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AIBN<br />

QUARTERLY<br />

Q1 <strong>2013</strong><br />

Director’s Message<br />

Professor Peter Gray<br />

AIBN Director<br />

As you will see on the following pages, AIBN has had a flying<br />

start to the year. Towards the end of January the AIBN Board,<br />

Chaired by Euan Murdoch, met <strong>for</strong> a full day at AIBN to<br />

discuss many of the issues of key importance <strong>for</strong> the institute,<br />

<strong>and</strong> engage in more detailed discussions with a number of<br />

our Group Leaders. We were delighted that UQ’s new Vice-<br />

Chancellor, Professor Peter Høj, was able to join the Board <strong>for</strong><br />

lunch. The Board meeting was followed by a retreat <strong>for</strong> our<br />

Group Leaders, Associate Group Leaders, <strong>and</strong> Section Heads<br />

where two days of presentations <strong>and</strong> robust discussion helped to<br />

<strong>for</strong>mulate institute strategies <strong>for</strong> the challenging year ahead.<br />

The following pages summarise some of the many visitors, events<br />

<strong>and</strong> achievements of our staff <strong>and</strong> students during the quarter.<br />

Together, the stories describe the rich spectrum of activities<br />

occurring in AIBN. I would however, like to mention one item<br />

of particular personal significance - the departure of Dr Trent<br />

Munro.<br />

Trent has been with us just on seven years, joining AIBN from<br />

Cambridge UK after a video conference interview with Donna<br />

Hannan <strong>and</strong> myself. His first job on arrival was to get ready to<br />

move into the new, still uncompleted building, <strong>and</strong> to set up the<br />

mammalian cell culture facilities on Level 3 West. Trent’s highlevel<br />

scientific abilities coupled with his management skills meant<br />

that he <strong>and</strong> his colleagues rapidly developed the area into labs<br />

which rank amongst the best in the world. He has been offered<br />

an excellent position as head of Cell Line Development at<br />

Amgen’s major Thous<strong>and</strong> Oaks facility north of Los Angeles, <strong>and</strong><br />

while we will certainly miss him, it is a great tribute to him <strong>and</strong> to<br />

the <strong>Institute</strong> that he has been offered such a prestigious position.<br />

aibn events<br />

11 April <strong>2013</strong><br />

Industrial Affiliates Program: Thought Leaders’ Dinner<br />

Series, Customs House, Brisbane<br />

18 April <strong>2013</strong><br />

UQ Global Leadership Series event with Professors Mark<br />

Kendall, Ian Frazer <strong>and</strong> Robert Booy: Improving The Reach<br />

Of Vaccines To The Developing World With Nanopatches,<br />

Customs House, Brisbane<br />

8 September <strong>2013</strong><br />

2 nd International Conference on BioNano Innovation, Beijing,<br />

China<br />

Editorial Contributions<br />

Janice Besch<br />

Erik de Wit<br />

Petrina Gilmore<br />

Peter Gray<br />

Darius Koreis<br />

Design<br />

Darius Koreis<br />

In this issue<br />

1 - Director’s message<br />

2 - AIBN signs Korean cooperation agreement<br />

2 - DSM executives meet at AIBN<br />

2 - AIBN Group Leader a <strong>2013</strong> <strong>Australian</strong><br />

Academy of Science Fellow<br />

2 - Research the best hope <strong>for</strong> spinal injuries<br />

3 - Researchers get their h<strong>and</strong>s dirty in the name<br />

of going green<br />

3 - $375,000 regenerative medicine boost<br />

4 - Accolade <strong>for</strong> student’s design in vaccine<br />

research<br />

4 - Research aims to diagnose without blood tests<br />

5 - AIBN provides leadership in national research<br />

administrator accreditation project<br />

5 - Leading journal appointment shows AIBN’s<br />

strength<br />

5 - Award win <strong>for</strong> protein trouble-shooter<br />

5 - AIBN news briefs<br />

6-7 - PhD Focus - Alex<strong>and</strong>ra Depelsenaire<br />

8 - AIBN Seminar Series - <strong>2013</strong> Semester 1<br />

9 - Donate to AIBN<br />

AIBN <strong>Quarter</strong>ly<br />

Photography<br />

Erik de Wit<br />

Joe Vittorio<br />

Have you got news?<br />

Won an award?<br />

Had a paper published?<br />

Contact us<br />

p.gilmore@uq.edu.au<br />

d.koreis@uq.edu.au<br />

For news as it happens visit<br />

us online www.aibn.uq.edu.au<br />

Or follow us on Twitter<br />

@AIBN_DIRECTOR<br />

And add us to Facebook<br />

QUARTERLY<br />

1


News<br />

AIBN signs Korean cooperation<br />

agreement<br />

An agreement between the AIBN <strong>and</strong> the Center <strong>for</strong> Intelligent<br />

Nano-Bio Materials at the Ewha Womans University, Republic of<br />

Korea, was signed at the <strong>Institute</strong> on 4 March <strong>2013</strong>.<br />

The international agreement allows <strong>for</strong>:<br />

• Both institutions to establish a joint mechanism <strong>for</strong> the exchange<br />

of scholars;<br />

• Sharing <strong>and</strong> exchange of research materials <strong>for</strong> research <strong>and</strong><br />

educational purposes;<br />

• The promotion of joint research activities <strong>and</strong> participation in<br />

conferences, symposia, serial lectures <strong>and</strong> seminars.<br />

Executive Vice President of Ewha Womans University, Professor Jin-<br />

Ho Choy, travelled from Seoul to be the University’s representative<br />

at the signing, <strong>and</strong> also gave a presentation on the University’s<br />

capabilities.<br />

The signing of the agreement followed on from a visit by <strong>Australian</strong><br />

Governor-General <strong>and</strong> UQ Alumnus Ms Quentin Bryce AC CVO to<br />

Ewha Womans University only six days earlier.<br />

DSM executives meet at AIBN<br />

Two influential DSM executives met at the AIBN on 21 March.<br />

Ms Karen King, President of DSM Biologics, has previously visited<br />

the AIBN, however, Mr Stefan Doboczky, a Managing Board<br />

member overseeing the group of which Ms King is President, visited<br />

Brisbane <strong>for</strong> the first time <strong>and</strong> is the highest ranking DSM executive<br />

to have visited Australia.<br />

Mr Doboczky is a member of the five-person Managing Board<br />

of DSM, a blue chip global company active in Life Sciences <strong>and</strong><br />

Materials Sciences with a €9 billion annual turnover.<br />

AIBN is delighted that it has been possible to attract a company<br />

of the calibre of DSM Biologics to be the operator of the biologics<br />

scale-up facility currently being completed alongside the TRI<br />

building.<br />

Biologics are the fastest growing class of human therapeutic<br />

medicines, <strong>and</strong> the Queensl<strong>and</strong> facility is being built as the<br />

‘Biologics Plant of the Future’.<br />

While visiting the AIBN, Mr Doboczky held a meeting with AIBN<br />

Director Professor Peter Gray <strong>and</strong> toured the facilities.<br />

2<br />

QUARTERLY<br />

A large delegation from DSM<br />

visted the AIBN in August 2012<br />

AIBN Group Leader a <strong>2013</strong> <strong>Australian</strong><br />

Academy of Science Fellow<br />

Congratulations to The University of Queensl<strong>and</strong> Deputy Vice-<br />

Chancellor (Research) <strong>and</strong> AIBN Group Leader Professor Max Lu, who<br />

has been selected as <strong>2013</strong> <strong>Australian</strong> Academy of Science Fellow.<br />

Professor Lu is a world leading<br />

scientist in materials science <strong>and</strong><br />

chemical engineering, having made<br />

many significant <strong>and</strong> sustained<br />

contributions including the new<br />

method <strong>for</strong> synthesis of highly<br />

reactive single crystal TiO2.<br />

He has provided new insights into the<br />

surface chemistry <strong>and</strong> modifications<br />

of nanoporous materials, molecular<br />

engineering of membranes <strong>and</strong><br />

efficient photocatalyst <strong>for</strong> clean<br />

energy <strong>and</strong> water.<br />

> Click here <strong>for</strong> full story <<br />

Left to right: Dr Eve Tsai, Dr Fiona Filardo,<br />

Dr Bronwin Dargaville <strong>and</strong> Dr Firas Rasou<br />

Research the best hope <strong>for</strong> spinal<br />

injuries, symposium told<br />

A quadriplegic has urged scientists to keep up their research, saying<br />

even small steps could help make huge improvements to his life.<br />

Spinal Cord Injury Association Brisbane president David Riley spoke<br />

at a one-day symposium at the AIBN.<br />

“I don’t expect to be able to walk around or run around. It is the<br />

little things,” Mr Riley said.<br />

“If I could move one finger, I could drive a vehicle. If I could regain<br />

bowel control, it would give me a much improved quality of life,” he<br />

said.<br />

“I see research <strong>and</strong> a multidisciplinary approach as our best chance.<br />

“There is no cure in the short term. But we are hopeful with research<br />

that there will be improvements in the quality of our lives.”<br />

The symposium attracted speakers from all over the world, including<br />

University of Ottawa neurosurgeon <strong>and</strong> scientist Dr Eve Tsai.<br />

Dr Tsai is collaborating with AIBN’s Dr Firas Rasoul as part of a<br />

State Government’s National <strong>and</strong> International Research Alliance<br />

Program (NIRAP) grant.<br />

She used her trip to Australia to further their research into ways of<br />

stimulating the body to repair itself, provide stem cell therapies to<br />

regenerate <strong>and</strong> repair injured areas.<br />

“Stem cells are a very important area. There is huge potential,” she<br />

said.<br />

“Every dollar of funding could be used <strong>for</strong> work that could<br />

potentially make a huge contribution.<br />

“I go to work <strong>and</strong> see patients with spinal cord injuries. It seems such<br />

a tragedy. Some are so young. Typically, they had one moment of<br />

misjudging something <strong>and</strong> their lives are irrevocably changed <strong>for</strong>ever.”<br />

Dr Rasoul said his research involved designing biomaterials which<br />

could target injured spinal areas, stimulate cell regrowth <strong>and</strong><br />

encourage repairs.<br />

This complemented Dr Tsai’s work, which looked at how a patient<br />

would respond to the medicines or genes to ensure safe <strong>and</strong><br />

effective tissue repair or regrowth.<br />

> Click here <strong>for</strong> full story


News<br />

Left to right:<br />

Professors John<br />

Dorgan, Joe Greene<br />

<strong>and</strong> Peter Halley<br />

Researchers get h<strong>and</strong>s dirty in the name of going green<br />

Professor Peter Halley is working to rid Australia of plastic pollution<br />

through both research <strong>and</strong> elbow-grease.<br />

He is developing degradable plastics <strong>for</strong> agricultural films <strong>and</strong> food<br />

packaging, but Professor Halley is also making sure existing plastics<br />

do not pollute Brisbane’s parks <strong>and</strong> waterways with participation in<br />

Clean Up Australia Day.<br />

Taking part in the day will be two important US collaborators:<br />

Colorado School of Mines biopolymers expert Professor John<br />

Dorgan <strong>and</strong> Cali<strong>for</strong>nia State University biodegradation specialist<br />

Professor Joe Greene.<br />

“I think it is important <strong>for</strong> us to get our h<strong>and</strong>s dirty <strong>and</strong> remember<br />

why we are doing our research,” Professor Halley said.<br />

“It is about creating sustainable products <strong>and</strong> processes which<br />

minimise our effects on the planet.”<br />

With funding from industry <strong>and</strong> government, Professor Halley’s<br />

research group is developing environmentally-responsible plastics.<br />

Professor Dorgan brings experience in bioplastics research <strong>and</strong><br />

development <strong>and</strong> Professor Greene will provide biopolymer<br />

processing <strong>and</strong> biodegradation testing expertise from industry <strong>and</strong><br />

university.<br />

They have also developed green technologies <strong>for</strong> industry, such as<br />

Apple’s iTunes cards <strong>and</strong> specialised laboratory facilities enabling<br />

the study of biodegradation on l<strong>and</strong> <strong>and</strong> in marine parks.<br />

“I have been interested in recycling <strong>and</strong> reducing plastic waste since<br />

my PhD,” Professor Halley said.<br />

“Global population growth coupled to rapid economic development<br />

are increasing water, food <strong>and</strong> energy needs <strong>and</strong> putting enormous<br />

pressure on our environment.”<br />

Researcher’s $375,000 regenerative<br />

medicine boost<br />

Tissue engineer Dr Jess Frith will<br />

determine the role of specific<br />

molecules in cell development in<br />

world-first research, with plans to<br />

use the knowledge to repair bones<br />

<strong>and</strong> cartilage.<br />

Dr Frith will combine cells with<br />

biomaterials to reconstruct body<br />

tissues in the lab, on the path<br />

to one day potentially treating<br />

osteoporosis, osteoarthritis or<br />

intervertebral disc degeneration.<br />

Her work at the <strong>Australian</strong><br />

<strong>Institute</strong> <strong>for</strong> <strong>Bioengineering</strong> <strong>and</strong><br />

Nanotechnology, based at The<br />

University of Queensl<strong>and</strong>, has<br />

received a boost with the awarding<br />

of $375,000 in <strong>Australian</strong> Research<br />

Council Early Career Researcher<br />

Award funding <strong>for</strong> three years.<br />

“I think regenerative medicine has<br />

the potential to trans<strong>for</strong>m medicine<br />

in the future but a major hurdle in<br />

achieving this is our ability to make<br />

cells behave as we want,” she said.<br />

“The cells need to turn into the<br />

correct tissue type. Controlling<br />

this is difficult. We know that stem<br />

cells are very sensitive to the<br />

environment around them.”<br />

This is where Dr Frith’s research<br />

comes in, with plans to investigate<br />

whether molecules called<br />

microRNAs play an important role<br />

in how the response of cells to<br />

their environment determines cell<br />

development.<br />

“I will be using biomaterials to see<br />

if I can influence microRNAs <strong>and</strong><br />

see if I can push stem cells to <strong>for</strong>m<br />

specific tissues.”<br />

She also has a more personal<br />

reason <strong>for</strong> wanting to see advances<br />

in the field.<br />

“My mum has had a spinal fusion<br />

because of intervertebral disc<br />

problems. It was a major procedure<br />

<strong>and</strong> it still hasn’t really fully solved<br />

the problem.<br />

“I would like to think that my<br />

research will one day lead to an<br />

effective alternative, where we can<br />

tissue engineer replacement tissues<br />

that are fully functional.”<br />

QUARTERLY<br />

3


News<br />

Accolade <strong>for</strong> student’s design in vaccine<br />

research<br />

PhD student Stefano Meliga is using mathematical modelling to help develop<br />

a delivery system which is expected to one day vaccinate against a host of<br />

diseases without needle <strong>and</strong> syringe.<br />

The modelling simulates the application to skin of microscopic needles on a<br />

silicon wafer which can be coated with vaccines against key diseases including<br />

influenza, human papillomavirus, herpes simplex, West Nile <strong>and</strong> Chikungunya<br />

viruses.<br />

Design of the wafer, called the Nanopatch, has to be honed <strong>for</strong> use on human<br />

skin, ahead of clinical trials <strong>and</strong> possible roll-out around the world as a newgeneration<br />

vaccine delivery system.<br />

The work has been published this month in the prestigious Journal of Controlled<br />

Release, with Mr Meliga listed as first author.<br />

It adds to Engineers Australia’s National Committee on Applied Mechanics<br />

recognition of the work, with the Postgraduate Student Best Paper Award at the<br />

Australasian Congress of Applied Mechanics at the University of Adelaide.<br />

The $500 prize money will be used to travel to Singapore, where Mr Meliga<br />

plans to build collaborations with Dr Keng-Hwee Chiam at the <strong>Institute</strong> of high<br />

Per<strong>for</strong>mance Computing <strong>and</strong> Professor Victor Shim at the National University of<br />

Singapore – <strong>and</strong> secure validation of his research.<br />

Mr Meliga’s work also involves processing 3D fluorescence-microscopy images to<br />

investigate the transport of vaccine, delivered with the Nanopatch, in the skin.<br />

“I am keen to gain important insights into the penetration of the<br />

microprojections <strong>and</strong> the diffusion of the vaccine across the skin layers,” Mr<br />

Meliga said.<br />

“It is exciting to be involved in this work. The Nanopatch has the potential to<br />

save lives.<br />

“The mathematical skills I am using are fundamentally important <strong>for</strong> the<br />

development of new biomedical applications such as the Nanopatch.<br />

“Development of next-generation devices can’t be solely driven by engineering<br />

intuition. Mathematical modelling such as simulations can effectively drive<br />

experimental testing.<br />

“The satisfaction of finding out what experiments cannot show keeps me glued<br />

to my chair.”<br />

Research aims to diagnose without<br />

blood tests<br />

Dr Simon Corrie has started research on a way of detecting<br />

diseases without the need <strong>for</strong> blood tests or lab analysis, using<br />

$375,000 in <strong>Australian</strong> Research Council funding.<br />

Dr Corrie received an ARC Discovery Early Career Researcher<br />

Award to help in research that combines materials chemistry with<br />

molecular biology to determine if technology used <strong>for</strong> vaccine<br />

delivery device the Nanopatch can also be tailored <strong>for</strong> disease<br />

detection.<br />

He aims to prove that thous<strong>and</strong>s of microscopic needles on a small<br />

polymer wafer can be used to quickly detect biomarkers which<br />

point to the presence of infectious diseases such as dengue fever<br />

<strong>and</strong> malaria.<br />

The device will be designed to sit on the skin, draw in fluids to react<br />

with antibodies <strong>and</strong> reporter probes <strong>and</strong> turn a particular colour,<br />

similar to a litmus test, if biomarkers are present.<br />

“Diagnostic tests are crucially important in many areas of medicine.<br />

While billions of dollars are spent per year developing drugs <strong>for</strong><br />

treatment, only a fraction is spent on diagnostics,” Dr Corrie said.<br />

“However, early <strong>and</strong> accurate diagnosis of disease has proven time<br />

<strong>and</strong> again to drastically improve outcomes <strong>and</strong> survival.”<br />

The benefit of using the microscopic needles in diagnostics is that<br />

it could alleviate the need <strong>for</strong> hospital labs <strong>and</strong> long waits <strong>for</strong><br />

patients.<br />

“Currently diagnostics <strong>for</strong> infectious diseases are designed to be<br />

per<strong>for</strong>med in hospital labs, over the period of hours or days.<br />

“We expect the device to rapidly detect proteins or antibodies,<br />

without the need <strong>for</strong> highly trained health workers or access to<br />

scientific laboratories.<br />

“If the results could be made available immediately at the bedside,<br />

at a GP clinic or at home, this would greatly benefit patients,<br />

health care workers <strong>and</strong> probably reduce burdens on health care<br />

budgets.”<br />

4<br />

QUARTERLY


AIBN provides leadership<br />

in national research<br />

administrator accreditation<br />

project<br />

AIBN’s Deputy Director Operations, Janice Besch, has<br />

accepted the role of facilitating the development<br />

of a training <strong>and</strong> accreditation module on the<br />

National Research & Innovation System in Australia,<br />

as part of a larger project to set in place the <strong>for</strong>mal<br />

accreditation of <strong>Australian</strong> <strong>and</strong> New Zeal<strong>and</strong><br />

Research Administrators.<br />

The project is broad-reaching, with only one other<br />

professional accreditation system in existence<br />

internationally – the Research Administrators<br />

Certification Council (RACC) in the United States.<br />

The objective is to ensure that all of those people<br />

who decide on a career in support of the research<br />

enterprise are well briefed <strong>and</strong> maintain an up to<br />

date body of knowledge in the field.<br />

The lead agency <strong>for</strong> the project is the Australasian<br />

Research Management Society, <strong>and</strong> the Society has<br />

entered into an agreement to collaborate on this front<br />

with its American sister agency.<br />

The UK <strong>and</strong> Europe have already indicated support<br />

<strong>and</strong> potential involvement as collaborators in the<br />

system, adapted <strong>for</strong> their circumstances.<br />

Ten modules of the Accreditation Scheme are in<br />

development, with five considered fundamental to the<br />

research administrator’s body of knowledge.<br />

The module providing a broad underst<strong>and</strong>ing the<br />

National Research Innovation System in Australia will<br />

cover government policy <strong>and</strong> RISsupport <strong>for</strong> research,<br />

the role of funding agencies <strong>and</strong> other supporters of the<br />

system, <strong>and</strong> the research <strong>and</strong> innovation value chain.<br />

The advisory group brings together high-level<br />

representation from Federal <strong>and</strong> Queensl<strong>and</strong><br />

Government agencies responsible <strong>for</strong> research <strong>and</strong><br />

innovation; the National Health & Medical Research<br />

Council; the <strong>Australian</strong> Research Council; the <strong>Australian</strong><br />

Renewable Energy Agency; Universities <strong>and</strong> training<br />

providers.<br />

News<br />

Chancellor’s Award <strong>for</strong> Team<br />

Excellence<br />

Congratulations to the Protein<br />

Expression Facility team <strong>for</strong> winning<br />

The University of Queensl<strong>and</strong>’s<br />

<strong>2013</strong> Chancellor’s Award <strong>for</strong> Team<br />

Excellence.<br />

The team, comprised of Cindy Chang,<br />

Bradley Ryan, Christopher Munro<br />

<strong>and</strong> Emilyn Tan, were honoured at<br />

a ceremony by UQ Chancellor John<br />

Story <strong>and</strong> Vice-Chancellor Professor<br />

Peter Høj.<br />

The award was <strong>for</strong> the team’s<br />

long-st<strong>and</strong>ing commitment <strong>and</strong><br />

outst<strong>and</strong>ing contributions to advance<br />

the University’s st<strong>and</strong>ing as a worldclass<br />

higher education <strong>and</strong> research<br />

institution.<br />

> Click here <strong>for</strong> full story <<br />

Leading journal role shows<br />

AIBN’s strength<br />

AIBN Group Leader Professor Anton Middelberg<br />

has been appointed Associate Editor of the journal<br />

Vaccine.<br />

Vaccine is the pre-eminent journal <strong>for</strong> those<br />

interested in vaccines <strong>and</strong> vaccination.<br />

“This appointment provides recognition that<br />

AIBN, which is well known <strong>for</strong> its ef<strong>for</strong>ts in<br />

commercialising vaccine technology, has also<br />

achieved international recognition <strong>for</strong> its scholarly<br />

activities in the field of vaccine development,”<br />

Professor Middelberg said.<br />

“As an Editor of the leading Vaccine journal,<br />

responsible <strong>for</strong> manufacturing-related papers, I<br />

have direct dialogue with all new developments<br />

in this field, <strong>and</strong> help get this knowledge out from<br />

labs <strong>and</strong> into the worldwide research community,”<br />

he said.<br />

Professor Middelberg is the only <strong>Australian</strong>-based<br />

Editor of the journal.<br />

Other Associate Editors of the publication include<br />

Dr Robert Chen who is head of Vaccine Safety<br />

at the Atlanta-based Center <strong>for</strong> Disease Control<br />

(CDC), <strong>and</strong> Dr Albert Osterhaus from the Erasmus<br />

Medical Centre in the Netherl<strong>and</strong>s.<br />

Dr Osterhaus is one of the world’s leading<br />

virologists <strong>and</strong> his group was the first to identify<br />

human infection with the avian influenza strain<br />

H5N1.<br />

The appointment adds to Professor Middelberg’s<br />

other journal positions as Editor-in-Chief of<br />

Chemical Engineering Science, an Advisory Editorial<br />

Board Member of Trends in Biotechnology, <strong>and</strong><br />

Associate Editor of Biochemical Engineering Journal.<br />

Award win <strong>for</strong> protein<br />

trouble-shooter<br />

He may have only finished his studies 12 months ago,<br />

but Chris Munro is already making a mark in a field<br />

essential <strong>for</strong> developing new-generation vaccines <strong>and</strong><br />

targeted medicine delivery.<br />

The 23-year-old from Chermside produces protein at<br />

the Protein Expression Facility (PEF), housed at the AIBN.<br />

He has become so adept at overcoming challenges in<br />

the work that he has won an award at the Cambridge<br />

Healthtech <strong>Institute</strong> conference PepTalk at Palm<br />

Springs, Cali<strong>for</strong>nia in late January.<br />

“To attend a conference in Palm Springs <strong>and</strong> present<br />

our work was a fantastic opportunity,” Mr Munro said.<br />

“Being able to meet leading researchers from around<br />

the world, many of whom were interested in the work<br />

our facility does, was amazing.”<br />

Together with PEF colleagues, Mr Munro tailors<br />

protein from cells to suit the specific requirements of<br />

researchers so it can be used in vaccine development,<br />

drug discovery or stem cell research.<br />

The extracted protein is then subjected to different<br />

temperatures <strong>and</strong> nutrients to tailor it <strong>for</strong> the specific<br />

requirements.<br />

Protein is a building block used in many research<br />

fields, so Mr Munro’s work could be linked to future<br />

advances in regenerative medicine, vaccination,<br />

therapeutics <strong>and</strong> medicine delivery.<br />

“Finding solutions to the challenges involved in protein<br />

purification is very rewarding. It could be the first step<br />

in overcoming hurdles in disease research,” he said.<br />

“Overcoming them can enable more efficient,<br />

cheaper means of producing therapeutics.”<br />

PEF has a team of eight highly-skilled professionals<br />

producing protein <strong>for</strong> cutting-edge research, freeing<br />

up those in individual laboratories from a task that is<br />

otherwise too costly <strong>and</strong> labour-intensive.<br />

Home grown video<br />

Ever wondered what synthetic<br />

biology is but couldn’t cut through all<br />

the jargon?<br />

AIBN’s Dr Claudia Vickers, along<br />

with collaborators from the Royal<br />

<strong>Institute</strong> of Australia, created a short<br />

educational video that spells it out in<br />

easy to digest language.<br />

You can find out what synthetic<br />

biology is currently used <strong>for</strong>, <strong>and</strong><br />

why it is so important. Some of the<br />

answers might just surprise you...<br />

> Click here to view the video <<br />

Young Scientists of Australia<br />

experience AIBN<br />

20 high school students from across<br />

Queensl<strong>and</strong> visited AIBN on 23<br />

January <strong>2013</strong> as part of Young<br />

Scientists of Australia’s The Science<br />

Experience.<br />

The students gave up a week of their<br />

holidays to come to The University<br />

of Queensl<strong>and</strong> <strong>and</strong> experience what<br />

the University offers in science <strong>and</strong><br />

engineering.<br />

The students toured the AIBN<br />

facilities <strong>and</strong> were given lab<br />

demonstrations <strong>and</strong> the opportunity<br />

to make ice cream making using<br />

liquid nitrogen.<br />

$50,000 Pepfactants grant<br />

AIBN spin-out company Pepfactants<br />

has been awarded a $50,000<br />

Commercialisation Australia Skills &<br />

Knowledge grant.<br />

QUARTERLY<br />

5


PhD Focus<br />

PhDFocus<br />

Alex<strong>and</strong>ra Depelsenaire<br />

29-year-old Alex<strong>and</strong>ra Depelsenaire is in the final year of<br />

her PhD at the AIBN. The German-born student is working<br />

in Professor Mark Kendall’s lab, <strong>and</strong> discovering the impact<br />

that Nanopatch technology has on enhancing immune<br />

responses to vaccines delivered into the skin.<br />

After starting her research at the AIBN in 2009, the end of<br />

her studies is now in sight, <strong>and</strong> she speaks to us about her<br />

research <strong>and</strong> future direction.<br />

What is the title of your project?<br />

How does the localized <strong>and</strong> controlled cell death – invoked by<br />

Nanopatch application to skin – lead to the impaired immune<br />

responses of vaccines?<br />

In a nutshell, what does that mean?<br />

I investigate cellular damage <strong>and</strong> cell death following microneedle<br />

(Nanopatch) application. My results to date emphasise the<br />

immunological impact of damaged cells following vaccine delivery<br />

into the skin. This research is important because it shows <strong>for</strong> the<br />

first time the effect of cell damage generated by different dermal<br />

vaccine delivery devices, in particular microneedles, in conjunction<br />

with the resulting immune response.<br />

How do you go about your work?<br />

Following application of the Nanopatch to skin, I dissect <strong>and</strong> stain<br />

the tissue <strong>for</strong> live <strong>and</strong> dead cells. This tissue sample is then visualised<br />

under our Multiphoton <strong>and</strong> Laser Scanning Confocal microscope<br />

to capture images of the various cells types. I then quantify<br />

the live-dead ratio <strong>and</strong> examine the proximity between them.<br />

Alternatively, I process the skin tissue to extract proteins <strong>and</strong> analyse<br />

<strong>for</strong> particular proteins that are up-regulated in dead cells in<br />

comparison to untreated cells. In animal studies, mice are vaccinated<br />

by the Nanopatch or by a st<strong>and</strong>ard syringe intradermally <strong>and</strong> I<br />

cross-compare the resulting immune responses <strong>and</strong> levels of cell<br />

death between the different cutaneous vaccine delivery devices to<br />

identify a correlation between cell death <strong>and</strong> immunogenicity.<br />

How important are the results of your work <strong>for</strong> seeing the<br />

Nanopatch come to market?<br />

My work will assist in studying <strong>and</strong> - hopefully - advancing our<br />

knowledge base of the mechanism (or mode of action) of the<br />

Nanopatch, which is crucial <strong>for</strong> the human trials. This is key <strong>for</strong> the<br />

Nanopatch to advance as a clinical medical device product.<br />

At what stage are you in your project now?<br />

I’m in my final year, <strong>and</strong> hopefully submitting my thesis in the second<br />

half of this year.<br />

What problems have you encountered in your research?<br />

Doing a PhD includes studying <strong>and</strong> researching something that has<br />

never been done be<strong>for</strong>e. In particular, my work spans different<br />

disciplines, including Engineering <strong>and</strong> Biology, with a main emphasis<br />

on Cell Biology. Some of the imaging techniques have not previously<br />

been per<strong>for</strong>med, hence quite a lot of optimisation was required<br />

prior to obtaining any valuable data. Also, I used different stains<br />

to differentiate between live <strong>and</strong> dead cells; these stains however<br />

have not been fully investigated in skin tissue <strong>and</strong> this also required<br />

quite some tweaking. However, the hard work has paid off <strong>and</strong> my<br />

PhD project is bearing fruit now.<br />

If you could change one thing from the time you’ve been doing<br />

your PhD, what would it be?<br />

Preferably, I would have worked in this field or my current group<br />

The next step...<br />

Once you complete your PhD, what is your next step?<br />

Upon completion, I would like to stay in academia <strong>for</strong> a while to<br />

continue with my research. However, I am also keen on gaining industry<br />

experience. Covering these two fields would eventually enable me to<br />

become a patent attorney – or patent examiner – like my uncle <strong>and</strong><br />

my parents are. Having experience in academia <strong>and</strong> industry is highly<br />

regarded by potential employers.<br />

UQ offers a commercialisation course, which I would like to undertake<br />

to gain a first insight into the <strong>Australian</strong> commercialisation strategy<br />

<strong>and</strong> approach <strong>for</strong> patenting. A law course is not m<strong>and</strong>atory but would<br />

certainly be beneficial further downstream.<br />

So you’ve got commercialisation in your blood?<br />

Yes, I’d say so. My dad was a patent examiner <strong>and</strong> a patent attorney<br />

6<br />

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PhD Focus<br />

Multiphoton <strong>and</strong> Confocal imaging of murine skin<br />

Nanopatches are applied to mouse ears <strong>and</strong> tissue collected at set<br />

time points after application. The tissue is prepared <strong>for</strong> viability<br />

staining to visualise live (green) <strong>and</strong> dead cells (magenta). This<br />

viability analysis is essential to investigate the impact of live <strong>and</strong><br />

dead cells in immune responses following vaccine delivery. Here, we<br />

show that the cell death is tightly localised around the Nanopatch<br />

projections penetrating the skin, co-localising with the vaccine<br />

diffusing off the projections.<br />

prior to starting my PhD as this would have saved me valuable time<br />

in optimising <strong>and</strong> learning new techniques.<br />

What was your background be<strong>for</strong>e starting at AIBN?<br />

I received my Bachelor of Science from Murdoch University (Perth,<br />

WA) as well as a Diploma in Biology by my German University,<br />

while my Honours included research in Nanotechnology (fabrication<br />

of alumina membranes <strong>for</strong> drug delivery).<br />

How do you feel about being involved in a project like the<br />

Nanopatch?<br />

It is a fantastic experience being part of such a multidisciplinary<br />

team like ours. When I started, all I wanted is to combine<br />

Nanotechnology <strong>and</strong> Biology; I didn’t have an idea how big the<br />

impact would be. Due to the large media coverage following our<br />

publications <strong>and</strong> various prizes that have been awarded because<br />

of the results or the promising ‘needle-free vaccine c<strong>and</strong>idate’, the<br />

Nanopatch is known far beyond UQ <strong>and</strong> Brisbane. When asked, <strong>for</strong><br />

instance, nurses, doctors, dentists <strong>and</strong> even hairdressers have heard<br />

of the Nanopatch <strong>and</strong> express great interest in its development.<br />

This feedback amongst conference or reviewed papers is the best<br />

reward <strong>for</strong> me; these comments make it worth staying back late in<br />

the lab... Now, three <strong>and</strong> a half years down the track, I indeed feel<br />

very <strong>for</strong>tunate working in such a multidisciplinary team alongside<br />

engineers, mathematical modellers, (bio-)chemists, biologists,<br />

vaccinologists, immunologists <strong>and</strong> virologists.<br />

How did you hear about AIBN <strong>and</strong> get started on your PhD?<br />

Bluntly, I just Googled ‘Bio <strong>and</strong> Nanotechnology Australia’. One<br />

of the top websites that came up was the AIBN. I looked through<br />

many groups <strong>and</strong> emailed several of the Group Leaders. Mark<br />

Kendall’s project on the Nanopatch sounded the most appealing to<br />

me. Following a visit to Brisbane <strong>and</strong> the research group, I applied<br />

<strong>for</strong> competitive international living <strong>and</strong> tuition scholarships. Once<br />

my scholarship application was approved, I moved from Perth to<br />

Brisbane.<br />

When you one day retire <strong>and</strong> have a chance to look back at your<br />

life, what would you like to say that you’ve accomplished?<br />

That my research has contributed to save or improve the life of at<br />

least one person; <strong>and</strong> that I was able to teach some useful things<br />

to the ‘students of today who will become the scientists of tomorrow’.<br />

who was director of the chemical engineering department at the European<br />

Patent Office (EPO) <strong>for</strong> approximately a decade prior to working as a<br />

consulting European Patent Attorney <strong>for</strong> Peugeot Citroen. My mum also<br />

worked over 10 years <strong>for</strong> the EPO as a patent examiner (chemistry) while<br />

my uncle worked <strong>for</strong> around 20 years <strong>for</strong> the EPO as patent examiner<br />

(electrical engineer) <strong>and</strong> is now a European Patent Attorney.<br />

In addition, I did some part time work after school <strong>for</strong> the EPO which<br />

involved indexing, scanning <strong>and</strong> recognising the various parts of<br />

international patent files.<br />

Has your work on the Nanopatch given an insight to the road to<br />

commercialisation that could be useful as a Patent Attorney?<br />

Yes. Working on the Nanopatch has given me the opportunity to see how<br />

important intellectual property protection can be. Without this in place,<br />

commercialisation could have been significantly impaired.<br />

QUARTERLY<br />

7


News<br />

Seminar Series<br />

Semester I, <strong>2013</strong><br />

<strong>2013</strong> AIBN Seminar Series Coordinator: Petrina Gilmore<br />

Enquiries: p.gilmore@uq.edu.au<br />

Parnell Building 7 - Room 222; 12:00-1:00pm, Thursdays<br />

MARCH<br />

THuRsdAy 7 MARCH<br />

AIBN GENERAL MEETING<br />

THuRsdAy 14 MARCH<br />

Professor Mark Kendall<br />

Group Leader, AIBN, The<br />

University of Queensl<strong>and</strong>;<br />

Director, Vaxxas<br />

Improving the reach of vaccines<br />

to the developing world with<br />

Nanopatches<br />

THuRsdAy 21 MARCH<br />

Professor John Dorgan<br />

Site Director, Colorado Center<br />

<strong>for</strong> Biorefining <strong>and</strong> Biofuels,<br />

Colorado School of Mines, USA<br />

Supramolecular<br />

EcoBioNanocomposites<br />

incorporating<br />

stereocomplexation<br />

THuRsdAy 28 MARCH<br />

Professor Jeff Gorman<br />

Group Leader, Protein Discovery<br />

Centre, Queensl<strong>and</strong> <strong>Institute</strong> of<br />

Medical Research (QIMR)<br />

Proteomic dissection of the<br />

battle between respiratory<br />

syncytial virus <strong>and</strong> epithelial<br />

cells during infection<br />

APRIL<br />

THuRsdAy 11 APRIL<br />

Professor Peter Halley<br />

Group Leader, AIBN, The<br />

University of Queensl<strong>and</strong><br />

Translational Polymer Research<br />

<strong>for</strong> Sustainable Polymers<br />

THuRsdAy 18 APRIL<br />

Professor Robert Booy<br />

Head of Clinical Research,<br />

National Centre <strong>for</strong><br />

Immunisation Research <strong>and</strong><br />

Surveillance (NCIRS), The<br />

University of Sydney<br />

Vaccine Scares <strong>and</strong> Successes<br />

THuRsdAy 25 APRIL<br />

ANZAC DAy PUBLIC HoLIDAy<br />

MAy<br />

THuRsdAy 2 MAy<br />

AIBN GENERAL MEETING<br />

THuRsdAy 9 MAy<br />

Professor Hiroaki Kitano<br />

Sir Louis Matheson<br />

Distinguished Professor,<br />

<strong>Australian</strong> Regenerative<br />

Medicine <strong>Institute</strong>, Monash<br />

University<br />

Systems biology in the context<br />

of systems <strong>and</strong> precision<br />

engineering<br />

THuRsdAy 16 MAy<br />

Professor Gordon Southam<br />

Vale-UQ Geomicrobiology<br />

Laboratory, The University of<br />

Queensl<strong>and</strong><br />

Biological <strong>and</strong> geological<br />

sciences<br />

THuRsdAy 23 MAy<br />

Dr Chris Elvin<br />

Senior Principal Research<br />

Scientist, CSIRo<br />

Molecular Biomimicry: Nature’s<br />

4 billion years of R&D<br />

THuRsdAy 30 MAy<br />

Emeritus Professor Jack<br />

Pettigrew<br />

Queensl<strong>and</strong> Brain <strong>Institute</strong>, The<br />

University of Queensl<strong>and</strong><br />

The Mystery of Bradshaw Rock<br />

Art<br />

JuNE<br />

THuRsdAy 6 JuNE<br />

AIBN GENERAL MEETING<br />

THuRsdAy 20 JuNE<br />

Professor Magnus Nydén<br />

Director, The Ian Wark Research<br />

<strong>Institute</strong>, University of South<br />

Australia<br />

New methods <strong>for</strong> predicting<br />

diffusion in porous materials<br />

<strong>and</strong> new technologies <strong>for</strong><br />

preventing biological growth at<br />

solid liquid interfaces<br />

THuRsdAy 27 JuNE<br />

SEMESTER FINISHED<br />

8<br />

QUARTERLY


Invitation<br />

Did you know... In 2011 AIBN researchers<br />

published 275 peer-reviewed papers?<br />

FURTHER OUR RESEARCH<br />

Help support the <strong>Australian</strong><br />

<strong>Institute</strong> <strong>for</strong> <strong>Bioengineering</strong> <strong>and</strong><br />

Nanotechnology’s vital research.<br />

To donate, please visit:<br />

www.uq.edu.au/giving/aibn<br />

Donate in four key areas<br />

☐ AIBN Scholarships<br />

An AIBN scholarship donation will help nurture the next generation of research<br />

leaders to work towards improved human health, cleaner energies, better<br />

manufacturing practices <strong>and</strong> a sustainable environment.<br />

☐ Neutropaenia Research<br />

AIBN is working with the <strong>Australian</strong> Red Cross <strong>and</strong> Peter MacCallum Cancer<br />

Centre to address Neutropaenia infection in cancer patients undergoing<br />

chemotherapy. With around 200,000 people worldwide hospitalised every<br />

year, one in 14 will consequently die, making it the most common cause of<br />

treatment-related deaths in cancer patients.<br />

☐ AIBN Auditorium<br />

Your gift will allow AIBN researchers access to a world of ideas; facilitating<br />

multi-disciplinary research projects with a truly global outlook <strong>and</strong> the best<br />

chance at success.<br />

☐ AIBN General<br />

AIBN applies a multidisciplinary approach to underst<strong>and</strong>ing <strong>and</strong> exploiting<br />

nanostructures, the genetic basis of cell activity, <strong>and</strong> opportunities at the<br />

interface between bioengineering <strong>and</strong> nanotechnology.<br />

AIBN is building a nationally <strong>and</strong> internationally acknowledged <strong>Institute</strong> in sustained research excellence, with<br />

collaborative links to leading global research groups <strong>and</strong> corporations. New materials, devices <strong>and</strong> processes<br />

based on bioengineering <strong>and</strong> nanotechnology research will address health, energy <strong>and</strong> environmental issues.<br />

QUARTERLY<br />

9

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