Best Design of BE Studies (7) - BEBAC ⢠Consultancy Services for ...
Best Design of BE Studies (7) - BEBAC ⢠Consultancy Services for ...
Best Design of BE Studies (7) - BEBAC ⢠Consultancy Services for ...
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7/7 | Statistical <strong>Design</strong> and Analysis IIII<br />
Dose Proportionality<br />
Two-step procedure<br />
Example (FIM, 6 dose levels, C max )<br />
2000<br />
1500<br />
Dose Proportionality (Cmax)<br />
1000<br />
500<br />
Observed<br />
Predicted<br />
0<br />
0 2 4 6 8 10 12<br />
dose (mg)<br />
in<strong>for</strong>ma<br />
life sciences<br />
Bioequivalence and Bioavailability, Pre-conference workshop | Budapest, 11 May 2009 14 • 19
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