Technetium radiopharmaceuticals

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Cold Kit Components • Chelating/Complexing agent • Reducing agent – usually stannous chloride • Inert atmosphere (vacuum, nitrogen) ◦ Why? • Stabiliser if required (ascorbic acid for MDP) • Usually in a lyophilised state (freeze dried) for stability
• The chelating agent usually donates lone pairs of electrons to form coordinate covalent bonds with reduced d 99mTc. Chemical groups such as —COO,—OH,—NH2, and—SH are the electron donors in compounds such as DTPA, gluceptate, and various proteins
Page 1 and 2: Technetium radiopharmaceuticals •
Page 3: What Are Cold Kits? o Non-radioacti
Page 8 and 9: Technetium radiopharmaceuticals
Page 11 and 12: preparation
Page 14 and 15: Preparation
Page 19: Preparation
Page 29 and 30: Tc-99m Labeled WBCs •Used for loc
Page 31 and 32: Tc-99m WBC Labeling Procedure • C
Page 39 and 40: Three Ways to Prepare Tc-99m RBCs
Page 41 and 42: In-Vivo Method •A kit of Sn-PYP i
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Radioiodine( 131 I, 123 I, 125 I)
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Protein labeling • Monochloride i
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• 125 I-Sodium Iothalamate
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Indium •ProductionP d • 111 Cd
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Other radionuclides • Thallium 20
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Technetium radiopharmaceuticals

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