What Bioinformatics - Analyse und Management komplexer Systeme

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The Role of Theory in Biology: Little Impact Thus Far Sydney Brenner Princeton University 2003: The Watson Lecture: Biology in the Era of Complete Genomes ETH Zürich 2006: Pauli-Vorlesung: Theoretical Biology in the Next Decade The close interplay between theory, modeling, and experiment has dominated many other branches of science, particularly physics and astrophysics, but it had little impact on biology until now. I used to refer to the Journal of Theoretical Biology as the cure to insomnia. No longer will I be able to say that. The genome and its vast accumulation of data have the potential to change all of that by opening the doors for scientists with more analytical and theoretical bents.
The Role of Theory in Biology: An Analogy Johannes Kepler used Tycho's detailed astronomical information to develop his theories of astronomy (Kepler Laws). In a certain sense bioinformatics and theoretical biology are currently in a situation that still awaits the discovery of the Kepler Laws.
Page 1 and 2: What Bioinformatics Is All About J
Page 3 and 4: Complex Biological Systems Any func
Page 6 and 7: Molecules of Life (CARBOHYDRATES)
Page 8 and 9: Pathways, Networks, Systems
Page 10 and 11: Technological Development: Microarr
Page 13 and 14: Genome Sizes
Page 15 and 16: Down syndrome, trisomy 21 FLI
Page 18 and 19: It´s not just the genes: epigeneti
Page 20 and 21: Data Explosion
Page 22 and 23: The First Complete Genomes (of free
Page 24 and 25: PDB Content Growth New Structures P
Page 26 and 27: What is Bioinformatics ? Bioinforma
Page 30 and 31: How Bioinformatics Contributes to G
Page 32 and 33: Dot Plot D. W. Mount: Bioinformatic
Page 34 and 35: Local BLAST Alignment
Page 36 and 37: Single Nucleotide Polymorphisms (SN
Page 38 and 39: Genetic Diseases monogenic polygeni
Page 40 and 41: Drug research is the search for a n
Page 42 and 43: Drug Development Virtual Ligand Scr
Page 44 and 45: Structure-based Design: Virtual Scr
Page 46 and 47: Computer Power for Bioinformatics/C
Page 48 and 49: Computer Power for Bioinformatics/C
Page 50 and 51: Protein Folding by Molecular Dynami
Page 56 and 57: Text Mining: Duplication of Scienti
Page 58 and 59: Ethical Issues Genes are the organi
Page 60 and 61: Genetic fingerprinting, DNA typing
Page 62 and 63: What are the Most Important Current
Page 64 and 65: What are the Most Important Current
Page 66 and 67: Outlook A warning: Do not be too fa
Page 68 and 69: www.fli-leibniz.de/jcb/ Coordinator
Page 70: Publications, Talks, Posters, Diplo

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