Diapositive 1 - WorldPharma 2010
Diapositive 1 - WorldPharma 2010
Diapositive 1 - WorldPharma 2010
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Neonatal outcome: withdrawal syndrome<br />
• Neonatal withdrawal symptoms were reported in two neonates<br />
exposed during the whole pregnancy<br />
◦ A premature female (2,110 g) delivered at 36 weeks from a tramadoladdicted<br />
mother (daily dose of tramadol ≥300mg) experienced :<br />
transient neonatal hypoglycemia at H2<br />
an episode of seizure at H48 and myoclonic movements during 48h (normal<br />
EEG)<br />
◦ A full-term male (3,490g) delivered at 39 weeks from a mother treated<br />
for headache with a maternally reported daily dose of 50mg, experienced<br />
irritability and hyperexitability during his first days of life.<br />
• First description in 1997 (Meyer et al.). Since then at least 2<br />
others published reports involving premature newborns in 2<br />
cases and with a mean maternal daily dose of >350mg.
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