2013 Quarter 1 - Australian Institute for Bioengineering and ...
2013 Quarter 1 - Australian Institute for Bioengineering and ...
2013 Quarter 1 - Australian Institute for Bioengineering and ...
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AIBN<br />
QUARTERLY<br />
Q1 <strong>2013</strong><br />
Director’s Message<br />
Professor Peter Gray<br />
AIBN Director<br />
As you will see on the following pages, AIBN has had a flying<br />
start to the year. Towards the end of January the AIBN Board,<br />
Chaired by Euan Murdoch, met <strong>for</strong> a full day at AIBN to<br />
discuss many of the issues of key importance <strong>for</strong> the institute,<br />
<strong>and</strong> engage in more detailed discussions with a number of<br />
our Group Leaders. We were delighted that UQ’s new Vice-<br />
Chancellor, Professor Peter Høj, was able to join the Board <strong>for</strong><br />
lunch. The Board meeting was followed by a retreat <strong>for</strong> our<br />
Group Leaders, Associate Group Leaders, <strong>and</strong> Section Heads<br />
where two days of presentations <strong>and</strong> robust discussion helped to<br />
<strong>for</strong>mulate institute strategies <strong>for</strong> the challenging year ahead.<br />
The following pages summarise some of the many visitors, events<br />
<strong>and</strong> achievements of our staff <strong>and</strong> students during the quarter.<br />
Together, the stories describe the rich spectrum of activities<br />
occurring in AIBN. I would however, like to mention one item<br />
of particular personal significance - the departure of Dr Trent<br />
Munro.<br />
Trent has been with us just on seven years, joining AIBN from<br />
Cambridge UK after a video conference interview with Donna<br />
Hannan <strong>and</strong> myself. His first job on arrival was to get ready to<br />
move into the new, still uncompleted building, <strong>and</strong> to set up the<br />
mammalian cell culture facilities on Level 3 West. Trent’s highlevel<br />
scientific abilities coupled with his management skills meant<br />
that he <strong>and</strong> his colleagues rapidly developed the area into labs<br />
which rank amongst the best in the world. He has been offered<br />
an excellent position as head of Cell Line Development at<br />
Amgen’s major Thous<strong>and</strong> Oaks facility north of Los Angeles, <strong>and</strong><br />
while we will certainly miss him, it is a great tribute to him <strong>and</strong> to<br />
the <strong>Institute</strong> that he has been offered such a prestigious position.<br />
aibn events<br />
11 April <strong>2013</strong><br />
Industrial Affiliates Program: Thought Leaders’ Dinner<br />
Series, Customs House, Brisbane<br />
18 April <strong>2013</strong><br />
UQ Global Leadership Series event with Professors Mark<br />
Kendall, Ian Frazer <strong>and</strong> Robert Booy: Improving The Reach<br />
Of Vaccines To The Developing World With Nanopatches,<br />
Customs House, Brisbane<br />
8 September <strong>2013</strong><br />
2 nd International Conference on BioNano Innovation, Beijing,<br />
China<br />
Editorial Contributions<br />
Janice Besch<br />
Erik de Wit<br />
Petrina Gilmore<br />
Peter Gray<br />
Darius Koreis<br />
Design<br />
Darius Koreis<br />
In this issue<br />
1 - Director’s message<br />
2 - AIBN signs Korean cooperation agreement<br />
2 - DSM executives meet at AIBN<br />
2 - AIBN Group Leader a <strong>2013</strong> <strong>Australian</strong><br />
Academy of Science Fellow<br />
2 - Research the best hope <strong>for</strong> spinal injuries<br />
3 - Researchers get their h<strong>and</strong>s dirty in the name<br />
of going green<br />
3 - $375,000 regenerative medicine boost<br />
4 - Accolade <strong>for</strong> student’s design in vaccine<br />
research<br />
4 - Research aims to diagnose without blood tests<br />
5 - AIBN provides leadership in national research<br />
administrator accreditation project<br />
5 - Leading journal appointment shows AIBN’s<br />
strength<br />
5 - Award win <strong>for</strong> protein trouble-shooter<br />
5 - AIBN news briefs<br />
6-7 - PhD Focus - Alex<strong>and</strong>ra Depelsenaire<br />
8 - AIBN Seminar Series - <strong>2013</strong> Semester 1<br />
9 - Donate to AIBN<br />
AIBN <strong>Quarter</strong>ly<br />
Photography<br />
Erik de Wit<br />
Joe Vittorio<br />
Have you got news?<br />
Won an award?<br />
Had a paper published?<br />
Contact us<br />
p.gilmore@uq.edu.au<br />
d.koreis@uq.edu.au<br />
For news as it happens visit<br />
us online www.aibn.uq.edu.au<br />
Or follow us on Twitter<br />
@AIBN_DIRECTOR<br />
And add us to Facebook<br />
QUARTERLY<br />
1
News<br />
AIBN signs Korean cooperation<br />
agreement<br />
An agreement between the AIBN <strong>and</strong> the Center <strong>for</strong> Intelligent<br />
Nano-Bio Materials at the Ewha Womans University, Republic of<br />
Korea, was signed at the <strong>Institute</strong> on 4 March <strong>2013</strong>.<br />
The international agreement allows <strong>for</strong>:<br />
• Both institutions to establish a joint mechanism <strong>for</strong> the exchange<br />
of scholars;<br />
• Sharing <strong>and</strong> exchange of research materials <strong>for</strong> research <strong>and</strong><br />
educational purposes;<br />
• The promotion of joint research activities <strong>and</strong> participation in<br />
conferences, symposia, serial lectures <strong>and</strong> seminars.<br />
Executive Vice President of Ewha Womans University, Professor Jin-<br />
Ho Choy, travelled from Seoul to be the University’s representative<br />
at the signing, <strong>and</strong> also gave a presentation on the University’s<br />
capabilities.<br />
The signing of the agreement followed on from a visit by <strong>Australian</strong><br />
Governor-General <strong>and</strong> UQ Alumnus Ms Quentin Bryce AC CVO to<br />
Ewha Womans University only six days earlier.<br />
DSM executives meet at AIBN<br />
Two influential DSM executives met at the AIBN on 21 March.<br />
Ms Karen King, President of DSM Biologics, has previously visited<br />
the AIBN, however, Mr Stefan Doboczky, a Managing Board<br />
member overseeing the group of which Ms King is President, visited<br />
Brisbane <strong>for</strong> the first time <strong>and</strong> is the highest ranking DSM executive<br />
to have visited Australia.<br />
Mr Doboczky is a member of the five-person Managing Board<br />
of DSM, a blue chip global company active in Life Sciences <strong>and</strong><br />
Materials Sciences with a €9 billion annual turnover.<br />
AIBN is delighted that it has been possible to attract a company<br />
of the calibre of DSM Biologics to be the operator of the biologics<br />
scale-up facility currently being completed alongside the TRI<br />
building.<br />
Biologics are the fastest growing class of human therapeutic<br />
medicines, <strong>and</strong> the Queensl<strong>and</strong> facility is being built as the<br />
‘Biologics Plant of the Future’.<br />
While visiting the AIBN, Mr Doboczky held a meeting with AIBN<br />
Director Professor Peter Gray <strong>and</strong> toured the facilities.<br />
2<br />
QUARTERLY<br />
A large delegation from DSM<br />
visted the AIBN in August 2012<br />
AIBN Group Leader a <strong>2013</strong> <strong>Australian</strong><br />
Academy of Science Fellow<br />
Congratulations to The University of Queensl<strong>and</strong> Deputy Vice-<br />
Chancellor (Research) <strong>and</strong> AIBN Group Leader Professor Max Lu, who<br />
has been selected as <strong>2013</strong> <strong>Australian</strong> Academy of Science Fellow.<br />
Professor Lu is a world leading<br />
scientist in materials science <strong>and</strong><br />
chemical engineering, having made<br />
many significant <strong>and</strong> sustained<br />
contributions including the new<br />
method <strong>for</strong> synthesis of highly<br />
reactive single crystal TiO2.<br />
He has provided new insights into the<br />
surface chemistry <strong>and</strong> modifications<br />
of nanoporous materials, molecular<br />
engineering of membranes <strong>and</strong><br />
efficient photocatalyst <strong>for</strong> clean<br />
energy <strong>and</strong> water.<br />
> Click here <strong>for</strong> full story <<br />
Left to right: Dr Eve Tsai, Dr Fiona Filardo,<br />
Dr Bronwin Dargaville <strong>and</strong> Dr Firas Rasou<br />
Research the best hope <strong>for</strong> spinal<br />
injuries, symposium told<br />
A quadriplegic has urged scientists to keep up their research, saying<br />
even small steps could help make huge improvements to his life.<br />
Spinal Cord Injury Association Brisbane president David Riley spoke<br />
at a one-day symposium at the AIBN.<br />
“I don’t expect to be able to walk around or run around. It is the<br />
little things,” Mr Riley said.<br />
“If I could move one finger, I could drive a vehicle. If I could regain<br />
bowel control, it would give me a much improved quality of life,” he<br />
said.<br />
“I see research <strong>and</strong> a multidisciplinary approach as our best chance.<br />
“There is no cure in the short term. But we are hopeful with research<br />
that there will be improvements in the quality of our lives.”<br />
The symposium attracted speakers from all over the world, including<br />
University of Ottawa neurosurgeon <strong>and</strong> scientist Dr Eve Tsai.<br />
Dr Tsai is collaborating with AIBN’s Dr Firas Rasoul as part of a<br />
State Government’s National <strong>and</strong> International Research Alliance<br />
Program (NIRAP) grant.<br />
She used her trip to Australia to further their research into ways of<br />
stimulating the body to repair itself, provide stem cell therapies to<br />
regenerate <strong>and</strong> repair injured areas.<br />
“Stem cells are a very important area. There is huge potential,” she<br />
said.<br />
“Every dollar of funding could be used <strong>for</strong> work that could<br />
potentially make a huge contribution.<br />
“I go to work <strong>and</strong> see patients with spinal cord injuries. It seems such<br />
a tragedy. Some are so young. Typically, they had one moment of<br />
misjudging something <strong>and</strong> their lives are irrevocably changed <strong>for</strong>ever.”<br />
Dr Rasoul said his research involved designing biomaterials which<br />
could target injured spinal areas, stimulate cell regrowth <strong>and</strong><br />
encourage repairs.<br />
This complemented Dr Tsai’s work, which looked at how a patient<br />
would respond to the medicines or genes to ensure safe <strong>and</strong><br />
effective tissue repair or regrowth.<br />
> Click here <strong>for</strong> full story
News<br />
Left to right:<br />
Professors John<br />
Dorgan, Joe Greene<br />
<strong>and</strong> Peter Halley<br />
Researchers get h<strong>and</strong>s dirty in the name of going green<br />
Professor Peter Halley is working to rid Australia of plastic pollution<br />
through both research <strong>and</strong> elbow-grease.<br />
He is developing degradable plastics <strong>for</strong> agricultural films <strong>and</strong> food<br />
packaging, but Professor Halley is also making sure existing plastics<br />
do not pollute Brisbane’s parks <strong>and</strong> waterways with participation in<br />
Clean Up Australia Day.<br />
Taking part in the day will be two important US collaborators:<br />
Colorado School of Mines biopolymers expert Professor John<br />
Dorgan <strong>and</strong> Cali<strong>for</strong>nia State University biodegradation specialist<br />
Professor Joe Greene.<br />
“I think it is important <strong>for</strong> us to get our h<strong>and</strong>s dirty <strong>and</strong> remember<br />
why we are doing our research,” Professor Halley said.<br />
“It is about creating sustainable products <strong>and</strong> processes which<br />
minimise our effects on the planet.”<br />
With funding from industry <strong>and</strong> government, Professor Halley’s<br />
research group is developing environmentally-responsible plastics.<br />
Professor Dorgan brings experience in bioplastics research <strong>and</strong><br />
development <strong>and</strong> Professor Greene will provide biopolymer<br />
processing <strong>and</strong> biodegradation testing expertise from industry <strong>and</strong><br />
university.<br />
They have also developed green technologies <strong>for</strong> industry, such as<br />
Apple’s iTunes cards <strong>and</strong> specialised laboratory facilities enabling<br />
the study of biodegradation on l<strong>and</strong> <strong>and</strong> in marine parks.<br />
“I have been interested in recycling <strong>and</strong> reducing plastic waste since<br />
my PhD,” Professor Halley said.<br />
“Global population growth coupled to rapid economic development<br />
are increasing water, food <strong>and</strong> energy needs <strong>and</strong> putting enormous<br />
pressure on our environment.”<br />
Researcher’s $375,000 regenerative<br />
medicine boost<br />
Tissue engineer Dr Jess Frith will<br />
determine the role of specific<br />
molecules in cell development in<br />
world-first research, with plans to<br />
use the knowledge to repair bones<br />
<strong>and</strong> cartilage.<br />
Dr Frith will combine cells with<br />
biomaterials to reconstruct body<br />
tissues in the lab, on the path<br />
to one day potentially treating<br />
osteoporosis, osteoarthritis or<br />
intervertebral disc degeneration.<br />
Her work at the <strong>Australian</strong><br />
<strong>Institute</strong> <strong>for</strong> <strong>Bioengineering</strong> <strong>and</strong><br />
Nanotechnology, based at The<br />
University of Queensl<strong>and</strong>, has<br />
received a boost with the awarding<br />
of $375,000 in <strong>Australian</strong> Research<br />
Council Early Career Researcher<br />
Award funding <strong>for</strong> three years.<br />
“I think regenerative medicine has<br />
the potential to trans<strong>for</strong>m medicine<br />
in the future but a major hurdle in<br />
achieving this is our ability to make<br />
cells behave as we want,” she said.<br />
“The cells need to turn into the<br />
correct tissue type. Controlling<br />
this is difficult. We know that stem<br />
cells are very sensitive to the<br />
environment around them.”<br />
This is where Dr Frith’s research<br />
comes in, with plans to investigate<br />
whether molecules called<br />
microRNAs play an important role<br />
in how the response of cells to<br />
their environment determines cell<br />
development.<br />
“I will be using biomaterials to see<br />
if I can influence microRNAs <strong>and</strong><br />
see if I can push stem cells to <strong>for</strong>m<br />
specific tissues.”<br />
She also has a more personal<br />
reason <strong>for</strong> wanting to see advances<br />
in the field.<br />
“My mum has had a spinal fusion<br />
because of intervertebral disc<br />
problems. It was a major procedure<br />
<strong>and</strong> it still hasn’t really fully solved<br />
the problem.<br />
“I would like to think that my<br />
research will one day lead to an<br />
effective alternative, where we can<br />
tissue engineer replacement tissues<br />
that are fully functional.”<br />
QUARTERLY<br />
3
News<br />
Accolade <strong>for</strong> student’s design in vaccine<br />
research<br />
PhD student Stefano Meliga is using mathematical modelling to help develop<br />
a delivery system which is expected to one day vaccinate against a host of<br />
diseases without needle <strong>and</strong> syringe.<br />
The modelling simulates the application to skin of microscopic needles on a<br />
silicon wafer which can be coated with vaccines against key diseases including<br />
influenza, human papillomavirus, herpes simplex, West Nile <strong>and</strong> Chikungunya<br />
viruses.<br />
Design of the wafer, called the Nanopatch, has to be honed <strong>for</strong> use on human<br />
skin, ahead of clinical trials <strong>and</strong> possible roll-out around the world as a newgeneration<br />
vaccine delivery system.<br />
The work has been published this month in the prestigious Journal of Controlled<br />
Release, with Mr Meliga listed as first author.<br />
It adds to Engineers Australia’s National Committee on Applied Mechanics<br />
recognition of the work, with the Postgraduate Student Best Paper Award at the<br />
Australasian Congress of Applied Mechanics at the University of Adelaide.<br />
The $500 prize money will be used to travel to Singapore, where Mr Meliga<br />
plans to build collaborations with Dr Keng-Hwee Chiam at the <strong>Institute</strong> of high<br />
Per<strong>for</strong>mance Computing <strong>and</strong> Professor Victor Shim at the National University of<br />
Singapore – <strong>and</strong> secure validation of his research.<br />
Mr Meliga’s work also involves processing 3D fluorescence-microscopy images to<br />
investigate the transport of vaccine, delivered with the Nanopatch, in the skin.<br />
“I am keen to gain important insights into the penetration of the<br />
microprojections <strong>and</strong> the diffusion of the vaccine across the skin layers,” Mr<br />
Meliga said.<br />
“It is exciting to be involved in this work. The Nanopatch has the potential to<br />
save lives.<br />
“The mathematical skills I am using are fundamentally important <strong>for</strong> the<br />
development of new biomedical applications such as the Nanopatch.<br />
“Development of next-generation devices can’t be solely driven by engineering<br />
intuition. Mathematical modelling such as simulations can effectively drive<br />
experimental testing.<br />
“The satisfaction of finding out what experiments cannot show keeps me glued<br />
to my chair.”<br />
Research aims to diagnose without<br />
blood tests<br />
Dr Simon Corrie has started research on a way of detecting<br />
diseases without the need <strong>for</strong> blood tests or lab analysis, using<br />
$375,000 in <strong>Australian</strong> Research Council funding.<br />
Dr Corrie received an ARC Discovery Early Career Researcher<br />
Award to help in research that combines materials chemistry with<br />
molecular biology to determine if technology used <strong>for</strong> vaccine<br />
delivery device the Nanopatch can also be tailored <strong>for</strong> disease<br />
detection.<br />
He aims to prove that thous<strong>and</strong>s of microscopic needles on a small<br />
polymer wafer can be used to quickly detect biomarkers which<br />
point to the presence of infectious diseases such as dengue fever<br />
<strong>and</strong> malaria.<br />
The device will be designed to sit on the skin, draw in fluids to react<br />
with antibodies <strong>and</strong> reporter probes <strong>and</strong> turn a particular colour,<br />
similar to a litmus test, if biomarkers are present.<br />
“Diagnostic tests are crucially important in many areas of medicine.<br />
While billions of dollars are spent per year developing drugs <strong>for</strong><br />
treatment, only a fraction is spent on diagnostics,” Dr Corrie said.<br />
“However, early <strong>and</strong> accurate diagnosis of disease has proven time<br />
<strong>and</strong> again to drastically improve outcomes <strong>and</strong> survival.”<br />
The benefit of using the microscopic needles in diagnostics is that<br />
it could alleviate the need <strong>for</strong> hospital labs <strong>and</strong> long waits <strong>for</strong><br />
patients.<br />
“Currently diagnostics <strong>for</strong> infectious diseases are designed to be<br />
per<strong>for</strong>med in hospital labs, over the period of hours or days.<br />
“We expect the device to rapidly detect proteins or antibodies,<br />
without the need <strong>for</strong> highly trained health workers or access to<br />
scientific laboratories.<br />
“If the results could be made available immediately at the bedside,<br />
at a GP clinic or at home, this would greatly benefit patients,<br />
health care workers <strong>and</strong> probably reduce burdens on health care<br />
budgets.”<br />
4<br />
QUARTERLY
AIBN provides leadership<br />
in national research<br />
administrator accreditation<br />
project<br />
AIBN’s Deputy Director Operations, Janice Besch, has<br />
accepted the role of facilitating the development<br />
of a training <strong>and</strong> accreditation module on the<br />
National Research & Innovation System in Australia,<br />
as part of a larger project to set in place the <strong>for</strong>mal<br />
accreditation of <strong>Australian</strong> <strong>and</strong> New Zeal<strong>and</strong><br />
Research Administrators.<br />
The project is broad-reaching, with only one other<br />
professional accreditation system in existence<br />
internationally – the Research Administrators<br />
Certification Council (RACC) in the United States.<br />
The objective is to ensure that all of those people<br />
who decide on a career in support of the research<br />
enterprise are well briefed <strong>and</strong> maintain an up to<br />
date body of knowledge in the field.<br />
The lead agency <strong>for</strong> the project is the Australasian<br />
Research Management Society, <strong>and</strong> the Society has<br />
entered into an agreement to collaborate on this front<br />
with its American sister agency.<br />
The UK <strong>and</strong> Europe have already indicated support<br />
<strong>and</strong> potential involvement as collaborators in the<br />
system, adapted <strong>for</strong> their circumstances.<br />
Ten modules of the Accreditation Scheme are in<br />
development, with five considered fundamental to the<br />
research administrator’s body of knowledge.<br />
The module providing a broad underst<strong>and</strong>ing the<br />
National Research Innovation System in Australia will<br />
cover government policy <strong>and</strong> RISsupport <strong>for</strong> research,<br />
the role of funding agencies <strong>and</strong> other supporters of the<br />
system, <strong>and</strong> the research <strong>and</strong> innovation value chain.<br />
The advisory group brings together high-level<br />
representation from Federal <strong>and</strong> Queensl<strong>and</strong><br />
Government agencies responsible <strong>for</strong> research <strong>and</strong><br />
innovation; the National Health & Medical Research<br />
Council; the <strong>Australian</strong> Research Council; the <strong>Australian</strong><br />
Renewable Energy Agency; Universities <strong>and</strong> training<br />
providers.<br />
News<br />
Chancellor’s Award <strong>for</strong> Team<br />
Excellence<br />
Congratulations to the Protein<br />
Expression Facility team <strong>for</strong> winning<br />
The University of Queensl<strong>and</strong>’s<br />
<strong>2013</strong> Chancellor’s Award <strong>for</strong> Team<br />
Excellence.<br />
The team, comprised of Cindy Chang,<br />
Bradley Ryan, Christopher Munro<br />
<strong>and</strong> Emilyn Tan, were honoured at<br />
a ceremony by UQ Chancellor John<br />
Story <strong>and</strong> Vice-Chancellor Professor<br />
Peter Høj.<br />
The award was <strong>for</strong> the team’s<br />
long-st<strong>and</strong>ing commitment <strong>and</strong><br />
outst<strong>and</strong>ing contributions to advance<br />
the University’s st<strong>and</strong>ing as a worldclass<br />
higher education <strong>and</strong> research<br />
institution.<br />
> Click here <strong>for</strong> full story <<br />
Leading journal role shows<br />
AIBN’s strength<br />
AIBN Group Leader Professor Anton Middelberg<br />
has been appointed Associate Editor of the journal<br />
Vaccine.<br />
Vaccine is the pre-eminent journal <strong>for</strong> those<br />
interested in vaccines <strong>and</strong> vaccination.<br />
“This appointment provides recognition that<br />
AIBN, which is well known <strong>for</strong> its ef<strong>for</strong>ts in<br />
commercialising vaccine technology, has also<br />
achieved international recognition <strong>for</strong> its scholarly<br />
activities in the field of vaccine development,”<br />
Professor Middelberg said.<br />
“As an Editor of the leading Vaccine journal,<br />
responsible <strong>for</strong> manufacturing-related papers, I<br />
have direct dialogue with all new developments<br />
in this field, <strong>and</strong> help get this knowledge out from<br />
labs <strong>and</strong> into the worldwide research community,”<br />
he said.<br />
Professor Middelberg is the only <strong>Australian</strong>-based<br />
Editor of the journal.<br />
Other Associate Editors of the publication include<br />
Dr Robert Chen who is head of Vaccine Safety<br />
at the Atlanta-based Center <strong>for</strong> Disease Control<br />
(CDC), <strong>and</strong> Dr Albert Osterhaus from the Erasmus<br />
Medical Centre in the Netherl<strong>and</strong>s.<br />
Dr Osterhaus is one of the world’s leading<br />
virologists <strong>and</strong> his group was the first to identify<br />
human infection with the avian influenza strain<br />
H5N1.<br />
The appointment adds to Professor Middelberg’s<br />
other journal positions as Editor-in-Chief of<br />
Chemical Engineering Science, an Advisory Editorial<br />
Board Member of Trends in Biotechnology, <strong>and</strong><br />
Associate Editor of Biochemical Engineering Journal.<br />
Award win <strong>for</strong> protein<br />
trouble-shooter<br />
He may have only finished his studies 12 months ago,<br />
but Chris Munro is already making a mark in a field<br />
essential <strong>for</strong> developing new-generation vaccines <strong>and</strong><br />
targeted medicine delivery.<br />
The 23-year-old from Chermside produces protein at<br />
the Protein Expression Facility (PEF), housed at the AIBN.<br />
He has become so adept at overcoming challenges in<br />
the work that he has won an award at the Cambridge<br />
Healthtech <strong>Institute</strong> conference PepTalk at Palm<br />
Springs, Cali<strong>for</strong>nia in late January.<br />
“To attend a conference in Palm Springs <strong>and</strong> present<br />
our work was a fantastic opportunity,” Mr Munro said.<br />
“Being able to meet leading researchers from around<br />
the world, many of whom were interested in the work<br />
our facility does, was amazing.”<br />
Together with PEF colleagues, Mr Munro tailors<br />
protein from cells to suit the specific requirements of<br />
researchers so it can be used in vaccine development,<br />
drug discovery or stem cell research.<br />
The extracted protein is then subjected to different<br />
temperatures <strong>and</strong> nutrients to tailor it <strong>for</strong> the specific<br />
requirements.<br />
Protein is a building block used in many research<br />
fields, so Mr Munro’s work could be linked to future<br />
advances in regenerative medicine, vaccination,<br />
therapeutics <strong>and</strong> medicine delivery.<br />
“Finding solutions to the challenges involved in protein<br />
purification is very rewarding. It could be the first step<br />
in overcoming hurdles in disease research,” he said.<br />
“Overcoming them can enable more efficient,<br />
cheaper means of producing therapeutics.”<br />
PEF has a team of eight highly-skilled professionals<br />
producing protein <strong>for</strong> cutting-edge research, freeing<br />
up those in individual laboratories from a task that is<br />
otherwise too costly <strong>and</strong> labour-intensive.<br />
Home grown video<br />
Ever wondered what synthetic<br />
biology is but couldn’t cut through all<br />
the jargon?<br />
AIBN’s Dr Claudia Vickers, along<br />
with collaborators from the Royal<br />
<strong>Institute</strong> of Australia, created a short<br />
educational video that spells it out in<br />
easy to digest language.<br />
You can find out what synthetic<br />
biology is currently used <strong>for</strong>, <strong>and</strong><br />
why it is so important. Some of the<br />
answers might just surprise you...<br />
> Click here to view the video <<br />
Young Scientists of Australia<br />
experience AIBN<br />
20 high school students from across<br />
Queensl<strong>and</strong> visited AIBN on 23<br />
January <strong>2013</strong> as part of Young<br />
Scientists of Australia’s The Science<br />
Experience.<br />
The students gave up a week of their<br />
holidays to come to The University<br />
of Queensl<strong>and</strong> <strong>and</strong> experience what<br />
the University offers in science <strong>and</strong><br />
engineering.<br />
The students toured the AIBN<br />
facilities <strong>and</strong> were given lab<br />
demonstrations <strong>and</strong> the opportunity<br />
to make ice cream making using<br />
liquid nitrogen.<br />
$50,000 Pepfactants grant<br />
AIBN spin-out company Pepfactants<br />
has been awarded a $50,000<br />
Commercialisation Australia Skills &<br />
Knowledge grant.<br />
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5
PhD Focus<br />
PhDFocus<br />
Alex<strong>and</strong>ra Depelsenaire<br />
29-year-old Alex<strong>and</strong>ra Depelsenaire is in the final year of<br />
her PhD at the AIBN. The German-born student is working<br />
in Professor Mark Kendall’s lab, <strong>and</strong> discovering the impact<br />
that Nanopatch technology has on enhancing immune<br />
responses to vaccines delivered into the skin.<br />
After starting her research at the AIBN in 2009, the end of<br />
her studies is now in sight, <strong>and</strong> she speaks to us about her<br />
research <strong>and</strong> future direction.<br />
What is the title of your project?<br />
How does the localized <strong>and</strong> controlled cell death – invoked by<br />
Nanopatch application to skin – lead to the impaired immune<br />
responses of vaccines?<br />
In a nutshell, what does that mean?<br />
I investigate cellular damage <strong>and</strong> cell death following microneedle<br />
(Nanopatch) application. My results to date emphasise the<br />
immunological impact of damaged cells following vaccine delivery<br />
into the skin. This research is important because it shows <strong>for</strong> the<br />
first time the effect of cell damage generated by different dermal<br />
vaccine delivery devices, in particular microneedles, in conjunction<br />
with the resulting immune response.<br />
How do you go about your work?<br />
Following application of the Nanopatch to skin, I dissect <strong>and</strong> stain<br />
the tissue <strong>for</strong> live <strong>and</strong> dead cells. This tissue sample is then visualised<br />
under our Multiphoton <strong>and</strong> Laser Scanning Confocal microscope<br />
to capture images of the various cells types. I then quantify<br />
the live-dead ratio <strong>and</strong> examine the proximity between them.<br />
Alternatively, I process the skin tissue to extract proteins <strong>and</strong> analyse<br />
<strong>for</strong> particular proteins that are up-regulated in dead cells in<br />
comparison to untreated cells. In animal studies, mice are vaccinated<br />
by the Nanopatch or by a st<strong>and</strong>ard syringe intradermally <strong>and</strong> I<br />
cross-compare the resulting immune responses <strong>and</strong> levels of cell<br />
death between the different cutaneous vaccine delivery devices to<br />
identify a correlation between cell death <strong>and</strong> immunogenicity.<br />
How important are the results of your work <strong>for</strong> seeing the<br />
Nanopatch come to market?<br />
My work will assist in studying <strong>and</strong> - hopefully - advancing our<br />
knowledge base of the mechanism (or mode of action) of the<br />
Nanopatch, which is crucial <strong>for</strong> the human trials. This is key <strong>for</strong> the<br />
Nanopatch to advance as a clinical medical device product.<br />
At what stage are you in your project now?<br />
I’m in my final year, <strong>and</strong> hopefully submitting my thesis in the second<br />
half of this year.<br />
What problems have you encountered in your research?<br />
Doing a PhD includes studying <strong>and</strong> researching something that has<br />
never been done be<strong>for</strong>e. In particular, my work spans different<br />
disciplines, including Engineering <strong>and</strong> Biology, with a main emphasis<br />
on Cell Biology. Some of the imaging techniques have not previously<br />
been per<strong>for</strong>med, hence quite a lot of optimisation was required<br />
prior to obtaining any valuable data. Also, I used different stains<br />
to differentiate between live <strong>and</strong> dead cells; these stains however<br />
have not been fully investigated in skin tissue <strong>and</strong> this also required<br />
quite some tweaking. However, the hard work has paid off <strong>and</strong> my<br />
PhD project is bearing fruit now.<br />
If you could change one thing from the time you’ve been doing<br />
your PhD, what would it be?<br />
Preferably, I would have worked in this field or my current group<br />
The next step...<br />
Once you complete your PhD, what is your next step?<br />
Upon completion, I would like to stay in academia <strong>for</strong> a while to<br />
continue with my research. However, I am also keen on gaining industry<br />
experience. Covering these two fields would eventually enable me to<br />
become a patent attorney – or patent examiner – like my uncle <strong>and</strong><br />
my parents are. Having experience in academia <strong>and</strong> industry is highly<br />
regarded by potential employers.<br />
UQ offers a commercialisation course, which I would like to undertake<br />
to gain a first insight into the <strong>Australian</strong> commercialisation strategy<br />
<strong>and</strong> approach <strong>for</strong> patenting. A law course is not m<strong>and</strong>atory but would<br />
certainly be beneficial further downstream.<br />
So you’ve got commercialisation in your blood?<br />
Yes, I’d say so. My dad was a patent examiner <strong>and</strong> a patent attorney<br />
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PhD Focus<br />
Multiphoton <strong>and</strong> Confocal imaging of murine skin<br />
Nanopatches are applied to mouse ears <strong>and</strong> tissue collected at set<br />
time points after application. The tissue is prepared <strong>for</strong> viability<br />
staining to visualise live (green) <strong>and</strong> dead cells (magenta). This<br />
viability analysis is essential to investigate the impact of live <strong>and</strong><br />
dead cells in immune responses following vaccine delivery. Here, we<br />
show that the cell death is tightly localised around the Nanopatch<br />
projections penetrating the skin, co-localising with the vaccine<br />
diffusing off the projections.<br />
prior to starting my PhD as this would have saved me valuable time<br />
in optimising <strong>and</strong> learning new techniques.<br />
What was your background be<strong>for</strong>e starting at AIBN?<br />
I received my Bachelor of Science from Murdoch University (Perth,<br />
WA) as well as a Diploma in Biology by my German University,<br />
while my Honours included research in Nanotechnology (fabrication<br />
of alumina membranes <strong>for</strong> drug delivery).<br />
How do you feel about being involved in a project like the<br />
Nanopatch?<br />
It is a fantastic experience being part of such a multidisciplinary<br />
team like ours. When I started, all I wanted is to combine<br />
Nanotechnology <strong>and</strong> Biology; I didn’t have an idea how big the<br />
impact would be. Due to the large media coverage following our<br />
publications <strong>and</strong> various prizes that have been awarded because<br />
of the results or the promising ‘needle-free vaccine c<strong>and</strong>idate’, the<br />
Nanopatch is known far beyond UQ <strong>and</strong> Brisbane. When asked, <strong>for</strong><br />
instance, nurses, doctors, dentists <strong>and</strong> even hairdressers have heard<br />
of the Nanopatch <strong>and</strong> express great interest in its development.<br />
This feedback amongst conference or reviewed papers is the best<br />
reward <strong>for</strong> me; these comments make it worth staying back late in<br />
the lab... Now, three <strong>and</strong> a half years down the track, I indeed feel<br />
very <strong>for</strong>tunate working in such a multidisciplinary team alongside<br />
engineers, mathematical modellers, (bio-)chemists, biologists,<br />
vaccinologists, immunologists <strong>and</strong> virologists.<br />
How did you hear about AIBN <strong>and</strong> get started on your PhD?<br />
Bluntly, I just Googled ‘Bio <strong>and</strong> Nanotechnology Australia’. One<br />
of the top websites that came up was the AIBN. I looked through<br />
many groups <strong>and</strong> emailed several of the Group Leaders. Mark<br />
Kendall’s project on the Nanopatch sounded the most appealing to<br />
me. Following a visit to Brisbane <strong>and</strong> the research group, I applied<br />
<strong>for</strong> competitive international living <strong>and</strong> tuition scholarships. Once<br />
my scholarship application was approved, I moved from Perth to<br />
Brisbane.<br />
When you one day retire <strong>and</strong> have a chance to look back at your<br />
life, what would you like to say that you’ve accomplished?<br />
That my research has contributed to save or improve the life of at<br />
least one person; <strong>and</strong> that I was able to teach some useful things<br />
to the ‘students of today who will become the scientists of tomorrow’.<br />
who was director of the chemical engineering department at the European<br />
Patent Office (EPO) <strong>for</strong> approximately a decade prior to working as a<br />
consulting European Patent Attorney <strong>for</strong> Peugeot Citroen. My mum also<br />
worked over 10 years <strong>for</strong> the EPO as a patent examiner (chemistry) while<br />
my uncle worked <strong>for</strong> around 20 years <strong>for</strong> the EPO as patent examiner<br />
(electrical engineer) <strong>and</strong> is now a European Patent Attorney.<br />
In addition, I did some part time work after school <strong>for</strong> the EPO which<br />
involved indexing, scanning <strong>and</strong> recognising the various parts of<br />
international patent files.<br />
Has your work on the Nanopatch given an insight to the road to<br />
commercialisation that could be useful as a Patent Attorney?<br />
Yes. Working on the Nanopatch has given me the opportunity to see how<br />
important intellectual property protection can be. Without this in place,<br />
commercialisation could have been significantly impaired.<br />
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7
News<br />
Seminar Series<br />
Semester I, <strong>2013</strong><br />
<strong>2013</strong> AIBN Seminar Series Coordinator: Petrina Gilmore<br />
Enquiries: p.gilmore@uq.edu.au<br />
Parnell Building 7 - Room 222; 12:00-1:00pm, Thursdays<br />
MARCH<br />
THuRsdAy 7 MARCH<br />
AIBN GENERAL MEETING<br />
THuRsdAy 14 MARCH<br />
Professor Mark Kendall<br />
Group Leader, AIBN, The<br />
University of Queensl<strong>and</strong>;<br />
Director, Vaxxas<br />
Improving the reach of vaccines<br />
to the developing world with<br />
Nanopatches<br />
THuRsdAy 21 MARCH<br />
Professor John Dorgan<br />
Site Director, Colorado Center<br />
<strong>for</strong> Biorefining <strong>and</strong> Biofuels,<br />
Colorado School of Mines, USA<br />
Supramolecular<br />
EcoBioNanocomposites<br />
incorporating<br />
stereocomplexation<br />
THuRsdAy 28 MARCH<br />
Professor Jeff Gorman<br />
Group Leader, Protein Discovery<br />
Centre, Queensl<strong>and</strong> <strong>Institute</strong> of<br />
Medical Research (QIMR)<br />
Proteomic dissection of the<br />
battle between respiratory<br />
syncytial virus <strong>and</strong> epithelial<br />
cells during infection<br />
APRIL<br />
THuRsdAy 11 APRIL<br />
Professor Peter Halley<br />
Group Leader, AIBN, The<br />
University of Queensl<strong>and</strong><br />
Translational Polymer Research<br />
<strong>for</strong> Sustainable Polymers<br />
THuRsdAy 18 APRIL<br />
Professor Robert Booy<br />
Head of Clinical Research,<br />
National Centre <strong>for</strong><br />
Immunisation Research <strong>and</strong><br />
Surveillance (NCIRS), The<br />
University of Sydney<br />
Vaccine Scares <strong>and</strong> Successes<br />
THuRsdAy 25 APRIL<br />
ANZAC DAy PUBLIC HoLIDAy<br />
MAy<br />
THuRsdAy 2 MAy<br />
AIBN GENERAL MEETING<br />
THuRsdAy 9 MAy<br />
Professor Hiroaki Kitano<br />
Sir Louis Matheson<br />
Distinguished Professor,<br />
<strong>Australian</strong> Regenerative<br />
Medicine <strong>Institute</strong>, Monash<br />
University<br />
Systems biology in the context<br />
of systems <strong>and</strong> precision<br />
engineering<br />
THuRsdAy 16 MAy<br />
Professor Gordon Southam<br />
Vale-UQ Geomicrobiology<br />
Laboratory, The University of<br />
Queensl<strong>and</strong><br />
Biological <strong>and</strong> geological<br />
sciences<br />
THuRsdAy 23 MAy<br />
Dr Chris Elvin<br />
Senior Principal Research<br />
Scientist, CSIRo<br />
Molecular Biomimicry: Nature’s<br />
4 billion years of R&D<br />
THuRsdAy 30 MAy<br />
Emeritus Professor Jack<br />
Pettigrew<br />
Queensl<strong>and</strong> Brain <strong>Institute</strong>, The<br />
University of Queensl<strong>and</strong><br />
The Mystery of Bradshaw Rock<br />
Art<br />
JuNE<br />
THuRsdAy 6 JuNE<br />
AIBN GENERAL MEETING<br />
THuRsdAy 20 JuNE<br />
Professor Magnus Nydén<br />
Director, The Ian Wark Research<br />
<strong>Institute</strong>, University of South<br />
Australia<br />
New methods <strong>for</strong> predicting<br />
diffusion in porous materials<br />
<strong>and</strong> new technologies <strong>for</strong><br />
preventing biological growth at<br />
solid liquid interfaces<br />
THuRsdAy 27 JuNE<br />
SEMESTER FINISHED<br />
8<br />
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Invitation<br />
Did you know... In 2011 AIBN researchers<br />
published 275 peer-reviewed papers?<br />
FURTHER OUR RESEARCH<br />
Help support the <strong>Australian</strong><br />
<strong>Institute</strong> <strong>for</strong> <strong>Bioengineering</strong> <strong>and</strong><br />
Nanotechnology’s vital research.<br />
To donate, please visit:<br />
www.uq.edu.au/giving/aibn<br />
Donate in four key areas<br />
☐ AIBN Scholarships<br />
An AIBN scholarship donation will help nurture the next generation of research<br />
leaders to work towards improved human health, cleaner energies, better<br />
manufacturing practices <strong>and</strong> a sustainable environment.<br />
☐ Neutropaenia Research<br />
AIBN is working with the <strong>Australian</strong> Red Cross <strong>and</strong> Peter MacCallum Cancer<br />
Centre to address Neutropaenia infection in cancer patients undergoing<br />
chemotherapy. With around 200,000 people worldwide hospitalised every<br />
year, one in 14 will consequently die, making it the most common cause of<br />
treatment-related deaths in cancer patients.<br />
☐ AIBN Auditorium<br />
Your gift will allow AIBN researchers access to a world of ideas; facilitating<br />
multi-disciplinary research projects with a truly global outlook <strong>and</strong> the best<br />
chance at success.<br />
☐ AIBN General<br />
AIBN applies a multidisciplinary approach to underst<strong>and</strong>ing <strong>and</strong> exploiting<br />
nanostructures, the genetic basis of cell activity, <strong>and</strong> opportunities at the<br />
interface between bioengineering <strong>and</strong> nanotechnology.<br />
AIBN is building a nationally <strong>and</strong> internationally acknowledged <strong>Institute</strong> in sustained research excellence, with<br />
collaborative links to leading global research groups <strong>and</strong> corporations. New materials, devices <strong>and</strong> processes<br />
based on bioengineering <strong>and</strong> nanotechnology research will address health, energy <strong>and</strong> environmental issues.<br />
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