PD Dr. med. Holger Hänßle

PD Dr. med. Holger Hänßle
Klinische Tätigkeit:
Allgemeine Ambulanz
Ambulante Operationen
Pigmentmalsprechstunde
Dermatologische Onkologie und Tumornachsorge-Sprechstunde
Sonographie der Haut und der regionalen Lymphknoten
Phlebologie
Lasersprechstunde
Forschungsschwerpunkte:
Melanomfrüherkennung und (digitale) Dermatoskopie
(Immun-)Therapie des malignen Melanoms
Ultraschalldiagnostik
Genodermatosen (Verhornungsstörungen)
Forschungsförderungen: Niedersächsische Krebsgesellschaft, Bundesministerium für
Wirtschaft und Technologie (ZIM-Projekt), Industrie
Ausgewählte Publikationen:
Melanomfrüherkennung und (digitale) Dermatoskopie
Haenssle H.A., Richter A., Buhl T., Haas E., Holzkamp R., Emmert S., Schön M.P.: Pigmented basal
cell carcinomas 15 years after orbital radiation therapy for Graves ophthalmopathy. Archives of
Dermatology, 2011; 147(4):511-2.
Buhl T., Haenssle H.A.: Symmetrically enlarging pigmented lesion in an adolescent. Hautarzt, 2011;
62(8):625-6.
Buhl T., Hansen-Hagge C., Korpas B., Kaune K.M., Haas E., Rosenberger A., Schön M.P., Emmert
S., Haenssle H.A.: Integrating static and dynamic features of melanoma: The DynaMel algorithm.
Journal of the American Academy of Dermatology, 2011 Jun 7. [Epub ahead of print]
Haenssle H.A., Korpas B., Hansen-Hagge C., Buhl T., Kaune K.M., Johnsen S., Rosenberger A.,
Schön M.P., Emmert S.: Selection of patients for long-term surveillance with digital dermoscopy by
assessment of melanoma risk factors. Archives of Dermatology, 2010; 146(3):257-64.
Haenssle H.A., Korpas B., Hansen-Hagge C., Buhl T., Kaune K.M., Rosenberger A., Krueger U.,
Schön M.P., Emmert S.: Seven-point checklist for dermatoscopy: performance during 10 years of
prospective surveillance of patients at increased melanoma risk. Journal of the American Academy
of Dermatology, 2010; 62(5):785-93.
Haenssle H.A., Kaune K.M., Buhl T., Thoms K.M., Padeken M., Emmert S., Schön M.P.: Melanoma
arising in segmental nevus spilus: detection by sequential digital dermatoscopy. Journal of the
American Academy of Dermatology, 2009; 61(2):337-41.
Haenssle H.A., Kaune K.M., Buhl T., Thoms KM., Padeken M., Mitteldorf C., Emmert S.: Large
speckled lentiginous nevus superimposed with Spitz nevi: Sequential digital dermoscopy may lead to
unnecessary excisions triggered by dynamic changes. Clinical and Experimental Dermatology,
2009; 34(2):212-5.
Haenssle H.A.: Strategien zur klinischen Früherkennung des malignen Melanoms -Gegenwart und
Zukunft. TumorDiagnostik und Therapie, 2009; Ausg. 6, Jahrg. 30: 302-306.
Haenssle H.A.: Melanomfrüherkennung durch sequentielle digitale Dermatoskopie,
Dermatologie, 2009; 35:75–78.
Aktuelle
Haenssle H.A.: Blickdiagnostik: Pigmentmale, Via Medici, Heft 03/2007:62-64

Haenssle H.A., Krueger U., Vente C., Thoms KM., Bertsch HP., Zutt M., Rosenberger A., Neumann
C., Emmert S.: Results from an observational trial: digital epiluminescence microscopy follow-up of
atypical nevi increases the sensitivity and the chance of success of conventional dermoscopy in
detecting melanoma. Journal of Investigative Dermatology, 2006; 126(5):980-5.
Haenssle H.A., Vente C., Bertsch H.P., Rupprecht R., Abuzahra F., Junghans V., Ellinghaus B.,
Emmert S., Hallermann C., Neumann Ch.: Results of a surveillance programme for patients at high
risk for malignant melanoma using digital and conventional dermoscopy. European Journal for
Cancer Prevention, 2004; 13(2):133-8.
(Immun-)Therapie des malignen Melanoms
Haenssle H.A., Riedl P., Buhl T., Schardt A., Rosenberger A., Schön M.P., Schirmbeck R.:
Intracellular delivery of MHC class I-binding epitopes: Dendritic cells loaded and matured with cationic
peptide/poly(I:C) complexes efficiently activate T cells. Experimental Dermatology, 2010; 19(1):19-
28.
Knudsen S., Schardt A., Buhl T., Boeckmann L., Schön M.P., Neumann C., Haenssle H.A.: Enhanced
T-cell activation by immature dendritic cells loaded with HSP70-expressing heat-killed melanoma
cells. Experimental Dermatology, 2010; 19(2):108-16.
Haenssle H.A., Buhl T., Knudsen S., Krueger U., Reich K., Neumann C.: CD40 ligation during
dendritic cell maturation reduces cell death and prevents interleukin-10-induced regression to
macrophagelike monocytes. Experimental Dermatology, 2008; 17(3):177-87.
Kretschmer L., Thoms K.M., Peeters S., Haenssle H.A., Bertsch H.P., Emmert S.: Postoperative
morbidity of lymph node excision for cutaneous melanoma-sentinel lymphonodectomy versus
complete regional lymphnode dissection. Melanoma Research, 2008; 18(1):16-21.
Haenssle H.A.: Vaccination therapy with tumor-dendritic cell hybrids: a promising therapeutic
approach? Current Opinion in Investigational Drugs, 2005; 6(12): 1240-5. Review.
Kretschmer L., Beckmann I., Thoms K.M., Haenssle H.A., Bertsch H.P., Neumann Ch.: Sentinel
lymphonodectomy does not increase the risk of loco-regional cutaneous metastases of malignant
melanomas. European Journal of Cancer, 2005; 41(4):531-8.
Haenssle H.A., Emmert S., Krause S.W., Zutt M., Kretschmer L., Schmidberger H., Andreesen R.,
Soruri A.: Hybrid cell vaccination in metastatic melanoma: Results of a phase I/II study. Journal of
Immunotherapy, 2004; 27(2):147-55.
Emmert S., Zutt M., Haenssle H.A., Neumann C., Kretschmer L.: Inefficacy of vindesine monotherapy
in advanced stage IV malignant melanoma patients previously treated with other chemotherapeutic
agents. Melanoma Research, 2003; 13(3):299-302.
Genodermatosen (Verhornungsstörungen)
Haenssle H.A., Finkenrath A., Hausser I., Oji V., Traupe H., Hennies HC., Neumann C., Emmert S.:
Effective treatment of severe thermodysregulation by oral retinoids in a patient with recessive
congenital lamellar ichthyosis. Clinical and Experimental Dermatology, 2008; 33(5):578-81.
Emmert S., Küster W., Hennies HC., Zutt M., Haenssle H.A., Kretschmer L., and Neumann C.: 47
patients in 14 families with the rare genodermatosis keratosis punctata palmoplantaris Buschke-
Fischer-Brauer. European Journal of Dermatology, 2003; 13:16-20.
Emmert S., Küster W., Zutt M., Hänssle H.A., Hallermann C., Kretschmer L., and Neumann C.: A new
family with the rare genodermatosis keratosis punctata palmo-plantaris Buschke-Fischer-Brauer.
Journal of the American Academy of Dermatology, 2003; 49:1166-1169.

Holger Haenssle, MD
Clinical spectrum:
General Dermatology (outpatient clinic)
Outpatient Surgery
Pigmented Lesion Clinic (dermatoscopy)
Dermatooncology Clinic and Tumor Follow-up Clinic
Ultrasound examination of skin/subcutaneous tissue
Phlebology
Laser Surgery Clinic
Scientific profile:
Early detection of melanoma and (digital) Dermatoscopy
(Immuno-)Therapy of metastasized melanoma
Diagnostic use of Ultrasound
Genodermatoses
Funding: Niedersächsische Krebsgesellschaft, Bundesministerium für
Wirtschaft und Technologie (ZIM-Project), Industry
Selected Publications:
Early detection of melanoma and (digital) Dermatoscopy
Haenssle H.A., Richter A., Buhl T., Haas E., Holzkamp R., Emmert S., Schön M.P.: Pigmented basal
cell carcinomas 15 years after orbital radiation therapy for Graves ophthalmopathy. Archives of
Dermatology, 2011; 147(4):511-2.
Buhl T., Haenssle H.A.: Symmetrically enlarging pigmented lesion in an adolescent. Hautarzt, 2011;
62(8):625-6.
Buhl T., Hansen-Hagge C., Korpas B., Kaune K.M., Haas E., Rosenberger A., Schön M.P., Emmert
S., Haenssle H.A.: Integrating static and dynamic features of melanoma: The DynaMel algorithm.
Journal of the American Academy of Dermatology, 2011 Jun 7. [Epub ahead of print]
Haenssle H.A., Korpas B., Hansen-Hagge C., Buhl T., Kaune K.M., Johnsen S., Rosenberger A.,
Schön M.P., Emmert S.: Selection of patients for long-term surveillance with digital dermoscopy by
assessment of melanoma risk factors. Archives of Dermatology, 2010; 146(3):257-64.
Haenssle H.A., Korpas B., Hansen-Hagge C., Buhl T., Kaune K.M., Rosenberger A., Krueger U.,
Schön M.P., Emmert S.: Seven-point checklist for dermatoscopy: performance during 10 years of
prospective surveillance of patients at increased melanoma risk. Journal of the American Academy
of Dermatology, 2010; 62(5):785-93.
Haenssle H.A., Kaune K.M., Buhl T., Thoms K.M., Padeken M., Emmert S., Schön M.P.: Melanoma
arising in segmental nevus spilus: detection by sequential digital dermatoscopy. Journal of the
American Academy of Dermatology, 2009; 61(2):337-41.
Haenssle H.A., Kaune K.M., Buhl T., Thoms KM., Padeken M., Mitteldorf C., Emmert S.: Large
speckled lentiginous nevus superimposed with Spitz nevi: Sequential digital dermoscopy may lead to
unnecessary excisions triggered by dynamic changes. Clinical and Experimental Dermatology,
2009; 34(2):212-5.
Haenssle H.A.: Strategien zur klinischen Früherkennung des malignen Melanoms -Gegenwart und
Zukunft. TumorDiagnostik und Therapie, 2009; Ausg. 6, Jahrg. 30: 302-306.
Haenssle H.A.: Melanomfrüherkennung durch sequentielle digitale Dermatoskopie,
Dermatologie, 2009; 35:75–78.
Aktuelle
Haenssle H.A.: Blickdiagnostik: Pigmentmale, Via Medici, Heft 03/2007:62-64

Haenssle H.A., Krueger U., Vente C., Thoms KM., Bertsch HP., Zutt M., Rosenberger A., Neumann
C., Emmert S.: Results from an observational trial: digital epiluminescence microscopy follow-up of
atypical nevi increases the sensitivity and the chance of success of conventional dermoscopy in
detecting melanoma. Journal of Investigative Dermatology, 2006; 126(5):980-5.
Haenssle H.A., Vente C., Bertsch H.P., Rupprecht R., Abuzahra F., Junghans V., Ellinghaus B.,
Emmert S., Hallermann C., Neumann Ch.: Results of a surveillance programme for patients at high
risk for malignant melanoma using digital and conventional dermoscopy. European Journal for
Cancer Prevention, 2004; 13(2):133-8.
(Immuno-)Therapy of metastasized Melanoma
Haenssle H.A., Riedl P., Buhl T., Schardt A., Rosenberger A., Schön M.P., Schirmbeck R.:
Intracellular delivery of MHC class I-binding epitopes: Dendritic cells loaded and matured with cationic
peptide/poly(I:C) complexes efficiently activate T cells. Experimental Dermatology, 2010; 19(1):19-
28.
Knudsen S., Schardt A., Buhl T., Boeckmann L., Schön M.P., Neumann C., Haenssle H.A.: Enhanced
T-cell activation by immature dendritic cells loaded with HSP70-expressing heat-killed melanoma
cells. Experimental Dermatology, 2010; 19(2):108-16.
Haenssle H.A., Buhl T., Knudsen S., Krueger U., Reich K., Neumann C.: CD40 ligation during
dendritic cell maturation reduces cell death and prevents interleukin-10-induced regression to
macrophagelike monocytes. Experimental Dermatology, 2008; 17(3):177-87.
Kretschmer L., Thoms K.M., Peeters S., Haenssle H.A., Bertsch H.P., Emmert S.: Postoperative
morbidity of lymph node excision for cutaneous melanoma-sentinel lymphonodectomy versus
complete regional lymphnode dissection. Melanoma Research, 2008; 18(1):16-21.
Haenssle H.A.: Vaccination therapy with tumor-dendritic cell hybrids: a promising therapeutic
approach? Current Opinion in Investigational Drugs, 2005; 6(12): 1240-5. Review.
Kretschmer L., Beckmann I., Thoms K.M., Haenssle H.A., Bertsch H.P., Neumann Ch.: Sentinel
lymphonodectomy does not increase the risk of loco-regional cutaneous metastases of malignant
melanomas. European Journal of Cancer, 2005; 41(4):531-8.
Haenssle H.A., Emmert S., Krause S.W., Zutt M., Kretschmer L., Schmidberger H., Andreesen R.,
Soruri A.: Hybrid cell vaccination in metastatic melanoma: Results of a phase I/II study. Journal of
Immunotherapy, 2004; 27(2):147-55.
Emmert S., Zutt M., Haenssle H.A., Neumann C., Kretschmer L.: Inefficacy of vindesine monotherapy
in advanced stage IV malignant melanoma patients previously treated with other chemotherapeutic
agents. Melanoma Research, 2003; 13(3):299-302.
Genodermatoses
Haenssle H.A., Finkenrath A., Hausser I., Oji V., Traupe H., Hennies HC., Neumann C., Emmert S.:
Effective treatment of severe thermodysregulation by oral retinoids in a patient with recessive
congenital lamellar ichthyosis. Clinical and Experimental Dermatology, 2008; 33(5):578-81.
Emmert S., Küster W., Hennies HC., Zutt M., Haenssle H.A., Kretschmer L., and Neumann C.: 47
patients in 14 families with the rare genodermatosis keratosis punctata palmoplantaris Buschke-
Fischer-Brauer. European Journal of Dermatology, 2003; 13:16-20.
Emmert S., Küster W., Zutt M., Hänssle H.A., Hallermann C., Kretschmer L., and Neumann C.: A new
family with the rare genodermatosis keratosis punctata palmo-plantaris Buschke-Fischer-Brauer.
Journal of the American Academy of Dermatology, 2003; 49:1166-1169.