2011 AAAS and AP Airway Disease Summit Oct. 15th - 台灣兒科醫學會

2011 AAAS and AP Airway Disease Summit
Oct. 15 th - Oct. 16 th , 2011
Time Topic Speaker Moderator
AP Airway Disease Summit Day 1 October 15, Saturday
08:50-09:00 Opening Remark Chang Gung University
09:00-09:40 Severe Asthma: What is it and phenotyping Kian-Fan Chung (UK)
09:40-10:20 Cytokines and Chemokines in Severe Asthma Qutayba Hamid (CA)
Sow-Hsong Kuo (TW)
Bor-Luen Chiang (TW)
10:20-10:35 Coffee Break
10:35-11:15
Fibrocytes in Asthma and COPD: Link to airflow
obstruction
Chun-Hwa Wang (TW)
Chong-Jen Yu (TW)
11:15-11:55 Environment and Asthma Shau-Ku Huang (TW)
12:05-12:55 Poster Discussion: Difficult to treat Asthma
Richard Loh (MY)
Jiang-Tao Lin (CN)
13:05-13:45 COPD phenotypes in Asia Sang Do Lee (KR)
13:45-14:25 New treatments for COPD Masakazu Ichinose (JP)
Ming-Shyan Huang (TW)
Jeng-Yuan Hsu (TW)
14:25-14:40 Coffee Break
14:40-15:20 Role of bacterial infections in COPD David SC Hui (HK)
15:20-16:00 Oxidative stress and corticosteroid insensitivity Ian M Adcock (UK)
Yu-Chin Lee (TW)
16:10-17:00 Poster Discussion: Co-Morbidities in COPD
Kang-Yun Lee (TW)
Akio Niimi (JP)
18:00~ Welcome Dinner
AP Airway Disease Summit Day 2 October 16, Sunday
09:00-09:40 Genomics of COPD Marc Lenburg (US)
09:40-10:20 Biomarkers of COPD Don Sin (CA)
Han-Pin Kuo (TW)
10:20-10:40 Coffee Break
10:40-11:20 Pulmonary rehabilitation for chronic lung disease Shu-Min Lin (TW) Horng-Chyuan Lin (TW)
11:20 Closing Remark Co-Chair, Kian-Fan Chung (UK)

Professor Kian Fan Chung MD DSc FRCP
Professor Chung is Professor of Respiratory Medicine and Head of Experimental
Studies Unit at National Heart & Lung Institute, Imperial College London, and is an
Honorary Consultant Physician at the Royal Brompton Hospital, London. Professor
Chung trained in internal and respiratory medicine in Oxford and London, and did
postdoctoral training as MRC Visiting Scientist at the University of California in San
Francisco. He was awarded MD (1983) and DSc (2001) degrees from the University of
London, London, UK.
Professor Chung is a Senior Investigator of the UK National Institute for Health
Research. He is co‐leader of the IMI‐funded EU/EFPIA UBIOPRED project on Systems
Biology of severe asthma. He has received or in current receipt of research grants
from the Medical Research Council, The Wellcome Trust, US Health Effects Institute,
EU Innovative Medicines Initiative, National Environmental Research Council (UK),
Asthma UK and the National Institutes of Health.
Professor Chung currently serves on the editorial boards of several respiratory and
pharmacological journals. He has authored and co‐authored more than 750 scientific
articles, reviews and book chapters, and edited/co‐edited 10 books

Qutayba Hamid, M.D., Ph.D., FRCP, FRCPath
Dr Hamid is Professor of Medicine at McGill University. He is the James
McGill Professor of Medicine, MUHC Strauss Chair in Respiratory Medicine, Director
of the Meakins Christie Laboratories, Director of the Montreal Chest Institute and
Associate Director of the McGill University Health Centre Research Institute.
Dr. Hamid has published over 400 scientific articles in prestigious international
journals and has contributed more than 150 chapters and review articles. He is the
editor of 2 textbooks for Respiratory Cell and Molecular Biology and Respiratory
Physiology. He has been a visiting professor worldwide at Universities in Japan, USA
and Europe.
He is currently the Co-Editor of Clinical and Experimental Allergy and has
served in many editorial boards. Dr Hamid is a member of many scientific and
professional organizations including Royal College of Physicians, London, UK, Royal
College of Physicians, Canada. He is a fellow of the American Academy of Allergy,
Asthma and Immunology and the Royal College of Pathologists.
Dr Hamid holds many competitive grants including MRC, CIHR and NIH grants.
He is member of many grant peered review committees and has served on the CIHR.
He is also a member of advisory boards of many drug companies.
The main area of research interest of Dr. Hamid includes pathogenesis of
asthma, role of cytokines and chemokines in allergic diseases, role of distal airways
in asthma and COPD, new therapy in asthma and allergy.
September 2010

Dr. Chun‐Hwa Wang 王 圳 華 醫 師
學 經 歷 :
私 立 中 國 醫 藥 學 院 醫 學 系 畢 業
長 庚 醫 院 胸 腔 內 科 助 理 教 授
長 庚 醫 院 胸 腔 內 科 臨 床 研 究 員
長 庚 紀 念 醫 院 林 口 院 區 胸 腔 內 科 主 治 醫 師
長 庚 紀 念 醫 院 胸 腔 內 科 呼 吸 道 疾 病 科 主 任
長 庚 大 學 副 教 授
王 圳 華 醫 師 為 全 台 知 名 胸 腔 內 科 呼 吸 道 疾 病 科 醫 師 , 在 診 斷 與 治 療 氣 喘 方 面 更
有 卓 越 的 成 就 。 有 鑑 於 現 今 氣 喘 病 人 對 於 氣 喘 診 療 指 引 的 連 從 性 及 自 我 照 護 能
力 明 顯 不 足 , 曾 與 另 外 三 名 教 授 共 同 發 表 「 胸 腔 內 科 呼 吸 道 疾 病 科 」, 以 氣 喘
病 患 的 自 我 評 估 及 自 我 處 理 為 氣 喘 長 期 治 療 的 主 要 目 標 , 提 出 一 套 氣 喘 網 路 會
診 系 統 - 氣 喘 格 網 - 以 增 加 病 患 對 於 自 身 氣 喘 病 嚴 重 程 度 的 暸 解 及 更 完 整 的 氣
喘 病 處 理 建 議 , 同 時 評 估 此 氣 喘 網 路 會 診 系 統 所 做 的 氣 喘 評 估 及 處 置 建 議 對 於
氣 喘 病 人 是 否 實 用 。

Dr. Shau‐Ku Huang 黃 嘯 谷 博 士
黃 博 士 於 1981 年 取 得 台 北 醫 學 大 學 學 士 學 位 ,1989
年 獲 得 美 國 佛 蒙 特 大 學 免 疫 學 博 士 學 位 , 並 於 約 翰 霍 普
金 斯 大 學 醫 學 院 過 敏 與 臨 床 免 疫 部 門 進 行 博 士 後 研 究 。
在 博 士 後 研 究 期 間 榮 獲 了 聲 望 極 高 的 獎 項 —the
Irvington Medical Institute Postdoctoral
Fellowship Award, 爾 後 擔 任 約 翰 霍 普 金 斯 大 學 助 理
教 授 時 獲 得 了 Merrell-Dow and American Academy
of Allergy,Asthma and Immunology Scholar in
Allergy Award; 返 國 前 任 職 約 翰 霍 普 金 斯 大 學 醫 學 院
教 授 。
黃 博 士 在 約 翰 霍 普 金 斯 大 學 期 間 , 主 要 研 究 過 敏 發 炎 反 應 的 機 制 , 為 國 際 認 可
之 發 炎 反 應 疾 病 免 疫 調 節 研 究 的 領 導 者 。 他 致 力 於 過 敏 發 炎 反 應 , 涵 括 基 因 、
分 子 生 物 、 基 因 體 與 動 物 模 式 及 轉 譯 方 面 的 研 究 等 , 並 發 表 許 多 具 有 權 威 性 之
論 述 文 章 。 他 在 科 學 上 的 貢 獻 包 括 發 現 細 胞 激 素 與 其 作 用 機 制 , 以 及 探 討 它 們
在 生 物 體 內 於 疾 病 上 所 扮 演 的 角 色 。 此 外 , 黃 博 士 研 究 團 隊 也 率 先 研 發 調 節 過
敏 性 疾 病 的 基 因 疫 苗 , 並 持 續 在 這 領 域 發 展 所 長 。
黃 博 士 在 美 期 間 與 研 究 團 隊 發 現 樹 突 細 胞 中 的 先 天 免 疫 接 受 器 C-type lectin
receptors, 對 於 過 敏 原 與 先 天 免 疫 上 扮 演 了 辨 識 上 的 決 定 性 角 色 。 近 期 發 表 於
Nature Medicine(2010 Oct;16:1128-33) 的 研 究 中 發 現 一 種 特 別 的 接 收 器
—SIGNR1 表 現 於 一 種 稱 為 LPDC(lamina propria dendritic cell) 的 免 疫
細 胞 中 。 這 種 細 胞 存 在 於 腸 胃 道 中 並 對 身 體 的 免 疫 系 統 扮 演 了 第 一 道 防 線 。
SIGNR1 具 有 特 別 的 甘 露 醣 (mannose) 醣 化 蛋 白 質 , 是 C-type lectin
receptor 的 成 員 。 而 由 特 化 醣 基 蛋 白 質 啟 動 SIGNR1 後 , 可 使 LPDC 產 生 調
控 蛋 白 質 並 增 加 細 胞 促 進 容 許 的 程 度 , 而 讓 原 本 的 過 敏 反 應 顯 著 地 降 低 , 並 增
加 對 過 敏 原 的 容 許 度 。
黃 博 士 目 前 針 對 先 天 免 疫 反 應 在 控 制 過 敏 發 炎 的 主 軸 下 做 研 究 。 此 外 , 與 高 雄
醫 學 大 學 共 同 研 究 基 因 與 環 境 的 相 互 作 用 及 過 敏 疾 病 的 成 因 , 包 括 一 些 常 見 的
疾 病 , 例 如 : 氣 喘 與 異 位 性 皮 膚 炎 。 此 合 作 計 畫 的 總 體 目 標 在 於 確 定 環 境 曝 露
與 表 現 疾 病 之 間 的 機 制 , 並 提 供 發 展 有 效 治 療 與 預 防 策 略 的 基 礎 , 增 進 全 民 健
康 福 祉 。 此 計 畫 將 從 臨 床 研 究 、 基 因 體 學 、 系 統 生 物 學 、 免 疫 途 徑 、 體 外 機 制
研 究 或 是 動 物 模 式 角 度 進 行 關 鍵 性 問 題 研 究 。
黃 嘯 谷 博 士 目 前 擔 任 環 境 衛 生 與 職 業 醫 學 研 究 組 特 聘 研 究 員 。

Professor Sang‐Do Lee
Korea
Sang‐Do Lee is the professor of medicine in the Department of Pulmonary & Critical
Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul,
Korea.
Professor Lee earned his medical degree from the Seoul National University College of
Medicine in 1982, and subsequently underwent general internal medicine and
pulmonary medicine training at the Seoul National University Hospital. From 1996 to
1997, he was a visiting professor at the University of Colorado Health Sciences Center,
Denver, CO, USA. Professor Lee earned his MS degree from the Seoul National
University in 1989, and his PhD in 1991. He has taught at the Chungbuk National
University, Cheongju, and has taught at the University of Ulsan since 1995. He is a
director of the clinical research center for chronic obstructive airway diseases, funded
by the government, since 2004. He has organized and is running an annual international
symposium on airway disease (“Airway Vista”) and ANOLD (Asian Network for
Obstructive Airway Diseases) since 2008.
Professor Lee is a widely published investigator, with over 280 peer‐reviewed articles to
his name. He has been an editor‐in‐chief of ‘Tuberculosis and Respiratory Diseases’.

MASAKAZU ICHINOSE, MD
Professor of Medicine
DATE OF BIRTH: 19th September 1954
PLACE OF BIRTH:
Fukushima prefecture
NATIONARITY:
Japanese
STATUS:
Married, with 2 children
ADDRESS: Third Department of Internal Medicine
Wakayama Medical University School of Medicine
811-1 Kimiidera, Wakayama 641-0012, Japan
TEL: 81-73-441-0618 (including country code)
FAX: 81-73-446-2877
E-mail: masakazu@wakayama-med.ac.jp
EDUCATION:
BACHELOR OF MEDICINE
1980 Tohoku University School of Medicine
RESIDENCY & FELLOWSHIP
1980-1982 Isawa Hospital
1982-1988 Research fellow: First Department of Internal Medicine,
Tohoku University School of Medicine
ACADEMIC AFFLIATIONS
1988-1990 Visiting Scientist: Department of Thoracic Medicine,
National Heart & Lung Institute, UK (Professor Peter J Barnes)
1990-2001 Assistant Professor: First Department of Internal Medicine
Tohoku University School of Medicine
2002 Associate Professor: Division of Respiratory & Infectious Diseases,
Tohoku University Graduate School of Medicine
2003 Professor: Third Department of Internal Medicine
Wakayama Medical University School of Medicine

MEDICAL DOCTOR
1990 Tohoku University
AWARDS
1994 Young Investigator Award (Japanese Respiratory Society)
1996 Japanese Society of Allergology Award
1999 Kumagai Award (Japanese Respiratory Society)
2003 Gold Prize of Tohoku University School of Medicine
SCIENTIFIC SOCIETIES:
Japanese Society of Internal Medicine
Japanese Respiratory Society
Japanese Society of Allergology
American Thoracic Society (ATS)
European Respiratory Society (ERS)
International Society for Aerosols in Medicine (ISAM)
EDITORIAL BOARD:
1995-1997 Pulmonary Pharmacology (Academic Press)
2000- Respiratory Research (Current Science Ltd)
2005- American Journal of Respiratory & Critical Care Medicine
2006-2010 Thorax (International Advisory Board)
EDITOR IN CHIEF (Pacific Rim)
1997-present Pulmonary Pharmacology & Therapeutics

PEER-REVIEWED PUBLICATIONS
1. M. Ishii, N. Matsumoto, T. Fuyuki, W. Hida, M. Ichinose, H. Inoue, T. Takishima. Effects
of hemodynamic edema formation on peripheral vs central airway mechanics. J Appl
Physiol 1985; 59:1578-1584
2. N. Matsumoto, H. Inoue, M. Ichinose, M. Ishii, C. Inoue, H. Sasaki, T. Takishima.
Effective sites by sympathetic beta-adrenergic and vagal nonadrenergic inhibitory
stimulation in constricted airways. Am Rev Respir Dis 1985; 132: 1113-1117
3. Y.N. Liu, H. Sasaki, M. Ishii, K. Sekizawa, W. Hida, M. Ichinose, T. Takishima. Effect of
circadian rhythm on bronchomotor tone after deep inspiration in normal and in asthmatic
subjects. Am Rev Respir Dis 1985; 132: 278-282
4. W. Hida, M. Sakurai, M. Ichinose, C. Shindoh, T. Chonan, Y. Kikuchi, H. Inoue, T.
Takishima. Effect of clenbuterol on peripheral airway obstruction in bronchial asthma.
Cur Med Res Opin 1985; 9: 616-625
5. H. Inoue, S. Horio, M. Ichinose, S. Ida, W. Hida, T. Takishima, K. Ohwada, M. Honma.
Changes in bronchial reactivity to acetylcholine with type C influenza virus infection in
dogs. Am Rev Respir Dis 1986; 133: 367-371
6. M. Ichinose, H. Inoue, M. Miura, N. Yafuso, H. Nogami, T. Takishima. Possible sensory
receptor of nonadrenergic inhibitory nervous system. J Appl Physiol 1987; 63: 923-929
7. M. Ichinose, H. Inoue, M. Miura, T. Takishima. Nonadrenergic bronchodilation in normal
subjects. Am Rev Respir Dis 1988; 138: 31-34
8. M. Miura, H. Inoue, M. Ichinose, S. Shimura, T. Takishima. Distribution of α-adrenergic
bronchoconstriction in feline airways. Pulm Pharm 1988; 1: 63-68
9. M.G. Belvisi, M. Ichinose, P.J. Barnes. Modulation of non-adrenergic, non-cholinergic
neural bronchoconstriction in guinea -pig airways via GABA B -receptors. Br J Pharmacol
1989; 97: 1225-1231
10. M. Ichinose, C.D. Stretton, J.C. Schwartz, P.J. Barnes. Histamine H 3 -receptors inhibit
cholinergic neurotransmission in guinea-pig airways. Br J Pharmacol 1989; 97: 13-15
11. M. Ichinose, P.J. Barnes. Inhibitory histamine H 3 -receptors on cholinergic nerves in
human airways. Eur J Pharmacol 1989; 163: 383-386
12. M. Ichinose, P.J. Barnes. Histamine H 3 -receptors modulate nonadrenergic noncholinergic
neural bronchoconstriction in guinea-pig in vivo. Eur J Pharmacol 1989; 174: 49-55
13. P.J. Barnes, M. Ichinose. H 3 -receptors in airways. Trends Pharmacol Sci 1989; 10: 264
14. Y. Nishimura, W. Hida, O. Taguchi, M. Sakurai, M. Ichinose, H. Inoue, T. Takishima.
Respiratory muscle strength and gas exchange in neuromuscular diseases: comparison
with chronic pulmonary emphysema and idiopathic pulmonary fibrosis. Tohoku J Exp
Med 1989; 159: 57-68
15. H. Inoue, M. Ichinose, M. Miura, U. Katsumata, T. Takishima. Sensory receptors and
reflex pathways of nonadrenergic inhibitory nervous system in feline airways. Am Rev
Respir Dis 1989; 139: 1175-1178
16. M. Miura, H. Inoue, M. Ichinose, S. Simura, K. Kimura, Y. Shindoh, Y. Tanno, T.
Takishima. Increase in luminal mast cell and epithelial damage may account for
increased airway responsiveness after viral infection in dogs. Am Rev Respir Dis 1989;
140: 1738-1744

17. M. Ishii, W. Hida, S. Suzuki, M. Ichinose, H. Sasaki, T. Takishima. Comparison of
intermittent and continuous inhalation provocation tests. Annals Allergy 1989; 62:
223-228
18. M. Ichinose, P.J. Barnes. Histamine H 3 -receptors modulate antigen-induced
bronchoconstriction in guinea pigs. J Allergy Clin Immunol 1990; 86: 491-495
19. M. Ichinose, P.J. Barnes. A potassium channel activator modulates both excitatory
noncholinergic and cholinergic neurotransmission in guinea pig airways. J Pharmacol
Exp Ther 1990; 252: 1207-1212
20. M. Ichinose, P.J. Barnes. Bradykinin-induced airway microvascular leakage and
bronchoconstriction mediated via a bradykinin B 2 receptor. Am Rev Respir Dis 1990; 142:
1104-1107
21. M. Ichinose, M.G. Belvisi, P.J. Barnes. Bradykinin-induced bronchoconstriction in guinea
pig in vivo: role of neural mechanisms. J Pharmacol Exp Ther 1990; 253: 594-599
22. M. Ichinose, P.J. Barnes. The effect of peptidase inhibitors on bradykinin-induced
bronchoconstriction in guinea-pigs in vivo. Br J Pharmacol 1990; 101: 77-80
23. M. Ichinose, M.G. Belvisi, P.J. Barnes. Histamine H 3 -receptors inhibit neurogenic
microvascular leakage in airways. J Appl Physiol 1990; 68: 21-25
24. U. Katsumata, M. Miura, M. Ichinose, K. Kimura, T. Takahashi, H. Inoue, T. Takishima.
Oxygen radicals produce airway constriction and hyperresponsiveness in anesthetized
cats. Am Rev Respir Dis 1990; 141: 1158-1161
25. M. Miura, H. Inoue, M. Ichinose, K. Kimura, U. Katsumata, T. Takishima. Effect of
nonadrenergic noncholinergic inhibitory nerve stimulation on the allergic reaction in cat
airways. Am Rev Respir Dis 1990; 141: 29-32
26. H. Inoue, M. Ichinose, M. Miura, H. Iijima, K. Kimura, U. Katsumata, I. Hataoka, S.
Okada, M. Asano, T. Takishima. Nonadrenergic inhibitory nervous systems in the
airways. Am Rev Respir Dis 1991; 143: S15-S17
27. K. Kimura, H. Inoue, M. Ichinose, M. Miura, U. Katsumata, T. Takahashi, T. Takishima.
Bradykinin causes airway hyper-responsiveness and enhances maximal airway
narrowing: role of microvascular leakage and airway edema. Am Rev Respir Dis 1992;
146: 1301-1305
28. M. Ichinose, N. Nakajima, T. Takahashi, H. Yamauchi, H. Inoue, T. Takishima.
Protection against bradykinin-induced bronchoconstriction in asthmatic patients by
neurokinin receptor antagonist. Lancet 1992; 340: 1248-1251
29. M. Miura, M. Ichinose, K. Kimura, U. Katsumata, T. Takahashi, H. Inoue, T. Takishima.
Dysfunction of nonadrenergic noncholinergic inhibitory system after antigen inhalation in
actively sensitized cat airways. Am Rev Respir Dis 1992; 145: 70-74
30. M. Ichinose, K. Kimura, T. Takahashi, M. Miura, H. Inoue, T. Takishima, K. Shirato.
Antiasthma drug, ibudilast, inhibits neurogenic plasma extravasation in guinea-pig
airways. Am Rev Respir Dis 1993; 148: 431-434
31. T. Takahashi, M. Ichinose, H. Yamauchi, M. Miura, N. Nakajima, J. Ishikawa, H. Inoue,
T. Takishima, K. Shirato. Neuropeptide Y inhibits neurogenic inflammation in guinea pig
airways. J Appl Physiol 1993; 75: 103-107
32. T. Takahashi, M. Miura, U. Katsumata, M. Ichinose, K. Kimura, H. Inoue, T. Takishima,
K. Shirato. Involvement of superoxide in ozone-induced airway hyperresponsiveness in
anesthetized cats. Am Rev Respir Dis 1993; 148: 103-106

33. T. Izumiyama, W. Hida, M. Ichinose, H. Inoue, T. Takishima, T. Okazaki, K. Shirato.
Small airway involvement in mixed connective tissue disease. Tohoku J Exp Med 1993;
170: 273-283
34. N. Yamada, H. Inoue, H. Aratani, M. Ichinose, T. Takishima. Mechanisms of
bronchoconstriction after allergen ingestion in sensitized guinea pigs. Int Arch Allergy
Immunol 1993; 102: 295-300
35. M. Asano, H. Inoue, M. Ichinose, S. Okada, T. Takishima. Possible mechanisms of airway
hyperresponsiveness after late asthmatic response in guinea pigs. Int Arch Allergy
Immunol 1994; 103: 88-94
36. N. Nakajima, M. Ichinose, T. Takahashi, H. Yamauchi, A. Igarashi, M. Miura, H. Inoue,
T. Takishima, K. Shirato. Bradykinin-induced airway inflammation: contribution of
sensory neuropeptides differs according to airway site. Am J Respir Crit Care Med 1994;
149: 694-698
37. H. Yamauchi, M. Miura, M. Ichinose, J. Ishikawa, N. Nakajima, M. Tomaki, H. Inoue, K.
Maeyama, T. Watanabe, K. Shirato. Involvement of apamin-sensitive K + channels in
antigen-induced spasm of guinea-pig isolated trachea. Br J Pharmacol 1994; 112: 958-962
38. M. Ichinose, M. Miura, T. Takahashi, H. Yamauchi, N. Nakajima, A. Igarashi, J.
Ishikawa, H. Inoue, K. Maeyama, T. Watanabe, T. Takishima, K. Shirato.
Antigen-induced airway responses are inhibited by a potassium channel opener. Am J
Respir Crit Care Med 1994; 150: 388-393
39. J. Ishikawa, M. Ichinose, N. Nakajima T. Takahashi, H. Yamauchi, M. Miura, K. Shirato.
Potassium channel opener, YM 934, inhibits neurogenic plasma leakage in guinea pig
airways. Am J Respir Crit Care Med 1994: 150: 1379-1383
40. M. Tomaki, M. Ichinose, M. Miura, Y. Hirayama, H. Yamauchi, N. Nakajima, K. Shirato.
Elevated substance P content in induced sputum from patients with asthma and patients
with chronic bronchitis. Am J Respir Crit Care Med 1995; 151: 613-617
41. N. Kageyama, A. Igarashi, M. Ichinose, M. Miura, H. Yamauchi, M. Tomaki, J. Ishikawa,
Y. Sasaki, K. Shirato. Chronic allergen exposure enhances cholinergic neurotransmission
in sensitized guinea pigs. Eur Respir J 1995; 8: 752-754
42. M. Ichinose, M. Miura, T. Takahashi, N. Kageyama, M. Tomaki, N. Endoh, E. Sakurai, T.
Watanabe, K. Shirato. Airway allergic response and potassium channels: histamine
release and airway inflammation. Meth Find Exp Clin Pharmacol 1995; 17©: 36-39
43. M. Tomaki, M. Ichinose, M. Miura, Y. Hirayama, N. Kageyama, H. Yamauchi, K. Shirato.
Angiotensin converting enzyme (ACE) inhibitor-induced cough and substance P. Thorax
1996; 51: 199-201
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46. N. Kageyama, M. Ichinose, A. Igarashi, M. Miura, H. Yamauchi, Y. Sasaki, J. Ishikawa,
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66. M. Ichinose. Inflammatory mechanisms in bronchial asthma and COPD. Tohoku J Exp
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68. T. Takahashi, M. Ichinose, H. Inoue, K. Shirato, T. Hattori, T. Takishima. Underdiagnosis
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69. H. Sugiura, M. Ichinose, M. Tomaki, H. Ogawa, A. Koarai, T. Kitamuro, Y. Komaki, T.
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70. K. Yukawa, K. Hoshino, M. Kishino, M. Mune, N. Shirasawa, A. Kimura, Y. Tsubota, K.
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71. M. Nara, K. Sasamori, S. Shimura, H. Ogawa, S. Suzuki, M. Nagaoka, M. Ichinose, G.
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72. M. Ichinose, Peter J Barnes. Cytokine-directed therapy in asthma. Current Drug
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73. M. Kishino, K. Yukawa, K. Hoshino, A. Kimura, N. Shirasawa, H. Otani, T. Tanaka, K.
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74. K. Matsunaga, M. Ichinose. Effect of a leukotriene receptor antagonist on prevention of
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75. Y. Fukuchi, M. Nishimura, M Ichinose, M. Adachi, A. Nagai, T. Kuriyama, K. Takahashi,
K. Nishimura, S. Ishioka, H. Aizawa, A. Iqbal. Chronic obstructive pulmonary disease
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76. K. Yukawa, K. Hoshino, M. Kishino, M. Mune, N. Shirasawa, A. Kimura, Y. Tsubota, K.
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77. T. Yamagata, Y. Yamagata, M. Nakanishi, K. Matsunaga, Y. Minakata, M. Ichinose. A
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78. T. Yamagata, Y. Okamoto, Y. Yamagata, M. Nakanishi, K. Matsunaga, Y. Minakata, M.
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79. K. Yukawa, K. Hoshino, M. Kishino, M. Mune, N. Shirasawa, A. Kimura, Y. Tsubota, K.
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81. K. Owada-Makabe, Y. Tsubota, K. Yukawa, N. Kakimoto, X.M. Liang, M. Ichinose, M.
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82. Y. Komaki, H. Sugiura, A. Koarai, M. Tomaki, H. Ogawa, T. Akita, T. Hattori, M.
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85. H. Tanaka, H. Tujioka, H. Ueda, H. Hamagami, Y. Kida, M. Ichinose. Autoimmune
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86. H. Ueda, H. Hamagami, H. Tanaka, Y. Kida, M. Ichinose. Combination hepatic arterial
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87. H. Tanaka, M. Miyano, H. Ueda, K. Fukui, M. Ichinose. Changes in serum and red blood
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88. Y. Fukuchi, A. Nagai, K. Seyama, M. Nishimura, K. Hirata, K. Kubo, M. Ichinose, H.
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Tulobuterol in the Treatment of Stable COPD: An Open-Label Comparison with Inhaled
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89. T. Yamagata, M. Ichinose. Agents against cytokine synthesis or receptors. Eur J
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90. M. Nara, K. Sano, H. Ogawa, T. Tamada, M. Nagaoka, K. Okada, M. Watanabe, T.
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91. H. Tanaka, H. Ueda, Y. Kida, H. Hamagami, T. Tsuji, M. Ichinose. Hepatic
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92. K. Matsunaga, S. Yanagisawa, T. Ichikawa, K. Ueshima, K. Akamatsu, T. Hirano, M.
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95. H. Tanaka, S. Maeshima, Y. Shigekawa, H. Ueda, H. Hamagami, Y. Kida, M. Ichinose.
Neuropsycholo impairment and decresed patients with chronc hepatitis: a preliminary
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96. K. Matsunaga, T. Yamagata, Y. Minakata, M. Ichinose. Importance of assistance by
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97. Y. Kida, S. Tsuji-Kawahara, V. Ostapenko, S. Kinoshita, E. Kajiwara, H. Kawabata, T.
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98. M. Ichinose. Advances in Pharmacotherapy for COPD. Intern Med 2007; 46: 81-84
99. H. Tanaka, S. Maeshima, H. Ueda, Y. Shigekawa, H. Fukuchi, Y. Kida, M. Ichinose.
Reduction of Regional Cerebral Blood Flow of Patients with Liver Cirrhosis and its
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100. K. Ueshima, Y. Minakata, H. Sugiura, S. Yanagisawa, T. Ichikawa, K. Akamatsu, T.
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101. M. Tomaki, H. Sugiura, A. Koarai, Y. Komaki, T. Akita, T. Matsumoto, A. Nakanishi, H.
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102. T. Yamagata, H. Sugiura, T. Yokoyama, S. Yanagisawa, T. Ichikawa, K. Ueshima, K.
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103. K. Akamatsu, T. Yamagata, T. Takahashi, K. Miura, S. Maeda, Y. Yamagata, T.
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104. T. Ichikawa, K. Matsunaga, Y. Minakata, S. Yanagisawa, K. Ueshima, K. Akamatsu, T.
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105. Y. Kida, H. Ueda, H. Tanaka, M. Ichinose. Estimated protein intake by urinary urea
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106. Y. Kida, E. Maeshima, K. Furukawa, T. Ichikawa, M. Goda, M. Ichinose. A case of
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Mod Rheumatol 2007; 17: 262-264
107. T. Yamagata, T. Hirano, H. Sugiura, S. Yanagisawa, T. Ichikawa, K. Ueshima, K.
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108. Y. Minakata, H. Sugiura, T. Yamagata, S. Yanagisawa, T. Ichikawa, A. Koarai, K.
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Clinics: Correlation with Non-Respiratory Diseases. Intern Med 2008; 47: 77-82
109. Y. Minakata, H. Iijima, T. Takahashi, M. Miura, H. Ogawa, K. Kimura, T. Koga, M.
Kinoshita, T. Tsuda, H. Aizawa, M. Ichinose. Efficacy and Safety of Formoterol in
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110. H. Sugiura, M. Ichinose. Oxidative and nitrative stress in bronchial asthma. Antioxid
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111. H. Sugiura, Y. Komaki, A. Koarai, M. Ichinose. Nitrative stress in refractory asthma. J
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112. H. Tanaka, H. Ueda, Y. Kida, H. Fukuchi, M. Ichinose. Rapid intrahepatic tumor seeding
after percutaneous ethanol injection therapy for hepatocellular carcinoma. Intern
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113. H. Ueda, H. Tanaka, Y. Kida, H. Fukuchi, M. Ichinose. Adjuvant chemotherapy with
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advanced hepatocellular carcinoma. Oncol Rep 2008; 19: 1355-1361
114. T. Kawayama, Y. Minakata, K. Matsunaga, T. Yamagata, T. Tsuda, M. Kinoshita, T.
Iwanaga, M. Ichinose, H. Aizawa. Validation of symptom-based COPD questionnaires in
Japanese subjects. Respirology 2008; 13: 420-426
115. K. Matsunaga, M. Kanda, A. Hayata, S. Yanagisawa, T. Ichikawa, K. Akamatsu, A.
Koarai, T. Hirano, H. Sugiura, Y. Minakata, M. Ichinose. Peak Expiratory Flow
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116. K. Akamatsu, T. Yamagata, Y. Kida, H. Tanaka, H. Ueda, M. Ichinose. Poor Sensitivity of
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117. T. Ichikawa, H. Sugiura, A. Koarai, S. Yanagisawa, M. Kanda, A. Hayata, K. Furukawa,
K. Akamatsu, T. Hirano, M. Nakanishi, K. Matsunaga, Y. Minakata, M. Ichinose.
Peroxynitrite augments fibroblast-mediated tissue remodeling via myofibroblast
differentiation. Am J Physiol Lung Cell Mol Physiol 2008; 295: 800-808
118. S. Yanagisawa, H. Sugiura, T. Yokoyama, T. Yamagata, T. Ichikawa, K. Akamatsu, A.
Koarai, T. Hirano, M. Nakanishi, K. Matsunaga, Y. Minakata, M. Ichinose. The possible
role of hematopoietic cell kinase in the pathophysiology of chironic obstructive pulmonary
disease. Chest 2009; 135: 94-101
119. T. Yamagata, Y. Yamagata, T. Nishimoto, T. Hirano, M. Nakanishi, Y. Minakata,
M.Ichinose, A. Dagenais, Y. Berthiaume. The regulation of amiloride-sensitive epithelial
sodium channels by tumor necrosis factor-alpha in injured lungs and alveolar type II cells.
Respir Physiol Neurobiol 2009; 166: 16-23
120. K. Matsunaga, S. Yanagisawa, T. Ichikawa, K. Akamatsu, A. Koarai, T. Hirano, H.
Sugiura, Y. Minakata, M. Ichinose . Molecular Mechanism of the Additive Effects of
Leukotriene Modifier in Asthmatic Patients Receiving Steroid Therapy. Allergol Int 2009;
58: 89-96
121. H. Tanaka, H. Ueda, H. Fukuchi, M. Ichinose: Antifibrotic effect of edaravone in rat liver
cirrhosis induced by dimethylnitrosamine. Clin Exp Med. 2009; 9: 229-233
122. M. Nagaoka, M. Nara, Tamada, Kume H, Oguma T, Kikuchi T, Zaini J, MoriyaT, M.
Ichinose, Tamura G, Hattori T. Regulation of adenosine 5’-triphosphate (ATP)-gated P2X₄
receptors on tracheal smooth muscle cells. Respir Physiol Neurobiol 2009 ; 166: 61-67
123. H. Sugiura, T. Ichikawa, A. Koarai, S. Yanagisawa, Y. Minakata, K. Matsunaga, T Hirano, K.
Akamatsu, M. Ichinose. Activation of Toll-Like Receptor 3 Augments Myofibroblast Differentiation.
Am J Respir Cell Mol Biol 2009; 40: 654-662
124. M. Ichinose. Differences of inflammatory Mechanisms in Asthma and COPD. Allergol Int
2009; 58: 307-313
125. S. Yanagisawa, A. Koarai, H. Sugiura, T. Ichikawa, M. Kanda, R. Tanaka, K. Akamatsu,
T. Hirano, K. Matsunaga, Y. Minakata, M. Ichinose. Oxidative stress augments toll-like
receptor 8 mediated neutrophilic responses in healthy subjects. Respir Res 2009; 10: 50
126. K. Furukawa, E. Maeshima, S. Maeshima, M. Ichinose. Multiple symptoms of higher
brain dysfunction caused by Marchiafava-Bignami disease in a patient with
dermatomyositis. Rheumatol Int 2009 Oct 22. Epub ahead of print
127. K. Matsunaga, T. Ichikawa, S. Yanagisawa, K. Akamatsu, A. Koarai, T. Hirano, H.
Sugiura, Y. Minakata, M. Ichinose. Clinical Application of Exhaled Breath Condensate
Analysis in Asthma: Prediction of FEV₁ Improvement by Steroid Therapy. Respiration
2009; 78: 393-398
128. H. Sugiura, T. Ichikawa, X. Liu, T. Kobayashi, XQ. Wang S. Kawasaki, S. Togo, K. Kamio,
K. Mao, Y. Ann, M. Ichinose, SI. Rennard. N-acetyl-L-cysteine inhibits TGF-β₁-induced
profibrotic responses in fibroblasts. Pulm Pharma Ther 2009; 22: 487-491
129. H. Sugiura, X. Liu, T. Ichikawa, M. Ichinose, SI. Rennard. 3-Nitrotyrosine inhibits
fibroblast-mediated collagen gel contraction and chemotaxis. Eur Respir J 2009; 34:
1452-1460

130. A. Koarai, H. Sugiura, S. Yanagisawa, T. Ichikawa, Y. Minakata, T. Hirano, K. Akamatsu,
M. Ichinose. Oxidative Stress Enhances Toll-like Receptor 3 Response to Double-stranded
RNA in Airway Epithelial Cells. Am J Respir Cell Mol Biol 2010; 42: 651-660
131. M. Ichinose, T. Fujimoto, Y. Fukuchi. Tiotropium 5 µg via Respimat and 18µg via
HandiHaler; efficacy and safety in Japanese COPD patients. Respir Med 2010; 104:
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132. M. Ichinose, K. Seyama, M. Nishimura, Y. Fukuchi, A. Nagai, M. Mishima, K. Kubo, for
the Beta-2 Agonist Research and Evaluation Committee in COPD (BAREC) Study Group.
Additive effects of transdermal tulobuterol to inhaled tiotropium in patients with COPD.
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5. M. Ichinose. Antiallergic drugs. D Spina, C.P. Page, W.J. Metzger, B.J. O’Connor editors.
Drugs for the Treatment of Respiratory Diseases. Cambridge University Press,
Cambridge, 2003; p119-p123

Brief CV
Prof. David Shu-Cheong Hui
Education/Training: MBBS (UNSW, Australia)1985; MRCP (UK)1991; FRACP 1994;
FCCP 1995; FHKCP 1998; FHKAM(Medicine)1998; FRCP (Lond, Edin, Glasg) 2002;
MD (UNSW, Australia)2002.
Trained in Respiratory Medicine at the Prince of Wales Hospital, Sydney (1993-1995) and
Sleep Medicine at the Sleep Disorders Center, Royal Prince Alfred Hospital, Sydney (1995-
1997).
Positions:
Professor & Head of Division of Respiratory Medicine, The Chinese University of Hong Kong.
Honorary Consultant Respiratory Physician, Dept of Medicine & Therapeutics, Prince of
Wales Hospital, Shatin, HK.
Senior Associate Editor for Respirology and Deputy Editor for Sleep
Executive Committee member for the GOLD (Global Initiative for Chronic Obstructive
Lung Diseases) Committee since May 2008.
Publications: >180 peer-reviewed full papers (published and in press); 21 book chapters

Curriculum Vitae
Name Dr Ian M Adcock
Designation: Professor of Respiratory Cell and Molecular Biology
Address, Guy Scadding Building,
National Heart & Lung Institute
Imperial College London
Dovehouse Street
London SW3 6LY
Telephone: +44 (0)207 351 8878
Fax: +44 (0)207 351 8126
E-mail: ian.adcock@imperial.ac.uk
Educational Qualifications:
1980-1983. B.Sc. (2.i) in Biochemistry/Physiology, Bedford College, University of London.
1983-1986. Ph.D. Studentship, Dept. Pharmacology, UMDS, London.
2010: Fellow of the Society of Biologists
Research/Training Experience
1986-87 Post-doctoral Fellow, MRC Brain Metabolism Unit, Edinburgh.
1987-90 Post-doctoral Fellow, St George’s Hospital Medical School, London
1990-93 Post-doctoral Fellow, Thoracic Medicine, NHLI, London
1993-98 Lecturer, Thoracic Medicine, NHLI, London
1998-00 Senior Lecturer, Airways Disease Section, NHLI, Imperial College
2000-04 Reader, Airways Disease Section, NHLI, Imperial College
2004-on Professor of Respiratory Cell & Molecular Biology
Measures of Esteem
Member ERS/ATS Task Force on Severe Asthma
Member ERS/ATS Task Force on Outcomes in COPD Clinical Trials
Member GMEC in Respiratory Disease
PI MRC/Asthma UK Centre in Asthma and Allergic Diseases
PI Wellcome Trust Centre for Infectious Diseases
PI Biomedical Research Unit (BRU) in COPD at RBH
Member of the MRC Advisory Board (2003-2004).
Member of the MRC College of Experts (2002-2009).
Member of NIH Asthma Centre Review Panel 2007.
Asthma UK Research Grants Committee (2001 – 2004).
Clinical Research Committee Royal Brompton Hospital (1997 – present).
Current Head Airway Pharmacology in the ERS, Member ERS Council (2005-2008)
Secretary ERS Assembly 5 (Airways Diseases) 2011-2013.

Editorial Board Membership: Respiratory Research, Journal of Inflammation, European Journal
of Pharmacology, Drug Discovery Today, Journal of Pharmacology & Experimental
Therapeutics and Therapeutic Advances in Respiratory Disease.
Research Funding
Asthma UK, Expression Profiling of glucorcorticoid effects in microdissected primary human
airway epithelial cells and smooth muscle tissue, £120,937
MRC, Role of oxidative and nitrosative stress and histone deacetylation in RV-induced acute
exacerbations in COPD, £1,200,000
MRC, Reversal of corticosteroid insensitivity in COPD by theophylline, £600, 000
MRC, Glucocorticoid receptor, acetylation and corticosteroid resistance in chronic obstructive
pulmonary disease, £284,140
MRC, Regulation of IL-13 Transcription in Human T-Cells by GATA-3/NFAT complexes:
modulation by corticosteroids, £468,988.
Royal Society, Action of the Adenosine A3 Receptor Ligand CI-IB-MECA in Dendritic Cells,
£12,000
EU-IMI, Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (UBIOPRED),
£826, 425
BBSRC, The role of PI3K and GSK3 in steroid insensitivity in COPD, £79, 000
Asthma UK, Global analysis of GR DNA binding in severe asthma, £49, 500
EPSRC, Improved inhibition of HDAC2 by modification of curcumin, £84, 000
MRC, MIF function in COPD, £79, 500
MRC Capacity Award Studentship, Non-NF-B-driven mechanisms of inflammation in severe
COPD, £74, 000
MRC, MRC-ABPI initiative - Innate immunity and fibrosis, £289, 799
Wellcome Trust, Role of histone deacetylase-2 in the regulation of inflammation and
corticosteroid sensitivity in COPD, £796,085
Wellcome Trust, Role of acetylation and methylation in COPD, £975,642
Pfizer, Understanding inflammatory mechanisms and steroid resistance in COPD, £2,100,000
GSK, The role of Wnt4 in COPD, £40, 000
GSK, The effect of combination therapy on B-cell function in COPD, £40, 000
Recent Publications (out of >260)
1. Caramori G et al., Unbalanced oxidant-induced DNA damage and repair in COPD: a link
towards lung cancer. Thorax. 2011 Apr 2. [Epub ahead of print] PubMed PMID:
21460372.
2. Adcock IM et al., Chronic obstructive pulmonary disease and lung cancer: new molecular
insights. Respiration. 2011;81(4):265-84.
3. Sorrentino R et al., B Cells contribute to the Anti-tumour Activity of CpG-ODN in a Mouse
Model of Metastatic Lung Carcinoma. Am J Respir Crit Care Med. 2011 Jan 28. [Epub
ahead of print] PubMed PMID: 21278302.
4. Varani K et al., Oxidative/nitrosative stress selectively altered A(2B) adenosine
receptors in chronic obstructive pulmonary disease. FASEB J. 2010 Apr;24(4):1192-204.
5. Price LC et al., Dexamethasone reverses monocrotaline-induced pulmonary arterial
hypertension in rats. Eur Respir J. 2011 Apr;37(4):813-22.

6. Auffray C et al,, An integrative systems biology approach to understanding pulmonary
diseases. Chest. 2010 Jun;137(6):1410-6.
7. Kirkham PA et al., Serum autoantibodies anti-carbonylated proteins correlate with
severity of stable COPD. Am J Respir Crit Care Med (In Press).
8. Sorrentino R et al., Plasmacytoid dendritic cells alter the antitumor activity of
CpG-oligodeoxynucleotides in a mouse model of lung carcinoma. J Immunol. 2010;
185(8):4641-50.
9. Sorrentino R et al., CpG-ODN increases the release of VEGF in a mouse model of lung
carcinoma. Int J Cancer. 2010 Aug 19. [Epub ahead of print] PubMed PMID: 20725994.
10. Marwick JA et al., A role for phosphoinositol 3-kinase delta in the impairment of
glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease. J
Allergy Clin Immunol. 2010 May;125(5):1146-53.
11. Ford PA et al., Treatment effects of low-dose theophylline combined with an inhaled
corticosteroid in COPD. Chest. 2010 Jun;137(6):1338-44.
12. Charron CE et al., Hypoxia-inducible factor 1alpha induces corticosteroid-insensitive
inflammation via reduction of histone deacetylase-2 transcription. J Biol Chem. 2009
Dec 25;284(52):36047-54.
13. Mortaz E et al., Cigarette smoke induces CXCL8 production by human neutrophils via
activation of TLR9 receptor. Eur Respir J. 2010 Apr 22. [Epub ahead of print].
14. Di Stefano A et al., Association of increased CCL5 and CXCL7 chemokine expression with
neutrophil activation in severe stable COPD. Thorax. 2009 Nov;64(11):968-75.
15. Di Stefano A et al., T helper type 17-related cytokine expression is increased in the
bronchial mucosa of stable chronic obstructive pulmonary disease patients. Clin Exp
Immunol. 2009; 157(2):316-24.
16. Wort SJ et al., Synergistic induction of endothelin-1 by tumor necrosis factor alpha and
interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at
specific kappaB sites. J Biol Chem. 2009 Sep 4;284(36):24297-305.
17. Ho SC et al., Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth
muscle cells through induction of NF-B repressing factor. J Immunol. 2009;
183(1):411-20.
18. Williams AE et al., MicroRNA expression profiling in mild asthmatic human airways and
effect of corticosteroid therapy. PLoS One. 2009; 4(6):e5889.
19. Barnes PJ, Adcock IM. Glucocorticoid resistance in inflammatory diseases. Lancet. 2009;
373(9678):1905-17.
20. Maneechotesuwan K et al., Suppression of GATA-3 nuclear import and phosphorylation: a
novel mechanism of corticosteroid action in allergic disease. PLoS Med. 2009;
6(5):e1000076.
21. Osoata GO et al., Nitration of distinct tyrosine residues causes inactivation of histone
deacetylase 2. Biochem Biophys Res Commun. 2009; 384(3):366-71.
22. Marwick JA et al., Inhibition of PI3K restores glucocorticoid function in smoking-induced
airway inflammation in mice. Am J Respir Crit Care Med. 2009; 179(7):542-8.
23. Adcock IM et al., New targets for drug development in asthma. Lancet. 2008;
372(9643):1073-87.
24. Bhavsar P et al., Relative corticosteroid insensitivity of alveolar macrophages in severe
asthma compared with non-severe asthma. Thorax. 2008; 63(9):784-90.

25. Maneechotesuwan K et al., Loss of control of asthma following inhaled corticosteroid
withdrawal is associated with increased sputum interleukin-8 and neutrophils. Chest.
2007; 132:98-105.
26. Issa R et al., Corticosteroid inhibition of growth-related oncogene protein-alpha via
mitogen-activated kinase phosphatase-1 in airway smooth muscle cells. J Immunol.
2007; 178:7366-75.
27. Williams AS et al., Attenuation of ozone-induced airway inflammation and
hyper-responsiveness by c-Jun NH2 terminal kinase inhibitor SP600125. J Pharmacol
Exp Ther. 2007; 322:351-9.
28. Maneechotesuwan K et al., Regulation of Th2 cytokine genes by p38 MAPK-mediated
phosphorylation of GATA-3. J Immunol. 2007; 178:2491-8.
29. Vasavda N et al., Expression of nonmuscle cofilin-1 and steroid responsiveness in severe
asthma. J Allergy Clin Immunol. 2006; 118:1090-6.
30. Morello S et al., IL-1 and TNF- regulation of the adenosine receptor (A2A) expression:
differential requirement for NF-B binding to the proximal promoter. J Immunol. 2006;
177:7173-83.
31. Hew M et al., Relative corticosteroid insensitivity of peripheral blood mononuclear cells in
severe asthma. Am J Respir Crit Care Med. 2006; 174:134-41.
32. Ito K et al., Update on glucocorticoid action and resistance. J Allergy Clin Immunol.
2006; 117:522-43.
33. Ito K et al., Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor
enables NF-B suppression. J Exp Med. 2006; 203:7-13.
34. Lee KY et al., NF-B and activator protein 1 response elements and the role of histone
modifications in IL-1-induced TGF-1 gene transcription. J Immunol. 2006;
176:603-15.
35. Varani K et al., Alteration of adenosine receptors in patients with chronic obstructive
pulmonary disease. Am J Respir Crit Care Med. 2006; 173:398-406.
36. Ricciardolo FL et al., Nitrosative stress in the bronchial mucosa of severe chronic
obstructive pulmonary disease. J Allergy Clin Immunol. 2005; 116:1028-35.
37. Maneechotesuwan K et al., Formoterol attenuates neutrophilic airway inflammation in
asthma. Chest. 2005; 128:1936-42.
38. Ito K et al., Decreased histone deacetylase activity in chronic obstructive pulmonary
disease. N Engl J Med. 2005; 352:1967-76.
39. Usmani OS et al., Glucocorticoid receptor nuclear translocation in airway cells after inhaled
combination therapy. Am J Respir Crit Care Med. 2005; 172:704-12.
40. Cosio BG et al., Theophylline restores histone deacetylase activity and steroid responses in
COPD macrophages. J Exp Med. 2004; 200:689-95.
41. Matthews JG et al., Defective glucocorticoid receptor nuclear translocation and altered
histone acetylation patterns in glucocorticoid-resistant patients. J Allergy Clin Immunol.
2004; 113:1100-8.
42. Eynott PR et al., Allergen-induced inflammation and airway epithelial and smooth muscle
cell proliferation: role of Jun N-terminal kinase. Br J Pharmacol. 2003; 140:1373-80.
43. Allen M et al., Positional cloning of a novel gene influencing asthma from chromosome
2q14. Nat Genet. 2003; 35:258-63.

44. Zhang Y et al., Positional cloning of a quantitative trait locus on chromosome 13q14 that
influences immunoglobulin E levels and asthma. Nat Genet. 2003; 34:181-6.
45. Caramori G et al., Nuclear localisation of p65 in sputum macrophages but not in sputum
neutrophils during COPD exacerbations. Thorax. 2003; 58:348-51.
46. Gusterson RJ et al., The transcriptional co-activators CREB-binding protein (CBP) and p300
play a critical role in cardiac hypertrophy that is dependent on their histone
acetyltransferase activity. J Biol Chem. 2003; 278:6838-47.
47. de Haij S et al., Steroid responsiveness of renal epithelial cells. Dissociation of
transrepression and transactivation. J Biol Chem. 2003; 278:5091-8.
48. Tomita K et al., Increased p21(CIP1/WAF1) and B cell lymphoma leukemia-x(L) expression
and reduced apoptosis in alveolar macrophages from smokers. Am J Respir Crit Care
Med. 2002; 166:724-31.
49. Ito K et al., A molecular mechanism of action of theophylline: Induction of histone
deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S
A. 2002; 99:8921-6.
50. Irusen E et al., p38 Mitogen-activated protein kinase-induced glucocorticoid receptor
phosphorylation reduces its activity: role in steroid-insensitive asthma. J Allergy Clin
Immunol. 2002; 109:649-57.
51. Payne DN et al., Relationship between exhaled nitric oxide and mucosal eosinophilic
inflammation in children with difficult asthma, after treatment with oral prednisolone. Am
J Respir Crit Care Med. 2001; 164:1376-81.
52. Ito K et al., Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits
interleukin-1-induced histone H4 acetylation on lysines 8 and 12. Mol Cell Biol. 2000;
20:6891-903.
53. Finney PA et al., Albuterol-induced downregulation of Gs accounts for pulmonary
2-adrenoceptor desensitization in vivo. J Clin Invest. 2000; 106:125-35.
54. Lane SJ et al., Corticosteroid-resistant bronchial asthma is associated with increased c-fos
expression in monocytes and T lymphocytes. J Clin Invest. 1998; 102:2156-64.
55. Adcock IM et al., Glucocorticoid receptor localization in normal and asthmatic lung. Am J
Respir Crit Care Med. 1996; 154:771-82.
56. Adcock IM et al., Abnormal glucocorticoid receptor-activator protein 1 interaction in
steroid-resistant asthma. J Exp Med. 1995; 182:1951-8.
57. Adcock IM et al., Differences in binding of glucocorticoid receptor to DNA in
steroid-resistant asthma. J Immunol. 1995; 154:3500-5.

MARC LENBURG
Curriculum Vitae
Current Position: Associate Professor of Medicine
Section of Computational Biomedicine
Boston University School of Medicine
72 East Concord Street, E728
Boston, MA 02118
mlenburg@bu.edu
(617) 414-1375
Professional Experience:
2010 – present Associate Professor of Medicine, Section of Computational Biomedicine,
Boston University School of Medicine.
2008 – present Associate Professor, Bioinformatics Program, Boston University College
of Engineering.
2008 – present Associate Professor, Pulmonary Center, Boston University School of
Medicine.
2008 – present Associate Professor of Pathology and Laboratory Medicine, Boston
University School of Medicine.
2007 – 2011 Visiting Scientist, Lawrence Berkeley National Laboratory
2008 Associate Professor of Genetics and Genomics, Boston University School
of Medicine.
2007 – 2008 Assistant Professor, Pulmonary Center, Boston University School of
Medicine.
2007 – 2008 Assistant Professor, Bioinformatics Program, Boston University College of
Engineering.
2003 – 2008 Research Assistant Professor of Genetics and Genomics,
Boston University School of Medicine.
1992 – 1993 Research Associate, Aaron Diamond AIDS Foundation, NY, NY.
1991 – 1992 Research Associate, Progenics Pharmaceuticals, Inc. Tarrytown, NY
Education:
2000 Ph.D., Biochemistry, University of California at San Francisco
1990 B.A., Biology, Wesleyan University, Middletown, CT. University Honors
(summa cum laude).
Honors:
1994 – 1999 Predoctoral Fellow, Howard Hughes Medical Institute
1993 – 1994 Predoctoral Fellow, National Science Foundation
1990 – 1991 Ford Foundation Fellow

1990 University Honors (summa cum laude), Wesleyan University
1990 Seldon Brown Scholar
1989 Robert Newell Scholar
1988 Phi Beta Kappa
Boston University Departmental / Institutional Service:
2008 – Present Deputy Director, Translational Bioinformatics Core, Clinical &
Translational Science Institute.
2008 – Present Member, Department of Medicine Information Advisory Group.
2008 – Present Member, LinGA Advisory Committee.
2008 – Present Member, Computational Resources Committee, Genome Sciences
Institute.
2008 – Present Member, Graduate Admissions Committee, Graduate Program in
Genetics & Genomics
2002 – Present Co-Director, Microarray Resource, Boston University School of Medicine.
2008 – 2010 Member, Bioinformatics Faculty Search Committee, Department of
Medicine
2008 – 2009 Co-Chair, Institutional IT Strategic Planning Taskforce, Boston University
Medical Campus.
2008 – 2009 Member, Institutional IT Strategic Planning Taskforce, Research IT
subcommittee.
2007 Chair, Microarray Resource Core Director Search Committee
2007 Member, Russek Student Achievement Day, Departmental Selection
Committee
2002 – 2007 Director of Bio-Information Technology, Department of Genetics and
Genomics.
2003 – 2006 Member, Graduate Admissions Committee, Department of Genetics &
Genomics
Extramural Service:
2010 – present NCI Early Detection Research Network: Informatics Subcommittee
2010 – present Reviewer, NCI Early Detection Research Network: Lung Cancer Tissue
Repository Access Committee
2009 – present Reviewer, PA DOH Master Tobacco Settlement Grant Program
2008 – present I-SPY2 Biomarker Committee.
2008 – present NIH/NHLBI MP7 Molecular Phenotypes of Lung Disease Bioinformatics
Working Group.
2007 – present I-SPY TRIAL Data and Publications Committee.
2007 – present Informed Consent Oversight Board, Coriell Institute for Medical Research.
2011 Chair, ATS International Conference Discussion Session: ‘Omics
Approaches to Lung Disease
2011 Reviewer, Neuron
2010 Reviewer, Bioinformatics
2010 Ad hoc member, NIH Center for Scientific Review, Epidemiology of
Cancer (EPIC) Study Section.
2010 Chair, ATS Annual Meeting Poster Session: Functional Genomics
2

2010 Reviewer, Public Library of Science (PLoS)
2010 Proposal Planning Committee. UCOP Tobacco-Related Disease
Research Program, Lung Cancer Early Detection Initiative.
2010 Reviewer, Netherlands Asthma Foundation
2009 Reviewer, Cancer Research.
2009 Reviewer, Clinical Cancer Research.
2009 NIH/NIAID Special Emphasis Panel: Clinical Trials in Organ
Transplantaion U01 RFA AI-08-015.
2006 Ad-hoc reviewer, Civilian Research and Development Foundation, Basic
Research and Higher Education Post-Doctoral Fellowship Program.
Scientific Advisory Activities:
2009 – present Scientific Advisor, Eden Therapeutics, Inc., San Diego, CA.
2007 – present Scientific Advisor, Allegro Diagnostics, Inc., Boston, MA.
Professional Memberships:
2009 – present American Thoracic Society
2008 – present Society for Clinical and Translational Science
2007 – present American Association for Cancer Research
2002 – present International Society of Computational Biology
2002 – present American Association for the Advancement of Science
Teaching Activities:
2008 – present Lecturer, GMS PA 801, Introduction to Basic and Applied Pathology
2008 – present Lecturer, GMS PM 832, Pharmacogenomics
2005 – present Lecturer, GMS GE 702, Advanced Topics in Genetics and Genomics
2004 – present Guest Lecturer, ENG BE 565, Molecular Biotechnology
2003 – present Lecturer, GMS GE 701, Principles of Genetics and Genomics
2008 – 2009 Mentor, ENG BF 900, IGERT Challenge Project
2008 Guest Lecturer, Pathology Residents Conference
2005 Mentor, GMS GE 703, Genetics and Genomics Colloquium
2005 Mentor, CAS BB 392, Undergraduate Research
Junior Faculty Mentoring:
2011 – present Jennifer Beane, Ph.D., Assistant Professor of Medicine, Section of
Computational Biomedicine
2010 – present Katrina Steiling, M.D., Assistant Professor of Medicine, Section of
Computational Biomedicine
2009 – present Christina Anderlind, M.D., Instructor of Medicine, Section of
Computational Biomedicine
2007 – present Yuriy Alekseyev, Ph.D., Research Assistant Professor of Pathology and
3

Laboratory Medicine
2009 – 2010 Steven Shen, M.D., Research Assistant Professor of Medicine. Current
position: Adjunct Associate Professor of Medicine, New York University
2005 – 2007 Karen Schlauch, Ph.D., Research Assistant Professor of Genetics and
Genomics. Current position: Associate Professor, University of Nevada
at Reno.
2003 – 2007 Norman Gerry, Ph.D., Research Assistant Professor of Genetics and
Genomics. Current position: Associate Professor, Coriell Institute for
Medical Research.
Fellow Mentoring:
2010 – present Charles Dumont, M.D., Fellow, Department of Medicine, Section of
Computational Biomedicine
2009 – present Yannbor Lin, M.D., Fellow, Department of Medicine, Section of
Computational Biomedicine
2008 – present Bozena Malysko, M.D., Fellow, Pulmonary Center.
2007 – 2011 Jennifer Beane, Ph.D., Post-Doctoral Fellow, Pulmonary Center. Current
position: Assistant Professor of Medicine, Section of Computational
Biomedicine, Boston University School of Medicine.
2009 – 2010 Henk Kramer, M.D., Visiting Fellow Pulmonary Center. Current position:
Assistant Professor. Department of Pulmonology, University Medical
Center, Groningen, The Netherlands.
2009 – 2010 Maarten van den Berge, M.D., Visiting Fellow Pulmonary Center. Current
position: Assistant Professor. Department of Pulmonology, University
Medical Center, Groningen, The Netherlands.
2007 – 2010 Christina Anderlind, M.D., Fellow, Pulmonary Center. Current position:
Instructor of Medicine, Section of Computational Biomedicine, Boston
University School of Medicine.
2007 – 2010 Stephanie Christenson, M.D,, Internal Medicine Resident. Current
position: Pulmonary Fellow, University of California at San Francisco
2006 – 2010 Katrina Steiling, M.D., Fellow, Pulmonary Center. Current position:
Assistant Professor of Medicine, Section of Computational Biomedicine,
Boston University School of Medicine.
Student Mentoring:
2010 – present Kahkeshan Hijazi, Bioinformatics Program
2010 – present Rebecca Kusko, Genetics and Genomics Graduate Program
2009 – present Joseph Gerrein, Bioinformatics Program
2008 – present John Brothers, Bioinformatics Program
2008 – present Joshua Campbell, Bioinformatics Program
2007 – present Adam Gower, Bioinformatics Program
2007 – present Julie Zeskind, Bioinformatics Program
2007 – 2009 Xiaoling Zhang, Bioinformatics Program. Current position: Post-doctoral
fellow, NHLBI.
2005 – 2009 Adam Gustafson, Bioinformatics Program. Current position: Consultant
2005 -- 2008 Sriram Sridhar, Pathology and Laboratory Medicine. Current position:
4

Bioinformatics Scientist, Roche, Inc.
2005 – 2007 Jennifer Beane, Bioinformatics Program. Current position: Assistant
Professor of Medicine, Section of Computational Biomedicine, Boston
University School of Medicine.
2004 – 2005 Olga Novikov, Undergraduate Research Opportunity Program (UROP),
Dept. of Biology. Current position: Medical Student, Boston University
School of Medicine.
Student Mentoring (Rotation Projects):
2011 Scott Mottarella, Bioinformatics Program
2011 Yuxiang Tan, Bioinformatics Program
2010 Teresa Wang, Bioinformatics Program
2010 Rebecca Kusko, Genetics and Genomics
2009 – 2010 Yevgeniy Gindin, Bioinformatics Program
2007 Adam Gower, Bioinformatics Program
2005 Eric Bishop, Bioinformatics Program
2004 Adam Gustafson, Bioinformatics Program
2004 Evan Snitkin, Bioinformatics Program
Student Evaluation / Examining Activities:
2010 – present Chair, Thesis Committee, Catalina Perdomo, Genetics and Genomics
2011 Chair, Doctoral Qualifying Committee, Kahkeshan Hijazi, Bioinformatics
2010 Masters Thesis Reader, Rachel Grimes, BMS
2009 Doctoral Qualifying Committee, Adam Gower, Bioinformatics
2009 Doctoral Qualifying Committee, Julie Zeskind, Bioinformatics
2009 Thesis Reader, Tovah Day, Genetics and Genomics
2008 – 2009 Thesis Committee, Tovah Day, Genetics and Genomics. Current
position: Post-doctoral fellow, David Weinstock, Dana-Farber Cancer
Institute
2008 – 2009 Thesis Committee, Ihn-Young Song, Genetics and Genomics. Current
position: Post-doctoral fellow, Alan Balmain, University of California at
San Francisco
2007 – 2009 Chair, Thesis Committee, Kelly Graham, Genetics and Genomics.
Current position: Post-doctoral fellow, University of Buffalo
2007 – 2008 Chair, Thesis Committee, Sriram Sridhar, Pathology.
2008 Chair, Doctoral Qualifying Committee, Catalina Perdomo, G & G
2007 Doctoral Qualifying Committee, Sriram Sridhar, Pathology
2007 Doctoral Qualifying Committee, Xiaoling Zhang, Bioinformatics
2005 – 2007 Thesis Committee, Vishal Shah, Bioinformatics Program. Current
position: Management Consultant
2004 – 2007 Thesis Committee, Courtney Sil, Genetics and Genomics. Current
position: Director of Communications, Coriell Institute for Medical
Research
2005 Doctoral Qualifying Committee, Vishal Shah, Bioinformatics Program
2005 Doctoral Qualifying Committee, Panos Papageorgis, G & G
2004 Chair, Doctoral Qualifying Committee, Courtney Sil, G & G
5

Patents:
US PTO 11/918,558: Diagnostic for lung disorders using class prediction
US PTO 12/414,555: Multifactorial methods for detecting lung disorders
US PTO 60/708,446: Genetic determinant of obesity
US PTO 12/234,368: Biomarkers for smoke exposure
US PTO 61/165,668: Reversing EGFR Resistance to Treat Breast Cancer
US PTO 61/360,119: Gene Expression Markers of Oncolytic Virus Sensitivity
Publications:
1. Snyder, R.W., M.E. Lenburg, A.T. Seebaum, L.B. Grabel. 1992. Disruption of the
cytoskeleton-extracellular matrix linkage promotes the accumulation of plasminogen
activators in F9 derived parietal endoderm. Differentiation 50:153-162. PMID: 1330791.
2. Lenburg, M.E., N.R. Landau. 1993. Vpu-induced degradation of CD4: requirements for
specific amino acid residues in the cytoplasmic domain of CD4. J. Virol. 67:7238-7245.
PMID: 8230446.
3. Aiken, C., J. Konner, N. Landau, M. Lenburg, D. Trono. 1994. Nef induces CD4
endocytosis: requirement for a critical di-leucine motif in the membrane proximal CD4
cytoplasmic domain. Cell 76(5):853-64. PMID: 8124721.
4. Anderson S.J., M. Lenburg , N.R. Landau, J.V. Garcia. 1994. The cytoplasmic domain
of CD4 is sufficient for its down-regulation from the cell surface by human
immunodeficiency virus type 1 Nef. J. Virol. 68:3092-3101. PMID: 8151774.
5. Lenburg, M.E. and E.K. O’Shea. 1996. Signaling phosphate starvation. Trends
Biochem. Sci. 21:383-387. PMID: 8918192.
6. Lenburg, M.E. and E.K. O’Shea. 2001. Genetic evidence for a morphogenetic function
of the Saccharomyces cerevisiae Pho85 cyclin-dependent kinase. Genetics 157:39-51.
PMID: 11139490.
7. Lenburg, M.E., L.S. Liou, N.P. Gerry, G.M. Frampton, H.T. Cohen, M.F. Christman.
2003. Previously unidentified changes in renal cell carcinoma gene expression identified
by parametric analysis of microarray data. BMC Cancer 3:31. PMID: 14641932.
8. Carson, J.P., N. Zhiang, G. Frampton, N.P. Gerry, M.E. Lenburg and M.F. Christman.
2004. Pharmacogenomic identification of targets for adjuvant therapy with the
topoisomerase poison camptothecin. Cancer Res. 64:2096-2104. PMID: 15026349.
9. King, C., N. Guo, G.M. Frampton, N.P. Gerry, M.E. Lenburg and C.L. Rosenberg. 2004.
Reliability and reproducibility of gene expression measurements using amplified RNA
from laser microdissected primary breast tissue with oligonucleotide arrays. J. Molec.
Diagn. 7:57-64. PMID: 15681475.
6

10. Klings, E.S., S. Safaya, A.H. Adewoye, A. Odhiambo, G. Frampton, M. Lenburg, N.
Gerry, P. Sebastiani, M.H. Steinberg, and H.W. Farber. 2005. Differential Gene
Expression in Pulmonary Artery Endothelial Cells Exposed to Sickle Cell Plasma.
Physiological Genomics 21:293-298. PMID: 15741505.
11. Kanefsky, J., M. Lenburg, and C.-M. Hai. 2006. Amplitude and frequency effects of
cyclic stretch-induced inflammatory gene expression in intact airway smooth muscle.
Amer. J. Respir. Cell Mol. Biol. 34:417-425. PMID: 16339998.
12. Herbert, A., N.P. Gerry, M. McQueen, I.M. Heid, A. Pfeufer, T. Illig, H.-E. Wichmann, T.
Meitinger, D. Hunter, F.B. Hu, G. Colditz, A. Hinney, J. Hebebrand, K. Koberwitz, X. Zhu,
R. Cooper, K. Ardlie, H. Lyon, J. Hirschhorn, N.M. Laird, M.E. Lenburg, C. Lange and
M.F. Christman. 2006. A common genetic variant is associated with adult and childhood
obesity. Science 5771:279-283. PMID: 16614226.
13. Tchkonia, T, M. Lenburg, T. Thomou, N. Giorgadze, G. Frampton, T. Pirtskhalava, A.
Cartwright, M. Cartwright, J. Flanagan, I. Karagiannides, N. Gerry, R. Forse, Y.
Tchoukalova, M. Jensen, C. Pothoulakis, J. Kirkland. 2007. Identification of Depot-
Specific Human Fat Cell Progenitors through Distinct Expression Profiles and
Developmental Gene Patterns. Amer. J. Physiol. 292:298-307. PMID: 16985259.
14. Herbert, A.*, M.E. Lenburg*, D. Ulrich, N.P. Gerry, K. Schlauch, M.F. Christman. 2007.
Open access database for candidate quantitative-trait associations from a genome-wide
association study of the Framingham Heart Study. Nature Genetics 39:135-136. (* joint
first-authors). PMID: 17262019.
15. Lenburg, M.E., A. Sinha, D.V. Faller, G.V. Denis. Tumor-specific and proliferationspecific
gene expression typifies murine transgenic B cell lymphomagenesis. 2007. J.
Biol. Chem. 282:4803-4811. PMID: 17166848.
16. Spira, A., J. Beane, V. Shah, K. Steiling, G. Liu, F. Schembri, S. Gilman, Y.-M. Dumas,
P. Calner, P. Sebastiani, S. Sridhar, J. Beamis, C. Lamb, T. Anderson, N. Gerry, J.
Keane, M. Lenburg, J.S. Brody. 2007. Airway epithelial gene expression in the
diagnostic evaluation of smokers with suspect lung cancer. Nature Med. 13:361-366.
PMID: 17334370.
17. Beane, J.E., P. Sebastiani, G. Liu, J.S. Brody, M.E. Lenburg, A. Spira. 2007.
Reversible and Permanent effects of Tobacco Smoke Exposure on Airway Epithelial
Gene Expression. Genome Biology. 8: R201. PMID: 17894889.
18. Zhang, X., G. Liu, M.E. Lenburg, A. Spira. 2007. Comparison of smoking-induced gene
expression on Affymetrix exon and 3’-based expression arrays. Genome Informatics.
18:247-257. PMID: 18546492.
19. Tripathi, A., C. King, A. de la Morenas, G. Antoine, E. Hirsch, M. Kavanah, J. Mendez,
M. Stone, N. P. Gerry, M.E. Lenburg, C.L. Rosenberg. 2008. Gene expression
differences between histologically-normal breast epithelium of breast cancer cases and
controls. International Journal of Cancer. 122:1557-1566. PMID: 18058819.
7

20. Millien, G., J. Beane, M. Lenburg, P-N. Tsao, J. Lu, A. Spira, M.I. Ramirez. 2008.
Characterization of the mid-foregut transcriptome identifies genes regulated during lung
bud induction. Gene Expression Patterns. 8:124-139. PMID: 18023262.
21. Sridhar, S., F. Schembri, J. Zeskind, V. Shah, A.M. Gustafson, K. Steiling, G. Liu, Y.M.
Dumas, S. Zhang, J. Brody, M.E. Lenburg, A. Spira. 2008. Smoking-induced gene
expression changes in the bronchial airway are reflected in nasal and buccal epithelium.
BMC Genomics. 9:259. PMID: 18513428.
22. Blick, T., E. Widodo, H. Hugo, M. Waltham, M.E. Lenburg, R.M. Neve, E. Thompson.
2008. Epithelial mesenchymal transition traits in human breast cancer cell lines. Clinical
and Experimental Metastasis. 25:629-642. PMID: 18461285.
23. Beane, J.E., P. Sebastiani, T.H. Whitfield, K. Steiling, Y-M. Dumas, M.E. Lenburg, A.
Spira. 2008. A prediction model for diagnosing lung cancer that integrates genomic and
clinical features. Cancer Prevention Research. 1:56-64. PMID: 19138936.
24. Zeskind, J., M. E. Lenburg, A. Spira. 2008. Translating the COPD transcriptome:
insights into pathogenesis and tools for clinical management. Proceedings of the
American Thoracic Society. 5:834-841. PMID: 19017738.
25. Merritt, W., Y. G. Lin, L. Y. Han, A. A. Kamat, W. A. Spannuth, R. Schmandt, D.
Urbauer, L. A. Pennacchio, J-F Cheng, A. Zeidan, H. Wang, P. Mueller, M. E. Lenburg,
J. W. Gray, S. Mok, M. J. Birrer, G. Lopez-Berestein, R. L. Coleman, M. Bar-Eli, A. K.
Sood. 2008. Decreased expression of RNA interference machinery, Dicer and Drosha,
is associated with poor outcome in ovarian cancer patients. New England Journal of
Medicine. 359:2641-2650. PMID: 19092150.
26. Beane, J.E., A. Spira, M.E. Lenburg. 2009. Clinical impact of high-throughput gene
expression studies in lung cancer. Journal of Thoracic Oncology. 4:109-118. PMID:
19096318.
27. Liu, P., D.M. Slater, M. Lenburg, K. Nevis, J. Cook, C. Vaziri. 2009. Replication
licensing promotes Cyclin D1 expression and G1 progression in untransformed human
cells. Cell Cycle. 8:125-136. PMID: 19106611.
28. Schembri, F., S. Sridhar, C. Perdomo, A. Gustafson, X. Zhang, A. Ergun, J. Lu, G. Liu,
X. Zhang, J. Bowers, K. Sensinger, J.J. Collins, J. Brody, R. Getts, M.E. Lenburg, A.
Spira. 2009. MicroRNAs as modulators of smoking-induced gene-expression changes
in human airway epithelium. Proceedings of the National Academy of Sciences.
106:2319-24. PMID: 19168627.
29. Zhu, J., J.Z. Sanborn, S. Benz, F. Hsu, C. Szeto, R.M. Kuhn, D. Karolchik, J. Archie,
M.E. Lenburg, L.J. Esserman, W.J. Kent, T. Wang, D. Haussler. 2009. The UCSC
Cancer Genomics Browser. Nature Methods. 6:239-240. PMID: 19333237.
30. Steiling, K., A.Y. Kadar, A. Bergerat, J. Flanigon, S. Sridhar, V. Shah, M.E. Lenburg, Q.
R. Ahmad, M. Steffen, J.S. Brody, A. Spira. 2009. Proteomic differences in large-airway
epithelial cells collected from never and current smokers. PLoS ONE. 4(4): e5043.
PMID: 19357784.
8

31. Zhou, J., W. Huang, S. Ibaragi, Y. Ido, X. Wu, Y.O. Alekseyev, M.E. Lenburg, G. Hu, Z.
Luo. 2009. Inactivation of AMPK alters gene expression and promotes the growth of
prostate cancer cells. Oncogene. 28(18):1993-2002. PMID: 19347029.
32. Steiling, K., M.E. Lenburg, A. Spira. 2009. Airway gene expression in chronic
obstructive pulmonary disease. Proceedings of the American Thoracic Society. 6:697-
700. PMID: 20008878.
33. Papageorgis, P., A. Lambert, S. Ozturk, F. Gao, H. Pan, U. Manne, Y. Alekseyev, A.
Thiagalingam, H. Abdolmaleky, M. Lenburg, S. Thiagalingam. 2010. Smad signaling is
required to maintain epigenetic silencing during breast cancer progression. Cancer
Research. 70:968-978. PMID: 20086175.
34. Cartwright , M.J, K. Schlauch, M. E. Lenburg, T. Tchkonia, T. Pirtskhalava, A. Cartwright,
T. Thomou, J. L. Kirkland. 2010. Aging, Depot Origin, and Preadipocyte Gene
Expression. Journal of Gerontology: Biological Sciences. 65:242-251. PMID:
20106964.
35. Palomares, K.T.S., L.C. Gerstenfeld, N.A. Wigner, M.E. Lenburg, T.A. Einhorn, E.F.
Morgan. 2010. Transcriptional profiling and biochemical analysis of mechanically
induced cartilaginous tissues. Arthritis & Rheumatism. 62:1108-18. PMID: 20131271.
36. Zhang, X., G. Liu, F. Schembri, X. Zhang, Y.-M. Dumas, E.M. Langer, Y. Alekseyev,
G.T. O'Connor, D.R. Brooks, P. Sebastiani, M.E. Lenburg*, A. Spira*. 2010. Similarity
and differences in effect of cigarette smoking on gene expression in nasal and bronchial
epithelium. Physiological Genomics. 41:1-8. (* contributed equally). PMID: 19952278.
37. Gustafson, A., R. Soldi, C. Anderlind, M.B Scholand, X. Zhang, D. Walker, A.
McWilliams, G. Liu, E. Szabo, M.E. Lenburg, S. Lam, A.H. Bild, A. Spira. 2010.
Deregulation of the phosphatidylinositol 3-kinase pathway in the bronchial airway
epithelium is an early and reversible event in the development of lung cancer. Science
Translational Medicine. 2:26ra25. PMID: 20375364.
38. Hu, Z., G. Huang, A. Sadanandam, M.E. Lenburg, S Gu, N Bayani, E.A. Blakely, J.W.
Gray, J-H Mao and M. Pai. 2010. The expression level of HJURP has an independent
prognostic impact and predicts the sensitivity to radiotherapy in breast cancer. Breast
Cancer Research. 12:R18. PMID: 20211017.
39. Blick T., H. Hugo, E. Widodo, M. Waltham, S. Mani, R.A. Weinberg, R. M. Neve, M.E.
Lenburg, E.W. Thompson. 2010. Epithelial Mesenchymal Transition Traits in a Panel of
Human Breast Cancer Cell Lines Parallel the CD44 hi/ CD24 lo/- Human Breast Cancer
Stem Cell Phenotype. Journal of Mammary Gland Biology and Neoplasia. 15:235-52.
PMID: 20521089.
40. Panchenko, M.P., D.M. Dombowski, Y.O. Alekseyev, M.E. Lenburg, T.E. MacGillvray,
F.I. Preffer, J.R. Stone. 2010. Critical role of the H2O2-responsive nuclear kinase
CK1αLS in vascular cell activation. American Journal of Pathology. 177:1562-72.
PMID: 20696773.
9

41. Ooi, A.T., V. Mah, D.W. Nickerson, J.L. Gilbert, V.L. Ha, A.E Hegab, S. Hovarth, M.
Alavi, E. Maresh, D. Chia, A.C. Gower, M.E. Lenburg, A. Spira, T.C. Walser, W.D.
Wallace, S.M. Dubinett, L. Goodglick, B.N. Gomperts. 2010. A putative tumor-initiating
progenitor cell population predicts poor prognosis in smokers with non-small cell lung
cancer. Cancer Research. 70:6639-48. PMID: 20710044.
42. Boelens, M.C., A.M. Gustafson, D.S. Postma, K. Kok, G. van der Vries, P. van der Vlies,
A. Spira, M.E. Lenburg, M. Geerlings, H. Sietsma, W. Timens, A. van den Berg, H.J.M.
Groen. 2011. A chronic obstructive pulmonary disease related signature in squamous
cell lung cancer. Lung Cancer. 72:177-83. PMID: 20832896.
43. Campbell, J.D, A. Spira, M.E. Lenburg. 2011. Applying gene-expression microarrays
to pulmonary disease. Respirology. 16:407-418. PMID: 21299687.
44. Gower, A.C., K. Steiling, J.F. Brothers II, M.E. Lenburg, A. Spira. 2011. Transcriptomic
studies of the airway "field of injury" associated with smoking-related lung disease.
Proceedings of the American Thoracic Society. 8:173-179. PMID: 21543797.
45. Beane, J.E., J. Vick, F. Schembri, C. Anderlind, A.C. Gower, J. Campbell, L. Luo, X.
Zhang, J. Xiao, Y.O. Alekseyev, S. Wang, S. Levy, P.P. Massion, M.E. Lenburg, A.
Spira. Characterizing the impact of smoking and lung cancer on the airway
transcriptome using RNA-seq. Cancer Prevention Research. In Press.
Manuscripts submitted:
46. Gower, A.C., A. Spira, M.E. Lenburg. Discovering biological connections between
experimental conditions based on common patterns of differential gene expression.
Submitted.
47. Campbell. J.D., J.E. McDonough, J.E. Zeskind, D.V. Pechkovsky, C.-A. Brandsma, M.
Suzuki, J.V. Gosselink, G. Liu, Y.O. Alekseyev, J. Xiao, X. Zhang, S. Hayashi, J.D.
Cooper, W. Timens, D.S. Postma, D.A. Knight, M.E. Lenburg*, J.C. Hogg*, A. Spira*.
The gene expression signature of emphysematous lung destruction in COPD is reversed
by a potential novel therapeutic. Submitted.
48. Horiuchi, D., L. Kusdra, S. Chandriani, M.E. Lenburg, A.M. Gonzalez-Angulo, N.E.
Huskey, K.J. Creasman, S.E. Davis, G.B. Mills, L.J. Esserman, and A. Goga. Cyclindependent
kinase inhibition induces synthetic-lethality in triple-negative breast cancers
via the MYC oncogene pathway. Submitted.
49. Esserman LJ, D Berry D, A DeMichele, L Carey, M Chang, C Perou, L Van’t Veer, JW
Gray, ME Lenburg, SE Davis, M Buxton, N Hylton, C Hudis, G Broadwater, E Leung, H
Krontiras, L Montgomery, D Tripathy, C Lehman, M Liu, O Olopade, C Livasy, L
Dressler, D Chieng, J Rabban, Y Chen, A Au, C Mies, B Singh, L Tan, and the I-SPY
Investigators. Heterogeneity of Response to Chemotherapy and Recurrence-free
Survival in Neoadjuvant Breast Cancer: Results from the I-SPY TRIAL (CALGB
150007/150012; ACRIN 6657). Submitted.
50. Hu Z., J-H Mao, C. Curtis, G. Huang, W-L Kuo, M.E. Lenburg, S. Gu, J.E. Korkola, S.
Ziyad, N. Bayani, S. Samarajiwa, H.S. Feiler, N.J. Wang, M. Hardwicke, S. Laquerre,
10

J.R. Jackson, K. Wood, B. Weber, P.T. Spellman, S. Aparicio, R. Wooster, C. Caldas,
J.W. Gray. Genomic transactivation of mitotic genes predicts survival and inhibitor
response. Submitted.
51. Yang, S, M.J. O’Brien, J. Robbins, M.E. Lenburg, H. Xu, B. Burke, S. Cerda, C. Mack,
C.S. H, F.A. Farraye. Serrated and Conventional CRC Precursor Neoplasms and CpG
Island Methylation: How Individual Marker Genes and Panels Relate to Oncogene
Mutation Status and Histology. Submitted.
52. Sun-Young, L., R. Meier, P.A. Kenny, M.E. Lenburg, R. Xu, M.J. Bissell. FAM83A is coamplified
with MYC and confers resistance to EGFR inhibition. Submitted.
53. Bayani, N., M.E. Lenburg, W.-L. Kuo, N. J. Wang, Y. Guan, Z. Hu, D. Das, P. T.
Spellman, J. W. Gray, R. M. Neve. Predictive biomarkers of therapeutic sensitivity to
Pi3-kinase inhibitors in breast cancer. Submitted.
Current Research Support:
NIH/NCI R01 CA124640-01 5/1/2007 - 1/31/2012
PI: A. Spira.
$250,000/yr
Airway gene expression in smokers: an early diagnostic biomarker for lung cancer
The major goals of this project are to validate a gene-expression diagnostic biomarker for
lung cancer from histologically normal airway epithelial cells and integrate the biomarker into
predictive models that can be applied in a clinical setting; we also seek to develop a
biomarker in histologically normal airway epithelium capable of distinguishing subtypes of
lung cancer.
Role: Co-Investigator; direct gene-expression data analysis for biomarker validation and
refinement.
NIH/NIEHS U01 ES016035-01 9/1/2007 - 8/30/2011
PI: A. Spira.
$485,000/yr
A non-invasive gene-expression biomarker of airway response to tobacco exposure
The major goals of this project are to use genome-wide expression profiling of upper airway
epithelial cells obtained non-invasively to develop host response biomarkers that reflect the
degree, intensity, and extent of recovery from tobacco-smoke exposure. We will also
develop biomarkers that assess the perturbation of physiologic pathways in response to
tobacco. These genomic biomarkers will be correlated with lung function and systemic
markers of oxidant stress and inflammation.
Role: Co-Investigator; direct gene-expression data analysis and biomarker discovery, testing
and validation.
NIH/NCRR UL1 RR025771 5/19/2008 - 4/30/2013
PI: D. Center.
$4,600,000/yr
Boston University Clinical and Translational Science Award Program
The new NIH Clinical and Translational Science Award will create an academic home for
11

clinical and translational research and training. It will fund a hospital and University wide
institute that will add multiple other programs to the portfolio of resources available for
clinical researchers, including community outreach, research ethics, and bioinformatics to
further facilitate translation of basic science discoveries into improvements in the diagnosis
and treatment of human diseases.
Role: Deputy Director, Translational Bioinformatics Core; develop and lead a bioinformatics
consultation service to support translational researchers at Boston University.
NIH/NHLBI N01 HC25195 4/1/2008 – 3/31/2012
PI: Wolf
$7,745,538/yr
The Framingham Heart Study
One aspect of the long-running Framingham Heart Study (FHS) involves finding genetic
determinants of common medically important traits, and considerable recent effort has been
directed to finding SNP variants associated with these traits through Genome-Wide
Association Studies (GWAS). The informatic challenges presented by these studies are
formidable, but overlap considerably with the informatic challenges inherent in our Genome-
Wide Gene Expression Studies of lung disease. We are therefore collaborating with the
FHS investigators to build bioinformatic tools to store, manage, and integrate the results of
these studies; leveraging our expertise in this area.
Role: Co-Investigator, bioinformatics.
NIH/NHLBI R01 HL095388-01 10/1/2008 - 9/30/2012
PI: M.E. Lenburg.
$500,000/yr
Linking airway genomics to the pathogenesis and clinical heterogeneity of COPD
The major goals of this project are to apply whole-genome exon-level and microRNA
expression platforms and a variety of novel computational methodologies to identify
molecular subtypes of COPD that may contribute to the extreme clinical diversity of this
disease. We will also work to understand how these profiles change during disease
progression, and uncover genetic polymorphisms that influence both molecular and clinical
COPD-related traits. The hope is that this work will provide insights into the molecular
pathogenesis of COPD and specific COPD-related traits, including degree of airflow
obstruction, emphysema, small airways disease, and the rate of disease progression.
Role: PI.
NIH/NHLBI RC2 HL101715 9/30/2009 – 8/31/2011
PI: D. Schwartz
$5,385,643/yr
Lung Genomics Research Consortium
The major goals of this project are to generate a high resolution genetic, molecular, and
quantitative phenotype warehouse for the lung tissue specimens collected as part of the
NHLBI Lung Tissue Research Consortium.
Role: Co-Investigator; direct analysis of high-throughput transcriptome sequencing data.
12

DOD/LCRP CTRA LC090615 7/1/10 – 6/30/14
PI: A. Spira
$200,000/yr
Molecular Profiles for Lung Cancer Pathogenesis and Detection in US Veterans
The overall hypothesis of this proposal is that smoking-induced chronic injury, inflammation,
and dysregulated epithelial repair result in a field of injury that supports lung carcinogenesis
and that the associated molecular, biochemical and cellular events will inform the networks
and pathways involved in lung carcinogenesis. We anticipate that this research will lead to
the discovery of biomarkers for early lung cancer detection and development of novel
therapeutic targets. These studies will be performed predominantly in veterans and will
provide novel screening methods and therapies for veterans, which will be applicable to the
broader population.
Role: Co-Investigator; direct analysis of high-throughput transcriptome sequencing data.
NIH/NCI U01 CA152751-01 7/1/2010 – 6/30/2015
PI: M.E. Lenburg
$600,000/yr
The UCLA – Boston University Lung Cancer Biomarker Development Laboratory
The UCLA-Boston University Lung Cancer Biomarker Development Laboratory (UCLA-BU
BDL) is a multidisciplinary, translational research program designed to develop and
characterize new biomarkers and assays through translational research in the molecular
pathogenesis of lung cancer.
Role: PI.
Pending Research Support:
DOD/LCRP CTRA 7/1/2011 – 6/30/2016
PI: A. Spira. Site PI: M.E. Lenburg (Genomics Core)
Detection of Early Lung Cancer Among Military Personnel (DECAMP)
A challenge inherent in the use of repeat imaging for lung cancer screening is that small
indeterminate nodules are found frequently, of which those that are related to a malignant
process represent only a small fraction. The goal of this project is to develop more
eeffective tools to more precisely identify individuals that will benefit from screening and to
rapidly differentiate the large number of benign radiographic abnormalities from those that
represent lung cancer following their initial detection.
Role: Core PI.
NIH/NHLBI R01 HL107884-01 4/1/2011 – 3/31/2015
PI: M.E. Lenburg
Molecular biomarkers of airway and lung linking COPD and Lung Cancer
This project will test the hypothesis that genomic alterations in the airway and lung tissue of
smokers reflects COPD-specific patterns of lung carcinogenesis. Understanding the
molecular connections between COPD and lung cancer will allow us to develop improved
biomarkers for lung cancer surveillance among smokers with COPD and develop targeted
lung-cancer chemoprevention strategies that interfere with lung-cancer promoting aspects of
COPD pathogenesis.
13

Role: PI.
NIH/NIEHS R01 RFA-ES-10-008 7/1/2011 – 6/30/2013
PI: M.E. Lenburg
Validation of a Genomic Biomarker of Response to Environmental Tobacco Smoke
This project seeks to validate novel biomarkers for assessing the body’s response to
second-hand tobacco smoke (SHS). By measuring the response to exposure, rather than
the exposure itself, these tools will allow insights into how individuals respond differently to
SHS exposure, the relationship between this response and the risk of disease, and provide
a unique tool for evaluating the effects of SHS exposure minimization efforts on the
physiologic burden that results from exposure to this deadly environmental pollutant.
Role: PI.
Completed Research Support:
NIH/NIGMS R01 GM82962-01A2 4/01/2009 – 6/30/2010
PI: D. Remick
$207,500/yr
Role of Cytokines in Sepsis and Trauma
This grant studies the inflammatory response in sepsis, using the cecal ligation and
puncture model in mice.
Role: Co-Investigator, direct proteomic analysis.
Invited Presentations:
October 16, 2003
October 30, 2003
Straightforward approaches to getting useful information
from a whole mess of data. BUSM Genetics & Genomics
Seminar Series.
Analysis and informatics for microarray experiments. BUSM
Genetics & Genomics Annual Retreat.
December 5, 2003 Some new microarray data analysis tricks. BUSM Genetics &
Genomics Seminar Series.
January 26, 2004
March 9, 2004
March 23, 2004
Developing a data analysis workflow. BUSM Genetics &
Genomics Seminar Series.
Microarray data analysis. Affymetrix, Inc. Santa Clara, CA
Clinical research applications of microarray technology.
BUSM Ob/Gyn Grand Rounds.
14

April 26, 2004
May 7, 2004
May 10, 2004
May 20, 2004
July 14, 2004
August 30, 2004
September 30, 2004
October 19, 2004
October 22, 2004
November 1, 2004
November 11, 2004
November 4, 2004
May 6, 2005
September 1, 2005
October 20, 2005
April 20, 2006
April 9, 2007
April 19, 2007
Practical microarray data analysis. BU Biomedical
Engineering.
The promise of genome-wide experimentation. BUSM Board
of Visitors Presentation.
Preadipocytes from different human fat depots: distinct cell
types? Affymetrix User Meeting. New York, NY.
From hybridization to insight. IBM Corporation.
From hybridization to insight. Iobion, Inc.
FHS Dense SNP Map Project: informatics and computational
support. Pfizer, Inc. New London, CT.
FHS Dense SNP Map Project. Affymetrix, Inc. Santa Clara, CA.
Computational analysis of genotyping data. BU Bioinformatics
Program Student Seminar Series.
Microarray-based phenotype fingerprinting. BUSM Genetics &
Genomics Seminar Series.
Computational analysis of genotyping data. BU Bioinformatics
Seminar Series.
Computational analysis of genotyping data. Novartis, Inc.
Cambridge, MA
Another 2000 arrays. BUSM G & G Annual Retreat.
The promise of genome-wide experimentation. BUSM Board
of Visitors Presentation.
Following up obesity-predisposing associations. Pfizer, Inc.
New London, CT.
Tools for managing and analyzing genome-wide association
data. BUSM Genetics & Genomics Annual Retreat.
Tools for managing and analyzing genome-wide association
data. Affymetrix Microarray Bulletin Webinar Series. International
Webinar.
Bioinformatic challenges of genome-wide association
studies. The Coriell Institute. Camden, NJ.
Microarrays in translational research. Lawrence Berkeley
National Laboratory. Berkeley, CA.
15

August 27, 2007
January 24, 2008
February 1, 2008
July 11, 2008
November 8, 2008
January 14, 2009
January 14, 2009
January 30, 2009
February 11, 2009
April 17, 2009
May 7, 2009
August 3, 2009
October 1, 2009
Development of a diagnostic gene-expression biomarker for
lung cancer. Bioinformatics Program, Department of
Biostatistics, University of California at San Francisco. San
Francisco, CA.
Non-invasive gene expression biomarkers of airway response
to tobacco exposure. Genes and the Environment Initiative
Annual Meeting, Bethesda, MD.
Methods for using public gene-expression data to explore
cancer biology. Breast Oncology Program Annual Meeting,
University of California at San Francisco. San Francisco, CA.
Airway epithelial gene expression as a biomarker for host
responses to tobacco smoke. New Directions in Exposure
Assessment. UCLA. Los Angeles, CA.
Airway epithelial gene expression in the diagnostic
evaluation of smokers with suspect lung cancer. NCI
Translates. Washington, DC.
Non-invasive gene expression biomarkers of airway response
to tobacco exposure. Genes and the Environment Initiative
Annual Meeting, Bethesda, MD.
Non-invasive miRNA biomarkers of airway response to
tobacco exposure. Genes and the Environment Initiative Annual
Meeting, Bethesda, MD.
Airway epithelial gene expression in the diagnostic
evaluation of smokers with suspect lung cancer. British
Thoracic Oncology Group Annual Meeting, Dublin, Ireland.
Gene expression assessment of the physiological response
to tobacco-smoke exposure and tobacco-related lung
disease. Pathology and Laboratory Medicine Grand Rounds.
Boston University School of Medicine.
Detecting dynamic gene expression. Lawrence Berkeley
National Laboratory. Berkeley, CA.
Airway epithelial gene expression in the diagnostic
evaluation of smokers with suspect lung cancer. Novel Tools
for Risk Assessment and Early Detection of Premalignant Lesions
and Cancer. German Cancer Aid. Bonn, Germany.
Non-invasive gene expression biomarkers of airway response
to tobacco exposure. Genes and the Environment Meeting.
NIEHS. Raleigh, NC.
Basal and Luminal Properties of Breast Cancer Cell Lines.
16

Lawrence Berkeley National Laboratory.
October 20, 2009
November 3, 2009
January 26, 2010
February 25, 2010
April 30, 2010
September 14, 2010
November 2, 2010
May 9, 2011
Whole transcriptome profiling approaches for understanding
the physiologic responses to tobacco-smoke exposure.
International Society for the Study of Xenobiotics Annual Meeting.
Baltimore, MD.
From gene lists to biological insights. Framingham Heart
Study Investigator’s Meeting. Framingham, MA
Non-invasive gene expression biomarkers of airway response
to tobacco exposure. Genes and the Environment Initiative
Annual Meeting. NIH, Bethesda, MD.
Genome-wide gene expression profiling of physiologic and
pathogenic responses to tobacco smoke. PMI Research
Colloquium. Neuchatel, Switzerland.
Molecular Heterogeneity of Chronic Obstructive Pulmonary
Disease. Lawrence Berkeley National Laboratory. Berkeley, CA.
An airway epithelial gene expression biomarker for
evaluation of smokers with suspect lung cancer. NCI EDRN
FDA Education Workshop. NIH. Bethesda, MD.
Recurrent patterns of breast-cancer related gene expression.
Lawrence Berkeley National Laboratory.
Genome-wide approaches to understanding the role of
miRNAs in smoking-related lung disease. University of
Giessen and Marburg Lung Center Symposium: “Micromanaging
the lung”. Braunfels, Germany.
17

Don D. Sin, MD
Don Sin is a Professor of Medicine at the University of British Columbia (UBC), a
Canada Research Chair in chronic obstructive pulmonary disease (COPD), and a senior
scholar with the Michael Smith Foundation for Health Research. He is also the site head
of Respiratory Medicine at St. Paul’s Hospital in Vancouver. He is a current member of
the international Global initiative for chronic Obstructive Lung Disease (GOLD)
scientific committee and has authored more than 200 peer-review articles. His main
research focus is to discover novel biomarkers to improve the care and diagnosis of
patients with COPD and to better understand how lung inflammation leads to
cardiovascular diseases and lung cancer in men and women.

Name: 林 恕 民
台 北 醫 學 大 學 83 年 06 月 畢 業
經 歷
1. 1999 to present, 長 庚 醫 院 胸 腔 科 主 治 醫 師
2. 2000 to 2002, Senior fellow, Division of Pulmonary and Critical Care Medicine,
University of Washington, Seattle, WA, USA
現 任 :
1. 長 庚 醫 院 胸 腔 科 檢 查 室 主 任
2. 長 庚 醫 院 內 科 第 三 加 護 病 房 主 任
3. 長 庚 大 學 醫 學 系 助 理 教 授
4. 衛 生 署 疾 病 管 制 局 諮 詢 委 員
教 學 目 標 與 綱 要
1. 認 識 氣 喘 的 病 因 、 症 狀 以 及 預 防 方 法
2. 氣 喘 治 療 的 最 新 發 展
3. 認 識 COPD 的 病 因 、 症 狀 以 及 預 防 方 法
4. COPD 治 療 的 最 新 發 展
5. 氣 喘 與 COPD 在 病 因 、 症 狀 與 治 療 的 差 異

Name: 郭 壽 雄
臺 灣 大 學 醫 學 院 醫 學 系
經 歷
臺 大 醫 院 內 科 住 院 總 醫 師
臺 大 醫 院 內 科 部 及 檢 驗 醫 學 部 主 治 醫 師
臺 大 醫 學 院 內 科 及 檢 驗 醫 學 科 教 授
台 大 醫 院 檢 驗 醫 學 部 細 胞 及 一 般 檢 驗 科 主 任
現 任
亞 東 醫 院 胸 腔 內 科 主 治 醫 師
臺 大 醫 學 院 內 科 及 檢 驗 醫 學 科 兼 任 教 授
臺 大 醫 院 內 科 兼 任 主 治 醫 師
臺 灣 醫 學 會 理 事
台 灣 胸 腔 暨 重 病 加 護 醫 學 會 理 事
台 灣 肺 癌 醫 學 會 理 事
國 際 細 胞 學 會 研 究 員 (FIAC)
美 國 胸 腔 醫 師 學 院 院 士 (FCCP)
全 球 氣 喘 策 略 組 織 (GINA) 大 會 委 員

Name: 江 伯 倫
台 大 醫 學 系 ( 民 國 七 十 二 年 )
美 國 加 州 大 學 戴 維 斯 分 校 免 疫 學 博 士 ( 民 國 八 十 年 )
台 大 醫 院 小 兒 科 住 院 醫 師
美 國 加 州 大 學 戴 維 斯 分 校 博 士 後 研 究
台 大 醫 學 院 臨 床 醫 學 研 究 所 博 士 後 研 究
台 大 醫 學 院 臨 床 醫 學 研 究 所 副 教 授
現 任
台 大 醫 學 院 小 兒 科 及 臨 床 醫 學 研 究 所 教 授
台 大 醫 院 小 兒 部 過 敏 免 疫 風 溼 科 主 治 醫 師 兼 主 任
台 大 醫 學 院 動 物 研 究 中 心 主 任
台 大 醫 院 醫 學 研 究 部 訓 練 規 劃 組 組 長
兒 童 過 敏 及 氣 喘 文 教 學 術 基 金 會 執 行 長
專 長
小 兒 過 敏 疾 病
小 兒 風 溼 疾 病
免 疫 不 全 疾 病
臨 床 免 疫 學
分 子 及 細 胞 免 疫 學
免 疫 療 法
基 因 療 法

Name: 郭 漢 彬
私 立 台 北 醫 學 院 醫 學 系 畢 業
英 國 倫 敦 大 學 帝 國 學 院 臨 床 藥 理 學 博 士
經 歷
長 庚 醫 院 胸 腔 內 科 研 究 員
長 庚 醫 院 胸 腔 內 科 助 理 教 授
長 庚 大 學 醫 學 系 副 教 授 -
現 任
長 庚 紀 念 醫 院 林 口 院 區 胸 腔 內 科 主 治 醫 師
長 庚 紀 念 醫 院 胸 腔 內 科 系 主 任
長 庚 大 學 醫 學 系 教 授

Curriculum Vitae (as from 6 June 2011)
Professor Richard Li‐Cher LOH
MBBCh, BAO (Irel), MD (London), FRCP (Edin), FCCP (USA), FAMM (Mal)
Professor Richard Loh is currently Professor of Medicine and Head, Department of Medicine in
Penang Medical College, Malaysia, and Adjunct Professor, Postgraduate Studies and Research,
International Medical University, Malaysia. He earned his medical degree from the Royal College
of Surgeons in Ireland before pursuing his higher specialist training in Respiratory Medicine in
London. During this time, he also completed his Doctor of Medicine degree from University of
London on research into asthma immunology and novel immunomodulatory approaches. His
current research focuses on various hospital‐based TB and non‐TB respiratory infections, as well
as the under‐explored aspects of local asthma and COPD management such as influence of
ethnicity, breathlessness perception and self‐management strategies.
Professor Loh is a widely published investigator who lectures regularly in both national and
international meetings, as well as an actively practicing chest physician. He was the founding
Editor of International e‐Journal of Science, Medicine and Education of International Medical
University, and is an editorial board member of several medical journals including Respirology.
He has held various positions in national professional bodies including The Malaysian Thoracic
Society and College of Physician, Academy of Medicine Malaysia, and is the immediate past
assembly head for the “Non‐Tuberculosis” Infectious Disease group of the Asia Pacific Society of
Respirology. He is a Fellow of the Royal College of Physician of Edinburgh, the American College
of Chest Physician, and Academy of Medicine Malaysia.

姓 名 : 許 正 園 (Hsu, Jeng-Yuan)
性 別 : 男
出 生 日 期 :1957.3.12
學 經 歷 資 料
學 歷 :
1. 私 立 中 國 醫 藥 學 院 醫 學 系 17 屆 畢 業 (1974 年 10 月 至 1981 年 6 月 )
2. 英 國 倫 敦 國 立 心 肺 研 究 院 胸 腔 部 進 修 哮 喘 與 慢 性 咳 嗽 (1992 年 1 月 至
1993 年 1 月 )
現 任 : 台 中 榮 民 總 醫 院 胸 腔 內 科 主 任
台 中 榮 民 總 醫 院 醫 學 倫 理 與 法 律 中 心 主 任
經 歷 : 台 中 榮 民 總 醫 院 內 科 部 住 院 醫 師 (1983 年 6 月 至 1987 年 6 月 )
台 中 榮 民 總 醫 院 內 科 部 住 院 總 醫 師 (1987 年 7 月 至 1988 年 6 月 )
台 中 榮 民 總 醫 院 胸 腔 內 科 主 治 醫 師 (1988 年 7 月 至 2004 年 1 月 )
台 中 榮 民 總 醫 院 胸 腔 內 科 主 任 (2004 年 1 月 至 今 )
醫 學 會 員 或 專 科 : 台 灣 胸 腔 暨 重 症 加 護 醫 學 會 理 事
台 灣 氣 喘 諮 詢 協 會 理 事
台 中 市 胸 腔 疾 病 關 懷 協 會 理 事
台 灣 內 科 醫 學 會 專 科 醫 師
台 灣 胸 腔 暨 重 症 加 護 醫 學 會 專 科 醫 師
美 國 國 際 胸 腔 學 會 會 員
專 長 : 呼 吸 道 疾 病 診 斷 與 治 療 , 包 括 氣 喘 、 慢 性 阻 塞 性 肺 疾 等
1

Name: 黃 明 賢
高 雄 醫 學 大 學 醫 學 院 醫 學 系
日 本 東 京 醫 科 大 學 大 學 院 博 士
經 歷
日 本 東 京 醫 科 大 學 研 究 醫 生
美 國 Mayo Clinic 研 究 員
美 國 阿 肯 色 州 立 大 學 研 究 員
高 雄 醫 學 大 學 附 設 醫 院 肺 功 能 室 主 任
衛 生 署 疾 病 管 制 局 結 核 病 診 療 醫 師
國 家 衛 生 研 究 院 肺 癌 研 究 委 員 會 委 員
高 雄 醫 學 大 學 醫 學 社 會 學 與 社 會 工 作 學 系 主 任
高 雄 醫 學 大 學 呼 吸 照 護 學 系 主 任
高 雄 醫 學 大 學 附 設 醫 院 胸 腔 內 科 主 任
高 雄 醫 學 大 學 附 設 醫 院 內 科 部 主 任
高 雄 醫 學 大 學 附 設 醫 院 副 院 長
台 灣 臨 床 細 胞 學 會 理 事 長
現 任
胸 腔 內 科 主 治 醫 師
高 雄 醫 學 大 學 醫 學 系 內 科 學 教 授
美 國 國 際 胸 腔 學 院 院 士
專 科 執 照 與 學 會
中 華 民 國 肺 癌 學 會 理 事
中 華 民 國 臨 床 腫 瘤 醫 學 會 理 事
台 灣 胸 腔 暨 重 症 加 護 醫 學 會 專 科 醫 師 、 理 事
中 華 民 國 重 症 專 科 醫 師
中 華 民 國 胸 腔 病 學 會 專 科 醫 師
中 華 民 國 內 科 專 科 醫 師
中 華 民 國 結 核 病 專 科 醫 師
中 華 民 國 細 胞 病 理 專 科 醫 師

Name: 李 岡 遠
倫 敦 大 學 國 立 心 肺 研 究 所 博 士
台 北 醫 學 大 學 醫 學 系 畢 業
經 歷
加 拿 大 多 倫 多 大 學 研 究 員
長 庚 醫 院 研 究 員 -
現 任
長 庚 紀 念 醫 院 林 口 院 區 胸 腔 內 科 主 治 醫 師
長 庚 紀 念 醫 院 胸 腔 內 科 助 理 教 授

CURRICULUM VITAE
NAME, Family name:
Forename:
Koarai
Akira
Present address (Mailing address):
Third Department of Internal Medicine, Wakayama Medical University School of
Medicine, Wakayama, Japan
811-1 Kimiidera
Wakayama 641-8509
Japan
TEL: +81 (0)73 441 0618 (including country code)
FAX: +81 (0)73 446 2877
E-mail: koarai@wakayama-med.ac.jp
Personal:
Sex:
Male
DATE OF BIRTH: 25th July 1969
PLACE OF BIRTH: Fukushima prefecture
NATIONARITY: Japanese
Marital Status: Married, with two children.
EDUCATION:
1989-1995:
Tohoku University School of Medicine. Awarded the degree of Medical Doctor
(license number: 370896).
1997-2001:
Postgraduate student at the First Department of Internal Medicine, Tohoku
University School of Medicine, working with Dr. Ichinose on the airway
inflammation, asthma and COPD (supervised by Professor K. Shirato). Awarded
the degree of Doctor of Philosophy.
Work Experience:
1995-1997:
Clinical training of internal medicine, Yamagata City Hospital.
2001-2002:
Clinical training of respiratory medicine, Sendai National Hospital.
2002-2004:
Research fellow at the Division of Respiratory & Infectious Diseases, Tohoku
University Graduate School of Medicine, working with Dr. Ichinose on the airway
inflammation, asthma and COPD (supervised by Professor T. Hattori).

2004–2006:
Visiting Academic Researcher, Airways Disease Section, National Heart and
Lung Institute, Imperial College London (Supervised by Professor Peter J
Barnes)
2006–2007:
Medical Doctor, Respiratory medicine, Wakayama National Hospital
2007-present:
Assistant Professor, Third Department of Internal Medicine, Wakayama Medical
University School of Medicine, working with Professor Ichinose on the airway
inflammation, asthma and COPD.
MEDICAL licensure: 370896
Membership of academic societies:
American Thoracic Society
European Respiratory Society
Japanese Society of Internal Medicine
Japanese Respiratory Society
Japanese Society of Allergology
The Japan Society for Respiratory Endoscopy
Awards:
Grant for foreign Study from Japanese Respiratory Foundation Pfizer Fellowship
in 2004
Grant for foreign Study from Kanae Foundation for the promotion of medical
science in 2004
Travel award to attend the 6th International Conference on the Biology,
Chemistry, and Therapeutic Applications of Nitric Oxide in 2010
Publications:
See attached list.

Publications:
1. Koarai A, Traves SL, Fenwick PS, Brown SM, Chana KK, Russell RE, Nicholson AG,
Barnes PJ, Donnelly LE. Expression of Muscarinic Receptors by Human Macrophages.
The European respiratory journal : official journal of the European Society for Clinical
Respiratory Physiology 2011(accepted).
2. Matsunaga K, Hirano T, Akamatsu K, Koarai A, Sugiura H, Minakata Y, Ichinose M.
Exhaled nitric oxide cutoff values for asthma diagnosis according to rhinitis and
smoking status in Japanese subjects. Allergology international : official journal of the
Japanese Society of Allergology 2011;60:331-337.
3. Furukawa K, Sugiura H, Matsunaga K, Ichikawa T, Koarai A, Hirano T, Yanagisawa S,
Minakata Y, Akamatsu K, Kanda M, Nishigai M, Ichinose M. Increase of nitrosative
stress in patients with eosinophilic pneumonia. Respiratory research 2011;12:81.
4. Akamatsu K, Matsunaga K, Sugiura H, Koarai A, Hirano T, Minakata Y, Ichinose M.
Improvement of Airflow Limitation by Fluticasone Propionate/Salmeterol in Chronic
Obstructive Pulmonary Disease: What is the Specific Marker? Frontiers in
pharmacology 2011;2:36.
5. Minakata Y, Ueda H, Akamatsu K, Kanda M, Yanagisawa S, Ichikawa T, Koarai A,
Hirano T, Sugiura H, Matsunaga K, Ichinose M. High COPD prevalence in patients with
liver disease. Internal medicine 2010;49:2687-2691.
6. Koarai A, Sugiura H, Yanagisawa S, Ichikawa T, Minakata Y, Matsunaga K, Hirano T,
Akamatsu K, Ichinose M. Oxidative stress enhances toll-like receptor 3 response to
double-stranded RNA in airway epithelial cells. American journal of respiratory cell and
molecular biology 2010;42:651-660.
7. Yanagisawa S, Sugiura H, Yokoyama T, Yamagata T, Ichikawa T, Akamatsu K, Koarai
A, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M. The possible role of
hematopoietic cell kinase in the pathophysiology of COPD. Chest 2009;135:94-101.
8. Yanagisawa S, Koarai A, Sugiura H, Ichikawa T, Kanda M, Tanaka R, Akamatsu K,
Hirano T, Matsunaga K, Minakata Y, Ichinose M. Oxidative stress augments toll-like
receptor 8 mediated neutrophilic responses in healthy subjects. Respiratory research
2009;10:50.
9. Sugiura H, Ichikawa T, Koarai A, Yanagisawa S, Minakata Y, Matsunaga K, Hirano T,
Akamatsu K, Ichinose M. Activation of Toll-like receptor 3 augments myofibroblast

differentiation. American journal of respiratory cell and molecular biology 2009;40:654-
662.
10. Matsunaga K, Yanagisawa S, Ichikawa T, Akamatsu K, Koarai A, Hirano T, Sugiura H,
Minakata Y, Ichinose M. Molecular mechanism of the additive effects of leukotriene
modifier in asthmatic patients receiving steroid therapy. Allergology international :
official journal of the Japanese Society of Allergology 2009;58:89-96.
11. Matsunaga K, Ichikawa T, Yanagisawa S, Akamatsu K, Koarai A, Hirano T, Sugiura H,
Minakata Y, Ichinose M. Clinical Application of Exhaled Breath Condensate Analysis in
Asthma: Prediction of FEV(1) Improvement by Steroid Therapy. Respiration;
international review of thoracic diseases 2009;78:393-398.
12. Sugiura H, Komaki Y, Koarai A, Ichinose M. Nitrative stress in refractory asthma. The
Journal of allergy and clinical immunology 2008;121:355-360.
13. Minakata Y, Sugiura H, Yamagata T, Yanagisawa S, Ichikawa T, Koarai A, Akamatsu
K, Hirano T, Matsunaga K, Ichinose M. Prevalence of COPD in primary care clinics:
correlation with non-respiratory diseases. Internal medicine 2008;47:77-82.
14. Matsunaga K, Kanda M, Hayata A, Yanagisawa S, Ichikawa T, Akamatsu K, Koarai A,
Hirano T, Sugiura H, Minakata Y, Ichinose M. Peak expiratory flow variability adjusted
by forced expiratory volume in one second is a good index for airway responsiveness
in asthmatics. Internal medicine 2008;47:1107-1112.
15. Ichikawa T, Sugiura H, Koarai A, Yanagisawa S, Kanda M, Hayata A, Furukawa K,
Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M.
Peroxynitrite augments fibroblast-mediated tissue remodeling via myofibroblast
differentiation. American journal of physiology Lung cellular and molecular physiology
2008;295:L800-808.
16. Tomaki M, Sugiura H, Koarai A, Komaki Y, Akita T, Matsumoto T, Nakanishi A, Ogawa
H, Hattori T, Ichinose M. Decreased expression of antioxidant enzymes and increased
expression of chemokines in COPD lung. Pulmonary pharmacology & therapeutics
2007;20:596-605.
17. Komaki Y, Sugiura H, Koarai A, Tomaki M, Ogawa H, Akita T, Hattori T, Ichinose M.
Cytokine-mediated xanthine oxidase upregulation in chronic obstructive pulmonary
disease's airways. Pulmonary pharmacology & therapeutics 2005;18:297-302.
18. Sugiura H, Ichinose M, Tomaki M, Ogawa H, Koarai A, Kitamuro T, Komaki Y, Akita T,
Nishino H, Okamoto S, Akaike T, Hattori T. Quantitative assessment of protein-bound

tyrosine nitration in airway secretions from patients with inflammatory airway disease.
Free radical research 2004;38:49-57.
19. Sugiura H, Ichinose M, Yamagata S, Koarai A, Shirato K, Hattori T. Correlation
between change in pulmonary function and suppression of reactive nitrogen species
production following steroid treatment in COPD. Thorax 2003;58:299-305.
20. Koarai A, Ichinose M, Ishigaki-Suzuki S, Yamagata S, Sugiura H, Sakurai E, Makabe-
Kobayashi Y, Kuramasu A, Watanabe T, Shirato K, Hattori T, Ohtsu H. Disruption of L-
histidine decarboxylase reduces airway eosinophilia but not hyperresponsiveness.
American journal of respiratory and critical care medicine 2003;167:758-763.
21. Ichinose M, Sugiura H, Yamagata S, Koarai A, Tomaki M, Ogawa H, Komaki Y, Barnes
PJ, Shirato K, Hattori T. Xanthine oxidase inhibition reduces reactive nitrogen species
production in COPD airways. The European respiratory journal : official journal of the
European Society for Clinical Respiratory Physiology 2003;22:457-461.
22. Koarai A, Ichinose M, Sugiura H, Tomaki M, Watanabe M, Yamagata S, Komaki Y,
Shirato K, Hattori T. iNOS depletion completely diminishes reactive nitrogen-species
formation after an allergic response. The European respiratory journal : official journal
of the European Society for Clinical Respiratory Physiology 2002;20:609-616.
23. Yamagata S, Ichinose M, Sugiura H, Koarai A, Koike K, Shirato K. Effect of a calcium
sensitization modulator, Y-27632, on isolated human bronchus and pulmonary artery.
Pulmonary pharmacology & therapeutics 2000;13:25-29.
24. Koarai A, Ichinose M, Sugiura H, Yamagata S, Hattori T, Shirato K. Allergic airway
hyperresponsiveness and eosinophil infiltration is reduced by a selective iNOS
inhibitor, 1400W, in mice. Pulmonary pharmacology & therapeutics 2000;13:267-275.
25. Ichinose M, Sugiura H, Yamagata S, Koarai A, Shirato K. Increase in reactive nitrogen
species production in chronic obstructive pulmonary disease airways. American journal
of respiratory and critical care medicine 2000;162:701-706.
26. Sugiura H, Ichinose M, Oyake T, Mashito Y, Ohuchi Y, Endoh N, Miura M, Yamagata
S, Koarai A, Akaike T, Maeda H, Shirato K. Role of peroxynitrite in airway
microvascular hyperpermeability during late allergic phase in guinea pigs. American
journal of respiratory and critical care medicine 1999;160:663-671.

Name: 余 忠 仁
• 國 立 台 灣 大 學 醫 學 系 畢
• 國 立 台 灣 大 學 臨 床 醫 學 研 究 所 博 士
經 歷
• 台 灣 大 學 醫 學 院 附 設 醫 院 實 習 醫 師 1986-1987
• 台 灣 大 學 醫 學 院 附 設 醫 院 內 科 住 院 醫 師 1987-1990
• 台 灣 大 學 醫 學 院 附 設 醫 院 內 科 部 胸 腔 內 科 受 訓 醫 師 1990-1992
• 台 灣 大 學 醫 學 院 附 設 醫 院 內 科 部 胸 腔 內 科 主 治 醫 師 1992-Now
• 台 灣 大 學 醫 學 院 內 科 助 理 教 授 1997-2004
• 美 國 加 州 大 學 戴 維 斯 分 校 研 究 1998/9-1999/3
• 台 灣 大 學 醫 學 院 內 科 副 教 授 2004-
現 任
• 台 大 醫 學 院 內 科 教 授
• 台 大 醫 院 內 科 部 主 治 醫 師
• 台 大 醫 院 內 科 部 副 主 任
工 作 重 點
目 前 擔 任 護 理 系 、 藥 學 系 、 醫 學 系 內 科 學 課 程 講 師 。 並 參 與 多 項 國 際 性 之 臨 床 試
驗 計 畫 。 目 前 主 要 的 研 究 方 向 為 肺 癌 之 基 因 分 子 生 物 學 研 究 。 主 要 包 括 肺 癌 之 黏
液 素 基 因 之 調 控 與 表 現 , 並 因 此 獲 得 國 科 會 研 究 獎 助 及 院 內 研 究 論 文 傑 出 獎 。 其
他 研 究 範 疇 包 括 肺 癌 之 微 衛 星 體 變 異 及 其 他 基 因 變 異 , 與 慢 性 阻 塞 性 肺 病 之 病 因
學 研 究 。

CURRICULUM VITAE
Date: April. 07, 2008
NAME
林 鴻 銓 (Lin, Horng-Chyuan)
SEX
Male
BIRTH DATE April 24, 1964.
BIRTH PLACE
Hsin-Chu Taiwan, R.O.C.
CITIZENSHIP
Republic of China
HOME ADDRESS & TEL. No. No.406-01, residential community of Chang Gung
Memorial Hospital, Kwei-San, Tao-Yan Taiwan, R.O.C.
TEL: 03-3286769
E-mail: lin53424@ms13.hinet.net
OFFICE ADDRESS & TEL. No. Lin-Kou Medical Center of Chang Gung Memorial Hospital,
Kwei-San, Tao-Yan Taiwan, R.O.C.
Office: 03-3281200 -extension 8467 or 8468
Fax: 03-3272474
CHINESE PERMANENT J120303636
REGISTRATION No.
LANGUAGE
Mother language: Taiwanese
Mastered language: Chinese, English
SPOUSE 符 原 君 (Fu, Yuan-Chun ), Jan 18, 1964
CHILDREN 林 宇 垚 , Sep 13, 1994. Male
林 宇 軒 , Mar 18, 1996. Male
林 宇 暉 , Jan 20, 1998. Male
EDUCATION 1. September 1982 - June 1989
Medical Department, Kaoshung Medical College,
Taipei Taiwan, R.O.C.
2. August 1987 - May 1989
Internship in National Taiwan University Hospital
CHRONOLOGY OF EMPLOYMENT
1. July 1989 - June 1992
Residency in Department of Internal Medicine, Lin-Kou
Medical Center of Chang Gung Memorial Hospital
2. Since July 1992
Fellowship in Department of Thoracic Medicine, Lin-Kou
Medical Center of Chang Gung Memorial Hospital
3. Since July 1994
Attending physician (V.S.) in Department of
ThoracicMedicine, Lin-Kou Medical Center of Chang Gung
Memorial Hospital.
4. Since July 1997
Assist Professor in Department of Thoracic Medicine, Lin-
Kou Medical Center of Chang Gung Memorial Hospital
5. Since July 2000
Assist Professor of Chang Gung University
6. Since July 2001
Assist Professor of Taipei Medical University
7. Since July 2004
Associate Professor in Department of Thoracic Medicine,
Lin-Kou Medical Center of Chang Gung Memorial Hospital
8. July 2003 – July 2005
1

Chief of Department of Thoracic Medicine II, Lin-Kou
Medical Center of Chang Gung Memorial Hospital
9. Since August 2005
Director of Research, Education and Development Center.
Department of Thoracic Medicine, Lin-Kou Medical Center
of Chang Gung Memorial Hospital
10. Since August 2005
Associate Professor of Chang Gung University
BOARD CERTIFICATION 1. Since December 1989
Medical doctor, R.O.C.
Certification No.: 醫 字 第 018590 號
2. Since January 1993
Medical specialist in internal medicine, R.O.C.
Certification No.: 內 專 醫 字 第 003506 號
3. Since November 1994
Specialist in Thoracic Medicine, R.O.C.
Certification No.: 台 胸 學 會 證 字 第 0314 號
4. Since October 1998
Specialist in Critical Care Medicine, R.O.C.
Certification No.: 重 症 專 醫 字 第 0473 號
4. Specialist in Lung Cancer Society, Taiwan.
5. Since August 2000
Assist Professor. 助 理 字 第 004920 號
6. Since August 2005
Associate Professor. 副 字 第 033021 號
LICENSURES
Chinese License No.: 桃 衛 醫 執 字 第 2510 號 執 照
PROFESSIONAL
AFFILIATION 1. Member of the Society of Internal Medicine, R.O.C.
Since June 1993
Certification No.: 內 醫 證 字 第 3378 號
2. Member of Formosan Medical Association
3. Member of the Society of Pulmonary and Critical Care
Medicine, R.O.C.
4. Member of Society of Emergency and Critical care Medicine,
ROC.
5. Member of Society of Critical Medicine.
6. Member of the Society of Ultrasound in Medicine, R.O.C.
7. Member of the Taiwan Lung Cancer Society
8. Member of American Thoracic Society (A.T.S.)
9. Member of European Respiratory Society (E.R.S.)
10. Member of Taiwan Aerosol Associety
RESEARCH INTEREST
Thoracic medicine, Critical care medicine, Airway inflammation.
HONOR Award of Bioscience Research, National Science Council 1998
Award of Bioscience Research, National Science Council 1999
Award of Bioscience Research, National Science Council 2000
Best Chart Recording Attending Physician 2001.
2

Inclusion in Marquis Who's Who in the World 2007 (the
25th Anniversary Edition of Who's Who in the World)
Invited speaker in 16th Congress of Interasma Japan/North
Asia (2006, Tokyo)
Invited speaker in 3rd Chinese Health Platform Conference
(2006, Macao)
Invited speaker in “Air-Way Disease Symposium” (2007,
Taipei)
Invited speaker in “Transdidciplinary collaboration for
better health care: Dialogue and integration between
nursing and other disciplines” (2007, Chang Gung
University, TaoYuan)
Invited speaker in “Asia Pacific Speaker’s Forum – Better
Asthma Control” (2007, Beijing China)
Invited speaker in “Aisa Pacific COPD Submmit” (2007,
Taipei)
Invited speaker in “Asthma Forum” (2007, Nanjing China)
Invited speaker in “2007 Ruijin International Forum on
Respiratory Diseases and 1 st Meeting of ANSORP
Shanghai Network” (2007, Shanghai)
BIBLIOGRAPHY
Publications:
1. Lin HC, Wang CH, Yang CT, Huang TJ, Yu CT, Shieh WB, Kuo HP. Effect of Nasal
Continuous Positive Airway Pressure on Methacholine induced Bronchoconstriction.
Respiratory Medicine 1995; 89: 121-128. SCI
2. Lin MC, Lin HC, Lan RS, Tsao CT Thomas, Tsai YH, Chuang ML, Huang CC. Emergent
Fiberoptic Bronchoscopy fot the Evaluation of Acute Upper Chest Trauma. Journal of
Bronchoscopy 1995; 2: 188-191.
3. Yu CT, Wang CH, Huang TJ, Lin HC, Kuo HP. Relationship of BAL T-lymphocyte
subpopulations to rate of regression of active pulmonary tuberculosis. Thorax 1995; 50: 869-
874. SCI
4. Lee CH, Lin HC. Descriptive Study of Prognostic Factors influcing Survival of Patients with
Primary Tracheal Tumors. Chang-Gung Medical Journal 1995; 18: 224-130.
5. Yang CT, Lin HC, Lin MC, Wang CH, Lee CH, Kuo HP. Effect of 2-Agonist on Plasma
Potassium and Cardiopulmonary Responses on Exercise in Patients with Chronic Obstructive
Pulmonary Disease. Eur J Clin Pharmco 1996; 49: 341-345. SCI
6. Wang CH, Lin HC, Yang CT, Yu CT, Kuo HP. The effect of nasal continuous positive airway
pressure on upper and lower airway obstruction. Eur Respir J 1996; 9: 952-959. SCI
7. Kuo HP, Wang CH, Yu CT, Lin HC. Increased CD11b/CD18 on alveolar macrophages in
patients with active pulmonary tuberculosis. Tubercle and Lung Disease 1996; 77: 468-475.
SCI
8. Ho SC, Kao CH, Lin HC, Kuo HP. The clinical application of forced expiration technique in
patients with mucus hypersecretion. The J Nursing 1997; 44: 73-77.
9. Kuo HP, Hwang KH, Lin HC, Wang CH, Lu LC. Effect of endogenous nitric oxide on tumour
necrosis factor--induced leukosequestration and IL-8 release in guinea-pigs airways in vivo.
British J Pharmaco. 1997; 122: 103-111. SCI
10. Lin HC, Cheng HF, Wang CH, Liu CY, Yu CT, Kuo HP. Inhaled Gentamicin Reduces Airway
Neutrophil Activity and Mucus Secretion in Bronchiectasis. Am J Respir Crit Care Med; 1997;
155: 2024-2029. SCI
3

11. Liu CY, Wang CH, Chen TC, Lin HC, Yu CT, Kuo HP. Increased level of exhaled nitric oxide
and upregulation of nitric oxide synthase in alveolar macrophage in patients with primary lung
cancer. British Journal of Cancer 1998; 78: 534-541. SCI
12. Wang CH, Liu CY, Lin HC, Yu CT, Chung KF, Kuo HP. Increased exhaled nitric oxide in
active pulmonary tuberculosis due to inducible nitric oxide synthase upregulation in alveolar
macrophage. Eur Respir J 1998; 11: 809-815. SCI
13. Wang CH, Yu CT, Lin HC, Liu CY, Kuo HP. Hypodense alveolar macrophages in patients
with diabetes mellitus and active pulmonary tuberculosis. Tuber Lung Dis 1999, 79: 235-42.
14. Kuo HP, Hwang KH, Lin HC, Wang CH, Liu CY, Yu CT. Lipopolysaccharide enhances
neurogenic plasma exudaion in airways in guinea pigs. British J Pharmaco. 1998; 125: 711-
716. SCI
15. Hung TC, Lin HC, Lin KJ, Kuo HP. 131 Xenon ventilation scan as a functional assessment in
with bronchiectasis. Chang-Gung Medical Journal 1998: 21 (4): 403-408.
16. Hsieh WY, Yu CT, Wang CH, Lin HC, Liu CY, Kuo HP. The anti-inflammatory effect of a
long-acting theophylline (Unidur) in patients with bronchial asthma. Thorac Med. 1998; 13
(2): 96-105.
17. Chen HC, Liu CY, Wang CH, Lin HC, Kuo HP. Density heterogeneity of alveolar
macrophages: induction of hypodense alveolar macrophages by respiratory burst activation.
Thorac Med. 1998; 13: 214-224.
18. Huang CD, Huang KH, Lin HC, Wang CH, Kuo HP. Neutrophil adherence to lung epithelial
cells to induce interleukin-8 (IL-8) release. Chang-Gung Medical Journal 1999; 22: 392-399.
19. Wang CH, Hsieh WY, Shih LY, Lin HC, Liu CY, Chung KF, Kuo HP. Increased progenitor
cell proliferation in the peripheral blood of patients with bronchial asthma, the role of nitric
oxide. J Allergy Clin Immunol 1999; 104: 803-810. SCI
20. Ho SC, Chiang LL, Cheng HF, Lin HC, Sheng DF, Kuo HP, Lin HC. (Correspondant author)
The Effect of Incentive Spirometry on Chest Expansion and Breathing Work in Patients with
Chronic Obstructive Airway Diseases: Comparison of Two Method. Chang-Gung Medical
Journal 2000; 23: 73-79.
21. Lin HC, Wang CH, Liu CY, Yu CT, Kuo HP. Erythromycin inhibits 2-integrins
(CD11b/CD18) expression, interleukin-8 release and intracellular oxidative metabolism in
neutrophils. Respiratory Medicine 2000; 94: 654-660. SCI. (NSC 89-2314-B-182A-035)
22. Kuo HP, Wang CH, Lin HC, Yu CT, Liu CY, Hwang KH. Endogenous nitric oxide mediates
interleukin-, tumor necrosis factor- synthesis and release from alveolar macrophages in
patients with active pulmonary tuberculosis. Am J Respir Crit Care Med; 2000; 161: 192-9.
SCI
23. Lin SM, Hwang KH, Lin HC, Wang CH, Liu CY, Yu CT, Kuo HP. Lipopolysaccharide
enhances neurogenic plasma exudaion in trachea in guinea pigs. Chang-Gung Medical Journal
2000; 23 (1):14-21.
24. Ho SC, Chiang LL, Cheng HF, Sheng DF, Hung TC, Kuo HP, Lin HC. A Pulmonary
Rehabilitation Programme Improves Lung Functional Capacity and Reduces Hospital Care
Cost in Patients with Chronic Obstructive Airway Disease (COAD) and Mucus Hypersecretion.
(Correspondance author) Thoracic Medicine 2000; 15: 13-21.
25. Hsiao CJ, Tang CC, Chen H, Wang CH, Yu CT, Kuo HP, Lin HC. The Value of
Transbronchial Lung Biopsy in the Diagnosis of Peripheral Lung Tumours According to Cell
Type. (Correspondance author) Chang-Gung Medical Journal 2000; 23 (10): 584-589.
26. Tang CC, Hsiao CJ, Chen H, Wang CH, Lin HC, Yu CT, Kuo HP. Value of Broncoalveolar
lavage combined with transbronchial lung biopsy in the Diagnosis of Peripheral Lung cancer.
Chang-Gung Medical Journal 2000; 23 (11): 695-700.
27. Kuo HP, Lin HC, Hwang KH, Wang CH, Lu LH. Lipopolysaccharide enhances substance P-
mediated neutrophil adherence to epithelial cells and cytokines release. Am J Respir Crit Care
Med; 2000; 162: 1-7. SCI
28. Lin HC, Chiang, Lin HC, Yu CT. Immediate effect of trunk exercises in patients with chronic
obstructive pulmonary disease-comparison between pursed lip expiration and sustained
4

maximal inspiration. Formosan J Physical Therapy (FJPT) 2000; 25 (5): 284-291.
29. Lin HC, Wang CH, Yu CT, Liu CY, Kuo HP. Endogenous Nitric Oxide Inhibits Neutrophil
Adherence to Lung Epithelial Cells to Modulate Interleukin-8 Release Life Sciences 2001; 69:
1333-1344. SCI (NSC 88-2314-B-182A-039)
30. Chiang LL, Ho SC, Cheng HF, Sheng DF, Lin HC, Kuo HP. Relation of six-minute walking
with pulmonary function and ventilatory drive in patients with airway flow limitation.
(Correspondance author) Chang-Gung Medical Journal 2001; 24 (3): 159-166.
31. Wang CH, Lin HC, Liu CY, et al. Upregulation of inducible nitric oxide synthase and cytokine
secretion in peripheral blood monocytes from pulmonary tuberculosis patients. Int J Tuberc
Lung Dis (France), Mar 2001, 5(3) p283-91. SCI
32. Yang CK, Hung TC, Huang SF, Lin HC, Kuo HP. Rheumatoid arthritis with porphyria and
bilateral upper lobe opacities- an unusual presentation of bronchiolitis obliterans-organizing
pneumonia. (Correspondance author) Thoracic Medicine 2001; 16 (1): 66-72.
33. Hsiao HS, Lee KY, Lin HC, Huang SF, Kuo HP. Maignant Pleural Mesothelioma Appearing
as A Bronchogenic Malignancy on Chest radiography and Fluorescence Bronchoscopy: A
Case Report. (Correspondance author) Thoracic Medicine 2001; 16: 256-263.
34. Kuo HP. Wang CH. Lin HC. Hwang KS. Liu SL. Chung KF. Interleukin-5 in growth and
differentiation of blood eosinophil progenitors in asthma: effect of glucocorticoids. British
Journal of Pharmacology. 134(7):1539-47, 2001. SCI
35. Chiang LL, Hung TC, Ho SC, Lin HC, Yu CT, Wang CH, Kuo HP. Respiratory responses to
carbon dioxide stimulation during low flow supplemental oxygen therapy in chronic
obstructive pulmonary disease. J Formos Med Assoc 2002; 101: 607-15. SCI.
36. Su JC, Lo YL, Lin MH, Shen TY, Cheng CH, Lin HC, Kuo HP, Chen HC. Respiratory effort
and ventilatory drive in obstructive sleep apnea. Thoracic Medicine 2002; 17: 331-339.
37. Yu CT, Lin HC, Wang CH, Hwang KS, Liu CY, Kuo HP. Augmented Effect of Hyperoxia and
Tumour Necrosis Factor- on leukosequestration and Pro-inflammatory Cytokines Release in
Rat Airways. (Correspondance author) Thoracic Medicine 2002; 17: 354-363.
38. Tsao TC. Chiou W. Lin HC. Wu T. Lin M. Yang P. Tsai Y. Change in demographic picture
and increase of drug resistance in pulmonary tuberculosis in a 10-year interval in Taiwan.
Infection. 30(2):75-80, 2002. SCI.
39. Lin HC, Wang CH, Yu CT, Hwang KS, Kuo HP. Effect of Endogenous Nitric Oxide on
Hyperoxia and Tumour Necrosis Factor- - induced leukosequestration and Pro-inflammatory
CytokinesRelease in Rat Airways. Critical Care Medicine. 2003. 31(2): 508-516. SCI. (NSC
90-2314-B-182A-046)
40. Wang CH, Lin HC, Lin CH, Yu CT, Liu SL, Huang KH, Chung KF, Kuo HP. Effect of
theophylline and specific phosphodiesterase IV inhibition on proliferation and apoptosis of
progenitor cells in bronchial asthma. Br J Pharmacol 2003 Mar; 138(6): 1147-1155. SCI.
41. Ho SC, Sheng DF, Cheng HF, Chiang LL, Kuo HP, Lin HC. A home walking rehabilitation
program improves exercise tolerance and dyspnea sensation in patients with chronic
obstructive airway disease (COAD). (Correspondance author) Thoracic Medicine 2003; 18:
228-237.
42. Shen TY, Cheng CH, Yu CT, Liu CY, Wang CH, Lin HC, Kuo HP, Chou CL. (2003). The
long-term effects of inhaled corticosteroids treatment in near-fatal asthma patients. Thorac
Med; 18:44-52.
43. Cheng CS, Lin HC, Wang CH, Kuo HP. Primary Leiomyosarcoma Presenting as an
Endobronchial Mass and Synchronizing with Primary Lung Carcinoma: A Case Report.
Thoracic Medicine 2003; 18: 91-96.
44. Lin MS, Su JC, Lin HC, Wang CH, Chiang LL, Kuo HP. Different Mechanisms of Airway
Hyperresponsiveness between Exercise and Methacholine-Induced Bronchoconstiction in
Chronic Asthma. Thoracic Medicine 2003; 18: 116-123.
45. Lin HC, Tang CC, Hwang KS, Kuo HP, Yu CT. Simple Washing Compared to Dithiothreitol
(DTT) Method as a Better Method to Preserve Neutrophil Activity in Induced sputum.
Thoracic Medicine 2003; 18: 132-140.
5

46. Yang MC, Liu WT, Lin HC, Huang CJ, Huang SF, Kuo HP. Churg-Strauss Syndrome after
Corticosteroid Withdrawal in Asthma Patients- Report of two cases not related to leukotriene
receptor antagonists. Thoracic Medicine 2003; 18: 251-258.
47. Maa SH, Wang CH, Liu CY, Lin HC, Huang KH, Kuo HP. Endogenous nitric oxide
downregulates the Bcl-2 expression of eosinophils through mitogen-activated protein kinase in
bronchial asthma. J Allergy Clin Immunol 2003; 112: 761-767. SCI.
48. Chou PC, Lin CL, Liu WT, Lin HC, Kuo HP. Safety of the Methacholine Challenge Test in
Patients with Severe Airway Obstruction. Thoracic Medicine 2003; 18: 329-337.
49. Maa SH, Sun MF, Hsu KH, Hung TJ, Chen HC, Yu CT, Wang CH, Lin HC. Effect of
acupuncture or acupressure on quality of life of patients with chronic obstructive asthma: a
pilot study. The J Alternative and Complementary medicine 2003; 9 (5): 659-670. SCI.
50. Liu,C-Y., Liu,Y-H., Lin, S.-M., Yu, C.-T., Wang,C.-H., Lin, H.-C., Lin, C.-H., Kuo ,H.-P.
Apoptotic Neutrophils Undergoing Secondary Necrosis Induce Human Lung Epithelial Cell
Detachment. J. of Bio.Sci. 2003 10:746-756. SCI.
51. Huang CJ, Wang CH, Liu WT, Yang MC, Lin HC, Yu CT, Shiao CJ, Tan CC, Yang CK, Kuo
HP. Zafirlukast improves pulmonary function in patients with moderate persistent asthma
receiving regular inhaled steroids: a prospective randomized control study. Chang Gung Med J.
2003 Aug; 26 (8):554-60.
52. Chiang LL, Liu CY, Yu CT, Ho SC, Cheng HF, Sheng DF, Liu CY, Lin HC, Kuo HP.
Efficacy of nocturnal nasal positive pressure ventilation in hypercapnic patients with severe
obstructive lung disease. (Correspondance author) Chang-Gung Medical Journal 2004; 27 (2):
98-106.
53. Huang CD, Chen HH, Wang CH, Chou CL, Lin SM, Lin HC, Kuo HP. Human neutrophilderived
elastase induces airway smooth muscle cell proliferation. Life Sciences 2004;74:2479-
92. SCI.
54. Liu CY, Chuang PI, Chou CL, Lin SM, Chen HC, Chou PC, Liu YH, Yu CT, Wang CH, Lin
HC, and Kuo HP. Cytoprotective Response of A1, a Bcl-2 Homologue Expressed in Mature
Human Neutrophils and Promyelocytic HL60 Cells, against Oxidant Stress-Induced Cell Death.
J Biomed Sci 2004; 11: 214-227. SCI
55. Chen HC, Lin HC, Liu CY, Wang CH, Hwang T, Huang TT, Lin CH, Kuo HP. Neutrophil
elastase induces IL-8 synthesis by lung epithelial cells via the mitogen-activated protein kinase
pathway. J Biomed Sci. 2004 Jan-Feb; 11(1):49-58. SCI
56. Chiang LL, Wu YT, Wang LY, Lin HC, Lee CN. Effects of Domiciliary Nocturnal Ventilatory
Support in Patients with Chronic Respiratory Failure. Thoracic Medicine 2004; 19: 10-17.
57. Yang MC, Liu WT, Wang CH, Lin HC, Chen HC, Chou CL, Hsueh S, Kuo HP. Diagnostic
value of endobronchial ultrasound-guided transbronchial lung biopsy in peripheral lung
cancers. J Formos Med Assoc. 2004; 103 (2):124-9. SCI.
58. Ueng SH, Liu HP, Wu YC, Tsai YH, Lin HC, Ln MC, Lim KE, Huang SF. Pulmonary
lymphangioleiomyomatosis: A clinicopathological analysis of ten cases. Chang-Gung Medical
Journal 2004; 27 (3): 201-209.
59. Liu WT, Yang MC, Huang CJ, Lin HC, Wang CH, Kuo HP. Predicting value of abdominal
perfusion pressure and plasma renin activity in mechanically ventilated patients. Thoracic
Medicine 2004; 19: 99-108.
60. Yang CK, Lin HC, Lee KY, Lin SM, Yu CT, Kuo HP. The Effect of Ciprofloxacin on Chest
Radiographic Regression in Patients with Drug Intolerant or Resistant Tuberculosis.
(Correspondance author) Chang-Gung Medical Journal 2004; 27 (4): 292-299.
61. Lu YY, Ng SH, Cheung YC, Lui KW, Chan SC, Lin HC. Concomitant pulmonary and
mediastinal sclerosing haemangiomas. Br J Radiol. 2004 May; 77(917):438-40. SCI.
62. Huang PY, Fang YF, Hsieh MH, Lin HC. Bronchiectasis Complicated with Endobronchial
Actinomycosis - A Case Report and a Review of the Literature. (Correspondance author)
Thoracic Medicine 2004; 19: 373-381.
63. Lin SM, Liu CY, Wang CH, Lin HC, Huang CD, Huang PY, Fang YF, Hsieh MH, Kuo HP.
The impact of delirium on the survival of mechanically ventilated patients. Crit Care Med
6

2004; 32: 2254-59 SCI.
64. Hsieh MH, Lo YL, Fang YF, Huang PY, Kuo HP, Lin HC. Late-onset Central Alveolar
Hypoventilation Syndrome in a Patient with Hemorrhagic Brainstem Lesion and Improved
after Medroxyprogesterone Treatment. (Correspondance author) Thoracic Medicine 2005; 20:
220-26.
65. Fang YF, Chou CL, Huang CR, Huang PY, Hsieh MH, Lin HC. Bronchoscopy-Guided
Bedside Percutaneous Dilatational Tracheostomy versus Surgical Tracheostomy in Intensivecare
Patients. (Correspondance author) Thoracic Medicine 2005; 20:101-109.
66. Huang CD, Wang CH, Liu CY, Lin SM, Chou CL, Liu WT, Lin HC, Kuo HP. Eosinophils
from Asthmatics Releases IL-5 in an Autocrine Fashion to Prevent Apoptosis Through
Upregulation of Bcl-2 Expression. J Asthma 2005; 42:395-403 SCI.
67. Wang CH, Liu CY, Wan YL, Chou CL, Huang KH, Lin HC, Lin SM, LinTY, Chung KF,
Kuo HP. Persistence of lung inflammatory and lung cytokines with high-resolution CT
abnormalities during recovery from SARS Respir Res.2005 May 11;6(1):42 SCI.
68. Maa SH, Hung TJ, Hsu KH, Hsieh YI, Wang KY, Wang CH, and Lin HC. Manual
Hyperinflation Improves Alveolar Recruitment in Difficult-to-Wean Patients. Chest, Oct 2005;
128: 2714 - 2721. SCI.
69. Huang CJ and Lin HC. Association between Adrenal Insufficiency and Ventilator Weaning.
(Correspondance author) Am. J. Respir. Crit. Care Med. 2006 Feb; 173: 276-280. SCI.
70. Chen HC, Wang CJ, Chou CL, Lin SM, Huang CD, Lin TY, Wang CH, Lin HC, Yu CT, Kuo
HP, Liu CY. Tumor necrosis factor- induces caspase-independent cell death in human
neutrophils via reactive oxidants and associated with calpain activity. J Biomed Sci. 2006 Jan
13:261-273. SCI.
71. Hsieh MH, Wang CH, Liu CY, Yu CT, Lin HC. Erythromycin modulates 2-integrins
(CD11b/CD18) expression and intracellular oxidant capacity in airway neutrophils of patients
with bronchiectasis. (Correspondance author) Thoracic Medicine 2005; 20:503-516.
72. Lin CY, Shih JF, Perng DW, Lin HC, Wang CH , Yu CT, Chu Z, Liu YC. Mucolytic property
of a sustained-release ambroxol (Loxol SR ® ) in patients with cbronic bronchitis. Thoracic
Medicine 2005; 20:530-540.
73. Wang CJ, Chang ML, Wang YM, Lin TY, Lin HC. Life-threatening Pulmonary Hemorrhage
due to Cytomegalovirus Pneumonitis in a Patient with Chronic Myeloid Leukemia and Stem
Cell Transplantation Failure. (Correspondance author) Thoracic Medicine 2005; 20:633-641.
74. Lin TY, Huang CJ, Lin HC. Massive subcutaneous emphysema after Bronchoscopy-Guided
Ciaglia Blue Rhino percutaneous dilatational tracheostomy- 2 cases report. (Correspondance
author) J Formos Med Assoc 2005, 104: 942-945. SCI.
75. Wang YM, Lin SM, Wang CJ, Lin TY, Kuo HP, Lin HC. The Diagnosis and Clinical
outcomes of Patients with Sepsis-induced Disseminated Intravascular Coagulation in a
Medical Intensive Care Unit (Correspondance author) Thoracic Medicine 2006; 21: 157-167.
76. Chang ML, Lin HC. Spontaneous Closure of Tracheal Fistula caused by Descending
Necrotizing Mediastinitis in a Diabetic Patient – A Case Report and Review of Literature
(Correspondance author) Thoracic Medicine 2006; 21: 75-81.
77. Lin HC and Huang CJ. Association between Adrenal Insufficiency and Ventilator Weaning
Am. J. Respir. Crit. Care Med., April 15, 2006; 173(8): 934a - 935. SCI.
78. Huang CJ and Lin HC. Adrenal Insufficiency and Ventilator Weaning: Additional Study Is
Required (Correspondance author) Am J Respir Crit Care Med. 2006; 173:1176a-1176a. SCI.
79. Chiang LL, Yu CT, Liu CY, Lo YL, Kuo HP, Lin HC. Long-term Nocturnal Nasal Positive
Pressure Ventilation Improves Respiratory Muscle Capacity and Exercise Endurance in
Patients with Chronic Hypercapnic Respiratory Failure. (Correspondance author) J Formos
Med Assoc 2006; 105(6):459–467. SCI.
80. Chung FT, Kuo CH, Chang PJ, Lo CY, Wang CW, Liu YC, Lin HC. Congenital Cystic
Adenomatoid Malformation in Adult: A Case Report & Review of
Literature.(Correspondance author) Thoracic Medicine 2006; 21: 291-297.
81. Lee KY, Ho SC, Lin HC, Lin SM, Liu CY, Huang CD, Wang CH, Chung KF, Kuo HP.
7

Neutrophil-Derived Elastase Induces TGF- 1 Secretion in Human Airway Smooth Muscle via
NF-B Pathway. Am. J. Respir. Cell Molecular Biology 2006 Oct; 35(4):407-14. SCI
82. Lin SM, Huang CD, Lin HC, Wang CH, Liu CY, Kuo HP. A Modified Goal-directed Protocol
Improves Clinical Outcomes in Patients with Septic Shock: A Randomized Controlled Trial.
Shock 2006 : 26(6):551-557 SCI.
83. Chang PJ, Hsieh MH, Lo YL, Lo CY, Chung FT, Kuo CH, Lin HC. Comparison of
Somnologica 3 computerized Polysomnographic Systems Analysis and Manual Assessment of
Sleep Apnea. (Correspondance author) Thoracic Medicine 2006; 21: 313-320.
84. Lo CY, Wang CW, Fang YU, Hsieh, MH, Chang PJ, Chung FT, Kuo CH, Lin HC. Wegener’s
Granulomatosis Presenting as Breast Masses in a Patient with Sjogrene Syndrome.
(Correspondance author) Thoracic Medicine 2006; 21: 369-375.
85. Lo CY, Lin SM, Kuo AJ, Chung FT, Chang PJ, Kuo CS, Lin HC, Kuo HP. Clinical
Characteristics and Outcome in Patients with Pneumococcal Empyema. (Correspondance
author) Thoracic Medicine 2006; 21: 413-421.
86. Chung FT, Lin HC. Amoxicillin Modulates Leukosequestration and Proinflammatory
Cytokine Release in Airway of Patients with Bronchiectasis. (Co-first author)
(Correspondance author) Thoracic Medicine 2006; 21: 392-405.
87. Su CL, Chiang LL, Chiang TY, Yu CT, Kuo HP, Lin HC. Effects of Domiciliary Positive
Expiratory Pressure on Pulmonary Function and Exercise Capacity in Patients with Chronic
Obstructive Pulmonary Disease. (Correspondance author) J Formos Med Assoc 2007;
106(3):204–211. SCI.
88. Maa SH, Tsou TS, Wang KY, Wang CH, Lin HC, and Huang YH. Self-administered
Acupressure Reduces the Symptoms that Limit Daily Activities in Bronchiectasis Patients:
Pilot Study Findings. Journal of Clinical Nursing 2007; 16 (4), 794–804. SCI.
89. Kuo CH, Lin HC, Yu CT, Kuo HP. Multiple Myeloma Associated with Osteosclerotic Bone
Lesion Presenting as Chest Wall Masses. Thoracic Medicine 2007; 22: 86-91.
90. Liu CY, Lin HC, Yu CT, Lin SM, Lee KY, Chen HC, Chou CL, Huang CD, Chou PC, Liu
WT, Wang CH, Kuo HP. The concentration-dependent chemokine release and pro-apoptotic
effects of neutrophil-derived a-defensin-1 on human bronchial and alveolar epithelial cells.
Life Sci. 2007; 80(8):749-58. SCI.
91. Chou CL, Chiang LL, Yu CT, Chen HC, Lin SM, Huang CD, Liu WT, Chou PC, Wang CH,
Lin HC, Kuo HP, Liu CY (2006). Apoptosis-dependent and -independent mechanisms mediate
the phagocytic recognition/clearance of the HL60-A1 transfectants of prolonged survival.
Inflamm Res. 2007; (56): 195-203. SCI.
92. Lin TY, Lin SM, Chen HC, Wang CJ, Wang YM, Chang ML, Wang CH, Liu CY, Lin HC, Tu
CT, Hsieh LL, Kuo HP, Huang CD. An Open-label, Randomized Comparison of Levofloxacin
and Amoxicillin/Clavulanate plus Clarithromycin for the Treatment of Hospitalized Patients
with Community-acquired Pneumonia. Chang Gung Med J 2007;30:321-31.
93. Chan CC, Lin HC, Diffuse Endobronchial Kaposi’s Sarcoma in a Patient with Human
Immunodeficiency Virus Infection -A case report and Literature review. (Correspondance
author) Thoracic Medicine 2007; 22: 344-350.
94. Lin SM, Lin HC, Lee KY, Huang CD, Liu CY, Wang CH, Kuo HP. Ventilator-induced injury
augments interleukin-1beta production and neutrophil sequestration in lipopolysaccharidetreated
lungs. Shock. 2007 Oct; 28(4):453-60. SCI.
95. Huang CJ, Chan KY, Lee MY, Hsu LH, Chu NM, Feng AC, Yu CT, Lin HC. Computed
tomography characteristics of primary pulmonary lymphoepithelioma-like carcinoma. Br J
Radiol. 2007; 80, 803–806. SCI
96. Lin SM, Wang YM, Lin HC, Lee KY, Huang CD, Liu CY, Wang CH, Kuo HP. Serum
Thrombomodulin Level Relates to the Clinical Course of Disseminated Intravascular
Coagulation, Multi-organ Dysfunction Syndrome and Mortality in Patients with Sepsis.
Critical Care Medicine. 2007; SCI (accept for publication)
97. Kuo HP, Wang YM, Wang CH, He CC, Lin SM, Lin HC, Liu CY, Huang KH, Hsieh LL,
Huang CD. Matrix metalloproteinase-1 polymorphism in Taiwanese patients with
8

endobronchial tuberculosis. Tuberculosis SCI (Accepted for publication)
98. Chung FT, Lin SM, Kuo HP, Lin HC. The Impact of Extravascular Lung Water on the
Outcome of Severe Sepsis Patients in Medical Intensive Care Unit. Respiratory Medicine
2007 (accept for publication) SCI.
99. Lin SM, Lin TY, Chou CL, Chen HC, Liu CY, Wang CH, Lin HC, Yu CT, Lee KY, Kuo HP.
Metallic Stent and Flexible Bronchoscopy without Fluoroscopy for Acute Respiratory Failure.
Eur Respir J. 2008 Jan 9; [Epub ahead of print] SCI
Presentations:
1. Lin HC, Lin MC, Lan RS, Tsai YH. Emergent Fiberoptic Bronchoscopy in Emergency Room
for Evaluation of Acute Upper Chest Trauma. Thoracic Med 1992; 7: P35
2. Lin HC, Lin CH, Teng CM, Kuo HP. Pletlet-Activity Factor (PAF)-induced Production and
Enchancement of Nitric Oxide (NO) Generation by Guinea-Pig Bronchoalveolar Cells. Thorac
Med 1993; 8; O-16
3. Wang, C.H., Lin, H.C., Huang, T.J., Yang, C.T., Kuo, H.P. The effect of nasal continuous
positive airway pressure on upper and lower airway obstruction. Am Rev Respir Dis 1994;
149:A643. Annual Meeting of American Thoracic Society Boston, USA; May
4. Lin HC, Wang CH, Yang CT, Huang TJ, Yu CT, Shieh WB, Kuo HP. Effect of Nasal
Continuous Positive Airway Pressure on Methacholine induced Bronchoconstriction. Thorac
Med 1994; 9; O-62
5. Lin HC, Wang CH, Yang CT, Huang TJ, Yu CT, Shieh WB, Kuo HP. Effect of Nasal
Continuous Positive Airway Pressure on Methacholine induced Bronchoconstriction. Am Rev
Respir Dis 1995; 152: A423.
6. Wang, C.H., Ho, T.J., Lin, H.C., Yang, C.T., Yu, C.T., Kuo, H.P. Increased expression of
CD11b/CD18 on alveolar macrophages (AM) and its association with intracellular hydrogen
peroxide production in patients with pulmonary tuberculosis. Am J Respir Crit Care Med,
Seattle, Washington, 1995; 151: A246.
7. Lin, H.C., Wang, C.H., Huang, T.J., Yang, C.T., Yu, C.T., Shieh, W. B., Kuo, H.P. Effect of
nasal continuous positive airway pressure on methacholine-induced bronchoconstriction. Am J
Respir Crit Care Med, Seattle, Washington, 1995; 151: A398.
8. Lin HC, Cheng HF, Wang CH, Liu CY, Yu CT, Shieh WB, Kuo HP. The Effect of
Aerosolizedd Gentamicin on Airway Neutrophil Activity and Mucus Hypersecretion in
Patients with Bronchiectasis. Eur Respir J 1995; 8; 390S Annual Meeting of European
Respiratory Society. Bacelona, September 1995
9. Cheng HF, Lin HC, Yu CT, Shieh WB, Kuo HP. The Effect of Aerosolized Alkaline Soilution
onn Patients with Bronchiectasis. Eur Respir J 1995; 8; 390S Annual Meeting of European
Respiratory Society Bacelona, September 1995
10. Wang, C.H., Yu, C.T., Lin, H.C., Liu, C.Y., Kuo, H.P. CD4/CD8 ratio in bronchoalveolar
lavage and disease extent depend on PPD positivity in diabetic patients with active pulmonary
tuberculosis. Eur Respir J. Stockholm, Sweden, 1996; 9(supplement 23): 241s.
11. Effect Erythromycin upregulates the b2-integrins (CD11b/CD18) expression and intracellular
oxidants capacity of neutrophils in patients with bronchiectasis. World Conference of
Bronchology. Taiwan, April 1996.
12. Lin HC, Wang CH, Liu CY, Yu CT, Kuo HP. Erythromycin upregulates the expression of
CD11b/CD18 and oxidants on neutrophils in Patients with Bronchiectasis. Eur Respir J.
Stockholm, Sweden, Sep. 1996. (ORAL PRESENTATION)
13. Lin HC, Wang CH, Liu CY, Yu CT, Kuo HP. Amoxicillin downregulates the cytokines and
C5 in Patients with Bronchiectasis. Eur Respir J. Stockholm, Sweden, Sep. 1996. (ORAL
PRESENTATION)
14. Chen HC, Lin HC, Wang CH, Liu CY, Yu CT, Kuo HP. The effect of gentamicin on
neutrophil in vitro. Thoracic Med. Taipei, Taiwan, Dec, 1997
9

15. Lin HC, Wang CH, Liu CY, Yu CT, Kuo HP. The effect of gentamicin on neutrophil function
in response to lipopolysaccharide. Am J Respir Crit Care Med. San Francisco, USA, May,
1997.
16. Wu MH, Hung KS, Lin HC, Kuo HP. Repeated washing (RW) method, a better method to
preserve neutrophil function. Am J Respir Crit Care Med. San Francisco, USA, May, 1997.
17. Yu CT, Wu MS., Liu CY, Wang CH, Lin HC, Kuo HP.. Regulation of intracellular eosiophilic
cationic protein (ECP) expression by IL-3,IL-5 and GM-CSF in bronchial asthma. Am J Respir
Crit Care Med. 155: A887. San Francisco, USA, May, 1997
18. Wang CH, Liu CY, Lin HC, Yu CT, Kuo HP.. Upregulation of inducible nitric oxide synthase
(iNOS) from alveolar macrophage (AM) and increased level of exhaled nitric oxide (NO) in
patients with active pulmonary tuberculosis (TB). Am J Respir Crit Care Med. 155: A335. San
Francisco, USA, May, 1997
19. Liu CY, Wang CH, Lin HC, Yu CT, Kuo HP. Upregulation of inducible nitric oxide synthase
(iNOS) from alveolar macrophage (AM) and increased level of exhaled nitric oxide (NO) in
patients with primary lung cancer. Am J Respir Crit Care Med. 155: A797. San Francisco,
USA, May, 1997
20. Lin HC, Wang CH, Liu CY, Yu CT, Kuo HP. Aerosolized gentamicin downregulates
CD11b/CD18 expression ans intracellular oxidant production in airway neutrophils of patients
with bronchiectasis. P0440. Eur Respir J. Berlin, Germany, Sep, 1997
21. Wang CH, Liu CY, Lin HC, Yu CT, Kuo HP. Upregulation of inducible nitric oxide synthase
(iNOS) expression and enhanced production of nitrite in alveolar macrophages (AM) from
patients with active pulmonary tuberculosis. P2880. Eur Respir J. Berlin, Germany, Sep, 1997
22. Huang CD, Liu, C.Y., Wang, C.H., Lin, H.C., Yu, C.T., Kuo, H.P. Localization of nitric oxide
synthase in the lung of inflammatory and infectious diseases. Thoracic Medicine 1997; 12: F21
23. Lin SM, Wang, C.H., Lin, H.C., Liu, C.Y., Yu, C.T., Kuo, H.P. Lipopolysaccharide (LPS)
potentiate substance P (SP) to induce neutrophil adherence to epithelial cells and interleukin
1 (IL-) and tumor necrosis factor- (TNF-) release. Thoracic Medicine 1997; 12: F22
24. Chou CL, Lin, H.C., Wang, C.H., Liu, C.Y., Yu, C.T., Kuo, H.P. Neutrophil adherence to
epithelial cell mediates interleukin-8 (IL-8) release. Thoracic Medicine 1997; 12: F23
25. Hung TC, Lin, H.C., Wang, C.H., Liu, C.Y., Yu, C.T., Kuo, H.P. Xenon 133 ventilation scan
as a functional assessment in bronchiectasis patients. Thoracic Medicine 1997; 12: F05.
26. Lin, H.C., Wang, C.H., Liu, C.T., Yu, C.T., Kuo, H.P. Neutrophil adherence to epithelial cell
mediates interleukin-8 release. Am J Respir Crit Care Med , Chicago, Illinois, 1998; 157:
A202
27. Hung TC, Lin HC, Wang, C.H., Yu, C.T., Kuo, H.P. 131 Xenon ventilation scan as a functional
assessment in bronchiectasis patients. Am J Respir Crit Care Med , Chicago, Illinois, 1998;
157: A316
28. Wang, C.H., Lin HC, Yu, C.T., Kuo, H.P. Lipopolysaccharide (LPS) potentiates substance P
(SP) to induce neutrophil adherence to epithelial cells and interleukin1 (IL-1) and tumor
necrosis factor- (TNF-) release. Am J Respir Crit Care Med , Chicago, Illinois, 1998; 157:
A419.
29. Kuo, H.P., Lin HC, Wang, C.H., Liu, T.C. Hyperoxia enhances neutrophil adherence to
epithelial cell via enhancement of the expression of intercellular adhesion molecule (ICAM) –1.
Am J Respir Crit Care Med , Chicago, Illinois, 1998; 157: A420.
30. Ho, S.C., Chiang, L.L. Chern, H.F. Sheng, D.F, Lin, H.T. Lin HC, Kuo, H.P. A home
pulmonary rehabilitation program reduces hospital care cost and improves functional capacity
in patients with chronic obstructive airway diseases (COAD) with mucus hypersecretion. Eur
Respir J. 12 (suppl 28): 169S. Geneva, Switzerland.
31. Kuo, H.P., Wang, C.H., Huang, K.S., Lin HC, Wu, M.S. Nitric oxide (NO) mediates
interleukin1 (IL-1) and tumor necrosis factor- (TNF-) production in alveolar
macrophages of patients with pulmonary tuberculosis. Eur Respir J. 12 (suppl 28): 220S.
Geneva, Switzerland.
10

32. Hsieh, W.Y. Wang, C.H., Yu, C.T., Liu, C.Y., Lin HC, Kuo, H.P. Increased number of
progenitor cells in the peripheral blood (PB) of patients with bronchial asthma. Eur Respir J.
12 (suppl 28): 329S. Geneva, Switzerland.
33. Lin, H.C., Wang, C.H., Liu, C.T., Yu, C.T., Kuo, H.P. Nitric oxide (NO) attenuates neutrophil
adhesion to epithelial cell by inhibiting pro-inflammatory cytokines (interleukin-8 and tumor
necrosis factor-) release from epithelial cells. Eur Respir J. 12 (suppl 28): 421S . Geneva,
Switzerland.
34. Liu CY, Wang CH, Lin HC, Yu CT and Kuo HP. Differential regulation of iNOS expression
in inflammatory and infectious lung diseases. Am J Respir Crit Care Med 159:A104.
International Conference of American Thoracic Society, San Diego, Caliofrnia, USA. May 23-
28, 1999. (POSTER).
35. Huang CD, Liu CY, Wang CH, Lin HC, Yu CT and Kuo HP. Autocrine effect of interleukin 5
on granulocyte apoptosis in patients with asthma. Am J Respir Crit Care Med 159:A452.
International Conference of American Thoracic Society, San Diego, Caliofrnia, USA. May 23-
28, 1999. (POSTER).
36. Yu CT, Lin HC, Liu CY, Huang TT, Wang CH, Kuo HP. Cigarette smoke exposure induces
neutrophil adherence to airway epithelial cells and interleukin-8 release. Am J Respir Crit Care
Med 159:A181. International Conference of American Thoracic Society, San Diego, Caliofrnia,
USA. May 23-28, 1999. (POSTER)
37. Wang CH, Hsei WY, Lin HC, Liu CY, Chuang KF, Kuo HP. Dexamethasone suppresses
eosinophil colony formation from progenitor cells of peripheral blood in asthmatic patients by
dow-regulation of c-kit expression. Am J Respir Crit Care Med 159:A329. International
Conference of American Thoracic Society, San Diego, Caliofrnia, USA. May 23-28, 1999.
38. Chou CL, Wang CH, Hsei WY, Shih LY, Lin HC, Liu CY, Chuang KF, Kuo HP. Nitric oxide
inhibits progenitor cell proliferation in the peripheral blood of patients with bronchial asthma.
Am J Respir Crit Care Med 159:A744. International Conference of American Thoracic Society;
San Diego, Caliofrnia, USA; May 23-28, 1999. (ORAL)
39. Lin, H.C., Wang, C.H., Liu, C.T., Yu, C.T., Kuo, H.P. Acute cigarette smoke influences iNOS
production and Mac-I expression of airway neutrophils. Eur Respir J. 1999. Mariad, Spain.
40. Wang, C.H., Lin, H.C., Liu, S.L., Chung, K.F., Kuo, H.P. Theophylline inhibits progenitor cell
colony formation by accerating apoptosis in patients with bronchial asthma. Am J Respir Crit
Care Med, Toronto, Canada, 2000; 161: A336.
41. Cheng, H.F. Lin HC, Chiang, L.L. Ho, S.C., Sheng, D.F, Lin, H.C. Kuo, H.P. Effect of noninvasive
ventilation on exercise tolerance in patients with bronchiectasis: comparison between
negative ventilation (NV) and intermittent positive pressure ventilation (IPPV). Am J Respir
Crit Care Med, Toronto, Canada, 2000; 161: A496.
42. Kuo, H.P.Wang, C.H., Huang, K.S., Liu, S.L., Lin, H.C. Dexamethasone (Dexan) inhibits
progenitor cell growth and development by downregulating IL-5 synthesis. Am J Respir Crit
Care Med, Toronto, Canada, 2000; 161: A598.
43. Lin, H.C., Wang, C.H., Liu, C.T., Yu, C.T., Kuo, H.P, Synergic effect of hyperoxia and
tumour necrosis factor-α (TNF-α ) on the inducible nitric oxide synthase (iNOS) production
and cytokines (TNF-α and IL-1β ) release from airway neutophils. Eur Respir J. 2000.
Florence, Italy.
44. Tung C.C. Lin, H.C., Wang, C.H., Liu, C.T., Yu, C.T., Kuo, H.P, Neutrophil elastase induces
interleukin-8 (IL-8) release from epithelial cells via activation of nuclear transcription factorkappa
B (NF-B). Eur Respir J. 2000. Florence, Italy.
45. Shen T.Y., Lin, H.C., Wang, C.H., Liu, C.T., Yu, C.T., Kuo, H.P. Neutrophil Defensin Induces
Interleukin-8 (IL-8) Release from Epithelial cells via Activation of MAP kinase and Activated
Protein-1 (AP-1). Thoracic Medicine, 2000, Taipei.
46. Su J.C., Huang, K.H., Wang, C.H., Lin, H.C., Kuo, H.P, endogenous nitric oxide and ERK
kinase modulate the Bcl-2 expression of progenitor cells from bronchial asthma. Thoracic
Medicine, 2000, Taipei.
11

47. Liu CY, Wang CH, Lin HC, Yu CT, Kuo HP. Phagocytotic clearance of senescent HL60-A1
transfectants was mediated by apoptosis-independent mechanisms. Thoracic Medicine 16:F51.
Annual Conference of the Taiwan Society of Respiratory and Critical Care Medicine, Taiapei,
Taiwan. November 13, 2001. (ORAL)
48. Liu CY, Wang CH, Lin HC, Yu CT, Kuo HP. Antiapoptotic Bcl-2 homologue, A1, enhanced
phagocytic clearance of HL60 cells. Am J Respir Crit Care Med 165:A544. International
Conference of American Thoracic Society, Atlanta, Georgia, USA. May 15-22, 2002.
(POSTER)
49. Shen TY, Cheng CS, Yu CT, Liu CY, Wang CH, Lin HC, Kuo HP. The long-term effect of
inhaled corticosteroid treatment in near-fatal asthma patients. The 7th Congress of Asian
Pacific Society of Respirology: A121. Taipei, Taiwan. October 25-28, 2002. (ORAL)
50. Chou PC, Wang CH, Liu CY, Lin HC, Kuo HP. Heat shock protein (HSP) modulates the
proinflammatory cytokines release from alveolar macrophages of active pulmonary
tuberculosis. The 7th Congress of Asian Pacific Society of Respirology: A99. Taipei, Taiwan.
October 25 - 28, 2002 (ORAL)
51. Wang CH, Lin HC, Liu CY, Yu CT, Lin SM, Kuo HP. Increased ration of matrix
metalloproteinase-9 (MMP-9)/tissue inhinitor of metalloproteinase-1 (TIMP-1) in chronic
asthma with a greater decline in FEV1 in 5-year follow-up. Am J Respir Crit Care Med
167:A453. International Conference of American Thoracic Society, Seattle, Washington, USA.
May 16-21, 2003. (POSTER DISCUSSION).
52. Lin, H.C., Yu, C.T., Wang, C.H., Yang, C.K., Huang C.T., Huang J.T., Kuo, H.P, Thrombin
Activates Mitogen Activated Protein (MAP) kinase and Activated Protein-1 (AP-1) to Induce
Interleukin-8 (IL-8) Release from Airway Epithelial Cells. Eur Respir J. 2003. Vienna, Austria.
(ORAL PRESENTATION)
53. Yang, C.K., Lin, H.C., Huang J.T., Kuo, H.P, Intra-hemodialytic Hypotension Induces Tumour
Necrosis Factor- (TNF-) Production to Activate Neutrophil Mitogen-Activated Protein
Kinase (MAPK) in Critical Ill Patients. Eur Respir J. 2003. Vienna, Austria.
54. Wang, C.H., Lin HC, Yu, C.T., Kuo, H.P. Heat shock protein-70 modurates the proinflammatory
cytokines released from alveolar macrophages of active pulmonary tuberculosis.
Eur Respir J. 2003. Vienna, Austria.
55. Tung C.C. Yu, C.T., Kuo, H.P, Lin, H.C. Pleurodesis of malignant pleural effusion with
OK432. Eur Respir J. 2003. Vienna, Austria.
56. Huang CT, Lin, H.C, Yu CT, Huang JT, Kuo HP. Hyperoxia enhances Transforming Growth
Factor-beta 1 (TGF-1) Release from Lipopolysaccharide (LPS)-stimulated Airway Epithelial
Cells through a Activator Protein-1 (AP-1)-dependent Signaling Pathway. EB Societies. 2004.
57. Lin, H.C Peroxisome Proliferator-Activated Receptor (PPAR)-[gamma] Ligands Inhibit
Thrombin-Associated Inflammatory Cytokines Release from Alveolar Epithelial Cells Via
Histone H1 Activation and Cell Apoptosis. International Conference of American Thoracic
Society, San Diego, USA, 2006, A335.
58. Liu WT, Wang CH, Lin SM, Lin HC, Chou PC, Huang CD, Liu CY, Kuo HP. A new cellphone-based
exercise program for patients with chronic obstructive airway disease (COAD).
International Conference of American Thoracic Society, San Diego, USA, 2006, A269.
59. Huang CJ, Chu NM, Tsai YC, Liu CC, Hsu LH, Yu CT, Lin HC. Multimodality treatment of
Primary pulmonary lymphoepithelioma-like carcinoma. International Conference of American
Thoracic Society, San Diego, USA, 2006, A778.
Principle Investigator of Research Grants:
1. CMRP 570 Title: Effect of neutrophil interaction with airway epithelial cells in neutrophil
induced mucus hypersecretion - intervention by Macrolides and Aminoglycosides
Principle Investigator: Lin Horng-Chyuan
Duration: 1.1, 1996 ~ 12.31, 1998
12

2. CMRP 655 Title: Acute cigarette smoking influences endogenous oxidants to regulate the
neutrophil-mediated airway inflammation - intervention by immunohistochemistry
Principle Investigator: Lin Horng-Chyuan
Duration: 1.1, 1997 ~ 12.31, 1998.
3. NSC 88-2314-B-182A-039 Nitric oxide (NO) attenuates Neutrophil adhesion to Epithelial
Cells by inhibiting pro-inflammatory cytokines (Interleukin-8 and Tumor necrosis factor-)
release from epithelial cells
Principle Investigator: Lin Horng-Chyuan
Duration: 8.1, 1998 ~ 7.31, 1999
4. NSC 89-2314-B-182A-035 NF-kB activation by neutrophil adhesion to epithelial
cellsmediates inflammatory cytokines release: mechanism of anti-adhesive and antiinflammatory
properties of nitric oxide.
Principle Investigator: Lin Horng-Chyuan
Duration: 8.1, 1999 ~ 7.31, 2000
5. NSC 89-2314-B-182A-160 Activation of p38 MAP kinase and NF- kB mediates the IL-8
release from airway epithelial cells stimulated by neutrophil elastase
Principle Investigator: Lin Horng-Chyuan
Duration: 8.1, 2000 ~ 7.31, 2001.
6. CMRP-1177 A pulmonary rehabilitation program reduces hospital care cost in chronic
asthmatic patients
Co- Investigator: Lin Horng-Chyuan
Duration: 4.1, 2001 ~ 3.31, 2002.
7. NSC 90-2314-B-182A-046 Neutrophil Defensin Modulates IL-8 Release and Enhances
Apoptosis in Airway Epithelial cells via Activation of ERK MAP kinase and AP-1
Principle Investigator: Lin Horng-Chyuan
Duration: 8.1, 2001 ~ 7.31, 2002.
8. NSC 91-2314-B-182A-036 Neutrophil Defensin Modulates IL-8 Release and Enhances
Apoptosis in Airway Epithelial cells via Activation of ERK MAP kinase and AP-1
Principle Investigator: Lin Horng-Chyuan
Duration: 8.1, 2002 ~ 7.31, 2003.
9. CMRPG32014S SARS 防 疫 專 案 計 劃 : 冠 狀 病 毒 侵 犯 呼 吸 道 表 皮 細 胞 之 免 疫 調
節 機 轉 (Immunomodulatory mechanisms for Cytopathic effect of Conoravirus on airway
epithelial cells)
Principle Investigator: Lin Horng-Chyuan
Duration: 6.1, 2003 ~ 5.31, 2004.
10. NSC 92-2314-B-182A-187 Thrombin Modulates IL-8 and Heat Shock Protein Production and
Enhances Actin Cytoskeletal Derangement in Airway Epithelial Cells via Regulation of
Protease-Activated Receptors, ERK MAP kinase and AP-1
Principle Investigator: Lin Horng-Chyuan
Duration: 8.1, 2003 ~ 7.31, 2004.
11. NSC 92-2314-B-182A-158 性 狀 辨 識 受 器 與 細 胞 內 訊 號 路 徑 對 敗 血 症 病 患 之 大 腸 桿 菌 吞
噬 作 用 影 響 的 機 轉
Co- Investigator: Lin Horng-Chyuan
Duration: 8.1, 2003 ~ 7.31, 2004.
12. NSC 93-2314-B-182A-143 Hyperoxia induces Transforming Growth Factor-beta 1 (TGF-b1)
and Matrix metalloproteinases (MMPs) Release from Airway Epithelial Cells to Modulate
Fibroblast Proliferation
Principle Investigator: Lin Horng-Chyuan
Duration: 8.1, 2004 ~ 7.31, 2005.
13. NSC 93-2314-B-182A-069 感 覺 性 神 經 在 呼 吸 器 導 致 之 肺 傷 害 扮 演 之 角 色
Co- Investigator: Lin Horng-Chyuan
Duration: 8.1, 2004 ~ 7.31, 2005.
13

14. NSC 93-2314-B-182 -078 指 針 對 呼 吸 器 治 療 的 成 效
Co- Investigator: Lin Horng-Chyuan
Duration: 8.1, 2004 ~ 7.31, 2005.
15. NSC 94-2314-B-182A-199 Peroxisome Proliferator-Activated Receptor (PPAR)-gamma
Ligands Inhibit Thrombin-associated Pro-inflammatory Cytokines Release from Alveolar
Epithelial Cells via Histone Acetylation and Apoptosis
Principle Investigator: Lin Horng-Chyuan
Duration: 8.1, 2005 ~ 7.31, 2006.
16. NSC 95-2314-B-182A-054 Nitric Oxide (NO) Augments Thrombin-associated Transforming
Growth Factor-1 (TGF-1) Release from A549 Alveolar Cells to Modulate Fibroblast
Proliferation, Phenotype Change and Matrix Metalloproteinase Production
Principle Investigator: Lin Horng-Chyuan
Duration: 8.1, 2006 ~ 7.31, 2007.
17. NSC 95-2314-B-182 -032-MY3
登 階 運 動 訓 練 對 阻 塞 性 睡 眠 呼 吸 中 止 症 候 群 患 者 心 肺 耐 力 與 睡 眠 狀 況 之 成 效
Co- Investigator: Lin Horng-Chyuan
Duration: 8.1, 2006 ~ 7.31, 2009.
18. XMRPG350671
比 較 TG-873870 與 Levofloxacin 對 於 社 區 感 染 肺 炎 的 成 年 患 者 其 安 全 性 與 療 效 的 多 中 心 ,
隨 機 分 組 , 雙 盲 的 研 究
Principle Investigator: Lin Horng-Chyuan
Duration: 12.10, 2006 ~ 12.09, 2007.
19. 行 政 院 衛 生 署 疾 病 管 制 局 研 究 計 畫
院 內 感 染 控 制 介 入 評 估 研 究 整 合 型 計 畫 (Cost Benefit of Surveillance and Intervention
on Control of Nosocomial Infection)
子 計 畫 3 - 呼 吸 照 護 中 心 抗 藥 性 菌 種 監 測 及 感 染 管 制 介 入 措 施 之 效 益 評 估
Principle Investigator: Lin Horng-Chyuan
Duration: 01.01, 2007 ~ 12.31, 2007.
20. CMRPG360561 Nitirc Oxide (NO) Modulates Vascular Endothelial Growth
Factor (VEGF) Production and T-helper 1 (Th1)/ T-helper 2 (Th2) balance in Patients with
Bronchiectasis
Principle Investigator: Lin Horng-Chyuan
Duration: 6.1, 2007 ~ 5.31, 2008.
21. NSC 95-2314-B-182A-131 Neutrophil Proteases Regulate Balance between Airway
Inflammation and Epithelial-Mesenchymal Transition (EMT) of Airway Epithelial Cells – The
Role of Transforming Growth Factor-1 (TGF-1)
Principle Investigator: Lin Horng-Chyuan
Duration: 8.1, 2007 ~ 7.31, 2008.
22. CMRPG Virus Infection Induces Pulmonary Fibrogenesis by Modulation
of Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells – the Role of Transforming
Growth Factor-1
Principle Investigator: Lin Horng-Chyuan
Duration: 6.1, 2007 ~ 5.31, 2008.
專 書 及 專 書 論 文
慢 性 呼 吸 道 疾 病 – 支 氣 管 擴 張 症
作 者 :
林 鴻 銓 , 何 淑 娟
14

出 版 : 華 杏 出 版 股 份 有 限 公 司 (1997)
15

Professor Kian Fan Chung MD DSc FRCP
Professor Chung is Professor of Respiratory Medicine and Head of Experimental
Studies Unit at National Heart & Lung Institute, Imperial College London, and is an
Honorary Consultant Physician at the Royal Brompton Hospital, London. Professor
Chung trained in internal and respiratory medicine in Oxford and London, and did
postdoctoral training as MRC Visiting Scientist at the University of California in San
Francisco. He was awarded MD (1983) and DSc (2001) degrees from the University of
London, London, UK.
Professor Chung is a Senior Investigator of the UK National Institute for Health
Research. He is co‐leader of the IMI‐funded EU/EFPIA UBIOPRED project on Systems
Biology of severe asthma. He has received or in current receipt of research grants
from the Medical Research Council, The Wellcome Trust, US Health Effects Institute,
EU Innovative Medicines Initiative, National Environmental Research Council (UK),
Asthma UK and the National Institutes of Health.
Professor Chung currently serves on the editorial boards of several respiratory and
pharmacological journals. He has authored and co‐authored more than 750 scientific
articles, reviews and book chapters, and edited/co‐edited 10 books