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Contents<br />

1 Objectives and introduction<br />

2 A message from Matthew Emmens<br />

4 Drug safety<br />

12 Responsible marketing<br />

18 Managing our products<br />

24 Report from Angus Russell<br />

26 CR Committee<br />

27 <strong>Shire</strong> as a business<br />

28 — People<br />

34 — Environmental, health and safety performance<br />

38 — Supply chain<br />

40 — Role in the community<br />

44 <strong>Shire</strong> trademarks<br />

Inside Back Cover — Where to find <strong>Shire</strong><br />

Our Corporate Responsibility (CR) objectives<br />

— Ensure we consistently live up to our values<br />

— Promote workforce diversity<br />

— Focus on leadership and management development for employees<br />

— Ensure delivery of high-quality Human Resources (HR) support for the business<br />

— Respect employees’ work/life balance<br />

— Continuous improvement in the provision of a safe and healthy workplace for employees<br />

— Develop global health and safety measures to allow us to set targets and assess performance<br />

— Support patient education in key disease areas in accordance with local country or practice codes<br />

— Provide medications on compassionate basis to those who cannot afford them where the country<br />

or practice allows it<br />

— Ensure marketing and selling practices are ethical and in line with local country regulatory guidelines<br />

— Minimize animal use and ensure humane treatment and high standards of animal care<br />

— Ensure all <strong>Shire</strong> sponsored trials are conducted under industry good practice standards and adhere to the<br />

ethical principles of the Declaration of Helsinki<br />

— Ensure highest standards of safety monitoring and reporting are applied for the protection of the subjects<br />

and patients enrolled in clinical studies<br />

— Ensure patients and subjects are informed about the principles and potential risks of the trials<br />

— Maintain an appropriate level of involvement for <strong>Shire</strong> within the communities it operates in<br />

— Collate information on the Company’s charitable actions and community initiatives annually<br />

— Improve internal awareness about the Company’s activities in the community and share best practice<br />

— Enhance employees’ opportunities to participate in community initiatives<br />

— Remain in compliance with local, state and federal Environment, Health & Safety (EH&S) regulations<br />

— Integrate a single EH&S management system<br />

— Meet or exceed the conditions for air emissions and wastewater discharge<br />

— Reduce the employee incident rate<br />

— Identify potential and means to improve office environmental practices<br />

— Encourage suppliers to embrace CR standards similar to our own and work with them to share best practice<br />

and help them improve if appropriate<br />

— Require all contractors and sub-contractors to comply with Occupational Safety and Health Administration<br />

(OSHA) and <strong>Shire</strong> safety standards

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