Microsatellite markers

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Microsatellite markers (Cont’) 6. Microsatellites have a high probability of back mutation 7. Polymorphism is generated by loss or gain of repeats (MIN; microsatellite instability). Tool for cancer genetics. 8. Human microsatellites average at least 10 alleles with heterozygosity per locus over 80% A crucial tool in forensic analysis and paternity test. 9. As markers for pedigree analysis and family disease tracing.
Genetic mapping & resolution RFLP (coverage 1/ 10 cM) map single gene disorder. Microsatellite markers (1/10 kb) map more complex diseases SNP (1/1~1.5 kb) the third generation map & map functional variation in gene
Page 1 and 2: Microsatellite markers
Page 3 and 4: 25% 45% 8% 21% 13% 3%
Page 6 and 7: LINE = A type of large repetitive D
Page 8 and 9: Tandem repeats (SSR; Simple sequenc
Page 11 and 12: Microsatellite is distributed along
Page 13: Microsatellite markers 1. Consist o
Page 23 and 24: Protocol to detect multi-allelic ma
Page 38 and 39: Genetic Instability of Cancer Genet
Page 40 and 41: Parents Microsatellite marker Prime
Page 42 and 43: Parents delete destroy Primers Micr
Page 44 and 45: Normal Cancer Mixed
Page 46 and 47: Method for genotyping by microsatel
Page 48 and 49: Microsatellite marker needs the lon
Page 50: Fluorescence-based microsatellite g
Page 56: microsatellite marker detection By
Page 61: Melting curve & DNA length
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SYBR Green I stain is a highly sens
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254nm
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Real-Time PCR with SYBR Green
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Real-Time PCR with SYBR Green
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mother son daughter
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Microsatellite markers

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