the distribution <strong>of</strong> work<br />
among different units. It provides<br />
channels <strong>of</strong> communication,<br />
command and coordination. It<br />
fixes authority and<br />
responsibilities for each individual<br />
<strong>of</strong> an organization. All this<br />
indicates that organization has<br />
many roles to play in<br />
administrative processes. Despite<br />
all such theoretical claims<br />
literature study reveals that there<br />
is poor organization mechanism<br />
in the public health organizations,<br />
however, reasons to which are<br />
multifarious and playing different<br />
roles such as highly centralized<br />
system, limited participation,<br />
unclear role and responsibilities,<br />
lack <strong>of</strong> cooperation and<br />
coordination, absence <strong>of</strong> time<br />
work, lack <strong>of</strong> interest and<br />
commitment. This highly<br />
centralized system <strong>of</strong><br />
administration with nonparticipatory<br />
approach <strong>of</strong> the<br />
public sector organizations is the<br />
main obstacle in the ICTs success<br />
(Hage & Aiken, 1969).<br />
2.4 External environment<br />
The environment <strong>of</strong> an<br />
organization contains both<br />
supportive and antagonistic<br />
forces. An organization system<br />
derives support from clients or<br />
customers who need its products<br />
and services and from society’s<br />
protection <strong>of</strong> property and other<br />
rights. But the organization is also<br />
subject to the constraints <strong>of</strong> public<br />
regulations, demands for social<br />
responsibility, and meeting<br />
multiplicity <strong>of</strong> demand that are<br />
<strong>of</strong>ten conflicting (McFarland,<br />
1979: 290). It is part <strong>of</strong> every<br />
manager’s responsibility to be<br />
alert about the forces <strong>of</strong> external<br />
environment that affect an<br />
organization and its goal.<br />
However, findings <strong>of</strong> the study<br />
indicate that the management <strong>of</strong><br />
private health organization is<br />
more capable to fight with both<br />
external and internal environment<br />
to meet their desired objectives<br />
than to its counterparts.<br />
3. Discussions<br />
ICTs refer to how an organization<br />
transfers its inputs into outputs.<br />
Every organization has<br />
information technology that<br />
converts financial, human and<br />
physical resources into products<br />
or services ( Robbins,1998). But<br />
ICTs in private health<br />
organizations are fully compatible<br />
with the organizational systems<br />
because they are designed,<br />
developed and implemented<br />
according to an existing work<br />
patterns and requirements <strong>of</strong> an<br />
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organization Hughes (2003).<br />
Similarly, Macleod (2007) argues<br />
that design and implementation <strong>of</strong><br />
the information technology have<br />
greater success rates in the private<br />
organizations because <strong>of</strong> user’s<br />
participation in information<br />
system development process. The<br />
literature reveals that information<br />
technology is making the greatest<br />
impact on the nature <strong>of</strong><br />
management thereby forcing the<br />
managers to adapt themselves<br />
with the emerging new trends<br />
(Haiman et al., 1985:37). Similarly,<br />
Boiney (2000:32) and Turban, et<br />
al. (2004:549) argues that the need<br />
to speed up, coordinate and<br />
improve the aspects <strong>of</strong> decisionmaking<br />
has led managers to adopt<br />
enabling technologies. In the<br />
emerging ICTs environment, IT<br />
elements such as e-mail and group<br />
support facilities improve the<br />
coordination among the members<br />
<strong>of</strong> an organization in decision<br />
making. The use <strong>of</strong> these ICTs<br />
improves the organizational<br />
communication, which ultimately<br />
leads to effective decision-making<br />
(Rockart and Short, 1989).<br />
Furthermore ICTs are very useful<br />
means for collection and<br />
dissemination <strong>of</strong> information that<br />
is why most <strong>of</strong> the executives and<br />
the managers <strong>of</strong> private health<br />
organizations use e-mails<br />
frequently because they believe<br />
that ICTs can convey things more<br />
effectively Keri (2007).<br />
4. Conclusion<br />
Quick access to relevant and valid<br />
information is possible through<br />
information and communication<br />
technologies. Furthermore these<br />
new technologies provide<br />
information that is needed for<br />
better decision-making on the<br />
issues affecting an organization<br />
regarding human and material<br />
resources. Majority <strong>of</strong> the<br />
managers try to be rational while<br />
making decisions but to do so they<br />
must follow the steps <strong>of</strong> rational<br />
making process i.e. defining the<br />
problem situation, develop the<br />
alternatives, evaluate the<br />
alternatives and select the best one<br />
available and finally<br />
implementation and monitoring<br />
<strong>of</strong> the decision. In addition the<br />
‘development <strong>of</strong> the alternatives –<br />
phase’ <strong>of</strong> decision-making process<br />
will not be effective until the<br />
availability <strong>of</strong> timely and accurate<br />
information to analyze the<br />
decision situation and generate as<br />
many alternatives as possible too<br />
stresses the importance <strong>of</strong><br />
information and developing<br />
alternatives for effective<br />
decisions.<br />
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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> Volume 1, Issue 1, October 2014: 21-30<br />
Original Paper<br />
Assessment Of Nutritionnal Status Of Hiv<br />
Infected And Hiv Negative Pregnant Women In<br />
Ngaoundere, Cameroon<br />
M Dangwe 1, 2 , C M Mb<strong>of</strong>ung 1<br />
1 Laboratory <strong>of</strong> Biophysics, food biochemistry and Nutrition<br />
2 Laboratory <strong>of</strong> Protestant hospital <strong>of</strong> Ngaoundere<br />
Background & objectives: Malnutrition (underfeeding) can affect the treatment <strong>of</strong> AIDS in<br />
that it reduces the ability <strong>of</strong> the intestine to absorb drugs, organic substances and<br />
micronutrients. Underfeeding could also increase the chances <strong>of</strong> transmission <strong>of</strong> the disease<br />
from an infected mother to the baby during pregnancy. The objective <strong>of</strong> this study is to<br />
compare the energy intake, weigh rate and nutritional status between the HIV and non HIV<br />
pregnant women attending two referrals hospitals in Ngaoundere (Cameroon).<br />
Methods:A cross sectional study using 24-hour dietary recall was applied to a sample <strong>of</strong> 109<br />
women, randomly selected from a population-based and anthropometric data were done.<br />
Results: Result show that HIV negative pregnant women consumed less energy intake per<br />
day than the HIV infected pregnant women at all age groups with no significant difference<br />
(F cal =1.19, p=0.317). Gain in weight between the HIV infected and HIV negative pregnant<br />
women in relation to their various age groups was no significant (F= 1.23, p=0.27). There was<br />
no significant influence <strong>of</strong> HIV status in pregnant women BMI (F=2 29, p=0.133).<br />
Interpretation & conclusion:In this study, the higher consumption <strong>of</strong> energy by HIV infected<br />
pregnant women than HIV negative women could be because HIV infected pregnant women<br />
were at the beginning <strong>of</strong> the infection which has not yet affected the immune system. In the<br />
two referral hospital <strong>of</strong> Ngaoundere besides HIV screening tests, should be also nutritional<br />
services to advice these women on their nutritional habits.<br />
Keywords: Malnutrition, Body mass Index, HIV/AIDS, energy consumption<br />
1. Introduction<br />
Acquired Immune Deficiency<br />
Syndrome (AIDS) is an<br />
infectious disease caused by the<br />
Human Immunodeficiency Virus<br />
(HIV) which appeared for the<br />
first time in the mid 1980 (BICE,<br />
1993). The Human<br />
Immunodeficiency Virus (HIV)<br />
reproduces in certain blood cells<br />
and more specifically in the white<br />
blood cells (WBC). The HIV<br />
thus attacks and weakens the<br />
immune system rendering the<br />
victim vulnerable to infections. It
<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 21-30 22<br />
has ravaged sub-Sahara Africa for<br />
decades and is still a major cause<br />
<strong>of</strong> adult morbidity and mortality<br />
(Masanjala, 2007). Recent<br />
estimates by the World Health<br />
Organization (WHO) show that<br />
about 33.3 million people are living<br />
with HIV/AIDS worldwide with<br />
22.5 million living in sub-Saharan<br />
Africa (Global Report, 2010). The<br />
prevalence in Cameroon stands at<br />
5.5 % with the Adamawa region<br />
occupying the 5 th position with 6.9<br />
% (Comité National de Lutte<br />
contre le Sida, 2004).<br />
Studies outlined that there<br />
is a relationship between<br />
malnutrition and AIDS (AIDS<br />
institute, 1995). Research shows<br />
that, the chance <strong>of</strong> infection with<br />
the HIV virus might be reduced<br />
in individuals who have good<br />
nutritional status with<br />
micronutrients and especially,<br />
vitamin A playing significant<br />
roles (ACC, 1998). Malnutrition<br />
(underfeeding) can affect the<br />
treatment <strong>of</strong> AIDS in that it<br />
reduces the ability <strong>of</strong> the<br />
intestines to absorb drugs, organic<br />
substances and micronutrients.<br />
Underfeeding could also increase<br />
the chances <strong>of</strong> transmission <strong>of</strong> the<br />
disease from an infected mother<br />
to the baby during pregnancy<br />
(Semba, 1997).<br />
This affirmation thus necessitates<br />
certain questions on the<br />
increasing rate <strong>of</strong> HIV positives<br />
in this region <strong>of</strong> the world, which<br />
is one <strong>of</strong> the most affected<br />
(CNLS, 2004). One would<br />
therefore be tempted to believe<br />
that underfeeding plays an<br />
important role in increasing the<br />
damaging effects <strong>of</strong> the<br />
HIV/AIDS. In the town <strong>of</strong><br />
Ngaoundere, there is a dearth <strong>of</strong><br />
informations on the relationship<br />
between underfeeding and<br />
HIV/AIDS. Thus, this study was<br />
undertaken to compare the energy<br />
intake, weight rate and nutritional<br />
status between the HIV and non-<br />
HIV pregnant women attending<br />
two referrals hospitals in<br />
Ngaoundere, Cameroon.<br />
2. Materials And Methods<br />
Study Area<br />
Ngaoundere is the capital city <strong>of</strong><br />
the Adamawa Region, Cameroon.<br />
The city is located at latitude<br />
7 0 .19’N and longitude 13 0 34’E. Its<br />
population was estimated at<br />
about 230,000 inhabitants in 2001<br />
(Tchotsoua, 2006).The Adamaoua<br />
region is high in altitude; its<br />
whether is between 22 and 25 0 .<br />
This plateau contains 2 types <strong>of</strong><br />
climates: the Sudanese type <strong>of</strong><br />
tropical climate and the<br />
Cameroon type <strong>of</strong> equatorial<br />
climate. The Sudanese type <strong>of</strong><br />
tropical climate has a dry season<br />
covering the period <strong>of</strong> November<br />
to March; then comes the moist<br />
season with down falls ranging<br />
from 900 mm to 1500mm. The<br />
©2014 <strong>Mediterranean</strong> Center <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong>
N. A. Qureshi et al 23<br />
Cameroon type <strong>of</strong> equatorial<br />
climate has a long dry season<br />
followed by a long rainy season.<br />
The down falls here range<br />
1500mm to 2000mm per year<br />
(Okouba and al., 2010).<br />
Study population and Design<br />
The study was cross-sectional in<br />
design. Pregnant women that<br />
attended antenatal services <strong>of</strong> the<br />
two referral hospitals in<br />
Ngaoundere (Protestant and<br />
Regional) were enrolled for the<br />
study. The study was conducted<br />
from May 2003 to January 2005. A<br />
total <strong>of</strong> 109 pregnant women at<br />
their third trimester were<br />
randomly selected and enrolled<br />
for the study. They were grouped<br />
into HIV infected (13) and non-<br />
HIV infected (96).<br />
Four age groups were ranged for<br />
the evaluation <strong>of</strong> age influence as<br />
a factor studied ( 27 years).<br />
Questionnaire Administration<br />
Questionnaires were administered<br />
to the women to collect data on:<br />
Age, level <strong>of</strong> education, number <strong>of</strong><br />
children, gravidity, preferred<br />
meals, family inherited illnesses,<br />
certain disease frequency in the<br />
family and pre-natal treatments.<br />
Nutritional feeding habits were<br />
obtained through interviews on<br />
the diets. A 24-hour dietary recall<br />
was applied to a sample <strong>of</strong><br />
women, randomly selected from a<br />
random population-based study<br />
sample. Most <strong>of</strong> the women had<br />
common feeding habits and their<br />
common meals were reported to<br />
be cereals (maize), tubers<br />
(cassava) and vegetables. The<br />
conversion <strong>of</strong> quantity consumed<br />
into calories was done with the<br />
help <strong>of</strong> a chart on food and<br />
nutritive value (FAO, 1968;<br />
Yadang, 2000).<br />
Assessment <strong>of</strong> nutritional status<br />
<strong>of</strong> the pregnant women<br />
Anthropometry is the<br />
measurement <strong>of</strong> human body. It is<br />
a quantitative method and is<br />
highly sensitive to nutritional<br />
status (Amuta and Houmsou,<br />
2009). The anthropometric<br />
factors: Weight (Kg) and Height<br />
(m) were used to calculate the<br />
Body Mass Index (BMI) as:<br />
()<br />
BMI =<br />
( )<br />
As the aforementioned formula<br />
reflects the human body without<br />
pregnancy, we subtracted the<br />
foetal weight from the total<br />
weight <strong>of</strong> the pregnant woman to<br />
get the exact BMI.<br />
We generally assume that a body<br />
mass index less than 18.5 implies<br />
that the woman is thin and<br />
between 18.5 and 25, we say the<br />
woman has a normal weight<br />
meanwhile values superior than 25<br />
indicates over weight (Gallagher<br />
and al.,2000).<br />
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Statistical analysis<br />
Collected data were analyzed<br />
using Statgraphics 3.0. The one<br />
way ANOVA test was used to<br />
find significant difference<br />
between the means. The<br />
significance level was at p≤0.05<br />
level.<br />
3. Results<br />
Comparison <strong>of</strong> energy intake<br />
between HIV infected and HIV<br />
negative pregnant<br />
women in Ngaoundere,<br />
Cameroon<br />
The quantity <strong>of</strong> energy consumed<br />
by HIV negative pregnant women<br />
and HIV infected pregnant<br />
women is shown in Figure 1. The<br />
result shows that HIV negative<br />
pregnant women consumed less<br />
energy intake per day than the<br />
HIV infected pregnant women at<br />
all age groups with no significant<br />
difference (F cal =1.19, p=0.317).<br />
Variation in weight gain <strong>of</strong> HIV<br />
infected and HIV negative<br />
pregnant women.<br />
Studies and analysis <strong>of</strong> the weight<br />
parameter <strong>of</strong> HIV infected and<br />
HIV negative pregnant women<br />
showed that the daily weight gain<br />
by HIV negative pregnant women<br />
is 0,041 ± 0,029 kg/day , 0.042 ±<br />
0,033 kg/day; 0,054 ± 0,047 kg/day;<br />
0,057 ±0.06 kg/day for group I, II,<br />
III and IV respectively,<br />
meanwhile for HIV infected<br />
women it is 0.038 ± 0.023kg/day;<br />
0.039 ± 0.014kg/day; 0,044 ±<br />
0,012kg/day; 0,017 ± 0.037 kg/day<br />
for group I, II, III and IV<br />
respectively (Figure 2). No<br />
significance difference was<br />
observed in weight gain between<br />
the HIV infected and HIV<br />
negative pregnant women in<br />
relation to their various age<br />
groups (F= 1.23, p=0.27).<br />
Body Mass Index (BMI) <strong>of</strong> HIV<br />
infected and HIV negative<br />
pregnant women<br />
The body mass index <strong>of</strong> HIV<br />
infected and HIV negative<br />
pregnant women is shown in<br />
Figure 3. It is observed that HIV<br />
status does not influence pregnant<br />
women BMI (F=2 29, p=0.133).<br />
Pregnant women were grouped<br />
into 3 depending on their Body<br />
Mass Index (Table 1). Results<br />
showed that 0,92% <strong>of</strong> the HIV<br />
infected pregnant women are<br />
underweight , 7,34% are <strong>of</strong><br />
normal size, and 3,67% are<br />
overweight, while 0.92% <strong>of</strong> the<br />
negative were <strong>of</strong> underweight<br />
46,79%are <strong>of</strong> normal size, and<br />
40,36% are overweight. Although<br />
according to the body mass index<br />
<strong>of</strong> women at the start <strong>of</strong><br />
pregnancy, 18.34% are thin and<br />
81.65% normal.<br />
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N. A. Qureshi et al 25<br />
Table 1: Percentages on the Body Mass Index <strong>of</strong> HIV infected and HIV negative pregnant<br />
women in relation to their age group.<br />
Number<br />
BMI (Kg/m 2 ) HIV positive (%) HIV Negative (%)<br />
Underweight (< 18.5) 1 (0,92) 1 (0,92)<br />
Normal weight (18.5-25) 8 (7,34) 51 (46,79)<br />
Overweight (˃ 25) 4 (3,67) 44 (40,36)<br />
4000<br />
3500<br />
3000<br />
2500<br />
Energy (Kcal/J)<br />
2000<br />
1500<br />
1000<br />
500<br />
HIV negative pregnant women<br />
HIV infected pregnant women<br />
0<br />
< 19 19-22 23-26 27-35<br />
(Years)<br />
Fig1: Comparison <strong>of</strong> energy intake between HIV infected and HIV negative<br />
pregnant women in relation to age.<br />
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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 21-30 26<br />
120<br />
100<br />
HIV negative pregnant women<br />
HIV infected pregnant women<br />
80<br />
weight *10 -3 (kg)<br />
60<br />
40<br />
20<br />
0<br />
N. A. Qureshi et al 27<br />
4. Discussion<br />
Generally, the energy intake by<br />
HIV infected pregnant women<br />
appears to be higher than that <strong>of</strong><br />
HIV negative pregnant women.<br />
This could be because HIV<br />
infected pregnant women were at<br />
the beginning <strong>of</strong> the infection<br />
which has not yet affected the<br />
immune system. It could be also<br />
due to the fact that there were not<br />
aware <strong>of</strong> their HIV status which<br />
could have affected their mind<br />
therefore influencing them to lose<br />
weight through their thoughts. A<br />
study reported that the quantity<br />
<strong>of</strong> energy necessary for pregnant<br />
women <strong>of</strong> the third trimester is<br />
2,250 kcal per day. However, a<br />
comparison <strong>of</strong> the energy taken by<br />
the HIV negative and HIV<br />
infected pregnant women in this<br />
study revealed that the energy<br />
levels were higher than values<br />
reported by Dupin and al<br />
(1992).This could be justified by<br />
the fact that these pregnant<br />
women were in the third trimester<br />
<strong>of</strong> pregnancy when they have the<br />
tendency <strong>of</strong> eating a lot<br />
irrespective <strong>of</strong> their HIV status.<br />
In our study group, we noticed<br />
that infected pregnant women and<br />
non infected pregnant women<br />
gain weight during pregnancy.<br />
We observe that the biggest mean<br />
rates <strong>of</strong> gain for 3 rd trimester <strong>of</strong><br />
pregnancy in our population<br />
group is 0,399kg/wk for HIV<br />
negative pregnant women and<br />
0,308 kg/wk for HIV infected<br />
pregnant women. The presumably<br />
gain weight from HIV-uninfected<br />
adult women from the United<br />
States and Europe are 0,30 to 0,54<br />
kg/wk during the 3 rd trimester.<br />
However, people on whom we<br />
worked have weight ranges these<br />
values. This result is similar to<br />
those reported by Strauss and al.<br />
(1999) and Ladner and al (1998),<br />
but contrasts that <strong>of</strong> Kim and al.<br />
(1996) who observed HIV<br />
infected subjects to be suffering<br />
from underfeeding and weight<br />
lost at the onset <strong>of</strong> the infection.<br />
The difference between our study<br />
and that observed by Kim et al.<br />
(1996) is that the subjects enrolled<br />
in our study were found to have<br />
more energy intake than the<br />
recommended<br />
energy<br />
consumption. The energy surplus<br />
consumed by these pregnant<br />
women would have compensated<br />
the expected weight. We did not<br />
find further evidence in the<br />
literature that suggested<br />
differences in the pattern <strong>of</strong><br />
weight gain by HIV status. But<br />
we know that lean body mass loss<br />
can be improved when nutrition<br />
counseling is combined with<br />
nutritional interventions (Stack<br />
and al.,1996). The body mass index<br />
observed in our study show that<br />
HIV status does not influence the<br />
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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 21-30 22<br />
weight gain by pregnant women.<br />
This result is similar with studies<br />
reported in Tanzania who find<br />
that there is not significant<br />
difference between body mass<br />
index infected and HIV-negative<br />
women (Villamor and al., 2004).<br />
This could be justified by the fact<br />
that these infected women are at<br />
the beginning <strong>of</strong> their illness.<br />
5. Conclusion<br />
Our study report that, no<br />
significant difference was<br />
observed between HIV infected<br />
and HIV negative pregnant<br />
women with regards to energy<br />
intake and weight gain. Our<br />
results also showed that age<br />
groups and HIV status had no<br />
significant influence on the<br />
pregnant women’s Body Mass<br />
Index. Besides HIV screenings<br />
test, were done to the women<br />
attending their antenatal services<br />
in there should be also nutritional<br />
services to advice these women on<br />
their nutritional habits.<br />
Acknowledgements<br />
The authors thank the<br />
pregnant women that attended the<br />
regional and protestant hospitals<br />
<strong>of</strong> the Adamaoua region for their<br />
kindness and collaboration which<br />
allowed successful data collection.<br />
The nurses <strong>of</strong> antenatal services<br />
both hospitals are also<br />
acknowledged.<br />
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Karita, E., De Clercq, A., Van de<br />
Perre, P. & Dabis, F. (1998).<br />
Pregnancy, body weight and human<br />
immunodeficiency virus infection in<br />
African women: a prospective<br />
cohort study in Kigali (Rwanda),<br />
1992–1994. Int. J. Epidemiol.<br />
27:1072-1077.<br />
12. Masanjala, W., 2007. The poverty-<br />
HIV/AIDS nexus in Africa: A<br />
livelihood approach. Social Science<br />
et Medicine, 64 (5): 1032-1041.<br />
13. Okouba Barnabe ; Ambroise Abanda ;<br />
Tchomthe séverin ., 2010. Rapport<br />
Régional des Progrès des objectifs<br />
du millénaire pour le<br />
développement. Région de<br />
l’Adamaoua. Sous la coordination<br />
de l’Institut National de la<br />
statistique du Cameroun avec<br />
l’appui du PNUD. Ministère de<br />
l’Economie de la Planification et de<br />
l’Aménagement du Territoire.<br />
14. Semba R D., 1997.Overview <strong>of</strong> the<br />
potential role <strong>of</strong> vitamin A in<br />
mother-to child transmission <strong>of</strong><br />
HIV-1. Acta paediatr suppl<br />
421:107-112.<br />
15. Sibetcheu, D; Nanka, P. M; Tatat , J;<br />
Ngoh,G. M.M; Hakoua, A.,<br />
2000. Enquêtes Nationales sur la<br />
carence en vitamines A et<br />
l’anémie au Cameroun.<br />
16. Statgraphics plus 3.0 (1994).<br />
Statgraphics for windows<br />
version release 3.0.<br />
17. Strauss, R. S. & Dietz, W. H. (1999).<br />
Low maternal weight gain in the<br />
second or third trimester<br />
increases the risk for<br />
intrauterine growth retardation.<br />
J. Nutr. 129:988-993.<br />
18. Tchotsoua (2006). Evolution<br />
récente des territoires de<br />
l’Adamawa central: de la<br />
spatialisation à l’aide pour un<br />
développement maîtrisé.<br />
Université d’Orléans. Ecole<br />
doctorale sciences de l’homme<br />
et de la société. HDR.<br />
Discipline (Géographie<br />
Aménagement-Environnement).<br />
p 267.<br />
19. Villamor Eduardo; Michele L.<br />
Dreyfuss; Ana Baylín * ; Gernard<br />
Msamanga; Wafaie W. Fawzi *<br />
(2004). Weight loss during<br />
pregnancy is associated with<br />
adverse pregnancy outcomes<br />
among HIV-1 infected women<br />
The American Society for<br />
Nutritional <strong>Sciences</strong>.<br />
20. Yadang, 2000. Etude de la valeur<br />
nutritive de quelques mets de<br />
l’Extrême-Nord Cameroun.<br />
Mémoire soutenue en vu de<br />
l’obtention de la Maitrise en<br />
Biologie<br />
Appliquée.<br />
Département des sciences<br />
Biologiques. Université de<br />
Ngaoundere.<br />
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©2014 <strong>Mediterranean</strong> Center <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong>
<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> Volume 1, Issue 1, October 2014: 31-52<br />
Original Paper<br />
Issues and Prospects <strong>of</strong> e-health in Pakistan<br />
Qamar Afaq Qureshi 1 , Najam Afaq Qureshi 2 , , Dr. Muhammad Zubair<br />
Khan 2 , Dr. Allah Nawaz 1 Dr. Bahadar Shah 3 ,<br />
1 Gomal University, Pakistan 2 Sarhad University, Pakistan, , 3 Hazara University, Pakistan<br />
Abstract<br />
Background & objectives: In connection with access to information in developing countries,<br />
information flows through existing networks <strong>of</strong> communication is a main theme in the current<br />
IS literature .<br />
Methods:Information-intensive infrastructure is a requirement for information dissemination<br />
due to the shortage <strong>of</strong> network infrastructure in the majority <strong>of</strong> developing states. It is<br />
verified by many researchers that information managing technologies with their main purpose<br />
<strong>of</strong> ‘handling information’ have the advantage to enhance already existing technologies by<br />
making better information-communication a priori to new ICT innovations .Presently health<br />
information system infrastructure is deficient in resources to meet the demands and needs <strong>of</strong><br />
increasing population in developing countries. Health care systems <strong>of</strong> developing countries<br />
have major barriers like poverty and lack <strong>of</strong> technological sophistication.<br />
Results:The basic difficulties or barriers in using information technologies include poor or<br />
inadequate infrastructure, insufficient access to the hardware and inadequate or poor<br />
resources allocation. By eliminating these barriers population health status can be improved in<br />
developing countries.<br />
Interpretation & conclusion: This study aims to determine the main issues and prospects for e-<br />
health in the current situation <strong>of</strong> developing countries like Pakistan and the way forward for<br />
policy makers to manage all issues in future for more effective and rational decision-making<br />
in healthcare organizations.<br />
Key words: e-health; challenges; prospects; developing countries; Pakistan<br />
1. Introduction<br />
E–health is a latest platform for<br />
handling many healthcare issues.<br />
E-health systems have presented<br />
so many gadgets which are being<br />
used by both developed and<br />
developing states. Healthcare<br />
related IS and hardware is now<br />
inexpensively obtainable all over<br />
the world. On the other hand<br />
successful adoption and use <strong>of</strong> e-<br />
health systems depends on the<br />
suitable infrastructure (Khoja et<br />
al., 2012). The readiness and<br />
awareness <strong>of</strong> doctors and<br />
physicians about the usage <strong>of</strong> ITapplications<br />
in hospitals can be
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developed and maintained by<br />
providing proper tools and devices<br />
and proper training on regular<br />
intervals for more rapid access to<br />
information on internet. For<br />
handling users- related issues and<br />
maintaining regular use <strong>of</strong> ICTs<br />
in health organizations, healthcare<br />
providers must be given<br />
opportunity to take part in<br />
information systems development<br />
process and include the IScontents<br />
according to their<br />
requirements (Rezai-Rad et al.,<br />
2012).<br />
Concentrating on informationcentered<br />
ICT applications in<br />
developing countries is<br />
comparatively a new sphere and<br />
subject in the domain <strong>of</strong> health<br />
informatics (Kimaro & Titlestad,<br />
2008). Sound evidence-based<br />
literature extracted on influence<br />
assessments or outcome<br />
measurements is still lacking<br />
regarding ICTs-applications in<br />
the healthcare sector (Rezai-Rad<br />
et al., 2012). Published evidences<br />
are presently available on this<br />
topic and are at pilot or the pro<strong>of</strong><strong>of</strong>-concept<br />
stage. In many cases,<br />
the statements are not individual<br />
analyses, rather are based on<br />
collective skills and practices,<br />
consensus statements, and policies<br />
(Soar et al., 2012).<br />
The significance <strong>of</strong> the concepts<br />
<strong>of</strong> ‘information’, ‘information<br />
first’ has been advocated by many<br />
IS researchers for the successful<br />
adoption and use <strong>of</strong> the ITapplications<br />
in any organization<br />
and involvement towards the<br />
‘information-centered ICT’<br />
concept is a major example<br />
(Nyella & Mndeme, 2010).<br />
Furthermore the ICT-applications<br />
may only bring small direct<br />
benefits for poverty alleviation<br />
and the possibility for ICTapplications<br />
depends on both<br />
financial and access to cultural,<br />
political and educational<br />
resources. And finally, the access<br />
to social assets and increasing<br />
confidence and support through<br />
locally contextualized social<br />
networks built through<br />
community-based initiatives is<br />
more crucial than looking for<br />
access to new information from<br />
digital ICTs (Khoja et al.,2012).<br />
Many studies reveal that doctors<br />
and physicians in developing<br />
countries are not given an<br />
opportunity to be take part in<br />
information system development<br />
process, consequently IS/ICTs do<br />
not possess the features which are<br />
according to the needs <strong>of</strong><br />
healthcare providers (Rezai-Rad et<br />
al., 2012).Although e-health<br />
systems in developing countries is<br />
not a new concept any longer but<br />
there is sluggish usage <strong>of</strong> internet<br />
among healthcare providers due to<br />
lack <strong>of</strong> the capability to read, be<br />
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Q. A. Qureshi et al. 33<br />
aware <strong>of</strong> and use a variety <strong>of</strong><br />
technical terms on<br />
internet(Hogan<br />
&<br />
Palmer,2005).Furthermore the<br />
little use <strong>of</strong> internet among<br />
healthcare pr<strong>of</strong>essionals <strong>of</strong><br />
developing nations like Pakistan<br />
is mostly because <strong>of</strong> improper<br />
tools and devices and shortage <strong>of</strong><br />
proper training programs<br />
regarding eHealth systems(Malik<br />
et al., 2008).<br />
Doctors and physicians in<br />
developing countries complaint<br />
that IS and particularly the<br />
interfaces are not user friendly. In<br />
addition IT- applications in<br />
healthcare sector are inflexible in<br />
nature consequently create users’<br />
related problems .The s<strong>of</strong>tware in<br />
the hospitals <strong>of</strong> developing<br />
countries do not have the contents<br />
in native languages regarding e-<br />
health systems (Chetley,2006). E-<br />
health projects in developing<br />
countries generally unsuccessful<br />
due to a shortage <strong>of</strong> ITpr<strong>of</strong>essionals<br />
and their knowledge<br />
and expertise in e-health systems<br />
(Kimaro & Nhampossa, 2005). ITpr<strong>of</strong>essionals<br />
require training and<br />
education in order to effectively<br />
use all e-health applications<br />
.Training should be a frequent<br />
feature and healthcare<br />
pr<strong>of</strong>essional must be given the<br />
training at least once a year (Qazi<br />
& Ali, 2009).<br />
2. e-Health in Pakistan<br />
In all bad surroundings and<br />
situations, Pakistan is making its<br />
efforts for the war on terror and<br />
people <strong>of</strong> the country are facing<br />
many challenges and even die in<br />
this war in bomb blasts.<br />
Healthcare system is a<br />
requirement for developing<br />
countries like Pakistan. At<br />
present, in Pakistan near about<br />
seventy five percent <strong>of</strong> population<br />
resides in rural areas where road<br />
and transport facilities are<br />
inadequate, shortage <strong>of</strong> healthcare<br />
providers in rural areas,<br />
pr<strong>of</strong>essional physicians and<br />
surgeons are least interested to go<br />
in far flung areas because <strong>of</strong> poor<br />
infrastructure, patients being<br />
carried on their own way to arrive<br />
at the city hospital for an instant<br />
healthcare or diagnoses which<br />
could have without difficulty been<br />
treated at their own locations<br />
provided medical consultations<br />
are available (Saleem, 2010). The<br />
majority <strong>of</strong> cities in Pakistan<br />
facilitate telecommunications<br />
links, more than 1800 cities <strong>of</strong><br />
Pakistan have access to 531,787<br />
broadband connections and 400<br />
cities are on Fiber Optic, giving<br />
possibility to access universal<br />
health<br />
information.<br />
Implementation <strong>of</strong> any<br />
information system at the start is<br />
not up to the mark but it will also<br />
provide solutions usually in<br />
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emergency situations (Ansari et<br />
al.,2012).<br />
There has been an explosion in<br />
knowledge and information<br />
management activity, mainly in<br />
healthcare sector over the<br />
previous few years. By and large,<br />
hospitals and medical schools<br />
have started using the services <strong>of</strong><br />
doctors who possess computer and<br />
computerization skills. These<br />
organizations have also obtained<br />
complicated information systems<br />
to collect and retrieve<br />
accumulated knowledge. Ehealth<br />
system includes many elements<br />
such as telemedicine, teleeducation,<br />
telematics for better<br />
management <strong>of</strong> healthcare and<br />
research (Kijsanayotin ,<br />
Kasitipradith & Pannarunothai<br />
,2010). There are four areas where<br />
health informatics is performing<br />
an escalating role in healthcare<br />
development: a) administrative,<br />
b) education and training, c)<br />
quality improvement and d) the<br />
recovery <strong>of</strong> efficiency <strong>of</strong> health<br />
care services (Bhutto et al., 2010).<br />
In Pakistan 72% <strong>of</strong> population<br />
lives in rural areas and 28% <strong>of</strong><br />
population lives in urban areas.<br />
Condition <strong>of</strong> health can be<br />
determined effortlessly from the<br />
reality that there are 74 physicians<br />
per 100,000 persons in early 2000s.<br />
There are several rural areas<br />
where people have not seen a<br />
capable and skilled health<br />
pr<strong>of</strong>essional in their entire life<br />
(Bhutto et al., 2010). The<br />
municipal areas <strong>of</strong> Sindh are well<br />
equipped with health facilities;<br />
which are not enough for huge<br />
population but facilities are there,<br />
whereas rural Sindh does not have<br />
well equipped health facilities.<br />
Available possessions at urban<br />
areas can be shared as well as<br />
expanded to the rural areas with<br />
the help <strong>of</strong> digital connectivity.<br />
Particularly, Karachi capital city<br />
<strong>of</strong> Sindh holds very latest<br />
healthcare facilities (Durrani et<br />
al., 2012).<br />
In urgent cases where instant<br />
medical treatment is very vital,<br />
current studies reveal that before<br />
time and particular pre-hospital<br />
patient management leads to the<br />
patient’s survival. Especially in<br />
cases <strong>of</strong> serious head injuries,<br />
spinal cord or internal organs<br />
damage and pain, the way the<br />
events are treated and transported<br />
is critical for the forthcoming<br />
well-being <strong>of</strong> the patients<br />
.Bringing improvements in<br />
healthcare services and remain fit<br />
and healthy is one <strong>of</strong> the most<br />
discussed and key issues in our<br />
society. The acceptance <strong>of</strong> ITapplications<br />
in healthcare sector<br />
have very solid and successful<br />
attempt for the provision <strong>of</strong><br />
improved healthcare services<br />
(Malik et al., 2008). But constant<br />
©2014 <strong>Mediterranean</strong> Center <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong>
Q. A. Qureshi et al. 35<br />
guidelines must be developed and<br />
agreed across the board in<br />
connection with the processing <strong>of</strong><br />
health-related data, with<br />
particular explanations regarding<br />
diagnostic notes, which stress and<br />
assure its protection and<br />
confidentiality, as well as free and<br />
open access, by the patients to<br />
their own data. Furthermore the<br />
potential technical knowledge<br />
difficulties can be neutralized by<br />
making sure that the ITapplication<br />
is both technically<br />
possible and clinically suitable. In<br />
addition to that all citizens,<br />
doctors & physicians and policy<br />
makers must acknowledge and<br />
appreciate the adoption and use <strong>of</strong><br />
eHealth systems (Bhutto et al.,<br />
2010).<br />
The significance <strong>of</strong> a health<br />
information system (HMIS)<br />
cannot be neglected in a country<br />
like Pakistan because health<br />
policies and planning in any<br />
country generally depend on the<br />
accurate and well-timed<br />
information on various health<br />
issues (Ali & Horikoshi, 2002). In<br />
Pakistan, before the 1990s, a<br />
number <strong>of</strong> vertical programs with<br />
categorical disease-specific<br />
information systems ended in<br />
disorganized data transmission,<br />
which made evaluation <strong>of</strong><br />
program usefulness difficult for<br />
managers. In 1991-92, the Ministry<br />
<strong>of</strong> Health (MoH) started an<br />
assessment study <strong>of</strong> existing HIS<br />
and transformed the reporting<br />
systems into a comprehensive<br />
National HMIS through a<br />
consultative procedure (Qazi &<br />
Ali, 2004). However, there is need<br />
to develop integrated disease close<br />
watch infrastructure and technical<br />
competence in tropical countries<br />
on the reporting and scientific<br />
evidence necessities <strong>of</strong> the<br />
sanitary agreement under the<br />
WTO (Singer & deCastro, 2007).<br />
Health information is<br />
information about people’s health<br />
and what they, government, and<br />
others are doing about it. It<br />
explains the occurrence,<br />
frequency, and reasons <strong>of</strong> major<br />
diseases, as well as accessibility<br />
and efficiency <strong>of</strong> curative<br />
activities (Ali & Horikoshi, 2002;<br />
Khalid et al.,2008). Under the<br />
transfer <strong>of</strong> power initiative,<br />
Pakistan's MoH has advocated<br />
strengthening <strong>of</strong> health<br />
information systems for more<br />
informed decision-making in<br />
planning, managing, checking and<br />
control <strong>of</strong> healthcare services for<br />
improved service delivery in the<br />
districts. However, the efforts at<br />
increasing information systems<br />
have generally proved<br />
unproductive and sometimes<br />
counterproductive. Analyses <strong>of</strong><br />
the malfunctioning <strong>of</strong>ten fail to<br />
notice the perceptions <strong>of</strong><br />
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stakeholders as an important<br />
factor (Ansari et al., 2012).<br />
Given the large health<br />
infrastructure in Pakistan both<br />
public and private, supplying to a<br />
population <strong>of</strong> 137 million people,<br />
there had been a need to build up<br />
and start a national health<br />
management information system<br />
which is able to collect, process,<br />
analyze and provide criticism on<br />
all health related data including<br />
information on input, process and<br />
output indicators (Gururajan et<br />
al.,2008). The national feedback<br />
reports on the new HMIS admit a<br />
slow development in scope and<br />
reporting reliability, but also note<br />
the continued need for<br />
improvement in the quality and<br />
usage <strong>of</strong> information at various<br />
levels. A study carried out in 2000<br />
pointed out that the information<br />
produced via HMIS was unrelated<br />
and the data did not help<br />
managers to make decisions<br />
(Bhutto et al., 2010).<br />
Ministries <strong>of</strong> Health are<br />
approving Computer S<strong>of</strong>tware in<br />
order to get better health data<br />
collection, stretch, storage,<br />
analysis and distribution in their<br />
Health Information Systems<br />
(Khoja et al., 2008). Computer<br />
s<strong>of</strong>tware are obtained through<br />
various means including buying<br />
on-shelf s<strong>of</strong>tware, indenture based<br />
s<strong>of</strong>tware, and donated s<strong>of</strong>tware.<br />
Most <strong>of</strong> the S<strong>of</strong>tware acquired<br />
through these means is not<br />
distributed with their source codes<br />
in that they are proprietary<br />
s<strong>of</strong>tware. However, the data<br />
elements <strong>of</strong> Health Information<br />
Systems are changing regularly<br />
due to changing disease patterns;<br />
incoming and outdated drugs, and<br />
changing health policies (Ishtiaq<br />
et al., 2012).<br />
As s<strong>of</strong>tware requires to be redesigned<br />
from time to time to take<br />
on changing requirements arises<br />
there is a need to think about<br />
efforts on open source s<strong>of</strong>tware.<br />
With Open Source S<strong>of</strong>tware<br />
development method, the<br />
s<strong>of</strong>tware is distributed with their<br />
source code which means that a<br />
Ministry <strong>of</strong> Health can uphold its<br />
s<strong>of</strong>tware with no unique<br />
developers (Mostafa et al., 2011).<br />
The characteristics <strong>of</strong> Open<br />
Source S<strong>of</strong>tware development<br />
approaches seems to be<br />
appropriate in developing<br />
s<strong>of</strong>tware for Health Information<br />
System in that health information<br />
systems institutions has full<br />
access to their s<strong>of</strong>tware source<br />
codes and thus can bring in any<br />
changes according to their<br />
requirements instantly. In the<br />
case, the Ministry has no ICT<br />
capacity (say human resources) to<br />
be able to change the s<strong>of</strong>tware; the<br />
s<strong>of</strong>tware can be restructured by<br />
any computer expert and not<br />
©2014 <strong>Mediterranean</strong> Center <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong>
Q. A. Qureshi et al. 37<br />
necessarily the ones who have<br />
developed that s<strong>of</strong>tware (Durrani<br />
et al., 2012).<br />
3. Issues & Prospects<br />
Pakistan health services and<br />
health signs are usually poor<br />
especially in the far flung and<br />
rural areas. Out <strong>of</strong> 1000 infants<br />
76.6 persons <strong>of</strong> them die and the<br />
death rate under age 5 is 10.1 %.<br />
Malaria occurrence is 0.75 per 1000<br />
persons, whereas, TB incidence is<br />
181 persons per 100,000. The health<br />
expenses have been very low and<br />
not adequate to give good health<br />
to people. For example the<br />
development spending was Rs.<br />
14.272 billion for the year 2007-08,<br />
and the recent expenditure was.<br />
Rs. 3.791 billion. Improved health<br />
enhances the output <strong>of</strong> the labor<br />
force, strengthens their economic<br />
conditions and eventually enables<br />
them to lead a superior life. To<br />
achieve better, competent,<br />
effective and industrious<br />
workforce, governments promote<br />
the healthcare services. Moreover<br />
the present state <strong>of</strong> affairs <strong>of</strong> the<br />
human resource, a small<br />
adjustment in public sector<br />
expenses on healthcare services<br />
can have a strong influence on the<br />
workforce and thus the economic<br />
development.<br />
E-Health is slowly but surely<br />
becoming popular throughout the<br />
world. This is ordinary and the<br />
routine in the developed countries<br />
but developing nations are so far<br />
initializing to implement and use<br />
eHealth systems for better<br />
healthcare services (Sarkar, 2008).<br />
The appearance and advent <strong>of</strong><br />
IS/ICTs have opened new views<br />
for the countries to handle their<br />
problems consequently the<br />
developing countries are also<br />
making efforts to implement these<br />
tools and gadgets. On the other<br />
hand, there are several difficulties<br />
and barriers which needs to be<br />
removed away prior to taking full<br />
benefits <strong>of</strong> IT-applications for<br />
healthcare (Chanda & Shaw,<br />
2010).<br />
E-Health is the adoption and use<br />
<strong>of</strong> ICTs that includes the internet<br />
for more improved and better<br />
delivery <strong>of</strong> healthcare services<br />
(Eng, 2001). Another writer<br />
remarks that e-Health is a new<br />
and very potential subject and<br />
field <strong>of</strong> medical informatics,<br />
referring to the organization and<br />
delivery <strong>of</strong> healthcare services and<br />
information using the Internet<br />
and interrelated technologies<br />
(Pagliari et al., 2005). It is also<br />
noteworthy that the majority <strong>of</strong><br />
the studies about eHealth and its<br />
successful adoption and use have<br />
been carried-out in both developed<br />
(Eysenbach, 2001; Alvarez, 2004;<br />
Pagliari et al., 2005) and<br />
developing states (Mosse & Sahay<br />
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2003; Braa et al.2004; Chanda&<br />
Shaw, 2010).<br />
A number <strong>of</strong> aspects and features<br />
have been exposed as the crucial<br />
factors in creating or destroying<br />
the functions and tasks <strong>of</strong> e-<br />
Health system everywhere.<br />
Though, the research indicates<br />
that ‘top-management-support’<br />
and ‘government-ePolicies’ play<br />
leading role in all the matters<br />
concerning to the planning,<br />
development, adoption and use <strong>of</strong><br />
new ehealth systems along with<br />
their maintenance on continual<br />
basis(Scott et al., 2002). This<br />
becomes extremely important in<br />
case <strong>of</strong> the developing countries<br />
like Pakistan. The developing<br />
nations have extra issues <strong>of</strong><br />
‘digital-literacy’ <strong>of</strong> all the<br />
government authorities,<br />
developers <strong>of</strong> the systems and<br />
definitely the future users <strong>of</strong><br />
ehealth applications (Lang &<br />
Mertes, 2011).<br />
It is not just the willingness and<br />
acceptability <strong>of</strong> the all the<br />
expected users in an organization<br />
which controls and decides the<br />
success and failure <strong>of</strong> the e-Health<br />
initiatives rather it also contains<br />
the approach and stance <strong>of</strong><br />
government (external authority)<br />
as well as the top management <strong>of</strong><br />
the organization (internal<br />
executives) (Kimaro &<br />
Nhampossa,2007). Keeping in<br />
view the specified responsibility<br />
and function <strong>of</strong> top management,<br />
it is not unexpected that the<br />
interest and support <strong>of</strong> the<br />
executives in an organization has<br />
been one <strong>of</strong> the most generally<br />
talked-about organizational<br />
factors for the successful<br />
implementation <strong>of</strong> eHealth<br />
projects (Hussein et al., 2007).A<br />
lot <strong>of</strong> studies on the role <strong>of</strong> top<br />
management support for the<br />
success <strong>of</strong> e-health systems have<br />
been conducted (Sajjad et al., 2009;<br />
Qaisar & Khan, 2010).<br />
E-Health policy is fastened with<br />
the availability <strong>of</strong> resources along<br />
with the pr<strong>of</strong>essionalism is needed<br />
for the proper utilization <strong>of</strong> the<br />
resources, implementing plans<br />
and receiving the results. Lack <strong>of</strong><br />
pr<strong>of</strong>essional frame <strong>of</strong> mind and<br />
the attitude is apparently the<br />
bigger concern and matter for<br />
those developing states which<br />
have the resources (Scott et al.,<br />
2005).Government eHealth<br />
policies make an environment<br />
where the likelihood <strong>of</strong> using<br />
resources effectively is increased,<br />
the pr<strong>of</strong>essionals find their<br />
suitable places and exercise<br />
faithfully and the future <strong>of</strong> ITapplication<br />
in healthcare becomes<br />
clearly identifiable (Shaqrah,<br />
2010).<br />
In spite <strong>of</strong> the abilities and<br />
benefits <strong>of</strong> e-Health and<br />
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Q. A. Qureshi et al. 39<br />
Telemedicine for sustainability <strong>of</strong><br />
eHealth systems, some barriers, at<br />
different levels, are required to be<br />
overcome for health systems to<br />
take full advantage <strong>of</strong> these<br />
opportunities. These barriers are<br />
not<br />
uni-dimensional,<br />
concentrating on technical<br />
knowledge as assumed in the past,<br />
but somewhat a multidimensional<br />
concept, surrounding technical<br />
knowledge, economic feasibility,<br />
organizational support and<br />
behavior adaptation. The<br />
Telemedicine Alliance, a<br />
collaboration between the World<br />
Health Organization, the<br />
European Space Agency and the<br />
International<br />
Telecommunications Union<br />
studied e-Health and<br />
Telemedicine adoption trends<br />
through personal interviews with<br />
54 European telecommunications<br />
experts, health policy makers, and<br />
healthcare providers (Rhidian, &<br />
Hughes 2003).<br />
3.1 Specific Issues <strong>of</strong> Developing<br />
States like Pakistan<br />
These Issues <strong>of</strong> Developing States<br />
are divided into following groups:<br />
1. National Policies towards<br />
HIT: Efficient, effective and<br />
secure national policy can address<br />
the local health needs according to<br />
the changing environment is<br />
needed. These policies can be<br />
devised by policy makers and<br />
practitioners to assess and<br />
implement research evidences.<br />
Enforcing the legislation is<br />
difficult in developing countries<br />
and acceptance by the community<br />
for the transformation <strong>of</strong> any<br />
system is hard.<br />
2. Poor eHealthcare design:<br />
Many e-healthcare systems are<br />
developed by Information<br />
Technology (IT) solution<br />
companies which operate for the<br />
purpose <strong>of</strong> getting pr<strong>of</strong>it. These<br />
companies are interested with the<br />
financial gain from e-healthcare<br />
products that they produce. They<br />
concentrate much in producing<br />
usable products for healthcare<br />
institutions and hence causing<br />
privacy, security and<br />
confidentiality to suffer. In order<br />
to resolve this, efforts to secure e-<br />
healthcare systems need to be<br />
taken from design <strong>of</strong> the systems<br />
to implementation in order for the<br />
developments that have been<br />
achieved so far to be rolled to the<br />
real world.<br />
3. Organizational Barriers:<br />
Organizations and people play a<br />
very critical role in implementing<br />
and transformation <strong>of</strong> an<br />
information system. First <strong>of</strong> all<br />
there are no documented studies<br />
available regarding level and use,<br />
benefits, cost, risk analysis and<br />
other aspects <strong>of</strong> health technology<br />
in health sector <strong>of</strong> underdeveloped<br />
countries and if they are available<br />
for the developing countries they<br />
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are not well communicated.<br />
Secondly, people at higher<br />
positions and posts, whose needs<br />
<strong>of</strong> reporting are adequately being<br />
catered by the existing system, do<br />
not favor HIT as they think that<br />
the employment <strong>of</strong> new<br />
technology is wastage <strong>of</strong> both the<br />
money and time. Hospitals must<br />
address the apprehension <strong>of</strong><br />
physicians because if by using<br />
HIT their pr<strong>of</strong>essional<br />
responsibilities become difficult<br />
they will never support its use.<br />
4. Social and Cultural<br />
Barriers: Digital divide and e-<br />
readiness are major social and<br />
cultural barriers in establishment<br />
and use <strong>of</strong> health information<br />
system. These barriers include<br />
lack <strong>of</strong> stakeholder’s interest, less<br />
motivation, anxiety to adapt and<br />
use new technology. Health care<br />
personnel are difficult to convince<br />
for use <strong>of</strong> new health<br />
technologies. As they are more<br />
comfortable with their<br />
conventional approach and<br />
routine practice so it is<br />
complicated to transform health<br />
information system from paper<br />
based to digital format (Durrani et<br />
al., 2012).<br />
5. Infrastructure-related<br />
Issues: Most <strong>of</strong> underdeveloped<br />
countries do not have required<br />
technological infrastructure to<br />
establish national health<br />
information system hence cannot<br />
promote HIT in private and<br />
public hospitals. Reshaping<br />
infrastructure <strong>of</strong> existing health<br />
system is very crucial. Most<br />
developing countries do not have<br />
adequate required infrastructure<br />
such as computer hardware,<br />
s<strong>of</strong>tware, wired and wireless<br />
communication channels,<br />
Internet, and skilled pr<strong>of</strong>essional<br />
human resource. The availability<br />
and operation <strong>of</strong> these<br />
components <strong>of</strong> digital<br />
Infrastructure are necessary for<br />
establishment and promotion <strong>of</strong><br />
HIT in under developed<br />
countries. Strong infrastructure is<br />
required for the strong health<br />
information system to improve<br />
existing health system by<br />
planning and introducing new<br />
health care interventions which<br />
results in achieving better health<br />
goal. There are poor or inadequate<br />
resources allocation for<br />
implementation and use <strong>of</strong> the<br />
health technology in the<br />
developing countries.<br />
6. Hardware/S<strong>of</strong>tware: HIT<br />
requires specialized s<strong>of</strong>tware and<br />
hardware to improve public health<br />
by making evidence based<br />
decisions. Often these s<strong>of</strong>tware<br />
and hardware tools are costly and<br />
require sufficient training for<br />
proper operation.<br />
7. Poor Availability <strong>of</strong><br />
Internet: Poor internet availability<br />
is a vital infrastructure barrier.<br />
Health care specialists have poor<br />
access to real time information<br />
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Q. A. Qureshi et al. 41<br />
and the available information is<br />
not according to the local<br />
situation. This available<br />
information cannot be used for<br />
evidence based decisions. Without<br />
having a proper local area network<br />
and internet facility interorganizational<br />
and intraorganizational<br />
communication is<br />
not possible. This is a backbone<br />
for any information system.<br />
8. Lack <strong>of</strong> Pr<strong>of</strong>essionals &<br />
their Trainings: A computerized<br />
information system requires<br />
skilled personnel for its effective<br />
operation. Training is one <strong>of</strong> the<br />
aspects for use <strong>of</strong> any new<br />
technology. Deficiency <strong>of</strong> skilled<br />
workforce can be overcome by<br />
providing appropriate training in<br />
the required area. A proper<br />
training module in constructing<br />
architecture <strong>of</strong> a reliable database<br />
should be available. If it is not<br />
implemented then outcomes or<br />
results gained by such type <strong>of</strong><br />
databases gives unauthentic<br />
results which can neither be used<br />
for decision making process nor<br />
for evidence based practice.<br />
Training requires cost as well as<br />
time.<br />
9. Cost and Time<br />
Constraints: Major problem in<br />
organizing workshops and<br />
trainings for establishment and<br />
implementation <strong>of</strong> HIT in under<br />
developed countries is financial<br />
and time constraint.<br />
Transformation <strong>of</strong> any system is a<br />
difficult task and cannot complete<br />
in short time period. Barriers like<br />
lack <strong>of</strong> skilled workforce,<br />
infrastructure, and cost along with<br />
other effects like initial decrease<br />
<strong>of</strong> productivity due to adjustment<br />
with new technological<br />
environment and system itself<br />
impose strong limits to the<br />
introduction and adoption <strong>of</strong> new<br />
health technologies. It requires<br />
years and years for transformation<br />
process to complete.<br />
10. Educational Barriers:<br />
Pr<strong>of</strong>essional education in health<br />
informatics is badly ignored and<br />
missing in curriculum <strong>of</strong> medical<br />
institutes for undergraduates.<br />
Although module <strong>of</strong> education<br />
related to IT use in research is<br />
included in postgraduate<br />
curriculum but it is the need <strong>of</strong><br />
the hour to include this area in<br />
medical pr<strong>of</strong>essional education at<br />
graduate level. Transformation <strong>of</strong><br />
our existing paper based health<br />
system into computerized<br />
information system is not possible<br />
without providing the basic IT<br />
knowledge to health pr<strong>of</strong>essionals.<br />
11. Fear <strong>of</strong> losing Control over<br />
Data: The shift from traditional<br />
healthcare to e-healthcare<br />
involves the transformation <strong>of</strong><br />
records from paper-based to<br />
digital format. These records are<br />
referred to as Electronic<br />
Healthcare Record (EHR).<br />
Grimson (2001) defines and<br />
characterizes the next generation<br />
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EHR as the longitudinal cradle-tograve<br />
records readily accessible<br />
and available over the Internet.<br />
These records will be linked to<br />
clinical protocols and guidelines to<br />
drive the delivery <strong>of</strong> healthcare to<br />
the individual. The presence <strong>of</strong><br />
these records over the Internet<br />
facilitates record sharing between<br />
physicians. However, patients<br />
usually feel that they are losing<br />
control <strong>of</strong> their data hence<br />
resisting e-healthcare adoption.<br />
3.2 Prospects <strong>of</strong> e-Health in<br />
Pakistan<br />
The healthcare facilities in<br />
Pakistan has got better and<br />
increased in figure each year but<br />
this increase is not proportionate<br />
to the population growth<br />
.Therefore; the healthcare<br />
facilities are not that enough<br />
which can fulfill the needs and<br />
necessities <strong>of</strong> a large population.<br />
Persons particularly in rural areas<br />
face more difficulties <strong>of</strong> poor<br />
health than the people living in<br />
urban areas. Likewise, there has<br />
been a rise in expenses on<br />
healthcare planning and<br />
implementation but these<br />
expenditures on more and<br />
expanded healthcare setups are<br />
not enough for the population<br />
which is growing faster than the<br />
increase in the expenditure<br />
(Saleem, 2009). Moreover, there is<br />
also an increase in the number <strong>of</strong><br />
doctors, dentists and physicians<br />
every year .The increase in<br />
doctors and dentists number is<br />
more than the population growth<br />
which has decreased the number<br />
<strong>of</strong> patients/people for each doctor<br />
and dentist for treatment.<br />
In the present times <strong>of</strong><br />
management, a practical and<br />
structured information system is<br />
more or less a need and main<br />
concern <strong>of</strong> many organizations<br />
especially the healthcare<br />
institutions. In Pakistan, the old<br />
techniques and methods for data<br />
collection and analysis must be<br />
changed if the information in<br />
healthcare sector is to be used<br />
correctly for more effective<br />
healthcare-related activities and<br />
decisions. The Ministry <strong>of</strong><br />
Health, Government <strong>of</strong> Pakistan,<br />
in alliance with the provincial<br />
health departments and<br />
international agencies developed a<br />
National HMIS during 1990-93<br />
(Ali & Horikoshi, 2002). The<br />
facility based HMIS is one <strong>of</strong> the<br />
most influential tool for the<br />
planning and management <strong>of</strong><br />
healthcare services. In view <strong>of</strong> the<br />
existing huge health<br />
infrastructure, stretched all over<br />
the country in terms <strong>of</strong> health<br />
facilities, services, staff, drugs and<br />
supplies etc. there has been a<br />
requirement to start a wellorganized<br />
information system<br />
responding to the information<br />
needs <strong>of</strong> various decision making<br />
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levels <strong>of</strong> the healthcare<br />
organizations(Durrani &<br />
Khoja, 2009).<br />
The relationship between the<br />
ICTs and better healthcare<br />
service delivery has been<br />
discussed significantly<br />
(Ferraro, 2008; Nowak, 2008).<br />
The present studies have<br />
focused on the introduction <strong>of</strong><br />
particular technologies, such as<br />
the cell phone or the Internet,<br />
but few have examined<br />
empirically the relationship in<br />
detail (Fraser et al.,2007;<br />
Kollmann et al., 2007). One<br />
probable method <strong>of</strong> tackling<br />
this dispute is appraisal and<br />
evaluation <strong>of</strong> user needs before<br />
adoption and use <strong>of</strong> eHealth<br />
systems. However, user studies<br />
which can be very helpful and<br />
productive for adoption <strong>of</strong> ITapplications<br />
in healthcare<br />
sector but unfortunately these<br />
studies are not always carried<br />
out at the right time in design<br />
and development cycle<br />
(Saleem, 2010).<br />
A lot <strong>of</strong> healthcare<br />
organizations implement<br />
telemedicine technology for the<br />
development <strong>of</strong> healthcare<br />
services and increase usefulness<br />
& effectiveness. The<br />
willingness <strong>of</strong> healthcare<br />
organizations and the<br />
availability <strong>of</strong> the suitable<br />
conditions are driving forces for<br />
the implementation and use <strong>of</strong><br />
telemedicine. Earlier studies<br />
showed that a telemedicine<br />
program can be disobeyed by<br />
organizational culture and work<br />
processes (Wootton, 2008)<br />
One main obstruction in e-<br />
Healthcare implementation, either<br />
in developed or developing states<br />
is privacy, secrecy and security<br />
concerns <strong>of</strong> e-Health systems.<br />
The American government, for<br />
example, for the year 2009<br />
reserved 19 billion dollars for ITapplications<br />
in healthcare sector.<br />
However, in spite <strong>of</strong> this massive<br />
investment, e-healthcare adoption<br />
in the USA is still hesitant. Its<br />
expected users for instance<br />
doctors and physicians are not<br />
convinced about the security<br />
issues and concerns <strong>of</strong><br />
information systems in healthcare<br />
organizations therefore they resist<br />
the implementation and use <strong>of</strong> the<br />
same. Furthermore, patients are<br />
also worried about the privacy <strong>of</strong><br />
their medical records. This has<br />
been influenced by a number <strong>of</strong><br />
existing cases involving violations<br />
in e-healthcare information<br />
systems. However, we disagree<br />
that adoption <strong>of</strong> eHealth systems<br />
is not a financial problem as such.<br />
It goes beyond, to include human<br />
faith and belief. Therefore, in<br />
spite <strong>of</strong> concentrating on securing<br />
funds for e-healthcare<br />
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implementation, developing states<br />
have to think about the human<br />
factor as well (Durrani & Khoja,<br />
2009).<br />
Though we suggest the use <strong>of</strong> Free<br />
and Open Source S<strong>of</strong>tware<br />
(FOSS) (from operating system<br />
to EHR s<strong>of</strong>tware) but due to<br />
shortage <strong>of</strong> money, these products<br />
are linked with many challenges.<br />
As these products are “free”, its<br />
users do not have any support and<br />
maintenance from development<br />
teams. The government <strong>of</strong><br />
developing countries needs to set<br />
aside sufficient finances for staff<br />
training in the healthcare sector.<br />
If e-health is to succeed in<br />
developing nations it needs to be<br />
take care <strong>of</strong>. We need to develop<br />
our own local abilities and<br />
infrastructure, based on local<br />
demand.<br />
The shared understanding and<br />
collaboration is a coordinated,<br />
synchronous activity that is the<br />
outcome <strong>of</strong> a continued effort to<br />
construct and uphold a shared<br />
conception <strong>of</strong> a problem.<br />
Cooperation is working jointly to<br />
achieve shared goals surrounded<br />
by joint and supportive activities<br />
individuals look for results which<br />
are advantageous to themselves<br />
and helpful to all other group<br />
members. Methodically and<br />
thoroughly structuring those basic<br />
elements into group learning<br />
circumstances helps ensure joint<br />
efforts and makes possible the<br />
closely controlled implementation<br />
<strong>of</strong> joint learning for lasting<br />
success (Kaplan, 2000). The<br />
advantages <strong>of</strong> collaborative<br />
learning are that persons bring<br />
different ideas in a collaborative<br />
environment and work on the<br />
way to the growth <strong>of</strong> a shared<br />
understanding and building usual<br />
knowledge (Tan , 2005). At<br />
present, the existing<br />
understanding seems to be that<br />
collaboration is a synonym for<br />
high-quality learning and good<br />
educational technology; more or<br />
less any web-based application is<br />
labeled as collaboration<br />
(Heinzelmann et al., 2003).<br />
Ever increasing charges for<br />
healthcare services and fast<br />
increase and development <strong>of</strong> the<br />
knowledge have led the doctors<br />
and physicians to work in a<br />
collaborative way and share<br />
knowledge and skills. It is usually<br />
understood that healthcare<br />
pr<strong>of</strong>essionals working in a<br />
collaborative style, can deliver<br />
healthcare services in a successful<br />
and well-organized manner.<br />
Collaborative learning process can<br />
exchange <strong>of</strong> ideas within little<br />
groups not only enhances interest<br />
between the participants but also<br />
generates and encourages critical<br />
thinking. Collaboration in<br />
healthcare organizations requires<br />
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Q. A. Qureshi et al. 45<br />
establishing a platform, and<br />
governmental responsibility to<br />
support sharing knowledge and<br />
experiences among healthcare<br />
workers (Durrani & Khoja, 2009).<br />
Collaboration and healthcare<br />
teams are very common in<br />
hospitals for durable and lasting<br />
healthcare facilities, but teams are<br />
<strong>of</strong>ten not available to providers in<br />
the community where the<br />
majority <strong>of</strong> practitioners work<br />
separately. Collaboration makes<br />
group members more adaptable<br />
and ultimately replaceable as the<br />
group as a learning community<br />
shares knowledge and<br />
experiences. Collaborative<br />
learning in healthcare<br />
organizations need to make and<br />
establish the environment that<br />
supports and encourages sharing<br />
<strong>of</strong> knowledge such as: government<br />
policy, IT infrastructure, top<br />
management support, and<br />
business process management to<br />
give doctors and physicians the<br />
capability <strong>of</strong> discussion and<br />
reflection (Scott et al., 2005).<br />
Pakistan’s ministry for healthcare<br />
has forecasted that Pakistan is<br />
grasping important benefits from<br />
the up-and-coming information<br />
economy. This is reflected in the<br />
current infrastructure investment<br />
and other hi-tech developments.<br />
In spite <strong>of</strong> this development, it<br />
seems that Pakistan is very slow<br />
in healthcare services provision.<br />
The slow adoption and use <strong>of</strong> ITapplications<br />
in the developing<br />
states like India and Pakistan is<br />
because <strong>of</strong> lack <strong>of</strong> management<br />
support (the perceived complexity<br />
and cost (Li et al., 2005, Houston<br />
et al., 2003, Lu et al., 2003);<br />
sensitive character and make-up<br />
<strong>of</strong> information and logistics<br />
contained in a healthcare facility,<br />
nature and type <strong>of</strong> risk involved,<br />
demands for high quality <strong>of</strong><br />
healthcare, high litigation cost and<br />
lack <strong>of</strong> infrastructure, the level <strong>of</strong><br />
absorption and assimilation with<br />
existing health systems(Li et al.,<br />
2005) and the requirement for<br />
other resources to support<br />
technology infrastructure<br />
(Davenport, 2005, Lu et al., 2003).<br />
While there is an increase in the<br />
usage <strong>of</strong> new technologies but<br />
there are limited studies on the<br />
perceptions and awareness <strong>of</strong><br />
doctors and physicians about the<br />
adoption and use <strong>of</strong> ITapplications<br />
in healthcare sector<br />
(Eastes, 2001, Li et al., 2005).<br />
Earlier studies that have used<br />
existing models to predict<br />
behavior determinants <strong>of</strong> adoption<br />
<strong>of</strong> technologies in healthcare have<br />
demonstrated their inadequacy.<br />
Further, the uptake <strong>of</strong> wireless<br />
and handheld tools and devices is<br />
either on a very small level on an<br />
individual level but are not at<br />
organizational levels in Pakistan.<br />
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There is limited research available<br />
on determinants and factors that<br />
are critical to understanding user<br />
perceptions <strong>of</strong> technologies<br />
specific to healthcare on a larger<br />
scale. Therefore, any knowledge<br />
<strong>of</strong> these factors <strong>of</strong> adoption <strong>of</strong><br />
new technology will help the<br />
healthcare administrators to<br />
develop suitable policies in order<br />
to handle the ever-increasing<br />
demands <strong>of</strong> healthcare services.<br />
This is more valid in the case <strong>of</strong><br />
Pakistan because <strong>of</strong> the demands<br />
placed on the healthcare services<br />
and rising interest in wireless<br />
technologies in the health domain.<br />
The culture <strong>of</strong> Pakistani<br />
environment has always<br />
encouraged the use <strong>of</strong> technology.<br />
This is high on the programs and<br />
plans at country and federal level<br />
government. The healthcare<br />
sector in Pakistan is operating in<br />
an environment <strong>of</strong> strong<br />
regulatory framework, cost<br />
reduction, high competition, and<br />
expectation <strong>of</strong> high quality <strong>of</strong><br />
services, high demand on the<br />
healthcare sector, limited<br />
resources, and the demand for<br />
providing high quality <strong>of</strong> care -<br />
anytime anywhere. Factors such<br />
as familiarity, infrastructure, cost,<br />
clinical process, quality <strong>of</strong> care,<br />
management support, policies and<br />
procedures, security, availability<br />
<strong>of</strong> appropriate wireless<br />
application, trust and knowledge<br />
<strong>of</strong> the technology will facilitate<br />
the adoption and hence the use <strong>of</strong><br />
wireless handheld devices in<br />
Pakistani healthcare environment.<br />
4. Discussions<br />
The process <strong>of</strong> developing and<br />
implementing IS in the context <strong>of</strong><br />
developing countries is a<br />
challenging endeavor. This<br />
challenge mainly emanates from<br />
existing adverse situation <strong>of</strong> the<br />
installed base that is characterized<br />
by uneven infrastructural<br />
development across regions,<br />
inadequate skilled manpower, lack<br />
<strong>of</strong> integration <strong>of</strong> exiting<br />
standards, work practices, and<br />
varying political commitment and<br />
organizational support at different<br />
levels (Raghupathi & Wu, 2011).<br />
Simply acquiring and<br />
implementing e-Health<br />
technology alone would be<br />
insufficient to accomplish clinical<br />
performance and, subsequently,<br />
drive adoption and diffusion. E-<br />
Health technology should be<br />
integrated effectively with the<br />
organizational change and<br />
improvement (Asangansi et al.,<br />
2008). The improvement in<br />
processes requires the<br />
optimization <strong>of</strong> clinical functions<br />
and processes which should be<br />
supported by the technology and<br />
not driven by it. By doing this it is<br />
likely to generate significant<br />
patient outcomes and financial<br />
©2014 <strong>Mediterranean</strong> Center <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong>
Q. A. Qureshi et al. 47<br />
improvements with health<br />
organizations. This is estimated in<br />
terms <strong>of</strong> attracting more patients,<br />
saving effort and time (Bhutto et<br />
al., 2010).Furthermore, in the<br />
context <strong>of</strong> developing states like<br />
Pakistan, the cost constitutes an<br />
important factor which will affect<br />
the integration and, subsequently,<br />
the success <strong>of</strong> eHealth systems in<br />
a particular setting. Although cost<br />
aspects are not directly explored,<br />
however, efforts to save time,<br />
reduction in inaccuracies and high<br />
quality information are real<br />
components <strong>of</strong> the cost (Somu &<br />
Bhaskar,2011). While existing<br />
research suggests that wireless<br />
technology has the power to<br />
decrease scheduling time and<br />
medical errors thereby enhancing<br />
the quality in patient care, there is<br />
bleak evidence on the<br />
comparisons <strong>of</strong> costs before and<br />
after the implementation <strong>of</strong><br />
wireless technologies. It entails<br />
that there is a big space for further<br />
research to assess the hypothesis<br />
that costs have the potential to<br />
affect clinical usefulness and<br />
threaten widespread adoption<br />
(Juma et al., 2012). Use <strong>of</strong> e-health<br />
systems in developing countries<br />
holds many threats, along with<br />
the expected advantages. The<br />
main risk <strong>of</strong> using ICTs is the<br />
unintentional broadening <strong>of</strong> the<br />
gap in health status and<br />
knowledge between various<br />
segments <strong>of</strong> the population, thus<br />
escalating rather than addressing<br />
healthcare inequalities. One<br />
method to stay away from this<br />
divide is for government<br />
authorities and hospitals in<br />
developing countries to evaluate<br />
and make them ready for change<br />
before adoption and use <strong>of</strong> ITapplications.<br />
This process <strong>of</strong><br />
preparation for eHealth related<br />
change is also termed as eHealth<br />
readiness (Durrani et al., 2012).<br />
eHealth readiness is determined<br />
by assessing the comparative<br />
status <strong>of</strong> governments, healthcare<br />
organizations, or expected users in<br />
those areas most critical for<br />
acceptance and success <strong>of</strong><br />
programs using ICT (Rezai-Rad<br />
et al., 2012).<br />
5. Conclusions<br />
Literature reveals that e-Health<br />
systems are the future <strong>of</strong> every<br />
healthcare service being provided<br />
in the advanced, developing and<br />
poor states. developing states are<br />
interested and busy in the<br />
improvement <strong>of</strong> healthcare-sector<br />
and that is why these nations keep<br />
on to decentralize their political<br />
and healthcare systems, they need<br />
to make available all the required<br />
payments and grants for the weak<br />
and insufficient resources and<br />
powerless abilities and<br />
qualifications <strong>of</strong> the urban areas.<br />
Although the speed and tempo <strong>of</strong><br />
introducing digital systems for<br />
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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 31-52 48<br />
healthcare is altogether different<br />
from advanced to developing<br />
countries like Pakistan, all the<br />
states are making all out efforts to<br />
adopt these systems. This attitude<br />
is based on the fact that the ICTs<br />
have <strong>of</strong>fered such options that<br />
were almost unimaginable so far.<br />
E-Health systems are helping the<br />
developing and poor states in<br />
resolving their long standing<br />
problems in healthcare facilities<br />
and services. Furthermore, the<br />
research tells that once a country<br />
is capable to introduced e-Health<br />
system, its success depends on the<br />
users’ ‘e-Readiness’ for willingly<br />
using the new systems. A huge<br />
body <strong>of</strong> research is underway to<br />
explore the dynamics <strong>of</strong> users’<br />
readiness. There are several<br />
variables which determine the<br />
users’ attitude however the most<br />
powerful and unavoidable<br />
determinant is the ‘digitalliteracy’<br />
<strong>of</strong> the prospected users.<br />
Research shows that as the<br />
computer literacy <strong>of</strong> the e-Health<br />
users (like doctors) increases, the<br />
possibility <strong>of</strong> successful e-Health<br />
operations also increases.<br />
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