Lab Brochure - Laboratory of Integrated Bio Medical Micro ...
Lab Brochure - Laboratory of Integrated Bio Medical Micro ...
Lab Brochure - Laboratory of Integrated Bio Medical Micro ...
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2002-2003<br />
Self-Assembly<br />
Project Highlights<br />
BASIC: BIO-INSPIRED ASSEMBLY OF<br />
SEMICONDUCTOR ICs<br />
ssDNA<br />
2 Face-to-<br />
Face Au<br />
layers<br />
Oxide<br />
<strong>Lab</strong>oratory <strong>of</strong> <strong>Integrated</strong><br />
<strong>Bio</strong>medical <strong>Micro</strong>/Nano-<br />
Technology and Applications<br />
(LIBNA)<br />
Project Highlights<br />
<strong>Micro</strong>-fluidic Cell Culture Arrays<br />
700 Pin<br />
µm<br />
Glass cover<br />
Devices<br />
Complementary molecules<br />
and/or electric field<br />
Assembly and selective placement<br />
<strong>of</strong> silicon on plastics and glass<br />
Dielectrophoretic Sorting and Separation<br />
<strong>of</strong> Cells<br />
Cell sorting: live cells (green,<br />
positive DEP), dead cells (red,<br />
negative DEP)<br />
AFM Imaging <strong>of</strong> Virus and Bacteria<br />
Listeria<br />
Beads<br />
and<br />
bacteria<br />
Flow<br />
Detection<br />
Chamber<br />
Silicon<br />
Islands<br />
DEP based micr<strong>of</strong>luidic<br />
filters and valves<br />
Human Corona Virus<br />
Electrodes<br />
Flow<br />
Output<br />
channel<br />
MEMS/<strong>Bio</strong>MEMS<br />
<strong>Bio</strong>-Mimetics<br />
PI: Rashid Bashir<br />
Nanotechnology<br />
<strong>Micro</strong>/Nano<br />
<strong>Bio</strong>/Chem Sensors<br />
<strong>Integrated</strong><br />
<strong>Bio</strong>-Chips<br />
Implantable<br />
<strong>Micro</strong>-Devices<br />
<strong>Bio</strong>technology<br />
Self-Assembly<br />
Self-Assembling<br />
Electronics<br />
In/Out ports<br />
Epoxy adhesive<br />
Rapid electrical detection and characterization<br />
<strong>of</strong> cells with on chip dielectrophoretic cell sorting<br />
Resonant Cantilevers for <strong>Bio</strong>logical<br />
Sensing Applications<br />
Ab, BSA and<br />
~ 80 Bacteria<br />
(78.2kHz)<br />
Ab and<br />
BSA<br />
(78.7kH<br />
z)<br />
Unloaded<br />
(80.7kHz)<br />
Detection <strong>of</strong> bacterial agents and binding<br />
<strong>Micro</strong>/Nano-mechanical Cantilevers<br />
for Virus Detection<br />
Cavities/<br />
Wells<br />
Cantilever<br />
over a well<br />
Polymer<br />
Bacteria and virus on micr<strong>of</strong>abricated<br />
surfaces <strong>of</strong> biochips<br />
Ultra-sensitive pH <strong>Micro</strong>-Sensors<br />
∆pH = 1-10e-5<br />
50 µm<br />
Deflection at the tip (µm)<br />
25<br />
20<br />
15<br />
10<br />
5<br />
0<br />
Experiment<br />
Model<br />
2.5 3.5 4.5 5.5 6.5 7.5 8.5<br />
pH <strong>of</strong> Fluid Around the Cantilever<br />
Environmentally sensitive micro-patterned<br />
polymer structures on cantilever sensors<br />
slope = 18.3µm/pH<br />
(=1nm/5e-5pH)<br />
Cantilevers<br />
touched the<br />
bottom<br />
Applications<br />
<strong>Bio</strong>sensors, Electronics,<br />
Food Safety, Homeland<br />
Security, Medicine<br />
For more information visit:<br />
www.ecn.purdue.edu/<strong>Bio</strong>MEMS/<br />
Au<br />
Silicon<br />
Technology development for the rapid<br />
detection <strong>of</strong> virus particles from air<br />
<strong>Integrated</strong> <strong>Bio</strong>-Molecular Sensors<br />
<strong>Integrated</strong><br />
Nano-wire<br />
Au<br />
Capture<br />
Target<br />
Molecules<br />
Molecules<br />
oxide<br />
N-/P-<br />
• Plate Size ~ 20nm X 1µm X 3 µm<br />
• Wire Size ~ 20nm X 20nm X 3 µm<br />
Metal N+<br />
N+<br />
P type Silicon<br />
<strong>Integrated</strong><br />
Bottom Gate<br />
<strong>Bio</strong>-sensors with electronic output, capability <strong>of</strong><br />
dense arrays integrated with ULSI silicon, direct<br />
<strong>Lab</strong>el Free detection <strong>of</strong> DNA and Proteins
Team:<br />
• Pr<strong>of</strong>. Rashid Bashir<br />
• Three Specialist Senior Researchers<br />
• Nine Graduate Students<br />
• On-going Summer Students<br />
Collaborators:<br />
Ag& <strong>Bio</strong> Engr., <strong>Bio</strong>medical Engr.,<br />
<strong>Bio</strong>logy, Chemical Engr., Electrical &<br />
Computer Engr., Food Science,<br />
Medicinal Chemistry<br />
Funding:<br />
US Department <strong>of</strong> Agriculture, NASA,<br />
NSF Career Award, National Institute <strong>of</strong><br />
Health, DARPA<br />
Outreach:<br />
Undergraduate and High School Student<br />
Projects, Technology Commercialization<br />
Center Affiliations at Purdue:<br />
• Birck Nanotechnology Center<br />
• Bindley <strong>Bio</strong>sciences Center<br />
•NASA Institute <strong>of</strong> Nanoelectronics and<br />
Computing<br />
• USDA-Food Safety Engineering Center<br />
<strong>Lab</strong>oratory <strong>of</strong> <strong>Integrated</strong><br />
<strong>Bio</strong>medical <strong>Micro</strong>/Nano-<br />
Technology and Applications<br />
(LIBNA)<br />
465 Northwestern Avenue,<br />
School <strong>of</strong> Electrical and<br />
Computer Engineering,<br />
Department <strong>of</strong> <strong>Bio</strong>medical<br />
Engineering,<br />
Purdue University,<br />
West Lafayette, IN. 47907-2035<br />
765-496-6229<br />
765-494-6441 (fax)<br />
bashir@ecn.purdue.edu<br />
For more information visit:<br />
www.ecn.purdue.edu/<strong>Bio</strong>MEMS/<br />
Positions:<br />
Post-doctoral positions<br />
available, please visit web-site
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