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Virulence Factors • PSM (=phenol soluble protein) • PVL • δ toxin • Agr II- less vancomycin susceptible • Agr III- in CA MRSA strains more commonly (Agr operon upregulates secretion of virulence factors and downregulates expression of virulence factors on the bacterial surface)
S.aureus aetiology of CAP: culture + and hospitalised ? Author S.aureus (%) MRSA Kollef et al 2005 25.5% - Large US outcomes database Stralin & Soderquist 2006 7.3% - Single institution Marrie . 2001 2.9% - Review of seven studies Torres et al 2009 Woodhead 2002 0-11.73% 4.9 % - - Country specific across Europe Review of 41 prospective studies
Page 1 and 2: Disclosures Research support: Daiic
Page 3 and 4: Facts about nosocomial pneumonia (N
Page 5 and 6: Facts about staphylococcal NP • T
Page 7 and 8: MRSA prolongs ICU stay in VAP, desp
Page 9: Emergency department radiograph
Page 12 and 13: STAPHYLOCOCCAL PNEUMONIA (SP) • P
Page 16 and 17: Hayward et al. Emerg Inf Dis. 2008;
Page 18 and 19: MRSA Load in the UK Male age standa
Page 20 and 21: Incidence of Nosocomial pneumonia c
Page 22 and 23: USA • S.aureus in 20% of cases of
Page 24 and 25: Vancomycin MIC creep 80 70 60 MIC
Page 26 and 27: Reduced vancomycin efficacy with hi
Page 28 and 29: Risk Factors for Multidrug-Resistan
Page 30 and 31: Mortality Rates Associated With Ina
Page 32 and 33: Mortality Risk with Increasing Dela
Page 34 and 35: Linezolid vs vancomycin for Gram-po
Page 36 and 37: Wunderink RG, et al. Chest. 2008;13
Page 38 and 39: Not such smart therapy • Vanco in
Page 40 and 41: RECENT STUDIES IN HAP/VAP Tigecycli
Page 42: Following his admission to the inte
Page 45 and 46: Characteristics of pneumonia caused
Page 47 and 48: Clinical features of PVL-associated
Page 49 and 50: 350% 300% PVL level reported to con
Page 53 and 54: Which antibiotics on MRSA? Vancomyc
Page 55 and 56: New therapeutic options for Resista
Page 57 and 58: • The real world utilization of t
Page 60: Liang Beibei, et al. International

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