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Surgical Site Infection and the Operating Room Checklist - Safer ...

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SHN! Recommendation 1<br />

• Based on <strong>the</strong> evidence, <strong>the</strong> <strong>Safer</strong> Healthcare Now! faculty<br />

recommend that prophylactic antibiotics be completely<br />

absorbed within 60 minutes of first incision, <strong>and</strong> should<br />

be repeated for surgeries lasting longer than <strong>the</strong> half-life life<br />

of <strong>the</strong> antibiotic (4 hours for cephalosporins).<br />

• Antibiotics administered for cardiac, thoracic,<br />

orthopaedic <strong>and</strong> vascular patients should be discontinued<br />

within 24 hours of <strong>the</strong> end of surgery, whereas noncomplex<br />

<strong>and</strong> uncomplicated surgeries require no fur<strong>the</strong>r<br />

administration of antibiotics following surgery.<br />

1. <strong>Safer</strong> Healthcare Now! Getting Started Kit: <strong>Surgical</strong> <strong>Site</strong> <strong>Infection</strong> Prevention, March 2010

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