2013 Applying Next Generation Sequencing Brochure.pdf

Cover
Inaugural
August 19-20, 2013
Conference-at-a-Glance
Short Courses/Plenary Keynote
Sequencing Strategies for Success
Dynamics of the Microbiome
on Health and Disease
Single-Cell Sequencing
Sequencing Data Analysis
and Interpretation
Sponsor & Exhibit Opportunities
NG X Dynamics of the Microbiome
on Health and Disease
Communities, Composition, and Computation
Advances in next-generation sequencing and computation have elucidated the impact of human genomic variation; however, the
impact of this variation is largely unexplored in the human microbiome. Now clinical and environmental researchers have the
high-resolution tools to explore the emergent science of microbial communities and the ecosystems they inhabit. CHI’s Dynamics
of the Microbiome on Health and Disease conference focuses on understanding the role of the microbiome to offer new insights
into disease processes and discovery of new therapeutic strategies.
Monday, August 19
8:30 am Short Course Registration and Morning Coffee
database. Our results show several new potential bacterial agents that may be associated with
different diseases with unknown etiologies. We are currently in the process of translating these
methods to the clinic where these approaches can immediately impact human health.
Hotel & Travel Information
Registration Information
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Healthtech.com/Sequencing
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Cambridge Healthtech Institute
250 First Avenue, Suite 300
Needham, MA 02494
www.healthtech.com
9:00-12:00 pm Short Courses* (see page 3 for details)
SC1: Mapping Genomes in 3D
SC2: Sample Prep
1:00 Main Conference Registration
Communities and Composition
2:00 Chairperson’s Opening Remarks
Emma Allen-Vercoe, Ph.D., Assistant Professor, Molecular and Cellular Biology, University
of Guelph
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Featured Presentation
2:10 Metagenomic Platforms for Diagnostic, Microbial Composition and
Etiologic Agent Discovery Applications
Joseph Petrosino, Ph.D., Assistant Professor, Molecular Virology and Microbiology; Director,
Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine
Metagenomics strategies for etiologic agent discovery and diagnostic detection have multiple
advantages over past methods: they are highly sensitive; they are able to detect sub-PFU levels of
viruses in clinical samples; there is no requirement for propagation of the suspected agent in the
laboratory; and there is no need for prior knowledge of the agent to be detected. For suspected
bacterial agents we are using 16S rRNA gene and whole-genome shotgun surveys of diverse human
samples to identify potential agents and antibiotic resistance profiles. For suspected viral agents
we are sequencing randomly primed cDNA libraries and querying these data against a custom viral
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2:40 Archaea and Fungi of the Human Gut Microbiome
Christian Hoffmann, Research Scientist, Frederic D. Bushman Laboratory, Microbiology,
Perelman School of Medicine, University of Pennsylvania
We investigate associations of diet with fungal and archaeal populations in the gut
microbiome, as well as interdomain relationships between bacteria, archaea and fungi in a
cohort of 96 individuals. Diet relationships with microbial taxa were investigated regarding
usual and recent dietary intake.
3:10 Microbial Ecosystems Therapeutics: A New Paradigm in Medicine?
Emma Allen-Vercoe, Ph.D., Assistant Professor, Molecular and Cellular Biology, University
of Guelph
It is now clearly recognized that the human gut microbial ecosystem is a critical factor in the
maintenance of host health, and that disturbances in this ecosystem, leading to enduring
imbalance (dysbiosis) are associated with an ever increasing number of disorders (for example,
IBD, IBS, diabetes, asthma, autism). With this in mind, is it possible to harness the microbial
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