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Mediterranean Journal of Medical Sciences,aims to provide a platform for knowledge sharing among academicians, students, researchers, physicians, government entities and other non government entities. Issues : 3 per year ISSN 2385-2712 EISSN 2385-2453 http://mcmscience.org/

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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> Volume 1, Issue 1, October 2014: 1-5<br />

Original Paper<br />

Screening Program for Proteinuria in Rural Adult<br />

Population: Kirsehir, Turkey<br />

Mehmet ÖZDEMIR*, Gülay AKGÜL*<br />

*Ahi Evran University Training and Research Hospital, Kirsehir, Turkey<br />

Background & objectives: The burden <strong>of</strong> kidney disease is disproportionately high in central<br />

Anatolia, and the conditions <strong>of</strong>ten remain undiagnosed until late-stage disease. In order to<br />

reduce this burden, strategies must be implemented to improve the detection <strong>of</strong> kidney disease,<br />

and preventative measures must be targeted at those at greatest risk <strong>of</strong> disease. Important<br />

risk factors among include hypertension, diabetes, and obesity. As the exact prevalence <strong>of</strong><br />

proteinuria is not known in the general population, we undertook this study to estimate the<br />

same in a rural adult population in Kirsehir district.<br />

Methods: A survey <strong>of</strong> health and health related issues was conducted on 2524 volunteers,<br />

average age 52.19 years, selected randomly from the Kirsehir District, Turkey. A dipstick<br />

urinalysis and test for Proteinuria was performed on a clean void, untimed urine sample as a<br />

part <strong>of</strong> a 4-hour interview/examination. Ultrasound <strong>of</strong> the abdomen was done in patients<br />

with renal failure and renal biopsy was performed in selected patients.<br />

Results: Of the total 2524 individuals screened, 61.3 per cent were females. Mean age <strong>of</strong> the<br />

study population was 51.19 ± 11.2 yr. First dipstick test identified 289 individuals positive for<br />

albuminuria. Repeat dipstick could be done in only 263, <strong>of</strong> whom 117 showed persistent<br />

albuminuria. Significant proteinuria was detected in 14 individuals <strong>of</strong> the 208 who had 24 h<br />

urine protein measured. Of these 14 patients, 3 were found to have chronic renal failure, 6<br />

were presumed to have diabetic nephropathy clinically, one each had focal segmental<br />

glomerulosclerosis and biopsy proven diabetic nephropathy, and 4 patients had proteinuria <strong>of</strong><br />

unknown aetiology.<br />

Interpretation & conclusion: The prevalence <strong>of</strong> proteinuria in this adult rural population was<br />

0.47 per cent (0.30-0.67%) and Males were more affected than females. The detection and<br />

treatment <strong>of</strong> chronic kidney disease in 14 individuals is bound to reduce the rate <strong>of</strong> decline <strong>of</strong><br />

renal functions.<br />

Key words Albuminuria - dipstick - endstage renal disease - proteinuria<br />

1. Introduction<br />

Proteinuria is defined as urinary<br />

protein excretion <strong>of</strong> greater than<br />

150 mg per day. Urinary protein<br />

excretion in healthy persons<br />

varies considerably and may reach<br />

proteinuric levels under several<br />

circumstances. Most dipstick tests<br />

(e.g., Albustin, Multistix) that are


<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 1-5 2<br />

positive for protein are a result <strong>of</strong><br />

benign proteinuria, which has no<br />

associated morbidity or<br />

mortality[5] . Among the various<br />

predictors <strong>of</strong> progression <strong>of</strong><br />

chronic kidney disease to end<br />

stage renal disease (ESRD),<br />

proteinuria is the most potent<br />

predictor[6]. Angiotensin<br />

converting enzyme (ACE)<br />

inhibitors (ACEi) and angiotensin<br />

II receptor blockers (ARB) have<br />

been given to persons with<br />

proteinuria and chronic kidney<br />

disease to decrease the progression<br />

to end stage renal disease[4,7-11],<br />

treatment <strong>of</strong> proteinuric patients<br />

with ACEi and ARB has been<br />

shown to decrease the rate <strong>of</strong><br />

progression <strong>of</strong> chronic kidney<br />

disease.<br />

Since the exact prevalence and<br />

cause <strong>of</strong> proteinuria as a marker <strong>of</strong><br />

kidney disease is not known in<br />

our population, we undertook this<br />

study to estimate the same in a<br />

rural population in Kirsehir.<br />

2. Material & Methods<br />

A convenient sample <strong>of</strong> 2524<br />

adults (aged 40 yr and above)<br />

from rural area <strong>of</strong> Kirsehir, Turkey<br />

was included in the study. The<br />

study was carried out for a period<br />

<strong>of</strong> 24 months between April 2011<br />

and April 2013. Individuals were<br />

selected under an ongoing<br />

community health programme by<br />

the Department <strong>of</strong> Urology, Ahi<br />

Evran University Training and<br />

Research Hospital, Kirsehir,<br />

Turkey.<br />

After explaining about the<br />

objective <strong>of</strong> the study, individuals<br />

were tested for albuminuria by<br />

dipstick examination (Multistix<br />

SG, Bayer Diagnostics) in an<br />

untimed urine sample. Individuals<br />

who had acute illness, non<br />

ambulatory persons and<br />

menstruating women were<br />

excluded. Individuals tested<br />

positive for albuminuria<br />

underwent a second dipstick<br />

examination after a gap <strong>of</strong> one<br />

week. Repeat dipstick was<br />

performed to rule out transient<br />

proteinuria.<br />

Individuals with persistent<br />

albuminuria on the second<br />

dipstick examination underwent<br />

further evaluation at the which<br />

included medical history, physical<br />

examination, 24 h urine protein<br />

estimation, total serum protein<br />

and albumin estimation. Those<br />

who had proteinuria (protein<br />

excretion >150 mg/day on 24 h<br />

urine protein estimation)<br />

underwent urine microscopic<br />

examination, blood urea and<br />

serum creatinine, fasting and<br />

postprandial blood sugar level<br />

estimations. Ultrasound <strong>of</strong> the<br />

abdomen was done in patients<br />

with renal failure (serum<br />

creatinine >1.4 mg/dl). Renal<br />

biopsy was performed in patients<br />

with proteinuria >1 g/day or<br />

©2014 <strong>Mediterranean</strong> Center <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong>


M. ÖZDEMIR, G. AKGÜL 3<br />

proteinuria with an active urinary<br />

sediment or with renal failure. To<br />

facilitate the participation,<br />

dipstick examination for<br />

albuminuria was performed at the<br />

individual’s residence.<br />

3. Results & Discussion<br />

Of a total <strong>of</strong> 2524 individuals<br />

screened, 1548 (61.3%) were<br />

women. The age ranged from 40<br />

to 90 yr with a mean age <strong>of</strong> 51.19 ±<br />

11.2 yr. First dipstick test<br />

identified 59 individuals with<br />

positive for albuminuria. Of these,<br />

repeat dipstick could be done in 57<br />

diabetic nephropathy clinically<br />

(diabetics with proteinuria,<br />

diabetic retinopathy and inactive<br />

urinary sediment). Seven patients<br />

who had proteinuria <strong>of</strong> unknown<br />

aetiology, were not subjected to<br />

renal biopsy as criteria for biopsy<br />

were not met (proteinuria <strong>of</strong> less<br />

than 1 g/day, normal renal<br />

function and bland urinary<br />

sediment). Two patients<br />

underwent renal biopsy and it<br />

showed focal segmental<br />

glomerulosclerosis in one and<br />

diabetic nephropathy in the other<br />

The following thresholds have<br />

been considered, as summarised<br />

here:<br />

Table 1<br />

ACR<br />

PCR Implication<br />

(mg/mmol) (mg/mmol)<br />

>2.5/3.5 >15 Abnormal (ACR values are for male, female):<br />

adequate to define CKD 1 or 2.<br />

Commence ACEI/ARB if diabetic(**).<br />

30 50 Favour ACE inhibitor/ ARB if hypertensive<br />

Suffix 'p' on CKD stage<br />

70 100<br />

Referral threshold in non-diabetics<br />

>250 >300 Approximately 'nephrotic range' proteinuria<br />

individuals <strong>of</strong> whom 21 showed<br />

persistent<br />

albuminuria.<br />

Significant proteinuria was<br />

detected in 14 (8 males, 6 females)<br />

<strong>of</strong> the 20 individuals with<br />

persistent albuminuria who had 24<br />

h urine protein measured. Further<br />

evaluation <strong>of</strong> these 20 subjects<br />

revealed chronic renal failure in<br />

three by biochemical and<br />

ultrasound examinations. Twelve<br />

patients were presumed to have<br />

The prevalence <strong>of</strong> proteinuria in<br />

the study population was 0.47 per<br />

cent (0.30-0.67%) using albumin<br />

dipstick as a screening test.<br />

Prevalence in males and females<br />

was 0.75 per cent (0.35-1.14%) and<br />

0.31 per cent (0.11-0.50%)<br />

respectively (Table 2).<br />

The female preponderance in the<br />

study sample was probably a<br />

reflection <strong>of</strong> the fact that the men<br />

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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 1-5 4<br />

were away from home at work<br />

during the time <strong>of</strong> sample<br />

collection. Among the various<br />

aetiological factors, diabetic<br />

nephropathy was found in 7 <strong>of</strong> 14<br />

patients (50%) with proteinuria.<br />

Seven patients with significant<br />

proteinuria not meeting the<br />

criteria for a renal biopsy are<br />

being followed up. Patients with<br />

diabetic nephropathy were<br />

advised euglycaemic measures and<br />

are on follow up with the health<br />

department. One individual with<br />

focal<br />

segmental<br />

glomerulosclerosis was treated<br />

parts <strong>of</strong> the country may prove to<br />

be an effective measure in<br />

reducing the burden <strong>of</strong> chronic<br />

kidney disease.<br />

Acknowledgment<br />

The authors thank trained health<br />

care workers at Ahi Evran<br />

University Training and Research<br />

Hospital, Kirsehir, Turkey for<br />

their assistance in performing<br />

urine dipstick examination.<br />

Table 2. Prevalence rate <strong>of</strong> proteinuria (%) according to age and gender<br />

Age Males Females<br />

(yr) (N) Prevalence (N) Prevalence<br />

40-59 621 0.60 (0.58 - 0.62) 1050 0.62 (0.61 - 0.64)<br />

60-79 319 0.32 (0.30 - 0.34) 441 0.35 (0.347 -0.349)<br />

>80 36 0.07 (0.06 - 0.09) 57 0.03 (0.027 -0.029)<br />

Total 976 1548<br />

Values in parentheses indicate range<br />

with ACEi and has stable renal<br />

function. The risk <strong>of</strong> renal failure<br />

is greater in younger patients.<br />

In conclusion, although the<br />

prevalence <strong>of</strong> proteinuria in this<br />

rural population was low,<br />

detection and treatment <strong>of</strong> chronic<br />

kidney disease in 14 individuals<br />

with proteinuria is likely to reduce<br />

the rate <strong>of</strong> decline <strong>of</strong> renal<br />

function. Similar screening<br />

programmes for proteinuria with<br />

proper study design in different<br />

References<br />

1. Nakopoulou L, Stefananki K, Papadakis<br />

J,Boletis J, Zeis PM, Kostakis A et<br />

al. Expression <strong>of</strong> bcl-2 oncoprotein<br />

in various types <strong>of</strong><br />

glomerulonephritis and renal<br />

allografts. Nephrol Dial Transplant<br />

1996; 11: 997–1002<br />

2. Gerstein HC, Mann JF, Yi Q, et al.<br />

Albuminuria and risk <strong>of</strong><br />

cardiovascular events, death, and<br />

heart failure in diabetic and<br />

nondiabetic individuals. JAMA 2001;<br />

286 : 421-6.<br />

©2014 <strong>Mediterranean</strong> Center <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong>


M. ÖZDEMIR, G. AKGÜL 5<br />

3. James PA, Oparil S, Carter BL, et al. 2014<br />

evidence-based guideline for the<br />

management <strong>of</strong> high blood pressure<br />

in adults—report from the panel<br />

members appointed to the Eighth<br />

Joint National Committee (JNC 8).<br />

The <strong>Journal</strong> <strong>of</strong> the American <strong>Medical</strong><br />

Association. Published online<br />

December 18, 2013.<br />

4. Anastasio, P, Spitali, L, Frangiosa, A,<br />

Molino, D, Stellato, D, Cirillo, E,<br />

Pollastro, RM, Capodicasa, L, Sepe,<br />

J, Federico, P, Gaspare De Santo, N<br />

(2000) Glomerular filtration rate in<br />

severely overweight normotensive<br />

humans. Am J Kidney Dis 35 (6)<br />

1144-1148.<br />

5. Lindholm LH, Ibsen H, Dahl<strong>of</strong> B, et al.<br />

Cardiovascular morbidity and<br />

mortality in patients with diabetes<br />

in the Losartan Intervention For<br />

Endpoint Reduction in<br />

Hypertension Study (LIFE): a<br />

randomised trial against atenolol.<br />

Lancet 2002; 359 : 1004-10.<br />

6. Jafar TH, Schmid CH, Landa M, et al.<br />

Angiotensin-converting enzyme<br />

inhibitors and progression <strong>of</strong><br />

nondiabetic renal disease: a metaanalysis<br />

<strong>of</strong> patient-level data. Ann<br />

Intern Med 2001; 135 : 73-87.<br />

7. Uluhan A, Paydaş S, Sağlıker Y, Demirtaş<br />

M, Bozdemir H, Sarıca Y: Low<br />

blood pressure and amyloidosis.<br />

Nephron 1995; 69: 118-119<br />

8. Agodoa LY, Appel L, Bakris GL, et al.<br />

Effect <strong>of</strong> ramipril vs amlodipine on<br />

renal outcomes in hypertensive<br />

nephrosclerosis: a randomized<br />

controlled trial. JAMA 2001; 285 :<br />

2719-28.<br />

9. Lewis EJ, Hunsicker LG, Clarke WR, et al.<br />

Renoprotective effect <strong>of</strong> the<br />

angiotensin-receptor antagonist<br />

irbesartan in patients with<br />

nephropathy due to type 2 diabetes.<br />

N Engl J Med 2001; 345 : 851-60.<br />

10. Brenner BM, Cooper ME, de Zeeuw D, et<br />

al. Effects <strong>of</strong> losartan on renal and<br />

cardiovascular outcomes in patients<br />

with type 2 diabetes and<br />

nephropathy. N Engl J Med 2001; 345<br />

: 861-9.<br />

11. Saatçi Ü, Özdemir S, Özen S, Bakkaloğlu<br />

A: Serum concentration and urinary<br />

excretion <strong>of</strong> beta 2 microglobulin<br />

and microalbuminuria infamilial<br />

<strong>Mediterranean</strong> fever. Arch Dis<br />

Child 1994; 70: 27-29<br />

12. Aktuğ H, Çetintaş VB, Kosova B, Oltulu<br />

F, Demiray ŞB, Çavuşoğlu T et al.<br />

Dysregulation <strong>of</strong> nitric oxide<br />

synthase activity and Bcl-2 and<br />

caspase-3 gene expressions in renal<br />

tissue <strong>of</strong> streptozotocin-induced<br />

diabetic rats. Turk J Med Sci 2012;<br />

42: 830–8<br />

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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> Volume 1, Issue 1, October 2014: 7-12<br />

Original Paper<br />

Urinary Tract Infections (UTI) Among Patients at the<br />

University Hospital Center "Mother Theresa", Tirana,<br />

Albania.<br />

Selam Shkurti*<br />

*Department <strong>of</strong> Emergency, University Hospital Center "Mother Theresa", Tirana, Albania.<br />

Abstract<br />

Background & objectives: The resistance <strong>of</strong> bacteria causing urinary tract infection (UTI) to<br />

commonly prescribed antibiotics is increasing both in developing as well as in developed<br />

countries. Resistance has emerged even to more potent antimicrobial agents. The primary<br />

objective <strong>of</strong> the study was 1) to detect the prevalence rate <strong>of</strong> bacterial infection among urinary<br />

isolates from patients having UTI and 2)to detect prevalence rate <strong>of</strong> drug resistance among<br />

pathogen isolate from patients having UTI.<br />

Methods: Early morning mid-stream urine samples were collected using sterile, wide<br />

mouthed container with screw cap tops. On the urine sample bottles were indicated name, age,<br />

sex, and time <strong>of</strong> collection along with requisition forms.<br />

Results:. Significant association (P


<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 7-12 8<br />

least 59% <strong>of</strong> cases. Other less<br />

common pathogens include<br />

Klebsiella, Proteus, Enterobacter<br />

spp, etc.<br />

To be mentioned that the<br />

distribution <strong>of</strong> pathogens that<br />

cause UTI is changing. There are<br />

several factors and abnormalities<br />

<strong>of</strong> UTI that interfere with its<br />

natural resistance to infections.<br />

These factors include sex and age<br />

disease, hospitalization and<br />

obstruction in urinary tract.<br />

The treatment <strong>of</strong> UTIs varies<br />

according to the age <strong>of</strong> the patient,<br />

sex, underlying disease, infecting<br />

agent and whether there is lower<br />

or upper urinary tract<br />

involvement. Diagnosis <strong>of</strong> UTI<br />

<strong>of</strong>ten requires laboratory<br />

examination <strong>of</strong> a urine sample in<br />

addition to clinical evaluation.<br />

Although many guidelines<br />

indicate that the culture <strong>of</strong> urine is<br />

not required in most cases <strong>of</strong><br />

uncomplicated cystitis[1], the<br />

laboratory in UHC Mother<br />

Teresa, accepts all such requests<br />

from patients to send samples on<br />

all suspected UTI.<br />

With the increasing trend <strong>of</strong><br />

antibiotic-resistance in E. coli, the<br />

management <strong>of</strong> urinary tract<br />

infections is likely to become<br />

complicated with limited<br />

therapeutic options.<br />

2. Material & Methods<br />

Study site: The study was carried<br />

out in the Department <strong>of</strong><br />

Emergency, University Hospital<br />

Center "Mother Theresa", Tirana,<br />

Albania from November 2006 to<br />

September 2007.<br />

This was an analysis <strong>of</strong> data<br />

generated from the records <strong>of</strong><br />

consecutive urine samples<br />

received in the laboratory during<br />

the study period.<br />

Analysis <strong>of</strong> the data was carried<br />

out focusing on the age, gender,<br />

whether admitted or not, whether<br />

received prior antibiotic therapy,<br />

any surgical or gynaecological<br />

intervention performed in the<br />

recent past, and any history <strong>of</strong><br />

urinary tract infection in the past.<br />

The antibiotic susceptibility data<br />

<strong>of</strong> all isolates were also reviewed<br />

and analyzed. Samples received<br />

included mid-stream clean catch<br />

urine, suprapubic aspirate, urine<br />

collected from Foley’s catheter<br />

and from the nephrostomy tube<br />

under sterile precautions, in<br />

patients who had undergone<br />

percutaneous nephrostomy.<br />

Samples were processed and<br />

isolates were identified as per<br />

standard methods 14. All urine<br />

samples were inoculated onto<br />

cysteine lactose electrolyte<br />

deficient (CLED) medium using a<br />

calibrated loop (volume-0.005 ml)<br />

and were incubated for 18-24 h at<br />

37˚C. Wet mount preparations<br />

©2014 <strong>Mediterranean</strong> Center <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong>


S. Shkurti 9<br />

were also made from all urine<br />

samples to look for pus cells and<br />

epithelial cells. Depending upon<br />

the number <strong>of</strong> the colonies grown<br />

on the CLED medium, the<br />

interpretations <strong>of</strong> urine culture<br />

were made as insignificant (50 -


<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 7-12 10<br />

males) had positive culture result<br />

and there was a statistically<br />

significant relation between<br />

gender and UTI (p=0.005).<br />

Wet mount microscopy for<br />

presence <strong>of</strong> bacteria or pus cells in<br />

significant amount per field had<br />

sensitivity, specificity, positive<br />

predictive value (PPV) and<br />

negative predictive value (NPV)<br />

<strong>of</strong> 83, 58, 44 and 89 per cent,<br />

respectively in detecting<br />

infections.<br />

Of the 2876 culture positives, E.<br />

coli was the most common (59%)<br />

isolate. (Table I).<br />

4. Discussion<br />

Cipr<strong>of</strong>loxacin and <strong>of</strong>loxacin are<br />

the most extensively used<br />

fluoroquinolones for the<br />

treatment <strong>of</strong> UTIs. This study<br />

showed that E. coli was the<br />

commonest pathogen causing<br />

complicated and uncomplicated<br />

UTI as described previously[1]<br />

[3]. There are several organisms<br />

known to cause UTIs, including<br />

P. aeruginosa, S. saprophyticus,<br />

S.epidermidis, Enterococcus spp,<br />

P. mirabilis, Klebsiella spp.,<br />

Citrobacter spp, etc. as reported by<br />

earlier workers[4]. This study also<br />

demonstrates the emergence <strong>of</strong> E.<br />

faecalis and the non-fermenters<br />

Acinetobacter spp and Pseudomonas<br />

spp as major uropathogens<br />

especially in the patients admitted<br />

in the hospitals, more so in the<br />

intensive care units. Such findings<br />

have been documented<br />

elsewhere[5-16]. The percentage <strong>of</strong><br />

isolates <strong>of</strong> E.coli resistant to<br />

ampicillin was found to be as<br />

much as 80 per cent in our set up.<br />

Such high levels <strong>of</strong> resistance to<br />

ampicillin have been quoted by<br />

many other studies from different<br />

parts <strong>of</strong> Albania[5]. Our MIC<br />

results showed that<br />

fluoroquinolone resistance<br />

increased significantly with<br />

patient’s age. An MIC <strong>of</strong> 256<br />

μg/ml was noted in the age group<br />

<strong>of</strong> >60 yr <strong>of</strong> age. There could be<br />

two explanations for this. Firstly,<br />

as a consequence <strong>of</strong> frequent<br />

exposure to fluoroquinolones<br />

resulting from the treatment <strong>of</strong><br />

repeated infections in elderly<br />

leads to increase in MIC <strong>of</strong><br />

fluoroquinolone19. Secondly,<br />

unlike urinary tract infections<br />

(UTIs) in females, UTIs in males<br />

are frequently complicated and are<br />

more likely to require prolonged<br />

antimicrobial therapy, especially<br />

in the elderly, potentially<br />

explaining the fluoroquinolone<br />

the higher MIC[25].<br />

©2014 <strong>Mediterranean</strong> Center <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong>


S. Shkurti 11<br />

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1. Vellinga A, Cormican M, Hanahoe<br />

B, Murphy AW: Predictive<br />

value <strong>of</strong> antimicrobial<br />

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treatment <strong>of</strong> re-infection. Br J<br />

Gen Pract 2010, 60:511-513.<br />

2. Gatermann SG. Bacterial infections <strong>of</strong><br />

the urinary 1. tract. In: Borriello<br />

P, Murray PR, Funke G. editors.<br />

Topley & Wilson’s microbiology &<br />

microbial infections, 10th ed. vol.<br />

III. London: Hodder Arnold<br />

Publishers; 2007. p. 671-83.<br />

3. Karlowsky JA, Jones ME, Thornsberry<br />

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DF. Prevalence <strong>of</strong> anti microbial<br />

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outpatients across the US in<br />

1999. Int J Antimicrob Agents 2001;<br />

18 : 121-7.<br />

4. Gorbach SL, Bartlett JG, Balcklow<br />

NR. Urinary tract. In: Gorbach<br />

SL, Bartlett JG, Balcklow NR,<br />

editors. Infectious diseases.<br />

Philadelphia: Lippincott<br />

Williams & Wilkins Publishers;<br />

2004. p. 861-81.<br />

5. Idrizi, Alma, et al. "Urinary tract<br />

infections in polycystic kidney<br />

disease." Med Arh 65.4 (2011): 213-<br />

5.<br />

6. Zervos MJ, Hershberger E, Nicolau<br />

DP, Ritchie DJ, Blackner LK,<br />

Coyle EA, et al. Relationship<br />

between fluoroquinolone use<br />

and changes in susceptibility to<br />

fluoroquinolones <strong>of</strong> selected<br />

pathogens in 10 United States<br />

teaching hospitals, 1991-2000.<br />

Clin Infect Dis 2003; 37 : 1643-8.<br />

7. Arslan H, Azap OK, Ergönül<br />

O,Timurkaynak F. Risk factors<br />

for cipr<strong>of</strong>loxacin resistance<br />

among Escherichia coli strains<br />

isolated from communityacquired<br />

urinary tract infections<br />

in Turkey. J Antimicrob<br />

Chemother 2005; 56 : 914-8.<br />

8. Karlowsky JA, Kelly LJ, Thornsberry<br />

C,Jones ME, Sahm DF. Trends<br />

in antimicrobial resistance<br />

among urinary tract<br />

9. Kahlmeter G. An international survey<br />

<strong>of</strong> 8. the antimicrobial<br />

susceptibility <strong>of</strong> pathogens from<br />

uncomplicated urinary tract<br />

infections: the ECO·SENS<br />

Project. J Antimicrob Chemother<br />

2003; 51 : 69-76.<br />

10. Anjum F, Kadri SM, Ahmad I,<br />

Ahmad S. A study <strong>of</strong> recurrent<br />

urinary tract infection in women<br />

attending the outpatient<br />

department <strong>of</strong> SMHS hospital,<br />

Srinagar, Kashmir, India. JK -<br />

Practitioner 2004; 11 : 272-3.<br />

11. Kauser Y, Chunchanur SK, Nadagir<br />

SD, Halesh LH,<br />

Chandrashekhar MR. Virulence<br />

factors, serotypes and<br />

antimicrobial susceptibility<br />

patterns <strong>of</strong> Escherichia coli in<br />

urinary tract infections. AJMS<br />

2009; 2 : 47-51.<br />

12. Pais P, Khurana R, George J. Urinary<br />

tract infections: A retrospective<br />

survey <strong>of</strong> causative organisms<br />

and antibiotics prescribed in a<br />

tertiary setting. Indian J<br />

Pharmacol 2002; 34 : 278-80.<br />

13. Ena J, Amador C, Martinez C, Ortiz<br />

de la Tabla V. Risk factors for<br />

acquisition <strong>of</strong> urinary tract<br />

infections caused by<br />

cipr<strong>of</strong>loxacin-resistant<br />

Escherichia coli. J Urol 1995; 153<br />

:117-20.<br />

14. Tabibian JH, Gornbein J, Heidari A,<br />

Dien SL, Lau VH, Chahal P, et<br />

al. Uropathogens and host<br />

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characteristics. J Clin Microbiol<br />

2008; 46 : 3980-6.<br />

15. Collee JG, Duguid JP, Fraser AG,<br />

Marmion BP, Simmons A.<br />

Laboratory strategy in the<br />

diagnosis <strong>of</strong> infective<br />

syndromes. In: Collee JG, Fraser<br />

AG, Marmion BP, Simmons A,<br />

editors. Mackie & McCartney<br />

practical medical microbiology, 14th<br />

ed. New York: Churchill<br />

Livingstone; 1999. p. 84-90.<br />

16. James HJ, John DT. Susceptibility<br />

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Disk Diffusion methods. In:<br />

Murray PR, Baron EJ, Jorensen<br />

JH, Landry ML, Michael AP,<br />

editors. Manual <strong>of</strong> clinical<br />

microbiology, 10th ed.<br />

Washington, D.C.: American<br />

Society for Microbiology Press;<br />

2007. p. 1152-72.<br />

17. Clinical Laboratories Standards<br />

Institute (CLSI). Performance <strong>of</strong><br />

standards for antimicrobial disk<br />

susceptibility tests;approved<br />

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Leblebicioglu H, Sunbul M.<br />

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urinary tract infection. Int<br />

JAntimicrob Agents 2002; 20 : 407-<br />

11.<br />

20. Boyd LB, Atmar RL, Randall GL,<br />

Hamill RJ, Steffen D,<br />

Zechiedrich L. Increased<br />

fluoroquinolone resistance with<br />

time in Escherichia coli from<br />

>17,000 patients at a large county<br />

hospital as a function <strong>of</strong> culture<br />

site, age, sex, and location. BMC<br />

Infect Dis 2008; 8 : 4-10.<br />

21. Hooton TM. Fluoroquinolones and<br />

resistance in the treatment <strong>of</strong><br />

uncomplicated urinary tract<br />

infection. Int J Antimicrob Agents<br />

2003; 22 : S65-S72.<br />

22. Arjunan M, Al-Salamah AA,<br />

Amuthan M. Prevalence and<br />

antibiotics susceptibility <strong>of</strong><br />

uropathogens in patients from a<br />

rural environment, Tamil Nadu.<br />

Am J Infect Dis 2010; 6 : 29-33.<br />

23. Bhargavi PS, Gopala Rao TV,<br />

Mukkanti K, Dinesh Kumar B,<br />

Krishna TP. Increasing<br />

emergence <strong>of</strong> antibacterial<br />

resistance mainly in<br />

uropathogens:southeast part <strong>of</strong><br />

India. Intl J Microbiol Res 2010; 2 :<br />

1-6.<br />

24. Gupta N, Kundra S, Sharma A,<br />

Gautam V,Arora DR.<br />

Antimicrobial susceptibility <strong>of</strong><br />

uropathogens in India. J Infect<br />

Dis Antimicrob Agents 2007; 24 :<br />

13-8.<br />

25. Manjunath GN, Prakash R, Annam<br />

V, Shetty K. Changing trends in<br />

the spectrum <strong>of</strong> antimicrobial<br />

drug resistance pattern <strong>of</strong><br />

uropathogens isolated from<br />

hospitals and community<br />

patients with urinary tract<br />

infections in Tumkur and<br />

Bangalore. Int J Biol Med Res<br />

2011; 2 : 504-7.<br />

25. Hummers-Pradier E, Koc M, Ohse<br />

AM, Heizman WR, Kochen<br />

MM. Antibiotic resistance <strong>of</strong><br />

urinary pathogens in female<br />

general practice patients. Scand J<br />

Infect Dis 2005; 37 : 256-61.<br />

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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> Volume 1, Issue 1, October 2014: 13-20<br />

Original Paper<br />

Factors affecting the introduction <strong>of</strong> ICTs for<br />

‘healthcare decision-making’ in hospitals <strong>of</strong><br />

developing countries<br />

Najam Afaq Qureshi 1 ,Qamar Afaq Qureshi 2 , Dr. Muhammad Zubair<br />

Khan 2 , Dr. Bahadar Shah 3 , Irfan Marwart 2<br />

1 Sarhad University, Pakistan, 2 Gomal University, Pakistan, 3 Hazara University, Pakistan<br />

Abstract<br />

Background & objectives: Several studies have evaluated the impacts <strong>of</strong> ICTs on decisionmaking<br />

process in both public and private health organizations but there is a dearth <strong>of</strong> such<br />

studies that integrate ICTs and effective decision making in Pakistan. Since the Pakistani<br />

governments continue to provide huge IT investment for its designated e-government<br />

agencies, the need to comprehend the impacts <strong>of</strong> ICTs on effective decision making becomes<br />

more important.<br />

Methods: This study strives to ameliorate the comprehension <strong>of</strong> the impacts <strong>of</strong> ICTs for<br />

decision-making process at all management levels <strong>of</strong> both public and private health<br />

organizations in Pakistan. Research on the information and communication technologies for<br />

decision-making is tabling new tools and techniques in the marketplace.<br />

Results: This study attempts to unearth literature review-based definition <strong>of</strong> the local<br />

decision-situations to help private and public sector organizations in Pakistan.<br />

Interpretation & conclusion: In the emerging ICTs environment, IT elements such as e-mail<br />

and group support facilities improve the coordination among the members <strong>of</strong> an organization<br />

in decision making. The use <strong>of</strong> these ICTs improves the organizational communication, which<br />

ultimately leads to effective decision-making<br />

Key words: ICTs; adoption factors; decision-making; healthcare; developing countries.<br />

1. Introduction<br />

The concept <strong>of</strong> ‘global-village’<br />

indicates high levels <strong>of</strong> interaction<br />

between nations <strong>of</strong> the world. It<br />

also reflects impacts <strong>of</strong><br />

globalization with global culture<br />

on the organizational life <strong>of</strong> public<br />

and private organizations working<br />

in both developed and developing<br />

societies (Luthans, 2002: 47).<br />

Modern organizational life is<br />

characterized with complex<br />

environments demanding the<br />

processing <strong>of</strong> huge data to analyze<br />

and diagnose complex situations<br />

(Robbins, 1998:6). It is the “fastpaced,<br />

global, highly competitive<br />

and information-intensive<br />

environment, due to which<br />

managers are facing new decision-


<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 13-20 14<br />

making challenges (Boiney,<br />

2000:33).<br />

Despite these environmental<br />

pressures, the decision-making is<br />

unanimously considered as the<br />

most important and unique<br />

function <strong>of</strong> every manager<br />

(Drucker, 1974:465; Loomba,<br />

1978:3). In this modern age<br />

traditional decision-making<br />

approach has been replaced by a<br />

systematic decision making<br />

process (Weihrich and Koontz,<br />

1999:199), which is a key factor<br />

driving the quest for information<br />

and development <strong>of</strong> supporting<br />

technologies (Boiney, 2000:32;<br />

Turban et al., 2004:544). Digital<br />

technology has influenced all<br />

sectors like business, government<br />

utility services and personal life.<br />

1.1 ICTs in health sector<br />

One <strong>of</strong> the most significant<br />

impacts <strong>of</strong> the ongoing<br />

information revolution has been<br />

on the health sector. In the field <strong>of</strong><br />

health care, ICTs have emerged as<br />

key instruments in solving many<br />

<strong>of</strong> the most pressing problems.<br />

ICT has helped to bridge the gap<br />

between the provider and seeker<br />

through telemedicine and remote<br />

consultations, enabled health<br />

knowledge management by<br />

institutions and agencies, and<br />

facilitated in the creation <strong>of</strong><br />

networks between providers for<br />

exchange <strong>of</strong> information and<br />

experiences. In fact, globally, the<br />

e-Health or health telematics<br />

sector is fast emerging as the third<br />

industrial pillar <strong>of</strong> the health<br />

sector after the pharmaceutical<br />

and the medical (imaging) devices<br />

industries(Macleod,2007).From a<br />

development perspective, ICTs<br />

are key instruments towards<br />

meeting the Millennium<br />

Development Goals (MDGs)<br />

related to health. In this respect,<br />

the increasing adoption <strong>of</strong> ICT in<br />

health care services <strong>of</strong> developing<br />

countries, by both public and<br />

private sectors, has been a<br />

welcome trend. All across the<br />

world, governments are pledging<br />

and pooling more and more <strong>of</strong><br />

their resources towards<br />

developing ICT tools and systems<br />

with the ultimate aim <strong>of</strong><br />

facilitating management,<br />

streamlining surveillance and<br />

improving health care through<br />

better delivery <strong>of</strong> preventive and<br />

curative services (Turban et al.,<br />

2004). In line with this trend the<br />

government <strong>of</strong> Pakistan in August<br />

2000, announced an integrated<br />

policy <strong>of</strong> Information<br />

Technology, which has been<br />

welcomed as step towards<br />

modernization and globalization.<br />

2. Factors affecting adoption<br />

and use <strong>of</strong> ICTs in hospitals<br />

The increasing pressure <strong>of</strong><br />

business environment <strong>of</strong> the<br />

©2014 <strong>Mediterranean</strong> Center <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong>


N. A. Qureshi et al 15<br />

information age is forcing the<br />

organizations <strong>of</strong> the entire world<br />

to adopt and use Information and<br />

communication technologies<br />

(ICTs) in decision making. It is<br />

well reported that private sector<br />

organizations are using<br />

information system for achieving<br />

strategic advantages and gaining<br />

financial and business benefits<br />

more than its public counterpart.<br />

The influence <strong>of</strong> some factors on<br />

the information system (IS)<br />

success is well documented (see<br />

for example, Ahlan, 2005; Michel<br />

& Betty, 2003); Andrew Georgiou<br />

et al., 2002). Various studies have<br />

pointed out Users, executives,<br />

Proper Organization, and external<br />

environment as the key crucial<br />

factors that influence<br />

implementation <strong>of</strong> ICTs in any<br />

organization.<br />

2.1 Users<br />

Human relations movement<br />

(behavioral approach to<br />

management) stresses that human<br />

element in an organization must<br />

be given importance in order to<br />

increase the organizational<br />

efficiency (Certo, 2001:37-38). It<br />

also emphasizes that effective<br />

human relations generate<br />

commitment <strong>of</strong> workers and high<br />

productivity in organizations.<br />

Thus management must build<br />

appropriate relationships with its<br />

people, as ability to work with<br />

people enhance organizational<br />

success. A manager under<br />

interpersonal role motivates,<br />

directs people and performs duties<br />

<strong>of</strong> social nature i.e. generates<br />

respect for each other, trusts the<br />

workers. likewise the success <strong>of</strong><br />

ICTs is not possible in the<br />

organizations whereby the human<br />

element is not given importance<br />

and where exists a lack <strong>of</strong><br />

participation <strong>of</strong> end users in IS<br />

(Information<br />

system)<br />

development proceedings as<br />

asserted by Macleod (2007) that<br />

design and implementation <strong>of</strong> the<br />

hardware/s<strong>of</strong>tware have greater<br />

success rates in the organizations<br />

whereby end users and ITstaff/pr<strong>of</strong>essionals<br />

jointly develop<br />

an information system and as<br />

Bradly (2006) says that it is the<br />

human element which is related<br />

with the adoption and success <strong>of</strong><br />

new technologies.<br />

The literature reveals that private<br />

health organizations in Pakistan<br />

are more inclined to e-government<br />

initiatives and whereby the<br />

executives <strong>of</strong> these hospitals are<br />

more interested in the adoption<br />

and use <strong>of</strong> IT in their decision<br />

making process than the<br />

management <strong>of</strong> public sector<br />

hospitals. Furthermore, private<br />

health organizations are involving<br />

the doctors, physicians and other<br />

healthcare workers in information<br />

system (IS) development.<br />

Literature also highlights that to<br />

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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 13-20 16<br />

date the private sector’s use <strong>of</strong><br />

information systems for achieving<br />

strategic advantages and gaining<br />

financial and business benefits is<br />

much greater than its public<br />

counterparts (Ahlan, 2005)”.<br />

According to Macleod et al. (2007)<br />

people have no participation in<br />

the IS development due to<br />

concept prevailing in public health<br />

organizations that their<br />

suggestions for IS development<br />

and implementations are neither<br />

welcomed nor entertained and<br />

also increases the time duration <strong>of</strong><br />

IS development. Similarly Certo<br />

(2001: 37-38) argues that<br />

organizational success can be<br />

enhanced by building appropriate<br />

relationships with the people.<br />

2.2 Executives<br />

Literature reveals that in private<br />

organizations management<br />

arranges and provides proper<br />

training to the people, the<br />

environment is friendlier,<br />

management has trust in their<br />

employees and people have<br />

respect for each other.<br />

Furthermore, results <strong>of</strong> the<br />

different studies validate the<br />

assertion that human force in<br />

private health organizations is<br />

highly qualified, pr<strong>of</strong>essional,<br />

trained and well experienced as<br />

well as more committed to the<br />

adoption and use <strong>of</strong> IT in decision<br />

making process than the<br />

managerial staff <strong>of</strong> public health<br />

organization ( see for example,<br />

Keri, 2007; Michel & Betty,2003);<br />

Avital, 2003).<br />

Executives are responsible for<br />

overall management <strong>of</strong> the<br />

organization. They establish<br />

operating policies and guide the<br />

organization’s interaction with its<br />

environment (Stoner and<br />

Wankle, 1986:15) and play<br />

different roles such as<br />

interpersonal, informational and<br />

decisional. Thus under<br />

information role they are<br />

responsible for transmitting the<br />

information received from outside<br />

or from other subordinates to the<br />

members <strong>of</strong> the organization and<br />

transmits information to outsiders<br />

on organization’s plans, policies,<br />

actions and results (Robins and<br />

Decenzo, 2006: 37). To play an<br />

informational role successfully,<br />

executives require and make the<br />

use <strong>of</strong> ICTs but our study reveals<br />

that executives <strong>of</strong> public<br />

organizations do not take interest<br />

in the adoption and use <strong>of</strong> ICTs as<br />

pinpointed by Ahlan (2005) that<br />

the executives in public health<br />

organizations do not take much<br />

interest in the adoption and use <strong>of</strong><br />

ICTs, they do not possess<br />

awareness about ICTs and have<br />

no experience <strong>of</strong> using the same<br />

for solving their unstructured<br />

problems.<br />

©2014 <strong>Mediterranean</strong> Center <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong>


N. A. Qureshi et al 17<br />

2.3 Proper Organization<br />

Proper organization helps the<br />

smooth running <strong>of</strong><br />

administration. It provides an<br />

opportunity to direct employees<br />

and coordinate their efforts. It<br />

facilitates the distribution <strong>of</strong> work<br />

among different units. It provides<br />

channels <strong>of</strong> communication,<br />

command and coordination. It<br />

fixes authority and<br />

responsibilities for each individual<br />

<strong>of</strong> an organization. All this<br />

indicates that organization has<br />

many roles to play in<br />

administrative processes. Despite<br />

all such theoretical claims<br />

literature study reveals that there<br />

is poor organization mechanism<br />

in the public health organizations,<br />

however, reasons to which are<br />

multifarious and playing different<br />

roles such as highly centralized<br />

system, limited participation,<br />

unclear role and responsibilities,<br />

lack <strong>of</strong> cooperation and<br />

coordination, absence <strong>of</strong> time<br />

work, lack <strong>of</strong> interest and<br />

commitment. This highly<br />

centralized system <strong>of</strong><br />

administration with nonparticipatory<br />

approach <strong>of</strong> the<br />

public sector organizations is the<br />

main obstacle in the ICTs success<br />

(Hage & Aiken, 1969).<br />

2.4 External environment<br />

The environment <strong>of</strong> an<br />

organization contains both<br />

supportive and antagonistic<br />

forces. An organization system<br />

derives support from clients or<br />

customers who need its products<br />

and services and from society’s<br />

protection <strong>of</strong> property and other<br />

rights. But the organization is also<br />

subject to the constraints <strong>of</strong> public<br />

regulations, demands for social<br />

responsibility, and meeting<br />

multiplicity <strong>of</strong> demand that are<br />

<strong>of</strong>ten conflicting (McFarland,<br />

1979: 290). It is part <strong>of</strong> every<br />

manager’s responsibility to be<br />

alert about the forces <strong>of</strong> external<br />

environment that affect an<br />

organization and its goal.<br />

However, findings <strong>of</strong> the study<br />

indicate that the management <strong>of</strong><br />

private health organization is<br />

more capable to fight with both<br />

external and internal environment<br />

to meet their desired objectives<br />

than to its counterparts.<br />

3. Discussions<br />

ICTs refer to how an organization<br />

transfers its inputs into outputs.<br />

Every organization has<br />

information technology that<br />

converts financial, human and<br />

physical resources into products<br />

or services ( Robbins,1998). But<br />

ICTs in private health<br />

organizations are fully compatible<br />

with the organizational systems<br />

because they are designed,<br />

developed and implemented<br />

according to an existing work<br />

patterns and requirements <strong>of</strong> an<br />

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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 13-20 18<br />

organization Hughes (2003).<br />

Similarly, Macleod (2007) argues<br />

that design and implementation <strong>of</strong><br />

the information technology have<br />

greater success rates in the private<br />

organizations because <strong>of</strong> user’s<br />

participation in information<br />

system development process. The<br />

literature reveals that information<br />

technology is making the greatest<br />

impact on the nature <strong>of</strong><br />

management thereby forcing the<br />

managers to adapt themselves<br />

with the emerging new trends<br />

(Haiman et al., 1985:37). Similarly,<br />

Boiney (2000:32) and Turban, et<br />

al. (2004:549) argues that the need<br />

to speed up, coordinate and<br />

improve the aspects <strong>of</strong> decisionmaking<br />

has led managers to adopt<br />

enabling technologies. In the<br />

emerging ICTs environment, IT<br />

elements such as e-mail and group<br />

support facilities improve the<br />

coordination among the members<br />

<strong>of</strong> an organization in decision<br />

making. The use <strong>of</strong> these ICTs<br />

improves the organizational<br />

communication, which ultimately<br />

leads to effective decision-making<br />

(Rockart and Short, 1989).<br />

Furthermore ICTs are very useful<br />

means for collection and<br />

dissemination <strong>of</strong> information that<br />

is why most <strong>of</strong> the executives and<br />

the managers <strong>of</strong> private health<br />

organizations use e-mails<br />

frequently because they believe<br />

that ICTs can convey things more<br />

effectively Keri (2007).<br />

4. Conclusion<br />

Quick access to relevant and valid<br />

information is possible through<br />

information and communication<br />

technologies. Furthermore these<br />

new technologies provide<br />

information that is needed for<br />

better decision-making on the<br />

issues affecting an organization<br />

regarding human and material<br />

resources. Majority <strong>of</strong> the<br />

managers try to be rational while<br />

making decisions but to do so they<br />

must follow the steps <strong>of</strong> rational<br />

making process i.e. defining the<br />

problem situation, develop the<br />

alternatives, evaluate the<br />

alternatives and select the best one<br />

available and finally<br />

implementation and monitoring<br />

<strong>of</strong> the decision. In addition the<br />

‘development <strong>of</strong> the alternatives –<br />

phase’ <strong>of</strong> decision-making process<br />

will not be effective until the<br />

availability <strong>of</strong> timely and accurate<br />

information to analyze the<br />

decision situation and generate as<br />

many alternatives as possible too<br />

stresses the importance <strong>of</strong><br />

information and developing<br />

alternatives for effective<br />

decisions.<br />

References<br />

1. Adebayo, F.A. (2007). Management<br />

Information System for Managers.<br />

Ado-Ekiti: Green Line<br />

Publishers.<br />

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2. Agerfalk, P. J., Göran, G., Brian, F.<br />

and Liam, B. (2006). Reflecting<br />

on action in language,<br />

organizations and information<br />

systems. European <strong>Journal</strong> <strong>of</strong><br />

Information Systems (15): 4–8,<br />

[Available<br />

at:<br />

http://iet.ucdavis.edu/index.cf<br />

m].<br />

3. Ahlan, A.R. (2005). Information<br />

Technology Implementation:<br />

Managing IT Innovation in the<br />

Malaysian Banking Industry,<br />

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European Conference on IT<br />

Evaluation (ECITE), Turky,<br />

Finland.<br />

4. Andrew, G. and Michael, P. (2002).<br />

The role <strong>of</strong> health informatics in<br />

clinical audit: part <strong>of</strong> the<br />

problem or key to the solution?<br />

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20. Michel, A. and Betty, V. (2003)<br />

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organizations Volume 2 (1).<br />

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Concepts,<br />

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in the 1990s: Managing<br />

interdependence. Sloan<br />

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(2006). Fundamentals <strong>of</strong><br />

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Management, prentice hall.<br />

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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> Volume 1, Issue 1, October 2014: 21-30<br />

Original Paper<br />

Assessment Of Nutritionnal Status Of Hiv<br />

Infected And Hiv Negative Pregnant Women In<br />

Ngaoundere, Cameroon<br />

M Dangwe 1, 2 , C M Mb<strong>of</strong>ung 1<br />

1 Laboratory <strong>of</strong> Biophysics, food biochemistry and Nutrition<br />

2 Laboratory <strong>of</strong> Protestant hospital <strong>of</strong> Ngaoundere<br />

Background & objectives: Malnutrition (underfeeding) can affect the treatment <strong>of</strong> AIDS in<br />

that it reduces the ability <strong>of</strong> the intestine to absorb drugs, organic substances and<br />

micronutrients. Underfeeding could also increase the chances <strong>of</strong> transmission <strong>of</strong> the disease<br />

from an infected mother to the baby during pregnancy. The objective <strong>of</strong> this study is to<br />

compare the energy intake, weigh rate and nutritional status between the HIV and non HIV<br />

pregnant women attending two referrals hospitals in Ngaoundere (Cameroon).<br />

Methods:A cross sectional study using 24-hour dietary recall was applied to a sample <strong>of</strong> 109<br />

women, randomly selected from a population-based and anthropometric data were done.<br />

Results: Result show that HIV negative pregnant women consumed less energy intake per<br />

day than the HIV infected pregnant women at all age groups with no significant difference<br />

(F cal =1.19, p=0.317). Gain in weight between the HIV infected and HIV negative pregnant<br />

women in relation to their various age groups was no significant (F= 1.23, p=0.27). There was<br />

no significant influence <strong>of</strong> HIV status in pregnant women BMI (F=2 29, p=0.133).<br />

Interpretation & conclusion:In this study, the higher consumption <strong>of</strong> energy by HIV infected<br />

pregnant women than HIV negative women could be because HIV infected pregnant women<br />

were at the beginning <strong>of</strong> the infection which has not yet affected the immune system. In the<br />

two referral hospital <strong>of</strong> Ngaoundere besides HIV screening tests, should be also nutritional<br />

services to advice these women on their nutritional habits.<br />

Keywords: Malnutrition, Body mass Index, HIV/AIDS, energy consumption<br />

1. Introduction<br />

Acquired Immune Deficiency<br />

Syndrome (AIDS) is an<br />

infectious disease caused by the<br />

Human Immunodeficiency Virus<br />

(HIV) which appeared for the<br />

first time in the mid 1980 (BICE,<br />

1993). The Human<br />

Immunodeficiency Virus (HIV)<br />

reproduces in certain blood cells<br />

and more specifically in the white<br />

blood cells (WBC). The HIV<br />

thus attacks and weakens the<br />

immune system rendering the<br />

victim vulnerable to infections. It


<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 21-30 22<br />

has ravaged sub-Sahara Africa for<br />

decades and is still a major cause<br />

<strong>of</strong> adult morbidity and mortality<br />

(Masanjala, 2007). Recent<br />

estimates by the World Health<br />

Organization (WHO) show that<br />

about 33.3 million people are living<br />

with HIV/AIDS worldwide with<br />

22.5 million living in sub-Saharan<br />

Africa (Global Report, 2010). The<br />

prevalence in Cameroon stands at<br />

5.5 % with the Adamawa region<br />

occupying the 5 th position with 6.9<br />

% (Comité National de Lutte<br />

contre le Sida, 2004).<br />

Studies outlined that there<br />

is a relationship between<br />

malnutrition and AIDS (AIDS<br />

institute, 1995). Research shows<br />

that, the chance <strong>of</strong> infection with<br />

the HIV virus might be reduced<br />

in individuals who have good<br />

nutritional status with<br />

micronutrients and especially,<br />

vitamin A playing significant<br />

roles (ACC, 1998). Malnutrition<br />

(underfeeding) can affect the<br />

treatment <strong>of</strong> AIDS in that it<br />

reduces the ability <strong>of</strong> the<br />

intestines to absorb drugs, organic<br />

substances and micronutrients.<br />

Underfeeding could also increase<br />

the chances <strong>of</strong> transmission <strong>of</strong> the<br />

disease from an infected mother<br />

to the baby during pregnancy<br />

(Semba, 1997).<br />

This affirmation thus necessitates<br />

certain questions on the<br />

increasing rate <strong>of</strong> HIV positives<br />

in this region <strong>of</strong> the world, which<br />

is one <strong>of</strong> the most affected<br />

(CNLS, 2004). One would<br />

therefore be tempted to believe<br />

that underfeeding plays an<br />

important role in increasing the<br />

damaging effects <strong>of</strong> the<br />

HIV/AIDS. In the town <strong>of</strong><br />

Ngaoundere, there is a dearth <strong>of</strong><br />

informations on the relationship<br />

between underfeeding and<br />

HIV/AIDS. Thus, this study was<br />

undertaken to compare the energy<br />

intake, weight rate and nutritional<br />

status between the HIV and non-<br />

HIV pregnant women attending<br />

two referrals hospitals in<br />

Ngaoundere, Cameroon.<br />

2. Materials And Methods<br />

Study Area<br />

Ngaoundere is the capital city <strong>of</strong><br />

the Adamawa Region, Cameroon.<br />

The city is located at latitude<br />

7 0 .19’N and longitude 13 0 34’E. Its<br />

population was estimated at<br />

about 230,000 inhabitants in 2001<br />

(Tchotsoua, 2006).The Adamaoua<br />

region is high in altitude; its<br />

whether is between 22 and 25 0 .<br />

This plateau contains 2 types <strong>of</strong><br />

climates: the Sudanese type <strong>of</strong><br />

tropical climate and the<br />

Cameroon type <strong>of</strong> equatorial<br />

climate. The Sudanese type <strong>of</strong><br />

tropical climate has a dry season<br />

covering the period <strong>of</strong> November<br />

to March; then comes the moist<br />

season with down falls ranging<br />

from 900 mm to 1500mm. The<br />

©2014 <strong>Mediterranean</strong> Center <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong>


N. A. Qureshi et al 23<br />

Cameroon type <strong>of</strong> equatorial<br />

climate has a long dry season<br />

followed by a long rainy season.<br />

The down falls here range<br />

1500mm to 2000mm per year<br />

(Okouba and al., 2010).<br />

Study population and Design<br />

The study was cross-sectional in<br />

design. Pregnant women that<br />

attended antenatal services <strong>of</strong> the<br />

two referral hospitals in<br />

Ngaoundere (Protestant and<br />

Regional) were enrolled for the<br />

study. The study was conducted<br />

from May 2003 to January 2005. A<br />

total <strong>of</strong> 109 pregnant women at<br />

their third trimester were<br />

randomly selected and enrolled<br />

for the study. They were grouped<br />

into HIV infected (13) and non-<br />

HIV infected (96).<br />

Four age groups were ranged for<br />

the evaluation <strong>of</strong> age influence as<br />

a factor studied ( 27 years).<br />

Questionnaire Administration<br />

Questionnaires were administered<br />

to the women to collect data on:<br />

Age, level <strong>of</strong> education, number <strong>of</strong><br />

children, gravidity, preferred<br />

meals, family inherited illnesses,<br />

certain disease frequency in the<br />

family and pre-natal treatments.<br />

Nutritional feeding habits were<br />

obtained through interviews on<br />

the diets. A 24-hour dietary recall<br />

was applied to a sample <strong>of</strong><br />

women, randomly selected from a<br />

random population-based study<br />

sample. Most <strong>of</strong> the women had<br />

common feeding habits and their<br />

common meals were reported to<br />

be cereals (maize), tubers<br />

(cassava) and vegetables. The<br />

conversion <strong>of</strong> quantity consumed<br />

into calories was done with the<br />

help <strong>of</strong> a chart on food and<br />

nutritive value (FAO, 1968;<br />

Yadang, 2000).<br />

Assessment <strong>of</strong> nutritional status<br />

<strong>of</strong> the pregnant women<br />

Anthropometry is the<br />

measurement <strong>of</strong> human body. It is<br />

a quantitative method and is<br />

highly sensitive to nutritional<br />

status (Amuta and Houmsou,<br />

2009). The anthropometric<br />

factors: Weight (Kg) and Height<br />

(m) were used to calculate the<br />

Body Mass Index (BMI) as:<br />

()<br />

BMI =<br />

( )<br />

As the aforementioned formula<br />

reflects the human body without<br />

pregnancy, we subtracted the<br />

foetal weight from the total<br />

weight <strong>of</strong> the pregnant woman to<br />

get the exact BMI.<br />

We generally assume that a body<br />

mass index less than 18.5 implies<br />

that the woman is thin and<br />

between 18.5 and 25, we say the<br />

woman has a normal weight<br />

meanwhile values superior than 25<br />

indicates over weight (Gallagher<br />

and al.,2000).<br />

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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 21-30 24<br />

Statistical analysis<br />

Collected data were analyzed<br />

using Statgraphics 3.0. The one<br />

way ANOVA test was used to<br />

find significant difference<br />

between the means. The<br />

significance level was at p≤0.05<br />

level.<br />

3. Results<br />

Comparison <strong>of</strong> energy intake<br />

between HIV infected and HIV<br />

negative pregnant<br />

women in Ngaoundere,<br />

Cameroon<br />

The quantity <strong>of</strong> energy consumed<br />

by HIV negative pregnant women<br />

and HIV infected pregnant<br />

women is shown in Figure 1. The<br />

result shows that HIV negative<br />

pregnant women consumed less<br />

energy intake per day than the<br />

HIV infected pregnant women at<br />

all age groups with no significant<br />

difference (F cal =1.19, p=0.317).<br />

Variation in weight gain <strong>of</strong> HIV<br />

infected and HIV negative<br />

pregnant women.<br />

Studies and analysis <strong>of</strong> the weight<br />

parameter <strong>of</strong> HIV infected and<br />

HIV negative pregnant women<br />

showed that the daily weight gain<br />

by HIV negative pregnant women<br />

is 0,041 ± 0,029 kg/day , 0.042 ±<br />

0,033 kg/day; 0,054 ± 0,047 kg/day;<br />

0,057 ±0.06 kg/day for group I, II,<br />

III and IV respectively,<br />

meanwhile for HIV infected<br />

women it is 0.038 ± 0.023kg/day;<br />

0.039 ± 0.014kg/day; 0,044 ±<br />

0,012kg/day; 0,017 ± 0.037 kg/day<br />

for group I, II, III and IV<br />

respectively (Figure 2). No<br />

significance difference was<br />

observed in weight gain between<br />

the HIV infected and HIV<br />

negative pregnant women in<br />

relation to their various age<br />

groups (F= 1.23, p=0.27).<br />

Body Mass Index (BMI) <strong>of</strong> HIV<br />

infected and HIV negative<br />

pregnant women<br />

The body mass index <strong>of</strong> HIV<br />

infected and HIV negative<br />

pregnant women is shown in<br />

Figure 3. It is observed that HIV<br />

status does not influence pregnant<br />

women BMI (F=2 29, p=0.133).<br />

Pregnant women were grouped<br />

into 3 depending on their Body<br />

Mass Index (Table 1). Results<br />

showed that 0,92% <strong>of</strong> the HIV<br />

infected pregnant women are<br />

underweight , 7,34% are <strong>of</strong><br />

normal size, and 3,67% are<br />

overweight, while 0.92% <strong>of</strong> the<br />

negative were <strong>of</strong> underweight<br />

46,79%are <strong>of</strong> normal size, and<br />

40,36% are overweight. Although<br />

according to the body mass index<br />

<strong>of</strong> women at the start <strong>of</strong><br />

pregnancy, 18.34% are thin and<br />

81.65% normal.<br />

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N. A. Qureshi et al 25<br />

Table 1: Percentages on the Body Mass Index <strong>of</strong> HIV infected and HIV negative pregnant<br />

women in relation to their age group.<br />

Number<br />

BMI (Kg/m 2 ) HIV positive (%) HIV Negative (%)<br />

Underweight (< 18.5) 1 (0,92) 1 (0,92)<br />

Normal weight (18.5-25) 8 (7,34) 51 (46,79)<br />

Overweight (˃ 25) 4 (3,67) 44 (40,36)<br />

4000<br />

3500<br />

3000<br />

2500<br />

Energy (Kcal/J)<br />

2000<br />

1500<br />

1000<br />

500<br />

HIV negative pregnant women<br />

HIV infected pregnant women<br />

0<br />

< 19 19-22 23-26 27-35<br />

(Years)<br />

Fig1: Comparison <strong>of</strong> energy intake between HIV infected and HIV negative<br />

pregnant women in relation to age.<br />

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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 21-30 26<br />

120<br />

100<br />

HIV negative pregnant women<br />

HIV infected pregnant women<br />

80<br />

weight *10 -3 (kg)<br />

60<br />

40<br />

20<br />

0<br />


N. A. Qureshi et al 27<br />

4. Discussion<br />

Generally, the energy intake by<br />

HIV infected pregnant women<br />

appears to be higher than that <strong>of</strong><br />

HIV negative pregnant women.<br />

This could be because HIV<br />

infected pregnant women were at<br />

the beginning <strong>of</strong> the infection<br />

which has not yet affected the<br />

immune system. It could be also<br />

due to the fact that there were not<br />

aware <strong>of</strong> their HIV status which<br />

could have affected their mind<br />

therefore influencing them to lose<br />

weight through their thoughts. A<br />

study reported that the quantity<br />

<strong>of</strong> energy necessary for pregnant<br />

women <strong>of</strong> the third trimester is<br />

2,250 kcal per day. However, a<br />

comparison <strong>of</strong> the energy taken by<br />

the HIV negative and HIV<br />

infected pregnant women in this<br />

study revealed that the energy<br />

levels were higher than values<br />

reported by Dupin and al<br />

(1992).This could be justified by<br />

the fact that these pregnant<br />

women were in the third trimester<br />

<strong>of</strong> pregnancy when they have the<br />

tendency <strong>of</strong> eating a lot<br />

irrespective <strong>of</strong> their HIV status.<br />

In our study group, we noticed<br />

that infected pregnant women and<br />

non infected pregnant women<br />

gain weight during pregnancy.<br />

We observe that the biggest mean<br />

rates <strong>of</strong> gain for 3 rd trimester <strong>of</strong><br />

pregnancy in our population<br />

group is 0,399kg/wk for HIV<br />

negative pregnant women and<br />

0,308 kg/wk for HIV infected<br />

pregnant women. The presumably<br />

gain weight from HIV-uninfected<br />

adult women from the United<br />

States and Europe are 0,30 to 0,54<br />

kg/wk during the 3 rd trimester.<br />

However, people on whom we<br />

worked have weight ranges these<br />

values. This result is similar to<br />

those reported by Strauss and al.<br />

(1999) and Ladner and al (1998),<br />

but contrasts that <strong>of</strong> Kim and al.<br />

(1996) who observed HIV<br />

infected subjects to be suffering<br />

from underfeeding and weight<br />

lost at the onset <strong>of</strong> the infection.<br />

The difference between our study<br />

and that observed by Kim et al.<br />

(1996) is that the subjects enrolled<br />

in our study were found to have<br />

more energy intake than the<br />

recommended<br />

energy<br />

consumption. The energy surplus<br />

consumed by these pregnant<br />

women would have compensated<br />

the expected weight. We did not<br />

find further evidence in the<br />

literature that suggested<br />

differences in the pattern <strong>of</strong><br />

weight gain by HIV status. But<br />

we know that lean body mass loss<br />

can be improved when nutrition<br />

counseling is combined with<br />

nutritional interventions (Stack<br />

and al.,1996). The body mass index<br />

observed in our study show that<br />

HIV status does not influence the<br />

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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 21-30 22<br />

weight gain by pregnant women.<br />

This result is similar with studies<br />

reported in Tanzania who find<br />

that there is not significant<br />

difference between body mass<br />

index infected and HIV-negative<br />

women (Villamor and al., 2004).<br />

This could be justified by the fact<br />

that these infected women are at<br />

the beginning <strong>of</strong> their illness.<br />

5. Conclusion<br />

Our study report that, no<br />

significant difference was<br />

observed between HIV infected<br />

and HIV negative pregnant<br />

women with regards to energy<br />

intake and weight gain. Our<br />

results also showed that age<br />

groups and HIV status had no<br />

significant influence on the<br />

pregnant women’s Body Mass<br />

Index. Besides HIV screenings<br />

test, were done to the women<br />

attending their antenatal services<br />

in there should be also nutritional<br />

services to advice these women on<br />

their nutritional habits.<br />

Acknowledgements<br />

The authors thank the<br />

pregnant women that attended the<br />

regional and protestant hospitals<br />

<strong>of</strong> the Adamaoua region for their<br />

kindness and collaboration which<br />

allowed successful data collection.<br />

The nurses <strong>of</strong> antenatal services<br />

both hospitals are also<br />

acknowledged.<br />

References<br />

1. ACC/SCN. 1998. Overview to feature:<br />

Nutrition and HIV/AIDS.<br />

SCN News, 17:3-4.<br />

2. AIDS INSTITUTE.,1995. Nutrition in<br />

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Health, Tufts University School<br />

<strong>of</strong> Medicine, Boston.<br />

11. Ladner, J., Castetbon, K., Leroy, V.,<br />

Nyiraziraje, M., Chauliac, M.,<br />

Karita, E., De Clercq, A., Van de<br />

Perre, P. & Dabis, F. (1998).<br />

Pregnancy, body weight and human<br />

immunodeficiency virus infection in<br />

African women: a prospective<br />

cohort study in Kigali (Rwanda),<br />

1992–1994. Int. J. Epidemiol.<br />

27:1072-1077.<br />

12. Masanjala, W., 2007. The poverty-<br />

HIV/AIDS nexus in Africa: A<br />

livelihood approach. Social Science<br />

et Medicine, 64 (5): 1032-1041.<br />

13. Okouba Barnabe ; Ambroise Abanda ;<br />

Tchomthe séverin ., 2010. Rapport<br />

Régional des Progrès des objectifs<br />

du millénaire pour le<br />

développement. Région de<br />

l’Adamaoua. Sous la coordination<br />

de l’Institut National de la<br />

statistique du Cameroun avec<br />

l’appui du PNUD. Ministère de<br />

l’Economie de la Planification et de<br />

l’Aménagement du Territoire.<br />

14. Semba R D., 1997.Overview <strong>of</strong> the<br />

potential role <strong>of</strong> vitamin A in<br />

mother-to child transmission <strong>of</strong><br />

HIV-1. Acta paediatr suppl<br />

421:107-112.<br />

15. Sibetcheu, D; Nanka, P. M; Tatat , J;<br />

Ngoh,G. M.M; Hakoua, A.,<br />

2000. Enquêtes Nationales sur la<br />

carence en vitamines A et<br />

l’anémie au Cameroun.<br />

16. Statgraphics plus 3.0 (1994).<br />

Statgraphics for windows<br />

version release 3.0.<br />

17. Strauss, R. S. & Dietz, W. H. (1999).<br />

Low maternal weight gain in the<br />

second or third trimester<br />

increases the risk for<br />

intrauterine growth retardation.<br />

J. Nutr. 129:988-993.<br />

18. Tchotsoua (2006). Evolution<br />

récente des territoires de<br />

l’Adamawa central: de la<br />

spatialisation à l’aide pour un<br />

développement maîtrisé.<br />

Université d’Orléans. Ecole<br />

doctorale sciences de l’homme<br />

et de la société. HDR.<br />

Discipline (Géographie<br />

Aménagement-Environnement).<br />

p 267.<br />

19. Villamor Eduardo; Michele L.<br />

Dreyfuss; Ana Baylín * ; Gernard<br />

Msamanga; Wafaie W. Fawzi *<br />

(2004). Weight loss during<br />

pregnancy is associated with<br />

adverse pregnancy outcomes<br />

among HIV-1 infected women<br />

The American Society for<br />

Nutritional <strong>Sciences</strong>.<br />

20. Yadang, 2000. Etude de la valeur<br />

nutritive de quelques mets de<br />

l’Extrême-Nord Cameroun.<br />

Mémoire soutenue en vu de<br />

l’obtention de la Maitrise en<br />

Biologie<br />

Appliquée.<br />

Département des sciences<br />

Biologiques. Université de<br />

Ngaoundere.<br />

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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> Volume 1, Issue 1, October 2014: 31-52<br />

Original Paper<br />

Issues and Prospects <strong>of</strong> e-health in Pakistan<br />

Qamar Afaq Qureshi 1 , Najam Afaq Qureshi 2 , , Dr. Muhammad Zubair<br />

Khan 2 , Dr. Allah Nawaz 1 Dr. Bahadar Shah 3 ,<br />

1 Gomal University, Pakistan 2 Sarhad University, Pakistan, , 3 Hazara University, Pakistan<br />

Abstract<br />

Background & objectives: In connection with access to information in developing countries,<br />

information flows through existing networks <strong>of</strong> communication is a main theme in the current<br />

IS literature .<br />

Methods:Information-intensive infrastructure is a requirement for information dissemination<br />

due to the shortage <strong>of</strong> network infrastructure in the majority <strong>of</strong> developing states. It is<br />

verified by many researchers that information managing technologies with their main purpose<br />

<strong>of</strong> ‘handling information’ have the advantage to enhance already existing technologies by<br />

making better information-communication a priori to new ICT innovations .Presently health<br />

information system infrastructure is deficient in resources to meet the demands and needs <strong>of</strong><br />

increasing population in developing countries. Health care systems <strong>of</strong> developing countries<br />

have major barriers like poverty and lack <strong>of</strong> technological sophistication.<br />

Results:The basic difficulties or barriers in using information technologies include poor or<br />

inadequate infrastructure, insufficient access to the hardware and inadequate or poor<br />

resources allocation. By eliminating these barriers population health status can be improved in<br />

developing countries.<br />

Interpretation & conclusion: This study aims to determine the main issues and prospects for e-<br />

health in the current situation <strong>of</strong> developing countries like Pakistan and the way forward for<br />

policy makers to manage all issues in future for more effective and rational decision-making<br />

in healthcare organizations.<br />

Key words: e-health; challenges; prospects; developing countries; Pakistan<br />

1. Introduction<br />

E–health is a latest platform for<br />

handling many healthcare issues.<br />

E-health systems have presented<br />

so many gadgets which are being<br />

used by both developed and<br />

developing states. Healthcare<br />

related IS and hardware is now<br />

inexpensively obtainable all over<br />

the world. On the other hand<br />

successful adoption and use <strong>of</strong> e-<br />

health systems depends on the<br />

suitable infrastructure (Khoja et<br />

al., 2012). The readiness and<br />

awareness <strong>of</strong> doctors and<br />

physicians about the usage <strong>of</strong> ITapplications<br />

in hospitals can be


<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 31-52 32<br />

developed and maintained by<br />

providing proper tools and devices<br />

and proper training on regular<br />

intervals for more rapid access to<br />

information on internet. For<br />

handling users- related issues and<br />

maintaining regular use <strong>of</strong> ICTs<br />

in health organizations, healthcare<br />

providers must be given<br />

opportunity to take part in<br />

information systems development<br />

process and include the IScontents<br />

according to their<br />

requirements (Rezai-Rad et al.,<br />

2012).<br />

Concentrating on informationcentered<br />

ICT applications in<br />

developing countries is<br />

comparatively a new sphere and<br />

subject in the domain <strong>of</strong> health<br />

informatics (Kimaro & Titlestad,<br />

2008). Sound evidence-based<br />

literature extracted on influence<br />

assessments or outcome<br />

measurements is still lacking<br />

regarding ICTs-applications in<br />

the healthcare sector (Rezai-Rad<br />

et al., 2012). Published evidences<br />

are presently available on this<br />

topic and are at pilot or the pro<strong>of</strong><strong>of</strong>-concept<br />

stage. In many cases,<br />

the statements are not individual<br />

analyses, rather are based on<br />

collective skills and practices,<br />

consensus statements, and policies<br />

(Soar et al., 2012).<br />

The significance <strong>of</strong> the concepts<br />

<strong>of</strong> ‘information’, ‘information<br />

first’ has been advocated by many<br />

IS researchers for the successful<br />

adoption and use <strong>of</strong> the ITapplications<br />

in any organization<br />

and involvement towards the<br />

‘information-centered ICT’<br />

concept is a major example<br />

(Nyella & Mndeme, 2010).<br />

Furthermore the ICT-applications<br />

may only bring small direct<br />

benefits for poverty alleviation<br />

and the possibility for ICTapplications<br />

depends on both<br />

financial and access to cultural,<br />

political and educational<br />

resources. And finally, the access<br />

to social assets and increasing<br />

confidence and support through<br />

locally contextualized social<br />

networks built through<br />

community-based initiatives is<br />

more crucial than looking for<br />

access to new information from<br />

digital ICTs (Khoja et al.,2012).<br />

Many studies reveal that doctors<br />

and physicians in developing<br />

countries are not given an<br />

opportunity to be take part in<br />

information system development<br />

process, consequently IS/ICTs do<br />

not possess the features which are<br />

according to the needs <strong>of</strong><br />

healthcare providers (Rezai-Rad et<br />

al., 2012).Although e-health<br />

systems in developing countries is<br />

not a new concept any longer but<br />

there is sluggish usage <strong>of</strong> internet<br />

among healthcare providers due to<br />

lack <strong>of</strong> the capability to read, be<br />

©2014 <strong>Mediterranean</strong> Center <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong>


Q. A. Qureshi et al. 33<br />

aware <strong>of</strong> and use a variety <strong>of</strong><br />

technical terms on<br />

internet(Hogan<br />

&<br />

Palmer,2005).Furthermore the<br />

little use <strong>of</strong> internet among<br />

healthcare pr<strong>of</strong>essionals <strong>of</strong><br />

developing nations like Pakistan<br />

is mostly because <strong>of</strong> improper<br />

tools and devices and shortage <strong>of</strong><br />

proper training programs<br />

regarding eHealth systems(Malik<br />

et al., 2008).<br />

Doctors and physicians in<br />

developing countries complaint<br />

that IS and particularly the<br />

interfaces are not user friendly. In<br />

addition IT- applications in<br />

healthcare sector are inflexible in<br />

nature consequently create users’<br />

related problems .The s<strong>of</strong>tware in<br />

the hospitals <strong>of</strong> developing<br />

countries do not have the contents<br />

in native languages regarding e-<br />

health systems (Chetley,2006). E-<br />

health projects in developing<br />

countries generally unsuccessful<br />

due to a shortage <strong>of</strong> ITpr<strong>of</strong>essionals<br />

and their knowledge<br />

and expertise in e-health systems<br />

(Kimaro & Nhampossa, 2005). ITpr<strong>of</strong>essionals<br />

require training and<br />

education in order to effectively<br />

use all e-health applications<br />

.Training should be a frequent<br />

feature and healthcare<br />

pr<strong>of</strong>essional must be given the<br />

training at least once a year (Qazi<br />

& Ali, 2009).<br />

2. e-Health in Pakistan<br />

In all bad surroundings and<br />

situations, Pakistan is making its<br />

efforts for the war on terror and<br />

people <strong>of</strong> the country are facing<br />

many challenges and even die in<br />

this war in bomb blasts.<br />

Healthcare system is a<br />

requirement for developing<br />

countries like Pakistan. At<br />

present, in Pakistan near about<br />

seventy five percent <strong>of</strong> population<br />

resides in rural areas where road<br />

and transport facilities are<br />

inadequate, shortage <strong>of</strong> healthcare<br />

providers in rural areas,<br />

pr<strong>of</strong>essional physicians and<br />

surgeons are least interested to go<br />

in far flung areas because <strong>of</strong> poor<br />

infrastructure, patients being<br />

carried on their own way to arrive<br />

at the city hospital for an instant<br />

healthcare or diagnoses which<br />

could have without difficulty been<br />

treated at their own locations<br />

provided medical consultations<br />

are available (Saleem, 2010). The<br />

majority <strong>of</strong> cities in Pakistan<br />

facilitate telecommunications<br />

links, more than 1800 cities <strong>of</strong><br />

Pakistan have access to 531,787<br />

broadband connections and 400<br />

cities are on Fiber Optic, giving<br />

possibility to access universal<br />

health<br />

information.<br />

Implementation <strong>of</strong> any<br />

information system at the start is<br />

not up to the mark but it will also<br />

provide solutions usually in<br />

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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 31-52 34<br />

emergency situations (Ansari et<br />

al.,2012).<br />

There has been an explosion in<br />

knowledge and information<br />

management activity, mainly in<br />

healthcare sector over the<br />

previous few years. By and large,<br />

hospitals and medical schools<br />

have started using the services <strong>of</strong><br />

doctors who possess computer and<br />

computerization skills. These<br />

organizations have also obtained<br />

complicated information systems<br />

to collect and retrieve<br />

accumulated knowledge. Ehealth<br />

system includes many elements<br />

such as telemedicine, teleeducation,<br />

telematics for better<br />

management <strong>of</strong> healthcare and<br />

research (Kijsanayotin ,<br />

Kasitipradith & Pannarunothai<br />

,2010). There are four areas where<br />

health informatics is performing<br />

an escalating role in healthcare<br />

development: a) administrative,<br />

b) education and training, c)<br />

quality improvement and d) the<br />

recovery <strong>of</strong> efficiency <strong>of</strong> health<br />

care services (Bhutto et al., 2010).<br />

In Pakistan 72% <strong>of</strong> population<br />

lives in rural areas and 28% <strong>of</strong><br />

population lives in urban areas.<br />

Condition <strong>of</strong> health can be<br />

determined effortlessly from the<br />

reality that there are 74 physicians<br />

per 100,000 persons in early 2000s.<br />

There are several rural areas<br />

where people have not seen a<br />

capable and skilled health<br />

pr<strong>of</strong>essional in their entire life<br />

(Bhutto et al., 2010). The<br />

municipal areas <strong>of</strong> Sindh are well<br />

equipped with health facilities;<br />

which are not enough for huge<br />

population but facilities are there,<br />

whereas rural Sindh does not have<br />

well equipped health facilities.<br />

Available possessions at urban<br />

areas can be shared as well as<br />

expanded to the rural areas with<br />

the help <strong>of</strong> digital connectivity.<br />

Particularly, Karachi capital city<br />

<strong>of</strong> Sindh holds very latest<br />

healthcare facilities (Durrani et<br />

al., 2012).<br />

In urgent cases where instant<br />

medical treatment is very vital,<br />

current studies reveal that before<br />

time and particular pre-hospital<br />

patient management leads to the<br />

patient’s survival. Especially in<br />

cases <strong>of</strong> serious head injuries,<br />

spinal cord or internal organs<br />

damage and pain, the way the<br />

events are treated and transported<br />

is critical for the forthcoming<br />

well-being <strong>of</strong> the patients<br />

.Bringing improvements in<br />

healthcare services and remain fit<br />

and healthy is one <strong>of</strong> the most<br />

discussed and key issues in our<br />

society. The acceptance <strong>of</strong> ITapplications<br />

in healthcare sector<br />

have very solid and successful<br />

attempt for the provision <strong>of</strong><br />

improved healthcare services<br />

(Malik et al., 2008). But constant<br />

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Q. A. Qureshi et al. 35<br />

guidelines must be developed and<br />

agreed across the board in<br />

connection with the processing <strong>of</strong><br />

health-related data, with<br />

particular explanations regarding<br />

diagnostic notes, which stress and<br />

assure its protection and<br />

confidentiality, as well as free and<br />

open access, by the patients to<br />

their own data. Furthermore the<br />

potential technical knowledge<br />

difficulties can be neutralized by<br />

making sure that the ITapplication<br />

is both technically<br />

possible and clinically suitable. In<br />

addition to that all citizens,<br />

doctors & physicians and policy<br />

makers must acknowledge and<br />

appreciate the adoption and use <strong>of</strong><br />

eHealth systems (Bhutto et al.,<br />

2010).<br />

The significance <strong>of</strong> a health<br />

information system (HMIS)<br />

cannot be neglected in a country<br />

like Pakistan because health<br />

policies and planning in any<br />

country generally depend on the<br />

accurate and well-timed<br />

information on various health<br />

issues (Ali & Horikoshi, 2002). In<br />

Pakistan, before the 1990s, a<br />

number <strong>of</strong> vertical programs with<br />

categorical disease-specific<br />

information systems ended in<br />

disorganized data transmission,<br />

which made evaluation <strong>of</strong><br />

program usefulness difficult for<br />

managers. In 1991-92, the Ministry<br />

<strong>of</strong> Health (MoH) started an<br />

assessment study <strong>of</strong> existing HIS<br />

and transformed the reporting<br />

systems into a comprehensive<br />

National HMIS through a<br />

consultative procedure (Qazi &<br />

Ali, 2004). However, there is need<br />

to develop integrated disease close<br />

watch infrastructure and technical<br />

competence in tropical countries<br />

on the reporting and scientific<br />

evidence necessities <strong>of</strong> the<br />

sanitary agreement under the<br />

WTO (Singer & deCastro, 2007).<br />

Health information is<br />

information about people’s health<br />

and what they, government, and<br />

others are doing about it. It<br />

explains the occurrence,<br />

frequency, and reasons <strong>of</strong> major<br />

diseases, as well as accessibility<br />

and efficiency <strong>of</strong> curative<br />

activities (Ali & Horikoshi, 2002;<br />

Khalid et al.,2008). Under the<br />

transfer <strong>of</strong> power initiative,<br />

Pakistan's MoH has advocated<br />

strengthening <strong>of</strong> health<br />

information systems for more<br />

informed decision-making in<br />

planning, managing, checking and<br />

control <strong>of</strong> healthcare services for<br />

improved service delivery in the<br />

districts. However, the efforts at<br />

increasing information systems<br />

have generally proved<br />

unproductive and sometimes<br />

counterproductive. Analyses <strong>of</strong><br />

the malfunctioning <strong>of</strong>ten fail to<br />

notice the perceptions <strong>of</strong><br />

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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 31-52 36<br />

stakeholders as an important<br />

factor (Ansari et al., 2012).<br />

Given the large health<br />

infrastructure in Pakistan both<br />

public and private, supplying to a<br />

population <strong>of</strong> 137 million people,<br />

there had been a need to build up<br />

and start a national health<br />

management information system<br />

which is able to collect, process,<br />

analyze and provide criticism on<br />

all health related data including<br />

information on input, process and<br />

output indicators (Gururajan et<br />

al.,2008). The national feedback<br />

reports on the new HMIS admit a<br />

slow development in scope and<br />

reporting reliability, but also note<br />

the continued need for<br />

improvement in the quality and<br />

usage <strong>of</strong> information at various<br />

levels. A study carried out in 2000<br />

pointed out that the information<br />

produced via HMIS was unrelated<br />

and the data did not help<br />

managers to make decisions<br />

(Bhutto et al., 2010).<br />

Ministries <strong>of</strong> Health are<br />

approving Computer S<strong>of</strong>tware in<br />

order to get better health data<br />

collection, stretch, storage,<br />

analysis and distribution in their<br />

Health Information Systems<br />

(Khoja et al., 2008). Computer<br />

s<strong>of</strong>tware are obtained through<br />

various means including buying<br />

on-shelf s<strong>of</strong>tware, indenture based<br />

s<strong>of</strong>tware, and donated s<strong>of</strong>tware.<br />

Most <strong>of</strong> the S<strong>of</strong>tware acquired<br />

through these means is not<br />

distributed with their source codes<br />

in that they are proprietary<br />

s<strong>of</strong>tware. However, the data<br />

elements <strong>of</strong> Health Information<br />

Systems are changing regularly<br />

due to changing disease patterns;<br />

incoming and outdated drugs, and<br />

changing health policies (Ishtiaq<br />

et al., 2012).<br />

As s<strong>of</strong>tware requires to be redesigned<br />

from time to time to take<br />

on changing requirements arises<br />

there is a need to think about<br />

efforts on open source s<strong>of</strong>tware.<br />

With Open Source S<strong>of</strong>tware<br />

development method, the<br />

s<strong>of</strong>tware is distributed with their<br />

source code which means that a<br />

Ministry <strong>of</strong> Health can uphold its<br />

s<strong>of</strong>tware with no unique<br />

developers (Mostafa et al., 2011).<br />

The characteristics <strong>of</strong> Open<br />

Source S<strong>of</strong>tware development<br />

approaches seems to be<br />

appropriate in developing<br />

s<strong>of</strong>tware for Health Information<br />

System in that health information<br />

systems institutions has full<br />

access to their s<strong>of</strong>tware source<br />

codes and thus can bring in any<br />

changes according to their<br />

requirements instantly. In the<br />

case, the Ministry has no ICT<br />

capacity (say human resources) to<br />

be able to change the s<strong>of</strong>tware; the<br />

s<strong>of</strong>tware can be restructured by<br />

any computer expert and not<br />

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Q. A. Qureshi et al. 37<br />

necessarily the ones who have<br />

developed that s<strong>of</strong>tware (Durrani<br />

et al., 2012).<br />

3. Issues & Prospects<br />

Pakistan health services and<br />

health signs are usually poor<br />

especially in the far flung and<br />

rural areas. Out <strong>of</strong> 1000 infants<br />

76.6 persons <strong>of</strong> them die and the<br />

death rate under age 5 is 10.1 %.<br />

Malaria occurrence is 0.75 per 1000<br />

persons, whereas, TB incidence is<br />

181 persons per 100,000. The health<br />

expenses have been very low and<br />

not adequate to give good health<br />

to people. For example the<br />

development spending was Rs.<br />

14.272 billion for the year 2007-08,<br />

and the recent expenditure was.<br />

Rs. 3.791 billion. Improved health<br />

enhances the output <strong>of</strong> the labor<br />

force, strengthens their economic<br />

conditions and eventually enables<br />

them to lead a superior life. To<br />

achieve better, competent,<br />

effective and industrious<br />

workforce, governments promote<br />

the healthcare services. Moreover<br />

the present state <strong>of</strong> affairs <strong>of</strong> the<br />

human resource, a small<br />

adjustment in public sector<br />

expenses on healthcare services<br />

can have a strong influence on the<br />

workforce and thus the economic<br />

development.<br />

E-Health is slowly but surely<br />

becoming popular throughout the<br />

world. This is ordinary and the<br />

routine in the developed countries<br />

but developing nations are so far<br />

initializing to implement and use<br />

eHealth systems for better<br />

healthcare services (Sarkar, 2008).<br />

The appearance and advent <strong>of</strong><br />

IS/ICTs have opened new views<br />

for the countries to handle their<br />

problems consequently the<br />

developing countries are also<br />

making efforts to implement these<br />

tools and gadgets. On the other<br />

hand, there are several difficulties<br />

and barriers which needs to be<br />

removed away prior to taking full<br />

benefits <strong>of</strong> IT-applications for<br />

healthcare (Chanda & Shaw,<br />

2010).<br />

E-Health is the adoption and use<br />

<strong>of</strong> ICTs that includes the internet<br />

for more improved and better<br />

delivery <strong>of</strong> healthcare services<br />

(Eng, 2001). Another writer<br />

remarks that e-Health is a new<br />

and very potential subject and<br />

field <strong>of</strong> medical informatics,<br />

referring to the organization and<br />

delivery <strong>of</strong> healthcare services and<br />

information using the Internet<br />

and interrelated technologies<br />

(Pagliari et al., 2005). It is also<br />

noteworthy that the majority <strong>of</strong><br />

the studies about eHealth and its<br />

successful adoption and use have<br />

been carried-out in both developed<br />

(Eysenbach, 2001; Alvarez, 2004;<br />

Pagliari et al., 2005) and<br />

developing states (Mosse & Sahay<br />

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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 31-52 38<br />

2003; Braa et al.2004; Chanda&<br />

Shaw, 2010).<br />

A number <strong>of</strong> aspects and features<br />

have been exposed as the crucial<br />

factors in creating or destroying<br />

the functions and tasks <strong>of</strong> e-<br />

Health system everywhere.<br />

Though, the research indicates<br />

that ‘top-management-support’<br />

and ‘government-ePolicies’ play<br />

leading role in all the matters<br />

concerning to the planning,<br />

development, adoption and use <strong>of</strong><br />

new ehealth systems along with<br />

their maintenance on continual<br />

basis(Scott et al., 2002). This<br />

becomes extremely important in<br />

case <strong>of</strong> the developing countries<br />

like Pakistan. The developing<br />

nations have extra issues <strong>of</strong><br />

‘digital-literacy’ <strong>of</strong> all the<br />

government authorities,<br />

developers <strong>of</strong> the systems and<br />

definitely the future users <strong>of</strong><br />

ehealth applications (Lang &<br />

Mertes, 2011).<br />

It is not just the willingness and<br />

acceptability <strong>of</strong> the all the<br />

expected users in an organization<br />

which controls and decides the<br />

success and failure <strong>of</strong> the e-Health<br />

initiatives rather it also contains<br />

the approach and stance <strong>of</strong><br />

government (external authority)<br />

as well as the top management <strong>of</strong><br />

the organization (internal<br />

executives) (Kimaro &<br />

Nhampossa,2007). Keeping in<br />

view the specified responsibility<br />

and function <strong>of</strong> top management,<br />

it is not unexpected that the<br />

interest and support <strong>of</strong> the<br />

executives in an organization has<br />

been one <strong>of</strong> the most generally<br />

talked-about organizational<br />

factors for the successful<br />

implementation <strong>of</strong> eHealth<br />

projects (Hussein et al., 2007).A<br />

lot <strong>of</strong> studies on the role <strong>of</strong> top<br />

management support for the<br />

success <strong>of</strong> e-health systems have<br />

been conducted (Sajjad et al., 2009;<br />

Qaisar & Khan, 2010).<br />

E-Health policy is fastened with<br />

the availability <strong>of</strong> resources along<br />

with the pr<strong>of</strong>essionalism is needed<br />

for the proper utilization <strong>of</strong> the<br />

resources, implementing plans<br />

and receiving the results. Lack <strong>of</strong><br />

pr<strong>of</strong>essional frame <strong>of</strong> mind and<br />

the attitude is apparently the<br />

bigger concern and matter for<br />

those developing states which<br />

have the resources (Scott et al.,<br />

2005).Government eHealth<br />

policies make an environment<br />

where the likelihood <strong>of</strong> using<br />

resources effectively is increased,<br />

the pr<strong>of</strong>essionals find their<br />

suitable places and exercise<br />

faithfully and the future <strong>of</strong> ITapplication<br />

in healthcare becomes<br />

clearly identifiable (Shaqrah,<br />

2010).<br />

In spite <strong>of</strong> the abilities and<br />

benefits <strong>of</strong> e-Health and<br />

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Q. A. Qureshi et al. 39<br />

Telemedicine for sustainability <strong>of</strong><br />

eHealth systems, some barriers, at<br />

different levels, are required to be<br />

overcome for health systems to<br />

take full advantage <strong>of</strong> these<br />

opportunities. These barriers are<br />

not<br />

uni-dimensional,<br />

concentrating on technical<br />

knowledge as assumed in the past,<br />

but somewhat a multidimensional<br />

concept, surrounding technical<br />

knowledge, economic feasibility,<br />

organizational support and<br />

behavior adaptation. The<br />

Telemedicine Alliance, a<br />

collaboration between the World<br />

Health Organization, the<br />

European Space Agency and the<br />

International<br />

Telecommunications Union<br />

studied e-Health and<br />

Telemedicine adoption trends<br />

through personal interviews with<br />

54 European telecommunications<br />

experts, health policy makers, and<br />

healthcare providers (Rhidian, &<br />

Hughes 2003).<br />

3.1 Specific Issues <strong>of</strong> Developing<br />

States like Pakistan<br />

These Issues <strong>of</strong> Developing States<br />

are divided into following groups:<br />

1. National Policies towards<br />

HIT: Efficient, effective and<br />

secure national policy can address<br />

the local health needs according to<br />

the changing environment is<br />

needed. These policies can be<br />

devised by policy makers and<br />

practitioners to assess and<br />

implement research evidences.<br />

Enforcing the legislation is<br />

difficult in developing countries<br />

and acceptance by the community<br />

for the transformation <strong>of</strong> any<br />

system is hard.<br />

2. Poor eHealthcare design:<br />

Many e-healthcare systems are<br />

developed by Information<br />

Technology (IT) solution<br />

companies which operate for the<br />

purpose <strong>of</strong> getting pr<strong>of</strong>it. These<br />

companies are interested with the<br />

financial gain from e-healthcare<br />

products that they produce. They<br />

concentrate much in producing<br />

usable products for healthcare<br />

institutions and hence causing<br />

privacy, security and<br />

confidentiality to suffer. In order<br />

to resolve this, efforts to secure e-<br />

healthcare systems need to be<br />

taken from design <strong>of</strong> the systems<br />

to implementation in order for the<br />

developments that have been<br />

achieved so far to be rolled to the<br />

real world.<br />

3. Organizational Barriers:<br />

Organizations and people play a<br />

very critical role in implementing<br />

and transformation <strong>of</strong> an<br />

information system. First <strong>of</strong> all<br />

there are no documented studies<br />

available regarding level and use,<br />

benefits, cost, risk analysis and<br />

other aspects <strong>of</strong> health technology<br />

in health sector <strong>of</strong> underdeveloped<br />

countries and if they are available<br />

for the developing countries they<br />

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are not well communicated.<br />

Secondly, people at higher<br />

positions and posts, whose needs<br />

<strong>of</strong> reporting are adequately being<br />

catered by the existing system, do<br />

not favor HIT as they think that<br />

the employment <strong>of</strong> new<br />

technology is wastage <strong>of</strong> both the<br />

money and time. Hospitals must<br />

address the apprehension <strong>of</strong><br />

physicians because if by using<br />

HIT their pr<strong>of</strong>essional<br />

responsibilities become difficult<br />

they will never support its use.<br />

4. Social and Cultural<br />

Barriers: Digital divide and e-<br />

readiness are major social and<br />

cultural barriers in establishment<br />

and use <strong>of</strong> health information<br />

system. These barriers include<br />

lack <strong>of</strong> stakeholder’s interest, less<br />

motivation, anxiety to adapt and<br />

use new technology. Health care<br />

personnel are difficult to convince<br />

for use <strong>of</strong> new health<br />

technologies. As they are more<br />

comfortable with their<br />

conventional approach and<br />

routine practice so it is<br />

complicated to transform health<br />

information system from paper<br />

based to digital format (Durrani et<br />

al., 2012).<br />

5. Infrastructure-related<br />

Issues: Most <strong>of</strong> underdeveloped<br />

countries do not have required<br />

technological infrastructure to<br />

establish national health<br />

information system hence cannot<br />

promote HIT in private and<br />

public hospitals. Reshaping<br />

infrastructure <strong>of</strong> existing health<br />

system is very crucial. Most<br />

developing countries do not have<br />

adequate required infrastructure<br />

such as computer hardware,<br />

s<strong>of</strong>tware, wired and wireless<br />

communication channels,<br />

Internet, and skilled pr<strong>of</strong>essional<br />

human resource. The availability<br />

and operation <strong>of</strong> these<br />

components <strong>of</strong> digital<br />

Infrastructure are necessary for<br />

establishment and promotion <strong>of</strong><br />

HIT in under developed<br />

countries. Strong infrastructure is<br />

required for the strong health<br />

information system to improve<br />

existing health system by<br />

planning and introducing new<br />

health care interventions which<br />

results in achieving better health<br />

goal. There are poor or inadequate<br />

resources allocation for<br />

implementation and use <strong>of</strong> the<br />

health technology in the<br />

developing countries.<br />

6. Hardware/S<strong>of</strong>tware: HIT<br />

requires specialized s<strong>of</strong>tware and<br />

hardware to improve public health<br />

by making evidence based<br />

decisions. Often these s<strong>of</strong>tware<br />

and hardware tools are costly and<br />

require sufficient training for<br />

proper operation.<br />

7. Poor Availability <strong>of</strong><br />

Internet: Poor internet availability<br />

is a vital infrastructure barrier.<br />

Health care specialists have poor<br />

access to real time information<br />

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Q. A. Qureshi et al. 41<br />

and the available information is<br />

not according to the local<br />

situation. This available<br />

information cannot be used for<br />

evidence based decisions. Without<br />

having a proper local area network<br />

and internet facility interorganizational<br />

and intraorganizational<br />

communication is<br />

not possible. This is a backbone<br />

for any information system.<br />

8. Lack <strong>of</strong> Pr<strong>of</strong>essionals &<br />

their Trainings: A computerized<br />

information system requires<br />

skilled personnel for its effective<br />

operation. Training is one <strong>of</strong> the<br />

aspects for use <strong>of</strong> any new<br />

technology. Deficiency <strong>of</strong> skilled<br />

workforce can be overcome by<br />

providing appropriate training in<br />

the required area. A proper<br />

training module in constructing<br />

architecture <strong>of</strong> a reliable database<br />

should be available. If it is not<br />

implemented then outcomes or<br />

results gained by such type <strong>of</strong><br />

databases gives unauthentic<br />

results which can neither be used<br />

for decision making process nor<br />

for evidence based practice.<br />

Training requires cost as well as<br />

time.<br />

9. Cost and Time<br />

Constraints: Major problem in<br />

organizing workshops and<br />

trainings for establishment and<br />

implementation <strong>of</strong> HIT in under<br />

developed countries is financial<br />

and time constraint.<br />

Transformation <strong>of</strong> any system is a<br />

difficult task and cannot complete<br />

in short time period. Barriers like<br />

lack <strong>of</strong> skilled workforce,<br />

infrastructure, and cost along with<br />

other effects like initial decrease<br />

<strong>of</strong> productivity due to adjustment<br />

with new technological<br />

environment and system itself<br />

impose strong limits to the<br />

introduction and adoption <strong>of</strong> new<br />

health technologies. It requires<br />

years and years for transformation<br />

process to complete.<br />

10. Educational Barriers:<br />

Pr<strong>of</strong>essional education in health<br />

informatics is badly ignored and<br />

missing in curriculum <strong>of</strong> medical<br />

institutes for undergraduates.<br />

Although module <strong>of</strong> education<br />

related to IT use in research is<br />

included in postgraduate<br />

curriculum but it is the need <strong>of</strong><br />

the hour to include this area in<br />

medical pr<strong>of</strong>essional education at<br />

graduate level. Transformation <strong>of</strong><br />

our existing paper based health<br />

system into computerized<br />

information system is not possible<br />

without providing the basic IT<br />

knowledge to health pr<strong>of</strong>essionals.<br />

11. Fear <strong>of</strong> losing Control over<br />

Data: The shift from traditional<br />

healthcare to e-healthcare<br />

involves the transformation <strong>of</strong><br />

records from paper-based to<br />

digital format. These records are<br />

referred to as Electronic<br />

Healthcare Record (EHR).<br />

Grimson (2001) defines and<br />

characterizes the next generation<br />

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EHR as the longitudinal cradle-tograve<br />

records readily accessible<br />

and available over the Internet.<br />

These records will be linked to<br />

clinical protocols and guidelines to<br />

drive the delivery <strong>of</strong> healthcare to<br />

the individual. The presence <strong>of</strong><br />

these records over the Internet<br />

facilitates record sharing between<br />

physicians. However, patients<br />

usually feel that they are losing<br />

control <strong>of</strong> their data hence<br />

resisting e-healthcare adoption.<br />

3.2 Prospects <strong>of</strong> e-Health in<br />

Pakistan<br />

The healthcare facilities in<br />

Pakistan has got better and<br />

increased in figure each year but<br />

this increase is not proportionate<br />

to the population growth<br />

.Therefore; the healthcare<br />

facilities are not that enough<br />

which can fulfill the needs and<br />

necessities <strong>of</strong> a large population.<br />

Persons particularly in rural areas<br />

face more difficulties <strong>of</strong> poor<br />

health than the people living in<br />

urban areas. Likewise, there has<br />

been a rise in expenses on<br />

healthcare planning and<br />

implementation but these<br />

expenditures on more and<br />

expanded healthcare setups are<br />

not enough for the population<br />

which is growing faster than the<br />

increase in the expenditure<br />

(Saleem, 2009). Moreover, there is<br />

also an increase in the number <strong>of</strong><br />

doctors, dentists and physicians<br />

every year .The increase in<br />

doctors and dentists number is<br />

more than the population growth<br />

which has decreased the number<br />

<strong>of</strong> patients/people for each doctor<br />

and dentist for treatment.<br />

In the present times <strong>of</strong><br />

management, a practical and<br />

structured information system is<br />

more or less a need and main<br />

concern <strong>of</strong> many organizations<br />

especially the healthcare<br />

institutions. In Pakistan, the old<br />

techniques and methods for data<br />

collection and analysis must be<br />

changed if the information in<br />

healthcare sector is to be used<br />

correctly for more effective<br />

healthcare-related activities and<br />

decisions. The Ministry <strong>of</strong><br />

Health, Government <strong>of</strong> Pakistan,<br />

in alliance with the provincial<br />

health departments and<br />

international agencies developed a<br />

National HMIS during 1990-93<br />

(Ali & Horikoshi, 2002). The<br />

facility based HMIS is one <strong>of</strong> the<br />

most influential tool for the<br />

planning and management <strong>of</strong><br />

healthcare services. In view <strong>of</strong> the<br />

existing huge health<br />

infrastructure, stretched all over<br />

the country in terms <strong>of</strong> health<br />

facilities, services, staff, drugs and<br />

supplies etc. there has been a<br />

requirement to start a wellorganized<br />

information system<br />

responding to the information<br />

needs <strong>of</strong> various decision making<br />

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Q. A. Qureshi et al. 43<br />

levels <strong>of</strong> the healthcare<br />

organizations(Durrani &<br />

Khoja, 2009).<br />

The relationship between the<br />

ICTs and better healthcare<br />

service delivery has been<br />

discussed significantly<br />

(Ferraro, 2008; Nowak, 2008).<br />

The present studies have<br />

focused on the introduction <strong>of</strong><br />

particular technologies, such as<br />

the cell phone or the Internet,<br />

but few have examined<br />

empirically the relationship in<br />

detail (Fraser et al.,2007;<br />

Kollmann et al., 2007). One<br />

probable method <strong>of</strong> tackling<br />

this dispute is appraisal and<br />

evaluation <strong>of</strong> user needs before<br />

adoption and use <strong>of</strong> eHealth<br />

systems. However, user studies<br />

which can be very helpful and<br />

productive for adoption <strong>of</strong> ITapplications<br />

in healthcare<br />

sector but unfortunately these<br />

studies are not always carried<br />

out at the right time in design<br />

and development cycle<br />

(Saleem, 2010).<br />

A lot <strong>of</strong> healthcare<br />

organizations implement<br />

telemedicine technology for the<br />

development <strong>of</strong> healthcare<br />

services and increase usefulness<br />

& effectiveness. The<br />

willingness <strong>of</strong> healthcare<br />

organizations and the<br />

availability <strong>of</strong> the suitable<br />

conditions are driving forces for<br />

the implementation and use <strong>of</strong><br />

telemedicine. Earlier studies<br />

showed that a telemedicine<br />

program can be disobeyed by<br />

organizational culture and work<br />

processes (Wootton, 2008)<br />

One main obstruction in e-<br />

Healthcare implementation, either<br />

in developed or developing states<br />

is privacy, secrecy and security<br />

concerns <strong>of</strong> e-Health systems.<br />

The American government, for<br />

example, for the year 2009<br />

reserved 19 billion dollars for ITapplications<br />

in healthcare sector.<br />

However, in spite <strong>of</strong> this massive<br />

investment, e-healthcare adoption<br />

in the USA is still hesitant. Its<br />

expected users for instance<br />

doctors and physicians are not<br />

convinced about the security<br />

issues and concerns <strong>of</strong><br />

information systems in healthcare<br />

organizations therefore they resist<br />

the implementation and use <strong>of</strong> the<br />

same. Furthermore, patients are<br />

also worried about the privacy <strong>of</strong><br />

their medical records. This has<br />

been influenced by a number <strong>of</strong><br />

existing cases involving violations<br />

in e-healthcare information<br />

systems. However, we disagree<br />

that adoption <strong>of</strong> eHealth systems<br />

is not a financial problem as such.<br />

It goes beyond, to include human<br />

faith and belief. Therefore, in<br />

spite <strong>of</strong> concentrating on securing<br />

funds for e-healthcare<br />

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implementation, developing states<br />

have to think about the human<br />

factor as well (Durrani & Khoja,<br />

2009).<br />

Though we suggest the use <strong>of</strong> Free<br />

and Open Source S<strong>of</strong>tware<br />

(FOSS) (from operating system<br />

to EHR s<strong>of</strong>tware) but due to<br />

shortage <strong>of</strong> money, these products<br />

are linked with many challenges.<br />

As these products are “free”, its<br />

users do not have any support and<br />

maintenance from development<br />

teams. The government <strong>of</strong><br />

developing countries needs to set<br />

aside sufficient finances for staff<br />

training in the healthcare sector.<br />

If e-health is to succeed in<br />

developing nations it needs to be<br />

take care <strong>of</strong>. We need to develop<br />

our own local abilities and<br />

infrastructure, based on local<br />

demand.<br />

The shared understanding and<br />

collaboration is a coordinated,<br />

synchronous activity that is the<br />

outcome <strong>of</strong> a continued effort to<br />

construct and uphold a shared<br />

conception <strong>of</strong> a problem.<br />

Cooperation is working jointly to<br />

achieve shared goals surrounded<br />

by joint and supportive activities<br />

individuals look for results which<br />

are advantageous to themselves<br />

and helpful to all other group<br />

members. Methodically and<br />

thoroughly structuring those basic<br />

elements into group learning<br />

circumstances helps ensure joint<br />

efforts and makes possible the<br />

closely controlled implementation<br />

<strong>of</strong> joint learning for lasting<br />

success (Kaplan, 2000). The<br />

advantages <strong>of</strong> collaborative<br />

learning are that persons bring<br />

different ideas in a collaborative<br />

environment and work on the<br />

way to the growth <strong>of</strong> a shared<br />

understanding and building usual<br />

knowledge (Tan , 2005). At<br />

present, the existing<br />

understanding seems to be that<br />

collaboration is a synonym for<br />

high-quality learning and good<br />

educational technology; more or<br />

less any web-based application is<br />

labeled as collaboration<br />

(Heinzelmann et al., 2003).<br />

Ever increasing charges for<br />

healthcare services and fast<br />

increase and development <strong>of</strong> the<br />

knowledge have led the doctors<br />

and physicians to work in a<br />

collaborative way and share<br />

knowledge and skills. It is usually<br />

understood that healthcare<br />

pr<strong>of</strong>essionals working in a<br />

collaborative style, can deliver<br />

healthcare services in a successful<br />

and well-organized manner.<br />

Collaborative learning process can<br />

exchange <strong>of</strong> ideas within little<br />

groups not only enhances interest<br />

between the participants but also<br />

generates and encourages critical<br />

thinking. Collaboration in<br />

healthcare organizations requires<br />

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Q. A. Qureshi et al. 45<br />

establishing a platform, and<br />

governmental responsibility to<br />

support sharing knowledge and<br />

experiences among healthcare<br />

workers (Durrani & Khoja, 2009).<br />

Collaboration and healthcare<br />

teams are very common in<br />

hospitals for durable and lasting<br />

healthcare facilities, but teams are<br />

<strong>of</strong>ten not available to providers in<br />

the community where the<br />

majority <strong>of</strong> practitioners work<br />

separately. Collaboration makes<br />

group members more adaptable<br />

and ultimately replaceable as the<br />

group as a learning community<br />

shares knowledge and<br />

experiences. Collaborative<br />

learning in healthcare<br />

organizations need to make and<br />

establish the environment that<br />

supports and encourages sharing<br />

<strong>of</strong> knowledge such as: government<br />

policy, IT infrastructure, top<br />

management support, and<br />

business process management to<br />

give doctors and physicians the<br />

capability <strong>of</strong> discussion and<br />

reflection (Scott et al., 2005).<br />

Pakistan’s ministry for healthcare<br />

has forecasted that Pakistan is<br />

grasping important benefits from<br />

the up-and-coming information<br />

economy. This is reflected in the<br />

current infrastructure investment<br />

and other hi-tech developments.<br />

In spite <strong>of</strong> this development, it<br />

seems that Pakistan is very slow<br />

in healthcare services provision.<br />

The slow adoption and use <strong>of</strong> ITapplications<br />

in the developing<br />

states like India and Pakistan is<br />

because <strong>of</strong> lack <strong>of</strong> management<br />

support (the perceived complexity<br />

and cost (Li et al., 2005, Houston<br />

et al., 2003, Lu et al., 2003);<br />

sensitive character and make-up<br />

<strong>of</strong> information and logistics<br />

contained in a healthcare facility,<br />

nature and type <strong>of</strong> risk involved,<br />

demands for high quality <strong>of</strong><br />

healthcare, high litigation cost and<br />

lack <strong>of</strong> infrastructure, the level <strong>of</strong><br />

absorption and assimilation with<br />

existing health systems(Li et al.,<br />

2005) and the requirement for<br />

other resources to support<br />

technology infrastructure<br />

(Davenport, 2005, Lu et al., 2003).<br />

While there is an increase in the<br />

usage <strong>of</strong> new technologies but<br />

there are limited studies on the<br />

perceptions and awareness <strong>of</strong><br />

doctors and physicians about the<br />

adoption and use <strong>of</strong> ITapplications<br />

in healthcare sector<br />

(Eastes, 2001, Li et al., 2005).<br />

Earlier studies that have used<br />

existing models to predict<br />

behavior determinants <strong>of</strong> adoption<br />

<strong>of</strong> technologies in healthcare have<br />

demonstrated their inadequacy.<br />

Further, the uptake <strong>of</strong> wireless<br />

and handheld tools and devices is<br />

either on a very small level on an<br />

individual level but are not at<br />

organizational levels in Pakistan.<br />

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There is limited research available<br />

on determinants and factors that<br />

are critical to understanding user<br />

perceptions <strong>of</strong> technologies<br />

specific to healthcare on a larger<br />

scale. Therefore, any knowledge<br />

<strong>of</strong> these factors <strong>of</strong> adoption <strong>of</strong><br />

new technology will help the<br />

healthcare administrators to<br />

develop suitable policies in order<br />

to handle the ever-increasing<br />

demands <strong>of</strong> healthcare services.<br />

This is more valid in the case <strong>of</strong><br />

Pakistan because <strong>of</strong> the demands<br />

placed on the healthcare services<br />

and rising interest in wireless<br />

technologies in the health domain.<br />

The culture <strong>of</strong> Pakistani<br />

environment has always<br />

encouraged the use <strong>of</strong> technology.<br />

This is high on the programs and<br />

plans at country and federal level<br />

government. The healthcare<br />

sector in Pakistan is operating in<br />

an environment <strong>of</strong> strong<br />

regulatory framework, cost<br />

reduction, high competition, and<br />

expectation <strong>of</strong> high quality <strong>of</strong><br />

services, high demand on the<br />

healthcare sector, limited<br />

resources, and the demand for<br />

providing high quality <strong>of</strong> care -<br />

anytime anywhere. Factors such<br />

as familiarity, infrastructure, cost,<br />

clinical process, quality <strong>of</strong> care,<br />

management support, policies and<br />

procedures, security, availability<br />

<strong>of</strong> appropriate wireless<br />

application, trust and knowledge<br />

<strong>of</strong> the technology will facilitate<br />

the adoption and hence the use <strong>of</strong><br />

wireless handheld devices in<br />

Pakistani healthcare environment.<br />

4. Discussions<br />

The process <strong>of</strong> developing and<br />

implementing IS in the context <strong>of</strong><br />

developing countries is a<br />

challenging endeavor. This<br />

challenge mainly emanates from<br />

existing adverse situation <strong>of</strong> the<br />

installed base that is characterized<br />

by uneven infrastructural<br />

development across regions,<br />

inadequate skilled manpower, lack<br />

<strong>of</strong> integration <strong>of</strong> exiting<br />

standards, work practices, and<br />

varying political commitment and<br />

organizational support at different<br />

levels (Raghupathi & Wu, 2011).<br />

Simply acquiring and<br />

implementing e-Health<br />

technology alone would be<br />

insufficient to accomplish clinical<br />

performance and, subsequently,<br />

drive adoption and diffusion. E-<br />

Health technology should be<br />

integrated effectively with the<br />

organizational change and<br />

improvement (Asangansi et al.,<br />

2008). The improvement in<br />

processes requires the<br />

optimization <strong>of</strong> clinical functions<br />

and processes which should be<br />

supported by the technology and<br />

not driven by it. By doing this it is<br />

likely to generate significant<br />

patient outcomes and financial<br />

©2014 <strong>Mediterranean</strong> Center <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong>


Q. A. Qureshi et al. 47<br />

improvements with health<br />

organizations. This is estimated in<br />

terms <strong>of</strong> attracting more patients,<br />

saving effort and time (Bhutto et<br />

al., 2010).Furthermore, in the<br />

context <strong>of</strong> developing states like<br />

Pakistan, the cost constitutes an<br />

important factor which will affect<br />

the integration and, subsequently,<br />

the success <strong>of</strong> eHealth systems in<br />

a particular setting. Although cost<br />

aspects are not directly explored,<br />

however, efforts to save time,<br />

reduction in inaccuracies and high<br />

quality information are real<br />

components <strong>of</strong> the cost (Somu &<br />

Bhaskar,2011). While existing<br />

research suggests that wireless<br />

technology has the power to<br />

decrease scheduling time and<br />

medical errors thereby enhancing<br />

the quality in patient care, there is<br />

bleak evidence on the<br />

comparisons <strong>of</strong> costs before and<br />

after the implementation <strong>of</strong><br />

wireless technologies. It entails<br />

that there is a big space for further<br />

research to assess the hypothesis<br />

that costs have the potential to<br />

affect clinical usefulness and<br />

threaten widespread adoption<br />

(Juma et al., 2012). Use <strong>of</strong> e-health<br />

systems in developing countries<br />

holds many threats, along with<br />

the expected advantages. The<br />

main risk <strong>of</strong> using ICTs is the<br />

unintentional broadening <strong>of</strong> the<br />

gap in health status and<br />

knowledge between various<br />

segments <strong>of</strong> the population, thus<br />

escalating rather than addressing<br />

healthcare inequalities. One<br />

method to stay away from this<br />

divide is for government<br />

authorities and hospitals in<br />

developing countries to evaluate<br />

and make them ready for change<br />

before adoption and use <strong>of</strong> ITapplications.<br />

This process <strong>of</strong><br />

preparation for eHealth related<br />

change is also termed as eHealth<br />

readiness (Durrani et al., 2012).<br />

eHealth readiness is determined<br />

by assessing the comparative<br />

status <strong>of</strong> governments, healthcare<br />

organizations, or expected users in<br />

those areas most critical for<br />

acceptance and success <strong>of</strong><br />

programs using ICT (Rezai-Rad<br />

et al., 2012).<br />

5. Conclusions<br />

Literature reveals that e-Health<br />

systems are the future <strong>of</strong> every<br />

healthcare service being provided<br />

in the advanced, developing and<br />

poor states. developing states are<br />

interested and busy in the<br />

improvement <strong>of</strong> healthcare-sector<br />

and that is why these nations keep<br />

on to decentralize their political<br />

and healthcare systems, they need<br />

to make available all the required<br />

payments and grants for the weak<br />

and insufficient resources and<br />

powerless abilities and<br />

qualifications <strong>of</strong> the urban areas.<br />

Although the speed and tempo <strong>of</strong><br />

introducing digital systems for<br />

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<strong>Mediterranean</strong> <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> <strong>Sciences</strong> V1, I1 October 2014: 31-52 48<br />

healthcare is altogether different<br />

from advanced to developing<br />

countries like Pakistan, all the<br />

states are making all out efforts to<br />

adopt these systems. This attitude<br />

is based on the fact that the ICTs<br />

have <strong>of</strong>fered such options that<br />

were almost unimaginable so far.<br />

E-Health systems are helping the<br />

developing and poor states in<br />

resolving their long standing<br />

problems in healthcare facilities<br />

and services. Furthermore, the<br />

research tells that once a country<br />

is capable to introduced e-Health<br />

system, its success depends on the<br />

users’ ‘e-Readiness’ for willingly<br />

using the new systems. A huge<br />

body <strong>of</strong> research is underway to<br />

explore the dynamics <strong>of</strong> users’<br />

readiness. There are several<br />

variables which determine the<br />

users’ attitude however the most<br />

powerful and unavoidable<br />

determinant is the ‘digitalliteracy’<br />

<strong>of</strong> the prospected users.<br />

Research shows that as the<br />

computer literacy <strong>of</strong> the e-Health<br />

users (like doctors) increases, the<br />

possibility <strong>of</strong> successful e-Health<br />

operations also increases.<br />

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