Renal replacement therapy_Susla (3)
Renal replacement therapy_Susla (3)
Renal replacement therapy_Susla (3)
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Pharmacokinetics<br />
of<br />
Continuous<br />
<strong>Renal</strong> Replacement Therapy<br />
Basic Principles<br />
• Extracorporeal clearance (Cl EC ) is usually considered<br />
clinically significant only if its contribution to total<br />
body clearance exceeds 25 - 30%<br />
Fr EC = Cl EC / Cl EC + Cl R + Cl NR<br />
• Not relevant for drugs with high non-renal clearance<br />
• Only drug not bound to plasma proteins can be<br />
removed by extracorporeal procedures<br />
Determinants of<br />
Drug Removal by CRRT<br />
• Drug<br />
• Membrane<br />
• <strong>Renal</strong> <strong>replacement</strong><br />
technique<br />
Same as hemodialysis<br />
but increased MW range<br />
Permeability, Size<br />
Sieving Coefficient<br />
Convection + diffusion Cl<br />
Flow rates<br />
Duration<br />
Blood, Dialysate, UF<br />
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