directory of the spanish nanotechnology community - Fundación ...

Nitbiosafe offers: Aggregation analysis and colloidal stability; Nonspecific adsorption of proteins;
SterilityTargeting; Phagocytosis assay; Oxidative Stress Study, Determination of the production of
reactive oxygen species; Cytotoxicity analysis of two methodologies (MTT, Quick Cell); Inflammation
Study: Production of cytokines; Complement activation test; Study of haematological parameters;
Biological characterization in vivo (Lethal Dose DL50, TDAR (T cell dependent antibody response);
Biodistribution and pharmacokinetics.
Conjugation / functionalization of NPs / nanomaterials / surfaces with biomolecules or drugs:
The research area of synthetic materials is approaching a new era of multifunctional materials. Today we
need materials with customizable functions, to be designed on demand, with a direct objective, let’s say
an intelligent design of functional materials. These multifunctional nanostructured systems are reaching a
great interest and development for improving different biosensors (human and animal health,
contaminants or toxins detection (environment, food, etc.), better medical imaging systems for early
identification of diseases, removal of tumors by hyperthermia, improving drug targeting and drug delivery,
increasing cosmetic products absorption, improving food packaging properties, improving the quality of
water for environmental applications, etc.
Nanoimmunotech has a vast experience and own protocols for the functionalization of different
biomolecules in an oriented way on the surface of different supports, guaranteeing the activity and
stability of these biomolecules.
Main related relevant activities/projects
Nanoimmunotech developed its own nanosystems functionalization / conjugation technology: nitzipper®.
It is a new revolutionary technology that allows to quickly, easily and effectively joining different types of
micro/nanostructures, biomolecules, dyes, linkers, drugs and many other molecules, in practically any
combination. Nitzipper® is also a multi-functionalization tool that allows joining more than one type of
molecule or micro/nanostructure to another molecule or micro/nanostructure.
nitzipper® may be used for a wide range of applications allowing to innovate within various markets and
sectors (biomedical, pharmaceutics, cosmetics, veterinary, agrofood, environmental, etc.).
Other information
The Nanoimmunotech business model is flexible and we have experience in participating in research or
on demand projects, licensing, customer-supplier relationships, etc.
As project example that Nanoimmunotech can add value in, we could mention our participation in the
project COLIVAC (INNTERCONECTA), for the improvement ofvaccines through the use of
nanotechnology.
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