For vaccine - GLOBE NETWORK

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Pneumonia results Numbers of events in children less than 2 years Outcome Control group Hib <strong>vaccine</strong> group Clinical pneumonia 6179 6273 Any severe 932 975 pneumonia Pneumonia 1651 1657 hospital admission X-ray confirmed 330 361
Pneumonia results Incidences per 100,000 child-years in children less than 2 years Outcome Control group Hib <strong>vaccine</strong> group Preventable disease incidence Clinical pneumonia 39,516 37,954 1,561 (270 – 2,853) Any severe 5,460 5,196 264 (-101 - 629) pneumonia Pneumonia 4,518 4,345 -174 (-153 - 500) hospital admission X-ray confirmed 893 936 -43 (-185 - 98) Fatal pneumonia 1020 954 66 (-126-259)
Page 1 and 2: How to determine the effectiveness
Page 3 and 4: But difficult questions have arisen
Page 5 and 6: Bohol study of PCV‐11 • 12,194
Page 7 and 8: But difficult questions have arisen
Page 9 and 10: So the key questions are… • How
Page 11 and 12: Before and after… • Need consis
Page 13 and 14: ARI surveillance system Viet Nam Ta
Page 15 and 16: Seasonal Prevalence of Major Pediat
Page 17 and 18: Before and after ‐ conclusions
Page 19 and 20: Community controls • Usually matc
Page 21 and 22: Potential for bias • Community co
Page 23 and 24: Lau et al. Acta Paediatr 1995;84:17
Page 25 and 26: An Effectiveness Trial of Hib Vacci
Page 27 and 28: How to establish the effectiveness
Page 29: Lancet 2005;365:43‐52
Page 33 and 34: Consider country X • East Asia
Page 35 and 36: Phased introduction • Risks - May
Page 37 and 38: What of serotype replacement? • O
Page 39 and 40: IPD in high risk groups • Immunoc

For vaccine - GLOBE NETWORK

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